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<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ML26</accession>
    <name>A0A075ML26_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Probable thymidylate kinase</fullName>
            <ecNumber evidence="7">2.7.4.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">dTMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tmk</name>
        <name evidence="9" type="ORF">NTE_00052</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 7">
            <text>dTMP + ATP = dTDP + ADP</text>
            <dbReference type="Rhea" id="RHEA:13517"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58369"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the thymidylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.9" evidence="7"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699197.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ML26"/>
    <dbReference type="STRING" id="1459636.NTE_00052"/>
    <dbReference type="GeneID" id="41596003"/>
    <dbReference type="KEGG" id="nev:NTE_00052"/>
    <dbReference type="eggNOG" id="arCOG01891">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049131_1_1_2"/>
    <dbReference type="OrthoDB" id="43083at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004798">
        <property type="term" value="F:dTMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006233">
        <property type="term" value="P:dTDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006227">
        <property type="term" value="P:dUDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01672">
        <property type="entry name" value="TMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00165">
        <property type="entry name" value="Thymidylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039430">
        <property type="entry name" value="Thymidylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018094">
        <property type="entry name" value="Thymidylate_kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00041">
        <property type="entry name" value="DTMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10344">
        <property type="entry name" value="THYMIDYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10344:SF1">
        <property type="entry name" value="THYMIDYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02223">
        <property type="entry name" value="Thymidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate kinase-like" evidence="8">
        <location>
            <begin position="37"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF82136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="249" mass="27971" checksum="2C12FBA404DA4CC6" modified="2014-10-29" version="1">MRRGRAVAAAAERTLQFYGHGIPYIEDTGIKGRLIVIEGPDASGRSTQIGLITAKLEAAGHAVLNTGLKRSELISEGILEAKRNFAGRKTLSLFYAADFADQLENKIIPALRAGYVVLADRYIYTLLAREAVRGISRRWSHNLFSFAIVPDLVFYLDVEPEELVHRVFQKNAYLDYYESGADMGLANDMFESFMKYQAMIAKEFRRMQKRYNLVIIDGNRSIPEINADLQKRIDAFLESAHAASSKATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ML81</accession>
    <name>A0A075ML81_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein, 4-oxalocrotonate tautomerase</fullName>
            <ecNumber evidence="4">5.3.2.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_00099</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 4-oxalocrotonate tautomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.2.-" evidence="4"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699229.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ML81"/>
    <dbReference type="STRING" id="1459636.NTE_00099"/>
    <dbReference type="GeneID" id="41596043"/>
    <dbReference type="KEGG" id="nev:NTE_00099"/>
    <dbReference type="eggNOG" id="arCOG02240">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148073_5_3_2"/>
    <dbReference type="OrthoDB" id="8161at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.429.10">
        <property type="entry name" value="Macrophage Migration Inhibitory Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004370">
        <property type="entry name" value="4-OT-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014347">
        <property type="entry name" value="Tautomerase/MIF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35530:SF2">
        <property type="entry name" value="BSL4019 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35530">
        <property type="entry name" value="TAUTOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01361">
        <property type="entry name" value="Tautomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55331">
        <property type="entry name" value="Tautomerase/MIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4-oxalocrotonate tautomerase-like" evidence="3">
        <location>
            <begin position="2"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF82181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="58" mass="6560" checksum="318BF48C14A83AC7" modified="2014-10-29" version="1">MPLILVSLYPGRTKEQKDEFAKAVTDAAVSILKTKAEHVIVVYDENPKENWFQAGKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLG4</accession>
    <name>A0A075MLG4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00209</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699307.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLG4"/>
    <dbReference type="STRING" id="1459636.NTE_00209"/>
    <dbReference type="GeneID" id="41596131"/>
    <dbReference type="KEGG" id="nev:NTE_00209"/>
    <dbReference type="HOGENOM" id="CLU_2419873_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="91" mass="10504" checksum="27B3765B04EA0B08" modified="2014-10-29" version="1">MNKVKISSQPVRGDVLQKALDDLDLWGEEFSRVIAKILQANGLVFDANYYYSLDDIEKPLRRFLGRENARQICEVIKIGIQVQYFSSIHDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLM9</accession>
    <name>A0A075MLM9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Short C-terminal domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_00101</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158384869.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLM9"/>
    <dbReference type="STRING" id="1459636.NTE_00101"/>
    <dbReference type="GeneID" id="41596045"/>
    <dbReference type="KEGG" id="nev:NTE_00101"/>
    <dbReference type="HOGENOM" id="CLU_1253624_0_0_2"/>
    <dbReference type="OrthoDB" id="9227at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018649">
        <property type="entry name" value="SHOCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039519">
        <property type="entry name" value="YokE-like_PH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14470">
        <property type="entry name" value="bPH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09851">
        <property type="entry name" value="SHOCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YokE-like PH" evidence="2">
        <location>
            <begin position="31"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="SHOCT" evidence="1">
        <location>
            <begin position="168"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF82183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="198" mass="21846" checksum="8618C865777A1242" modified="2014-10-29" version="1">MFGGEDDKAKFNTVLTDEDDLAEIKKIADRLDEDETVLVVARQSRVKPGGSLTTPNIIFATNKRLIIRDPRSLGLRQSIEDISYDRITSARIDQGMLSSRIILRAPGLSTIAEKKLDGITMGSDSNEGQIEAIPKDKAEKIIEAVNQGIQRAKVPTTTIVNNQASIADELDKLAKLKEQGVLSEAEFVQMKQELLKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLP6</accession>
    <name>A0A075MLP6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00329</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158384950.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLP6"/>
    <dbReference type="GeneID" id="43502554"/>
    <dbReference type="KEGG" id="nev:NTE_00329"/>
    <dbReference type="HOGENOM" id="CLU_3162927_0_0_2"/>
    <dbReference type="OrthoDB" id="9391at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="47" mass="5077" checksum="418D55BC22B9DEE8" modified="2014-10-29" version="1">MTDPVKDAKKAVQDAEAKIKTDVDHAKGKPSSETLNKAKVKVKDALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLX8</accession>
    <name>A0A075MLX8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Arsenite methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.137</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NTE_00056</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>arsenic triglutathione + 2 [thioredoxin]-dithiol + 2 S-adenosyl-L-methionine + H2O = dimethylarsinous acid + 2 [thioredoxin]-disulfide + 3 glutathione + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:69464"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:23808"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:183640"/>
            <dbReference type="EC" id="2.1.1.137"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>arsenic triglutathione + 3 [thioredoxin]-dithiol + 3 S-adenosyl-L-methionine = trimethylarsine + 3 [thioredoxin]-disulfide + 3 glutathione + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:69432"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:27130"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:183640"/>
            <dbReference type="EC" id="2.1.1.137"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>arsenic triglutathione + [thioredoxin]-dithiol + S-adenosyl-L-methionine + 2 H2O = methylarsonous acid + [thioredoxin]-disulfide + 3 glutathione + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69460"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17826"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:183640"/>
            <dbReference type="EC" id="2.1.1.137"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methyltransferase superfamily. Arsenite methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.137" evidence="4"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699201.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLX8"/>
    <dbReference type="STRING" id="1459636.NTE_00056"/>
    <dbReference type="GeneID" id="41596007"/>
    <dbReference type="KEGG" id="nev:NTE_00056"/>
    <dbReference type="eggNOG" id="arCOG01792">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052868_1_1_2"/>
    <dbReference type="OrthoDB" id="57427at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030791">
        <property type="term" value="F:arsenite methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026669">
        <property type="entry name" value="Arsenite_MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008823">
        <property type="entry name" value="PRK11873.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43675">
        <property type="entry name" value="ARSENITE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43675:SF8">
        <property type="entry name" value="ARSENITE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Methyltransferase" evidence="9">
        <location>
            <begin position="76"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00034487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIF82140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="251" mass="26594" checksum="B3DE06AD1035FB64" modified="2014-10-29" version="1">MNNNGNIKEKVREKYGRVALLQDSCCGPGECGCGTSLSPMEAAGATGYSKEDLSSVPEAAILGAGCGAPLNFADLKEGETVVDLGSGAGIDVFLSAKRVGAGGRAIGIDMTDEMLAKARKNASEHGGYENVEFRKGDIEERIPLEDASADAVISNCVINLTLDKVKTFSEIHRVLKDGGRMVISDIVTDSEAEAVDPEEWCSCIDGALTKENYVAAIKKAGFGNATVLEERPYIEKVDGRRLSSIVVRAMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MM28</accession>
    <name>A0A075MM28_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_00098</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158384867.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MM28"/>
    <dbReference type="STRING" id="1459636.NTE_00098"/>
    <dbReference type="GeneID" id="41596042"/>
    <dbReference type="KEGG" id="nev:NTE_00098"/>
    <dbReference type="eggNOG" id="arCOG04060">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2177956_0_0_2"/>
    <dbReference type="OrthoDB" id="371772at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="33"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF82180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="118" mass="12602" checksum="33939087F524F62F" modified="2014-10-29" version="1">MSSSDNGSSIANASELTWIAGAVVLSDNPPQQLKFWRKKFGVKQADLAKKMAITPSVLSDYEKGRRPSPGANFIKRYLQALYELAQSGGGPGPHVEQETTATPEEPMTAGAAVTINQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MM36</accession>
    <name>A0A075MM36_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA topoisomerase 1</fullName>
            <ecNumber evidence="9">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">DNA topoisomerase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">topA</name>
        <name evidence="12" type="ORF">NTE_00103</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="9"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699231.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MM36"/>
    <dbReference type="STRING" id="1459636.NTE_00103"/>
    <dbReference type="GeneID" id="41596046"/>
    <dbReference type="KEGG" id="nev:NTE_00103"/>
    <dbReference type="eggNOG" id="arCOG01527">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002929_5_2_2"/>
    <dbReference type="OrthoDB" id="30963at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03362">
        <property type="entry name" value="TOPRIM_TopoIA_TopoIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="entry name" value="Topoisomerase I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="entry name" value="Topoisomerase I, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="entry name" value="Topoisomerase I, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00952">
        <property type="entry name" value="Topoisom_1_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023406">
        <property type="entry name" value="Topo_IA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005739">
        <property type="entry name" value="TopoI_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028612">
        <property type="entry name" value="Topoisom_1_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034144">
        <property type="entry name" value="TOPRIM_TopoIII"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01057">
        <property type="entry name" value="topA_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390:SF26">
        <property type="entry name" value="DNA TOPOISOMERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390">
        <property type="entry name" value="PROKARYOTIC DNA TOPOISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="Prokaryotic type I DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00396">
        <property type="entry name" value="TOPO_IA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52039">
        <property type="entry name" value="TOPO_IA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 9 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0799">Topoisomerase</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Toprim" evidence="10">
        <location>
            <begin position="4"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Topo IA-type catalytic" evidence="11">
        <location>
            <begin position="165"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with DNA" evidence="9">
        <location>
            <begin position="205"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="9">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="9">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="9">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="9">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="9">
        <location>
            <position position="328"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="9">
        <location>
            <position position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIF82185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="704" mass="76945" checksum="C52221C7B8AEAE02" modified="2014-10-29" version="1">MSSYTLVVCEKPDAARRIASALGSASESRSTAGGVSVFDVMYAGRNYKVCSASGHLYVLADKTKNRSVYPVLDLEWAPIDSGNGNKKNAKGAARAARFINTISFLARGADSFIHACDYDQEGEVIGHSILEYACGGKYDKSLRAKFSTLTDDEVKEAFATLAKPSSRLAQAGRSRHMLDFIYGVNLSRALAQSFKAGSSGYRNLSIGRVQGPTLAFVADRELEIRLHVPDPYWVLTADFDKDGQAVHARYEKPRIEKLAQARAVLDACTGRDGTVSKVSAKKAVLRPPTPFNTGDLQREAYRLFRLSPGYTLAIAEKLYLRALVSYPRTSSQKLPPSINYAKVLSGLAGVSLYSQPASTLLSRGRLVPNEGLMADPAHPAIYPTGVAPRLSGLEFKVYDLIAKRFLATFGDPAVTERTDVSINVNNHVFLAEGRAVLYDGWMALYRPYVNLEQSTLPQLHEGDVLANRQVVMEEKFTQPPWRYSQASLLAKMEEEKIGTKATRADTIATLFKRNYIATKKASGIEATDLGFAVVESMREHAPTIVSTELTRSMEEQLEGIEQGMKEPVDVIEYAVERLVESLATFREQGATIGRQIGSAAATQSNAVIVIGGCPVCKNGQLRIIRSRTTEKRFVGCSNYASGGCRASAPLPQKGGIRVSKTCQCGWPIISVAFGRGGKRWNTCVNMQCPYKRDRASLARRSAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MM97</accession>
    <name>A0A075MM97_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00301</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MM97"/>
    <dbReference type="STRING" id="1459636.NTE_00301"/>
    <dbReference type="KEGG" id="nev:NTE_00301"/>
    <dbReference type="HOGENOM" id="CLU_533833_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="510" mass="54959" checksum="67CC58EA48F7A9C9" modified="2014-10-29" version="1">MCMYHTVSIMYDRHKLPFMATTSTLKNPSGNLAPIKAVFYKELQKQAQSTVQGLLKTGTWYPIDASGLGNFPWYWNNTGIFNTNTWNWFNNIFSYNKDTGYLETHDSSLLGGLFNTYLQISYALSSKDNAAYNDAANKAAAIINTVVGDYTTMFGAIPPEKSGTAAAKMDYVTQQILSWAPTPITLAQLRTSLNPLSLLGNAPFGSSKIITDFMSYLNQTAPVQSIQNAIATQNAEIQRCAANLQPAPSTAQPGWMNTQDSNGNASIQPYLNIAQSTANIQNALCPTSGGASFSVGMTVNKIDQNTVKVSASGGAAGEGWIDLFTFGGGASASYDMFSFDQTLKTCNINLTFKGVTTVTPMLSGSAYQASSGTGWWNPDVIKQAVQNQSKGDVSGLKFTTPPVYDYKTNGTFGVLGNIIISQLPTFSLTYTTSNTKIFQQTFQEQSSWNIGFLGIPIAGGKQSYYSSQYSADTTKGTVTVTMSPPANDTPVSLLDQLAYVIGAEVIWPGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMQ6</accession>
    <name>A0A075MMQ6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Molecular chaperone (Small heat shock protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_00353</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699410.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMQ6"/>
    <dbReference type="STRING" id="1459636.NTE_00353"/>
    <dbReference type="GeneID" id="41596244"/>
    <dbReference type="KEGG" id="nev:NTE_00353"/>
    <dbReference type="eggNOG" id="arCOG01833">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117605_1_0_2"/>
    <dbReference type="OrthoDB" id="26084at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041800">
        <property type="entry name" value="Hsp20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="79"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF82435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="178" mass="20390" checksum="779B81002257263C" modified="2014-10-29" version="1">MWRDRDFSFGRRLFEDIDREFAEAEEMLNRMFRTVRDLRPEEIATNFPYYYGYQVTVGPDGRPHVREFGNIKPSTKGLVAPSETREPLVDTALDEKENVLTITAEMPGVTKQDIKVSVSEEQVSIHAEKDNKKYHTEIPVNMALDDKSAKATYANGILELKIKLKEAPKPKATDVKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMR9</accession>
    <name>A0A075MMR9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase propeptide domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_00368</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699423.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMR9"/>
    <dbReference type="GeneID" id="41596258"/>
    <dbReference type="KEGG" id="nev:NTE_00368"/>
    <dbReference type="HOGENOM" id="CLU_1222565_0_0_2"/>
    <dbReference type="OrthoDB" id="12249at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025711">
        <property type="entry name" value="PepSY"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03413">
        <property type="entry name" value="PepSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PepSY" evidence="2">
        <location>
            <begin position="111"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF82450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="194" mass="20289" checksum="5C27E5C5D9994B80" modified="2014-10-29" version="1">MSSPTGNKKLFIPVLLVAVVAAVGSSAILLLLPSVASAQTMTDQQGDNSTITAPEENNTTTDQENNSTITAPEENNTAQASEQGPEMIVGTIRVNENATADEFPEENLNVTVANATNIAKTQAFNGTVVDAHLAVIQGYLVYNVVLADVPNSTTYTVIVDAGDGNVLFTSPPIPVEKSVIQNAIEESSGEEEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMZ0</accession>
    <name>A0A075MMZ0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00753</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMZ0"/>
    <dbReference type="KEGG" id="nev:NTE_00753"/>
    <dbReference type="HOGENOM" id="CLU_1727302_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="147" mass="17579" checksum="252CE9BC1993B39B" modified="2014-10-29" version="1">MKMIQLWTNLDETEFAIKLASDAIGFRASTSDTADYVKLIDEIHEMDDQQIDWPFMLGKWIASWKDGFRHSALQYGHRTQKSQKDTAHDTLAYFPASNIKQKRKRGKRRRKSRRRKLDVRCRFCNLMFYNDVERATHEKEWHANKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMZ4</accession>
    <name>A0A075MMZ4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative hydrolase or acyltransferase of alpha/beta superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_00763</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699734.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMZ4"/>
    <dbReference type="STRING" id="1459636.NTE_00763"/>
    <dbReference type="GeneID" id="41596614"/>
    <dbReference type="KEGG" id="nev:NTE_00763"/>
    <dbReference type="eggNOG" id="arCOG01648">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG07416">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_13_9_2"/>
    <dbReference type="OrthoDB" id="7466at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46438">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="65"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF82841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="314" mass="34505" checksum="2EDDA4132DB01350" modified="2014-10-29" version="1">MKKESYASIGHHVKVRYLEASIEKEEAASPISFPYDWAKNSKNANSTPPSSSAGRPKSGKQPPRHVLFIHGLGSSADRWLDIPDAMSLLGFHAVAIDLPGFGGSDRPLDTDYYTVENFAQAIAEFMHKIGIDDGKTSIVGHSLGGYIAAQLAIGHRDLVDKLVLIDSSGMLQGPTPLLREYLDAAMSPSRQSVRKVFEQLVADPARIPDVLVDGFIYRIQQPNAQLAFKSAYNNSTSTQIGIKRLKLIDQKNVPTLIVWGSEDRLIPPKYCQIFKEGTRNSLAVIVKDAGHAPFAEKPAVVCELLHDFLKPYNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MN11</accession>
    <name>A0A075MN11_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Small-conductance mechanosensitive channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NTE_00125</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158384880.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MN11"/>
    <dbReference type="STRING" id="1459636.NTE_00125"/>
    <dbReference type="GeneID" id="41596065"/>
    <dbReference type="KEGG" id="nev:NTE_00125"/>
    <dbReference type="eggNOG" id="arCOG01568">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_992540_0_0_2"/>
    <dbReference type="OrthoDB" id="11475at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045275">
        <property type="entry name" value="MscS_archaea/bacteria_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_beta-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30221">
        <property type="entry name" value="SMALL-CONDUCTANCE MECHANOSENSITIVE CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30221:SF1">
        <property type="entry name" value="SMALL-CONDUCTANCE MECHANOSENSITIVE CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Mechanosensitive ion channel MscS" evidence="6">
        <location>
            <begin position="141"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF82207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="284" mass="30804" checksum="90BFD00F1E297F8B" modified="2014-10-29" version="1">MAVASQDAVAARQNGSASVVRQITRLVLITLLITMATWVGLYLFEQFLAPDLGIQHIHMQLTGSAITAAVSFVLIYAVRRIVHKNVARINPHLSTILSFFVIITISLIAAVVLMHQWGIDPQVILVSGGLTAIIAGIALSDIVGNILAGGLVLTAFPAKVSDHVFMIGDNIHGVIDDVHLMYTKIITDDNTEYYIPNNAILQGSVRIIKERPLNHLLPIKEGEHVQIIASTEKYAGTVSKITSKFFFLASDGDANKEIVLANANLISGQYVIIKDRPGKQPVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MN12</accession>
    <name>A0A075MN12_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00567</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385023.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MN12"/>
    <dbReference type="GeneID" id="41596432"/>
    <dbReference type="KEGG" id="nev:NTE_00567"/>
    <dbReference type="HOGENOM" id="CLU_2177769_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="109" mass="11102" checksum="6E304A74BD49BA57" modified="2014-10-29" version="1">MAATVAMAAMEEIVMVPATAETEVTAAMVETAATASSVPDMAAAATEVTEVTVEMEEIVTVPVTEVTVGMAATEVTAAIADMMKTTMMTTNTTSTPNTTSTTSTNITDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MN27</accession>
    <name>A0A075MN27_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Type II methyltransferase</fullName>
            <ecNumber evidence="8">2.1.1.113</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">N-4 cytosine-specific methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NTE_00834</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = an N(4)-methyl-2'-deoxycytidine in DNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16857"/>
            <dbReference type="Rhea" id="RHEA-COMP:11369"/>
            <dbReference type="Rhea" id="RHEA-COMP:13674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:85452"/>
            <dbReference type="ChEBI" id="CHEBI:137933"/>
            <dbReference type="EC" id="2.1.1.113"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.113" evidence="8"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699785.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MN27"/>
    <dbReference type="STRING" id="1459636.NTE_00834"/>
    <dbReference type="REBASE" id="90019">
        <property type="entry name" value="M.NevSR1ORF834P"/>
    </dbReference>
    <dbReference type="GeneID" id="41596679"/>
    <dbReference type="KEGG" id="nev:NTE_00834"/>
    <dbReference type="eggNOG" id="arCOG00115">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024927_2_3_2"/>
    <dbReference type="OrthoDB" id="38200at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015667">
        <property type="term" value="F:site-specific DNA-methyltransferase (cytosine-N4-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002941">
        <property type="entry name" value="DNA_methylase_N4/N6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017985">
        <property type="entry name" value="MeTrfase_CN4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001091">
        <property type="entry name" value="RM_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13370">
        <property type="entry name" value="RNA METHYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13370:SF3">
        <property type="entry name" value="TRNA (GUANINE(10)-N2)-METHYLTRANSFERASE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01555">
        <property type="entry name" value="N6_N4_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00508">
        <property type="entry name" value="S21N4MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00093">
        <property type="entry name" value="N4_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 8 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0680">Restriction system</keyword>
    <keyword evidence="4 8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA methylase N-4/N-6" evidence="9">
        <location>
            <begin position="27"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIF82911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="340" mass="38821" checksum="083DF6E64EF252CC" modified="2014-10-29" version="1">MAGDDPFQVLQGDARDIAKSLEPGTFRAIITSPPYFGHRHYGPDRGEIGQERDVERYLDALEGIFVACKRLLAEDGSLWIVIGDTRRRKEKLRVPHRLAERLSSAGYRFREDIIWYKKNNISSSSRDNFSQAYEYVLFFSKNAHSYADLDAVRVQGNEAVEGRNRVPPKEMLQFAPENPDRKEIERIADIIHNATAGTPISELPSTSEIARAYGYDPEKFCPTCYRKFKRHATRRRIGDHKHYPIFAVCNPNGKNPSNVWEIATRAHYGNEHFAIFPEELVEKIILFATKKGDFVLDPFCGRGTTGISAVSLGRRFVGIDLYRENVDRASKNILRAQQQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MN51</accession>
    <name>A0A075MN51_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Transketolase, beta subunit</fullName>
            <ecNumber evidence="15">2.2.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">NTE_00602</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">SR1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the transketolase family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.1" evidence="15"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699604.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MN51"/>
    <dbReference type="STRING" id="1459636.NTE_00602"/>
    <dbReference type="GeneID" id="41596465"/>
    <dbReference type="KEGG" id="nev:NTE_00602"/>
    <dbReference type="eggNOG" id="arCOG01053">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG05046">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_490605_0_0_2"/>
    <dbReference type="OrthoDB" id="25494at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016857">
        <property type="term" value="F:racemase and epimerase activity, acting on carbohydrates and derivatives"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004802">
        <property type="term" value="F:transketolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006091">
        <property type="term" value="P:generation of precursor metabolites and energy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046496">
        <property type="term" value="P:nicotinamide nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006163">
        <property type="term" value="P:purine nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044272">
        <property type="term" value="P:sulfur compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00429">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000191">
        <property type="entry name" value="ribulose-phosphate 3-epimerase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000056">
        <property type="entry name" value="Ribul_P_3_epim-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004076">
        <property type="entry name" value="PRK05581.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47514">
        <property type="entry name" value="TRANSKETOLASE N-TERMINAL SECTION-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47514:SF1">
        <property type="entry name" value="TRANSKETOLASE N-TERMINAL SECTION-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00834">
        <property type="entry name" value="Ribul_P_3_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01085">
        <property type="entry name" value="RIBUL_P_3_EPIMER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01086">
        <property type="entry name" value="RIBUL_P_3_EPIMER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="15" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Transketolase N-terminal" evidence="14">
        <location>
            <begin position="12"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AIF82683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="546" mass="61041" checksum="9D93048F03F1A4E7" modified="2014-10-29" version="1">MGFDMRYLELKRKVREVRMWAIQGIAEAGSGHPGASFSAAEIMSTLYFRRMRHDPKDPSWQERDYFINSKAHSAPGYYSTLAVAGYFPPEELKTLRKLGSRLQGHPVRYSERQKDHSVPGIEYSGGSEGIGLSVGVGIALASKLDGKKNRVYVMIGDGESNEGQIWEASMAAAKFKLDNLVAVLDRNRIQQDGFTEDIMPLDPAKNKWEAFNWQVFEVDGHRVEQLVDALNRAAQVKDKPVMIVANTVKGNGIRHMANNPQWHGKAPSKKQTPVLLEELESEYFIAPSIIAGEKENYEDKIRKVEREGVEMIHLDVMDGKFVPNTTFLADTIKRLRRVTALPFDAHLMIEKPLAHIDEYIDARCDVITVHAEACNEDEFVQIQDRCLAAGISPGIAINPKTDVPEWLYPHISNVDVVIVMSVNPGFAGQKFMPEVLPKMVAVNKKLREHGFKGYIEADGGIDSTTLPQVYDAGARIFVAGNAVYGNTDVHTAVIQLRHKAAVALERKLLDHATRLGIRSDWMKARKHILIPYASELGIEAELHAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNH9</accession>
    <name>A0A075MNH9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC-type nitrate/sulfonate/bicarbonate transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NTE_01037</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cell membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987180.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNH9"/>
    <dbReference type="STRING" id="1459636.NTE_01037"/>
    <dbReference type="GeneID" id="41596860"/>
    <dbReference type="KEGG" id="nev:NTE_01037"/>
    <dbReference type="eggNOG" id="arCOG00169">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046113_1_4_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="entry name" value="MetI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30151:SF0">
        <property type="entry name" value="ABC TRANSPORTER PERMEASE PROTEIN MJ0413-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30151">
        <property type="entry name" value="ALKANE SULFONATE ABC TRANSPORTER-RELATED, MEMBRANE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="MetI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="8">
        <location>
            <begin position="74"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF83111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="273" mass="29577" checksum="C474D5F417B39EA5" modified="2014-10-29" version="1">MMQQQQKTTEARRKNGNTTINDLASIALFLAAFGAAWQVVYLAGLFPAYSLPSPISVAKSFADLASEGSLGTGIAVTMGRLAAGFAISVAIGGTVGLAMVRFKDFGKTMSSFSVGLQSFPSIAWVPFSILLIGYNDFGILFVMVISSVFSVMMSTYSGIRNIPPIYVRAARNMGADGFVLFRHVMLPAATPTLIIGLRQAWSFAWHALVGAEILISLVGLGHILSVGRELNNMGWIMATMIVIFVIGMVVDRIVFFKLEERIRSRWGLNQHAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNK1</accession>
    <name>A0A075MNK1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699959.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNK1"/>
    <dbReference type="STRING" id="1459636.NTE_01063"/>
    <dbReference type="GeneID" id="41596883"/>
    <dbReference type="KEGG" id="nev:NTE_01063"/>
    <dbReference type="eggNOG" id="arCOG02926">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2152488_0_0_2"/>
    <dbReference type="OrthoDB" id="373606at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="111" mass="12321" checksum="56C1B0D242706D2B" modified="2014-10-29" version="1">MTTSQSMSVAVSGKVAAAFLSASIAMVVMGVLTFVRKDQQWLVPYGPAAQYGGIFVYSEITWAVLWMGLYIAMRNKERVGTIKFWLVFFLMSLAVATGLAESSLKWFPLPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNK4</accession>
    <name>A0A075MNK4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00708</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNK4"/>
    <dbReference type="KEGG" id="nev:NTE_00708"/>
    <dbReference type="HOGENOM" id="CLU_3322769_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="38" mass="4480" checksum="07A0FDB32A5CFF7F" modified="2014-10-29" version="1">MMMMIMSASYARRVNVNPSMNKHKFTNLCSLKEEKMIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNQ7</accession>
    <name>A0A075MNQ7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699417.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNQ7"/>
    <dbReference type="GeneID" id="41596252"/>
    <dbReference type="KEGG" id="nev:NTE_00360"/>
    <dbReference type="HOGENOM" id="CLU_2839204_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="72" mass="7467" checksum="863AB9EF72355B1B" modified="2014-10-29" version="1">MGLLTLVLIVAIVLVIIGIGADAFFSGLWTGAQKVGSNPIVQNITEQGKQFAKEAAQNATGKLQNATIGMPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNV4</accession>
    <name>A0A075MNV4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00290</name>
        <name evidence="2" type="ORF">NTE_01138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699369.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNV4"/>
    <dbReference type="GeneID" id="41596952"/>
    <dbReference type="KEGG" id="nev:NTE_00290"/>
    <dbReference type="KEGG" id="nev:NTE_01138"/>
    <dbReference type="HOGENOM" id="CLU_1631559_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="162" mass="18433" checksum="BBA89D1792AF8F16" modified="2014-10-29" version="1">MKYYLDSEISKVAIIKTVESETHKKIWDILAEKGGDLKLTPLQIRLLVHKSLENFSRLHKNYGILPDDVSLMPNVENMYANIWSGGNTLQIQVWVSIKKKNSPADGPPRGNDLRILSTSAKFATYIKTELLTFDHDFIAFEQEIRKTFGLDIINGGTIPHTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNW9</accession>
    <name>A0A075MNW9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00837</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNW9"/>
    <dbReference type="STRING" id="1459636.NTE_00837"/>
    <dbReference type="KEGG" id="nev:NTE_00837"/>
    <dbReference type="HOGENOM" id="CLU_3003277_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="61" mass="7016" checksum="B7DD30D62354816D" modified="2014-10-29" version="1">MHLWSKRSTVVSWSYIVVCKKCGYISAEKLPEQEAKDLRRSHLEGSHGCTISHITLMKVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNX1</accession>
    <name>A0A075MNX1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peroxiredoxin</fullName>
            <ecNumber evidence="6">1.11.1.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NTE_01148</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.11.1.15" evidence="6"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNX1"/>
    <dbReference type="STRING" id="1459636.NTE_01148"/>
    <dbReference type="KEGG" id="nev:NTE_01148"/>
    <dbReference type="eggNOG" id="arCOG00310">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_14_2_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03018">
        <property type="entry name" value="PRX_AhpE_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050455">
        <property type="entry name" value="Tpx_Peroxidase_subfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43110">
        <property type="entry name" value="THIOL PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43110:SF1">
        <property type="entry name" value="THIOL PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="5">
        <location>
            <begin position="31"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity" evidence="3">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF83221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="185" mass="20309" checksum="CD7CD5E1AD0A708E" modified="2014-10-29" version="1">MRKVYGDTSKNKKKLNKPRQKSATIPSSTPLQPGTRAPDFTLRSTPDKTVSLGEFRSRPVILAFYPADFSPVCGDEMALFNEILPEFNRFNAQLLGISVDNIWSHLAFSKARNLGFPLLSDFNPKGSVAQQYGVYRQGDGTAERALFVIDGDGVIRWSYVSPIGVNPGANGILAALESLDAKEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNY9</accession>
    <name>A0A075MNY9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, N-acetylglutamate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00787</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNY9"/>
    <dbReference type="STRING" id="1459636.NTE_00787"/>
    <dbReference type="KEGG" id="nev:NTE_00787"/>
    <dbReference type="HOGENOM" id="CLU_888358_0_0_2"/>
    <dbReference type="OrthoDB" id="43754at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="310" mass="34201" checksum="9902B81AC83DDC00" modified="2014-10-29" version="1">MREDDLEEADRIMRLAFGTFIGLPDPMSFAGDADYVYTRYRADPPAALVAEIDGKIAGSNFALHWGSVGVFGPLTVHPDFWDKGVARLLLEGTMDVFAKWQVSHAGLFTFAQSSKHVHLYQKFGFWPRFLTSIMSKPVDKNQSAARMIRYSQLAAAEKEQTVKACKALTGTIYDGLDLKTEIYSVDKQALGDTILIYDNDNADSLAGFAVCHCGPGTEAGSGNCYVKFGAAAPGQDSAGERFEHLLDGCESFAGSQGLSRIIAGVNTGRHDAYKRMIARKFRTDIQGVAMHRPDEPGYNRKDVYLMDDWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MP25</accession>
    <name>A0A075MP25_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00839</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699788.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MP25"/>
    <dbReference type="GeneID" id="41596683"/>
    <dbReference type="KEGG" id="nev:NTE_00839"/>
    <dbReference type="HOGENOM" id="CLU_203621_0_0_2"/>
    <dbReference type="OrthoDB" id="11766at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="70" mass="8331" checksum="9B4303E664A3EDE8" modified="2014-10-29" version="1">MAIDSDAEQIFRENYAQELRKKKQSELEDERKKVNQQGMKTPGRRGEAIKHEEIDKEIVRRYKLGQKKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPF4</accession>
    <name>A0A075MPF4_9ARCH</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00591</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699595.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPF4"/>
    <dbReference type="GeneID" id="41596454"/>
    <dbReference type="KEGG" id="nev:NTE_00591"/>
    <dbReference type="HOGENOM" id="CLU_2420150_0_0_2"/>
    <dbReference type="OrthoDB" id="6556at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="91" mass="10213" checksum="70ABEF91B0B6B917" modified="2014-10-29" version="1">MPKELSEAQAWEIVNPVCRELFELVNEKMVRFVSATESDNGTYAINLKSSRIHLASRGFKDSIGDIEYGEGKLRIGLRANGRPGNIFIDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPJ3</accession>
    <name>A0A075MPJ3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00637</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699632.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPJ3"/>
    <dbReference type="STRING" id="1459636.NTE_00637"/>
    <dbReference type="GeneID" id="41596500"/>
    <dbReference type="KEGG" id="nev:NTE_00637"/>
    <dbReference type="HOGENOM" id="CLU_156590_1_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="101" mass="12080" checksum="5BA72827D02322BE" modified="2014-10-29" version="1">MIVEYIHYEIPGERQQEFEAAYNDAAKSLMSSVHCQKYELSHCVENPDLYILRIEWDSLDGHMKGFRGSREFGRFFDLVKPFFNDIQEMQHYEPTRVRGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPL3</accession>
    <name>A0A075MPL3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00677</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699664.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPL3"/>
    <dbReference type="GeneID" id="41596535"/>
    <dbReference type="KEGG" id="nev:NTE_00677"/>
    <dbReference type="HOGENOM" id="CLU_2565541_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="81" mass="9254" checksum="E740393C1A10FB0B" modified="2014-10-29" version="1">MTKTTITANKKVLTFVLLALGVAMIGSVMAAPTAAFAVGGDHYDHHDHHDDGHHHHHHHHDGDHDHRHHHKHHDHDDDYDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPT5</accession>
    <name>A0A075MPT5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">30S ribosomal protein S24e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_00784</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699749.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPT5"/>
    <dbReference type="STRING" id="1459636.NTE_00784"/>
    <dbReference type="GeneID" id="41596634"/>
    <dbReference type="KEGG" id="nev:NTE_00784"/>
    <dbReference type="eggNOG" id="arCOG04182">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1976424_0_0_2"/>
    <dbReference type="OrthoDB" id="10967at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053709">
        <property type="entry name" value="eRP_eS24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001976">
        <property type="entry name" value="Ribosomal_eS24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01282">
        <property type="entry name" value="Ribosomal_S24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF82862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="126" mass="13973" checksum="8BE58DABC967EAD4" modified="2014-10-29" version="1">MSQEAVVMLEDRKNSLLSRREVKALFRGAAGKLKKTEAAEQVASQLGVDKKIVIPINLVCETGMTDVHAVFYVYENEEAAKKQLPRYRMLRTMPKADRKKLLDEEKAAKLKAKQAAAADAKGGAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPZ8</accession>
    <name>A0A075MPZ8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ketol-acid reductoisomerase (NADP(+))</fullName>
            <shortName evidence="11">KARI</shortName>
            <ecNumber evidence="11">1.1.1.86</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Acetohydroxy-acid isomeroreductase</fullName>
            <shortName evidence="11">AHIR</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Alpha-keto-beta-hydroxylacyl reductoisomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ilvC</name>
        <name evidence="15" type="ORF">NTE_01112</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate + NAD(+) = (2S)-2-acetolactate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:30627"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="1.1.1.383"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) = (2S)-2-acetolactate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22068"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="1.1.1.383"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) = (2S)-2-acetolactate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22068"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="1.1.1.86"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+) = (S)-2-ethyl-2-hydroxy-3-oxobutanoate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13493"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:49256"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.86"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11 12">Belongs to the ketol-acid reductoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.86" evidence="11"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699996.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPZ8"/>
    <dbReference type="STRING" id="1459636.NTE_01112"/>
    <dbReference type="GeneID" id="41596927"/>
    <dbReference type="KEGG" id="nev:NTE_01112"/>
    <dbReference type="eggNOG" id="arCOG04465">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033821_0_1_2"/>
    <dbReference type="OrthoDB" id="6064at2157"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00056"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004455">
        <property type="term" value="F:ketol-acid reductoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000023">
        <property type="entry name" value="Ketol-acid reductoisomerase (NADP(+))"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00435">
        <property type="entry name" value="IlvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013023">
        <property type="entry name" value="KARI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000506">
        <property type="entry name" value="KARI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013116">
        <property type="entry name" value="KARI_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014359">
        <property type="entry name" value="KARI_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00465">
        <property type="entry name" value="ilvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004017">
        <property type="entry name" value="PRK05479.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21371">
        <property type="entry name" value="KETOL-ACID REDUCTOISOMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21371:SF1">
        <property type="entry name" value="KETOL-ACID REDUCTOISOMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01450">
        <property type="entry name" value="KARI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07991">
        <property type="entry name" value="KARI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000116">
        <property type="entry name" value="IlvC_gammaproteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51851">
        <property type="entry name" value="KARI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51850">
        <property type="entry name" value="KARI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11 12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 11 12" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="15" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 11 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0521">NADP</keyword>
    <keyword evidence="7 11 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KARI N-terminal Rossmann" evidence="13">
        <location>
            <begin position="3"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="KARI C-terminal knotted" evidence="14">
        <location>
            <begin position="184"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="26"/>
            <end position="29"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 12">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 12">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 12">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 12">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 12">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 12">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00050504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AIF83185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="333" mass="37332" checksum="23C32A91BE4CF41E" modified="2014-10-29" version="1">MPAKKWLDKEVSLDPIKKQTIAVIGYGIQGRAQASNMKDSGLNVIVGLRKGGKTWKQAEAEGHKVMEVADAAKAADIIHILIPDMEQEETYKRDIAKHVTAGKALSFSHGAAIHWKWIVPPKDVDVIMVAPKGPGQRVRELYQDGFGIPSLVAVHQDHTGKAWDRVLAMAKGIGSTRPGVLKTDFKEEVETDWFGEQVDLCGGTHALVMNAFETLVEAGYQPEVAYFECLHELKLITDLVQKYGLTGMYNRVSETARYGGLTRGPRVVDKDAKNKMKQVLNEIQSGEFAEEWVSKYKKEGKHSFARYMKDIENHQIEKVGKDLRKMMWPDQET</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQA9</accession>
    <name>A0A075MQA9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nitroreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_01315</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nitroreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987197.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQA9"/>
    <dbReference type="STRING" id="1459636.NTE_01315"/>
    <dbReference type="GeneID" id="41597117"/>
    <dbReference type="KEGG" id="nev:NTE_01315"/>
    <dbReference type="eggNOG" id="arCOG00288">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070764_6_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02138">
        <property type="entry name" value="TdsD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="entry name" value="NADH Oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43673">
        <property type="entry name" value="NAD(P)H NITROREDUCTASE YDGI-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43673:SF10">
        <property type="entry name" value="NADH DEHYDROGENASE_NAD(P)H NITROREDUCTASE XCC3605-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="FMN-dependent nitroreductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="3">
        <location>
            <begin position="20"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF83383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="203" mass="22860" checksum="D8494B9E0EC9639A" modified="2014-10-29" version="1">MLQDIMDKSAKADYPINALIAKRWSARAFSDRPVEKQKIMSLLEAARWAPSSSNEQPWRFIVFTIENGSKERMEEARSVLSEGNSYAKRAPVLMCAAAKKTYTHNDKDNRHHMHDVGAATAYMFLEAYNQGLAMHVMGGFDAEKARQLFGIPDGFEPATMIAIGYYGNPETLPKKPREKELAPRSRKPAGEWAFFGQWGSSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQC9</accession>
    <name>A0A075MQC9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">O-6-methylguanine DNA methyltransferase</fullName>
            <ecNumber evidence="12">2.1.1.63</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NTE_01340</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a thymidine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:53428"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:13555"/>
            <dbReference type="Rhea" id="RHEA-COMP:13556"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:137386"/>
            <dbReference type="ChEBI" id="CHEBI:137387"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] = S-methyl-L-cysteinyl-[protein] + a 2'-deoxyguanosine in DNA</text>
            <dbReference type="Rhea" id="RHEA:24000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:11367"/>
            <dbReference type="Rhea" id="RHEA-COMP:11368"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:85445"/>
            <dbReference type="ChEBI" id="CHEBI:85448"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="2.1.1.63" evidence="12"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_338031185.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQC9"/>
    <dbReference type="STRING" id="1459636.NTE_01340"/>
    <dbReference type="GeneID" id="41597139"/>
    <dbReference type="KEGG" id="nev:NTE_01340"/>
    <dbReference type="eggNOG" id="arCOG02724">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_52_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003908">
        <property type="term" value="F:methylated-DNA-[protein]-cysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000410">
        <property type="entry name" value="ADA regulatory protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.10.10">
        <property type="entry name" value="DNA Methylphosphotriester Repair Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.70">
        <property type="entry name" value="Methylated DNA-protein cysteine methyltransferase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035451">
        <property type="entry name" value="Ada-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004026">
        <property type="entry name" value="Ada_DNA_repair_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016221">
        <property type="entry name" value="Bifunct_regulatory_prot_Ada"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001497">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036631">
        <property type="entry name" value="MGMT_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00589">
        <property type="entry name" value="ogt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011964">
        <property type="entry name" value="PRK15435.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10815:SF14">
        <property type="entry name" value="BIFUNCTIONAL TRANSCRIPTIONAL ACTIVATOR_DNA REPAIR ENZYME ADA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10815">
        <property type="entry name" value="METHYLATED-DNA--PROTEIN-CYSTEINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02805">
        <property type="entry name" value="Ada_Zn_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000409">
        <property type="entry name" value="Ada"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57884">
        <property type="entry name" value="Ada DNA repair protein, N-terminal domain (N-Ada 10)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53155">
        <property type="entry name" value="Methylated DNA-protein cysteine methyltransferase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="Methylated DNA-protein cysteine methyltransferase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00374">
        <property type="entry name" value="MGMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="11">
        <location>
            <begin position="95"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIF83408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="364" mass="39828" checksum="CAC5711E3054DB95" modified="2014-10-29" version="1">MSMTPKNAQLAAATEGDPRWASVVARDTEADGTFYYSVKTTGVYCRPSCAARRARPENVRFHMTREEAEKAGLRPCKRCKPNQPSLTEQHAAKVTQACRLIEESENAPSLKELAKHAGMSTYHFHRVFKKVAGLTPREYALAHRAKRIRSELGQSETVTEAIYDAGYSSNRRFYETSNEVLGMTPSNYRAGGASTEIHFAVGECSLGSILVAQSEHGVCAILLGDDPDELVRDLQDRFPRANLIGGDAKFEQLVSKVVGFVEAPALGLDLPLDIRGTAFQQRVWQALREIPAGSTASYTDIANRIGSPKSVRAVAQACAANALAVAIPCHRVVRNDGALSGYRWGVERKRVLLKKEARAQTHGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQK0</accession>
    <name>A0A075MQK0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7 8">Prefoldin subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">GimC subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pfdA</name>
        <name evidence="11" type="ORF">NTE_01291</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 7">Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 7">Heterohexamer of two alpha and four beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the prefoldin alpha subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700145.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQK0"/>
    <dbReference type="STRING" id="1459636.NTE_01291"/>
    <dbReference type="GeneID" id="41597094"/>
    <dbReference type="KEGG" id="nev:NTE_01291"/>
    <dbReference type="eggNOG" id="arCOG01341">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091867_1_0_2"/>
    <dbReference type="OrthoDB" id="10045at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23160">
        <property type="entry name" value="Prefoldin_alpha_GimC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00308">
        <property type="entry name" value="PfdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011599">
        <property type="entry name" value="PFD_alpha_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00293">
        <property type="entry name" value="prefoldin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12674">
        <property type="entry name" value="PREFOLDIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12674:SF2">
        <property type="entry name" value="PREFOLDIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="128"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="NCBIfam" id="TIGR00293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIF83360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="175" mass="19598" checksum="F89FFD2726E9CCDC" modified="2014-10-29" version="1">MHTDDSSGHSHSHDHDHSHPHDHPHDHGHSHEQAQMLEQQLNEMVQQGRVLEAYMNDVMNRQAAVGRMLEEARIASATIQGISAETESETLMPVGIGVYVKTSVPAAKKLLVSLGSGVTIEKSRDDALNYVEARIKEYEVAMRQLEAQRQQIAMQMEQVQQQVNMMLKAAQSRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQL7</accession>
    <name>A0A075MQL7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SpaA-like prealbumin fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01312</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700162.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQL7"/>
    <dbReference type="STRING" id="1459636.NTE_01312"/>
    <dbReference type="GeneID" id="41597114"/>
    <dbReference type="KEGG" id="nev:NTE_01312"/>
    <dbReference type="HOGENOM" id="CLU_716886_0_0_2"/>
    <dbReference type="OrthoDB" id="10540at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041033">
        <property type="entry name" value="SpaA_PFL_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17802">
        <property type="entry name" value="SpaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpaA-like prealbumin fold" evidence="1">
        <location>
            <begin position="51"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="385" mass="40204" checksum="148BA2D72BECE3CC" modified="2014-10-29" version="1">MTPKQSLALAIALAAAVTVAAIVVSLPREQNMPGAAQDGAKDAGSITIATVSGGSLLTGATYSITPNPYTGQGTYSVQDGGGDDANPAAGMILLSRVKSGNYTVSQQQAPPGYVRDQVPKSIAVNNNNNNSATASFSNAGLGQQPDNSTLQVHNILYTAKFECGTISGDEGPLRPGHYDTDIGILNKQDFSVKFTWNAIVNNGKTTNSILKTLEPQTSTGIVCKDLRKLFGGNDTSFVEGFVLVNVPVDSGLLSTLSGGTAVVGRQGTSVDILDVQVFYTANALEQLPHEVLVDKIVFTVTNDTSGKIPKEMIGKTLDVTVRSGFNDISDPVEKVREALGEKYGLDTQQRASLAVKVDSISVGAGTMIDDHALSLSRVPPQASSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQP5</accession>
    <name>A0A075MQP5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Zn-finger containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01469</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700290.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQP5"/>
    <dbReference type="STRING" id="1459636.NTE_01469"/>
    <dbReference type="GeneID" id="41597262"/>
    <dbReference type="KEGG" id="nev:NTE_01469"/>
    <dbReference type="eggNOG" id="arCOG00578">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1965441_0_0_2"/>
    <dbReference type="OrthoDB" id="26305at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009563">
        <property type="entry name" value="SSSCA1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06677">
        <property type="entry name" value="Auto_anti-p27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="127" mass="13109" checksum="8C796F963AA77343" modified="2014-10-29" version="1">MSSSATADAGGVRIKSAASALLKGGTLVSEPCPKCGGVQVRLAGRTSCINCGNESVPQEEQQKVAVVPSAQAATTGLGPSAAIVEGKIAELASELRDEKDTAIQRQKAELLEAYLRILEKMRALSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQS8</accession>
    <name>A0A075MQS8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01377</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQS8"/>
    <dbReference type="STRING" id="1459636.NTE_01377"/>
    <dbReference type="KEGG" id="nev:NTE_01377"/>
    <dbReference type="eggNOG" id="arCOG08731">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148455_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="172" mass="19553" checksum="62D416FAFB755C48" modified="2014-10-29" version="1">MAVYRHNKALILCLQRYCAVPKRNFSTLDEFKANLHKEGATLVEFSGGKVPCILVSPKKYEEMLGKVYGRRVSADTLLDIFYDGRDVFVDVNIKFRDTDFEGNFLLYANDMLEWFEALAESGMMAMGPSETTYTNSQNIFMIQLPKKDAAEKALEIIKTNAKNRVVRGMQDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQW7</accession>
    <name>A0A075MQW7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700345.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQW7"/>
    <dbReference type="STRING" id="1459636.NTE_01540"/>
    <dbReference type="GeneID" id="41597325"/>
    <dbReference type="KEGG" id="nev:NTE_01540"/>
    <dbReference type="eggNOG" id="arCOG02994">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103066_3_0_2"/>
    <dbReference type="OrthoDB" id="190812at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053146">
        <property type="entry name" value="QDO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36440">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_8G07350)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36440:SF1">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_8G07350)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-2" evidence="1">
        <location>
            <begin position="64"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="184" mass="20005" checksum="EEFEE89423760BAD" modified="2014-10-29" version="1">MSKKTNVPEQPASATLPADNLERNLAVAQPNTNQKLPHIGVVGDTYTILLTGKDTGGRFCLIDMHIPPGGGPPPHRHDFEETFIMLEGELEATFRGTKRAVRAGETINIPANAPHQFRNSSSQPVRMLCICSPPGQEDFFMEVGVPVATRTTPPPMLDEAAQAEFRAKAAALAPKYRTELLQHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MR80</accession>
    <name>A0A075MR80_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NTE_01537</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700342.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MR80"/>
    <dbReference type="STRING" id="1459636.NTE_01537"/>
    <dbReference type="GeneID" id="41597322"/>
    <dbReference type="KEGG" id="nev:NTE_01537"/>
    <dbReference type="eggNOG" id="arCOG02643">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_15_12_2"/>
    <dbReference type="OrthoDB" id="135877at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000141">
        <property type="entry name" value="TetR family transcriptional regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.10">
        <property type="entry name" value="Tetracycline Repressor, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039538">
        <property type="entry name" value="BetI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050109">
        <property type="entry name" value="HTH-type_TetR-like_transc_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30328:SF54">
        <property type="entry name" value="HTH-TYPE TRANSCRIPTIONAL REPRESSOR SCO4008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30328">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13977">
        <property type="entry name" value="TetR_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="Tetracyclin repressor-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="6">
        <location>
            <begin position="10"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="5">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF83600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="196" mass="22102" checksum="C6E373707430BD8E" modified="2014-10-29" version="1">MPKVTSAHKAEVRDRIVQAAIESFSQTGYDKTKMDDISRRLGLSKGTLYLYFKSKEDLFLGVCEMSLKAGDKHDAHLFTKKENAASDAEEIFDNIRRRERGNDRVMLEMVVESTRNPRLKKAMYEYHLKVHEHVLEGLKKKVEEGFIRKDVDVAGIAIALVALYDGLAVNRMLGLNDSVNKKAWVAMLKAVIAGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRI5</accession>
    <name>A0A075MRI5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GTP-dependent dephospho-CoA kinase</fullName>
            <ecNumber evidence="6">2.7.1.237</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Dephospho-coenzyme A kinase</fullName>
            <shortName evidence="6">DPCK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NTE_01707</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the GTP-dependent phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>3'-dephospho-CoA + GTP = GDP + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61156"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57328"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="2.7.1.237"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; coenzyme A biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the GTP-dependent DPCK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.237" evidence="6"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385257.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRI5"/>
    <dbReference type="STRING" id="1459636.NTE_01707"/>
    <dbReference type="GeneID" id="41597477"/>
    <dbReference type="KEGG" id="nev:NTE_01707"/>
    <dbReference type="eggNOG" id="arCOG04076">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120795_1_0_2"/>
    <dbReference type="OrthoDB" id="15447at2157"/>
    <dbReference type="UniPathway" id="UPA00241"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00590">
        <property type="entry name" value="Dephospho_CoA_kinase_GTP_dep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007164">
        <property type="entry name" value="GTP-dep_dephospho-CoA_kin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40732:SF1">
        <property type="entry name" value="GTP-DEPENDENT DEPHOSPHO-COA KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40732">
        <property type="entry name" value="UPF0218 PROTEIN TK1697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04019">
        <property type="entry name" value="DUF359"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006533">
        <property type="entry name" value="UCP006533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF83768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="168" mass="18308" checksum="D29F8286FC31F088" modified="2014-10-29" version="1">MRQEDLEELKKPFGTLVPDAQVTKEKISALVKGAKKIVAVGDATTERLLGFGITPDLAVVDGKERRLLREYPRHDAKEMRCTNPAGTISQAAVDLLKKALVEKKPVLVVVEGEEDLLALPVFAMALENSVVLYGQPLEGMVAVKITPAKRKQAKDLMDRIGVEKHGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRK9</accession>
    <name>A0A075MRK9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">D-aminoacyl-tRNA deacylase</fullName>
            <ecNumber evidence="4">3.1.1.96</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">dtdA</name>
        <name evidence="5" type="ORF">NTE_01385</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a D-aminoacyl-tRNA + H2O = a tRNA + a D-alpha-amino acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13953"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:10124"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59871"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:79333"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>glycyl-tRNA(Ala) + H2O = tRNA(Ala) + glycine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53744"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:13640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DtdA deacylase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.96" evidence="4"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700222.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRK9"/>
    <dbReference type="STRING" id="1459636.NTE_01385"/>
    <dbReference type="GeneID" id="41597181"/>
    <dbReference type="KEGG" id="nev:NTE_01385"/>
    <dbReference type="eggNOG" id="arCOG01616">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056464_1_0_2"/>
    <dbReference type="OrthoDB" id="9863at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051499">
        <property type="term" value="F:D-aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106026">
        <property type="term" value="F:Gly-tRNA(Ala) deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10700">
        <property type="entry name" value="AF0625-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.50">
        <property type="entry name" value="AF0625-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00562">
        <property type="entry name" value="Deacylase_DtdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018033">
        <property type="entry name" value="Deacylase_DtdA_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007508">
        <property type="entry name" value="DtdA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34667">
        <property type="entry name" value="D-AMINOACYL-TRNA DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34667:SF1">
        <property type="entry name" value="D-AMINOACYL-TRNA DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04414">
        <property type="entry name" value="tRNA_deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016210">
        <property type="entry name" value="UCP016210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142535">
        <property type="entry name" value="AF0625-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF83452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="273" mass="29279" checksum="DFE1EB0A9A533301" modified="2014-10-29" version="1">MRDFILVASSQDLAGVTMSDYLRSKQGFAPDGLHDRKEGQSFSSPAHSSAKLYVANESLLTLETLDTTYPDARAFVFLSKHRSDSGIPTLTCHCTGNFADAPFGGNPKEMAVALPSLQKAYLKAITNAQVPGYDVIIEATHHGPTSLKKPVLFVELGSSEKQWADRGAAKAMCDSLLAVLANGIKPCEKVAVAIGGTHYPTKFNKLLLESEFGLAAVASKHALDAIDEAMLAQMIEKSVEKVTHIVLDAKGLGSHKDRIMRLAENTGLAVLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRN6</accession>
    <name>A0A075MRN6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01669</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRN6"/>
    <dbReference type="KEGG" id="nev:NTE_01669"/>
    <dbReference type="HOGENOM" id="CLU_3112876_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="50" mass="5889" checksum="CE7385FABBEA0A0C" modified="2014-10-29" version="1">MISSSDFRVIVSEPLKSISFQNYMKKEKRRQLLVDVILTWIVLNCDCDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRP7</accession>
    <name>A0A075MRP7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_01772</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700534.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRP7"/>
    <dbReference type="STRING" id="1459636.NTE_01772"/>
    <dbReference type="GeneID" id="41597541"/>
    <dbReference type="KEGG" id="nev:NTE_01772"/>
    <dbReference type="HOGENOM" id="CLU_175243_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="21"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF83833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="89" mass="10149" checksum="EB383BF8BC5D037A" modified="2014-10-29" version="1">MPRKLTETEKKRIAGRAAKQKRLAEKAAKAQAEELARLEEIKQAEEQHEEFEAARRKYLAESQAQASINEVRMLASMKQARGLLKLAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRS8</accession>
    <name>A0A075MRS8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LPPG:FO 2-phospho-L-lactate transferase</fullName>
            <ecNumber evidence="3">2.7.8.28</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_01463</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.8.28" evidence="3"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700284.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRS8"/>
    <dbReference type="STRING" id="1459636.NTE_01463"/>
    <dbReference type="GeneID" id="41597256"/>
    <dbReference type="KEGG" id="nev:NTE_01463"/>
    <dbReference type="eggNOG" id="arCOG04395">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055795_1_0_2"/>
    <dbReference type="OrthoDB" id="59563at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043743">
        <property type="term" value="F:LPPG:FO 2-phospho-L-lactate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07186">
        <property type="entry name" value="CofD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.240">
        <property type="entry name" value="CofD-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10680">
        <property type="entry name" value="CofD-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01257">
        <property type="entry name" value="CofD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002882">
        <property type="entry name" value="CofD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038136">
        <property type="entry name" value="CofD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010115">
        <property type="entry name" value="FbiA/CofD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01819">
        <property type="entry name" value="F420_cofD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43007">
        <property type="entry name" value="2-PHOSPHO-L-LACTATE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43007:SF1">
        <property type="entry name" value="2-PHOSPHO-L-LACTATE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01933">
        <property type="entry name" value="CofD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142338">
        <property type="entry name" value="CofD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF83527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="329" mass="35579" checksum="D970DDF8CA1D09A1" modified="2014-10-29" version="1">MIAVIAGGTGSVKLVRGLALLLEGKRPKEEGMSVIANVGDNIWLYGLYICPDIDTLVYGLAGILDEKRGWGIRGDTFSFLDQMKRSGVDAWFGLGDRDLATHVLRTEMMKRGGKSLTEVTAYFAEKFRVAADSKVLPATDSEVETMIMTYDDNDGDAAVAAGEMHLQEFWVKNAGRPKVRGVRYRGIEQAQATKQALAAIKNADRIIIAPGNPVSSIGPTLALKDIKAALAKRRADVVAVSPMIGNAAVSGPAAKYLSAVGVQASAAGVAEFYKEVAGSIVIDGRDREVASKTIKRLDMDVYETNITMQGRQDEVRLGRYLLLLLRKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRT5</accession>
    <name>A0A075MRT5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01744</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700507.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRT5"/>
    <dbReference type="STRING" id="1459636.NTE_01744"/>
    <dbReference type="GeneID" id="41597514"/>
    <dbReference type="KEGG" id="nev:NTE_01744"/>
    <dbReference type="HOGENOM" id="CLU_2985804_0_0_2"/>
    <dbReference type="OrthoDB" id="9392at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="60" mass="6820" checksum="A95AAB2E721E69C9" modified="2014-10-29" version="1">MMNCPVCGAIMVWLNGSVLHDPPTKFYECRHCKINVTKLADGTIETEQQQPQEEQQQATQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRU8</accession>
    <name>A0A075MRU8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RNase P subunit p30</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01759</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700522.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRU8"/>
    <dbReference type="STRING" id="1459636.NTE_01759"/>
    <dbReference type="GeneID" id="41597529"/>
    <dbReference type="KEGG" id="nev:NTE_01759"/>
    <dbReference type="HOGENOM" id="CLU_1922677_0_0_2"/>
    <dbReference type="OrthoDB" id="379752at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="131" mass="14879" checksum="8FE514F1CB2CF398" modified="2014-10-29" version="1">MKYDYLIVSENIDEASRADILVLRDFRRAKERLKKKAKGGGAGIEITVQQARKMDAIGVARWIVDAHDLYEFCQSSGFQFILSSGAGSPSEVVSGQSFDAMLKMTEIDPQKHWRELAGWLESRLERRVRLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRU9</accession>
    <name>A0A075MRU9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acetolactate synthase small subunit</fullName>
            <shortName evidence="6">AHAS</shortName>
            <shortName evidence="6">ALS</shortName>
            <ecNumber evidence="6">2.2.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Acetohydroxy-acid synthase small subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NTE_02177</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 pyruvate + H(+) = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Dimer of large and small chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the acetolactate synthase small subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="6"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700844.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRU9"/>
    <dbReference type="STRING" id="1459636.NTE_02177"/>
    <dbReference type="GeneID" id="41597901"/>
    <dbReference type="KEGG" id="nev:NTE_02177"/>
    <dbReference type="eggNOG" id="arCOG04445">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055003_1_3_2"/>
    <dbReference type="OrthoDB" id="85792at2157"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990610">
        <property type="term" value="F:acetolactate synthase regulator activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04878">
        <property type="entry name" value="ACT_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acetolactate synthase small subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1150">
        <property type="entry name" value="ACT-like. Chain A, domain 2"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR004789">
        <property type="entry name" value="Acetalactate_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027271">
        <property type="entry name" value="Acetolactate_synth/TF_NikR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019455">
        <property type="entry name" value="Acetolactate_synth_ssu_C"/>
    </dbReference>
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        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039557">
        <property type="entry name" value="AHAS_ACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054480">
        <property type="entry name" value="AHAS_small-like_ACT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00119">
        <property type="entry name" value="acolac_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008864">
        <property type="entry name" value="PRK11895.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30239">
        <property type="entry name" value="ACETOLACTATE SYNTHASE SMALL SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30239:SF0">
        <property type="entry name" value="ACETOLACTATE SYNTHASE SMALL SUBUNIT 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22629">
        <property type="entry name" value="ACT_AHAS_ss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10369">
        <property type="entry name" value="ALS_ss_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="7">
        <location>
            <begin position="10"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF84231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="167" mass="18767" checksum="0DE27DAF11933D37" modified="2014-10-29" version="1">MENSNNELYIVSAIVENKPGVLFRVTNLFRARNFNIESITVGTTEQQDLSRMTITTSSDEKTLDQLVKQLRKLIDVVEVKVLDTDKTVYRELALIKMKAVDPTTRSEIMNYANIFRGNILDIGKETITVEITGTPDKIDAFKNLVDQYGITQLARTGVSALPRGVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MS26</accession>
    <name>A0A075MS26_9ARCH</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00122</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MS26"/>
    <dbReference type="KEGG" id="nev:NTE_00122"/>
    <dbReference type="HOGENOM" id="CLU_203622_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="69" mass="7371" checksum="5C719E3561C5E74B" modified="2014-10-29" version="1">MFKIMSLIVGGIVLMAVGVYVLSTASIQFPSIQWPQIQWPDVNWVIVGWVVIVGGLVSAGTGVIASRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MS65</accession>
    <name>A0A075MS65_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator with CheY-like receiver, AAA-type ATPase, and DNA-binding domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_02333</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700967.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MS65"/>
    <dbReference type="STRING" id="1459636.NTE_02333"/>
    <dbReference type="GeneID" id="41598049"/>
    <dbReference type="KEGG" id="nev:NTE_02333"/>
    <dbReference type="eggNOG" id="arCOG02391">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_8_2"/>
    <dbReference type="OrthoDB" id="10883at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00156">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050595">
        <property type="entry name" value="Bact_response_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44591:SF3">
        <property type="entry name" value="RESPONSE REGULATORY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44591">
        <property type="entry name" value="STRESS RESPONSE REGULATOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="8"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF84386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="128" mass="14588" checksum="F06487EDC7DB256A" modified="2014-10-29" version="1">MEQSGTKSILIVDDEKDILTVIEQMLQELNIIVDSFTNPKKALEWFQTNPTKYDLIISDFRMPQMSGLDFIHGIRQLNSAVNIVVMSAFDPSKEEIDSAKSQLRVSEIITKPFNLAQFLDLIKRNMGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSA5</accession>
    <name>A0A075MSA5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSA5"/>
    <dbReference type="STRING" id="1459636.NTE_01625"/>
    <dbReference type="KEGG" id="nev:NTE_01625"/>
    <dbReference type="HOGENOM" id="CLU_1987513_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="125" mass="14557" checksum="F44B89E11307D194" modified="2014-10-29" version="1">MFKQKFWYAEVLTVLAILNLPALAINYFEPENWYVWYALAVVAFATMVFSLRKIRRIEMFKSPAWSWEILVILITFVFVHRLLLGIAGGTHQGYFVSTLLQIPSAGIPFLVAWLLHRVPEERRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSB9</accession>
    <name>A0A075MSB9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphoribosylformylglycinamidine synthase subunit PurQ</fullName>
            <shortName evidence="8">FGAM synthase</shortName>
            <ecNumber evidence="8">6.3.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Formylglycinamide ribonucleotide amidotransferase subunit I</fullName>
            <shortName evidence="8">FGAR amidotransferase I</shortName>
            <shortName evidence="8">FGAR-AT I</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Glutaminase PurQ</fullName>
            <ecNumber evidence="8">3.5.1.2</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Phosphoribosylformylglycinamidine synthase subunit I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">purQ</name>
        <name evidence="9" type="ORF">NTE_01995</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + L-glutamine + ATP + H2O = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + L-glutamate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17129"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="6.3.5.3" evidence="8"/>
    <dbReference type="EC" id="3.5.1.2" evidence="8"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700702.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSB9"/>
    <dbReference type="STRING" id="1459636.NTE_01995"/>
    <dbReference type="GeneID" id="41597742"/>
    <dbReference type="KEGG" id="nev:NTE_01995"/>
    <dbReference type="eggNOG" id="arCOG00102">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001031_3_1_2"/>
    <dbReference type="OrthoDB" id="6486at2157"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01740">
        <property type="entry name" value="GATase1_FGAR_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00421">
        <property type="entry name" value="PurQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010075">
        <property type="entry name" value="PRibForGlyAmidine_synth_PurQ"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01737">
        <property type="entry name" value="FGAM_synth_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002957">
        <property type="entry name" value="PRK03619.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47552">
        <property type="entry name" value="PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE SUBUNIT PURQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47552:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE SUBUNIT PURQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13507">
        <property type="entry name" value="GATase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001586">
        <property type="entry name" value="FGAM_synth_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01211">
        <property type="entry name" value="GATase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF84053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="231" mass="25271" checksum="34AE024A266DC440" modified="2014-10-29" version="1">MKIGIAVFPGSNCDRDVHHVLNKVVGIQADFIWHTKDRISGYDAMVIPGGFAFGDRLRAGIIAAHSPIVQEVKRMAKDGMPVLGICNGFQILVESGLLPGALMMNDSLRFVCRWTKVKVENNRTPFTGQFAKRQVFDIPVAHGEGRYVADSAILKELRKKNQVVLQYSNDDPNGSTDLIAAICNEQGNVMGMMPHPERASESLLSATGANDAITVFRSLASYLEKEQKAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSE8</accession>
    <name>A0A075MSE8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02031</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700730.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSE8"/>
    <dbReference type="STRING" id="1459636.NTE_02031"/>
    <dbReference type="GeneID" id="41597773"/>
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    <dbReference type="HOGENOM" id="CLU_1639893_0_0_2"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="161" mass="18170" checksum="11725D6FF6009281" modified="2014-10-29" version="1">MSKKEEYLQRRTKGLRIVTDILFWSVRDAGPTLVSYVVGKGVGVKPPEQLVASMIFLYNAIRPLNPGYGFNLDDAAPYKHVAEISPRAVFLIQGRLDDVVLHNSANRLYNAAASPKEIWSGMDVRHCEASVKQGPEFVEKLHSLRNTLVWQILQTFDKKCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSL7</accession>
    <name>A0A075MSL7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
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        <lineage>
            <taxon>Archaea</taxon>
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            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="AlphaFoldDB" id="A0A075MSL7"/>
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    <dbReference type="KEGG" id="nev:NTE_02069"/>
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        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="140255at2157"/>
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        <property type="component" value="Chromosome"/>
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    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ArnR1-like_HTH"/>
    </dbReference>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14947">
        <property type="entry name" value="HTH_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ArnR1-like winged helix-turn-helix" evidence="1">
        <location>
            <begin position="7"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="106" mass="12171" checksum="EE7561FBEFB412CF" modified="2014-10-29" version="1">MKRTNNRTRFEIIRDILDLCLVPQKKTHIMSRANLSYEQTNYYLAVLIENGLLENGRREGVSDLRHKQYANTTEKGRKVLQALASTIEATDSIFATRLTTKLQAMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSQ2</accession>
    <name>A0A075MSQ2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00297</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699375.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSQ2"/>
    <dbReference type="GeneID" id="41596203"/>
    <dbReference type="KEGG" id="nev:NTE_00297"/>
    <dbReference type="HOGENOM" id="CLU_779885_0_0_2"/>
    <dbReference type="OrthoDB" id="386245at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="355" mass="39212" checksum="1A10C6313718CBBA" modified="2014-10-29" version="1">MRYKPSESDAKSLALVGAGILASFTLAVFDIHTSLKSIGATVEIALAISIAYVVIMVAVMIAAILYGPGILTDWKQKRVRRKRLQGTLMIGILSDIPWNDYTRPYFASGFRPEDWEKIIYSVANDIHLKFEIQQISVDKDFEPFIAILNPYGGAYPEADLGESATLKKIKNYVANGGLFVNISDVPTYYVYGLTLKKITDNTPALYDTISSGKKVNIVEYRPFSNTPLIKGLALRIVTFDSGTQCNVELASDNGFSQFTKCSMTYRRALVIDSNVESCIEPLSVVVYDNSLRIQHGSQNYDISPIFYVNFEEGHFLVSLAYLDDGFHTSDDSIALADTLAKSMLDTVVATAKGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSR1</accession>
    <name>A0A075MSR1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative small metal-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02133</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700810.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSR1"/>
    <dbReference type="GeneID" id="41597861"/>
    <dbReference type="KEGG" id="nev:NTE_02133"/>
    <dbReference type="eggNOG" id="arCOG05278">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_200908_1_0_2"/>
    <dbReference type="OrthoDB" id="9023at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009409">
        <property type="entry name" value="DUF1059"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06348">
        <property type="entry name" value="DUF1059"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="56" mass="6415" checksum="1540B95EFFBECE89" modified="2014-10-29" version="1">MEMKCRDVGFNCDFVAKGNSEQEIMQQAAAHAQRDHGMKPEEITEDLQNKIRANIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSR8</accession>
    <name>A0A075MSR8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WYL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02139</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSR8"/>
    <dbReference type="KEGG" id="nev:NTE_02139"/>
    <dbReference type="eggNOG" id="arCOG08243">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_152989_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="111" mass="12570" checksum="3775926686C773CF" modified="2014-10-29" version="1">MAYVYHSIDEIIRAAIVSKNIIEFSYHNHDRIAEPHVYGIHNGRKQLLVYQIGGQSSSGNIPGWRRVNVDEMTSARITTQTFAGPRHYPSGQHGSFDEILAVVTYRDEIAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSZ0</accession>
    <name>A0A075MSZ0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00372</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699426.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSZ0"/>
    <dbReference type="GeneID" id="41596261"/>
    <dbReference type="KEGG" id="nev:NTE_00372"/>
    <dbReference type="HOGENOM" id="CLU_2079308_0_0_2"/>
    <dbReference type="OrthoDB" id="378758at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="117" mass="13413" checksum="8F99BE6CB5AFC978" modified="2014-10-29" version="1">MHRVVMMYYYAREEDEDIAATSGSSIRLVQDFAIVCLVCRHRFGNRRAVAHPTNAKMHKLICPSCIEDKALRRLYRDPEYKAAIIAMWDREKKKKEQLQAIALPSAPRHAATATIIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSZ8</accession>
    <name>A0A075MSZ8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glutamate--tRNA ligase</fullName>
            <ecNumber evidence="10">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Glutamyl-tRNA synthetase</fullName>
            <shortName evidence="10">GluRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">gltX</name>
        <name evidence="15" type="ORF">NTE_02266</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>tRNA(Glu) + L-glutamate + ATP = L-glutamyl-tRNA(Glu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="10"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSZ8"/>
    <dbReference type="STRING" id="1459636.NTE_02266"/>
    <dbReference type="KEGG" id="nev:NTE_02266"/>
    <dbReference type="eggNOG" id="arCOG04302">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001882_1_2_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043604">
        <property type="term" value="P:amide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="entry name" value="Ribosomal Protein L25, Chain P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02076">
        <property type="entry name" value="Glu_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050132">
        <property type="entry name" value="Gln/Glu-tRNA_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004526">
        <property type="entry name" value="Glu-tRNA-synth_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_bL25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_bL25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049437">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00463">
        <property type="entry name" value="gltX_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003169">
        <property type="entry name" value="PRK04156.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097:SF5">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097">
        <property type="entry name" value="GLUTAMINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20974">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="Ribosomal protein L25-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="12">
        <location>
            <begin position="117"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding" evidence="13">
        <location>
            <begin position="424"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA synthetases class I (E and Q) anti-codon binding" evidence="14">
        <location>
            <begin position="522"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="10">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF20974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AIF84320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="594" mass="66033" checksum="0044DCEA39FFA5EC" modified="2014-10-29" version="1">MPQILLSAGVCRSVPLDSEIEKLARTLALKNALEHGGKAAFDAVISKFIGSRPDKRAEIKSLIPEIKAVVQAVNAMPAAEQKALLEQLAPGELEAKKTHAESGPRLPPLEGAVMGSVVTRFPPEPNGYPHIGHAKAAIIDEEYARMYQGKLVLRFDDTNPLKEKLEYYGAIAEGLKWLGVKPDIVKNTSDDISKIHELGKKLVEAGGAYVCTCSQDKIHDLRAKGLPCECRLLDHSTALDRMGRMFDGSYEQNQAIIRFKGDMADQNTAMRDPTLFRIIEGAHPLLGNRVRVWPTYDFAAPIEDSLDGVTHAMRTKEYELRNALYYAILDRLAMRTPVMIEFSRLEFEGIPVSKRKIRPLIDNGTISSWDDPRLPTLSAFRRRGFVPEAIRKFVLSLGITLAETKPPFESLEAYNRKVIDPTSMRLFFVRDPVEVQIEGAAPMEVTLKNHPTDASLGSRKVRVSDRVYIAGEDAANLKAGDEVRLIELYNIRIKQIIKQEGGKVASIVAEVGGDEIRQSMPKIQWIAKNDIVEFKVMIPKELYIGEEYNTKSLEIAKGGAESFAAALAPDTCVQFVRFGFCRIDGNNTAILTHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTA6</accession>
    <name>A0A075MTA6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, AsnC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01974</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_075053954.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTA6"/>
    <dbReference type="STRING" id="1459636.NTE_01974"/>
    <dbReference type="GeneID" id="41597722"/>
    <dbReference type="KEGG" id="nev:NTE_01974"/>
    <dbReference type="eggNOG" id="arCOG01117">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_170329_2_0_2"/>
    <dbReference type="OrthoDB" id="8136at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription regulator AsnC/Lrp ligand binding" evidence="1">
        <location>
            <begin position="6"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="79" mass="8463" checksum="BA153847A540EE3E" modified="2014-10-29" version="1">MAEAYILINCELGSEDNVIKELKAISGVSEVKGVFGVYDIIARVNASNDEDLKKAVGKIRGHHGIKSSLTMMVIEGQGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTA7</accession>
    <name>A0A075MTA7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase</fullName>
            <ecNumber evidence="9">4.1.3.44</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">tRNA wyosine derivatives biosynthesis protein Taw1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">taw1</name>
        <name evidence="11" type="ORF">NTE_02755</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:36347"/>
            <dbReference type="Rhea" id="RHEA-COMP:10164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10165"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64315"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="EC" id="4.1.3.44"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TYW1 family.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.44" evidence="9"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701309.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTA7"/>
    <dbReference type="STRING" id="1459636.NTE_02755"/>
    <dbReference type="GeneID" id="41598444"/>
    <dbReference type="KEGG" id="nev:NTE_02755"/>
    <dbReference type="eggNOG" id="arCOG04174">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007952_3_0_2"/>
    <dbReference type="OrthoDB" id="68499at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102521">
        <property type="term" value="F:tRNA-4-demethylwyosine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01921">
        <property type="entry name" value="TYW1_archaea"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013917">
        <property type="entry name" value="tRNA_wybutosine-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034556">
        <property type="entry name" value="tRNA_wybutosine-synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023993">
        <property type="entry name" value="TYW1_archaea"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03972">
        <property type="entry name" value="rSAM_TYW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13930">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT TRNA 4-DEMETHYLWYOSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13930:SF0">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT TRNA 4-DEMETHYLWYOSINE SYNTHASE TYW1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08608">
        <property type="entry name" value="Wyosine_form"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00284">
        <property type="entry name" value="tRNA_wybutosine-synthesizing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01071">
        <property type="entry name" value="tRNA_wybutosine-synthesizing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0408">Iron</keyword>
    <keyword evidence="6 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 9" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Radical SAM core" evidence="10">
        <location>
            <begin position="65"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIF84796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="345" mass="40214" checksum="DAE80DD7E7AB44AB" modified="2014-10-29" version="1">MSCSDEYFSHSTTGEDNNLIQITPRVKEKLKKAKYGVYNHSAVELCHWTKKSFANEGSCYKHKFYGISTHQCMEMTPTAMNCENRCVYCWRPAEFYDTLEMPEQMVDEPEVIVQNLMAERKKLINGFYGNSKNDETKLDESLLPAHYAISLSGEPTMYPKLPQLIKYLKTLKATKSIFLVTNGQEPDMLRRLESEDALPTQIYLSTNASNRKMFLQVNRPRHKGAWERWQDSLHFLSTVDTRTVLRMTIIRGYNDGSDDIKDFAKVMSEGDPHFIEIKSYMHVGMSTQRLERDNMLGMEEVRGYANKLCEKMPAFSVMDESEISRIVVLQNKKRYVDRWIKSYFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTC6</accession>
    <name>A0A075MTC6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cytidylate kinase</fullName>
            <ecNumber evidence="1">2.7.4.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02791</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.4.14" evidence="1"/>
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        <property type="protein sequence ID" value="AIF84831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701339.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
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        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="196" mass="22046" checksum="666D7D17DD51E813" modified="2014-10-29" version="1">MAAAKKPSIVISGWPAVGKTTIAGALAKEFGLTMYNGGDILKMLAREKGYSTDTAKSDWWDTPEAKMFMQERKRDPSFDKRVDKKLEEILKSESAVITSYTLPWLVNDSAIIKFWLKGSSRSRAKRMANRDGIAVAEAEKIVNLRDNENIKIYKNLYGFTFGEDLSVFDYALNTDLLSLDALIEVAKLIVRRQVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTD6</accession>
    <name>A0A075MTD6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00488</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTD6"/>
    <dbReference type="STRING" id="1459636.NTE_00488"/>
    <dbReference type="GeneID" id="41596361"/>
    <dbReference type="KEGG" id="nev:NTE_00488"/>
    <dbReference type="HOGENOM" id="CLU_168334_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="119" mass="12580" checksum="76D884596A79C716" modified="2014-10-29" version="1">MPGYLFHVGGNAMCAHSAQVNHSSTNTRVKVSSQQVAIQQVPIKPGEYTVTGCGFQVPTPAGSKPQPCVSVTWTNLASRVKVMGQPVVLQDSTGQCWSGEQILQGAPTITTTQTRVKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTH9</accession>
    <name>A0A075MTH9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02883</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385561.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTH9"/>
    <dbReference type="STRING" id="1459636.NTE_02883"/>
    <dbReference type="GeneID" id="43502663"/>
    <dbReference type="KEGG" id="nev:NTE_02883"/>
    <dbReference type="HOGENOM" id="CLU_200903_0_0_2"/>
    <dbReference type="OrthoDB" id="372416at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="50" mass="6030" checksum="8FB79DAB9AC07445" modified="2014-10-29" version="1">MNAFDKSRISITAWCEDCECVFDNNWEVEAHRQDKGHRVRVTEFWVTGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTQ7</accession>
    <name>A0A075MTQ7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02971</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701480.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTQ7"/>
    <dbReference type="STRING" id="1459636.NTE_02971"/>
    <dbReference type="GeneID" id="41598642"/>
    <dbReference type="KEGG" id="nev:NTE_02971"/>
    <dbReference type="eggNOG" id="arCOG05900">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_968388_0_0_2"/>
    <dbReference type="OrthoDB" id="11833at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="287" mass="31417" checksum="990D979DAA33867A" modified="2014-10-29" version="1">MEGGDSDEIERKLQGRTLQVYLYLLKKGEPGGIREIQRDLGLSSPSVADYQVEKLVGMGLAAKDGYGRVHVTRKVKVRALESYVNFGRFSVPRLAFYASVFSAVAVLYVMFNLSSWSVYGVAVPLAAAGVLWLEAWRMWRFSLLERADRAESRRIKNAKGVLPLIVPGMVALAVFATGGAFLFQYVQELPSVQVVQNYITPDAGAAQQQATTIEESITLSKEKVAAAGQSAFAASSLAPSILPLAGATVIGFLGYLLVKYRCEGRVRMPEQVLHDASGTQDYPERFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTT1</accession>
    <name>A0A075MTT1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase SSV1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTT1"/>
    <dbReference type="STRING" id="1459636.NTE_02117"/>
    <dbReference type="KEGG" id="nev:NTE_02117"/>
    <dbReference type="eggNOG" id="arCOG01247">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1010487_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031857">
        <property type="entry name" value="Integrase_SSV1_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16795">
        <property type="entry name" value="Phage_integr_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase SSV1 C-terminal" evidence="1">
        <location>
            <begin position="96"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="268" mass="31320" checksum="3EAF27067C1F2346" modified="2014-10-29" version="1">MRLDGFDDYLRKALTSDKDVTYILAAAKKYQYVLTTGEAGKLLTVSADVRRQSMRALSHLARYNGVYQQWRMIIQQHGLRWRKTEDKFDFFEKESITEMIEYIKQTIKILPKDQANTFILATVLGLRADEVCKAAGLLKQGAQDYYDEDKGILEHYKFKELFIRRTKKAYISLVDTEMLELARQSCDSYQAIRSYLKRRDHPMQLNYGRKIFGTWLRQNGIESEFVDLLQGRTPKSVFARHYYRPDFAVNAAKVRKLVDELQEKVGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTY5</accession>
    <name>A0A075MTY5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">CRISPR-associated exonuclease Cas4</fullName>
            <ecNumber evidence="3 13">3.1.12.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">NTE_02569</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="13">Mg(2+) or Mn(2+) required for ssDNA cleavage activity.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>iron-sulfur cluster</name>
            <dbReference type="ChEBI" id="CHEBI:30408"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the CRISPR-associated exonuclease Cas4 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.12.1" evidence="3 13"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701153.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTY5"/>
    <dbReference type="STRING" id="1459636.NTE_02569"/>
    <dbReference type="GeneID" id="41598264"/>
    <dbReference type="KEGG" id="nev:NTE_02569"/>
    <dbReference type="eggNOG" id="arCOG00786">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102055_2_0_2"/>
    <dbReference type="OrthoDB" id="26676at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051827">
        <property type="entry name" value="Cas4_exonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013343">
        <property type="entry name" value="CRISPR-assoc_prot_Cas4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022765">
        <property type="entry name" value="Dna2/Cas4_DUF83"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00372">
        <property type="entry name" value="cas4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36531">
        <property type="entry name" value="CRISPR-ASSOCIATED EXONUCLEASE CAS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36531:SF6">
        <property type="entry name" value="DNA REPLICATION ATP-DEPENDENT HELICASE_NUCLEASE DNA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01930">
        <property type="entry name" value="Cas_Cas4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="8 13 15" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 13" id="KW-0408">Iron</keyword>
    <keyword evidence="10 13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="12 13" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 13" id="KW-0540">Nuclease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF83" evidence="14">
        <location>
            <begin position="7"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AIF84613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="197" mass="22486" checksum="F068CEC618EF8232" modified="2014-10-29" version="1">MKDLITVTDVVENAFCPKFTYYSLVLGLRQYEEKRGTVMAGRTLHTRSEKLNPTYVPKLARGKKLVAMQLYSTRLGLSGKIDEAYESSREIILVERKYTDFTVITDSLKAQIGLLSILLEENRNKPVTRVFVIFQKSKRVVREIRLTSELKNFALQKLESVKQIITSGISPNAQYGSKCLDCTYRKVCPTGSLYMNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTZ3</accession>
    <name>A0A075MTZ3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">2,3-di-O-geranylgeranylglyceryl phosphate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NTE_02579</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701161.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTZ3"/>
    <dbReference type="STRING" id="1459636.NTE_02579"/>
    <dbReference type="GeneID" id="41598273"/>
    <dbReference type="KEGG" id="nev:NTE_02579"/>
    <dbReference type="eggNOG" id="arCOG00570">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024648_0_1_2"/>
    <dbReference type="OrthoDB" id="6062at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011777">
        <property type="entry name" value="Geranylgeranyl_Rdtase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050407">
        <property type="entry name" value="Geranylgeranyl_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054715">
        <property type="entry name" value="GGR_cat"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02032">
        <property type="entry name" value="GG-red-SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42685:SF18">
        <property type="entry name" value="DIGERANYLGERANYLGLYCEROPHOSPHOLIPID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42685">
        <property type="entry name" value="GERANYLGERANYL DIPHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12831">
        <property type="entry name" value="FAD_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22578">
        <property type="entry name" value="GGR_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Digeranylgeranylglycerophospholipid reductase catalytic" evidence="8">
        <location>
            <begin position="174"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF84623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="399" mass="42952" checksum="D1B862BA1BF1C56B" modified="2014-10-29" version="1">MAGKYDIAVVGGGPAGLSAAWAAAKAGASVILFEKDEAIAHSVRTSGVSWIDSMDALGIPSRLYNPISSYQFVSPSNEVTIAGSNPRSCVLDVRATYQHLTFMAAEAGARIMIKSNVINVVKEGDRIAGVKASTPAGDLEVACPLVIDASGFGTSAARRAGMAGEWKRYGVGAEYECYCDHADSALWTLMVGQQYSEAGYAWVFPLSKNRVRIGVGIGRPESQADPLDKLNAILEKRLKPLDRLGKIQPVELHYGFIPNEGTRASTVADGLLMVGDSAGQANPLVLEGIRYAIEFGRLAGEVGARSLEGGASRESLLDYERAWKAKAASKIASALKVQSRWIGLSDEEWDREIEILRDMSADEFIDFVKAEFTAGKMIKLALHHPRLAARQLFNMVLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MU04</accession>
    <name>A0A075MU04_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00654</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MU04"/>
    <dbReference type="STRING" id="1459636.NTE_00654"/>
    <dbReference type="KEGG" id="nev:NTE_00654"/>
    <dbReference type="eggNOG" id="arCOG08773">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1243077_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="239" mass="26614" checksum="D49812BF9599AB6D" modified="2014-10-29" version="1">MTLILYALTIMRFDLRLKAPVYIPLAGLKDFGRLVCALERAPMPSFALTVGGKQVLAAQLDIMNGRPVIYFTEAEVGNSQYLAYRASNGVEEVMLADSVGNPTFVYSPILNVEKFPPALAKFGKVEKGTGYTVIKLKDMASLAKVAAYKTIYEEAPLPLFLAKQRGKTIIGTMMSVNENESLSYFYYVLLESEPAEPFLRYASQRPEQPAFCSSLDEHGYIYLKVIRLAADHPLVKTYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MU13</accession>
    <name>A0A075MU13_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00679</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699665.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MU13"/>
    <dbReference type="STRING" id="1459636.NTE_00679"/>
    <dbReference type="GeneID" id="41596536"/>
    <dbReference type="KEGG" id="nev:NTE_00679"/>
    <dbReference type="eggNOG" id="arCOG05330">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_194224_0_0_2"/>
    <dbReference type="OrthoDB" id="17596at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="68" mass="7643" checksum="B421B296ED0E310E" modified="2014-10-29" version="1">MGRVEKGVSCSVSGCENKAERSISGSKAAMAPDMGLNSSKHVYLCHEHYKEWKKASKEERENERARWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MU31</accession>
    <name>A0A075MU31_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00719</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699698.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MU31"/>
    <dbReference type="STRING" id="1459636.NTE_00719"/>
    <dbReference type="GeneID" id="41596571"/>
    <dbReference type="KEGG" id="nev:NTE_00719"/>
    <dbReference type="HOGENOM" id="CLU_2067696_0_0_2"/>
    <dbReference type="OrthoDB" id="384116at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="118" mass="13490" checksum="96EBD9A90E0B4FC4" modified="2014-10-29" version="1">MTTETAAFVSIFTGNITLILLVVALGIFGWLTARAKDIKGFQFQIFLFIVIWIVGEIADLMQEQMSGWIPLFSHYHEIGMYIHVLAMALLSAMLWTRFYLSRRSGKMIEDDSLHDGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MU96</accession>
    <name>A0A075MU96_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">2-(3-amino-3-carboxypropyl)histidine synthase</fullName>
            <ecNumber evidence="3 10">2.5.1.108</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NTE_02703</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine = 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36783"/>
            <dbReference type="Rhea" id="RHEA-COMP:9748"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="EC" id="2.5.1.108"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DPH1/DPH2 family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.108" evidence="3 10"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701262.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MU96"/>
    <dbReference type="STRING" id="1459636.NTE_02703"/>
    <dbReference type="GeneID" id="41598392"/>
    <dbReference type="KEGG" id="nev:NTE_02703"/>
    <dbReference type="eggNOG" id="arCOG04112">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037146_0_0_2"/>
    <dbReference type="OrthoDB" id="314at2157"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11850">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042264">
        <property type="entry name" value="DPH1/DPH2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035435">
        <property type="entry name" value="DPH1/DPH2_euk_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022428">
        <property type="entry name" value="Dph2_arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03682">
        <property type="entry name" value="arCOG04112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF1">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004967">
        <property type="entry name" value="DPH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 10" id="KW-0408">Iron</keyword>
    <keyword evidence="8 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIF84745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="333" mass="37798" checksum="3C111C9352B56FA6" modified="2014-10-29" version="1">MIKIDENRIFQIIEERKPRSIALNGAEALIPRLQDVADHVHEKFGIEAYVIGDPCWGSCDLNTHAADMLGADLLFNVGHTVAMETFGEKVVMINAYDDVSFDSVARKFAKDMQGRYKAISLVTDSQHLEEVDKARQVFEEFGYKVIIGRGKGQLRDAQVFGCEFYPAWNVQKQVDCYVFLGQSQFHSASVAMSTEKPTFMLDPYFEEYTQVNEFAQGLQKRAILSIYKAADAERIGIVIGLKEGQFAHVRALELKKEFERLGKKVQLIAITEITSDRMQIFKGIDAFVQVACPRIATDNHFTKPMLSVPQALALIKLLKKEPIEDFLRIQHWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUC4</accession>
    <name>A0A075MUC4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase</fullName>
            <shortName evidence="5">HPPK</shortName>
            <ecNumber evidence="5">2.7.6.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">6-hydroxymethyl-7,8-dihydropterin diphosphokinase</fullName>
            <shortName evidence="5">6-HMPDK</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">7,8-dihydro-6-hydroxymethylpterin diphosphokinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase</fullName>
            <shortName evidence="5">PPPK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">mptE</name>
        <name evidence="7" type="ORF">NTE_03217</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the transfer of diphosphate from ATP to 6-hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>6-hydroxymethyl-7,8-dihydropterin + ATP = (7,8-dihydropterin-6-yl)methyl diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11412"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:44841"/>
            <dbReference type="ChEBI" id="CHEBI:72950"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal 6-HMPDK family.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.3" evidence="5"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUC4"/>
    <dbReference type="STRING" id="1459636.NTE_03217"/>
    <dbReference type="KEGG" id="nev:NTE_03217"/>
    <dbReference type="eggNOG" id="arCOG04303">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093043_0_0_2"/>
    <dbReference type="OrthoDB" id="34207at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003848">
        <property type="term" value="F:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004788">
        <property type="term" value="F:thiamine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10240">
        <property type="entry name" value="Thiamin pyrophosphokinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02131">
        <property type="entry name" value="HMPDK_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027510">
        <property type="entry name" value="HMPDK_MptE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002826">
        <property type="entry name" value="MptE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036759">
        <property type="entry name" value="TPK_catalytic_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39648">
        <property type="entry name" value="6-HYDROXYMETHYL-7,8-DIHYDROPTERIN PYROPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39648:SF1">
        <property type="entry name" value="6-HYDROXYMETHYL-7,8-DIHYDROPTERIN PYROPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01973">
        <property type="entry name" value="MptE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63999">
        <property type="entry name" value="Thiamin pyrophosphokinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="6-hydroxymethylpterin diphosphokinase MptE-like" evidence="6">
        <location>
            <begin position="67"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF85246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="259" mass="28728" checksum="503B5E9A940A96E5" modified="2014-10-29" version="1">MPLLTLRRSWLEKDININVCATHSVKFVDWFPYYQGIRAEFGYSTEKDQEAARMLSGMIKRKALEPKVLQKKIAGKSVLVLGAGPSLAENIKIIKKNKAFVKIAADGAVQELLENKIKPDIVVTDLDGDSALLQKAAKSGAVMVVHAHGDNTDMLKKLVPKFKKVLGTTQVMPVENVYNFGGFTDGDRCVFMAEEFGAKKIVMMGMDFGGTSAYKDVKDPELKKRKMQAGKRLLETLAKQSRSQLFHASKKPVKGFSPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUC8</accession>
    <name>A0A075MUC8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF541 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02268</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700917.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUC8"/>
    <dbReference type="STRING" id="1459636.NTE_02268"/>
    <dbReference type="GeneID" id="41597983"/>
    <dbReference type="KEGG" id="nev:NTE_02268"/>
    <dbReference type="eggNOG" id="arCOG04715">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_678999_0_0_2"/>
    <dbReference type="OrthoDB" id="10890at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.170">
        <property type="entry name" value="Protein of unknown function (DUF541), domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2970">
        <property type="entry name" value="Protein of unknown function (DUF541), domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052022">
        <property type="entry name" value="26kDa_periplasmic_antigen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007497">
        <property type="entry name" value="SIMPL/DUF541"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34387">
        <property type="entry name" value="SLR1258 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34387:SF2">
        <property type="entry name" value="SLR1258 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04402">
        <property type="entry name" value="SIMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="405" mass="42897" checksum="B4FA72E5A878553B" modified="2014-10-29" version="1">MNKFTRKKLAATAAALSLAAAITSMSFFVAGSPLLLKSELQKAYSQDYAALPSSGKPATIKVTGEASTTIKPDQATMIINTQTSPGDLSSILSKHQDRTQQIAQAVREATDEKTVIAFGQQYLNPFYTNTGAQASNNVTFNVYASVAVQTNIDHLPGLVNRLADAGFGFDSVYIDPVYSATILQKAESAASAGSTLVKVNDGAANNQTQTAKERNPISIGVSLGTKPDVLSKAIAEYEQKYRSLLGVLKEAGISEDQVRQNNLNIYPFFYGPNQNAGYSMSTQIIVKTDPANIGKVTAALQKTGGANVENVFLSASDAAIDQARKELGKQAFDNARSRAEEMAQSLGLQVNGIVSIDAATDSPAPYGGFIPYRGVHVTQSYIPNTNGEVSKSVTVEFELGKAGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUE6</accession>
    <name>A0A075MUE6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TIGR00268 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02779</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701329.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUE6"/>
    <dbReference type="STRING" id="1459636.NTE_02779"/>
    <dbReference type="GeneID" id="41598468"/>
    <dbReference type="KEGG" id="nev:NTE_02779"/>
    <dbReference type="eggNOG" id="arCOG00043">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061181_2_0_2"/>
    <dbReference type="OrthoDB" id="61764at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01990">
        <property type="entry name" value="LarE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005232">
        <property type="entry name" value="LarE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052188">
        <property type="entry name" value="Ni-pincer_cofactor_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018317">
        <property type="entry name" value="QueC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00268">
        <property type="entry name" value="ATP-dependent sacrificial sulfur transferase LarE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43169">
        <property type="entry name" value="EXSB FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43169:SF2">
        <property type="entry name" value="NAD_GMP SYNTHASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06508">
        <property type="entry name" value="QueC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006661">
        <property type="entry name" value="PP-lp_UCP006661"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="267" mass="29306" checksum="1FC04CDE030C5153" modified="2014-10-29" version="1">MTATSLDRLVSWFPAGSRVIVALSGGVDSAVVALAAKKALGDNAIAITADYKTLADEELATARKVAQEIGIRHLVIEYDELENPEFVKNDGMRCYHCRTELGQHLAGEAKKAGAQLVVDGTNIDDLSDYRPGIRALRENGVKSPMVELGIGKAEIRRMAKEFGLSVYDKPSNACLASRIPVGMEVTYEKLRKIESSEIIVKSIFGVRQVRVRDHGEIARIEVGRDELGRMFDPEKLDLLDKKLKELGFRFVTIDASGYKSGKLAVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUJ5</accession>
    <name>A0A075MUJ5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02852</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUJ5"/>
    <dbReference type="STRING" id="1459636.NTE_02852"/>
    <dbReference type="KEGG" id="nev:NTE_02852"/>
    <dbReference type="eggNOG" id="arCOG08795">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1529153_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="175" mass="18515" checksum="FB68AC992ED14BAB" modified="2014-10-29" version="1">MSSVLVHFAAAALLLALPFFLQPPPAFAQAAGNANPVMLESTSDQGTFLVKIEWTPADIGTDNTFKIRFIEPETGRELEDVAYDFIIVSSASGQEVVHRHSQTSEAAAAASTQTVEFSAQGPYTIKIANIDGLGEGANFDVTVTPEFAPAMIILAAAAGIALVSTIFRARFQKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUR8</accession>
    <name>A0A075MUR8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Arabinose efflux permease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NTE_00974</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699894.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUR8"/>
    <dbReference type="STRING" id="1459636.NTE_00974"/>
    <dbReference type="GeneID" id="41596804"/>
    <dbReference type="KEGG" id="nev:NTE_00974"/>
    <dbReference type="eggNOG" id="arCOG00130">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_10_11_2"/>
    <dbReference type="OrthoDB" id="117970at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17330">
        <property type="entry name" value="MFS_SLC46_TetA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF15">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="367"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="15"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF83049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="413" mass="43092" checksum="82B3630E7EC1D290" modified="2014-10-29" version="1">MRRIAATSRTSSSSVFPVLFVTVFLDFLGFAMVLPYLYFYASSLGASPVVYGLLLTSYSVAQFAFTPVWGALSDRLGRRKIMLVCLVGSGAAFVLFGIASNIVLLFLARIAAGAMGATVPVAMAYASDITTAQNRMAQMGRLGAAFGMGLILGPAVGGTLSSAFGYAVPAFLAAALAFSNLALGYFKMPESRGARTKDSFLQSFRQIAKSPGIKLLLAAYFITMLGFYVMEGTSTPWLQKVFDYGPFQVGLLFLYIGGVVSAVQGVAVPKLSRMYAPQTLFVAGVASLAAGLALLGFAQDLATLIVSSTFVPLGMGLTTASITTLISLRTAADKQGATLGIGQSVAGISQIIGPSFGAAVFSQGIAVGAIGLPFMVAAAMTVPAVMMGIWFATRQARIAPRQEEEGEGNDHVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUY4</accession>
    <name>A0A075MUY4_9ARCH</name>
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        <submittedName>
            <fullName evidence="4">Site-specific recombinase XerD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_02995</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUY4"/>
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    <dbReference type="KEGG" id="nev:NTE_02995"/>
    <dbReference type="eggNOG" id="arCOG01245">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057056_0_0_2"/>
    <dbReference type="OrthoDB" id="12201at2157"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="CDD" id="cd00397">
        <property type="entry name" value="DNA_BRE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Intergrase catalytic core"/>
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    </dbReference>
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        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
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        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
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        <location>
            <begin position="117"/>
            <end position="327"/>
        </location>
    </feature>
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        <location>
            <begin position="337"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF85030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="376" mass="43986" checksum="A6EC104CB95689AD" modified="2014-10-29" version="1">MSNKRTFPEYEDATAWKNFVNTIKSKETAAHYKLNLVRFLTFAKVNCSLDEFVNLDRKRLEKLIVDFIMHRQDEEKVRAQTVAVELSCIKHFFVYNDRPDINWKIIRGYLHEAIKAVKDKAYTTEEIQKMLTYADLRTKCVILLMASSGMRVGAITNLRMKDLHEIPQYGIYAITPYANTRDEYVTYCSPECKAAIDAYLHFRKLRGENINPNSPLIRERFDFNNPAKTHDARPIHRDTLAHLTNACAISAGLRVKTDKQNRDRKDNMLNHAFRKFFFKACGRAQINPIVRELLMGHKVGNQQTGVTRLMMVYDATEENELLREYLRVIEHVTITDENRAKMQLKEKEERTKQLEVEFQQFKTAMSQLHEQGLITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUZ7</accession>
    <name>A0A075MUZ7_9ARCH</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUZ7"/>
    <dbReference type="STRING" id="1459636.NTE_03015"/>
    <dbReference type="KEGG" id="nev:NTE_03015"/>
    <dbReference type="eggNOG" id="arCOG08662">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_182705_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="97" mass="11107" checksum="71B9D4E3E90CB4F6" modified="2014-10-29" version="1">MDCTTLTIPASLACPKSHIDMSCRGLCKKHPHYIPVKKIEYAKGMKVCITCDRAIFVNMEETKCPCCNKNLRTRPQYHGDKGRLAREATMHRLFTSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MV45</accession>
    <name>A0A075MV45_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03086</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MV45"/>
    <dbReference type="KEGG" id="nev:NTE_03086"/>
    <dbReference type="HOGENOM" id="CLU_1631560_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="162" mass="18861" checksum="4B9B4A16CE556DAC" modified="2014-10-29" version="1">MYILFPDLDFDVKCRCMVHNVLALLIARICNKKRAYTPNKATAPSRSEVCVSLLLMSWGRLVQMCIWVYADGSKKLLNARKYDDDDSNNRDNLMQGSWALGMKYHENADEEDELYEELQKRGINVGEFRKMGLSIEELRDFVYRLDRLLERHPDGSDDEKCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MV56</accession>
    <name>A0A075MV56_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9 10">DNA repair and recombination protein RadA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">NTE_01091</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 10">Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the eukaryotic RecA-like protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MV56"/>
    <dbReference type="STRING" id="1459636.NTE_01091"/>
    <dbReference type="KEGG" id="nev:NTE_01091"/>
    <dbReference type="eggNOG" id="arCOG00415">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041732_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002052">
        <property type="entry name" value="DNA repair protein RAD51 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011938">
        <property type="entry name" value="DNA_recomb/repair_RadA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016467">
        <property type="entry name" value="DNA_recomb/repair_RecA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010995">
        <property type="entry name" value="DNA_repair_Rad51/TF_NusA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003301">
        <property type="entry name" value="PRK04301.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02236">
        <property type="entry name" value="recomb_radA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942:SF30">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN DMC1_LIM15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942">
        <property type="entry name" value="RECA/RAD51/RADA DNA STRAND-PAIRING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005856">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47794">
        <property type="entry name" value="Rad51 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 10" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="11">
        <location>
            <begin position="112"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="RecA family profile 2" evidence="12">
        <location>
            <begin position="288"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="NCBIfam" id="TIGR02236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIF83164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="350" mass="38347" checksum="96649BA0DEF0375F" modified="2014-10-29" version="1">MLRSKRFLCARYQLVAGAQEKSALGEDESSKLALGSIEDIGPATEKRLKEAGFRSIKDLLVRGPVDVAEATGMEMDEAVEMCNKARIALEELGIIDRSFVTATSLYEKRMLGGQRISTGAKNFDDLLGGGVETKAVTEVYGEFGTGKTQLCHTLCVMVQQPKTAGGLSGKAIYIDTENTFRPERIVTIARARGVNPDRALEGIVVAKAYNSAHQELIIEETGPVIEEQGIKLVIVDSAVAHYRAEFLGRATLSERQQRLNKFMHILVRMAETYEVAVVVTNQIQSSPDAYFGDAARPTGGNVVAHTSTYRIYLKRSSGKNRIARMVDSPYHAEREVLFTLADKGIADVEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MV68</accession>
    <name>A0A075MV68_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01101</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385124.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MV68"/>
    <dbReference type="GeneID" id="43502594"/>
    <dbReference type="KEGG" id="nev:NTE_01101"/>
    <dbReference type="HOGENOM" id="CLU_3194330_0_0_2"/>
    <dbReference type="OrthoDB" id="372322at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="45" mass="5252" checksum="41BEF964BBE15A3E" modified="2014-10-29" version="1">MDMSATCGACGKKTQDYPVFCYMCNDYFCSEACHMTKHARPWQKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVC9</accession>
    <name>A0A075MVC9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">CRISPR-associated helicase, Cas3 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NTE_02573</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the central section; belongs to the CRISPR-associated helicase Cas3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVC9"/>
    <dbReference type="STRING" id="1459636.NTE_02573"/>
    <dbReference type="KEGG" id="nev:NTE_02573"/>
    <dbReference type="eggNOG" id="arCOG01445">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010123_1_1_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140097">
        <property type="term" value="F:catalytic activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09641">
        <property type="entry name" value="Cas3''_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054712">
        <property type="entry name" value="Cas3-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006483">
        <property type="entry name" value="CRISPR-assoc_Cas3_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038257">
        <property type="entry name" value="CRISPR-assoc_Cas3_HD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006474">
        <property type="entry name" value="Helicase_Cas3_CRISPR-ass_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01587">
        <property type="entry name" value="cas3_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01596">
        <property type="entry name" value="cas3_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF16">
        <property type="entry name" value="CRISPR-ASSOCIATED NUCLEASE_HELICASE CAS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22590">
        <property type="entry name" value="Cas3-like_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18019">
        <property type="entry name" value="Cas3_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51643">
        <property type="entry name" value="HD_CAS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD Cas3-type" evidence="11">
        <location>
            <begin position="13"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="455"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIF84617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="731" mass="83971" checksum="DF8134F04AEDDE72" modified="2014-10-29" version="1">MVEKLSVSTDTFLSHPGKPLDEHLIRVATSAEGIVRKTRFESCKLAYYAGLLHDIGKLNPFYQELFQAGDEKRRLIEDDLESKYERQHALFSAWAAEKLLADELDSNQLQLVLCVIAAHHSHLSNEIQNEDQTDRMKRTKQGLLENLAKFKGAMANTQHFSTLDWDQCLSKFARPMSFENKLQSLSGDAVRDFIEACMIFSALLQADRGSFSERQDIKYDLRMSTNRLVNTTSGLSKLRTEFQQWFASTHDFAAPVSVLNAPTGMGKTKVFLDLINEYSNIHGIERVMYFSPLLALTEDFESKIKDVLDQQALDEILVYNHLFAGSLASKLSESRTLESLGYNFENESFHSKFVISTTQRLLMILYFNSVSDKMKLASLRNALLIVDEIQVVPKFLLPNFIKMLQKICQEMNSKTLLVSATIPYELSNNVPITRVPQTLSETYHRLTLKNIRFMTRFQPPVRIDRKILVMLNTRKKAKEVFYEMSQNGHQSLYVTSGIRKKTRSDIIQKIKEKGKNVIVVSTQVLEAGVDVSFAEVYREVAPLDNVVQVMGRLNREGEATNPMLFIFQKDSDYLPYSELEYQESLKILKKVKNSKELYDKLDSYYERVSVKNMQNADRIEELDRLIRDMDFEDVSRFVNNHVFADEGHSMIVPEAEQDLQKISEALKSTQRIDRRSFKSYSALTANISASSVKLVRDYLDQELLERGILIPKKGCLQDVYDVEVGLDKWIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVT6</accession>
    <name>A0A075MVT6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Proteasome subunit alpha 1</fullName>
            <ecNumber evidence="3">3.4.25.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_03336</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EC" id="3.4.25.1" evidence="3"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701781.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVT6"/>
    <dbReference type="STRING" id="1459636.NTE_03336"/>
    <dbReference type="GeneID" id="41598985"/>
    <dbReference type="KEGG" id="nev:NTE_03336"/>
    <dbReference type="eggNOG" id="arCOG00971">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035750_4_1_2"/>
    <dbReference type="OrthoDB" id="6330at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004175">
        <property type="term" value="F:endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 2 3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF85365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="221" mass="23626" checksum="6472EDF2069E2C85" modified="2014-10-29" version="1">MAEAGAGGFSNRYPSFYGPEGRLVLVDSALEAVNRGSTTIGIKTPSFALLASHIKPARPLMEPTEKVFPVDSHVGATGSGYIGDILQLIDELRLEAQKHRLSFESPIDIGSLTKHLGGYLHNYTIYAVRPQAASVIIAGADQTGVHMYQVDPSGTYFRGAGFAIGQSADSALDVIQREYSADMTVEQAVQLGNKAIEKALGERSVVETGVVTAKEGKFRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVU5</accession>
    <name>A0A075MVU5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Iron (Metal) dependent repressor, DtxR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NTE_03239</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DtxR/MntR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987049.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVU5"/>
    <dbReference type="STRING" id="1459636.NTE_03239"/>
    <dbReference type="GeneID" id="41598894"/>
    <dbReference type="KEGG" id="nev:NTE_03239"/>
    <dbReference type="eggNOG" id="arCOG02099">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069532_4_1_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050536">
        <property type="entry name" value="DtxR_MntR_Metal-Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001367">
        <property type="entry name" value="Fe_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036421">
        <property type="entry name" value="Fe_dep_repressor_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022687">
        <property type="entry name" value="HTH_DTXR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022689">
        <property type="entry name" value="Iron_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33238">
        <property type="entry name" value="IRON (METAL) DEPENDENT REPRESSOR, DTXR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33238:SF7">
        <property type="entry name" value="IRON-DEPENDENT TRANSCRIPTIONAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02742">
        <property type="entry name" value="Fe_dep_repr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01325">
        <property type="entry name" value="Fe_dep_repress"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00529">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47979">
        <property type="entry name" value="Iron-dependent repressor protein, dimerization domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50944">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH dtxR-type" evidence="5">
        <location>
            <begin position="19"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF85268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="152" mass="17468" checksum="897EDCD28F73D5D4" modified="2014-10-29" version="1">MTREEDSSEEKLYVGTAESEHVEMYLKAIWYIAEREEEVRVSSIAKLLNVRQPSVIQMLKKLAGLNLVKYTSQEVGITPEGERVGKQMIRNTRLLEVLMNDALKIEVDEEMVCGIEHHMKDIFTEALCTLLNHPRQCPHGHSIPRGRCCPYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVZ3</accession>
    <name>A0A075MVZ3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03284</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701741.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVZ3"/>
    <dbReference type="STRING" id="1459636.NTE_03284"/>
    <dbReference type="GeneID" id="41598938"/>
    <dbReference type="KEGG" id="nev:NTE_03284"/>
    <dbReference type="eggNOG" id="arCOG08701">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2505070_0_0_2"/>
    <dbReference type="OrthoDB" id="11999at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="89" mass="9262" checksum="01A074F8A7EA0B27" modified="2014-10-29" version="1">MSGGSSSGSDDSGKNPANIIGRVYAVSTLLAVIIAVPAVVVAVITHFVFQTDIVVTLAASLIALFISMGFGIRLAKRFVRAPQKEEKDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWI7</accession>
    <name>A0A075MWI7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oxygen-sensitive ribonucleoside-triphosphate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NTE_03465</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701890.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWI7"/>
    <dbReference type="GeneID" id="41599099"/>
    <dbReference type="KEGG" id="nev:NTE_03465"/>
    <dbReference type="HOGENOM" id="CLU_1870629_0_0_2"/>
    <dbReference type="OrthoDB" id="10922at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03477">
        <property type="entry name" value="ATP-cone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-cone" evidence="5">
        <location>
            <begin position="12"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="101"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF85493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="136" mass="15447" checksum="BBECD84A293232A6" modified="2014-10-29" version="1">MSFKKTTRSNRITVKKRSGRLEPFDSRKMARATSRAGVPYSIALEIAKRIKNSKSLSERSQVSSTTLRKMVAEELIKHNHDTVAKSYLGYKKIEGARKEKFARSLRHRSKVGKSIKTHTKQAVKDKDISGGRSTRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWU5</accession>
    <name>A0A075MWU5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01668</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700448.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWU5"/>
    <dbReference type="GeneID" id="41597443"/>
    <dbReference type="KEGG" id="nev:NTE_01668"/>
    <dbReference type="HOGENOM" id="CLU_2730140_0_0_2"/>
    <dbReference type="OrthoDB" id="385551at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="71" mass="8478" checksum="2612976F6DC4AA0D" modified="2014-10-29" version="1">MAENKQKRSLSEKRRSVLKTPRNPLLFFNFVRKLNELNPEPIDEELIDRDLEPQEALNELKKRHPDLAVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWV8</accession>
    <name>A0A075MWV8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Oligoendopeptidase, pepF/M3 family</fullName>
            <ecNumber evidence="9">3.4.24.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NTE_03103</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="9"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701586.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWV8"/>
    <dbReference type="STRING" id="1459636.NTE_03103"/>
    <dbReference type="GeneID" id="41598763"/>
    <dbReference type="KEGG" id="nev:NTE_03103"/>
    <dbReference type="eggNOG" id="arCOG04758">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021290_3_0_2"/>
    <dbReference type="OrthoDB" id="275607at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09610">
        <property type="entry name" value="M3B_PepF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.20">
        <property type="entry name" value="Oligoendopeptidase f, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.70">
        <property type="entry name" value="Oligopeptidase f, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013647">
        <property type="entry name" value="OligopepF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042088">
        <property type="entry name" value="OligoPept_F_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011977">
        <property type="entry name" value="Pept_M3B_clade3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02290">
        <property type="entry name" value="M3_fam_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804:SF5">
        <property type="entry name" value="OLIGOENDOPEPTIDASE F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08439">
        <property type="entry name" value="Peptidase_M3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Oligopeptidase F N-terminal" evidence="8">
        <location>
            <begin position="117"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M3A/M3B catalytic" evidence="7">
        <location>
            <begin position="208"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF85137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="603" mass="68777" checksum="4432250A2603D673" modified="2014-10-29" version="1">MNFATLKIGSWDLSGLVKDPAGAEFAQFLDSIEDKVKAFEGKRQSLRPDIPAPEFEGMVHDLEDIYEKLSIAGGYAHLRYYSNTASNEASALVTRMDKMSAEAGNRLLFFDLWFKKELDEGNAKRLIESMPAVYSNYLRHKRLLAKHSLSEPEERIINTLEVTGTGALVKIYDKMTSAFEFEMSLKRGRKKKTITKKFDNKEKLVSLVRSANPAEREAAYRALFATYRKNSGVLGEIYQNIVVEWRNEGISMRGYRTPISVRNIANNLDDETVGALLQACRKNNKVFQEYFREKARLLGVRKLRRYDLYAPLSTKRSGKKFAYGKAVASVLDTFGDFHPQVRALAERVFSEHHVDSEIRRAKRGGAFCHTVSPSTTPYVLLNFDGRTRDVSTLAHEFGHAIHSMLAEKLPITVSHAPLPLAETASVFAEMLLNERLMEKMSRQERQLLLAEQIDDMYATIMRQAYFTLFEVDAHRAIGEKNATIDQVTQIYTENLKEQFGDSVVVSPEFGWEWIYIPHFYHTPFYCYAYSFGNLLVLSLYQQYKVEGKPFVPKYLGILAAGGSRKPEELLKESGLDITREEFWQQGFDLVGEKIQQLKGLASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MX50</accession>
    <name>A0A075MX50_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Site-specific recombinase, DNA invertase Pin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NTE_01808</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the site-specific recombinase resolvase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700564.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MX50"/>
    <dbReference type="STRING" id="1459636.NTE_01808"/>
    <dbReference type="GeneID" id="41597573"/>
    <dbReference type="KEGG" id="nev:NTE_01808"/>
    <dbReference type="eggNOG" id="arCOG03162">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010686_8_2_2"/>
    <dbReference type="OrthoDB" id="24728at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00338">
        <property type="entry name" value="Ser_Recombinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="entry name" value="Resolvase, N-terminal catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006118">
        <property type="entry name" value="Recombinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006120">
        <property type="entry name" value="Resolvase_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050639">
        <property type="entry name" value="SSR_resolvase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30461">
        <property type="entry name" value="DNA-INVERTASE FROM LAMBDOID PROPHAGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30461:SF19">
        <property type="entry name" value="SITE-SPECIFIC RECOMBINASE RESOLVASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02796">
        <property type="entry name" value="HTH_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="Resolvase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00397">
        <property type="entry name" value="RECOMBINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51736">
        <property type="entry name" value="RECOMBINASES_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0229">DNA integration</keyword>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Resolvase/invertase-type recombinase catalytic" evidence="5">
        <location>
            <begin position="4"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF83869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="200" mass="22943" checksum="E54CC6F08EBB3DC7" modified="2014-10-29" version="1">MKKYAFAYLRVSTEEQTVQNQRLALEKWANDNNFQILDFFEDSAVSGRVPAAQRRGFRDLVEMVKTATVDAVLVYELSRVGRTFWDTLDAIKAIEQYAPLLSCSPRESFLQTTEPSVRKLMIGILTWVAEREREMLVQRTKDGMERARAAGRGIGRPQKVLDKDRLIAMLAENRSKARIARELGVSKATLYKELRQISKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MX94</accession>
    <name>A0A075MX94_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydropteroate synthase</fullName>
            <ecNumber evidence="2">2.5.1.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03213</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">SR1</strain>
        </source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="288" mass="30827" checksum="AED7E07D2CFA91E9" modified="2014-10-29" version="1">MAVKIGRVEVGGSKNHVKVMGIINASPESFFSGSVRTGFNEVAQTAREMQDAGAHVIDIGAMSTAPYLDTIIPAEEEVRRLKTAMEAAKSACSLPISVDTPRAEVAEAAVKLGADAINDVTGLQYDRRMAQVAARAGLPVIIGAYSRTPASGRVAGTVRALKESIAMAKKAGIRKEMIIVDPSIGFFRAEGRNPFFTKIADGDKMQWYARDLEVLSSLHRLAALAPVCVSVSRKSFIGHLLNLPKAEERMAPSIACEVVAAINGASLVRTHSVKETVQALTMLELLRR</sequence>
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        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
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                <person name="Drew J.C."/>
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                <person name="Daroub S.H."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">SR1</strain>
        </source>
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            <dbReference type="EMBL" id="AIF83944.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
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</entry>
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        <name evidence="2" type="ORF">NTE_03399</name>
    </gene>
    <organism evidence="2 3">
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        <lineage>
            <taxon>Archaea</taxon>
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            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
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            <taxon>Nitrososphaera</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="34"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="91" mass="10130" checksum="D853B192F6D04836" modified="2014-10-29" version="1">MPLSGVFHGKTNRERNIDSLCMGGIDLKRRIKIFRCPDCRKGFESLRGLNDHITKTGHNERQKIRAETKVTSRGLSVVFIACAAQASSIEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MY59</accession>
    <name>A0A075MY59_9ARCH</name>
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        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
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        <name evidence="10" type="ORF">NTE_02155</name>
    </gene>
    <organism evidence="10 11">
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        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SR1</strain>
        </source>
    </reference>
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        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
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        </reaction>
    </comment>
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    </dbReference>
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    </dbReference>
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    <dbReference type="STRING" id="1459636.NTE_02155"/>
    <dbReference type="GeneID" id="41597879"/>
    <dbReference type="KEGG" id="nev:NTE_02155"/>
    <dbReference type="eggNOG" id="arCOG02358">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031353_0_0_2"/>
    <dbReference type="OrthoDB" id="342253at2157"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sensor histidine kinase WalK"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
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        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
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        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050736">
        <property type="entry name" value="Sensor_HK_Regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43711:SF1">
        <property type="entry name" value="HISTIDINE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43711">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
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    </dbReference>
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        <property type="entry name" value="HIS_KIN"/>
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    </dbReference>
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    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
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            <end position="607"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIF84209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="607" mass="66268" checksum="641E34E885D5DD5B" modified="2014-10-29" version="1">MTLQGKRDSIFASARTGFAIIVAIIVMSYGLFFYLETSAEFQIRGIQFERSKDNQVVITEGIANRLESSVELATTKFRVMASEIEEIGDSAQLSARLDQIESLYVDRLHSGLAAMLDKDGAIVWLGGGGNNNGSGKSGYYGWNVGNNLSQYSWVQKTKDALAPVFTGEHAPGNNNIDLLVMTHPLVQHGQYRGQLVQFLPAGPVAQDVGQNLPEAQALSVLDLDGKFVLSSDESLLHQQFFSSEQGLNTVGGESEDLRNAVDAGLRGDTNPQRVLYRVDGEEMLTVGVPVTEGAAASNNAPVYYLLVTTPVSFFYKEINQVLVAQRLQAFSILAGTSVSVIILAVFVNRAASLDREVRRRTSELQASNTLITQQKKELEKANEDLKQLDRMKDEFLNIAAHELRTPITPILMAAEELEDELGKRSDVRMIARNAKKLQRLVQNVLDLARIENNTFKLAKEPANLGEVVYATVEDYRAQLEDKAGSAIVYDMTDVPMNLDKTRIMQVLSNLLGNAIKFTKQGTVTVSVTKDAAAGKVTVAVRDTGKGIDPEIMPRLFQKFATKSDSGTGLGLYISKSIVEAHGGTMWAENNADGAGGATFYFTLPLAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MYV9</accession>
    <name>A0A075MYV9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutamine--fructose-6-phosphate aminotransferase [isomerizing]</fullName>
            <ecNumber evidence="2">2.6.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NTE_02397</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:13237"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="2.6.1.16"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.6.1.16" evidence="2"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701022.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MYV9"/>
    <dbReference type="STRING" id="1459636.NTE_02397"/>
    <dbReference type="GeneID" id="41598109"/>
    <dbReference type="KEGG" id="nev:NTE_02397"/>
    <dbReference type="eggNOG" id="arCOG00057">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012520_7_0_2"/>
    <dbReference type="OrthoDB" id="8692at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006047">
        <property type="term" value="P:UDP-N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00714">
        <property type="entry name" value="GFAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000006">
        <property type="entry name" value="Glutamine--fructose-6-phosphate aminotransferase [isomerizing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005855">
        <property type="entry name" value="GFAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047084">
        <property type="entry name" value="GFAT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01135">
        <property type="entry name" value="glmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001484">
        <property type="entry name" value="PRK00331.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937">
        <property type="entry name" value="GLUCOSAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE, ISOMERIZING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="GLUTAMINE--FRUCTOSE-6-PHOSPHATE TRANSAMINASE (ISOMERIZING)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13522">
        <property type="entry name" value="GATase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 11" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="9">
        <location>
            <begin position="2"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="10">
        <location>
            <begin position="274"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="10">
        <location>
            <begin position="441"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00055466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIF84449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="588" mass="63373" checksum="6A9F220092488AD4" modified="2014-10-29" version="1">MCSILGYKGSKDAASLLVNGLKLMEYRGYDSVGIATLHDDKIDIAKGVGRVIEVSKNLFMENMQGTTGVGHTRWATHGGVTDINAHPHTSCDGKVAVVHNGIIENYKELKEELIAAGHVFKSQTDSEVIAHLFEGAKGDTRQAMLSVCSRLRGSYAFVAVFKDGTIAGARWEEPLIVGIADSEYFLSSDVLGFIKFTDRAMFLENGDIVVIDGKSLQLYDVDGKPVSRAVSPIAWELGAADKGIYAHHTLKEINEQGRTITGALAANQQKLGEFAHMISSAKHVYLTGSGTSSHAAMVGKQLFSKYAKIKSDVIISSEFQYALDMIDSGSVLIAISQSGESADVLQSVKNARQRGAKILSIVNVSTSSLARASDMFLDIGCGPEIGVAATKSFTAQLAVLYSIAGQLSQSSENKEIFLHSNKDIASAVDKALALYPAVAHVAEVLSTVNDIYLLGRFLHYPIALEGALKLKELAYVHAEGIAAGELKHGPLALMDKGTLVVLINPTDNTFMDTLSNAHEMKARGATIVGVSDQNNELYDYWIQLPKVQDVFYPLVEAIPLQILAYCMAVGKKVDPDYPRNLAKSVTVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MZD6</accession>
    <name>A0A075MZD6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MZD6"/>
    <dbReference type="KEGG" id="nev:NTE_02565"/>
    <dbReference type="HOGENOM" id="CLU_3282671_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="40" mass="4597" checksum="0A69C1CF5CA7B116" modified="2014-10-29" version="1">MKKIPKQSLSNLFLKLLGGMFGIPIILTKLLERKISQRIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MZW8</accession>
    <name>A0A075MZW8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">High-affinity Fe2+/Pb2+ permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NTE_02742</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701298.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MZW8"/>
    <dbReference type="STRING" id="1459636.NTE_02742"/>
    <dbReference type="GeneID" id="41598432"/>
    <dbReference type="KEGG" id="nev:NTE_02742"/>
    <dbReference type="eggNOG" id="arCOG04330">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_374547_0_0_2"/>
    <dbReference type="OrthoDB" id="99335at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033573">
        <property type="term" value="C:high-affinity iron permease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015093">
        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004923">
        <property type="entry name" value="FTR1/Fip1/EfeU"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31632">
        <property type="entry name" value="IRON TRANSPORTER FTH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31632:SF2">
        <property type="entry name" value="PLASMA MEMBRANE IRON PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03239">
        <property type="entry name" value="FTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="529"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="563"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="597"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="638"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="672"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="730"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="760"/>
            <end position="785"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF84784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="785" mass="85402" checksum="99F549AD62FD5CFE" modified="2014-10-29" version="1">MVGNTMETKNFVVVSALLALLIVAAAVRPALAQTAGSNSDATAMVVLVNLERIRTQVNLAENLLQSGDRDGAFSHAFISHTTVFPSVKAQLSALDAGSTGKLESALTDYAFQIKDGTLSAEQAKGQASQIGVLLDSLAAKTGRASDEDAVSQVSAFLLRDAVQSYRQQDYQSAGGLVDAAYAKYQLVSGSMEESRQQEIESFFSDMKSAMAQKADVDSVAKLQAAIERDLAENLSESEGSGGYAQYFTTIRDLLAKVVSGVQAGNYKQAEQDGITAYLDNFEFLEAPIEKHDAKLMTTIEQQMRVQLREKIQAREAPSAIQDHVNAILANLQTAEGLLKNDPGYSAQAAGSGSSFVSIDELSQGFGAYKGPIKERGDAADTAKEEVRQNIDKIRVKLDETLKIYRDGDAQGAIQASRSAYLDSYENIEIPLRPINPDFTLEMEIKFAELRNQMQAGAPYEQVAAKVVEIRKGLDESERLVTGTGSLAPAIAFSTSFSIIFREGLESALIVGAILTYLEASRNERFKKHVYYGIVLAFAGTAATWFAAQFLIEISGANASIIEAVAGISAVAVLFWVSFWILNKVETKKWIEFVKAKVWKATTTGSVMVFVMLSFFTVYREGFETVLFYQAMLSYAKYMEFYVAAGLAIGLGIIIGVTFLVRKLGKKLPLRVLFGLTMGVGAYMSIAFMGNAIREFQEIGLIETTHLIGTIPRLDINLAAMTGIHPTLETVVAQVALLAVYLAGSIYVLWLQPRRKKAIESARKSRADLDRPATGSKRADIDIEDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MZY7</accession>
    <name>A0A075MZY7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02768</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701318.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MZY7"/>
    <dbReference type="STRING" id="1459636.NTE_02768"/>
    <dbReference type="GeneID" id="41598457"/>
    <dbReference type="KEGG" id="nev:NTE_02768"/>
    <dbReference type="eggNOG" id="arCOG08784">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1902001_0_0_2"/>
    <dbReference type="OrthoDB" id="11104at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="128" mass="14256" checksum="FFFE59DABC4D49DF" modified="2014-10-29" version="1">MSDGKEFWIKLLVKYKGKCAVCGKEIPQGEYALWSRASKAIKHVKCEVQLQQQKEGQRHDEAPEEETSLELKCFVCGKNAGCATCSLEADCNRAIVSQACICESCLSGPDAYDRYQQAFLAKIAKLKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N007</accession>
    <name>A0A075N007_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02789</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N007"/>
    <dbReference type="KEGG" id="nev:NTE_02789"/>
    <dbReference type="HOGENOM" id="CLU_3075490_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="63" mass="6930" checksum="41B22760E4BBFB38" modified="2014-10-29" version="1">MRNADCYLFLSSSNQGLSDNCKGGNHVDCSDCMCKCHIPGTIENLSRNIARLDRKRPGIGETI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N0J4</accession>
    <name>A0A075N0J4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zn-dependent alcohol dehydrogenase</fullName>
            <ecNumber evidence="8">1.1.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NTE_02969</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.1" evidence="8"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701478.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N0J4"/>
    <dbReference type="STRING" id="1459636.NTE_02969"/>
    <dbReference type="GeneID" id="41598640"/>
    <dbReference type="KEGG" id="nev:NTE_02969"/>
    <dbReference type="eggNOG" id="arCOG01455">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_20_1_2"/>
    <dbReference type="OrthoDB" id="8709at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF8">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="7">
        <location>
            <begin position="38"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="6">
        <location>
            <begin position="190"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF85004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="348" mass="36890" checksum="A2F1AD663EEAB8C2" modified="2014-10-29" version="1">MAEEGTMTMKAMVLDRCAPIETKPLKLKSIPVPKPKKRGEVLLEIETCGVCRSNLHMIEGDWKDEGSPSVLPVVPGHEVVGVVKKADGARKVKEGDRVGIQPLFSSCLKCGYCNSGKEHLCDDAEITGESVQGGYAEYIVADEEFVTAIPDSIDSAHAAPLFCPGITAYKAVKASEPARGRSVGIFGIGGVGHLAIQMAKMEGARVVGISRAKKHLDLAKKLGADSTVAYQDSTDQFLKNLKKEEGLLDSAIVFAPSEKAIDAAIKSVKKGGLVVVGVVGEIPHFSAFEEKTIRGTVIGSRQDMADLVALAAGGSLEVVIETHKLAEANDVLARLKHSEVEARAVLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N0V9</accession>
    <name>A0A075N0V9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N0V9"/>
    <dbReference type="KEGG" id="nev:NTE_03080"/>
    <dbReference type="HOGENOM" id="CLU_1840471_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="139" mass="16402" checksum="F3660B4038F2C6B7" modified="2014-10-29" version="1">MRSLYPMSSQNKLTGNRIVVLALLALSLAAVASTFAAPTAVFASSYYDDEDDDDNGSYHHYYYKYYHNDEDDDECGDDDDDDEDDDDNGDDYYWSSYDSDWSHSKYYDDDDEDEDDDDDCDDDEEDDDYSYDHYYWKYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ML06</accession>
    <name>A0A075ML06_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HIT zinc finger</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00037</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699187.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ML06"/>
    <dbReference type="STRING" id="1459636.NTE_00037"/>
    <dbReference type="GeneID" id="41595989"/>
    <dbReference type="KEGG" id="nev:NTE_00037"/>
    <dbReference type="HOGENOM" id="CLU_2911666_0_0_2"/>
    <dbReference type="OrthoDB" id="372368at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="61" mass="6667" checksum="318C972BE68953ED" modified="2014-10-29" version="1">MTTLCYICNARTATLDCADCKRPVCKNCTRDFPFSPGVCLECAQKAKTGLGGIRKDMGEIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLA0</accession>
    <name>A0A075MLA0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00114</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLA0"/>
    <dbReference type="STRING" id="1459636.NTE_00114"/>
    <dbReference type="KEGG" id="nev:NTE_00114"/>
    <dbReference type="HOGENOM" id="CLU_753558_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="367" mass="39679" checksum="5B61F3F9FFCAA98A" modified="2014-10-29" version="1">MAGALFLFALFFGSLAPAYAQSQSQAARSSGGYYYSGTGFDIEFPPGWNGTLADGKYPVARPSSAAAQAGTSMSVFAVNRLEVKNLIMSGVHVLPELDSSSSGRKEEEQQQCQRTLAELVPVNDINVFHTILECADEQQQHYEITDSYIFFTLTKSIAVGYSAPSKDAYNRYLHDFTSSLKTVKVDEPVNIRSGLEIVLGITKFYKKSIDIQAANDAGVDMVIGASSNNVSVVFDEPGKRFVIKVNGQTAATGQAGRLLVPVDKVLRGPYQVHIDGVPVPDPLVIEDTQTKEKLVMVEYGEGARQIVISGAEVVPEFPLHVAGIMLGAVLSASILYQRKKSSSNNNNVKRSGELSLHTRAPLRSHSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLU5</accession>
    <name>A0A075MLU5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative NADP-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_00026</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987075.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLU5"/>
    <dbReference type="STRING" id="1459636.NTE_00026"/>
    <dbReference type="GeneID" id="41595978"/>
    <dbReference type="KEGG" id="nev:NTE_00026"/>
    <dbReference type="eggNOG" id="arCOG01461">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_29_2_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05288">
        <property type="entry name" value="PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000121">
        <property type="entry name" value="Prostaglandin reductase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205:SF7">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="49"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="266"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="277"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF82110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="369" mass="40691" checksum="909A90A1FA8BA845" modified="2014-10-29" version="1">MKSKIVSKEIHLKKRPAGFVTEDDFELVEVEIPEPKREGEFSVRNIWMSVDPWMRIYMVKGSRIMPPVELNKALSGGCIGQVIESKSDNFKVGECVKANFGWREYWAAHDADSSAKNITKVDPKIAPLEYFLGLLGITGITAYVGLFKIGELREGQDTVFVSSAAGGVGSVACQIAKIKGCHVVGSCGSDEKVRWLLDELKVDYAFNYRKLGESNISSELKRACPDGIDLYFDNVGGKHLEAAIDNMNIFGRIVLCGTTSQYNDNNNTSTTSGNVNDPSTPTLSSGPSNLSLAVSHRLRLQGFIWSDHNDILNEFNASMSKWINEGRIKWKESIFEGLENAPKAFVSLFKGESLGRMLVKLGPYTATSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLW8</accession>
    <name>A0A075MLW8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphate ABC transporter, phosphate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NTE_00046</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PstS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLW8"/>
    <dbReference type="STRING" id="1459636.NTE_00046"/>
    <dbReference type="KEGG" id="nev:NTE_00046"/>
    <dbReference type="eggNOG" id="arCOG00213">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG08033">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034528_2_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042301">
        <property type="term" value="F:phosphate ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13565">
        <property type="entry name" value="PBP2_PstS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005673">
        <property type="entry name" value="ABC_phos-bd_PstS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050962">
        <property type="entry name" value="Phosphate-bind_PstS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00975">
        <property type="entry name" value="3a0107s03"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42996">
        <property type="entry name" value="PHOSPHATE-BINDING PROTEIN PSTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42996:SF1">
        <property type="entry name" value="PHOSPHATE-BINDING PROTEIN PSTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12849">
        <property type="entry name" value="PBP_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="481"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="PBP" evidence="5">
        <location>
            <begin position="29"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF82130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="514" mass="53668" checksum="D452A2346DCD8052" modified="2014-10-29" version="1">MHGVGKRTTMIVIAGFFAAVLAMMPMLSAYAQGKIVIDGAGATFPFPLIDTWRVQYQKVNSDVSLNYQSIGSGGGVKQFTEKTVDFGASDAPLTESERGALPGPAVHIPETIGSVVAAYNVPGVEKGLKLTGPVLADIYLGKIKKWNDPQIASENSGVNLPNRDIVVVRRADGSGTTFVWTSYLATVSQEWKDKVGAGKSVEWPVGVGAPGNEGVSNTIGQTPYSLGYVELSYALTTGMDYASIKNKAGNFVEPTLDSTKAAVEAGATSLPAGDASWANVSLLDASGDNSYPIASFSYLLLYKEMSTSPKVDSAQKAKAIVDFIAWAIGPEGQKHAEQLSYVPLPDNVVKLNMQTLGSLTYKSQPVLQQQQQQASDTTVSATFEGKSYPVKVSSSSSAKVTSVAVNAAGQSIDVGFDKPGDVELTLPKAMIDGIQVVSAGGKEVSFQQVGSTATETTIKFTVPDGSAGPVSIKGASVVPEFGVVSALVLAVSLVAVIGIARFKGQASFFGLGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MM08</accession>
    <name>A0A075MM08_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00081</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="124" mass="13403" checksum="484C86D118166E0F" modified="2014-10-29" version="1">MAGSDSKSSKLLTEIIANSLFTPRQVSIISKRLQGGGRPPNMTSGAYYRQVKQCRDKAIAVLYSAILLQSSGALQPEALSAMARLADQLSVIFASEGSSDVFDQARMDDVMSVMDTLVKRVCKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MM56</accession>
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        <submittedName>
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        </submittedName>
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        <name evidence="7" type="ORF">NTE_00118</name>
    </gene>
    <organism evidence="7 8">
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        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
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            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
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        <location>
            <begin position="3"/>
            <end position="114"/>
        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF82200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="117" mass="13233" checksum="2455A015A6CAF231" modified="2014-10-29" version="1">MLYRACASSEIPDDCWKVFTINGTDVLVGKRRGKLFACNNSCPHRGASLAKGDFNGDNIVCHMHGYEYNVFTGKLENMKSWKREATWVEQSPEWRKSGDLVLYPVVEKDGAVYVDLP</sequence>
</entry>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
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    <dbReference type="Proteomes" id="UP000028194">
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82358.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="80" mass="8769" checksum="3B1AAF280B25B0AF" modified="2014-10-29" version="1">MMVTTNTVTARTTITTSSSSLSSPSLTDPFHERLTFLVRSFFFVFVGLLASFGNIEYYVLAGIGVAITLLVARKICDKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMJ7</accession>
    <name>A0A075MMJ7_9ARCH</name>
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        <submittedName>
            <fullName evidence="2">Looped-hinge helix DNA binding domain, AbrB family</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">NTE_00278</name>
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        <lineage>
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            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
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                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
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    <dbReference type="GeneID" id="41596186"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82360.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="92" mass="10512" checksum="35DA49F5AA8CAC4D" modified="2014-10-29" version="1">MQKVKVSPKGQVVIPKPLRDKFGIRKGDEVVVKESRRGILVMKREEDPLKAMIGLFEGKANRPSTEMVREIRKQSEARIKKEAKKDQAVREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMS0</accession>
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        <submittedName>
            <fullName evidence="3">Lactoylglutathione lyase family protein</fullName>
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        <name evidence="3" type="ORF">NTE_00646</name>
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    <organism evidence="3 4">
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
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    <dbReference type="eggNOG" id="arCOG04946">
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    <dbReference type="HOGENOM" id="CLU_127592_3_1_2"/>
    <dbReference type="OrthoDB" id="134577at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07247">
        <property type="entry name" value="SgaA_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052164">
        <property type="entry name" value="Anthracycline_SecMetBiosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33993">
        <property type="entry name" value="GLYOXALASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33993:SF2">
        <property type="entry name" value="VOC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="3"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF82726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="122" mass="13654" checksum="40052CC163448758" modified="2014-10-29" version="1">MPRPCHFDLTADNPERAIKFYSNVFGWQFEKWDGPMEYWMCTTGDKDAPGINGGLSKRGQQSMPNMNTIDVPDVDEFSKKITSSGGKVVMPKMAIPGVGWFATCQDTEGNLFGIIREDRNAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMT1</accession>
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            <fullName evidence="2">AsnC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
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            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMT1"/>
    <dbReference type="KEGG" id="nev:NTE_00378"/>
    <dbReference type="HOGENOM" id="CLU_2730555_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription regulator AsnC/Lrp ligand binding" evidence="1">
        <location>
            <begin position="9"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="77" mass="8599" checksum="177EFD5F40BCC2D0" modified="2014-10-29" version="1">MIPIGFMFIECVEGSQNDLLQRIKEIPGVSYAYKLDKTYNLVVKVESDSVDKFALAIAQIRKLGNLLNTDTMVGFKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMX3</accession>
    <name>A0A075MMX3_9ARCH</name>
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        <recommendedName>
            <fullName evidence="4">IPT/TIG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00716</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699696.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMX3"/>
    <dbReference type="STRING" id="1459636.NTE_00716"/>
    <dbReference type="GeneID" id="41596569"/>
    <dbReference type="KEGG" id="nev:NTE_00716"/>
    <dbReference type="HOGENOM" id="CLU_1275263_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="38"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="163"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="216" mass="21291" checksum="9D926BA73AB21AE2" modified="2014-10-29" version="1">MSETRMYAAQAVVVGLAIIAAMAVMPGFVATNNAVAQSGNETSTTTGNETSTTTNPSTTPSTPGNNETSTTGASITLTPASGAPGSNVTIAGTGFLPGQTFKFTFDDGYLLSGNMIQDTFGNFNTTVLVPANTTSGDHQVAVAGSAGENATATFSVGEGAREGSAGNATSTGNSTTTMTTPSGGNETAVPSETGNSTTIAPPSSGNTTTPLMPESP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMX7</accession>
    <name>A0A075MMX7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Yip1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMX7"/>
    <dbReference type="KEGG" id="nev:NTE_00728"/>
    <dbReference type="eggNOG" id="arCOG03769">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_147147_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="154" mass="16632" checksum="7749D44A6C673512" modified="2014-10-29" version="1">MNDILLLDPLFLQVNGNFVIAALALIFGLLILWILVSIPVWIAAKIVTAGRARFTRAMLVTAAGPITYAIVFFLSSAILEMTLGEKIFITTIAFILAFIAWIGVFKLGFDTGWLRALGIAILATIVFAVIGTIITIGLQALVPETPPITPFPTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MN10</accession>
    <name>A0A075MN10_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00798</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699758.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MN10"/>
    <dbReference type="STRING" id="1459636.NTE_00798"/>
    <dbReference type="GeneID" id="41596647"/>
    <dbReference type="KEGG" id="nev:NTE_00798"/>
    <dbReference type="HOGENOM" id="CLU_2856919_0_0_2"/>
    <dbReference type="OrthoDB" id="379031at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="64" mass="6948" checksum="50E108A770A5750B" modified="2014-10-29" version="1">MHGGHDDDDSEQAVIRDYKDSLVRGLAPSTITVWIEKIVETANALCGSSSAAIKYKKGEAIWAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MN24</accession>
    <name>A0A075MN24_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HEAT repeats</fullName>
            <ecNumber evidence="1">1.14.99.29</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00828</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.14.99.29" evidence="1"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987154.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MN24"/>
    <dbReference type="STRING" id="1459636.NTE_00828"/>
    <dbReference type="GeneID" id="41596672"/>
    <dbReference type="KEGG" id="nev:NTE_00828"/>
    <dbReference type="eggNOG" id="arCOG04006">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1754610_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019135">
        <property type="term" value="F:deoxyhypusine monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697:SF5">
        <property type="entry name" value="DEOXYHYPUSINE HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697">
        <property type="entry name" value="PBS LYASE HEAT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13646">
        <property type="entry name" value="HEAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="171" mass="18943" checksum="402556525B2DB896" modified="2014-10-29" version="1">MAAKKQQVHINNDNSRLKLFEEMEAQFDEKNVDYFKKLLTHQDSVVRTRAVCILAEIAGESAVTPISKVLKNDDNDLVRHEAAFSLGQLGFSSGIKPLADAVENDKSFFVRHEAAVALGVIGSEDARKTLDYALKNDESEEVRDSAVVALANLDYIKAVNRKNDFTRMTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MN28</accession>
    <name>A0A075MN28_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_00582</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699588.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MN28"/>
    <dbReference type="STRING" id="1459636.NTE_00582"/>
    <dbReference type="GeneID" id="41596446"/>
    <dbReference type="KEGG" id="nev:NTE_00582"/>
    <dbReference type="HOGENOM" id="CLU_812853_0_0_2"/>
    <dbReference type="OrthoDB" id="10392at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF82663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="359" mass="39384" checksum="56981B2E35EF5EB6" modified="2014-10-29" version="1">MAAIRDDNEAETNNIGDRIKRLLLSSSSPQPTNIRKRLVLVLVAAVLVVSIPVLLMGVSQKPNPAPPMSSSTTATTTTTTTRNPSSSKDRFGITELYPTSPDGMEWSSSWDNGHARTIGNAIDPDDKWFDAAHGEGMYAIDGKGTLTASGDFVRMYVHDPAKEREWSENLEITLYVKRISETQIVDYSGLQVFARTNHGTNGNEEVNLCDDRGYGGLININGEWTLEKETAHHLDNGYVDVAGQRPSGDLPKNTWVGFKYVLRNMDDNTKVKLELYRDTTGGANGGNWQKVTEFVDNGDSFGAGYGACRSGVNPALPLIHSFINDSSETGKPMLSVYARHEYGTMAYSDFTIREISSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MN34</accession>
    <name>A0A075MN34_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Plastocyanin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00587</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MN34"/>
    <dbReference type="STRING" id="1459636.NTE_00587"/>
    <dbReference type="KEGG" id="nev:NTE_00587"/>
    <dbReference type="eggNOG" id="arCOG02926">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_736931_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052721">
        <property type="entry name" value="ET_Amicyanin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36507">
        <property type="entry name" value="BLL1555 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36507:SF1">
        <property type="entry name" value="BLL1555 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="375" mass="39638" checksum="5E28E95A49B8900B" modified="2014-10-29" version="1">MTSKDPSMGFLDAKNHSGMFIITAFALIAALANTGTIATGGGAKFALAQQAPPKGEPQTEADHTVSIANGTAQRGVKSTFNPATITVRDGSLLTFLNRDVVEHSAVAGTAKNGPTGQFDTDVIEPGKNVTISINDKPGATIQYFCKIHPFLTGTIKIAANEEAGGGATETQPQQQQQQQRQTTNNNNNSVTTFTASGPIASWASGPSATADSNVTLLPYVISGAWNLKVVNGTAKSFDANITMVKADGTDFHTHRLLNFRAASASLANTLLFNQTENNNNTSSNNRTEIAAAPLTVAGAQSELSIPGHIDITTDGNETWPDVSVNVMIRQWHTINIVMDENATNKHFTEGHYAPAIYGGVSSVKDKDGKELLVQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MN76</accession>
    <name>A0A075MN76_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Translation initiation factor 1A</fullName>
            <shortName evidence="2">aIF-1A</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">eif1a</name>
        <name evidence="5" type="ORF">NTE_00524</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-1A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MN76"/>
    <dbReference type="STRING" id="1459636.NTE_00524"/>
    <dbReference type="KEGG" id="nev:NTE_00524"/>
    <dbReference type="eggNOG" id="arCOG01179">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109098_1_2_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05793">
        <property type="entry name" value="S1_IF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00216">
        <property type="entry name" value="aIF_1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001253">
        <property type="entry name" value="TIF_eIF-1A"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003084">
        <property type="entry name" value="PRK04012.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003085">
        <property type="entry name" value="PRK04012.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21668">
        <property type="entry name" value="EIF-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00652">
        <property type="entry name" value="eIF1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2 3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1-like" evidence="4">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF82605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="89" mass="10162" checksum="58C312575B56D62C" modified="2014-10-29" version="1">MMVPGQGQLFGRVIKLVGGDNIVVKCTDGKVRTCRIRGKIKRRMWIRDNDLVLVAPWDFQSERADIIWRYISAHAEKIKQDGHLAGLDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MND6</accession>
    <name>A0A075MND6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative xylanase/chitin deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_00589</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699593.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MND6"/>
    <dbReference type="STRING" id="1459636.NTE_00589"/>
    <dbReference type="GeneID" id="41596452"/>
    <dbReference type="KEGG" id="nev:NTE_00589"/>
    <dbReference type="eggNOG" id="arCOG02876">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG09729">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019209_0_0_2"/>
    <dbReference type="OrthoDB" id="306789at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059177">
        <property type="entry name" value="GH29D-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13290">
        <property type="entry name" value="CHB_HEX_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0858">Xylan degradation</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="2">
        <location>
            <begin position="47"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF82670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="542" mass="58823" checksum="7DE31ED4F42379E2" modified="2014-10-29" version="1">MVLAPKGIVQCSTASVLAVMLVLSSVFVGIGSSYYYSAKPAFAASCDCVIFRLDDVQDYWINNVQVAVMDKFISKNTRLTLGEIMNFFGSDSLVVDKTKQEGNAGLFEYALHGWNHDDYTTFSQSKQQSELQKANDKRQSLYGKKSNIFITPYNVFNANTLTAMQNLGLKVISADMFASYYEDNPSTPLAPSADNRGIYHAPEVTAFSEWTNNQHFQLTSSQILSGIDSSIEERGWAVVTLHPQDFSNYAPDGVTALNSVNANSIARIDSVINGISSRGYSIKSFNELVGIASPPSDTTPPVVTAMPAGGSYPSAQSVTLTANEQATIYYTTNGSAPTTSSPIYSSPISITATTTLKFFARDTAGNSSPVRTEIYTISPGTFPVTRMSDTTQTYGLSLYSATQSHVEFVSSSASQLAGKSINEITLKLRKTGAPTGTVQVGIFNPDLTVKKLFGTKDATTITTTYTDYVFTLSSNELYTIQSGDRIGIKYAGGNSNNFIAVMLDRDAADPFDGTNTYRQQYGTSWLGYTGDDMYMILKQTHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNF2</accession>
    <name>A0A075MNF2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dehydrogenase, PQQ-dependent, s-GDH family</fullName>
            <ecNumber evidence="2">1.1.5.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01007</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.5.2" evidence="2"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987174.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNF2"/>
    <dbReference type="STRING" id="1459636.NTE_01007"/>
    <dbReference type="GeneID" id="41596833"/>
    <dbReference type="KEGG" id="nev:NTE_01007"/>
    <dbReference type="eggNOG" id="arCOG02796">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012253_4_1_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008876">
        <property type="term" value="F:quinoprotein glucose dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012938">
        <property type="entry name" value="Glc/Sorbosone_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH_b-prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019893">
        <property type="entry name" value="SndH-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03606">
        <property type="entry name" value="non_repeat_PQQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19328">
        <property type="entry name" value="HEDGEHOG-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19328:SF13">
        <property type="entry name" value="HIPL1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07995">
        <property type="entry name" value="GSDH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="Soluble quinoprotein glucose dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose/Sorbosone dehydrogenase" evidence="1">
        <location>
            <begin position="70"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose/Sorbosone dehydrogenase" evidence="1">
        <location>
            <begin position="386"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="499" mass="54050" checksum="EA78037F54E5DB4D" modified="2014-10-29" version="1">MGKIRPLLLSGLAGALLLVSLVTFYTPETQASDTPFSNNSTLGANNNTTSIMRLPSQEGFSVRLLAANFSAPYNILYGPDGALWITERVGKVITRVDPESGSKLGSIPVPNVHQSAPQDGLMGMAFDPAFNNTHHIYVAYTYDADPSDALDRRVKITRFTYDAAAGTIGNPVDLISGLYGSTDHNSGRMTFGPDGKLYYTIGDQGKNYLANYCLENQAQSLPTAEQVAARNWTAYQGKVLRMNPDGSIPDDNPVINGVRSHILTYGHRNPQGIAVGPNGNSLYVSEHGDKSDDELNRLQAGGNYGWPNVAGYNDDKAYQYVNWSGAKNCKDLKFDNTAPPPPGVPVMNESEFDAPNFVPPVHTFYTVENGYNFRDPACGDLTYICWPTVAPSSLRLYTSDAIPGWQDTFLMTTLKAGKIFQLALDENGTALARDPVELFRSENRYRDLAFSPDGSTIYVITDSSGPAQAIGGGATINLWNPGSVLVFRYEGTGGASMSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNH2</accession>
    <name>A0A075MNH2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Signal peptidase I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NTE_00620</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699619.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNH2"/>
    <dbReference type="STRING" id="1459636.NTE_00620"/>
    <dbReference type="GeneID" id="41596483"/>
    <dbReference type="KEGG" id="nev:NTE_00620"/>
    <dbReference type="eggNOG" id="arCOG01739">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102051_0_0_2"/>
    <dbReference type="OrthoDB" id="4822at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.109.10">
        <property type="entry name" value="Umud Fragment, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001733">
        <property type="entry name" value="Peptidase_S26B"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02228">
        <property type="entry name" value="sigpep_I_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806:SF6">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S26" evidence="7">
        <location>
            <begin position="22"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="166"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF82700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="198" mass="21060" checksum="8D56FEE01488CE5A" modified="2014-10-29" version="1">MEQKSKLPVAMRDIIIVVAGVAIVWLGLRLAFDTNNPFYVVSSRSMVPVLQVNDVLVVRDGGSWDTLKVGDIIVFDRPDGEDRVIVHRVAEIGENSAGERVIRTKGDANPASIPGTDFPIHKDNYIGKVVYVLPGAGVITKIISPPVNYIIIAIILVILFFSKWGRKGSSSSGASQPPSSSSSSPSSGATSPPPPPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNM2</accession>
    <name>A0A075MNM2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MtN3 and saliva related transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NTE_01083</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699974.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNM2"/>
    <dbReference type="STRING" id="1459636.NTE_01083"/>
    <dbReference type="GeneID" id="41596899"/>
    <dbReference type="KEGG" id="nev:NTE_01083"/>
    <dbReference type="eggNOG" id="arCOG05022">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2010169_0_0_2"/>
    <dbReference type="OrthoDB" id="11322at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051119">
        <property type="term" value="F:sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047662">
        <property type="entry name" value="SemiSWEET"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037968">
        <property type="entry name" value="SemiSWEET_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF83156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="123" mass="13350" checksum="BB766878EC22A850" modified="2014-10-29" version="1">MAGFLTPGGQWAAVPLLLPPSQVLLLQVISDGIFITLVGSAAACLTTSSFLPQIFKGYRTKKMQDVSPYLMALYASGTTLWLAYGIFKDDWVIIGANALGTAFNLLLLYMKRIYRRPSSSLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNP5</accession>
    <name>A0A075MNP5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Small-conductance mechanosensitive channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NTE_00670</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699658.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNP5"/>
    <dbReference type="GeneID" id="41596529"/>
    <dbReference type="KEGG" id="nev:NTE_00670"/>
    <dbReference type="eggNOG" id="arCOG01570">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_878796_0_0_2"/>
    <dbReference type="OrthoDB" id="11352at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008910">
        <property type="entry name" value="MSC_TM_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045275">
        <property type="entry name" value="MscS_archaea/bacteria_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_beta-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30221">
        <property type="entry name" value="SMALL-CONDUCTANCE MECHANOSENSITIVE CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30221:SF1">
        <property type="entry name" value="SMALL-CONDUCTANCE MECHANOSENSITIVE CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05552">
        <property type="entry name" value="MS_channel_1st_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Mechanosensitive ion channel MscS" evidence="7">
        <location>
            <begin position="241"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="295"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="301"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="313"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF82750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="322" mass="34179" checksum="18C3AC111C459718" modified="2014-10-29" version="1">MSFEISGILTLLTTFQAAGANDLTTPIVNSLNQFGTTLGAALPRIIAALILLGIGYLVGKIAGWVVSRVIKALNLDKHWSKSGIGQATVSSGWSMSRIFGTATKWFIYLFFIAAAVNALQFPQISQAINSVWLWVPNVVAFLLVLVIGSLLADFVGSWVQRELPRRGIMAGKTIGLAITGILYAIVLTVAVTQLGIGQQILNSVISALIWSLAAAIAIGFGVGLAYGLREAIPSLIKGNTLIQPAIKQGQRISVNQHRGVVQEVGAFSVIIKDEEGRTVVIPTKNLVDEEIIVESGPTPETQERVMERGGEGPSSTSYSAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNU2</accession>
    <name>A0A075MNU2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tritrans,polycis-undecaprenyl-diphosphate synthase (geranylgeranyl-diphosphate specific)</fullName>
            <ecNumber evidence="4">2.5.1.89</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Undecaprenyl diphosphate synthase</fullName>
            <shortName evidence="4">UDS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Undecaprenyl pyrophosphate synthase</fullName>
            <shortName evidence="4">UPP synthase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">uppS</name>
        <name evidence="5" type="ORF">NTE_00400</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>geranylgeranyl diphosphate + 7 isopentenyl diphosphate = tri-trans,hepta-cis-undecaprenyl diphosphate + 7 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:27622"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57533"/>
            <dbReference type="ChEBI" id="CHEBI:60388"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="2.5.1.89"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="4">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the UPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.89" evidence="4"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_193354083.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNU2"/>
    <dbReference type="STRING" id="1459636.NTE_00400"/>
    <dbReference type="GeneID" id="41596281"/>
    <dbReference type="KEGG" id="nev:NTE_00400"/>
    <dbReference type="eggNOG" id="arCOG01532">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038505_2_0_2"/>
    <dbReference type="OrthoDB" id="8293at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045547">
        <property type="term" value="F:ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016094">
        <property type="term" value="P:polyprenol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1180.10:FF:000003">
        <property type="entry name" value="Isoprenyl transferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="entry name" value="Decaprenyl diphosphate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01139">
        <property type="entry name" value="ISPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018520">
        <property type="entry name" value="UPP_synth-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00055">
        <property type="entry name" value="uppS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291:SF43">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT DHDDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="Undecaprenyl diphosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01066">
        <property type="entry name" value="UPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4 5" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="4">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="51"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="95"/>
            <end position="97"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="228"/>
            <end position="230"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF82482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="273" mass="32112" checksum="7F6963B138EE39A2" modified="2014-10-29" version="1">MGLSEDFDRGGRAVMDGLLHASRIYSYYERRLENEILSQPLPNHIAIILDGNRRWARYHFLDTEMGHAHGADRAEDLLNWIHDIGVRITTLYILSNENLERDDEELENIYRLLEVKLNRLYNDERIHRRQMKIKAIGDKHRLPRSLQEILGKLEEATAEYEKMFLNIAVAYGGQKELVDAVKKIAGMAKNNEIKIEDINEKTIEACLYTSHLPQSSPDLILRTSGEKRLSGFLIWQSAYSELMFMDVFWPEFRKIDLMRAIRTYQRRVRRYGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MP21</accession>
    <name>A0A075MP21_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cob(II)yrinic acid a,c-diamide reductase</fullName>
            <ecNumber evidence="8">1.16.8.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NTE_00833</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.16.8.1" evidence="8"/>
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        <property type="protein sequence ID" value="AIF82910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="eggNOG" id="arCOG00288">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070764_3_1_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="5,6-dimethylbenzimidazole synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NADH Oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BluB"/>
    </dbReference>
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        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
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    </dbReference>
    <dbReference type="InterPro" id="IPR050627">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <begin position="32"/>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF82910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="254" mass="29056" checksum="015C827D1168937E" modified="2014-10-29" version="1">MRQSTETRTVAERGVDYAFSGPEKEGLYKAIFSRRDVRSHFVRNKDIPDDALLRILNAAHHAPSVGFSQPWNFILIKDAQTRKRVKESFERERERSIKMLENDKEKQERYARLKLEGIMESALNICVTYDPTRFGPFVLGRTSIEDTGVYSVCCAIQNLWLAARAEGVGVGWVSILSNEDLERILGIPAHVKPVAYLCLGYVEEFAQKPDLERAGWLPRMDLAKVICYEKWGKQESEKWSGLCDAVSRLSRNNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="AIF82950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="114" mass="13082" checksum="BDD730294F6D2CDA" modified="2014-10-29" version="1">MKIFGEKIQASVERVISSPRTREREIANAWKALLLERSENGPRAFKIDMDTFAHHYQQEYGKDMPVEIDAKTITEILAKGRLAYPVDHDEGKVCHFWYADGVASWTLVAQKEDS</sequence>
</entry>
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    <accession>A0A075MPA4</accession>
    <name>A0A075MPA4_9ARCH</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">NTE_00541</name>
    </gene>
    <organism evidence="1 2">
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        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
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            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="43502568"/>
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    <dbReference type="Proteomes" id="UP000028194">
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="57" mass="6698" checksum="A33B5BD471F8C099" modified="2014-10-29" version="1">MSPATKSFDTEEMKENLEFVVIHLAEHADFRGEIKELDKDCVICQHYFSDELSEHRV</sequence>
</entry>
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    <accession>A0A075MPC0</accession>
    <name>A0A075MPC0_9ARCH</name>
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        <recommendedName>
            <fullName evidence="2">PspA-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">NTE_00983</name>
    </gene>
    <organism evidence="3 4">
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        <lineage>
            <taxon>Archaea</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83058.1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="OrthoDB" id="145362at2157"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR054437">
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF83058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="145" mass="16039" checksum="DD5EA9EB3EA2E72B" modified="2014-10-29" version="1">MKKKVKAKAKARKRAKVVAKNKPRRAKKIIRLAQKKSRPKKAKMAPAAAKKVVRIMGHGQFTVDARTLKRLNDIDSELVEMVASEKADDVGFKKKLAELNQITIKHGKAVEPGEIVRSDIILPSADLPVDEAKKLFVGEGVIPEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPS0</accession>
    <name>A0A075MPS0_9ARCH</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
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        <name evidence="2" type="ORF">NTE_01047</name>
    </gene>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83120.1"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="176" mass="18494" checksum="71D417179B804433" modified="2014-10-29" version="1">MKRGYYVLIGGAALFAIGIALTVVWALPVAQQLQKDTTILQQVSLAAAKSASAEFQVADPERMLSVVVSARNSAPMTAVLVGPDGSEVLRKEFSETLAEGTVPTQAGSYRLTVTNNGSTDTTVDVVLGYIPGVGQDNNVNVEMFRGVIIGAGMIIAGIMVMIGGVIVVVLDRRKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQ43</accession>
    <name>A0A075MQ43_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative metal-dependent protease of the PAD1/JAB1 superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NTE_01618</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
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            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987228.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQ43"/>
    <dbReference type="STRING" id="1459636.NTE_01618"/>
    <dbReference type="GeneID" id="41597397"/>
    <dbReference type="KEGG" id="nev:NTE_01618"/>
    <dbReference type="eggNOG" id="arCOG01139">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116578_1_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028090">
        <property type="entry name" value="JAB_dom_prok"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14464">
        <property type="entry name" value="Prok-JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="JAB" evidence="6">
        <location>
            <begin position="21"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF83681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="136" mass="15329" checksum="DA192A1579E3971C" modified="2014-10-29" version="1">MFKKAEQEKKEEKIVLLTRQAADGIITFSKTYHPNEAILILQGKKKGNEITINGLVIPPFSSNGPFYSGFSLYDLPFDDSYIGTAHSHPGPSNRPSLEDLNHFFGYVSVIIHFPYEYGTIAAYERTGKKMEIKIVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQ57</accession>
    <name>A0A075MQ57_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycinamide ribonucleotide synthetase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Phosphoribosylglycinamide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NTE_00936</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the GARS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699866.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQ57"/>
    <dbReference type="STRING" id="1459636.NTE_00936"/>
    <dbReference type="GeneID" id="41596771"/>
    <dbReference type="KEGG" id="nev:NTE_00936"/>
    <dbReference type="eggNOG" id="arCOG04415">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027420_3_0_2"/>
    <dbReference type="OrthoDB" id="315187at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004637">
        <property type="term" value="F:phosphoribosylamine-glycine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.600.10">
        <property type="entry name" value="Phosphoribosylglycinamide synthetase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020561">
        <property type="entry name" value="PRibGlycinamid_synth_ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000115">
        <property type="entry name" value="PRibGlycinamide_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020560">
        <property type="entry name" value="PRibGlycinamide_synth_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037123">
        <property type="entry name" value="PRibGlycinamide_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43472">
        <property type="entry name" value="PHOSPHORIBOSYLAMINE--GLYCINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43472:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLAMINE--GLYCINE LIGASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01071">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02843">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01209">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01210">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoribosylglycinamide synthetase C-domain" evidence="8">
        <location>
            <begin position="312"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00042864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF83012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="423" mass="47189" checksum="EC45EEAB4413EB37" modified="2014-10-29" version="1">MKFLFVSPEALSLDLAYRIVQEGHEVKFCVQSETEKDVGDGFVEKADKWEDHVLWADVIVFDDIGFGRAAEKLRAEGKKVVGGSAYTDRLESDREFGQNELARAGVSTLQGRTFSDFEEAINFVQANPSRYVIKPSGKAQNDKELLFVGQEADGNDVINVLAHYKKHWSSKIRVFQIQQFASGVEVAVGAFFNGKDFVKPINVNFEHKRLFPGDIGPSTGEMGTLVFWTHQSRIFGLTLEKMKQQLVESGYIGYIDINCIANGTAIYPLEFTSRFGYPTISIHMEGITGQWGQFLYSIASGQSVELEAKKGFQIGVVIAVPPFPFTDDKTFRKFSEDATVLFKQPDMAGVHLGEIKKDGSDWRIAGRSGYALVVTGSGITTEEARRQAYSRVANIMIPNMFYRTDIGAKWIKDSDLLLSLGYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQC2</accession>
    <name>A0A075MQC2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Aspartate--tRNA(Asp) ligase</fullName>
            <ecNumber evidence="9">6.1.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Aspartyl-tRNA synthetase</fullName>
            <shortName evidence="9">AspRS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Discriminating aspartyl-tRNA synthetase</fullName>
            <shortName evidence="9">D-AspRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">aspS</name>
        <name evidence="11" type="ORF">NTE_01665</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Asp) + L-aspartate + ATP = L-aspartyl-tRNA(Asp) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9660"/>
            <dbReference type="Rhea" id="RHEA-COMP:9678"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.12" evidence="9"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700445.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQC2"/>
    <dbReference type="STRING" id="1459636.NTE_01665"/>
    <dbReference type="GeneID" id="41597440"/>
    <dbReference type="KEGG" id="nev:NTE_01665"/>
    <dbReference type="eggNOG" id="arCOG00406">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004553_2_1_2"/>
    <dbReference type="OrthoDB" id="5908at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00776">
        <property type="entry name" value="AsxRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000038">
        <property type="entry name" value="Aspartate--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02075">
        <property type="entry name" value="Asp_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004523">
        <property type="entry name" value="Asp-tRNA_synthase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00458">
        <property type="entry name" value="aspS_nondisc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003483">
        <property type="entry name" value="PRK05159.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450:SF1">
        <property type="entry name" value="ASPARTATE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450">
        <property type="entry name" value="ASPARTYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="10">
        <location>
            <begin position="137"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Aspartate" evidence="9">
        <location>
            <begin position="192"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="213"/>
            <end position="215"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="221"/>
            <end position="223"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="354"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="354"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="354"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
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    <feature type="binding site" evidence="9">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="402"/>
            <end position="405"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
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        <location>
            <position position="84"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005312"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIF83726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="431" mass="48232" checksum="09B7E7FF7A53A399" modified="2014-10-29" version="1">MVIVDIHRTHYARQLGEGLVGSQVRIGGWIEDVRDIGKLAFMTIRDVTGACQAIVTGDNVQAAVQAPRQSAVIVAGTVQKSKAKDFPVEVKVTEFTILTKAVHPLPIDPTGRVESAPDKRLDARALDLRNPKVAAIFHLRSAGLKVVRDTLRGEGFVEVNTPKIIGSASEGGANLFGFDYFKRKAYLAQSPQLYKEQLTLGLDRVFEIGPYFRAENSHTVRHLTEFTSIDVEAAFLDYEDVMDLVEKVVGNVIRDFNENHKAELAAAGAQEIPFSGKIDRLTYEQCLDELAKEGEKLSFGEDLSDAALRKLGEIHRGFYFIMDWPLKLKPFYIHEKEGDERLSKSFDLQHGYLELVSGGRRLHDPERLRSRLAEQGLNPASFSEHLKAFDWGMPPHSGWGLGYDRLMMVLTGSQNVRDVVLYPRDTDRLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQG9</accession>
    <name>A0A075MQG9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative divalent heavy-metal cations transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
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            <taxon>Nitrososphaerales</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385183.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQG9"/>
    <dbReference type="STRING" id="1459636.NTE_01396"/>
    <dbReference type="GeneID" id="41597192"/>
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        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="11839at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="404" mass="41702" checksum="6E3FEE2C8D693B66" modified="2014-10-29" version="1">MTTTITNAKLAASALIPIVILAGMIAFLLWPGNTVLNFGAPLPDVTVERIEFASKLIIAHVRNTGPQAAEIAQVDVNDRIVPAAVEPSKDLARFGEARVVIPFEWVEGKPYEVGVTTSDGVRFAKAVPAAILTPAPDAGQASLLALLGTYVGIIPVMIGLLWLPFLKRLSAGKYLFFLSFTAGLLLFLGIDALVEANELATKSVAGAFHGQALIATVTVVSFVALLYASEKLVERGKTTTTTTTTTTKARTITGSIAVALMISVGIGLHNMGEGLAIGGSMVAGEVALGAFLIVGFTIHNTTEGLAIVAPLARERPKVAQLAALGFIAGAPAILGAWVGGFVSSPVASVVFLAVGAGAVFQVVYAIFKYTGRQESAGGSKFLSGPVAAGIAIGMLVMYLTSLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQM1</accession>
    <name>A0A075MQM1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Conserved protein of DIM6/NTAB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_01449</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the flavoredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700273.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQM1"/>
    <dbReference type="STRING" id="1459636.NTE_01449"/>
    <dbReference type="GeneID" id="41597244"/>
    <dbReference type="KEGG" id="nev:NTE_01449"/>
    <dbReference type="eggNOG" id="arCOG01083">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG02017">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_923221_0_0_2"/>
    <dbReference type="OrthoDB" id="8522at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052174">
        <property type="entry name" value="Flavoredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43567:SF1">
        <property type="entry name" value="FLAVOREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43567">
        <property type="entry name" value="FLAVOREDOXIN-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin reductase like" evidence="4">
        <location>
            <begin position="9"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF83513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="307" mass="33616" checksum="05F9BD006AC87CE6" modified="2014-10-29" version="1">MPDIQDNAHRYFATSVALVTTDGKSGKNVMAAEWAMQVSYEPMLIAIFIHDSPTLWNIKENGMFGVNIAADDQAEIVNIAGGYSGTEIAKLAIPQTFQTYAGKGVPMIKGCALACECKVMSVQEMGDHVMVVGEAISATFDEKKSPLIYTRGNYRKIGGKLASGRKTVRLSPKAFAEFKRMSGGQFVLKAAVAVVRDGRKTLFVRMESSSSWMLPAVVPERGTDYKKAVSLHLKSIGVQAQIEGIAGIERMMLKSGKQQSLRANFVVFSCTANAIKEDDDNNDNKKGWFLHPPRNLLLKSLLLFQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQQ4</accession>
    <name>A0A075MQQ4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQQ4"/>
    <dbReference type="STRING" id="1459636.NTE_01480"/>
    <dbReference type="KEGG" id="nev:NTE_01480"/>
    <dbReference type="HOGENOM" id="CLU_2340014_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="97" mass="10423" checksum="06DC94C6F60F9060" modified="2014-10-29" version="1">MLSSISEFPMVNLEQQLSMTEGQRPPRKGGAVSFLLCNSCYWCASSITELTGDDLHCPSCGQVVESIPLGTGEVFSLGIDAKRGVVLEFKKALRNAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQY9</accession>
    <name>A0A075MQY9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Tryptophan synthase alpha chain</fullName>
            <ecNumber evidence="9">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">trpA</name>
        <name evidence="11" type="ORF">NTE_01912</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 13">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + L-tryptophan + H2O</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 9">Tetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the TrpA family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="9"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700638.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQY9"/>
    <dbReference type="STRING" id="1459636.NTE_01912"/>
    <dbReference type="GeneID" id="41597661"/>
    <dbReference type="KEGG" id="nev:NTE_01912"/>
    <dbReference type="eggNOG" id="arCOG01086">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016734_0_4_2"/>
    <dbReference type="OrthoDB" id="25658at2157"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04724">
        <property type="entry name" value="Tryptophan_synthase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000037">
        <property type="entry name" value="Tryptophan synthase alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00131">
        <property type="entry name" value="Trp_synth_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018204">
        <property type="entry name" value="Trp_synthase_alpha_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002028">
        <property type="entry name" value="Trp_synthase_suA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00262">
        <property type="entry name" value="trpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43406:SF1">
        <property type="entry name" value="TRYPTOPHAN SYNTHASE ALPHA CHAIN, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43406">
        <property type="entry name" value="TRYPTOPHAN SYNTHASE, ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00290">
        <property type="entry name" value="Trp_syntA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00167">
        <property type="entry name" value="TRP_SYNTHASE_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7 9 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIF83971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="279" mass="30054" checksum="B540D8F2378FB068" modified="2014-10-29" version="1">MQQESNKNRIDARFANLAENKECALVCYVVAGFPDFQTTAQIIDALVEGGADIIEIGIPFSDPIADGPTIQRASQAALERGSTPAKALQLAKQVRKKHPSLPLLVMTYSNLFVKPGWGDFIAKCKEAGIDGFILPDMPVEEASEYLPKAAHNGMATVFLASPNTPEERLKKIAQNSSGFMYLVSVYGITGARRTFENYTKDAVQRAKKAAGGKIPVGVGFGISKPEHARFMVNAGADAIIVGSALVDRISNAKNNRKAMLKELKAFSASLKKACYSSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRH5</accession>
    <name>A0A075MRH5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01692</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700466.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRH5"/>
    <dbReference type="STRING" id="1459636.NTE_01692"/>
    <dbReference type="GeneID" id="41597462"/>
    <dbReference type="KEGG" id="nev:NTE_01692"/>
    <dbReference type="HOGENOM" id="CLU_2765846_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="69" mass="7819" checksum="670388F184F59865" modified="2014-10-29" version="1">MNDRDDDNGGEREWISKSGESDVFKEYENKVERFLAGLNETISKLHKAGHLDDAAYSRLGKLARDFQGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRH8</accession>
    <name>A0A075MRH8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01628</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRH8"/>
    <dbReference type="STRING" id="1459636.NTE_01628"/>
    <dbReference type="KEGG" id="nev:NTE_01628"/>
    <dbReference type="eggNOG" id="arCOG08675">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_929436_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.570">
        <property type="entry name" value="Particulate methane monooxygenase, b subunit. Chain: A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023301">
        <property type="entry name" value="NH3_CH4_mOase_suB_N"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="320"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="351" mass="38610" checksum="E9D307D49DB3CFFC" modified="2014-10-29" version="1">MFIATGVLLLSFAYTLENNAYAHNISPGVRSLPVRIDNEQFSSNRANTDGGFIAVTGTLTSLATERIKVSPYIFVTPSEWVGANGVRHGTLPYYDLLAFIYPPYRDQSNWYFRVELNNLPSSIVLEPGEKVDYEIQIYPLKAGAYHVHSFFLSENFARSGLGQTILVTGSSAPTTGEITQLYLPLVLGLTSFVILIIRIMQISRENAHLARERIARVYFAAKSSLETMWLAGVLFWLATAAPYFPAIESRYAFALSASAVLAAIVIGGYVSAAAKQNARHLAFAIMTSAVSAAFCFALLFGEGWLYPYYKELHFLVDGSALFLAMIANSIIAIYFAVMARKEGKNKLTSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRL8</accession>
    <name>A0A075MRL8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Copper-containing nitrite reductase</fullName>
            <ecNumber evidence="3">1.7.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">NTE_01395</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>nitric oxide + Fe(III)-[cytochrome c] + H2O = Fe(II)-[cytochrome c] + nitrite + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15233"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.7.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Cu(+)</name>
            <dbReference type="ChEBI" id="CHEBI:49552"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotrimer.</text>
    </comment>
    <dbReference type="EC" id="1.7.2.1" evidence="3"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRL8"/>
    <dbReference type="STRING" id="1459636.NTE_01395"/>
    <dbReference type="KEGG" id="nev:NTE_01395"/>
    <dbReference type="eggNOG" id="arCOG03914">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031740_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050421">
        <property type="term" value="F:nitrite reductase (NO-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd11024">
        <property type="entry name" value="CuRO_1_2DMCO_NIR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001287">
        <property type="entry name" value="NO2-reductase_Cu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF394">
        <property type="entry name" value="FI03373P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00695">
        <property type="entry name" value="CUNO2RDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 10" id="KW-0186">Copper</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="12">
        <location>
            <begin position="116"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="11">
        <location>
            <begin position="234"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="binding site" description="type 1 copper site" evidence="10">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="type 1 copper site" evidence="10">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="type 1 copper site" evidence="10">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="type 1 copper site" evidence="10">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="type 1 copper site" evidence="10">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="type 1 copper site" evidence="10">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601287-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIF83462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="344" mass="38962" checksum="1950FA56DA4429EA" modified="2014-10-29" version="1">MLSLNNSKLLLIVVVAAAVAGTAIAFSSLGFGANAQVTDKQVTGHSLTSYTTTGDVIDPEHDNMPLKNAVVDPDKYLRQFNYGHVSKLPDGTTLREFTMVADDKRVMEVSPGVFFNVWTFNGTVPGPTIRATEGDLVRIHFINNGTRPHTMHFHGIHAAEMDGVFEKVAPGGQYTYEFTAEPFGVHLYHCHIQPLEEHISHGLYGVYIVDPKEPRPPADEMVMMMNGYDTDFDGENNFYTVNGIPFYYMHHPIQIEKDRLVRVYLVNILEFDQINNFHLHGNLFHLYRTGTSLTPDEYTDMVTMSQGERAILEFTYKYPGQYMFHAHKTEFAEKGWQGVFLVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRS1</accession>
    <name>A0A075MRS1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01453</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700276.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRS1"/>
    <dbReference type="GeneID" id="41597247"/>
    <dbReference type="KEGG" id="nev:NTE_01453"/>
    <dbReference type="eggNOG" id="arCOG05906">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113587_0_0_2"/>
    <dbReference type="OrthoDB" id="34756at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="222" mass="24830" checksum="8F520060BCC19857" modified="2014-10-29" version="1">MDLESFVADVTSLADRMAAGEPQENIQRLDFVRSRLIGLYQRNLVKINHSAMELVCAKHLIRDGYSVDVEKQLTDILVCDVYATKGDGVALVEIETGFIPPEHALDPLSYYAARIASKIARYSKHSNKFVLATPPVSILPIPNLFRRPPRDRTAEEVKEVKALCDRYYSNPPIGEEEILNAHLHMVYIINIDAGRVVEMDIDLYLEKVGEMLAKGMAGISSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRV1</accession>
    <name>A0A075MRV1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AhpC/TSA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01838</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700586.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRV1"/>
    <dbReference type="STRING" id="1459636.NTE_01838"/>
    <dbReference type="GeneID" id="41597602"/>
    <dbReference type="KEGG" id="nev:NTE_01838"/>
    <dbReference type="eggNOG" id="arCOG08717">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108778_0_0_2"/>
    <dbReference type="OrthoDB" id="6830at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050553">
        <property type="entry name" value="Thioredoxin_ResA/DsbE_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42852:SF13">
        <property type="entry name" value="PROTEIN DIPZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42852">
        <property type="entry name" value="THIOL:DISULFIDE INTERCHANGE PROTEIN DSBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="3"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="219" mass="24491" checksum="B156748BDE5F4192" modified="2014-10-29" version="1">MAVKVGTKAPNLHVSTWVQGKPTNLDQEKGNVVVVEVFQVNCPGCFMYGIPEAIELYNKYRDSGLTVLGMATAFEDYDKNTLENLQKLLTTGEVIGETQKALSMYGQLKGGKLPYKIPFPVGMDVLKKENGQITESKIMDVIEANVPDFRSYSEKDKQVMIERVKMYLQGKEYSAKTFEEYAMRGTPTSLVIDKKGNLRHNLFGATGYLGTIVEELLNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRW1</accession>
    <name>A0A075MRW1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase component</fullName>
            <ecNumber evidence="12">1.8.1.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NTE_02192</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SR1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.4" evidence="12"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226986942.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRW1"/>
    <dbReference type="STRING" id="1459636.NTE_02192"/>
    <dbReference type="GeneID" id="41597914"/>
    <dbReference type="KEGG" id="nev:NTE_02192"/>
    <dbReference type="eggNOG" id="arCOG01068">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016755_1_2_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006103">
        <property type="term" value="P:2-oxoglutarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.30:FF:000001">
        <property type="entry name" value="Dihydrolipoyl dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050151">
        <property type="entry name" value="Class-I_Pyr_Nuc-Dis_Oxidored"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22912:SF217">
        <property type="entry name" value="DIHYDROLIPOYL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22912">
        <property type="entry name" value="DISULFIDE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 9" id="KW-0274">FAD</keyword>
    <keyword evidence="3 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5 9 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="8 9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="11">
        <location>
            <begin position="13"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="10">
        <location>
            <begin position="353"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIF84246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="467" mass="50974" checksum="36863B5CF527458C" modified="2014-10-29" version="1">MAQERSKNIVEKFDLIVVGSGAGLDVANAAAQSRLKVALVEKSKMGGTCLNRGCIPSKLLIHSADVAQTIRTAEQFGIRVEKFSVDFEKIIRRTNGIIDSESDGIRSALSEIDNPRLFPVECRFVGKKEILVGQDHIITAERILLASGTRPMIPKIAGLEKGVYITSDEALRLEKQPRVLTIIGGGYIAAELAHFFGSLGTKINIIQKSDMLLTREDEEVSHKFTEILSKKYNVYLGFDTQLITRRNDKIIVSAKRSKTGEDIEIESDQLLLATGRVPNSDTLALDLAGVGTDSRGYIIVDEFLETNVKGIFALGDAVGKYQFRHSANLEAQYAFNNIISHPDKKIPVNYTAMPHAIFSSPQVAAAGYTEQELREKGAKYSKSVYPYAQTAMGEAIEDNDGFVKFLVDKNDGKILGCHILGTDASILIHEVLVSMRAGSGTIGDIQRTVHIHPALSEVVSRAADAIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRZ8</accession>
    <name>A0A075MRZ8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01884</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700619.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRZ8"/>
    <dbReference type="STRING" id="1459636.NTE_01884"/>
    <dbReference type="GeneID" id="41597640"/>
    <dbReference type="KEGG" id="nev:NTE_01884"/>
    <dbReference type="HOGENOM" id="CLU_2747967_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="70" mass="7007" checksum="055F74BC77407543" modified="2014-10-29" version="1">MNNATNNANKITASKVVAAVATGALIFGTAYGAATLHTPLGAPILTASVFSLGLLMGTTFKGKRKAEVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSC9</accession>
    <name>A0A075MSC9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ketosteroid isomerase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700712.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSC9"/>
    <dbReference type="GeneID" id="41597753"/>
    <dbReference type="KEGG" id="nev:NTE_02006"/>
    <dbReference type="HOGENOM" id="CLU_153137_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="17"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="125" mass="14076" checksum="C6CC0D5167C7D549" modified="2014-10-29" version="1">MQKNEQPAKSSKEVVISFLESLNNGDLKSARSCVSDDFTFKLPQGSFDSAEAYFKAAEQAQQAHQEPYRFDVKKVFTDGSDVCVFNDVIAGDVTLFACGWYRVEGGKIRSLKLVYDPRPLLQRKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSD1</accession>
    <name>A0A075MSD1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exo-alpha-sialidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226986965.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSD1"/>
    <dbReference type="STRING" id="1459636.NTE_02436"/>
    <dbReference type="GeneID" id="41598144"/>
    <dbReference type="KEGG" id="nev:NTE_02436"/>
    <dbReference type="eggNOG" id="arCOG02527">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_559765_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd15482">
        <property type="entry name" value="Sialidase_non-viral"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="Sialidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="477" mass="50199" checksum="87AF6E13EF7D5F77" modified="2014-10-29" version="1">MRRAALLATTIIVAAAIVAAAGLTLVFSSGSFALSNKNANLPSLSYDGSEPQTGSSDHGGSNNNRQPAVVTSNNTSSVKFRDAINLTNNPNDSVYGQVASVNDSVYVVWQESIQDLAAGSNYDVFFKSSQDNGETFNNKTLNLSRNAGFSEHPQLAASGSNVFAVWTDNTFGKKQVFFAKSSDAGKTFDEPRVLSNSGNVSSYNQEMAVFGSNVYLVWQEQAPDDGGNVIIFRASSDNGNTFADPVTVARDSSNSSGIDSRAFPKVAAYGDNVYVAWSAMESENNPRRGLYFARSADSGSAFSSAAKLSSGNEVVGEAQIAAYGDNDVYIIWGGLDAMAAKNLFYVQSSDGGGTFAGPSSVKSLKSPSNVELAVMNGRLGSGDNDNNTGNGTSETAAYSLHVAAQVPLSPDNEEIMFVSNLGGNRTSAQQQPFNLSKNSGISECPSISISGNDVFVVWEDLTVGNHEIFLAKGKVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSE6</accession>
    <name>A0A075MSE6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00187</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSE6"/>
    <dbReference type="KEGG" id="nev:NTE_00187"/>
    <dbReference type="HOGENOM" id="CLU_2504794_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="85" mass="9512" checksum="7B04309CC82BDC27" modified="2014-10-29" version="1">MVIIILIACVWPEAILFGKKSYSFYSGLDVTYLRKMNSKARATRETDKLISLGVDAEFARMLPPSARSQILKGILGLEHGKQKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSL5</accession>
    <name>A0A075MSL5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Response regulator with CheY-like receiver, AAA-type ATPase, and DNA-binding domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699343.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSL5"/>
    <dbReference type="STRING" id="1459636.NTE_00257"/>
    <dbReference type="GeneID" id="41596169"/>
    <dbReference type="KEGG" id="nev:NTE_00257"/>
    <dbReference type="eggNOG" id="arCOG06883">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_465119_0_0_2"/>
    <dbReference type="OrthoDB" id="9652at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00156">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052048">
        <property type="entry name" value="ST_Response_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040572">
        <property type="entry name" value="TackOD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43228">
        <property type="entry name" value="TWO-COMPONENT RESPONSE REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43228:SF1">
        <property type="entry name" value="TWO-COMPONENT RESPONSE REGULATOR ARR22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18551">
        <property type="entry name" value="TackOD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="1">
        <location>
            <begin position="143"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="586" mass="66259" checksum="3A03939FAF1B0A97" modified="2014-10-29" version="1">MTLSSEYKKQVLAVVDGSVGLAGGLLNERHVLEKLGQQITRIISASRIEGDEEVASFAMHVNNVVVALASGRLVPDENIRSLLRESFLEIRRSTQDNDDNNNNNNTSSNRTQIDPAIINKLKSVLTAAANTSEKDFIFLSSIDVLYIDADDFVYKSLAKRATDSMATIMKMTSIKLVSNASEARQLLFSSQEKFDVILCETDLPDESGLELIKEFSSRYPVVAISASDDPRSIQLAMKAGATDYIVKNETGIRMLPRSLHTAVVERQKRGQKTQKDEILKDPRAAKVLNYLMVSEDSVIEQTVEPSSYYKMQVLEPERDFSDTFATLERAGYVTKSSKRLALCCPRCRSANLVSYFVCANCNKSDFIKGDVIEHNRCGYNDMEFAFQKNDSKEHLFCPKCNKELKLIGVDYLRTEAAYKCKECSNIFPAPEQRFVCHDCDNSFRLSEGGWKSMYMYRLNSAKVQELNQKTLPLQSVEEYLSSKGFRISLEDYVDSKLQKFGQFDLVAYKENTIFVMIILGDDIELNHSRIIELDTMSRAVGSRVTAYAITFTDLRQVTRDLLSKFGIIVIQLKRPDQLLSKIQEYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSV5</accession>
    <name>A0A075MSV5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AAA family ATPase, CDC48 subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NTE_00352</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. CDC48 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSV5"/>
    <dbReference type="STRING" id="1459636.NTE_00352"/>
    <dbReference type="KEGG" id="nev:NTE_00352"/>
    <dbReference type="eggNOG" id="arCOG01308">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_12_2_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19519">
        <property type="entry name" value="RecA-like_CDC48_r1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19511">
        <property type="entry name" value="RecA-like_CDC48_r2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000007">
        <property type="entry name" value="AAA family ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000057">
        <property type="entry name" value="AAA family ATPase, CDC48 subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000178">
        <property type="entry name" value="CDC48/VCP homolog, AAA superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000018">
        <property type="entry name" value="Cell division control 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000012">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005938">
        <property type="entry name" value="AAA_ATPase_CDC48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004201">
        <property type="entry name" value="Cdc48_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003338">
        <property type="entry name" value="CDC4_N-term_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01243">
        <property type="entry name" value="CDC48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF171">
        <property type="entry name" value="NUCLEAR VALOSIN-CONTAINING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02933">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02359">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01073">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CDC48 N-terminal subdomain" evidence="6">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="206"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="479"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF82434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="721" mass="79043" checksum="7BBFF62728444263" modified="2014-10-29" version="1">MRVAETNAKFVGRGMALVDPKVVEELNLSAGDVLEVSAKGKKSYVLLWSSQRDDYDKKLIRIDGYTRNNIGVGIDDTVTVQKVSVKKAHQVILAPTEELNIVGLEEHLPELLEGRVVGKGDIIPLNIMGRRIGFAVTGTSPSDVASLIDSNTEFVIGSVPKSAAKGVPRVSYEDIGGLKNEVQKVREMIELPLRHPEIFERIGIEAPKGVLLHGPPGTGKTLLAKAVANETNANFYSIGGPEIMSKFYGESEERLREVFKEAEENAPSIIFIDEIDSIAPKREEVSGDVEKRVVSQLLTLMDGIKSRGKLVVIGATNRPNAIDPALRRPGRFDREIEIGIPDEQGRLDILMIHTRGMPLTEDVDLASIARVTHGFVGADLEALSKEAAMRSLRRILPEINLEQPNIPAEILNKIKVTKQDFEGALRDIQPSAMREVLIQKPNVRWEDIGGLQQVKDELAEAIEWPLKHGDLFTEADVRPPKGILLYGPPGTGKTMMAKAVATTSEANFISIKGPELISKWVGESEKGVREVFRKARQAAPCVVFFDELDSIAPRRGGESEGDARVTERVISQMLTEMDGLEDLKGVVVIGATNRPDIIDEALLRPGRFDRILEIPIPDKEARRQIFQVHTERKPIDSDVNLDKLVEMTDGMTGADIAAIVNAAAMSAIKEHVVSSSNKNEGKKAGKLKISMKHFESALDKMKVGRSITKTGAHRTFRGAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MT03</accession>
    <name>A0A075MT03_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00382</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158384962.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MT03"/>
    <dbReference type="STRING" id="1459636.NTE_00382"/>
    <dbReference type="GeneID" id="43502556"/>
    <dbReference type="KEGG" id="nev:NTE_00382"/>
    <dbReference type="HOGENOM" id="CLU_3038863_0_0_2"/>
    <dbReference type="OrthoDB" id="378959at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="54" mass="5745" checksum="3E220BBD503BA702" modified="2014-10-29" version="1">MEPVGLVSVVLGSIVLAAMATLIVVDGIKRRSMGRQAISAIDGRWKKLKVEIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MT42</accession>
    <name>A0A075MT42_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mg-chelatase subunit ChlI</fullName>
            <ecNumber evidence="2">6.6.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.6.1.1" evidence="2"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MT42"/>
    <dbReference type="STRING" id="1459636.NTE_02229"/>
    <dbReference type="GeneID" id="41597949"/>
    <dbReference type="KEGG" id="nev:NTE_02229"/>
    <dbReference type="eggNOG" id="arCOG00438">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043779_0_0_2"/>
    <dbReference type="OrthoDB" id="6798at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016851">
        <property type="term" value="F:magnesium chelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30267">
        <property type="entry name" value="PROTEIN KINASE PRKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30267:SF2">
        <property type="entry name" value="PROTEIN PRKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="1">
        <location>
            <begin position="219"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="550" mass="61177" checksum="7BBBE35D6AA28DBD" modified="2014-10-29" version="1">MSSSKIEETVHRSYTSKPKYSEIMPGVPEDYKQLKTLGDLLKINYKHVTVEEQLRGNLVAKLKAGEHPYPGIIGYDDDVVPAVNRAILSGHDVLLVGQIGQAKTKIAEAIAKNLLSPIPVVRGTVTNDIPTSMPEEHLAALLAEKEVVRTVPEFTVSRECEDIIRQDKLETKIDWLSGADRFKYILSTPDISVKDLVGQIDAIKIAKKGVELYSMESYSAGQLLQARHGILCIDELPVLDPRKQVSLLSVLQEGRFTTGAYPVVFKPDVKIIATANPIDYTHSGKIIEPLFDRLKSHVDTHYPKTVNDEMLIITQETRVADPKNVFLPVFIVKAIAKITQATRAHHDVNHDKGVSVRMAVHSMEMMIGEAERTRSIIYGIKAVPRFCDIHCIHQSSKFELAEMEDTRENRRNVLDSVIDATLKEVSLEYVDKISPDQIAKMKTEFAKNKAFQVSQVLPGGKKADTSDYESQLTKFPALKAAVAETLSAIKDEQKQLAERAKQLGIRTDSIALSDLDGEFTASVTEVVLEGLRHIQPPLLDKKDNSYALAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTB0</accession>
    <name>A0A075MTB0_9ARCH</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701016.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTB0"/>
    <dbReference type="STRING" id="1459636.NTE_02393"/>
    <dbReference type="GeneID" id="41598103"/>
    <dbReference type="KEGG" id="nev:NTE_02393"/>
    <dbReference type="eggNOG" id="arCOG03439">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_631070_0_0_2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008964">
        <property type="entry name" value="Invasin/intimin_cell_adhesion"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17957">
        <property type="entry name" value="Big_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49373">
        <property type="entry name" value="Invasin/intimin cell-adhesion fragments"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="434" mass="44742" checksum="C51B85901B5F9204" modified="2014-10-29" version="1">MALANGDKAALCSVIVAAGVVLALIAYGGPLLKDNKASNSAPASSETSSGESQEGSASNNDVQNAAAMLENTATTTTMPIAETTETGTKKEVAISDGMTLVDNVVTGPPLPDGVSVEPETATANPDSLVLDCSVPASISQDSQSGWSAILLDSSLQPVSGRTIVWQVSPGSHSFSSVTKPDGTAAPAIDLSGLAPGTYSVTAALDGNTAASCTEPFEIIQATTPVHHSSFAGDVTVPELKITAPANGQLLNGSSFGVPVRVEGTASDASNIASVEVRWTAAWGLTGYRMATPAGPDNWSNWSYDGIKFDTPGEKTILAKATDNVGNKKWKVVTFTVSFTKDKITTNPSEGAVVSSPLHVTGTATDFARGVQKVEVRTDVSGYGQAVPDTPGDWSSWSYNVTFTTSGSHQVIVRVTDNAGNTYWKTTNVIVQPGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTB5</accession>
    <name>A0A075MTB5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02398</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTB5"/>
    <dbReference type="KEGG" id="nev:NTE_02398"/>
    <dbReference type="HOGENOM" id="CLU_3210880_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="44" mass="5180" checksum="BAF0074442DDD9A5" modified="2014-10-29" version="1">MTRGGDHAHRCVYCNELYSCPLDKRDCKISWKTDHNDHYLALVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTF9</accession>
    <name>A0A075MTF9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02848</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701384.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTF9"/>
    <dbReference type="STRING" id="1459636.NTE_02848"/>
    <dbReference type="GeneID" id="41598530"/>
    <dbReference type="KEGG" id="nev:NTE_02848"/>
    <dbReference type="eggNOG" id="arCOG08811">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1105240_0_0_2"/>
    <dbReference type="OrthoDB" id="12224at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="252" mass="26166" checksum="C3216C29D787B2B1" modified="2014-10-29" version="1">MKLAVIIAGTVAVALLLAGAFTAPAFAHQRQLYTIGGKDYLIVIGSLNEPAFVDDKTGVDLRVLNADPSDPMNSRAAGATPVTGLEQTLKVEIGAGDKKKEMPLEPVFNSPGQYSAPFYPTIATTYTYHIFGTINNTPVNLTFSCTPAGEAGAQSNNSTVTVSEGVVRKGVTGGYGCFEQRTDAGFPEPYMQNNDVSKAITQLQSDVASVKAPTTATSSNNDGGNMMMAWAGVGLGIVGIAIGAVAVARRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTH5</accession>
    <name>A0A075MTH5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Formate hydrogenlyase subunit 3/multisubunit Na+/H+ antiporter, MnhD subunit</fullName>
            <ecNumber evidence="10">1.6.99.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NTE_02450</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.6.99.5" evidence="10"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTH5"/>
    <dbReference type="STRING" id="1459636.NTE_02450"/>
    <dbReference type="KEGG" id="nev:NTE_02450"/>
    <dbReference type="eggNOG" id="arCOG01537">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007100_8_1_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052175">
        <property type="entry name" value="ComplexI-like_HydComp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003918">
        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001516">
        <property type="entry name" value="Proton_antipo_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005086">
        <property type="entry name" value="PRK06521.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42682:SF3">
        <property type="entry name" value="FORMATE HYDROGENLYASE SUBUNIT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42682">
        <property type="entry name" value="HYDROGENASE-4 COMPONENT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00662">
        <property type="entry name" value="Proton_antipo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01437">
        <property type="entry name" value="NUOXDRDTASE4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="306"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="349"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="428"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="476"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="541"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="665"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="domain" description="NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal" evidence="9">
        <location>
            <begin position="68"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="NADH:quinone oxidoreductase/Mrp antiporter transmembrane" evidence="8">
        <location>
            <begin position="130"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIF84500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="684" mass="73428" checksum="6737D3F864D72D7F" modified="2014-10-29" version="1">MILFQAAALSFVLGALLPLAFRKDKNASVASFAPAALGSVLTIALAASLAISGATLEVPLPFAAAAPEIEFQFYIDGMSAFFMLIIGLVTLAVSIYSIGYSSEYYGKRSIKALGLLFNLFVLSMILVTASDNVFSFLVFWEAMSLASFFLVIYEHENESNIKSGMTYIVMTYLGTAFILGAFLALYFQTGSLSFDSFRSSEPPMPAYIRDIVFVLALVGFGTKAGLVPLHLWLPQAHPSAPSNVSALMSAVMIKMAIYGLVRVTLDFTSPSSPDSAWWGMLMVVAGSASALIGVLYAAIEKDIKRALAFSSIENIGIVILGLGLSVIFLSFDLKALAAVALLASTYHSLNHAAFKSLLFMGAGSVLFGTHTKNMEKLGGLAKKMPWTAFFFLIGAISISALPPLNGFVSEWLTMQALLSSYQVPNVILQISISFASIAFALTAGIALATFVKMFGISFLSRPRSEAAVHAKEVPKTMIAGMGVAAAMCIAFGIMPFLAAGMIASSFGLDPQFSDAMSPFSSLSVLYSAGGIESISSMSMPAVAIMMGSVAAAVVGFAVVAGSRKTARRIYSTWDCGFGELNERMEYTAASLSQPIRTVFRILYKPRMAVTKENYSDSNPYIKKSMRVESETKDVFEDRLYSPVVGATIAFFDKIRMIQTGKVNAYLLYVMVTLALLLLLARLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTI4</accession>
    <name>A0A075MTI4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02366</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700998.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTI4"/>
    <dbReference type="STRING" id="1459636.NTE_02366"/>
    <dbReference type="GeneID" id="41598082"/>
    <dbReference type="KEGG" id="nev:NTE_02366"/>
    <dbReference type="eggNOG" id="arCOG02037">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071484_0_0_2"/>
    <dbReference type="OrthoDB" id="11462at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051797">
        <property type="entry name" value="TrmB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002831">
        <property type="entry name" value="Tscrpt_reg_TrmB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34293">
        <property type="entry name" value="HTH-TYPE TRANSCRIPTIONAL REGULATOR TRMBL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34293:SF1">
        <property type="entry name" value="HTH-TYPE TRANSCRIPTIONAL REGULATOR TRMBL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01978">
        <property type="entry name" value="TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription regulator TrmB N-terminal" evidence="1">
        <location>
            <begin position="35"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="283" mass="31929" checksum="EF6A1E595266BF61" modified="2014-10-29" version="1">MEPILGQLNGFLQKFGTSTYDPSIYAMYDEVLAGLQELGLSAKEARILVYLIIRKQSTATDISRYNDIGRTETYNYITGLMRKGVVFSTFDRPQKYYALPLEKALDHLIETRRGALQRLAESKADYCSMLERLSRSMSLSSIEEKESYQILSGENSIISTVKRVILDAHEEIMLLVSEKTFASFYHTGIVDDLTALTKRGISVHLQTSCKNIQDYIGTNLEGSNIVVNSGIEEKMVDFVLIDNKDIVVMLLGASKSDKIKPHGFYTNNLPIISVFKTFFENTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTJ5</accession>
    <name>A0A075MTJ5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MEDS: MEthanogen/methylotroph, DcmR Sensory domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699551.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTJ5"/>
    <dbReference type="GeneID" id="41596405"/>
    <dbReference type="KEGG" id="nev:NTE_00533"/>
    <dbReference type="eggNOG" id="arCOG02358">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_926229_0_0_2"/>
    <dbReference type="OrthoDB" id="378988at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025847">
        <property type="entry name" value="MEDS_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14417">
        <property type="entry name" value="MEDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MEDS" evidence="1">
        <location>
            <begin position="122"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="300" mass="33827" checksum="20F67D7766BF59E9" modified="2014-10-29" version="1">MQPDLKIADTIRSTLRASLGATIYEVIALHIQSRTGIDFSHPETVVGNVRVLEDSLHQTFKDSAAPLMEKAGNKLLAAFSLPNDYNNNNFQYSQTGDLSTLVEKILKRNDPIAILHNARDRDHFTMSYTRKDEFPTLLVTFLQRGVQNNCLNVLVISEDEKRLFESFLNSSEGHHYYGKSTTGFSDDDSIVIVTHDELYGDIDSFSSSSLSSQPVVDSLNRVKQRAIQKQMSGLNIVGTFAGRLFSKGRFEECLQIENLWHHTIQQFSMPITVMCPYEKPIDEPHRTPLAICHNGGLHQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTL6</accession>
    <name>A0A075MTL6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701038.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTL6"/>
    <dbReference type="STRING" id="1459636.NTE_02418"/>
    <dbReference type="GeneID" id="41598128"/>
    <dbReference type="KEGG" id="nev:NTE_02418"/>
    <dbReference type="HOGENOM" id="CLU_1431583_0_0_2"/>
    <dbReference type="OrthoDB" id="10715at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="189" mass="20607" checksum="DA98988CB9119AB4" modified="2014-10-29" version="1">MPPAYSIIFAAVMMGFLGYTRITAAVRGSKVHKARLYGLSIFYVVFASYLTFNSFAFGIPLVYIVPYVLVFVGAEYLSNRYSGKTLSFWKTANGAVYAKGGLAIYLVYVAATGARIVISLFFVGSLTALFVYSPNTVLHDVNPAAVGLALIVSEFLLVLGAGLLVGLNRQINLHYNLITQDKETVPILW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTM4</accession>
    <name>A0A075MTM4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
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    </dbReference>
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    <dbReference type="STRING" id="1459636.NTE_02935"/>
    <dbReference type="GeneID" id="41598613"/>
    <dbReference type="KEGG" id="nev:NTE_02935"/>
    <dbReference type="eggNOG" id="arCOG08729">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2091194_0_0_2"/>
    <dbReference type="OrthoDB" id="6527at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="116" mass="13176" checksum="3F7F5C931DDAF197" modified="2014-10-29" version="1">MSDNNNPLGTFILDFQTTTFEPDAKIANDVLSGLQARCELENQYAIDPPMERAGWSFAKVFMSGQFVEKIRDRHGYEIERSKGRKFDDRFVAWLASELKKRGCGANIKLAPEMKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTQ9</accession>
    <name>A0A075MTQ9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02479</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTQ9"/>
    <dbReference type="KEGG" id="nev:NTE_02479"/>
    <dbReference type="HOGENOM" id="CLU_2257460_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="119" mass="13365" checksum="C0451A15B1D45DCD" modified="2014-10-29" version="1">MRPLDLSNRCDLLISMAQQIPSNCDPALVEIAREVCSKEGLDFESLTLHQTRGLMYYWCSTCSGTHPLTDLVILKKKKVCTHCDTPVKLYATSNKFGKLRRAIFFQHLANAITGKDSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTW3</accession>
    <name>A0A075MTW3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HEPN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385490.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTW3"/>
    <dbReference type="GeneID" id="41598235"/>
    <dbReference type="KEGG" id="nev:NTE_02536"/>
    <dbReference type="HOGENOM" id="CLU_1192585_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.330">
        <property type="entry name" value="Nucleotidyltransferases domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007842">
        <property type="entry name" value="HEPN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05168">
        <property type="entry name" value="HEPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81593">
        <property type="entry name" value="Nucleotidyltransferase substrate binding subunit/domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HEPN" evidence="1">
        <location>
            <begin position="10"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="232" mass="27429" checksum="91889DAE2370DAE7" modified="2014-10-29" version="1">MQNSDLTLTKALFKTALSDYNAAKLLWEKGFYPQCIFYLEQAFEKASKSIIAHFSVNLKKCPQEKIEKELKKSFGHNNKYSAYTVVMELLEADKWKKQQSGKWNEKQANVAFAFAEGHKKTKQNYKIEQYCNMVDYYYSKYNQFMAHPKLRHPANAILALNWALSSCFEDMENRARYPLSEHGYLNLDKLNQEKNKDCYKLLLIMVRDYINRTPDLINVANEQLPPYYNRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTW5</accession>
    <name>A0A075MTW5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">thioredoxin-dependent peroxiredoxin</fullName>
            <ecNumber evidence="2">1.11.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Thioredoxin peroxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">NTE_02586</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peroxiredoxin family. BCP/PrxQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="2"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701167.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTW5"/>
    <dbReference type="STRING" id="1459636.NTE_02586"/>
    <dbReference type="GeneID" id="41598280"/>
    <dbReference type="KEGG" id="nev:NTE_02586"/>
    <dbReference type="eggNOG" id="arCOG00310">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_14_1_2"/>
    <dbReference type="OrthoDB" id="145578at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03017">
        <property type="entry name" value="PRX_BCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000007">
        <property type="entry name" value="Thioredoxin-dependent thiol peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050924">
        <property type="entry name" value="Peroxiredoxin_BCP/PrxQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006960">
        <property type="entry name" value="PRK09437.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42801:SF4">
        <property type="entry name" value="AHPC_TSA FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42801">
        <property type="entry name" value="THIOREDOXIN-DEPENDENT PEROXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 13" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="12">
        <location>
            <begin position="4"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity" evidence="11">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIF84630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="159" mass="17560" checksum="5B9932418C4A1724" modified="2014-10-29" version="1">MSELAEGSVAPNFAMRDSSNKIFKLSDLKGKKNAVVYFYPKDFTPGCTTEAAEFTRDYQKFKDAGIEIIGISPDTEDSHDKFREKMGIPYPLVSDPEKEVAKSYGVYGKKTFMGREFMGVIRSTFLVDKSGKVLKVFGKVKPAGHSKEVLESFSSTGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MU22</accession>
    <name>A0A075MU22_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FG-GAP repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_00699</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699682.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MU22"/>
    <dbReference type="GeneID" id="41596555"/>
    <dbReference type="KEGG" id="nev:NTE_00699"/>
    <dbReference type="eggNOG" id="arCOG02562">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_496898_0_0_2"/>
    <dbReference type="OrthoDB" id="271516at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008305">
        <property type="term" value="C:integrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000413">
        <property type="entry name" value="Integrin_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23221">
        <property type="entry name" value="GLYCOSYLPHOSPHATIDYLINOSITOL PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23221:SF7">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN-SPECIFIC PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01839">
        <property type="entry name" value="FG-GAP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01185">
        <property type="entry name" value="INTEGRINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51470">
        <property type="entry name" value="FG_GAP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF82779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="557" mass="56715" checksum="5BA209664640E2C1" modified="2014-10-29" version="1">MMPYWLKNATERIQDQATNGSMGKIRWTSFFMASILVFSIALVTLHKVQADSIIDFNGDGYADMAIGVPNESISGIRGGEVNVIYGSSSGLDAAAAQADQVWNQDLGTIADSVEAGDNYGWSLAVGDFNGDGYSDLAIGIPDEDVGNATDAGAVNVIYGSASGLSDTSPIANQFWTQDSTSIADTAESGDAFGFSLAGGDFNGDGYSDLAIGVRTEDVGAVNNAGAVNVIYGSASGLSTSARVANQFWSQGSGSIADSAEDGDVFGEAVTTGDFNGDGYSDLAIGVPSEDIGAVSNGGAVNVIYGSEDGLSATSPVSNQFWNQDSTSIADTAETQDSFGTSVTAGDFNGDGYNDLAVSASGEGAVNVIYGSSSGLSATTPIANQFWHHDSGGILGIGSEGSLGAPSTTGDFNGDGYSDLALAAQGEFINFLTSSGAVNILYGSPTGLGVLHNQFWSQNSPGIEETSESGDVFGSGIAAGDFNGDGYNDLAIGIQFEDFGTVTNAGAVEVIYGSPLGLSATIKADQFWTQDSTNVEDVSETDDHFGFSLASGSTGPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MU55</accession>
    <name>A0A075MU55_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative xylanase/chitin deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_03159</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701630.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MU55"/>
    <dbReference type="STRING" id="1459636.NTE_03159"/>
    <dbReference type="GeneID" id="41598817"/>
    <dbReference type="KEGG" id="nev:NTE_03159"/>
    <dbReference type="eggNOG" id="arCOG02876">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1127116_0_0_2"/>
    <dbReference type="OrthoDB" id="8953at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10917">
        <property type="entry name" value="CE4_NodB_like_6s_7s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050248">
        <property type="entry name" value="Polysacc_deacetylase_ArnD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587:SF133">
        <property type="entry name" value="CHITIN DEACETYLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0858">Xylan degradation</keyword>
    <feature type="domain" description="NodB homology" evidence="3">
        <location>
            <begin position="37"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF85191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="246" mass="26213" checksum="5CBAE7666642FAD8" modified="2014-10-29" version="1">MKLAHLGAIATAAIVAIGVVLAIGPAYMHTLDRNKPPPVMLSFSVVDGQNVPQWCKDLSSILAKHNVKATVFVTGKVAEQNPSCVTALAAYSGIDIGSQTYSYVALPSLGDYTKALDEVKRGKMAVDAAGNVNSRIFKAPYGATDQNIYSILSSSDITADFSYPSQYNKFEGGQFVKYGLVSCDNCGESPDRVRQLMDMHSPVMIDIDNTAKTSEIESLVVALKNSNVDLVNASGLTGLDLTVRNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MU89</accession>
    <name>A0A075MU89_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="15">TIGR00269 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">NTE_02687</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">SR1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701249.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MU89"/>
    <dbReference type="STRING" id="1459636.NTE_02687"/>
    <dbReference type="GeneID" id="41598377"/>
    <dbReference type="KEGG" id="nev:NTE_02687"/>
    <dbReference type="eggNOG" id="arCOG00042">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026481_1_1_2"/>
    <dbReference type="OrthoDB" id="33422at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002144">
        <property type="term" value="C:cytosolic tRNA wobble base thiouridylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01713">
        <property type="entry name" value="CTU1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000174">
        <property type="entry name" value="ATPase, PP-loop superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056369">
        <property type="entry name" value="CTU1-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000541">
        <property type="entry name" value="Ncs6/Tuc1/Ctu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035107">
        <property type="entry name" value="tRNA_thiolation_TtcA_Ctu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054306">
        <property type="entry name" value="TtuA-like_LIM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020554">
        <property type="entry name" value="UPF0021_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00269">
        <property type="entry name" value="TIGR00269 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11807">
        <property type="entry name" value="ATPASES OF THE PP SUPERFAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11807:SF12">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22082">
        <property type="entry name" value="TtuA_LIM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004976">
        <property type="entry name" value="ATPase_YdaO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01263">
        <property type="entry name" value="UPF0021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="2-thiouridine synthetase TtuA-like N-terminal LIM" evidence="14">
        <location>
            <begin position="4"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal" evidence="13">
        <location>
            <begin position="52"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="4"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR004976-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF22082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AIF84730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="318" mass="36036" checksum="D0712A76146264D0" modified="2014-10-29" version="1">MHTCTKCHKDPSVYFRAYSGEYLCKKCFVRSIEDKTARTMSKYSMLKYGERVAVGVSGGKDSLSLLYVLKKIFDEHDRGKDDLIAVTIDEGIKGYRDESLEIVKDFCLQLGVQGKIMSYKDLFGVSMDEAMVLRPSEKKMSSCSMCGTFRRRAIDLAAESVGADVVATAHNMDDQLQTFMINLLAGDVERIGWIYPEPIEYAGGMKKIKPFVELYEHEIVFYALQREIPFQSEECPYMNESIRTDLREFFNKMEGEHPGIKNNAYASMMKVSEKLRASFTEPRGDKKCRLCGRDSTGDVCSVCKTTKSLLGQASQIDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MU91</accession>
    <name>A0A075MU91_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sec-independent protein translocase protein TatC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">tatC</name>
        <name evidence="6" type="ORF">NTE_00826</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Forms a complex with TatA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TatC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699779.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MU91"/>
    <dbReference type="STRING" id="1459636.NTE_00826"/>
    <dbReference type="GeneID" id="41596670"/>
    <dbReference type="KEGG" id="nev:NTE_00826"/>
    <dbReference type="eggNOG" id="arCOG01919">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031942_3_0_2"/>
    <dbReference type="OrthoDB" id="15305at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033281">
        <property type="term" value="C:TAT protein transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009977">
        <property type="term" value="F:proton motive force dependent protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043953">
        <property type="term" value="P:protein transport by the Tat complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00902">
        <property type="entry name" value="TatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002033">
        <property type="entry name" value="TatC"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00945">
        <property type="entry name" value="tatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30371">
        <property type="entry name" value="SEC-INDEPENDENT PROTEIN TRANSLOCASE PROTEIN TATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30371:SF0">
        <property type="entry name" value="SEC-INDEPENDENT PROTEIN TRANSLOCASE PROTEIN TATC, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00902">
        <property type="entry name" value="TatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01840">
        <property type="entry name" value="TATCFAMILY"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF82904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="271" mass="29285" checksum="24720167DB6E4860" modified="2014-10-29" version="1">MAAEMTLFEHINELRARIVRIVIAVIAISIFCMSFGLKPVEYAGIQLAYPFPDPIHNVSSQIMLYMQKSLIPTGVTLVQTAPGQAFFAQVYVSMLAGVIGAMPVVVKEIAGFIAPAISPGTRKSISHVVAPAIALFVAGVVFSYLVAVPFVLQFLYQYGEAIGAVALFNISDFISFVLQFLLGFGIAFELPVLMYGISLTGAMSPYFWRNNIRYAVIVLVVFGAIITPDGSGITMWFVAGPMIALYLAGMVAVESRAKKLEKAARLVSNNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUA7</accession>
    <name>A0A075MUA7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative RNA-binding protein, contains TRAM domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_00843</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_075055557.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUA7"/>
    <dbReference type="STRING" id="1459636.NTE_00843"/>
    <dbReference type="GeneID" id="41596686"/>
    <dbReference type="KEGG" id="nev:NTE_00843"/>
    <dbReference type="eggNOG" id="arCOG01641">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_182721_0_0_2"/>
    <dbReference type="OrthoDB" id="28569at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRAM" evidence="2">
        <location>
            <begin position="19"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF82919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="77" mass="8225" checksum="6A2C8339F678B4E9" modified="2014-10-29" version="1">MSYQRRGSGGFGGSYGPKPVETGKEYEVQITETSRKGDGIARVQGFVIFVTGGQVGQKVKVKITNVGNRFATAEIAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUC2</accession>
    <name>A0A075MUC2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">YVTN family beta-propeller repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02743</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701299.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUC2"/>
    <dbReference type="STRING" id="1459636.NTE_02743"/>
    <dbReference type="GeneID" id="41598433"/>
    <dbReference type="KEGG" id="nev:NTE_02743"/>
    <dbReference type="eggNOG" id="arCOG02562">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009318_2_0_2"/>
    <dbReference type="OrthoDB" id="9787at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051200">
        <property type="entry name" value="Host-pathogen_enzymatic-act"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019405">
        <property type="entry name" value="Lactonase_7-beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011045">
        <property type="entry name" value="N2O_reductase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011964">
        <property type="entry name" value="YVTN_b-propeller_repeat"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02276">
        <property type="entry name" value="beta_rpt_yvtn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47197:SF3">
        <property type="entry name" value="DIHYDRO-HEME D1 DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47197">
        <property type="entry name" value="PROTEIN NIRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10282">
        <property type="entry name" value="Lactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50974">
        <property type="entry name" value="Nitrous oxide reductase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="326" mass="35255" checksum="1B4F53A4FB836519" modified="2014-10-29" version="1">MKPLYLLIILAVSASFISGIGFAMLMSSSYISNEPPNHVVMADQIDNNTFIPQDNGTVFAAVNPNTNRIYVANEVSHTVSVVDGNNNKKIASIPVGAYPKIAVNPVTNRIYVTEQHMVNNIQQNGTISVIDGNNNYTKIASIEVDVNPSGIAVNPNTNKIYVTHHHIEINGKRQNGTVTVIDGNDNTKIATIQVGENPFGIAVNPNTNRIYVTNYIDGTVSVIDGNSNKVIGKPIKLDFGAEGIAVNPLANKIYVANGITATIYVIDGGDTGSKVDEIRKLFAWNVAVNPVTNKIYVPSYFFNNLSVVDGKYDNVMTVIPIGMYPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUC6</accession>
    <name>A0A075MUC6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methylase involved in ubiquinone/menaquinone biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00863</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699808.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUC6"/>
    <dbReference type="STRING" id="1459636.NTE_00863"/>
    <dbReference type="GeneID" id="41596706"/>
    <dbReference type="KEGG" id="nev:NTE_00863"/>
    <dbReference type="eggNOG" id="arCOG01779">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062440_0_1_2"/>
    <dbReference type="OrthoDB" id="1018at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="1">
        <location>
            <begin position="45"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="270" mass="30220" checksum="4EB6A405FB154804" modified="2014-10-29" version="1">MADSYVLGNRKSEIERLDIQASFFEPFSRDALLKAGIRRGMDCADVGSGSGSVTRLMAQMVGKEGHVTGVDIDDNYLQYCRTVNTFPNVDFIHQDIISSLQEKSDKFDLAFSRFMFVHLKDPKQAVKAMKGMVRDGGTVVIQELDHSPDSWLSHPHEECVDTLREAFVTLVRKSGGDPLAGRKLYKMAVEESLHASVECYAPCLMMGNEPLCSLGWRIADSLKPAILQHGVMKESEYERMFSDLKQLSKKKDSFVTYARFFSVIGKKDGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUD2</accession>
    <name>A0A075MUD2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03227</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_193354079.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUD2"/>
    <dbReference type="GeneID" id="59387798"/>
    <dbReference type="KEGG" id="nev:NTE_03227"/>
    <dbReference type="eggNOG" id="arCOG07262">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_209485_0_0_2"/>
    <dbReference type="OrthoDB" id="8919at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="55" mass="6151" checksum="3AB370130079C9F5" modified="2014-10-29" version="1">MSVPDDNSIPREIDQHLATFGKEPWEVNYDLYGYCAICNSRVDEFNYCGCGGAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUK0</accession>
    <name>A0A075MUK0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerase subunit Rpo5</fullName>
            <ecNumber evidence="2">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">DNA-directed RNA polymerase subunit H</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rpo5</name>
        <name evidence="2" type="synonym">rpoH</name>
        <name evidence="4" type="ORF">NTE_02751</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Part of the RNA polymerase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="2"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701306.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUK0"/>
    <dbReference type="STRING" id="1459636.NTE_02751"/>
    <dbReference type="GeneID" id="41598440"/>
    <dbReference type="KEGG" id="nev:NTE_02751"/>
    <dbReference type="eggNOG" id="arCOG04258">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058320_4_0_2"/>
    <dbReference type="OrthoDB" id="30537at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.20">
        <property type="entry name" value="RPB5-like RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00025">
        <property type="entry name" value="RNApol_Rpo5_RPB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014381">
        <property type="entry name" value="Arch_Rpo5/euc_Rpb5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000783">
        <property type="entry name" value="RNA_pol_subH/Rpb5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035913">
        <property type="entry name" value="RPB5-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007129">
        <property type="entry name" value="PRK09570.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10535">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10535:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01191">
        <property type="entry name" value="RNA_pol_Rpb5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55287">
        <property type="entry name" value="RPB5-like RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="2 4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNA polymerase subunit H/Rpb5 C-terminal" evidence="3">
        <location>
            <begin position="8"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF84793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="83" mass="9446" checksum="BD732CA9162DD8C8" modified="2014-10-29" version="1">MSSEKKVVKITNHVYQPKHEIIPKAEAEEVLKKYNAKPGQLPYILMSDKAIEDLDVRPGDIIKITRKSPTAGESVYYRYVVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUN4</accession>
    <name>A0A075MUN4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02882</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701410.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUN4"/>
    <dbReference type="STRING" id="1459636.NTE_02882"/>
    <dbReference type="GeneID" id="41598562"/>
    <dbReference type="KEGG" id="nev:NTE_02882"/>
    <dbReference type="HOGENOM" id="CLU_2820606_0_0_2"/>
    <dbReference type="OrthoDB" id="379182at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="66" mass="7214" checksum="10938B6C6F4E8C5A" modified="2014-10-29" version="1">MAESETMQAVMDHDHITVSIAVFGGVLVTRVFEGSGCYDQFVDFLKSQFDRGSAIRSSIIIAADSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUQ9</accession>
    <name>A0A075MUQ9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Agmatinase</fullName>
            <ecNumber evidence="5">3.5.3.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_02907</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the arginase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.11" evidence="5"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701431.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUQ9"/>
    <dbReference type="STRING" id="1459636.NTE_02907"/>
    <dbReference type="GeneID" id="41598585"/>
    <dbReference type="KEGG" id="nev:NTE_02907"/>
    <dbReference type="eggNOG" id="arCOG01700">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039478_0_2_2"/>
    <dbReference type="OrthoDB" id="7186at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008783">
        <property type="term" value="F:agmatinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033389">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via agmatine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09990">
        <property type="entry name" value="Agmatinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="ARGINASE/AGMATINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358:SF26">
        <property type="entry name" value="GUANIDINO ACID HYDROLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="341"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF84945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="382" mass="42335" checksum="E1757D3DE4329082" modified="2014-10-29" version="1">MGMEFYGDSYKGNDEPIFVGIPTFLKLPWLKSKAELEKVRPDVAIIGEPFDFGTTIRPGARYGPRAIRAASTVPSPPYEHFNIETGVDPFGVFRSVDYGDVNISPGDVVESHRRMTEKVKEVLDIDGIPVMLGGDHSITFANVRAFAKKYKNIGMIHIDTHADCAPQGLTGFKYDHGAHIRRIMELGCLKGKNYTLIGPRGYWPGPDLYKWMADQDFQWFTMLDVEELGIDKIAKEAADRANDNVDAVYISWDIDTFDPAYAPGTGEPEPNGLTSREGMRLMRLLSTSFDPDRFAFDLVEVAPNYDVSDGSSYNGGITSGLANRLIVELLAGLSLTKKGKTEGSPVRPKFYRGKGHTYDFGNGPKAKVPKRPPLAYGPKIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUS0</accession>
    <name>A0A075MUS0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03383</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701824.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUS0"/>
    <dbReference type="GeneID" id="41599029"/>
    <dbReference type="KEGG" id="nev:NTE_03383"/>
    <dbReference type="eggNOG" id="arCOG08800">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1709041_0_0_2"/>
    <dbReference type="OrthoDB" id="3105at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="153" mass="16520" checksum="ADF3F52C3B31FF0E" modified="2014-10-29" version="1">MTRLRVNVSPILLILGIVAIMLPSLSSVGVEPAMAESRASIIPSMPFLKSADQSVEVQKSVVGKQVVVWVVANNREPSDLKFAQIIEIRNSIGVTEYLAFQTGTLGANNKTEMGISWTPLYSDIYTLRTFAVSGLENPESLGPIAENSIEITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUT3</accession>
    <name>A0A075MUT3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative signal-transduction protein containing cAMP-binding and CBS domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_02927</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701448.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUT3"/>
    <dbReference type="STRING" id="1459636.NTE_02927"/>
    <dbReference type="GeneID" id="41598605"/>
    <dbReference type="KEGG" id="nev:NTE_02927"/>
    <dbReference type="eggNOG" id="arCOG00606">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG10404">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040681_12_0_2"/>
    <dbReference type="OrthoDB" id="43333at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051257">
        <property type="entry name" value="Diverse_CBS-Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43080:SF2">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43080">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN CBSX3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="4">
        <location>
            <begin position="19"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="4">
        <location>
            <begin position="84"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="169"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF84965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="207" mass="22679" checksum="89FCEF02AECC24FF" modified="2014-10-29" version="1">MSSGPDITSLLSLPIENFINMNVVIMEGDRYVDQALEKMKERGVRSVLVSHQGEVVGIVSKTDILFKVMSQGRNPGKVKLREIMTSPVLAVGPHSTVQETLAMMDKHVVRQLIVTAQSAVLGMVYRDDIFERIHLSTMSTADAALKGTPVCIINPKAIAYIKDLSAAAVVCPYCELPFDSKDALSKHIDRLHTGSGVLEGDVRRTFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUU6</accession>
    <name>A0A075MUU6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701013.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUU6"/>
    <dbReference type="GeneID" id="41598100"/>
    <dbReference type="KEGG" id="nev:NTE_02390"/>
    <dbReference type="HOGENOM" id="CLU_1665408_0_0_2"/>
    <dbReference type="OrthoDB" id="373661at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="158" mass="18080" checksum="738E62FBEEFD6EAA" modified="2014-10-29" version="1">MKSPIALTEIDRKILKSLIAPKNVRASSKTMSEQLGIPQTTLQRRRKKLEEFTSNQCFLNLSKFGWRKVEFFLSTNSGKTMDIARILLQRDEVMYVSRNIGERTIDLRVKTIVRTNAEIASLLEEIKSIEGVRDAVWTETVQVIGKKDQLPDSIISQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MV62</accession>
    <name>A0A075MV62_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Methyltransferase domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_01096</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic/archaeal PrmC-related family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699985.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MV62"/>
    <dbReference type="STRING" id="1459636.NTE_01096"/>
    <dbReference type="GeneID" id="41596912"/>
    <dbReference type="KEGG" id="nev:NTE_01096"/>
    <dbReference type="eggNOG" id="arCOG00109">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018398_6_2_2"/>
    <dbReference type="OrthoDB" id="27149at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035657">
        <property type="term" value="C:eRF1 methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052190">
        <property type="entry name" value="Euk-Arch_PrmC-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45875">
        <property type="entry name" value="METHYLTRANSFERASE N6AMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45875:SF1">
        <property type="entry name" value="METHYLTRANSFERASE N6AMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF83169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="169" mass="18387" checksum="45607AD3E5047353" modified="2014-10-29" version="1">MYVPAEDTLFLVECAKHYRGTWALEIGIGSGAVAQSLLANFTNVVGTDIDLASLGYCRGKCMMLVCCDAASALCGKFDLVVTNPPYLPGDPRVDTTIHGGPAGMETTIRFIESALPLLSEKEGRMLAIVSSLADSATLDKFVREKRLKKKVVAEKALFYERLYAIELTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MV95</accession>
    <name>A0A075MV95_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385486.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MV95"/>
    <dbReference type="GeneID" id="43502650"/>
    <dbReference type="KEGG" id="nev:NTE_02530"/>
    <dbReference type="HOGENOM" id="CLU_2216932_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="106" mass="12212" checksum="1D93A15310B6AA00" modified="2014-10-29" version="1">MVTKIQIVVFLLLWLSWHLVTEYVLGWIFDPIKEGLARIFNSTYDTTVAQCMRMTDNQDKCLQAANNTKFLVDWVVSPAFSLILTVITFFGAVDRFLRTGEYAVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVF3</accession>
    <name>A0A075MVF3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminotransferase</fullName>
            <ecNumber evidence="3">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_03114</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="3"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701593.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVF3"/>
    <dbReference type="STRING" id="1459636.NTE_03114"/>
    <dbReference type="GeneID" id="41598774"/>
    <dbReference type="KEGG" id="nev:NTE_03114"/>
    <dbReference type="eggNOG" id="arCOG04273">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_3_2_2"/>
    <dbReference type="OrthoDB" id="39225at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42885">
        <property type="entry name" value="HISTIDINOL-PHOSPHATE AMINOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42885:SF1">
        <property type="entry name" value="THREONINE-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="4">
        <location>
            <begin position="23"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF85148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="357" mass="38674" checksum="FF2B16D9AA9F22C6" modified="2014-10-29" version="1">MTIAGACSHGGVYSIADHKKVRLDFSSSVNPLGAPARAVRAIERQAGRLAPVYPDPECRDLKKSLSRYLDVDAAQIAVGNGAAEIIYWFAQAFAKKRVVIPAPTFCEYELASEKAGAEVTFVPLSSDFALDAEAVIKSAKGADAVFMCNPNNPTGLLATDAVRKVIEGVDPSTKILLDECFIELVDKPKANTLVNMVRDCENLVVLRSLTKSFGMAGLRLGYSVSSLALVQAMQARKTPWNVNGLAQAAGIAALADGSHVARARALVARERRFLHDRIKSKTEFVPLKSDANYFLIQLPEGSNSTEFRDRLLKKTGVLVRDCSTFTGMDGRHIRVAVKTHRENVALVQALEAMKLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVJ2</accession>
    <name>A0A075MVJ2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methylase involved in ubiquinone/menaquinone biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03221</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVJ2"/>
    <dbReference type="STRING" id="1459636.NTE_03221"/>
    <dbReference type="KEGG" id="nev:NTE_03221"/>
    <dbReference type="eggNOG" id="arCOG01783">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037990_2_3_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050723">
        <property type="entry name" value="CFA/CMAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43667">
        <property type="entry name" value="CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43667:SF2">
        <property type="entry name" value="FATTY ACID C-METHYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="93"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="325" mass="36073" checksum="987826607665C337" modified="2014-10-29" version="1">MYKSNDEEARLIIALLLLAFFLDIQRAFFYTMMPSLHFMSGAFDSQKFKSAQRQGWDGAAEGWKKWWKTIEESAQVVSDRLVELSRIQKGNHVLDIATGIGEPAVTIARKVGSGGKVTAIDLSTAMLAIARERAKELGLTNIIEFEEGDAESFRLPPQRFDAIVSRFGLMFLPDLPNALKTMKEALVQDGRIAAAVWSTPQRVPAFLLPLEIVMKETGTPPPPPGTPGPFSLADMNRLREIFGQEGFQDIRTESNTMNFKLPSPEKYVDFVRSTAAPLTAMMAGLPPARQQEIWNKVADASRKYSDPGNGSVNFTNEVIFVSAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVK0</accession>
    <name>A0A075MVK0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02644</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701214.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVK0"/>
    <dbReference type="STRING" id="1459636.NTE_02644"/>
    <dbReference type="GeneID" id="41598337"/>
    <dbReference type="KEGG" id="nev:NTE_02644"/>
    <dbReference type="HOGENOM" id="CLU_1040522_0_0_2"/>
    <dbReference type="OrthoDB" id="376291at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="267" mass="29475" checksum="C367B3F0A0F2B2F9" modified="2014-10-29" version="1">MIKMDMPRLLDERGYKPLKVQEKAVASAALSSLTVLGESSVRALLYHMAALAAMQERELLSNYKEFEKALWSALGSGADIILKRFDEELAKNVQATDMGPNEVLDAMKRDQPYVFMRNISAGEHVLVLYRSTQFRDRMLGAFFDSTTAQGGGGRQAKGAILSEPASLAFAQSITWRDLQEKKKAGGTSLDEKVSEWTSTLGGGKLRLARDSTWLLENNIEETAAAKFKDAALVCACDLRVGIERAAKAMESHNYVVLEDSKIVYARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVN7</accession>
    <name>A0A075MVN7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF763 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVN7"/>
    <dbReference type="STRING" id="1459636.NTE_01295"/>
    <dbReference type="KEGG" id="nev:NTE_01295"/>
    <dbReference type="eggNOG" id="arCOG04253">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061722_0_0_2"/>
    <dbReference type="OrthoDB" id="9948at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008482">
        <property type="entry name" value="DUF763"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38597">
        <property type="entry name" value="BLL3834 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38597:SF1">
        <property type="entry name" value="BLL3834 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05559">
        <property type="entry name" value="DUF763"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="390" mass="43188" checksum="554C4ED3500FC276" modified="2014-10-29" version="1">MLSLQRPKLRRTQFINLPLHTGHPPAYLMRRMARLSHAMAKVMVDSYGQQEFLRRLSDPLWFQAFGCVLGFDWHSSGVTTVVTGVLKQSLSPDVHGIAIAGGKGKKSTSAMSDIPRLAGDFGLSSAKTDSLLYASKMSAKVDSAAVQDGYSLYHHAILFDERGDWAVVQQGMNAENRMARRYHWVSDSLKQGGYVLAPHAGIICEQKTARTLDMTASGSQESQKVSLDLARGNPDNLKSSIYKLTAENTLDKWLIEGEPATTKKSTMMTGYEMPRRLDWDLFRQIYDVQPKNYEELLSMQGVGAATVRALALVSELIYGTPASWQDPVKYSFAHGGKDGVPHPVARKVYDQSIKYLEGAIDGAELEREERTTALKKLAKFSEAMFPSSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVS3</accession>
    <name>A0A075MVS3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Small-conductance mechanosensitive channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03326</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701773.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVS3"/>
    <dbReference type="STRING" id="1459636.NTE_03326"/>
    <dbReference type="GeneID" id="41598976"/>
    <dbReference type="KEGG" id="nev:NTE_03326"/>
    <dbReference type="eggNOG" id="arCOG01569">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1217619_0_0_2"/>
    <dbReference type="OrthoDB" id="11475at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_beta-dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="229" mass="25094" checksum="32CBE7D7BCE81668" modified="2014-10-29" version="1">MSGEILDYWPIFSILFSSMGISFVFKDYIADLLATVVIKKTKDIKPGTRIKVTGAGLGTTKGDVMDIGLLRTTVMEVGDGERLPSVRTGRLIKVPNYMLINNPVMVYGDTIIDEAVAYVPRPYPDTQLLIDSMKDAIVSNGHGLIEVGLYQKDDRLIIHGVFEVKTSEMGDERSKILRDFLIKSKQISPVTTEAPKVEAAVAVVQQEAAKPTAVAEKVVIPLANAERDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVU2</accession>
    <name>A0A075MVU2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PepSY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03341</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVU2"/>
    <dbReference type="STRING" id="1459636.NTE_03341"/>
    <dbReference type="KEGG" id="nev:NTE_03341"/>
    <dbReference type="HOGENOM" id="CLU_1412306_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025711">
        <property type="entry name" value="PepSY"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03413">
        <property type="entry name" value="PepSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PepSY" evidence="1">
        <location>
            <begin position="93"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="192" mass="19850" checksum="2E4B5AABF87C936F" modified="2014-10-29" version="1">MLFVIWACLIAMENDKRTFYALVLGALAVAAAVGSIASVSFASAQTSSEDTTTTTKANVVAFKGADVMFQKFSPIPDIKGSVNAGSELMSNVKVSFSDAAKTAADAANGTVMGGSLTIEQSYLVYSFRVLSGDQAKTVIVDAGNGSVLYTSEGFPADVMSEISGPGNFFAPAVKAFSVKAATTPSEEGQQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVU9</accession>
    <name>A0A075MVU9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02705</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701263.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVU9"/>
    <dbReference type="STRING" id="1459636.NTE_02705"/>
    <dbReference type="GeneID" id="41598394"/>
    <dbReference type="KEGG" id="nev:NTE_02705"/>
    <dbReference type="eggNOG" id="arCOG08790">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2032932_0_0_2"/>
    <dbReference type="OrthoDB" id="11427at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="124" mass="13244" checksum="78CF4C905BED8362" modified="2014-10-29" version="1">MESGTGAPSREEVRSDSGRSFLLDANFYGNGCFLAISEGQDRRIGAISVAISSQNNTTAAKVIPSKSDPLFVNTIAEKVASMINGICIVSFYAKTQLKLEDMKAIMGGVMHIVGAENGKQQQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MW07</accession>
    <name>A0A075MW07_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4177 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03304</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MW07"/>
    <dbReference type="STRING" id="1459636.NTE_03304"/>
    <dbReference type="KEGG" id="nev:NTE_03304"/>
    <dbReference type="HOGENOM" id="CLU_2949094_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="59" mass="6735" checksum="A26916A045C53235" modified="2014-10-29" version="1">MTYMKKWLCVQVGHHEKVGGVIQEAQKDGWNLHTYTTAGPGGTFTNQIVNHYLLFVKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MW46</accession>
    <name>A0A075MW46_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative signal-transduction protein containing cAMP-binding and CBS domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_03447</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701878.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MW46"/>
    <dbReference type="STRING" id="1459636.NTE_03447"/>
    <dbReference type="GeneID" id="41599084"/>
    <dbReference type="KEGG" id="nev:NTE_03447"/>
    <dbReference type="eggNOG" id="arCOG00601">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040681_12_1_2"/>
    <dbReference type="OrthoDB" id="65817at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051257">
        <property type="entry name" value="Diverse_CBS-Domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43080:SF2">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43080">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN CBSX3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="12"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="79"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF85475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="170" mass="18815" checksum="9DD26718E1079108" modified="2014-10-29" version="1">MTIDAIPVSSIMTKNVKTANENQSIKTAAEIMDRNNIGAVIIVEEDGGGIPSGIITERDIVKLVSSSQISFNVHLSTVMKKPMITADSMMSLKDALHTMQDKNIRRLPVMHNGKMVGILTDKDIFRAILKSPALLSNFIDASLPADYRPVYQRFSEFMLADLQHPQSSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MW88</accession>
    <name>A0A075MW88_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Universal stress family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03487</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701903.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MW88"/>
    <dbReference type="STRING" id="1459636.NTE_03487"/>
    <dbReference type="GeneID" id="41599114"/>
    <dbReference type="KEGG" id="nev:NTE_03487"/>
    <dbReference type="HOGENOM" id="CLU_2010009_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UspA" evidence="1">
        <location>
            <begin position="8"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="123" mass="13953" checksum="DD1FF3AE9C009529" modified="2014-10-29" version="1">MKTESKAKTILLPFDGSSASNRAIETVTDMVLASSEREYRIIILHVIPQVDTTPLLEEFMKREADTTGNNSGSPKADDYLQTMYKQESDAAKKELERKKGDLAWNLKSSKGYNRDFDLNWQCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWP4</accession>
    <name>A0A075MWP4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03032</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWP4"/>
    <dbReference type="STRING" id="1459636.NTE_03032"/>
    <dbReference type="KEGG" id="nev:NTE_03032"/>
    <dbReference type="HOGENOM" id="CLU_3112878_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="50" mass="5868" checksum="1B107F04F4002C2E" modified="2014-10-29" version="1">MHMAVIQKIAPCLWFDGQAEEEAAKFYMLIERGTEGNERLRTNERRGQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWS3</accession>
    <name>A0A075MWS3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hydrolase or acyltransferase of alpha/beta superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701559.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWS3"/>
    <dbReference type="STRING" id="1459636.NTE_03063"/>
    <dbReference type="GeneID" id="41598730"/>
    <dbReference type="KEGG" id="nev:NTE_03063"/>
    <dbReference type="eggNOG" id="arCOG01648">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_50_2_2"/>
    <dbReference type="OrthoDB" id="7531at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050228">
        <property type="entry name" value="Carboxylesterase_BioH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194">
        <property type="entry name" value="HYDROLASE ALPHA/BETA FOLD FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194:SF2">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN LPX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="20"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="277" mass="31408" checksum="6DBE23291835EA66" modified="2014-10-29" version="1">MNIQIQGRQLHYIEQGKGQPVIFIHGGINDYRSWQFQIGPFSKKYRVISYSRRFAYPNRQLGNVVKDNTIGDNADDLAELIRKLELAPVHLVGHSYGAFTALYCAYRNPELVKTLVLGEPPVLPFLAKSHLEDDLELLSWFRDDAQRPAMEAFEREDDEKAIRAFVDEVMGKKNAFDQIPERARMLIMDNAKTLQGELESGMPTSFTIEDAKQVSIPTLLVVGELSPRFFHRIIEILSDNMPNTEQATIPGVTHDLGRATKPDILNAKVMEFLGKHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWS5</accession>
    <name>A0A075MWS5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Plastocyanin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_03540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987070.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWS5"/>
    <dbReference type="STRING" id="1459636.NTE_03540"/>
    <dbReference type="GeneID" id="41599158"/>
    <dbReference type="KEGG" id="nev:NTE_03540"/>
    <dbReference type="eggNOG" id="arCOG02929">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1691619_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028096">
        <property type="entry name" value="EfeO_Cupredoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13473">
        <property type="entry name" value="Cupredoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="EfeO-type cupredoxin-like" evidence="2">
        <location>
            <begin position="96"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF85568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="166" mass="18438" checksum="10037BCEB25E15CB" modified="2014-10-29" version="1">MKKQKVRPKPRFTRNRAVAIGAIAAVLAIVGFFGYRALVPTNGSVPVLSFPMNDFIKATHGKSGYFYLSQTSGSVKGLRTSSSNSGSQINPNYVYSKGELVSFHFINEDYDTHSQHNFNIDEFNVHTKDLGYFGSETVSFVADKTGTFNYYCSIHPEMKGTITVEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWY4</accession>
    <name>A0A075MWY4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cobalt-precorrin-5B C(1)-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.195</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Cobalt-precorrin-6A synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">cbiD</name>
        <name evidence="7" type="ORF">NTE_01728</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Co-precorrin-5B + S-adenosyl-L-methionine = Co-precorrin-6A + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:26285"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:60063"/>
            <dbReference type="ChEBI" id="CHEBI:60064"/>
            <dbReference type="EC" id="2.1.1.195"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; adenosylcobalamin biosynthesis; cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 6/10.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CbiD family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.195" evidence="5"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWY4"/>
    <dbReference type="STRING" id="1459636.NTE_01728"/>
    <dbReference type="KEGG" id="nev:NTE_01728"/>
    <dbReference type="eggNOG" id="arCOG04383">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041273_0_0_2"/>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00227"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043780">
        <property type="term" value="F:cobalt-precorrin-5B C1-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019251">
        <property type="term" value="P:anaerobic cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2110.10">
        <property type="entry name" value="CbiD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00787">
        <property type="entry name" value="CbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002748">
        <property type="entry name" value="CbiD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036074">
        <property type="entry name" value="CbiD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00312">
        <property type="entry name" value="cbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000849">
        <property type="entry name" value="PRK00075.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35863">
        <property type="entry name" value="COBALT-PRECORRIN-5B C(1)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35863:SF1">
        <property type="entry name" value="COBALT-PRECORRIN-5B C(1)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01888">
        <property type="entry name" value="CbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026782">
        <property type="entry name" value="CbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111342">
        <property type="entry name" value="CbiD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="2 5 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="14"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF83789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="395" mass="42010" checksum="F10E924AD08AA9F2" modified="2014-10-29" version="1">MTVDDNDNAHKENDDDLELAEQEQELPAEVEEKKKKGILRTGYTTGTTATAATKAALLALVNGKPVEQVTVSLPKGRTATLEIAWTKIEGDKTTCAAIKDGGDDPDVTHGAEICSTVSLIDDNPGMIDIDGGIGVGRVTKPGLGLEMGKAAINPTPMKMLLQAVDEVAHEQLKTKGVKVVIWVPMGKELATKTDNPRLGIVGGISILGTTGIVLPYSTASFAAAIRQSLDVAIAMGADTAVLTTGGRSEDFAKTLFPDLPEHSFIQMGDFAGYSVTQCATKHIKKAIIAGFIGKLTKMAMGIKQTHVRGHHVSLDFMAGLAEQCGAPASVVAEIRQANTARHAGEIVAKNNVHGFFDLLCKKVYEQMRDHSKGQLALEIVMFDFDGKILARYSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MX08</accession>
    <name>A0A075MX08_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NTE_03150</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MX08"/>
    <dbReference type="STRING" id="1459636.NTE_03150"/>
    <dbReference type="KEGG" id="nev:NTE_03150"/>
    <dbReference type="eggNOG" id="arCOG01972">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090389_2_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000001">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45663">
        <property type="entry name" value="GEO12009P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45663:SF11">
        <property type="entry name" value="GEO12009P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Thioredoxin" evidence="5">
        <location>
            <begin position="39"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF85182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="168" mass="18185" checksum="BFE09E9ED533EB16" modified="2014-10-29" version="1">MNNNCFPPKRIIAQFENEGGVSAAGGDDELEAIKQKKMAELQKAAAERQALSSITQPVHLSDSNFAGETARYPLMLVDFWAPWCGPCRMVAPVIDQLAKEYAGRVVFGKVNVDENPIISNTFGIASIPTMMVFKAGKVVDVMIGAMPKGQLEIKLKQHLGNSGSTIYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MXD7</accession>
    <name>A0A075MXD7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Archaeal coiled-coil protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700636.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MXD7"/>
    <dbReference type="GeneID" id="41597659"/>
    <dbReference type="KEGG" id="nev:NTE_01910"/>
    <dbReference type="eggNOG" id="arCOG01159">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_999656_0_0_2"/>
    <dbReference type="OrthoDB" id="9116at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="278" mass="31701" checksum="AE105BFF4B2BC243" modified="2014-10-29" version="1">MEADGKALESLGWEDLVTLKRKVAGDLKSVTDRLVDIDRNQFRAIVTAIKTQKTALDSVTERARQVRAEVDKRNSDLLSISEKISQSKNFLSMMEARLPAEKEEELQAIVASNQALVDAKQYKGEREKGEILSKIKDASMKMEAIKAIRTIKDQYVMLTQQSADIGNAVKALNDERDALRVRTAEINVEMDKLYDAKRKLAAERNLRLAEYEDIVKHFDAINARLDEMSAMRKRQREEYGYNLPSDALFKVKETARKKLESGSKLSLDELRLLYSEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MXQ0</accession>
    <name>A0A075MXQ0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02017</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MXQ0"/>
    <dbReference type="STRING" id="1459636.NTE_02017"/>
    <dbReference type="KEGG" id="nev:NTE_02017"/>
    <dbReference type="HOGENOM" id="CLU_2581216_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="80" mass="9169" checksum="DE6BDB61441509E5" modified="2014-10-29" version="1">MPRTSFYRTGRFLYIVAQAVEKLRCNICDMTVSLAEAKEHSARKDHALRKQKLEGDLKETASRKYGHDSSVIVQWAASIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MXR7</accession>
    <name>A0A075MXR7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ParB-like nuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_03374</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701815.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MXR7"/>
    <dbReference type="STRING" id="1459636.NTE_03374"/>
    <dbReference type="GeneID" id="41599020"/>
    <dbReference type="KEGG" id="nev:NTE_03374"/>
    <dbReference type="HOGENOM" id="CLU_622035_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB_N"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="ParB/Sulfiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB-like N-terminal" evidence="2">
        <location>
            <begin position="21"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="253"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF85402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="440" mass="48301" checksum="DBBDEAAAB271AD8F" modified="2014-10-29" version="1">MASSPPSSPSWSSSSPSSKPRILPISSLRKSRVRVNLQTEQMIEAIRASVEEGRAVPGITVGHVGKAASSSSHHHYYIVDGHARVEAYQRAEIEEINIAEVLILESETDVLIEHVRRNLHSPMNPIRVAAVAALLAKAQVENPFKALGISPVMETAVNVLTHWPNDVLTKLSRVLDTNASRFSDVYALPHFFTAFEELTEKIRRGDKDAEEELRGVISYIAQYLESIGHENEFTLPTPDQVYALMRGRKQRMAASASPGATATGASPLQQAARPLSSSSSTIRNRMSKKAVAQDDDEEEDHKVGNGRDAGGEDSDVRYKAPLLMPDRNKSIIQCTHCGRPQVVDLKTGHACPLETVADGMIEVIRDGDGKKAYILGIKAMRFLGLDRPVEEISPSKYSVLATDRKSDVEHMLRSAKPISRFVVIISDSDDYSDEDDNGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MXX6</accession>
    <name>A0A075MXX6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Universal stress protein UspA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_03454</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701883.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MXX6"/>
    <dbReference type="STRING" id="1459636.NTE_03454"/>
    <dbReference type="GeneID" id="41599089"/>
    <dbReference type="KEGG" id="nev:NTE_03454"/>
    <dbReference type="eggNOG" id="arCOG02053">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049301_16_2_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00293">
        <property type="entry name" value="USP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46268">
        <property type="entry name" value="STRESS RESPONSE PROTEIN NHAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46268:SF6">
        <property type="entry name" value="UNIVERSAL STRESS PROTEIN UP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UspA" evidence="2">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF85482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="156" mass="17605" checksum="A14D92DCFEE4CF4D" modified="2014-10-29" version="1">MTKTIFVPHEDNEASAKAIKYAIEIAKGLNMEIKLVRVVPEVLDFSTMSHWNDVERKRVKKALDRYKKNVREQEAEKLQKHVSKINSKGIKASATVVEGVNAAEKIADLVRQERPYLVVIASKRLKLRGSLAKLRMLGSVARRISEESTSPVLIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MYB5</accession>
    <name>A0A075MYB5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein S25</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_02195</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS25 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MYB5"/>
    <dbReference type="STRING" id="1459636.NTE_02195"/>
    <dbReference type="KEGG" id="nev:NTE_02195"/>
    <dbReference type="eggNOG" id="arCOG04327">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_143930_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.63.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004977">
        <property type="entry name" value="Ribosomal_eS25"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03297">
        <property type="entry name" value="Ribosomal_S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF84249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="121" mass="12818" checksum="FABB82A4CC1D19F2" modified="2014-10-29" version="1">MNILKGKSITSQRDYDMGGNKNKPAAKQDKGTAVGPAGEIKPAAKEEKKKPQQKQRLAVTIDENQGMKAIQGMKAITVQSVAKAAGVKISVANSLVKTLEAKGVVKKVGGYSGHRVYAKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MYL3</accession>
    <name>A0A075MYL3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02301</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700938.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MYL3"/>
    <dbReference type="STRING" id="1459636.NTE_02301"/>
    <dbReference type="GeneID" id="41598016"/>
    <dbReference type="KEGG" id="nev:NTE_02301"/>
    <dbReference type="HOGENOM" id="CLU_1451453_0_0_2"/>
    <dbReference type="OrthoDB" id="377398at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="190" mass="19913" checksum="23F6D84B94BCC234" modified="2014-10-29" version="1">MMMRRRMATQSIVVLLCAAFVLGAAALAVPAAANTAAYAQSGMSIEVNAPILKVKPGESAVKNIVVYGTGADSMKITNITFEKGREFFRLGNALPEQATLDPATGKLKAEVPLIVTLPPEILKDAEYPFTVTAASGQSSVQADSHALVVVVTAEKPADPMSDAMVTVMYIVVAAGGVVSIIVYKRMASKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MYP0</accession>
    <name>A0A075MYP0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3-isopropylmalate dehydratase</fullName>
            <ecNumber evidence="6">4.2.1.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">NTE_02326</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="6"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700960.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MYP0"/>
    <dbReference type="STRING" id="1459636.NTE_02326"/>
    <dbReference type="GeneID" id="41598042"/>
    <dbReference type="KEGG" id="nev:NTE_02326"/>
    <dbReference type="eggNOG" id="arCOG01698">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006714_3_4_2"/>
    <dbReference type="OrthoDB" id="6900at2157"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01583">
        <property type="entry name" value="IPMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000007">
        <property type="entry name" value="3-isopropylmalate dehydratase large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01026">
        <property type="entry name" value="LeuC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004430">
        <property type="entry name" value="3-IsopropMal_deHydase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050067">
        <property type="entry name" value="IPM_dehydratase_rel_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033941">
        <property type="entry name" value="IPMI_cat"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00170">
        <property type="entry name" value="leuC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004016">
        <property type="entry name" value="PRK05478.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009116">
        <property type="entry name" value="PRK12466.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822:SF9">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="15" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="14 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="16">
        <location>
            <begin position="10"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AIF84379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="474" mass="52003" checksum="1DBB24A17090E248" modified="2014-10-29" version="1">MARQPRTIFEKIWDSHVVHQEKEGGPSLLYIDRHLVHEVTSPQAFDGLRMNHRKVRRPDLTYATMDHNVPTTARSLPIVDQVSATQIRTLADNCREFGITLFDMHSPDQGIVHVIGPELGLTIPGTTIVCGDSHTSTHGAFGAFALGIGTSEVEHVLATQTMWMDKPKTFAVNFEGRRKNKHAVTAKDMVLYLIRTIGTAGGTGSVLEYRGDAISELSMENRMTICNMSIEGGARAGLVAPDETTFDYVRDRRYAPKGEQYERAVEYWKELRTDENAKFDRSITIDTASLAPQVSWGTNPGMVLSVNESVPSPDEFAKGNENERKAAVRALEYMALVPGTPVTDIKLDRVFVGSCTNSRLEDLVEASVVVKGRKVSPSVRAMVVPGSQQVKASAEKLGLDRIFKDAGFEWRESGCSMCLGMNPDILAPGERCASTSNRNFEGRQGAGGRTHLVSPVMAAAAAIAGHFVDVREWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MYU2</accession>
    <name>A0A075MYU2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02382</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226986963.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MYU2"/>
    <dbReference type="GeneID" id="68225774"/>
    <dbReference type="KEGG" id="nev:NTE_02382"/>
    <dbReference type="HOGENOM" id="CLU_2127722_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="137" mass="15542" checksum="3D43E7F7F699D5F4" modified="2014-10-29" version="1">MPATSKVSIGWQIVFTFVPILNLWAFYRVRKLTKFVLYVIIPALAALIIIGTLFVYFTSKPLIDSSINDASDKIINGSATLPQINVEHVRPEPWPGVFRMTTLAAQVISIGLQVWSIYLVIIWSRQHNNQFDKPSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N0E9</accession>
    <name>A0A075N0E9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_02926</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N0E9"/>
    <dbReference type="STRING" id="1459636.NTE_02926"/>
    <dbReference type="KEGG" id="nev:NTE_02926"/>
    <dbReference type="eggNOG" id="arCOG00374">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_532802_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF84964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="526" mass="56035" checksum="88DEF8E11A23C4A5" modified="2014-10-29" version="1">MRDSCPWRPPIGFSIPRIFAIMTIAAILASASTGGGGVASAQVPPSSSSPSPAYTHDSIFMALFANGDALVEYDIQIANANATTTNPPGKIKIKLFGTNINELIVTDLDDRILPTKMLTSGEVEITPGNATGARISYLTPDLVNKVGRTWTFTLQAPIEVAVKMPADSVPIDYGGNVPTLSPIGSQTLLTFKAGTIHFSYLVGTLGTEDQADITIKFADAAIKQAKASYQGIMLPEEETLLANAVAAKNAGKFGDAIKLATQASDQVQRVIPDYTAAQSEISRAGAQISQASSQGRDTSRATALLDQANSEFSQGKYSEAISTATQAVAALNGGSPQQFSTTLLMIIAGVVVAGGGAGAYLFFFRKRMRKPAPASSTTTMFQDPDPNGSGAQSALEPQQQEEEGEEGREEPEETDAISTQANAPPFESARALAGIPESQTDTGLLARIVSKIIEEKPHLRPEDRDVLGFLAEKEGAAFESEVRTRFSLPKTTVWRLVKRLEREELVEIRKAGGQNLIKLRFEGRQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLB0</accession>
    <name>A0A075MLB0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_00124</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699247.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLB0"/>
    <dbReference type="STRING" id="1459636.NTE_00124"/>
    <dbReference type="GeneID" id="41596064"/>
    <dbReference type="KEGG" id="nev:NTE_00124"/>
    <dbReference type="HOGENOM" id="CLU_1754601_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF82206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="148" mass="15865" checksum="12AF1C4D0AD234BB" modified="2014-10-29" version="1">MDRKFLIGLFFGLVIATTAIYAWEAKSHIIDNPNIEGPFFLIIAILHVPVGYWAVKNNSNLAWAIMLIGTIAIIVIFGISRSDAAFLVGRDKPGGFGSLSVISKVLQAGIVAISGWAIMDNRKNGAGNTPSIVQTQKPSPANQDGRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLD4</accession>
    <name>A0A075MLD4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLD4"/>
    <dbReference type="STRING" id="1459636.NTE_00139"/>
    <dbReference type="KEGG" id="nev:NTE_00139"/>
    <dbReference type="eggNOG" id="arCOG04796">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017896_3_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004377">
        <property type="term" value="F:GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038013">
        <property type="entry name" value="ALG11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45919">
        <property type="entry name" value="GDP-MAN:MAN(3)GLCNAC(2)-PP-DOL ALPHA-1,2-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45919:SF1">
        <property type="entry name" value="GDP-MAN:MAN(3)GLCNAC(2)-PP-DOL ALPHA-1,2-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="1">
        <location>
            <begin position="234"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="428" mass="47855" checksum="0A4EAA2FE1C12BD3" modified="2014-10-29" version="1">MLMNAKIIHDDLNAGGGSEYLALSAINTLNEMGFQVDLASFTQPNVKEIKRDFGISDLAIRNVEKIDIFSLLQADKDDKSHDQAGSHSEAAAKVYGDDDRYDLVINTHGDLLPYYYHDDDEHDDNIKRTGLRKNFVTYCHFPLLPQLVDDGSYMKFINKWTSMDLAADKDPGRKILTSSRKMYDTMMQHANVVLTNSQFSRNAIEQHYNKVNPVVVYPPVDVKKFHDVFTYSGKKEENSILVLSRFSPDKQIENAVKVAGILKDKETSAKMTLAGNISEDDQQYLEKLKQMIDDSNLQDNVHIEVDVSFPRLLELMKQSKVFLHPLAGEPFGIAIVEAMSAGLIPVVPHVGGNTEFVPSEYQFHSLEEAADIIAKRALAASDSLQDRSKMGEIASRFSVGNFNKNLKSVISPLLVSAAGEEEKYAESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLK8</accession>
    <name>A0A075MLK8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158384859.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLK8"/>
    <dbReference type="STRING" id="1459636.NTE_00074"/>
    <dbReference type="GeneID" id="43502534"/>
    <dbReference type="KEGG" id="nev:NTE_00074"/>
    <dbReference type="HOGENOM" id="CLU_3148103_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="49" mass="5765" checksum="B5900CBEE5CC0824" modified="2014-10-29" version="1">MSAAESSLDFDAYWRAWLASRLAEMREKAAARARQQQEEEQEQQEEGEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLZ6</accession>
    <name>A0A075MLZ6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamate--ammonia ligase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">NTE_00424</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">SR1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 2 Mg(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 12">Belongs to the glutamine synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLZ6"/>
    <dbReference type="STRING" id="1459636.NTE_00424"/>
    <dbReference type="KEGG" id="nev:NTE_00424"/>
    <dbReference type="eggNOG" id="arCOG01909">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017290_1_2_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamine synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019740">
        <property type="term" value="P:nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004809">
        <property type="entry name" value="Gln_synth_I"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00653">
        <property type="entry name" value="GlnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43407">
        <property type="entry name" value="GLUTAMINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43407:SF1">
        <property type="entry name" value="LENGSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="27"/>
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        </location>
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        </location>
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        <location>
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        </location>
        <ligand>
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    <sequence length="488" mass="55133" checksum="837DD3826D047F1B" modified="2014-10-29" version="1">MPYKLIDGKIVPLTFTAEEVMKRLKEDKIKFIDLQFTGLFGRFHHTTMDAKMFRIEDFADGLPKVDGSSIRGFTEIHESDLIIRPDPATYATIPWIEQAPTARLICDILSGGEKRDIFPRDPRGLAKKAEKYCSQQGYDTSYWGPEVEFFVFDKLEVNTMTPYQGQSYHITSREAPWSSDNVGYALRLKDGYLPSAPGDTLMEYRNQCVDVLTNNFGIVCDAHHHEVATAGQCEIDIRFDTLVNAADSVQSYKYIVKNIAQKRSMMATMMPKPIALDNGSGMHVNVSLWNKGKNLFYDADDDYAEMSQTARYFGGGIMEHAQALASIVAPTTNSYRRLVPGYEAPVYVAWSTGNRSAIIRIPAHYKGQKFSAMKRIEFRAPDPSCNPYLAFCAIMAAGLDGIRKKRDIGDPINEDIFKMAPKRRRELGITQLPASLRQAYEALESDSAFLKPIFDDATIEKIIEHEERENVEVSVRPHPHEFALYADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
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                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
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    <sequence length="42" mass="4739" checksum="7871F33773E0BD79" modified="2014-10-29" version="1">MAQKKGAEKNMVRGKVSCVNIYKYANLFPEDNSIISDYGRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MML1</accession>
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        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    </dbReference>
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    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AIF82375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="203" mass="23909" checksum="B727FA27E47DD98C" modified="2014-10-29" version="1">MASMSRDRIIFSPLFRVEQFESKIKRGDWYLTREGKWWVKYPTEECRAIIETAYDRLPKQRKFLFFEDAKSDKAKYLQASYFMHKMAVRFKRIFSDLDKSSWLNEKTRIYALGDGLYFGGHSLHLFRHTMAQYYLAATNWSLAYVASLDGWENTEILNKCYGGIPEYIKAQIANSIHVRFDTLNLNSTSMTTTGYSMFCPSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMM2</accession>
    <name>A0A075MMM2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peptidylprolyl isomerase</fullName>
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        </recommendedName>
    </protein>
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        <name evidence="7" type="ORF">NTE_00421</name>
    </gene>
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        <dbReference type="NCBI Taxonomy" id="1459636"/>
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        </lineage>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9 10">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699461.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMM2"/>
    <dbReference type="STRING" id="1459636.NTE_00421"/>
    <dbReference type="GeneID" id="41596300"/>
    <dbReference type="KEGG" id="nev:NTE_00421"/>
    <dbReference type="eggNOG" id="arCOG07441">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090028_6_2_2"/>
    <dbReference type="OrthoDB" id="52538at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023058">
        <property type="entry name" value="PPIase_PpiC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050245">
        <property type="entry name" value="PrsA_foldase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47245:SF1">
        <property type="entry name" value="FOLDASE PROTEIN PRSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47245">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00639">
        <property type="entry name" value="Rotamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01096">
        <property type="entry name" value="PPIC_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0697">Rotamase</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="PpiC" evidence="6">
        <location>
            <begin position="2"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF82503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="92" mass="10271" checksum="A34FA73EE57C7B86" modified="2014-10-29" version="1">MSNKIKCSHILVQKQSEALAVLERLKKGESFSKLAQELSQDRGSGKRGGDLGYFAKGVMVKPFEEAAFKLEKGQLSEPVKTEFGYHIIKRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMN6</accession>
    <name>A0A075MMN6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_00446</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699481.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMN6"/>
    <dbReference type="STRING" id="1459636.NTE_00446"/>
    <dbReference type="GeneID" id="41596322"/>
    <dbReference type="KEGG" id="nev:NTE_00446"/>
    <dbReference type="eggNOG" id="arCOG01681">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097806_0_3_2"/>
    <dbReference type="OrthoDB" id="46231at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051081">
        <property type="entry name" value="HTH_MetalResp_TranReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033788">
        <property type="entry name" value="HTH_metalloreg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33154">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR, ARSR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33154:SF33">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR SDPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF82528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="101" mass="11865" checksum="462ADE8815D66D73" modified="2014-10-29" version="1">MGSPWKAVADDSRRQILVMLKEKERTPSEIATHFDFTLPALSTHLRVLKEAGLVSERKEGQNRLYSVNRAQMSEMMRFFDAFWDDQLDSLKEYVEKEAKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMP6</accession>
    <name>A0A075MMP6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF424 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00631</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699627.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMP6"/>
    <dbReference type="STRING" id="1459636.NTE_00631"/>
    <dbReference type="GeneID" id="41596494"/>
    <dbReference type="KEGG" id="nev:NTE_00631"/>
    <dbReference type="eggNOG" id="arCOG04051">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_174522_2_0_2"/>
    <dbReference type="OrthoDB" id="18015at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1860.10">
        <property type="entry name" value="uncharacterized conserved protein from methanopyrus kandleri domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007355">
        <property type="entry name" value="DUF424"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04242">
        <property type="entry name" value="DUF424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="100" mass="11163" checksum="98EC95E31D922C4B" modified="2014-10-29" version="1">MYAARTTQYQGSLMIDICDLELIGSKLEQDSLAIDLTEAYFKQEVITQEQAGELLKKCAIANLVGDKIVGQALSMKMAKEVSVKRISGVPFLMIFKFQQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMR7</accession>
    <name>A0A075MMR7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00492</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699520.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMR7"/>
    <dbReference type="STRING" id="1459636.NTE_00492"/>
    <dbReference type="GeneID" id="41596365"/>
    <dbReference type="KEGG" id="nev:NTE_00492"/>
    <dbReference type="HOGENOM" id="CLU_377112_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="862" mass="95033" checksum="FDC4D56A557CD325" modified="2014-10-29" version="1">MSESEGNKKPVTSGYTKEKLYELIPAVYRQHDAKLGKPLEDLVGIIAENVAMMEEDIGGLHDNWFIDTCDEWVTAYIADLVGARSLSASKSSSISTLEELSQRAYVANTIAYRRRKGTAFVLEQLARDVTQWGARAVEFFQLLCTTQNVNHVRLANHQAPDLRNQSRLELIETPFDTAAHTVEVRSISSNRGRYNIPNVGLFLYRLEAFPSLGTPAFKKDGKRFTFSPLGFDAPIFNSPADETSISHIAEEINVPAPISPRTLHDAPEKYYGYGKSIFLQVKYAGKVERRRIELRDVMVCSLKDWDVAGWQSPAAGDVVAIDPARGRISLPQNADEVVVSYYYGFSGKVGGGQYGRQDQTESMPQPRRFRIAQREVFVWSSVQNQATAHMMDILRNDFGIEWLDAGATFASTGRQITLTSGANRLTLSLTAGNVGALLQVNGVDKYEFFAREINGAIYVSKHEDTYGSIPEAKMWWDFSNEKQVVFEVADSLEYRAAAGDIDLDLPANSTVAIVAAANQRPILQKITVRGERGSRLVLDGLLIRSNIRVKAGDMSELVVSHCTLPPAGPSASLTVEEEKPKLLCSWDEVVSDQNQRKALAKFLKTNCAGWIPDSPPFSSDDDDSNAEKLSVTAGHNSLYIILADGEKVARVTLSEAGVLQENVYEFTVVTENGKKNMYVQEGNDDLHASFIRSITGRIDTQKTDVHLSATDSIIDAGSGVAISVHSASLQNSTVFGKTDVDRLDLASNSIFTGTITSMITQQGCVRFSYIPLEGSKTPQRYMCLPTEQNPNVVPTFTSEKYGNPGYAQLYRDVCAEIFAGADNGAEMGAFNHLFQAQRIADVKQVLNEYLRFGLEAGVFLVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMX0</accession>
    <name>A0A075MMX0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Large ribosomal subunit protein uL1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">rpl1</name>
        <name evidence="13" type="ORF">NTE_00711</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Binds directly to 23S rRNA. Probably involved in E site tRNA release.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Probably involved in E site tRNA release. Binds directly to 23S rRNA.</text>
    </comment>
    <comment type="function">
        <text evidence="11">Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 11">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11 12">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699691.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMX0"/>
    <dbReference type="STRING" id="1459636.NTE_00711"/>
    <dbReference type="GeneID" id="41596564"/>
    <dbReference type="KEGG" id="nev:NTE_00711"/>
    <dbReference type="eggNOG" id="arCOG04289">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062853_4_0_2"/>
    <dbReference type="OrthoDB" id="10382at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.790:FF:000005">
        <property type="entry name" value="50S ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01318_A">
        <property type="entry name" value="Ribosomal_uL1_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002143">
        <property type="entry name" value="Ribosomal_uL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023669">
        <property type="entry name" value="Ribosomal_uL1_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023673">
        <property type="entry name" value="Ribosomal_uL1_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003244">
        <property type="entry name" value="PRK04203.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36427">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36427:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL1M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002155">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01199">
        <property type="entry name" value="RIBOSOMAL_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0678">Repressor</keyword>
    <keyword evidence="9 11 12" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8 11 12" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="7 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6 11" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="4 11" id="KW-0820">tRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIF82791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="232" mass="25220" checksum="801E03ED79083912" modified="2014-10-29" version="1">MVSDSQIKELVKRAREGAGKRNFSQSAELTLVLKDIDVKKGFNLNETVALPHKPSRQPTICVIAAGEMGMRAKKAGVEHVMEPEELSRLGTNKREARKLVRAHDFFLSDTTQMAAVGRSLGQFLGPKGKMPTPLPYGAPVEAIANRFRGSVRVKAKNQLNASTKIGDETLSDDQLVENANAVIAAVEKKLPQGDKNIKNVMVKFTMGKGARLSALKAADKKKEATAGEKEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MN79</accession>
    <name>A0A075MN79_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_00920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699851.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MN79"/>
    <dbReference type="GeneID" id="41596755"/>
    <dbReference type="KEGG" id="nev:NTE_00920"/>
    <dbReference type="eggNOG" id="arCOG03593">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_160433_0_0_2"/>
    <dbReference type="OrthoDB" id="380640at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021527">
        <property type="entry name" value="DUF2795"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11387">
        <property type="entry name" value="DUF2795"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="29"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF82996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="128" mass="14700" checksum="DC004E07C079F96E" modified="2014-10-29" version="1">MAKEDKPEPRTIKTRTGPTEKQNNTTTRFICKVCGDTFDDQDVLRRHVDTMHEQKRTVTATEVIRKAFGGRINFPKTKAEIVKEVEENKESLPLEVVDVVRNMPDRRYNDEADFVRGIKDYTGGSIAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNC0</accession>
    <name>A0A075MNC0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA (guanine(46)-N(7))-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NTE_00971</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>guanosine(46) in tRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42708"/>
            <dbReference type="Rhea" id="RHEA-COMP:10188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10189"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74480"/>
            <dbReference type="EC" id="2.1.1.33"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.1.1.33" evidence="2"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699891.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNC0"/>
    <dbReference type="STRING" id="1459636.NTE_00971"/>
    <dbReference type="GeneID" id="41596801"/>
    <dbReference type="KEGG" id="nev:NTE_00971"/>
    <dbReference type="eggNOG" id="arCOG01787">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1425131_0_0_2"/>
    <dbReference type="OrthoDB" id="6243at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008176">
        <property type="term" value="F:tRNA (guanine(46)-N7)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003358">
        <property type="entry name" value="tRNA_(Gua-N-7)_MeTrfase_Trmb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02390">
        <property type="entry name" value="Methyltransf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF83046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="190" mass="21584" checksum="6679A92D1435E628" modified="2014-10-29" version="1">MSEDLSLVPPHTRTIVELGSGDCRLLETLAEKDPQTVYIGIELDSEQCRQAKSRVNLQNVFVMQGSFEDIVPRLPDDSVDGFIAVLPDPAFIDEKKEDKWKPLYRAVYTKLKRPGAFRLVTEITDEILQPVSNEAFDRWSIWLVSAFRSVGFKVAGMTEGAPIEYSSRCLDQFRGDPERIRIATLDFVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNG4</accession>
    <name>A0A075MNG4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNG4"/>
    <dbReference type="STRING" id="1459636.NTE_00265"/>
    <dbReference type="KEGG" id="nev:NTE_00265"/>
    <dbReference type="HOGENOM" id="CLU_1551747_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="172" mass="19097" checksum="83DE531CB8425CC3" modified="2014-10-29" version="1">MPTCSFFSPSSAIRPSPSPSPSLHRALWVIIAACKTTSSRPLFAGIGHSCRACTQILRSVRMYACTHVRMYASMYGGVAMKLCVYKGRLSWLRPAIQLHNGRKKNSRKRSPNDGYLDDLAVWAFRWEIVCVCARMYLIVYGYKWSNASVYPVATVVSSGSCNGCLSHCICSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNI8</accession>
    <name>A0A075MNI8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acetylornithine deacetylase/succinyldiaminopimelate desuccinylase-like deacylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_01048</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699947.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNI8"/>
    <dbReference type="STRING" id="1459636.NTE_01048"/>
    <dbReference type="GeneID" id="41596871"/>
    <dbReference type="KEGG" id="nev:NTE_01048"/>
    <dbReference type="eggNOG" id="arCOG01110">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029469_2_1_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051458">
        <property type="entry name" value="Cyt/Met_Dipeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005034">
        <property type="entry name" value="PRK06446.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270">
        <property type="entry name" value="BETA-ALA-HIS DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270:SF8">
        <property type="entry name" value="DI- AND TRIPEPTIDASE DUG2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="4">
        <location>
            <begin position="193"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF83121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="451" mass="49977" checksum="DDCCAC0D402104F9" modified="2014-10-29" version="1">MIDSLVDAGMNDLISDLQALIRQPSVSAKKVGLVECANLVAKMMQKAGINSEVLYLDDKTVPPIVYGEVKSKANPAAKTLLFYNHYDVQPEEPLELWEDEPFSGTVRDNKVFGRGSADDKGELVTRIKAVEYFLKETGNVPCNIKFIVEGEEEVGSVHVEQYLKKYKEKLACDGVIWEFGYVDAKDRPILSLGMKGLLYVELIATGPSRDAHSSLAVLIENPAWRLVSALKTMRDEKSGRVTIKDWYKEVKPFTKQELAVISKEPFDEGEFRSEYGIKRFVAGARGRDAKKALVGMPTCNIAGFDSGYIGEGAKTVLPAKARVKIDFRLVPGMVPEKQLARLKKHLKDHGFSDIEVNFIHGEAAARTSIYDPFVKKVDEAAREAFGSSILSVSSAGTGPMYSFVKVLKAPCISIGSTYMFARIHSPNEFARIDLLNKCTKCMVRIIEKFAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNJ1</accession>
    <name>A0A075MNJ1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_01053</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385106.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNJ1"/>
    <dbReference type="STRING" id="1459636.NTE_01053"/>
    <dbReference type="GeneID" id="41596875"/>
    <dbReference type="KEGG" id="nev:NTE_01053"/>
    <dbReference type="HOGENOM" id="CLU_102964_1_1_2"/>
    <dbReference type="OrthoDB" id="43754at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050769">
        <property type="entry name" value="NAT_camello-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13947">
        <property type="entry name" value="GNAT FAMILY N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13947:SF37">
        <property type="entry name" value="LD18367P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="6"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF83126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="168" mass="18880" checksum="BF711F802F3912D4" modified="2014-10-29" version="1">MSFQILNYHGTAEEDLEITSLLARVFVGEGYTEKSSAEKIFALAELQKRGEIMLARSPTGKLLGMVIFVLPTSPARQVAEEDEAEIHLLAVYPEARGQGVASRLIMACERRAVSSGYSKMVLSTQPTMTEAHRVYEQLGYRRNPIRDWSSKKGTDGNSKIYFVYEKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNJ3</accession>
    <name>A0A075MNJ3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699373.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNJ3"/>
    <dbReference type="STRING" id="1459636.NTE_00295"/>
    <dbReference type="GeneID" id="41596201"/>
    <dbReference type="KEGG" id="nev:NTE_00295"/>
    <dbReference type="eggNOG" id="arCOG04793">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082323_0_0_2"/>
    <dbReference type="OrthoDB" id="350054at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018547">
        <property type="entry name" value="AbiEi_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09407">
        <property type="entry name" value="AbiEi_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AbiEi antitoxin C-terminal" evidence="1">
        <location>
            <begin position="90"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="271" mass="31587" checksum="1C8169CD0D016232" modified="2014-10-29" version="1">MSTQNLNLGANELRLLFTLEKENKSIFSMKDAKEILRTSDASVWNVIYRLKKKKRIEEIERGKYLLIPAKAGYEGLWSEVPFLILPNILNEYYVGFYSALNYWGMTEQVPRVVFVATTKRRRDLEYGPNVFKFIKLAKKRFFGFEEGEIAGTKFKISSREKTVLDCLMYPKYCGGLDEAVKGIWEARNELNFDRLIEYGKKLGISVVTRRLGYALELLNIESEIADRIASNRFKGFMWLDPLGPKKVLGYSKKYGLIINRSDKELKEWMEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNT9</accession>
    <name>A0A075MNT9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Elongation factor 2</fullName>
            <shortName evidence="10">EF-2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">fusA</name>
        <name evidence="12" type="ORF">NTE_00800</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699759.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNT9"/>
    <dbReference type="STRING" id="1459636.NTE_00800"/>
    <dbReference type="GeneID" id="41596649"/>
    <dbReference type="KEGG" id="nev:NTE_00800"/>
    <dbReference type="eggNOG" id="arCOG01559">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002794_11_1_2"/>
    <dbReference type="OrthoDB" id="6290at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01681">
        <property type="entry name" value="aeEF2_snRNP_like_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16268">
        <property type="entry name" value="EF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16261">
        <property type="entry name" value="EF2_snRNP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01514">
        <property type="entry name" value="Elongation_Factor_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000009">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00054_A">
        <property type="entry name" value="EF_G_EF_2_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004543">
        <property type="entry name" value="Transl_elong_EFG/EF2_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00490">
        <property type="entry name" value="aEF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF3">
        <property type="entry name" value="ELONGATION FACTOR-LIKE GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10 12" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="11">
        <location>
            <begin position="18"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="27"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="93"/>
            <end position="97"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="147"/>
            <end position="150"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Diphthamide" evidence="10">
        <location>
            <position position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIF82878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="733" mass="80877" checksum="5D5971F079E73762" modified="2014-10-29" version="1">MPKFKSTQEILRIIGNKDQIRNFGVIAHVDHGKTTMSDSLLAASGIIAPSVAGQALALDSMKLEQNRQMTIRGANVTLLYENEGKDYVINMIDTPGHIDFTGRVTRALRAIDGVVVVSDSVEGIMTQTETVTRQALEERVRPVLYINKIDRLVKELRLDGPAMQKWLSNIIADFNRLVDLYAEPEYKEKWKVSIQGNSVAFGSAKDRWGFNFKMAQKLGVGFKDVYEAYTAEGTEKIKALAEKSPLHDAVLGMVVEHHPPPHVAQKYRIPKIWPGDLNSEIGQALLNCDEKGPAMMMVTTINVDPQAGRVATGRLYSGTIKDGDEIYLIDAKRPGKVQSVNIYMGNTREVVSVLPAGNIPALLGLDYAVSGESISTVKTATAFESIKYVSEPVVTIAVEPKHPKDLPKLVEGLRRITVEDPNLIVKINEESGETLMAGMGVLHLEIATSLLQEMGLDIVTTQPLINYRETIRAKAGPIMSKSPNKHNKIFMRVEPLPEDIVDMIRTGKLKEDMDKKEMAKILREKGWGTDESRSVVAIDSSGNMMVDETKGVQFIQESMDSIRSGFDDVIKNGPIAKEQVRGVKFVLHHFVPHEDPAHRGLAQLMPATRRAMLGSMLIADPVLLEPILGIEIKCPQEQIGVVASVLSGKRGKLLNVEQKGIIAIIQGEVPASETFDLSEVMRGGTAGKAMWTTFFKTWAPVPNSIFRNLVAETRKRKGLNPEPPGPDEFIDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MP04</accession>
    <name>A0A075MP04_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_00455</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699488.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MP04"/>
    <dbReference type="STRING" id="1459636.NTE_00455"/>
    <dbReference type="GeneID" id="41596331"/>
    <dbReference type="KEGG" id="nev:NTE_00455"/>
    <dbReference type="eggNOG" id="arCOG03363">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_150443_0_0_2"/>
    <dbReference type="OrthoDB" id="11763at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2950">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="117"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="16"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF82537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="146" mass="15696" checksum="067222409FAD507E" modified="2014-10-29" version="1">MGHDKPVATLTSHSAVESIVGALAELESDIDSMNARVDEMKKRLLAHSNEEVDKLKQQIISMANEEAKRIVDAARAEAESESAQIMKEAETSLAAIKKNIDASFDKAVESIVKTVLGQETATTEKGEKKAASPKIKKYGSDGKPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MP14</accession>
    <name>A0A075MP14_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00822</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MP14"/>
    <dbReference type="KEGG" id="nev:NTE_00822"/>
    <dbReference type="eggNOG" id="arCOG08714">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1096680_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="295" mass="30838" checksum="F293AB19582E39CF" modified="2014-10-29" version="1">MMAIRFNLKQDILCTIMSWRAMRESGYRIMFTGVFSLAIAFVIYSRLSGTSGDAPVQASQLTDLAYAILGVTAASLAAAMYGAHTIFRAEQARAAASGGGSLMSFITGAFSDGRYWRIMAISAVGYGIFFAFLSQILVYRPDVSFSERGIAVPSTDLIPCCGAPGYMPMFTAYFTDHFLLLVIPVNVILAAVVSVMVGFNVALSVYAYRLRQAVQGKTSIVGGIGAATGLFVGCPTCAGSMISAVLGLGAIGAGASTSALAPFQTVFIAASLPALALAPFLLARSIRSISMCGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MP45</accession>
    <name>A0A075MP45_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Universal stress protein UspA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_00907</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699840.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MP45"/>
    <dbReference type="STRING" id="1459636.NTE_00907"/>
    <dbReference type="GeneID" id="41596744"/>
    <dbReference type="KEGG" id="nev:NTE_00907"/>
    <dbReference type="eggNOG" id="arCOG02053">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049301_11_1_2"/>
    <dbReference type="OrthoDB" id="105697at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00293">
        <property type="entry name" value="USP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46268">
        <property type="entry name" value="STRESS RESPONSE PROTEIN NHAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46268:SF6">
        <property type="entry name" value="UNIVERSAL STRESS PROTEIN UP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UspA" evidence="2">
        <location>
            <begin position="7"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF82983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="151" mass="17217" checksum="9CBEF974B84D29BE" modified="2014-10-29" version="1">MVEISRFKKILTPVDGSKESLRAVDVAISIARKYDSWLTALYIVHIPFGENRSSYPRTMWYKEFADDVKEDTRKWFEEIQKKGKENKLEIEMKMTETIKSVPSEIVRFAEVDKTDLIVIGSRGRSGVKKLLLGSVASGVLTYAPCPVMVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MP58</accession>
    <name>A0A075MP58_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00917</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699849.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MP58"/>
    <dbReference type="GeneID" id="41596753"/>
    <dbReference type="KEGG" id="nev:NTE_00917"/>
    <dbReference type="HOGENOM" id="CLU_1821079_0_0_2"/>
    <dbReference type="OrthoDB" id="373232at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="142" mass="15158" checksum="D18C546BD0153428" modified="2014-10-29" version="1">MARGSTTGGRKTNGIVIKAKVTSSRILEIGQNGVKTEFSDKGTMSGKYRGVHWDTVETQMNIDGTSSWRVKFIQMTNKGDMLVGEGEGTGEAPNSKGVAKLKGEGTIMTASEKLAELNGKKWVCEVDNNIAAGSATVRVTFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MP86</accession>
    <name>A0A075MP86_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MP86"/>
    <dbReference type="KEGG" id="nev:NTE_01287"/>
    <dbReference type="HOGENOM" id="CLU_2985485_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="57" mass="5841" checksum="9BD5AAE8D3630ED5" modified="2014-10-29" version="1">MPGAARAGIALLIVGALIVGLGTYYDRGAVSLYGLGMVAGGFVLYLGSSIRAKRRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPM7</accession>
    <name>A0A075MPM7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01452</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPM7"/>
    <dbReference type="KEGG" id="nev:NTE_01452"/>
    <dbReference type="HOGENOM" id="CLU_184935_0_0_2"/>
    <dbReference type="OrthoDB" id="373025at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="88" mass="9849" checksum="7FDE2DE0F6BBF639" modified="2014-10-29" version="1">MAMCAHHEKPEGGYHMTAVAACILVMGISLAIVILLWAWFGHIGPKFSDEVMRQQQETLRAQYGFEPLPKITEEDAKIPPSLRNLNSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPQ4</accession>
    <name>A0A075MPQ4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NTE_00749</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the transposase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_338031180.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPQ4"/>
    <dbReference type="STRING" id="1459636.NTE_00749"/>
    <dbReference type="GeneID" id="41596601"/>
    <dbReference type="KEGG" id="nev:NTE_00749"/>
    <dbReference type="eggNOG" id="arCOG00684">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032903_0_1_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Cas12f1-like_TNB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051399">
        <property type="entry name" value="RNA-guided_DNA_endo/Transpos"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021027">
        <property type="entry name" value="Transposase_put_HTH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040570">
        <property type="entry name" value="guided_TnpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30405:SF25">
        <property type="entry name" value="RNA-GUIDED DNA ENDONUCLEASE INSQ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30405">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="Cas12f1-like_TNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12323">
        <property type="entry name" value="HTH_OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0815">Transposition</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Transposase putative helix-turn-helix" evidence="10">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Probable transposase IS891/IS1136/IS1341" evidence="8">
        <location>
            <begin position="171"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Cas12f1-like TNB" evidence="9">
        <location>
            <begin position="284"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIF82827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="387" mass="45342" checksum="7FB1E54DA7EC5273" modified="2014-10-29" version="1">MMRNYKFRLYPTFQQESKLVNALQTCNWVYNRLIQLKPYSRNELNYALTELKETEPWLYNYHSKMLQMISTRITAEHNSLKALRKKGCKVGSFASIERASYNSFTYNQSGFKIEKRGKTDLLWLSKIGCTEIRLHRKLADIKQVTVFRRNEKWYAIITCDIAKSTFCFIDPRKSVGIDLGITKFAHDSNNRIVDNPLFLTSMAKPLRRAQRQLSRREKGGHNYQKAKSRVARLHERIRNKRQDFLHKESYHYSKEYDLIFVERLHTCNLARNRHTAKRILDSGWSTFRQFLAYKGKMVMEIDPYNTTVDCSQCGNKVQKDLAVRIHCCDRCGLVIDRDYNASLNILQKGLLQLPQGLREVTPVEILCGSMKQEMLTGCDGKYPHVII</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPR6</accession>
    <name>A0A075MPR6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Response regulator with CheY-like receiver, AAA-type ATPase, and DNA-binding domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_01493</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPR6"/>
    <dbReference type="STRING" id="1459636.NTE_01493"/>
    <dbReference type="KEGG" id="nev:NTE_01493"/>
    <dbReference type="eggNOG" id="arCOG02391">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG07810">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_643414_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009190">
        <property type="term" value="P:cyclic nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050595">
        <property type="entry name" value="Bact_response_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44591:SF25">
        <property type="entry name" value="CHEMOTAXIS TWO-COMPONENT RESPONSE REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44591">
        <property type="entry name" value="STRESS RESPONSE REGULATOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="3">
        <location>
            <begin position="60"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="302"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF83556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="426" mass="47865" checksum="31A192E582BD97DE" modified="2014-10-29" version="1">MLADSIDAFTFRTNTAKLNRDSNIFDGNDFGQRKMQDAESELRSSFGDDEISFLFSCNYCVCFVDIIGSTRITAGIDDPNRIRQYYSMFFSKIGQIARRFDARIIKIAGDCLICYFPKTADPANNSAFKDVLECGCAMIAAHDGINFELNVMNLPSLEYRISADYGRVEIAKSATSRTEDLFGSTMNLCAKINRMAAQNGMVIGGDLYQIVKAFSFNDFSFEDIGGYDIGLKHFYPVYSVIAKKRDNISGSGRDSIIPPSPRQTMHGSEILRRLHFAKNNNNNNSPSKPIIAAAGHTSNSTNVMVVDDEQDMLLTFKEFLRLEGHRAEVFVNPQEALKRYREVNPSYYGLIILDIRMPGMNGLQLYQRLKAINSNINVLFISALDAADELCSIFSGILPHNVIRKPVLREQFIHRVELCLAGHEQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPV0</accession>
    <name>A0A075MPV0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01528</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPV0"/>
    <dbReference type="STRING" id="1459636.NTE_01528"/>
    <dbReference type="KEGG" id="nev:NTE_01528"/>
    <dbReference type="HOGENOM" id="CLU_1754603_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="148" mass="16584" checksum="305444A18F84CE2D" modified="2014-10-29" version="1">MFLDGSALFAYPEPDLSFERFRGSVIIFQKYLAQSNYADSEFSLASITFIVVSFGGNTLTTATSITYFSRVAAVLANENRMGITNLAMAARMNHKRCLSIVLLMERCGYVRLVSDGRKKEVIVTERGLDYFKQFVSLVLPITSIIVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPV1</accession>
    <name>A0A075MPV1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00804</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPV1"/>
    <dbReference type="STRING" id="1459636.NTE_00804"/>
    <dbReference type="KEGG" id="nev:NTE_00804"/>
    <dbReference type="HOGENOM" id="CLU_2025193_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="8"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="122" mass="14097" checksum="958AF9BCC3EC36FC" modified="2014-10-29" version="1">MESSRIHFRAEFTIEEGKIEEYKQLVQEMSRVVEANEPDTIDYQFYLNRDETKCIVHETYANSEAALAHNTGVASQTILPKISKVARISRFDVYGNPSDELRKVLASFSPQIYNRFAGFSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQA5</accession>
    <name>A0A075MQA5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ParB-like partition protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_01182</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700050.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQA5"/>
    <dbReference type="STRING" id="1459636.NTE_01182"/>
    <dbReference type="GeneID" id="41596992"/>
    <dbReference type="KEGG" id="nev:NTE_01182"/>
    <dbReference type="eggNOG" id="arCOG11113">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059496_0_0_2"/>
    <dbReference type="OrthoDB" id="2346at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2830">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1530.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050336">
        <property type="entry name" value="Chromosome_partition/occlusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004437">
        <property type="entry name" value="ParB/RepB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00180">
        <property type="entry name" value="parB_part"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33375">
        <property type="entry name" value="CHROMOSOME-PARTITIONING PROTEIN PARB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33375:SF1">
        <property type="entry name" value="CHROMOSOME-PARTITIONING PROTEIN PARB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109709">
        <property type="entry name" value="KorB DNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="ParB/Sulfiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB-like N-terminal" evidence="2">
        <location>
            <begin position="12"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF83255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="390" mass="44360" checksum="D5ACBB9120C0AFA5" modified="2014-10-29" version="1">MQAEERHQSQLLYVYVDSIQPPSFELRSDIEQANDPAFQELCNSVRETGVIEPLIVKPVENGRFELIAGGRRLRAAMLAGLKEVPVIVKPALSDIDAKVLAIAENLHRKDLSPIEKSRALIALYESAGYSAELSLKYLMRLDEDHYRGEAKRADAIVVPEHFKEIEKKLGLAANRQWQLLKFAVLDDDVLNYAKQKGLNGNKILMLTAKGIVEKGSDAHKRIIDHICNLREYEAREYIHRCLISTGRPKKQEESNPQPFEQQSAPSAEKQKEEEEEVVNTSRSERRYARLAHCDNDDKDSSRPASELAYLSVYDLCLPAEFLSLLKRRATIAGKFDLGQYLTYVLLYKLQRSNGSRRLSLPPAERAWFMSKNKGCATVRTEKEKMREGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQB8</accession>
    <name>A0A075MQB8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700440.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQB8"/>
    <dbReference type="STRING" id="1459636.NTE_01660"/>
    <dbReference type="GeneID" id="41597435"/>
    <dbReference type="KEGG" id="nev:NTE_01660"/>
    <dbReference type="eggNOG" id="arCOG07192">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_180512_0_0_2"/>
    <dbReference type="OrthoDB" id="6229at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="75" mass="8530" checksum="E16DE5F2960DAA94" modified="2014-10-29" version="1">MKYPLRNLIYEKVRQAGNMTDADLMNALSKEGITIADAEFNKILLDLEIYGLIRVAWITKEKRRIELVADSGTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQF4</accession>
    <name>A0A075MQF4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQF4"/>
    <dbReference type="STRING" id="1459636.NTE_01375"/>
    <dbReference type="KEGG" id="nev:NTE_01375"/>
    <dbReference type="HOGENOM" id="CLU_2284912_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="101" mass="10768" checksum="EBB30ACF63162DBD" modified="2014-10-29" version="1">MHPQKVAAGIAIIVGVIGIPFPVWQMVAHGCSPSQVYSHRDFAPNEGPPGTCDMALQNASGYFVAVVALGSLGSFLLVLGMEERSFLTLKKIPKENDNAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQF7</accession>
    <name>A0A075MQF7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Putative pterin-4-alpha-carbinolamine dehydratase</fullName>
            <shortName evidence="4">PHS</shortName>
            <ecNumber evidence="4">4.2.1.96</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">4-alpha-hydroxy-tetrahydropterin dehydratase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Pterin carbinolamine dehydratase</fullName>
            <shortName evidence="4">PCD</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_01038</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin = (6R)-L-erythro-6,7-dihydrobiopterin + H2O</text>
            <dbReference type="Rhea" id="RHEA:11920"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15642"/>
            <dbReference type="ChEBI" id="CHEBI:43120"/>
            <dbReference type="EC" id="4.2.1.96"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the pterin-4-alpha-carbinolamine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.96" evidence="4"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699939.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQF7"/>
    <dbReference type="STRING" id="1459636.NTE_01038"/>
    <dbReference type="GeneID" id="41596861"/>
    <dbReference type="KEGG" id="nev:NTE_01038"/>
    <dbReference type="eggNOG" id="arCOG02939">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081974_3_2_2"/>
    <dbReference type="OrthoDB" id="10495at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008124">
        <property type="term" value="F:4-alpha-hydroxytetrahydrobiopterin dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.20">
        <property type="entry name" value="Transcriptional coactivator/pterin dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00434">
        <property type="entry name" value="Pterin_4_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036428">
        <property type="entry name" value="PCD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001533">
        <property type="entry name" value="Pterin_deHydtase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002017">
        <property type="entry name" value="PRK00823.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002018">
        <property type="entry name" value="PRK00823.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12599">
        <property type="entry name" value="PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12599:SF0">
        <property type="entry name" value="PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01329">
        <property type="entry name" value="Pterin_4a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55248">
        <property type="entry name" value="PCD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF83112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="100" mass="11672" checksum="6C4ADCAA741B1FA0" modified="2014-10-29" version="1">MHDEDYRELSKQELDKALEKMPGWKIADGKLRRSFEFGDFAEAFAFMTRVAIEAEKLNHHPEWSNVYNHVTINLVTHDIGNKVSNYDVILAQKISEIHKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQK7</accession>
    <name>A0A075MQK7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699971.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQK7"/>
    <dbReference type="STRING" id="1459636.NTE_01079"/>
    <dbReference type="GeneID" id="41596896"/>
    <dbReference type="KEGG" id="nev:NTE_01079"/>
    <dbReference type="HOGENOM" id="CLU_1801611_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="143" mass="15564" checksum="9F4D5772C1D93DC6" modified="2014-10-29" version="1">MKNAPVVAGIVVGAGAVLATIAVIMFAPIPEPVALGSRHPTIEVRDLHDTYNAGEEIHFVVDTQGECTKPGVVIKDTATNQTVMETRPYPIHCPYSDDPAFPHLAWNSTDVAGDQMITIDKQGRYSLTVILFEKQDSWQFTVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQM7</accession>
    <name>A0A075MQM7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01322</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700170.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQM7"/>
    <dbReference type="GeneID" id="41597123"/>
    <dbReference type="KEGG" id="nev:NTE_01322"/>
    <dbReference type="HOGENOM" id="CLU_1665408_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043200">
        <property type="term" value="P:response to amino acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30154">
        <property type="entry name" value="LEUCINE-RESPONSIVE REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30154:SF34">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR AZLB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13412">
        <property type="entry name" value="HTH_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="157" mass="17924" checksum="0C64EBE421FCDD49" modified="2014-10-29" version="1">MKLCALDREILKIILAPHNGKIISSKEIAKRLSVPATTVQRHRRKLEDEEILTASYCLNLKRFGLRHVDFLVSTQNGKTMLVIKKLEKMKEVVSVTRSIGQPTIDLQVETILMDNEEILNMLETIKGMDGVRDAIWSESIQRVVQKAAVPYHLLDYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQQ0</accession>
    <name>A0A075MQQ0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01474</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQQ0"/>
    <dbReference type="STRING" id="1459636.NTE_01474"/>
    <dbReference type="KEGG" id="nev:NTE_01474"/>
    <dbReference type="HOGENOM" id="CLU_3371267_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="34" mass="4080" checksum="9C488DB23D337FBF" modified="2014-10-29" version="1">MARHENNKTHAYSAQRSGSKKYAKAERRKRHKPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQV4</accession>
    <name>A0A075MQV4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQV4"/>
    <dbReference type="STRING" id="1459636.NTE_01525"/>
    <dbReference type="KEGG" id="nev:NTE_01525"/>
    <dbReference type="eggNOG" id="arCOG04362">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1521800_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="176" mass="19948" checksum="84A13513604453FF" modified="2014-10-29" version="1">MAVVVVAFTKKPTGFSMRREDSLSWSLKVKNWSYAQLAMQDSELLIASTFKVLGDKMACNLLVASASDTGVHPIAAMKKMALTRKQFYSRLARLKKLKLIKKMGENYVPTLQGLLVVNNLLPMMREIIESRWKIDSIDKLMTDKEFTNSHVEEIIDTLLRGSALRKEVLSILQKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQW6</accession>
    <name>A0A075MQW6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00284</name>
        <name evidence="2" type="ORF">NTE_01144</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQW6"/>
    <dbReference type="STRING" id="1459636.NTE_00284"/>
    <dbReference type="KEGG" id="nev:NTE_00284"/>
    <dbReference type="KEGG" id="nev:NTE_01144"/>
    <dbReference type="HOGENOM" id="CLU_3075136_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="52" mass="6196" checksum="356C17C86BAC475A" modified="2014-10-29" version="1">MIVSPRHIHESTIVGFRLFSAIFRENHLFKTKKSKYWRHIGIGVGRKTWTDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQZ5</accession>
    <name>A0A075MQZ5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Arabinose efflux permease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NTE_01164</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700034.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQZ5"/>
    <dbReference type="STRING" id="1459636.NTE_01164"/>
    <dbReference type="GeneID" id="41596976"/>
    <dbReference type="KEGG" id="nev:NTE_01164"/>
    <dbReference type="eggNOG" id="arCOG00144">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG11894">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_34_0_2"/>
    <dbReference type="OrthoDB" id="117970at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17504">
        <property type="entry name" value="MFS_MMR_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF192">
        <property type="entry name" value="TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="328"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="409"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="441"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="466"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="502"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="559"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="47"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="242"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="653"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="653"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="672"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF83237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="736" mass="79291" checksum="7FB0C67ABD531406" modified="2014-10-29" version="1">MPPSQNGNKNDDDNNDHKNNNNNNAPSNSSSTRPPPATKIPRRAWEVTAILSSVATMTMYAETMLIPAIPGLIKDFDISYSTSSWILATYLVSAAVMTPISGKLSDIYGKKKVLLAIMIIYTASASLGGFANSISFLLAVRALQGIGLSMFPIAFSMARDQFPRQKVAIGQGIISSMYASGAVIGLAVGSSIIQQYGWQATYHSLIPVAAILTIVIWRFIRTEDEYNLIPLQELQRKQIGTTTSSAENTGLADNDDYSSGSNRGRRRRQQRYGGDGDDDDKNKRKTNNAVEIATEKNVRLDVKGAITLALTITSFLLAITFTEPGSVPAAYALILIAVFLALGTTSLVLFVIFEKRVRSPLLDLSLFLNKTMLQANILIFTLGFSMFTVFQTIPVLVENPKPVGFGGNAISAAMVQLPFAIILLVFGPTSGFIISKIGSRIPIIAGTSISTLGFFLLYLLHSTELLVSAALAILAVGISLTNVGAVNVVILSTPRQNSGISLGMAMLLRIIGSAIGPVVAAMFMDLYSYSAAISAATPEASATTAAIQANYPSAESYNLIYLTCTLLALFSLGFAIMLARKSPKCQNHLPKERGEMQGAIAEAIKCEILSWPGVTSRPHGFGGVEFRVGTKEMGHLHGQNMVDLPLSPSAAAAAQAASGGNNNNSYGNKLVEPPRELESNKREEEKSSSLSPSLLPLHDVYPESKWINYWIKDKKDVPQVISLFRLQYDRLTKAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQZ7</accession>
    <name>A0A075MQZ7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01917</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQZ7"/>
    <dbReference type="STRING" id="1459636.NTE_01917"/>
    <dbReference type="KEGG" id="nev:NTE_01917"/>
    <dbReference type="HOGENOM" id="CLU_2874902_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="63" mass="7057" checksum="BC27CCD556301C81" modified="2014-10-29" version="1">MKELILALFIASSTCAAISASSINYTGSSVCISLRIHLNPSKMTTLFERSKIFLQFLYRNIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MR64</accession>
    <name>A0A075MR64_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amidophosphoribosyltransferase</fullName>
            <shortName evidence="7">ATase</shortName>
            <ecNumber evidence="7">2.4.2.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glutamine phosphoribosylpyrophosphate amidotransferase</fullName>
            <shortName evidence="7">GPATase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">purF</name>
        <name evidence="13" type="ORF">NTE_01993</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>5-phospho-beta-D-ribosylamine + L-glutamate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + L-glutamine + H2O</text>
            <dbReference type="Rhea" id="RHEA:14905"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="EC" id="2.4.2.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="7 10">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7 11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="7 11">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 7 8">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.14" evidence="7"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700701.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MR64"/>
    <dbReference type="STRING" id="1459636.NTE_01993"/>
    <dbReference type="GeneID" id="41597740"/>
    <dbReference type="KEGG" id="nev:NTE_01993"/>
    <dbReference type="eggNOG" id="arCOG00093">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022389_3_3_2"/>
    <dbReference type="OrthoDB" id="5976at2157"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004044">
        <property type="term" value="F:amidophosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01931">
        <property type="entry name" value="PurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005854">
        <property type="entry name" value="PurF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01134">
        <property type="entry name" value="purF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11907">
        <property type="entry name" value="AMIDOPHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13522">
        <property type="entry name" value="GATase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000485">
        <property type="entry name" value="Amd_phspho_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6 7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3 7 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 11" id="KW-0408">Iron</keyword>
    <keyword evidence="7 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="12">
        <location>
            <begin position="6"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7 9">
        <location>
            <position position="6"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 11">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 11">
        <location>
            <position position="392"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 11">
        <location>
            <position position="452"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 11">
        <location>
            <position position="455"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIF84051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="478" mass="51974" checksum="C400ECC4C4AB03C0" modified="2014-10-29" version="1">MVHENCGVVGIFSLAGHNVIPFAVDMLRALQHRGQEAWGIAIPNKPPFKRLGLVSQAAPDFQTIVRKYKSSAAIGHVRYSTFGKSNLENAQPLKVKDLCIAHNGTIANVEQLSGMVGGCTFTPQTMSDTLVAAQRLVMHIAEKDDMASAMSILKSEMVGSFCFTFLTDEGSVYAARDTRGFRPLVLGFHKETSTYMVASESCALAAVGAQLVRDVEPGELVKMGKAGVESQQFATEKPHAHCAFEYTYFAHPSSIMEGINVYSARKKIGQFLAKKFPIQDADVVVPVPDSARPAALGYALESCLPFEEGLLKDRYSKKGSMRSFIEPYQTDRVEINKGIIPIREVIEGKHVVVVDDSIVRGTSSASIISTLRSAGARRISLVVTYPPIRYPCYAGIDFPSQEELIAYQHGAEEQANEKVAGKVARVIGADYVAYNDTSNLASAIGMPEEELCFTCSTGNYAPLGIKPVFKTRAQIKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MR76</accession>
    <name>A0A075MR76_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Methylase involved in ubiquinone/menaquinone biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_02009</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700715.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MR76"/>
    <dbReference type="STRING" id="1459636.NTE_02009"/>
    <dbReference type="GeneID" id="41597756"/>
    <dbReference type="KEGG" id="nev:NTE_02009"/>
    <dbReference type="eggNOG" id="arCOG01782">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1183955_0_0_2"/>
    <dbReference type="OrthoDB" id="8915at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861:SF1">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Methyltransferase" evidence="4">
        <location>
            <begin position="54"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF84066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="222" mass="24934" checksum="DD8CF5BEF8C65E10" modified="2014-10-29" version="1">MKGDNDGPSFSNIPAKSASYYDRNTQSYSESNQNPADFIDEFLEYLQKGKGKAVLDLGSGPGINAGYMHSRNFQVIGIDLSEKMIEYARSRYPHIEFRLGDMTKLPFSANSFDSILASYSLIHLTKDIIGSVLARLYEILRQGGVIYLSVQCGNSTQGFFSHPLIPSDQVFLNIFAKEEIVGLLSEHRFEIISQHEKLPHGKVFNFTKLFIIAKKTEPLQQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRE1</accession>
    <name>A0A075MRE1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative esterase of the alpha-beta hydrolase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_02065</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRE1"/>
    <dbReference type="KEGG" id="nev:NTE_02065"/>
    <dbReference type="HOGENOM" id="CLU_517426_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="3">
        <location>
            <begin position="138"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="348"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF84121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="526" mass="57565" checksum="AF0F9E60A50CAD8D" modified="2014-10-29" version="1">MIAWLFSGGDSALDKVKKDIQSLLATRSLYNLDPIHDTMLKRASFHPELVAKSGIKLRLAMVALEDGKLRYVTETGAVIERDGSPTLVTQYDPACSGPILKKIAELESQIKDAQDSAFDDKDPQKGALAGVAALRNKQAQLRKQLENCPKKQFPVMTSLVSGALASSSIPFVFPPVKVGSYWYIDGGVRATTPIESAIDAGADFIYAVVASSTEIDPQKPILGGGGPLHSYDPPANILDIGMRASADIMPSEISESSLFPPNSWGKPVVVIRPEHDIHDGMTIDPGLIRIRVAHGFMRADDVITAWDKDPATYGEQTTKNSSERNTTLIVRLRRKIWQLEYAANGFTYSSDQGKHPETPSPLTGPDSGKKRSEALASVRHWKRELKELVDQRIASGGKVPEGYEQWWLGWEQHPWKPIVALWDAQNPFVPLKTMNVSVNPQKVAVNKPVKFTVTASYNGSAVVANVLSDGKLIGTTGKLIEYKFATKTQTEFDPETKQKITEVIAPMVSVVASGYHTVYLDLFGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRG8</accession>
    <name>A0A075MRG8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">rRNA metabolism protein, SBDS family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_01339</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SDO1/SBDS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700183.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRG8"/>
    <dbReference type="STRING" id="1459636.NTE_01339"/>
    <dbReference type="GeneID" id="41597138"/>
    <dbReference type="KEGG" id="nev:NTE_01339"/>
    <dbReference type="eggNOG" id="arCOG04187">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043216_2_0_2"/>
    <dbReference type="OrthoDB" id="84504at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1250.10">
        <property type="entry name" value="Ribosome maturation protein SBDS, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.900">
        <property type="entry name" value="SBDS protein C-terminal domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036786">
        <property type="entry name" value="Ribosome_mat_SBDS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002140">
        <property type="entry name" value="Sdo1/SBDS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039100">
        <property type="entry name" value="Sdo1/SBDS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046928">
        <property type="entry name" value="SDO1/SBDS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018978">
        <property type="entry name" value="SDO1/SBDS_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037188">
        <property type="entry name" value="Sdo1/SBDS_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019783">
        <property type="entry name" value="SDO1/SBDS_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00291">
        <property type="entry name" value="RNA_SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927">
        <property type="entry name" value="RIBOSOME MATURATION PROTEIN SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927:SF4">
        <property type="entry name" value="RIBOSOME MATURATION PROTEIN SDO1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20268">
        <property type="entry name" value="SBDS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09377">
        <property type="entry name" value="SBDS_domain_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01172">
        <property type="entry name" value="SBDS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89895">
        <property type="entry name" value="FYSH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109728">
        <property type="entry name" value="Hypothetical protein AF0491, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS N-terminal" evidence="2">
        <location>
            <begin position="7"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS central" evidence="3">
        <location>
            <begin position="100"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS C-terminal" evidence="4">
        <location>
            <begin position="164"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF83407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="229" mass="25557" checksum="328F06518E2D5BCE" modified="2014-10-29" version="1">MTENKFTIVRLAVEGDKFELLVKPDPALEYKLGKRADISSVLVSDEVYSDANKGSRASSEKLMKHFKTTDSAEVARQILARGELNLTTDQRRKMVEEKRKQIVAYINRSFVDPKSHLPHPITRIEAAMEQARVSIDPHKKAEDQAKDVVDALRAILPLKSETLKLIVRVPPQYAGQSYSVIKPAGDLKSEEWQADGSLRVVIEMNAGMRGNFIDRLGSVTKGTAEVKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRK8</accession>
    <name>A0A075MRK8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cobalt-precorrin 5A acetaldehyde-lyase</fullName>
            <ecNumber evidence="4">3.7.1.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_01732</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.7.1.12" evidence="4"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987241.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRK8"/>
    <dbReference type="STRING" id="1459636.NTE_01732"/>
    <dbReference type="GeneID" id="41597501"/>
    <dbReference type="KEGG" id="nev:NTE_01732"/>
    <dbReference type="eggNOG" id="arCOG00651">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028397_0_1_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043779">
        <property type="term" value="F:cobalt-precorrin-5A acetaldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.180">
        <property type="entry name" value="CobE/GbiG C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052553">
        <property type="entry name" value="CbiG_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021745">
        <property type="entry name" value="CbiG_mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021744">
        <property type="entry name" value="CbiG_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002750">
        <property type="entry name" value="CobE/GbiG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036518">
        <property type="entry name" value="CobE/GbiG_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038029">
        <property type="entry name" value="GbiG_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37477">
        <property type="entry name" value="COBALT-PRECORRIN-5A HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37477:SF1">
        <property type="entry name" value="COBALT-PRECORRIN-5A HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01890">
        <property type="entry name" value="CbiG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11761">
        <property type="entry name" value="CbiG_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11760">
        <property type="entry name" value="CbiG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159672">
        <property type="entry name" value="CbiG N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159664">
        <property type="entry name" value="CobE/GbiG C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cobalamin synthesis G N-terminal" evidence="2">
        <location>
            <begin position="53"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Cobalamin biosynthesis central region" evidence="3">
        <location>
            <begin position="138"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="CobE/GbiG C-terminal" evidence="1">
        <location>
            <begin position="232"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF83793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="356" mass="38564" checksum="E7A0427126C16E57" modified="2014-10-29" version="1">MASKTAVVAITKHGIEIARKIKGKMPEVEVYVPAKHSDGGADINWFSEQSTQLVASLFKSHDALICVFSLGAVIRMVAPYLVDKKSDPAVIVIDDRANYVISALSGHLGGANALARLVASFLGAKPVITTAADVNETIAVDLVGREFGWTIENFDNVTKTSALMVNEERIAIYQDAGERNWWQGQQLPKNVTVVDNIEKVKSPDFKAALVITDKMVDQDVVAKSVVYRPKTLVVGIGLHWDTNKETIESGVTAVFKEKGLALKSVRNIASVDRGARVKGLDEFAGQYGMPVQIYKKEDLAKVEVPNPSPAVQKFEGTASVSEASAILDSKGELIVQKQKFPPNLTVAVCRVADFSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRQ2</accession>
    <name>A0A075MRQ2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SpoVT / AbrB-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRQ2"/>
    <dbReference type="STRING" id="1459636.NTE_01777"/>
    <dbReference type="KEGG" id="nev:NTE_01777"/>
    <dbReference type="HOGENOM" id="CLU_2695532_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04014">
        <property type="entry name" value="MazE_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="AbrB/MazE/MraZ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="1">
        <location>
            <begin position="33"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="73" mass="8209" checksum="29DEF59BD21CE091" modified="2014-10-29" version="1">MHLDHHDSNIYIGNRGYIRQSDMITSKVQTANQVSGSIRVTIPYEIAKALKLEVGDVLAWDLDGKKATVRKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRX4</accession>
    <name>A0A075MRX4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphoribosyl-AMP cyclohydrolase</fullName>
            <ecNumber evidence="3">3.5.4.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NTE_00075</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>1-(5-phospho-beta-D-ribosyl)-5'-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:20049"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="EC" id="3.5.4.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.19" evidence="3"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699213.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRX4"/>
    <dbReference type="STRING" id="1459636.NTE_00075"/>
    <dbReference type="GeneID" id="41596023"/>
    <dbReference type="KEGG" id="nev:NTE_00075"/>
    <dbReference type="eggNOG" id="arCOG02676">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048577_5_3_2"/>
    <dbReference type="OrthoDB" id="5853at2157"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00008"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004635">
        <property type="term" value="F:phosphoribosyl-AMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004636">
        <property type="term" value="F:phosphoribosyl-ATP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.810:FF:000001">
        <property type="entry name" value="Histidine biosynthesis bifunctional protein HisIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.810">
        <property type="entry name" value="Phosphoribosyl-AMP cyclohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002496">
        <property type="entry name" value="PRib_AMP_CycHydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038019">
        <property type="entry name" value="PRib_AMP_CycHydrolase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000768">
        <property type="entry name" value="PRK00051.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42945">
        <property type="entry name" value="HISTIDINE BIOSYNTHESIS BIFUNCTIONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42945:SF1">
        <property type="entry name" value="HISTIDINE BIOSYNTHESIS BIFUNCTIONAL PROTEIN HIS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01502">
        <property type="entry name" value="PRA-CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141734">
        <property type="entry name" value="HisI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoribosyl-AMP cyclohydrolase" evidence="7">
        <location>
            <begin position="33"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF82159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="111" mass="12535" checksum="1A6F84DA30ABCCDA" modified="2014-10-29" version="1">MNVKSANDVDFAKRGGVLPVIVQDRKTKDVLTLVYANREALENTIKTGNAWFWSTSRNKLWMKGEESGNVQPVHEILVDCDSDALLYIVDSDKPMCHTGDRTCFHNVLKQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRY0</accession>
    <name>A0A075MRY0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Replication-associated protein ORF2/G2P domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01794</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700551.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRY0"/>
    <dbReference type="STRING" id="1459636.NTE_01794"/>
    <dbReference type="GeneID" id="41597560"/>
    <dbReference type="KEGG" id="nev:NTE_01794"/>
    <dbReference type="HOGENOM" id="CLU_738897_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056906">
        <property type="entry name" value="ORF2/G2P_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23343">
        <property type="entry name" value="REP_ORF2-G2P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Replication-associated protein ORF2/G2P" evidence="1">
        <location>
            <begin position="70"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="374" mass="43626" checksum="0C05EBB245A7F585" modified="2014-10-29" version="1">MLKREDLSDAKIDYLAIKSAKRGNDVYEYRIKQRLKPIEIMADELDGDIFEDDDMTILNDKTSKAWTNALFVTLTYDINRSNSPTAWRDLGSDLNLFLANIRKQFGKISYIRAFEAFGNGYPHIHLLIIFKETRFKVFKYHDVYRLEDKHIFESWYHSFVDIRAVRNLKHAIRYIVKYLKKLNGNLKEAKPENYYKALLTQGLQWLYNKRAYAVSGDFLRVLKAERARLESMKHNSNLLKLSDGTRGKVIGYDLLGQPILKKFKFTFLGSFAWKNIIICGNYTKEEGTPWLMVGIDPHKLPEQDKARIRSFDPSFESEPESTADGMIRLYEHSDIWLCVKCKRRGDKWDVIGHTCKASVRESAAINPHGLDVYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MS08</accession>
    <name>A0A075MS08_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00107</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_193354081.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MS08"/>
    <dbReference type="STRING" id="1459636.NTE_00107"/>
    <dbReference type="GeneID" id="59387783"/>
    <dbReference type="KEGG" id="nev:NTE_00107"/>
    <dbReference type="eggNOG" id="arCOG08792">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3056955_0_0_2"/>
    <dbReference type="OrthoDB" id="3973at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75712">
        <property type="entry name" value="Rad50 coiled-coil Zn hook"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="54" mass="5738" checksum="750918BA56E77075" modified="2014-10-29" version="1">MMSADVVCGKCGSVIYTMRMLKSVKDALRATNNRCPVCGAALNPADFTVAATKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MS11</accession>
    <name>A0A075MS11_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative Fe-S oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NTE_02247</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MS11"/>
    <dbReference type="STRING" id="1459636.NTE_02247"/>
    <dbReference type="KEGG" id="nev:NTE_02247"/>
    <dbReference type="eggNOG" id="arCOG00938">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_881677_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050377">
        <property type="entry name" value="Radical_SAM_PqqE_MftC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11228:SF7">
        <property type="entry name" value="PQQA PEPTIDE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11228">
        <property type="entry name" value="RADICAL SAM DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01067">
        <property type="entry name" value="SPASM/twitch_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="71"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF84301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="347" mass="40112" checksum="7424C80519C9B1DA" modified="2014-10-29" version="1">MFVFSYESYHVYRDSLLSERDLYYTVVNLIYGRGITELLREMPFYISIFKKIIAYRLFKSKQPMYGSVDVNNICNLHCTHCYWWLNRKKGEQDLTAEDWRRIIRDKFNKQKIFVTTLVGGEPTLRPDVIEIFCKEMPRRVCVVTNATFPLRRFNGLYFYWVSMDGTEKVHDSIRGEGSYAMTKKNILDYVAGPDRDGRPAWTDIWISMTINSLNYMTVEELIEEWRGKVNKIGFQFHTPFVKGDPLMLPFGVVRNQVVDKLIEMKRKYPDFVVNPVKQLSLMKGNWGGTGTTPVDCPSWAILSLDHMGRVKQPCCIGSADAKSMKPLCEECGLGCYSILVSQGIRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MS77</accession>
    <name>A0A075MS77_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01911</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700637.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MS77"/>
    <dbReference type="GeneID" id="41597660"/>
    <dbReference type="KEGG" id="nev:NTE_01911"/>
    <dbReference type="HOGENOM" id="CLU_2204193_0_0_2"/>
    <dbReference type="OrthoDB" id="6694at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="108" mass="11891" checksum="7B92FEFAF748C092" modified="2014-10-29" version="1">MAINDFALACAIDNSPGYFTYDDQTMLIIQSAQDAKAGQSSFSYIEPFMDALVSHEAIHVAIKKLEGDDASESLDDIEVIVEHNGRRFQVTLNNILFASDNSGLVMPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSF8</accession>
    <name>A0A075MSF8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cell division GTPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_02467</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSF8"/>
    <dbReference type="STRING" id="1459636.NTE_02467"/>
    <dbReference type="KEGG" id="nev:NTE_02467"/>
    <dbReference type="eggNOG" id="arCOG02201">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_859474_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045061">
        <property type="entry name" value="FtsZ/CetZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30314">
        <property type="entry name" value="CELL DIVISION PROTEIN FTSZ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30314:SF3">
        <property type="entry name" value="MITOCHONDRIAL DIVISION PROTEIN FSZA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="3">
        <location>
            <begin position="5"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF84516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="318" mass="33969" checksum="3C3B1A837B2F70F8" modified="2014-10-29" version="1">MIKNPLLVVGIGGAGSRLAKKVSEAIDCECLLMSNDKRDLADSNNSILVNSGKWVNPSAYKLRSFASAKQEQIRAKLEGFGTVLVIANLAGRAGAAMAPLVCGIAGKTSTVISFAIMPFGFEKDRVFSAGVSLRRMREASHSTVVMDNDAFLDNNPDLSKEECYSLTNSAIVEVASSIASRSVRPDMNILSTSKASADSQASLRDSVSMLYQDITDADAIRRTVVYVMGGEKLPISQLNQLIGYAQGIFKEEGATEVAMSSLAVADGGVRVHVVASAPQKTRFDAYDPLGEIFSADSHLDWDEPDSAPDLELAIPLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSG0</accession>
    <name>A0A075MSG0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription elongation factor NusA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01666</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700446.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSG0"/>
    <dbReference type="STRING" id="1459636.NTE_01666"/>
    <dbReference type="GeneID" id="41597441"/>
    <dbReference type="KEGG" id="nev:NTE_01666"/>
    <dbReference type="eggNOG" id="arCOG01761">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132460_1_0_2"/>
    <dbReference type="OrthoDB" id="4111at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="168" mass="18761" checksum="49A93145FC819EF9" modified="2014-10-29" version="1">MKTPICSFDAKSGVLCAKCDEKLHAGNITQDDVDAAVRLTRVANKSQDVDRFTLSRGARVDDDYILVLRGPDVMSIRANPSLAERIEREFGHKVHYVESEASERGLVESLFHPARVLSINHFYLPDGNKVTKAVVAGKSSSQKINVEKVQRIAKAVRNIELLVEFEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSI5</accession>
    <name>A0A075MSI5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02492</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSI5"/>
    <dbReference type="STRING" id="1459636.NTE_02492"/>
    <dbReference type="KEGG" id="nev:NTE_02492"/>
    <dbReference type="eggNOG" id="arCOG01055">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_160435_0_0_2"/>
    <dbReference type="OrthoDB" id="1242at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038723">
        <property type="entry name" value="ArnR1-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14947">
        <property type="entry name" value="HTH_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ArnR1-like winged helix-turn-helix" evidence="1">
        <location>
            <begin position="6"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="101" mass="12037" checksum="E21C5A1A6CCA5B11" modified="2014-10-29" version="1">MVHAHRERIYIRKDIILKLSDYGELNQSQLMSYCGLNNVKHKPIVDELVEKGLIIRFEEPWGEQNRIIKYRVSEKGREIVKAVLEPYELLFPRGEDKEKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSP8</accession>
    <name>A0A075MSP8_9ARCH</name>
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        <submittedName>
            <fullName evidence="7">NADH:ubiquinone oxidoreductase chain I-like protein</fullName>
            <ecNumber evidence="7">1.6.5.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NTE_02554</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.6.5.3" evidence="7"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701142.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSP8"/>
    <dbReference type="STRING" id="1459636.NTE_02554"/>
    <dbReference type="GeneID" id="41598249"/>
    <dbReference type="KEGG" id="nev:NTE_02554"/>
    <dbReference type="eggNOG" id="arCOG01543">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067218_4_5_2"/>
    <dbReference type="OrthoDB" id="23833at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010226">
        <property type="entry name" value="NADH_quinone_OxRdtase_chainI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849:SF35">
        <property type="entry name" value="FORMATE HYDROGENLYASE SUBUNIT 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE IRON-SULFUR PROTEIN 8, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="55"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="97"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF84601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="166" mass="18659" checksum="A8B3D2463D88A841" modified="2014-10-29" version="1">MSGTASGFIKAIESGSKHLVIRRFTFRYPEQKLRFVGDGYQFDPKRGVGIAGYRGRHILMHDKCTGCQLCAIACEGIAEAIGMVKVDENWKQNKKSIMPQIDYGKCVFCGLCVDACPFYALFMTNDYELSGFTKEHLIYTPQQLEVKPKYEGDVEIRITDRGASHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSR6</accession>
    <name>A0A075MSR6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00312</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSR6"/>
    <dbReference type="KEGG" id="nev:NTE_00312"/>
    <dbReference type="HOGENOM" id="CLU_3075137_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="52" mass="5966" checksum="D1970EBC51CAB3D8" modified="2014-10-29" version="1">MAIVSEPVRPLIGNILRYIQRERKTRALFSFSLFHLLSLCQEFVGESVVGFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MT23</accession>
    <name>A0A075MT23_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_02307</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700944.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MT23"/>
    <dbReference type="STRING" id="1459636.NTE_02307"/>
    <dbReference type="GeneID" id="41598022"/>
    <dbReference type="KEGG" id="nev:NTE_02307"/>
    <dbReference type="eggNOG" id="arCOG01622">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_10_0_2"/>
    <dbReference type="OrthoDB" id="25239at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051450">
        <property type="entry name" value="Gfo/Idh/MocA_Oxidoreductases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43377">
        <property type="entry name" value="BILIVERDIN REDUCTASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43377:SF1">
        <property type="entry name" value="BILIVERDIN REDUCTASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="1">
        <location>
            <begin position="10"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="2">
        <location>
            <begin position="135"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF84360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="319" mass="34942" checksum="541F5122FD9C8F6F" modified="2014-10-29" version="1">MVENNSSNSKIAVIGVGGWGKNHARVLGELGVLGAVCDFDAARAKEIASKHNAAPYSSVDEMLEKERLDACLVCTPTRTHSAVAKKVIDQGLHAFVEKPLSFSSQECDEMTELARKKRVTLTCGYIERFNPAVSETKKMIADKKCGDLLMLEFHRENRMPPKIKDVGIIFDTAVHDIDTAMFLFDARPNVVFARAGRHVHEFEDFATLMLGFANQRVAIISVNWLTPKKVRTFSAVCTDGIISGNFISQEIKIDNAGETVAPRLPFQEPLTLELKSFIAAVQGKENSAVSARDATNVTKVAEAALLSSETGSPIYLDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MT60</accession>
    <name>A0A075MT60_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chemotaxis protein CheA</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">NTE_02348</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700981.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MT60"/>
    <dbReference type="STRING" id="1459636.NTE_02348"/>
    <dbReference type="GeneID" id="41598064"/>
    <dbReference type="KEGG" id="nev:NTE_02348"/>
    <dbReference type="eggNOG" id="arCOG04403">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000650_3_7_2"/>
    <dbReference type="OrthoDB" id="293137at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16916">
        <property type="entry name" value="HATPase_CheA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00088">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000016">
        <property type="entry name" value="Chemotaxis protein CheA, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.560">
        <property type="entry name" value="Histidine kinase CheA-like, homodimeric domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="entry name" value="HPT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051315">
        <property type="entry name" value="Bact_Chemotaxis_CheA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004105">
        <property type="entry name" value="CheA-like_dim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037006">
        <property type="entry name" value="CheA-like_homodim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036061">
        <property type="entry name" value="CheW-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002545">
        <property type="entry name" value="CheW-lke_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43395:SF10">
        <property type="entry name" value="CHEMOTAXIS PROTEIN CHEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43395">
        <property type="entry name" value="SENSOR HISTIDINE KINASE CHEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01584">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02895">
        <property type="entry name" value="H-kinase_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00260">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01231">
        <property type="entry name" value="H-kinase_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00073">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50341">
        <property type="entry name" value="CheW-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="Histidine-containing phosphotransfer domain, HPT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50851">
        <property type="entry name" value="CHEW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="8 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 11" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="HPt" evidence="15">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="13">
        <location>
            <begin position="195"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="CheW-like" evidence="14">
        <location>
            <begin position="399"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="130"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="11">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AIF84400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="537" mass="59580" checksum="2B7A8ECDC9CE824D" modified="2014-10-29" version="1">MSDDKSAYRDLFVQEAHEHVQNMNQALLKLEEDPKNKEHLDSAFRSAHTLKGMAATMGYDQIKELCKAIEELFDKFRKGEEKMSSEMASYLFKCFDAVQEMVDDENKKVNIEQYLSDLRNPAAMGGGNAAGQEGASQQQQQQQHSALPQTIRVKMQDLDALVDLVGELLIAKMRLEQMVGNTTTDNRVRHTFMSLGRLVSDLQYQTMKLRLVPVEQIFNRFPRMIRDLSSSQGKSVKLEIEGLGIELDRTVLDAITDPLLHMLRNAADHAIEMPEEREAAGKPQTGTIKLIASKVGDRVMITVEDDGRGIDLEKVKAKAIEKKIVTKEEADSMSEQDVLDLLGTPGLSTAKQVTDISGRGVGMDVVFSQIESVGGQVKIETKKGQGTRFTMIIPLSLAIIGGLLVTISNEKYVLPLSSVISTMRVDKKDVRIVHGKEVILFREQVVPLLRTGKTLGISQQQQQQADNNNDDDDNRYLTVVIVNKNGRPYGLIVDEFESKQEIVVKRLDSSSAPSSVSSEATILGDGKVALILDPARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MT92</accession>
    <name>A0A075MT92_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitrogen regulatory protein P-II family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02729</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the P(II) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701287.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MT92"/>
    <dbReference type="STRING" id="1459636.NTE_02729"/>
    <dbReference type="GeneID" id="41598419"/>
    <dbReference type="KEGG" id="nev:NTE_02729"/>
    <dbReference type="eggNOG" id="arCOG02305">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082268_3_0_2"/>
    <dbReference type="OrthoDB" id="10960at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006808">
        <property type="term" value="P:regulation of nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002187">
        <property type="entry name" value="N-reg_PII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017918">
        <property type="entry name" value="N-reg_PII_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30115">
        <property type="entry name" value="NITROGEN REGULATORY PROTEIN P-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30115:SF11">
        <property type="entry name" value="NITROGEN REGULATORY PROTEIN P-II HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00543">
        <property type="entry name" value="P-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00340">
        <property type="entry name" value="PIIGLNB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00938">
        <property type="entry name" value="P-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="GlnB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00638">
        <property type="entry name" value="PII_GLNB_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51343">
        <property type="entry name" value="PII_GLNB_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="115" mass="11662" checksum="7D855007779A1AA9" modified="2014-10-29" version="1">MKRIEAIIASEKVNAVNEALKKAGVGGATILDAKGRGKGEKPRVAGGRGTSAHLAEFSVRANVITVVDDGDVDRVIKAILDAASTGSAGDGKIFVSSVGEAVDIGSKKRSQSGMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MT94</accession>
    <name>A0A075MT94_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative RNA-binding protein, contains THUMP domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_02378</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701007.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MT94"/>
    <dbReference type="STRING" id="1459636.NTE_02378"/>
    <dbReference type="GeneID" id="41598093"/>
    <dbReference type="KEGG" id="nev:NTE_02378"/>
    <dbReference type="eggNOG" id="arCOG00084">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097042_0_0_2"/>
    <dbReference type="OrthoDB" id="26307at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11717">
        <property type="entry name" value="THUMP_THUMPD1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2300.10">
        <property type="entry name" value="THUMP superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004114">
        <property type="entry name" value="THUMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040183">
        <property type="entry name" value="THUMPD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13452">
        <property type="entry name" value="THUMP DOMAIN CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13452:SF10">
        <property type="entry name" value="THUMP DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02926">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00981">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143437">
        <property type="entry name" value="THUMP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51165">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="THUMP" evidence="2">
        <location>
            <begin position="62"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF84430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="176" mass="19590" checksum="3D2522F9EC0AD929" modified="2014-10-29" version="1">MNDFNLLVSSPRFREEDASDEILDLLDAFGDPDAEVQITRVAGIILARTSIHPVTVVEKLKELVASDPWEIRYVMRVLPIEKVVPAELEDISGAVGSMAARIPEGASFKIMVEKRHSDLHSREIIDYVAQEVKRKVDLENPSWVVLVEIVGRHAGVSVITPDKFFSSVVAKRESGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTG5</accession>
    <name>A0A075MTG5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00508</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699535.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTG5"/>
    <dbReference type="GeneID" id="41596380"/>
    <dbReference type="KEGG" id="nev:NTE_00508"/>
    <dbReference type="eggNOG" id="arCOG04362">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062767_3_0_2"/>
    <dbReference type="OrthoDB" id="11410at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="257" mass="29458" checksum="7D3EF467297679E3" modified="2014-10-29" version="1">MEELAEFLFILANRDRLTLLSEIRNERLRLSQLTAKISATPQETSKHLMRLRDAKLIEKDSDSFFGLTLFGETILKLVPSIHFMTQNREYFLSHDITSLPAEFIERIGELQQSRYVDKVGAVLAHTQRVVKDAEEYIWLMADHLLGNQNYVINSGKLESSSVTWKIIVPHGSRDDWANLRKSVGANKGRIEYRLMEDPKDIKLGTALNERLAGVVFPDSTGRLDFNGGFNGTDPVFCKWCRDLFLFHWNKAGRSVQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTK6</accession>
    <name>A0A075MTK6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02918</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTK6"/>
    <dbReference type="KEGG" id="nev:NTE_02918"/>
    <dbReference type="eggNOG" id="arCOG08706">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2327137_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="98" mass="11206" checksum="EA2375C5066AB57B" modified="2014-10-29" version="1">MCSVSILLELRHQNAIRLPDITDMIASEADDENFMKIVDDLVVSAEGDPELAEGLKWIDMQSRRNGVTFYEMALIILKKHMAERRAREWMKARSVAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTK9</accession>
    <name>A0A075MTK9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Parallel beta-helix repeat (Two copies)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02401</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701025.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTK9"/>
    <dbReference type="STRING" id="1459636.NTE_02401"/>
    <dbReference type="GeneID" id="41598112"/>
    <dbReference type="KEGG" id="nev:NTE_02401"/>
    <dbReference type="HOGENOM" id="CLU_474599_0_0_2"/>
    <dbReference type="OrthoDB" id="9689at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022441">
        <property type="entry name" value="Para_beta_helix_rpt-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03804">
        <property type="entry name" value="para_beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Right handed beta helix" evidence="1">
        <location>
            <begin position="392"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="574" mass="64010" checksum="A290FC1239B7F18D" modified="2014-10-29" version="1">MKYTSVLLCALLASTFGIVIWNMYLPVSSNRNAEFIDYLGYSAKKAYNNNDFLKNNITPIATQLGLGPAPPLPNVGPRILYDPSMPSTVTLTFYVQYGNQENLLPLLDLLQNYNVSKAVFFIEDRFLKEHDFVAKRIQDQGYVIKTWDDLSGYKAAGYLPSVYRGVPLVENEILGQTGRDRDAMEFIRVALRHADSSVIAFSPKIMAHKIVLEDVLKQDGKGIVFSDQPAAAASPQQPSDSQVPPLVLISDGNNSATRVNEGKWTMDLLSKQYPSAVRYNEQESAYLVTRPIIMGNNTTLEINGVRVLLLSSSERNPNPTYLEIRGNAAIANSTVTSWDPVRARPEIDPYIPRPYIVVRGGHMDVLNSTITHLGYSLGGLKDTRYAHAALEYYNAKDFVVANSTIAFNYYGFYSEDSSDFRILNNEIYGQTRYGLDPHTRSVNFVVDSNNVHDNGNQGIICSLWCNNVTITNNIVEYNVEGIGLHWLTNSSIVKDNVVRFNEKYGVFIQKESYNNSVENNIIVGNKYGVGILEGSSRNTVANNVVADNVLERFRIDADSTGNTMRDNRYSVSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTM9</accession>
    <name>A0A075MTM9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02438</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTM9"/>
    <dbReference type="STRING" id="1459636.NTE_02438"/>
    <dbReference type="KEGG" id="nev:NTE_02438"/>
    <dbReference type="HOGENOM" id="CLU_3245175_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="42" mass="4645" checksum="4E563DF1C6023080" modified="2014-10-29" version="1">MASIVPEQVVNNMYPTPRPVAYYGCVMHGRGSLTIKTATLDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTU4</accession>
    <name>A0A075MTU4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Arginine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Arginyl-tRNA synthetase</fullName>
            <shortName evidence="8">ArgRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">argS</name>
        <name evidence="12" type="ORF">NTE_03016</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>tRNA(Arg) + L-arginine + ATP = L-arginyl-tRNA(Arg) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="8"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701520.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTU4"/>
    <dbReference type="STRING" id="1459636.NTE_03016"/>
    <dbReference type="GeneID" id="41598686"/>
    <dbReference type="KEGG" id="nev:NTE_03016"/>
    <dbReference type="eggNOG" id="arCOG00487">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006406_6_1_2"/>
    <dbReference type="OrthoDB" id="372102at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000006">
        <property type="entry name" value="Arginyl-tRNA synthetase 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="entry name" value="Arginyl tRNA synthetase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00123">
        <property type="entry name" value="Arg_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005148">
        <property type="entry name" value="Arg-tRNA-synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002447">
        <property type="entry name" value="PRK01611.3-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956:SF5">
        <property type="entry name" value="ARGININE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="ARGINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03485">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM01016">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55190">
        <property type="entry name" value="Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arginyl tRNA synthetase N-terminal" evidence="11">
        <location>
            <begin position="8"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="DALR anticodon binding" evidence="10">
        <location>
            <begin position="527"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="8">
        <location>
            <begin position="138"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIF85051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="647" mass="72629" checksum="340F3E71E1149979" modified="2014-10-29" version="1">MTFSRFKLQTHHAVFESMAKAGYNPVPFDVSEPPRKEFGDLTCNVAFLLSKQLRMAPPKIAQELIEKGIKPYLAEKKQQGQFSFIESVEPHPAGYVNFRFNYAVVAKDTLGYALESPDRYGYVDYGALERVVIEHTSVNPNKALHVGHMRNVILGDTLYRIMKAANNKVTVLNYVDDSGLQVADIVIGFLYAGFPREPPDGRKFDQYSGDEVYVKVNQMYEKDPTLAEKRKLVLREIEEGKSEIARFAAEITKRVLDEQLKTCWRMKVHYDILNFESQIVHSQMWSKAFELLKKEGLVRFEEEGKNKGCWVIEAEGEEDKVVVRSDGTATYIAKDIPYAAWKLGLVPDPFNYEKYAEQWDGATLYATTLDKGTASSFEGGDRVITIIDSRQARLQRIISQVLGKIGTDAERKHHHDYQHLGYEAVTLSANTARALGIDIGDRQFMHMSGRKGIYVGADFVLDHLRGKAIGEVKTRNPEFSDEQAGQIAEEIAVSAIRYNMIKQDLDKIITFDINESMSLEGDTGPYLQYAFARSQRILEKSGTAATETTTAAIDYALLKGEAEIELIKEISKMDLVVEDAAKSLSPKTLARYAYNLATTFNIFYEKVPVLRAQDAGTLAARLALVRALGIALKNALSMLGITALNKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTU6</accession>
    <name>A0A075MTU6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02132</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700809.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTU6"/>
    <dbReference type="GeneID" id="41597860"/>
    <dbReference type="KEGG" id="nev:NTE_02132"/>
    <dbReference type="HOGENOM" id="CLU_181205_0_0_2"/>
    <dbReference type="OrthoDB" id="375818at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="91" mass="10302" checksum="51AC35118B5C585E" modified="2014-10-29" version="1">MLVNGLIDKLLKARVAEKRDGELTFTNSFGGYLLCSISCSFIKIDTIQGWREILANFESSLANLTTEEIEATVMLLDYYLNHAQRAIVDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MU05</accession>
    <name>A0A075MU05_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MEDS: MEthanogen/methylotroph, DcmR Sensory domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701173.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MU05"/>
    <dbReference type="GeneID" id="41598288"/>
    <dbReference type="KEGG" id="nev:NTE_02595"/>
    <dbReference type="eggNOG" id="arCOG02358">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_965062_0_0_2"/>
    <dbReference type="OrthoDB" id="378113at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025847">
        <property type="entry name" value="MEDS_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14417">
        <property type="entry name" value="MEDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MEDS" evidence="1">
        <location>
            <begin position="114"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="288" mass="32206" checksum="2236DF48B53B9882" modified="2014-10-29" version="1">MLTRKAADAIEDSLTDFLGAEVWRVLRNKLDCSCGVRLDNILERSTAVKFAQALNEMLPPAAPFILDKVSARLMHDFPRIRDADQLSNFLHVVNEVRRRYDGANVLSGLENHQHVALVYRSENDFSKILSSFCAAGAKKNRLNVLVCPEELQEHAKALMANASLAEASSSLSQQQQQQQQSQQNLVMLDCTKLDVGKTQMRTSMESTLRSVCKAAAREKKSGLNVLGLCPSHLLAHENYLNCMALEDAWEDLVSTVGLPVSLVCPYMWDPCIPESRLEQNHNHGVRYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MU53</accession>
    <name>A0A075MU53_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cyclophilin TM1367-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MU53"/>
    <dbReference type="STRING" id="1459636.NTE_02635"/>
    <dbReference type="KEGG" id="nev:NTE_02635"/>
    <dbReference type="eggNOG" id="arCOG04488">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_144084_1_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025658">
        <property type="entry name" value="Cyclophilin_TM1367"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04126">
        <property type="entry name" value="Cyclophil_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclophilin TM1367-like" evidence="1">
        <location>
            <begin position="24"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="148" mass="16636" checksum="68ED1E544E090BCB" modified="2014-10-29" version="1">MVQRNNTMTNKKKKALLLEFSKIGEKVEIELDDTQSPRTVGAIVDSLPLTMTIERWGDELYSEATPVKVAEENARSEVCLFDVAYWPQGSALCFFYGPTPITSKAGKILPYSPVNIVGRIKSRPADIQDFLRRVEEAHVAERVPVVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MU59</accession>
    <name>A0A075MU59_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02198</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MU59"/>
    <dbReference type="STRING" id="1459636.NTE_02198"/>
    <dbReference type="KEGG" id="nev:NTE_02198"/>
    <dbReference type="HOGENOM" id="CLU_155849_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="125" mass="13791" checksum="0279334FC53A9339" modified="2014-10-29" version="1">MTRKKVLLIGIDPKLVDFSKSTTGWDAKKVQAAGQDADKRLKELGYEVQGCLVDLGETAESVVSNTLSRQTFDCILIGAGIRALPQHTHMFEKIINIIHQKAPPSAKICFNTNPSDTVEAVLRWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MU76</accession>
    <name>A0A075MU76_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane-associated phospholipid phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_02655</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385527.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MU76"/>
    <dbReference type="STRING" id="1459636.NTE_02655"/>
    <dbReference type="GeneID" id="41598347"/>
    <dbReference type="KEGG" id="nev:NTE_02655"/>
    <dbReference type="eggNOG" id="arCOG03056">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072573_10_3_2"/>
    <dbReference type="OrthoDB" id="10182at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042392">
        <property type="term" value="F:sphingosine-1-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03392">
        <property type="entry name" value="PAP2_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969:SF13">
        <property type="entry name" value="AT30094P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="2">
        <location>
            <begin position="88"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF84698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="241" mass="26113" checksum="19E5EA3946612A13" modified="2014-10-29" version="1">MSAAANPPWMFRTRSFQFVAFLAAFVVFSAVVASGATNVIDEPVNKYAKSIEGNPGLDAVMIAITTMGDVATLLLFAIAITIVRRTRKAGMIFLISIVALAIAVMYLKPFVGRTAPPYEFVPAVKLPENFGIESDSLAPFAAAFSYPSGHVSRATALAFIVGYLLYRKSRVAGYAIWAFPIVIGITRVYVQQHFPTDLIGGFLIGMIISVVLSNSMKLWQPFQLSRFKGKEDEEGAKASSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUE3</accession>
    <name>A0A075MUE3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetyl/propionyl-CoA carboxylase, alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_02774</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701324.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUE3"/>
    <dbReference type="STRING" id="1459636.NTE_02774"/>
    <dbReference type="GeneID" id="41598463"/>
    <dbReference type="KEGG" id="nev:NTE_02774"/>
    <dbReference type="eggNOG" id="arCOG02699">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016733_5_1_2"/>
    <dbReference type="OrthoDB" id="6555at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050709">
        <property type="entry name" value="Biotin_Carboxyl_Carrier/Decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45266">
        <property type="entry name" value="OXALOACETATE DECARBOXYLASE ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45266:SF3">
        <property type="entry name" value="OXALOACETATE DECARBOXYLASE ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0092">Biotin</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="2">
        <location>
            <begin position="99"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF84815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="170" mass="18205" checksum="9A1E6ECE1915BF9F" modified="2014-10-29" version="1">MEFKVGDLAQMLSGEVLRTTGNNSVLVKIGDKEHTIRLLKSGTNEFEFILDNTFHHAKILQSGSAEVKLMLDGQPITVKKHSKLTEVLEKASALGGAGGGDRNLASQIPGRVVNIAAKPGTEVKKGDVIVVLESMKMQVAVKAHKDGNLKEIKVKQGASVARNDILAVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUI1</accession>
    <name>A0A075MUI1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta hydrolase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_02830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701371.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUI1"/>
    <dbReference type="STRING" id="1459636.NTE_02830"/>
    <dbReference type="GeneID" id="41598514"/>
    <dbReference type="KEGG" id="nev:NTE_02830"/>
    <dbReference type="eggNOG" id="arCOG01661">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_632547_0_0_2"/>
    <dbReference type="OrthoDB" id="203477at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053145">
        <property type="entry name" value="AB_hydrolase_Est10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43265">
        <property type="entry name" value="ESTERASE ESTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43265:SF1">
        <property type="entry name" value="ESTERASE ESTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="2">
        <location>
            <begin position="114"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF84870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="433" mass="47370" checksum="ECE3E1215F6205EC" modified="2014-10-29" version="1">MIKSALAIVLSLFIIPVTVFAQGDSVPTTNSTDGSTSVPSGSSSSPSSTNVSDDEHSKTIRHRDLTIDLGGGIHTDAELTLPALANHSLPALLLIHGLGPADKDHFFPPDIRPFKQIAEYMSERGFVVLRYDKRAIGANSTVENLGLWYNETMDDLISDANKALHTLAKQPEFDKNNISIFGASQGTWIATRVAAANPFVKNVVLMSSAADKIGDLIHTQMVNTTLQFTREVLDVNHDGLLSLSEVAATRNTPYWTLGPLPGKILVDNNSGSATGNFQFIEGLRTGEVNVGNEEKAVKIDTTLRAFLEQRFQSIFVDTKDKSCPYLGVGCPPMMRSFADMDNLSVIGNLNSTGILLIHGGRDIGQPPEQAFMLEQKLLALNHPDHTIIVYPGHGHGLINIGKDSWIDRPGRLPDYLLEDMYSWLTDPDRNWNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUR9</accession>
    <name>A0A075MUR9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NTE_02860</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701394.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUR9"/>
    <dbReference type="GeneID" id="41598542"/>
    <dbReference type="KEGG" id="nev:NTE_02860"/>
    <dbReference type="eggNOG" id="arCOG04641">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064906_2_1_2"/>
    <dbReference type="OrthoDB" id="116318at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005115">
        <property type="entry name" value="Gly_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30506">
        <property type="entry name" value="INNER MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30506:SF3">
        <property type="entry name" value="UPF0126 INNER MEMBRANE PROTEIN YADS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03458">
        <property type="entry name" value="Gly_transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine transporter" evidence="7">
        <location>
            <begin position="14"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine transporter" evidence="7">
        <location>
            <begin position="101"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF84898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="210" mass="22258" checksum="D04707AABB31694F" modified="2014-10-29" version="1">MADPGLSVSTLIQFLDLFGTAAFAATGAFKAVEHKSDIVGIIILATITGVAGGVLRDVIFGRIPPVAIANPFYVIITIGMAVAIFFLYRSFKHYEGLILKFDAVGLGVFTIIGASFAYSVFGMNFLAMAFAGIVTAIGGGILRDVFVNEVPIVFVKELYASASFAGVVVFFGMLAAGVDVNVAAIPCIALVTGLRMFAMKYNWNLPRPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUS8</accession>
    <name>A0A075MUS8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mg-dependent DNase</fullName>
            <ecNumber evidence="3">3.1.21.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_02375</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.21.-" evidence="3"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUS8"/>
    <dbReference type="STRING" id="1459636.NTE_02375"/>
    <dbReference type="KEGG" id="nev:NTE_02375"/>
    <dbReference type="eggNOG" id="arCOG00891">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031506_5_1_2"/>
    <dbReference type="OrthoDB" id="26412at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018228">
        <property type="entry name" value="DNase_TatD-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46124">
        <property type="entry name" value="D-AMINOACYL-TRNA DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46124:SF2">
        <property type="entry name" value="D-AMINOACYL-TRNA DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005902">
        <property type="entry name" value="DNase_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01090">
        <property type="entry name" value="TATD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR005902-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF84427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="280" mass="31193" checksum="B391B3E99E384E84" modified="2014-10-29" version="1">MKTQVRDGGRLLKVLIPFRRHAAVLLYDAHVHLTDSEYSGYLDHVFSSLYAMRIVACSVAVDLETTKKSLRLFKDRKDVIKQFVGIHPEFAAREDLDKFVQVARDNMASIDGIGEIGLDGTYEAERGVPYERQKQVFHAMLALAESEGKPVSIHSRRALDDILAILPSFRLRGALLHWFAGSKKQLARSMDMGLYVSYGPALVYSDDKKVLLKHTRRDRFLVETDGPVRYSRCFEGKPALPTSFLPSVVASAAAVLGVSYGEAAETTARNTEAFLGSQQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MV10</accession>
    <name>A0A075MV10_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02963</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701472.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MV10"/>
    <dbReference type="STRING" id="1459636.NTE_02963"/>
    <dbReference type="GeneID" id="41598634"/>
    <dbReference type="KEGG" id="nev:NTE_02963"/>
    <dbReference type="HOGENOM" id="CLU_1056086_0_0_2"/>
    <dbReference type="OrthoDB" id="11913at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="326" mass="32678" checksum="89556C0FA1AB277E" modified="2014-10-29" version="1">MNRHAQVISAAVAAVLVSALVVASFAATKSYAQNPLGNQTSGNQTGSAAGGNQTGLTTGNQTMITTQPPNATTGNQTAAGNQIGSAAGNQTGTIPKQGERLTGRIASIQVENGQPTWIQAGIWMLRINATGPAVPGGNVTAPGGNVTAPGGNVTAPGGNVTAPGGNLTAPGGNMTGGNQTGGNTTPTAFEGNLDQATPPAPPAPGGNLTAPGNVTAPGNVTAPTGGGMAIPNLYFIAKFDMVQLNGSAMHQHNVTDLKATKFTFENNTYTIEGTATVTMKNGPVQDVPVSIKIMDDSVIALTIGPDKVDSHFGTDPIYGTVAKERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVB8</accession>
    <name>A0A075MVB8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_03074</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701564.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVB8"/>
    <dbReference type="STRING" id="1459636.NTE_03074"/>
    <dbReference type="GeneID" id="41598737"/>
    <dbReference type="KEGG" id="nev:NTE_03074"/>
    <dbReference type="eggNOG" id="arCOG03748">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120314_0_0_2"/>
    <dbReference type="OrthoDB" id="11852at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="160"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF85108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="224" mass="23581" checksum="5FC578653B7CDE99" modified="2014-10-29" version="1">MSEAHNSIGATENNNSPKHFMVLDAISRGMDDIGKIAKVTKLDKAEVELAVNDLAAQRLVLASAKKRRLFGRRALQVSITETGTRLLEEKKRQLERKAIDLRNSYRNGDRQATQSFMDENRAWLPMMIFSGLMSAVMFASIMSFAGMAMNPAESAMAGDAAATAASSQETSADSGAGESSNESADGGGGADFGTISDTNSSDSGSSSDAGFDATGGDLGGDMEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVE9</accession>
    <name>A0A075MVE9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701651.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVE9"/>
    <dbReference type="STRING" id="1459636.NTE_03185"/>
    <dbReference type="GeneID" id="41598841"/>
    <dbReference type="KEGG" id="nev:NTE_03185"/>
    <dbReference type="eggNOG" id="arCOG13317">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1922679_0_0_2"/>
    <dbReference type="OrthoDB" id="384922at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="131" mass="14326" checksum="1C65EBA4DF992A37" modified="2014-10-29" version="1">MQDNHRAHAKSGGHEKTGHGMDDGKHGAHGRTMVKNYNINLQSDPATPEAGKPTKLALVVTEQSIGDPITEFDAVHDKLMHLFIVNRNDLSYFAHLHLQLDNSSGIFTVTHTFPESGEYKAWADAKPKGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVF2</accession>
    <name>A0A075MVF2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nitrogen regulatory protein PII</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01161</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVF2"/>
    <dbReference type="STRING" id="1459636.NTE_01161"/>
    <dbReference type="KEGG" id="nev:NTE_01161"/>
    <dbReference type="eggNOG" id="arCOG02305">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082268_3_1_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006808">
        <property type="term" value="P:regulation of nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002187">
        <property type="entry name" value="N-reg_PII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30115">
        <property type="entry name" value="NITROGEN REGULATORY PROTEIN P-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30115:SF11">
        <property type="entry name" value="NITROGEN REGULATORY PROTEIN P-II HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00543">
        <property type="entry name" value="P-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00340">
        <property type="entry name" value="PIIGLNB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00938">
        <property type="entry name" value="P-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="GlnB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51343">
        <property type="entry name" value="PII_GLNB_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="116" mass="12627" checksum="2C7C15DB423C6D3C" modified="2014-10-29" version="1">MPGMKKIELIVPNRWVGEIDNALKEVQIGGMSVTRIEGRGRVKPARVAISRGTGLATPEFIPRTKIEVVVRENLAEVIKKVLDKFGGDPNLGGKAFISDVSGAVDFVTQKRDEEAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVH7</accession>
    <name>A0A075MVH7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03141</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701617.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVH7"/>
    <dbReference type="GeneID" id="41598800"/>
    <dbReference type="KEGG" id="nev:NTE_03141"/>
    <dbReference type="eggNOG" id="arCOG10531">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1830646_0_0_2"/>
    <dbReference type="OrthoDB" id="384456at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="154" mass="17493" checksum="8AA37ABC7E86A5CC" modified="2014-10-29" version="1">MTADSGSSSLIITCISDDSIQFAKEVYDYLYSKLEQQKAQFTEESKGLNVAQDLITLHVREKGEGEQAGGEESQIRVDRLANIPKGMIKWILESFLKSNPSRFKDYEVIELGETFTIGRVLSPSKMEMLTCEICGFFTPYSEELYTHRMTHFGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVI0</accession>
    <name>A0A075MVI0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">acylphosphatase</fullName>
            <ecNumber evidence="1">3.6.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_03206</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an acyl phosphate + H2O = a carboxylate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="EC" id="3.6.1.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acylphosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.7" evidence="1"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVI0"/>
    <dbReference type="STRING" id="1459636.NTE_03206"/>
    <dbReference type="KEGG" id="nev:NTE_03206"/>
    <dbReference type="eggNOG" id="arCOG01674">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141932_3_2_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003998">
        <property type="term" value="F:acylphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020456">
        <property type="entry name" value="Acylphosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001792">
        <property type="entry name" value="Acylphosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036046">
        <property type="entry name" value="Acylphosphatase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017968">
        <property type="entry name" value="Acylphosphatase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47268">
        <property type="entry name" value="ACYLPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47268:SF4">
        <property type="entry name" value="ACYLPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00708">
        <property type="entry name" value="Acylphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54975">
        <property type="entry name" value="Acylphosphatase/BLUF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00151">
        <property type="entry name" value="ACYLPHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51160">
        <property type="entry name" value="ACYLPHOSPHATASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acylphosphatase-like" evidence="3">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="11"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF85235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="83" mass="9161" checksum="CCC171231AD44E6A" modified="2014-10-29" version="1">MTGKVQGVYFRQNTQLTAKEHGVTGWVRNLPDGRVEAVIEGDDAAVRKVVDWCRHGPSSARVDNIEVKHEGYTGEFASFEVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVJ4</accession>
    <name>A0A075MVJ4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ADP-dependent (S)-NAD(P)H-hydrate dehydratase</fullName>
            <ecNumber evidence="6">4.2.1.136</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ADP-dependent NAD(P)HX dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nnrD</name>
        <name evidence="8" type="ORF">NTE_02639</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(6S)-NADHX + ADP = AMP + phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32223"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.136"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(6S)-NADPHX + ADP = AMP + phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32235"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.136"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NnrD/CARKD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.136" evidence="6"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVJ4"/>
    <dbReference type="STRING" id="1459636.NTE_02639"/>
    <dbReference type="KEGG" id="nev:NTE_02639"/>
    <dbReference type="eggNOG" id="arCOG00018">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024853_2_2_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052855">
        <property type="term" value="F:ADP-dependent NAD(P)H-hydrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110051">
        <property type="term" value="P:metabolite repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046496">
        <property type="term" value="P:nicotinamide nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01171">
        <property type="entry name" value="YXKO-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01965">
        <property type="entry name" value="NADHX_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000631">
        <property type="entry name" value="CARKD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00196">
        <property type="entry name" value="yjeF_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12592:SF0">
        <property type="entry name" value="ATP-DEPENDENT (S)-NAD(P)H-HYDRATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12592">
        <property type="entry name" value="ATP-DEPENDENT (S)-NAD(P)H-HYDRATE DEHYDRATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01256">
        <property type="entry name" value="Carb_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51383">
        <property type="entry name" value="YJEF_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 6" id="KW-0520">NAD</keyword>
    <keyword evidence="3 6" id="KW-0521">NADP</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="YjeF C-terminal" evidence="7">
        <location>
            <begin position="15"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF84682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="295" mass="30856" checksum="5314DAA3CEC28137" modified="2014-10-29" version="1">MACSLPLVAVITTINLPLAKKLMPPRRASSKKGDNGTVLVAGGSRFYHGAPVFTSMAALRAGTDLVYTAVPRSIITEVRCFSPALIALPLPDDKLTVGAANRLAAMLPKKPDAAAIGMGMSIAGPEAIIALARKLKERGTKILLDASALVPEILPEIANANAVVTPHAGEYKRLFGEEAGETEKERIANVSANAKKHGITILLKGPTDIVSDGKSTGINRTHNCAMTVGGTGDVLAGITAGLMCKVPPFEAALLAVYFNGLAGNLAFNRVGLHMTSTDLLEDLPVAMKRFDVIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVM2</accession>
    <name>A0A075MVM2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative Ig domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NTE_02664</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701231.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="STRING" id="1459636.NTE_02664"/>
    <dbReference type="GeneID" id="41598356"/>
    <dbReference type="KEGG" id="nev:NTE_02664"/>
    <dbReference type="eggNOG" id="arCOG06534">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG07781">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG09729">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG11020">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_234913_0_0_2"/>
    <dbReference type="OrthoDB" id="11838at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2810">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3440">
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006644">
        <property type="entry name" value="Cadg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050971">
        <property type="entry name" value="Cadherin-domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059177">
        <property type="entry name" value="GH29D-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF012211">
        <property type="entry name" value="tand_rpt_95"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24025">
        <property type="entry name" value="DESMOGLEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24025:SF23">
        <property type="entry name" value="NEURAL-CADHERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17963">
        <property type="entry name" value="Big_9"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13290">
        <property type="entry name" value="CHB_HEX_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05345">
        <property type="entry name" value="He_PIG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00736">
        <property type="entry name" value="CADG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Dystroglycan-type cadherin-like" evidence="9">
        <location>
            <begin position="650"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="8">
        <location>
            <begin position="669"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="domain" description="Dystroglycan-type cadherin-like" evidence="9">
        <location>
            <begin position="743"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="8">
        <location>
            <begin position="762"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="8">
        <location>
            <begin position="1127"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="domain" description="Dystroglycan-type cadherin-like" evidence="9">
        <location>
            <begin position="1290"/>
            <end position="1383"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="8">
        <location>
            <begin position="1310"/>
            <end position="1384"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="8">
        <location>
            <begin position="1403"/>
            <end position="1477"/>
        </location>
    </feature>
    <feature type="domain" description="Dystroglycan-type cadherin-like" evidence="9">
        <location>
            <begin position="1476"/>
            <end position="1569"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="8">
        <location>
            <begin position="1496"/>
            <end position="1570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIF84707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="1944" mass="197808" checksum="04C841E3D80C21F5" modified="2014-10-29" version="1">MNKKIILAIALLAVMVASMVTIPFAYADSAGPRSGTTFAGNVPIASGDFNWVNPSNAASSDNSYATATVTSSLDISNYLRATGFGFTIPTTAIIQGIEVQIERSEANTQTATIFDNVVSLVKNNVVTGQDKGTSTAWPTTDAIATYGGSSDLWGTTWTPADINNANFGVVLSVGRTSGGNEIARVDHMTITVTYFVPSAQGPQSSSTAAGNIAITSGDANWNNAGNITTSNNLYADVTIQNDADISNYLRATGFGFTIPSTATITGIEAKIERSEGGLGNAEIQDNVVSLVKNNVVTGSNKAVTGTNWPTTDTTATYGSSSDLWGTTWTPADINNANFGVVLSVQSNSNTDESARVDHITMTVYYTLPPNTTPTANAQSLNTDEDTSLPITLTGNANDVGQTLTFEIVTNPSHGTLSGFNSATGAVTYNPAADYNGPDSFAFRVNDGFENSSAATVSITVSAVNDAPVASNQSVSTNEDTALPIVLAATDIDGDLLSYEVVDSPAHGTLSGTAPNLTYTPSANYHGSDSFTFKANDGTVDSNTALVSIIVDSVNDAPTADGQSLTTDEDTAATVTLTGSDVEDGATVTYAVTSGPSHGALSGTAPNLTYTPDSNYNGPDEFKFKVTDTESLDSSEAIVSIAVNAVNDAPALAAIGPQTIGELSELAFNASATDSDLADTLTYSMSGEPTGASIDSSTGAFSWTPTEAQGPGSYTFDVIVSDGNGGTDSENVTVTVNEVNLAPSLTNPGSQSVPEGSPVSIQLLAADGDVPANTLTYAATGLPPWAAIDENTGQITGTPGEADDGTSSVTVTVSDGSVNDSQTFDITVTEVNSAPTASDGAVTTSEDTPANVTLVASDTDIPSNTLTYNVTNPSHGTLSGTAPNLTYTPDANYNGPDSFTFKVNDGQADSNDATVTITIDAVNDAPVADDQNVSSDEDAAKSITLTASDVDGDGLTFSVVDGPSHGVLSGTAPNLTYTPDANYNGTDSFTFKANDGAADSNIATVSITVNAVNDAPTADGQNVATNEDTPTGITLAGSDVEDGTAVTFTVTSGPSHGTLAGTAPNLTYTPDTNYNGPDSFAFTVTDSELLDSAEATVSITVNGVNDAPVASDASATTNEDTPTAAIVLPATDSDGDLLTYEIVSGPSNGVLSGTGDSRIYSPNADFSGSDSFTFKANDGTLDSNTATISITVNAVNDVPLANSQSVSTDEDTPVAITLTGNDTEDGALVNYAVTSSPSHGTLNGTAPNLTYTPDAGYNGPDEFKFKVTDSENADSAEATIAVTVSPVNDAPVLAAIDPQTVNELSELAFNASATDSDMADTLAYSLSGEPAGSSMNSTTGAFSWTPAEAQGPGSYTFDVVVSDGNGGTDSKSVTVTVNEVNSAPVANNNDPVITAEDTPVPITLSATDSDQPANTLTYEIVLGPFDGVLSGTAPNLTYAPSSDFTGEDSFTFKVSDGQADSNEVIVYITVTPANDPPSLAQPADQSVPELALASITMSASDSDVPANTLTFGATGLPSWAAINATTGEITGTPGESDDGTSSITVTVSDGNGGTDSKTFSLTVTEVNSAPTASDGLASTGEGTPVSVTLVASDADLPADTLTYSVVDSPSHGTLSGTAPNLTYTPSANYTGPDSFTFKANDGTLDSNIAAISLAVADTTAPTTTAAPAGGTFVGPQSISLTASEPATIYYTTNGTAPTTSSPVYSSPVSITSTTTLKFFAKDAAGNQESVKTEVYTITAADAVKPTVHISVPANGATINGPTSGVTVNISGTSSDNAGGSGIHIVEMRTETSGYSPVTTADGYANWTKSITFKTAGAHQLVARATDSAGNMQWHVININIGMTIDVTRPVVTVTIPVEGSSLSGPSSGVTVNLQGTSSDNFAVQIVEVRTDTSGYSTAATSDGYAHWTKSVVFKTAGAHQLVARATDSAGNMQWHVVNVNIVFTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVN3</accession>
    <name>A0A075MVN3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03276</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_264357919.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVN3"/>
    <dbReference type="STRING" id="1459636.NTE_03276"/>
    <dbReference type="GeneID" id="75933636"/>
    <dbReference type="KEGG" id="nev:NTE_03276"/>
    <dbReference type="HOGENOM" id="CLU_3245486_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="42" mass="4863" checksum="03543A8B83D19080" modified="2014-10-29" version="1">MSNDITNHFEKAKAQLKSERDSMEQKVKEEIAQSKRKALSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVU1</accession>
    <name>A0A075MVU1_9ARCH</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01356</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700197.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVU1"/>
    <dbReference type="GeneID" id="41597154"/>
    <dbReference type="KEGG" id="nev:NTE_01356"/>
    <dbReference type="HOGENOM" id="CLU_182704_0_0_2"/>
    <dbReference type="OrthoDB" id="378933at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="97" mass="10117" checksum="43CD395263918FAF" modified="2014-10-29" version="1">MSSNARNVKPKVRENKKWGSIAAVTAIMAALVLAAAPSFLQSASAKITEEDTSCENRGGHEPGGQQPSCEGEGLTQNTENQNPAGHAPPGQNDDDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MW09</accession>
    <name>A0A075MW09_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02766</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701316.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MW09"/>
    <dbReference type="STRING" id="1459636.NTE_02766"/>
    <dbReference type="GeneID" id="41598455"/>
    <dbReference type="KEGG" id="nev:NTE_02766"/>
    <dbReference type="eggNOG" id="arCOG08783">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_745145_0_0_2"/>
    <dbReference type="OrthoDB" id="9347at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="378" mass="42616" checksum="18279407E2609AE0" modified="2014-10-29" version="1">MSGKDESIFSKEALMGTQAGKDIMKQGLLRSKGYKQFNQYKEKTEQEFGAFAKRFVMSLHAAINADSSPASTMQKFAEEVSASELVPEAGSISDIKARLSSPNVLQDRVARILNSNFVKMTFPVFNALYDGASEYFGDSPSQEKRDAVIDGHIIAIDLSEPMDRIVDRDEDLEYLEDYKFMNPYILGIARHKISQGGDAVLKAFEEGFKDARLGQYIDVKLKIKPASISDENMNDCYKKYRAVMGTAGRNMALNRRPLGDIFHLGMAKAGEGVGCGNEIEDAIKNGAVKVPSWPLYYALNTGDVRRGFELTMQKSELYLQEAEMAVEMLPENFQLKPFLEFLFLTVRHYNQYWYNELQKRAPFADFQKKIQAVAAVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWA1</accession>
    <name>A0A075MWA1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Urea transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NTE_02894</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the urea transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701420.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWA1"/>
    <dbReference type="STRING" id="1459636.NTE_02894"/>
    <dbReference type="GeneID" id="41598573"/>
    <dbReference type="KEGG" id="nev:NTE_02894"/>
    <dbReference type="HOGENOM" id="CLU_047509_0_1_2"/>
    <dbReference type="OrthoDB" id="7045at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015204">
        <property type="term" value="F:urea transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004937">
        <property type="entry name" value="Urea_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10464">
        <property type="entry name" value="UREA TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10464:SF4">
        <property type="entry name" value="UREA TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03253">
        <property type="entry name" value="UT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="289"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF84932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="371" mass="40086" checksum="6377209CAC7C39A2" modified="2014-10-29" version="1">MAIPTFSTGNPGLDFFFTLFNGISEVPLFSSPITGILILGGVFLASRKAGGMMVLSGLIGAGVAILAGASYDLVTFGLFGYNSILTGMAFWSGPFVKANRATFFISVFGAAITAFTWMAFAHLMGDMFALNGTASSWAIPGFTSSFIFTTWAMMYATKRFGHDIWPAPAPQPKEELIRDSSNPNNTGENFRWTAKEFMIATLKGVSQVTFVENWKTGVFWVVGLTLAFELAPLISGVQDRPWFTNAYTSQWDPFSPLYLAGLMALLGSGIGAAMAILTKLPTAEVRMGLHGFNQVLVMIALTSFVPLTPQSFMMAVFATIGCSFLMPGLQRFFGQWGLPALTGPFVFTAWVFLLATSGFMHIPAGIGWSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWL9</accession>
    <name>A0A075MWL9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribonuclease VapC</fullName>
            <shortName evidence="8">RNase VapC</shortName>
            <ecNumber evidence="8">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Putative toxin VapC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">vapC</name>
        <name evidence="10" type="ORF">NTE_01601</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Toxic component of a toxin-antitoxin (TA) system. An RNase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the PINc/VapC protein family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="8"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700393.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWL9"/>
    <dbReference type="STRING" id="1459636.NTE_01601"/>
    <dbReference type="GeneID" id="41597379"/>
    <dbReference type="KEGG" id="nev:NTE_01601"/>
    <dbReference type="eggNOG" id="arCOG02219">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118482_3_2_2"/>
    <dbReference type="OrthoDB" id="147588at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
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    </dbReference>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Type_II_TA_system_RNase"/>
    </dbReference>
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        <property type="entry name" value="VapC_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33653">
        <property type="entry name" value="RIBONUCLEASE VAPC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33653:SF1">
        <property type="entry name" value="RIBONUCLEASE VAPC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0800">Toxin</keyword>
    <keyword evidence="2 8" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="domain" description="PIN" evidence="9">
        <location>
            <begin position="3"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="5"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00038093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIF83664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="128" mass="14361" checksum="E2FBE3C7D8FBB1A4" modified="2014-10-29" version="1">MACLDTDCLIDLARNDEKAIAKVAELSDSGELLFTTIINVAEYYAGTFRSKTRGAVESARDYLRQFSILVLDEDSVLLWGRLYSELKSSAIGDRDLFIACIALANKQTLLTRNKKHFERVPGLQVEGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
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    <name>A0A075MWM5_9ARCH</name>
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        <submittedName>
            <fullName evidence="1">Zinc-ribbon domain</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="1 2">
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        <lineage>
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            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="KEGG" id="nev:NTE_01606"/>
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    </dbReference>
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            <dbReference type="EMBL" id="AIF83669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="241" mass="26741" checksum="1D84E25A701CC4F6" modified="2014-10-29" version="1">MNFCPNCGAQVPSNAAKFCSGCGSSISGPQIVQQQTVKPTESQVASPKLIGIIKELENDEKVVTQSITQTEVIFVKEAFIKKVLGQERKEVPISISGSMFYLTNQRLIFLKLFELSASELGQDSNLLAGAGGTFYELPLTSITGVEMRQVKLNKNDEARFVNIFGGDVSKLRRPALEIIYDEKAAKGRAKDYMESMMQRGIISKLWGKVEMVYDKIFVLGEQAVVLQPTLSEYVKVKNNMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWN1</accession>
    <name>A0A075MWN1_9ARCH</name>
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        <recommendedName>
            <fullName evidence="3">Sugar-specific transcriptional regulator TrmB</fullName>
        </recommendedName>
    </protein>
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        <name evidence="1" type="ORF">NTE_01611</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
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        <lineage>
            <taxon>Archaea</taxon>
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            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
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            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWN1"/>
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    </dbReference>
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    <dbReference type="OrthoDB" id="7131at2157"/>
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    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="105" mass="12089" checksum="3BE27E9DCC0FBCD9" modified="2014-10-29" version="1">MEKSLLIQYLGDTPKLRIIDFFLENRSDYSKKEIIENTGISKTTFYKVWDDLVQFGIVKETRKYGMAQLYTLDESNPVIKKFMALDAELAKQAMKKATNKLAVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWV1</accession>
    <name>A0A075MWV1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13 16">Phosphoglycerate kinase</fullName>
            <ecNumber evidence="5 13 16">2.7.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">pgk</name>
        <name evidence="17" type="ORF">NTE_01678</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13 16">
            <text>(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13 16">Belongs to the phosphoglycerate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.3" evidence="5 13 16"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700455.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWV1"/>
    <dbReference type="STRING" id="1459636.NTE_01678"/>
    <dbReference type="GeneID" id="41597451"/>
    <dbReference type="KEGG" id="nev:NTE_01678"/>
    <dbReference type="eggNOG" id="arCOG00496">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025427_0_2_2"/>
    <dbReference type="OrthoDB" id="6575at2157"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004618">
        <property type="term" value="F:phosphoglycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1260:FF:000006">
        <property type="entry name" value="Phosphoglycerate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1260:FF:000031">
        <property type="entry name" value="Phosphoglycerate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1260">
        <property type="entry name" value="Phosphoglycerate kinase, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00145">
        <property type="entry name" value="Phosphoglyc_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001576">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015824">
        <property type="entry name" value="Phosphoglycerate_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036043">
        <property type="entry name" value="Phosphoglycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406">
        <property type="entry name" value="PHOSPHOGLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406:SF23">
        <property type="entry name" value="PHOSPHOGLYCERATE KINASE 1, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00162">
        <property type="entry name" value="PGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000724">
        <property type="entry name" value="Pgk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00477">
        <property type="entry name" value="PHGLYCKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53748">
        <property type="entry name" value="Phosphoglycerate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12 13" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="10 13 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13 16" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="13 14">
        <location>
            <begin position="24"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <begin position="62"/>
            <end position="65"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 15">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 15">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 15">
        <location>
            <begin position="357"/>
            <end position="360"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AIF83739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="402" mass="43667" checksum="F04C19E1CA3D4DF9" modified="2014-10-29" version="1">MALRTLTDLDDKKFNGKRVFVRVDFNVSVSNGTVGEDYRIRMTIPTIEYLTKRGAKVILASHLGRPDGRDDDYTLAPVAKRLSEIVGSRPGIKVRFAHDCVGQPVEDEIGRMNNGDILLLENLRFYKEEEANDLKFCKKLASLADIYVNDAFSTSHRKHASTYGMAKLVDARLAGFNMRKEVEYLSMMKDNPIKPFKVVVGGVKIKDKIGALEHLLLKADKVIIGGAAAYTFLKAKGFKTGKSLIDNEHLPWVSKALASYGDKIMLPTDHVAAISPADTSITMVKGDIPDGMAGFDIGSETIERYSTEVSGTNGAGMIFWNGPMGMFEVRAFANGTVNIAKSMALAYWRGAKTLIGGGDTLEAMKKSGVAENEVSHVSTGGGATLRYLAGDEMPGVSVLNGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWV3</accession>
    <name>A0A075MWV3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03098</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701582.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWV3"/>
    <dbReference type="STRING" id="1459636.NTE_03098"/>
    <dbReference type="GeneID" id="41598759"/>
    <dbReference type="KEGG" id="nev:NTE_03098"/>
    <dbReference type="eggNOG" id="arCOG08692">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2695905_0_0_2"/>
    <dbReference type="OrthoDB" id="376485at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="75" mass="8900" checksum="3EE66AFF60777757" modified="2014-10-29" version="1">MSGKEEERQDELRNLLQVVSDKGLRVLSIAELDRLRILLAAKDYSKNKKADRSRKKLLKKINAEMFDRHSPRRFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWX6</accession>
    <name>A0A075MWX6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01718</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWX6"/>
    <dbReference type="STRING" id="1459636.NTE_01718"/>
    <dbReference type="KEGG" id="nev:NTE_01718"/>
    <dbReference type="HOGENOM" id="CLU_2406453_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="99" mass="10473" checksum="0AB2144E002D2C96" modified="2014-10-29" version="1">MHQFALPASGLEILAKSGAIVSAAGVALLVTFVAVLLVFPVAKTCEQEGKKCEYTSSASEQLQPIFSQGFFALSLIVIAAGILMIRYSRWRESKAAAPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MXE9</accession>
    <name>A0A075MXE9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Type II methyltransferase</fullName>
            <ecNumber evidence="8">2.1.1.113</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">N-4 cytosine-specific methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NTE_03263</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = an N(4)-methyl-2'-deoxycytidine in DNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16857"/>
            <dbReference type="Rhea" id="RHEA-COMP:11369"/>
            <dbReference type="Rhea" id="RHEA-COMP:13674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:85452"/>
            <dbReference type="ChEBI" id="CHEBI:137933"/>
            <dbReference type="EC" id="2.1.1.113"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.113" evidence="8"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701723.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MXE9"/>
    <dbReference type="STRING" id="1459636.NTE_03263"/>
    <dbReference type="REBASE" id="90007">
        <property type="entry name" value="M.NevSR1ORF3263P"/>
    </dbReference>
    <dbReference type="GeneID" id="41598918"/>
    <dbReference type="KEGG" id="nev:NTE_03263"/>
    <dbReference type="eggNOG" id="arCOG00115">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024927_2_1_2"/>
    <dbReference type="OrthoDB" id="38200at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015667">
        <property type="term" value="F:site-specific DNA-methyltransferase (cytosine-N4-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002941">
        <property type="entry name" value="DNA_methylase_N4/N6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017985">
        <property type="entry name" value="MeTrfase_CN4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001091">
        <property type="entry name" value="RM_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01555">
        <property type="entry name" value="N6_N4_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00508">
        <property type="entry name" value="S21N4MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00093">
        <property type="entry name" value="N4_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 8 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0680">Restriction system</keyword>
    <keyword evidence="4 8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA methylase N-4/N-6" evidence="9">
        <location>
            <begin position="37"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIF85292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="282" mass="31688" checksum="9D55A052FE23FEF1" modified="2014-10-29" version="1">MNNRPYRVLRYGNDSTATLYLKDCIAGFGDDVREGSVDVVVTSPPYNIGVGYNSYHDSMPREKYLAWIEDVGVAVKRALADDGSFFLNIGNRPKDQWIAWDVASVMRKHFALQNVITWVKSIAIGKADAGNYPGIAGDIAVGHFKPVASERFLNDCYEYIFHFTKHGDAKLDKLAVGIPYQDKSNIGRWKKAKQDRRDRGNTWFIPYETIQSRKDRPHPATFPVKLPEMCIMLHGHARLVADPFTGIGSTALAAKRLGISFVGFEIDKSYLDEAIDRLLLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MXM5</accession>
    <name>A0A075MXM5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MarR family regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_03333</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
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        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0003700">
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HTH_MarR-typ"/>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
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    </dbReference>
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        <property type="entry name" value="Winged helix' DNA-binding domain"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="43"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF85362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="249" mass="27989" checksum="80BB0FD0B98ABDEE" modified="2014-10-29" version="1">MENDADGVAQKLEQQAEGGSQTKEEVVASTSGKQQVLVQNNESEFSAQDLHGNDTKILSLLNEEEGSNYSFKGMMRKLHIHQQSLARALHRLEEMGLVERSQVGYRLSKVGETMVAARATTRRSIIAVPKGREYMQLLQTYIPVDIRPAEIVRALVGKWFRNLRWVGLIESGTGFTLQWASDDGSFQINLRMISDYVVIETNAASQKEKLQAMVGSYAIYEQITKILQDRLAPANAYVLHRPALHQQNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MXQ6</accession>
    <name>A0A075MXQ6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03364</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85392.1"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MXQ6"/>
    <dbReference type="GeneID" id="41599010"/>
    <dbReference type="KEGG" id="nev:NTE_03364"/>
    <dbReference type="HOGENOM" id="CLU_890266_0_0_2"/>
    <dbReference type="OrthoDB" id="387105at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="312" mass="35261" checksum="EA0A909BDE95AFE6" modified="2014-10-29" version="1">MSTENAKNTIPTASESTTNVATMAAKTNVGWYELRPFFEPADNKYPDMHEIIKRIKEFSFFLVRPSKADGVMQLYMHIPDASDAKVAQSALRNALMEPTPRKAFSASMVVYLKMRRHYAIPIAHELVPSLVYATMEKIGRPCFVAVTAKYHDESYQISQFAEKNLYDKPPVWRDILGMFITSFGSDSEKRNLKKHTAPEKLMLAELAKEKQQLRHFHCSIAIGSEEIGAARSIMKVLSESEGFALSSMVRDSVYRMEVVKKPVFFASHFCVLSDIELANIISLPDNPRIYRFNISRKETYTSGPSQAATGEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MXU6</accession>
    <name>A0A075MXU6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Small ribosomal subunit protein eS8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rps8e</name>
        <name evidence="7" type="ORF">NTE_02057</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2 6">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the eukaryotic ribosomal protein eS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MXU6"/>
    <dbReference type="STRING" id="1459636.NTE_02057"/>
    <dbReference type="GeneID" id="41597796"/>
    <dbReference type="KEGG" id="nev:NTE_02057"/>
    <dbReference type="eggNOG" id="arCOG04154">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080597_2_1_2"/>
    <dbReference type="OrthoDB" id="372305at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11382">
        <property type="entry name" value="Ribosomal_S8e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.310:FF:000002">
        <property type="entry name" value="30S ribosomal protein S8e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00029">
        <property type="entry name" value="Ribosomal_eS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001047">
        <property type="entry name" value="Ribosomal_eS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020919">
        <property type="entry name" value="Ribosomal_protein_eS8_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022309">
        <property type="entry name" value="Ribosomal_Se8/biogenesis_NSA2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00307">
        <property type="entry name" value="eS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01201">
        <property type="entry name" value="Ribosomal_S8e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6 7" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF84114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="130" mass="14165" checksum="0C4CAED4F179EA69" modified="2014-10-29" version="1">MRKSIENLAGRKLTGGRKLANRIRRKSEIDRYPNEATVGTTDIVTRRVRGANVKAAFKTAEFANVMDPESKKATKSKILTVTKNPANRDYERRGVVSKGAVIETEAGSALVTSRPGQNGVVNAVLIKAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MYE2</accession>
    <name>A0A075MYE2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein with a von Willebrand factor type A (VWA) domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_02230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700889.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MYE2"/>
    <dbReference type="STRING" id="1459636.NTE_02230"/>
    <dbReference type="GeneID" id="41597950"/>
    <dbReference type="KEGG" id="nev:NTE_02230"/>
    <dbReference type="eggNOG" id="arCOG02900">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_586111_0_0_2"/>
    <dbReference type="OrthoDB" id="10865at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00198">
        <property type="entry name" value="vWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="227"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF84284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="473" mass="53880" checksum="5ADC6B6838A1ED1B" modified="2014-10-29" version="1">MPSPSDKVPPGSKKFVYFALDDDSQSQQQQQQQEKGGSELPKDVLDKLLKAIGREALREKTPSLQELEQSLQNAMSQQMSSEQQGQQQEKEQQQQSSQSGSQVQDGDGMPLVRQLIQKGYLKDSPKWLSSKGFVNIGGRILSDVMKALKAGEYGMHETHDYGQGSIVLDTSKKYEPGDDIRLLNVPKSLLNTIQRSFKDGKEVKLPLQIDMEDFEEYETMQDVRVAIVYCIDLSSTMRYSTMYGDMSRIEAAKRALWSLYLLNRKFFPSDSVYIVGFGALASKVLPQDIPYLKTFEPGSDFLHYTNYQAAFRLASKILQKDGAENKRIVLVTDGHPSACFIDDKSEQDKILSQRPYSHFYTPDKDTLDTVKANQSMNLDVASGELVYLCYRYRQVDQYIGERTIVEAKKCHSMKIDIDTIMISEEDSLLGYVNEMEKYVKGRSYYINPAEIDKVLLTDYLSNKKQQTIRSHSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MZ61</accession>
    <name>A0A075MZ61_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MZ61"/>
    <dbReference type="KEGG" id="nev:NTE_02490"/>
    <dbReference type="HOGENOM" id="CLU_1067943_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="257" mass="28365" checksum="DE3C9AFFD94AE6DA" modified="2014-10-29" version="1">MLPKIIALPLAGAGIIALVTAAFVPFSAWSITTATTGIENNTPVAAAAESKRETKAPESVDDLYPVIKQRWSGSNFTAITNESEASSLAGFDVKFPTRMPSSDYKLQLGIVNRETGDNNKYVFLYCSEKPVTDDMTFNQFWEQGGISVTYHKNATSYVNEYDGNTYTSYSNITAMYEIVVHEYGFDAHLTNVNGHQAIAIADVHREFVPEPYNELEFAVHDPAQVDFVAGNTYVTLQGYKDADELVRIAESIPFDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N034</accession>
    <name>A0A075N034_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glutamyl-tRNA(Gln) and/or aspartyl-tRNA(Asn) amidotransferase, C subunit</fullName>
            <ecNumber evidence="1">6.3.5.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02819</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.3.5.-" evidence="1"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701362.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N034"/>
    <dbReference type="STRING" id="1459636.NTE_02819"/>
    <dbReference type="GeneID" id="41598504"/>
    <dbReference type="KEGG" id="nev:NTE_02819"/>
    <dbReference type="eggNOG" id="arCOG02726">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105899_4_1_2"/>
    <dbReference type="OrthoDB" id="15210at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.60">
        <property type="entry name" value="Glu-tRNAGln amidotransferase C subunit, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036113">
        <property type="entry name" value="Asp/Glu-ADT_sf_sub_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003837">
        <property type="entry name" value="GatC"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00135">
        <property type="entry name" value="gatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02686">
        <property type="entry name" value="GatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141000">
        <property type="entry name" value="Glu-tRNAGln amidotransferase C subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="94" mass="10904" checksum="E45A0C60EACBB93F" modified="2014-10-29" version="1">MTTTAKVTREEVRHLGWLSRIELSDEELAKYTSQIEQIIAYLDRLDTIPLEKAEVIKSKKKFSELRQDEERAFGADTLGTKYRKDGFVKGPRMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N106</accession>
    <name>A0A075N106_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC-type nitrate/sulfonate/bicarbonate transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NTE_03130</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cell membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987037.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N106"/>
    <dbReference type="STRING" id="1459636.NTE_03130"/>
    <dbReference type="GeneID" id="41598790"/>
    <dbReference type="KEGG" id="nev:NTE_03130"/>
    <dbReference type="eggNOG" id="arCOG00169">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046113_1_4_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="entry name" value="MetI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30151:SF0">
        <property type="entry name" value="ABC TRANSPORTER PERMEASE PROTEIN MJ0413-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30151">
        <property type="entry name" value="ALKANE SULFONATE ABC TRANSPORTER-RELATED, MEMBRANE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="MetI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="8">
        <location>
            <begin position="78"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF85164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="278" mass="30261" checksum="341B77AAF4841590" modified="2014-10-29" version="1">MQKETTIHKKVSSNSAKKNSRFDATDAANAFLFIAAFIGVWQLAFSLGIWPKVLMPSPAMVAQTIVGLVADSSLTIGIGVTMWRLFAGFVISVGIGGAVGLAMVKFPSFGKTLSSFAVGLLTFPSIAWVPFSILLISFNDFGILFVLVMASVFSVMISTYSSIRNIPPIYIRAAKNMGASGFSLFRYVMIPAATPSLIIGLRQAWSFAWHALIGAEILITTLYGLGHILQIGREFQDMGQIIAVMIAVFAIGLLFDRLVFVKLEEKVRARWGLDQHSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N110</accession>
    <name>A0A075N110_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701613.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N110"/>
    <dbReference type="STRING" id="1459636.NTE_03135"/>
    <dbReference type="GeneID" id="41598795"/>
    <dbReference type="KEGG" id="nev:NTE_03135"/>
    <dbReference type="HOGENOM" id="CLU_2678685_0_0_2"/>
    <dbReference type="OrthoDB" id="3035at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="74" mass="8077" checksum="1934DB4B89B23BCD" modified="2014-10-29" version="1">MTMMTTSYNKISCRVCGHAFSVAQTCGFCQEPFKWHCRNCGNVDDSTHSHHLADGDSSGNNVVLQTLLVLDNAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLC9</accession>
    <name>A0A075MLC9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00134</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLC9"/>
    <dbReference type="STRING" id="1459636.NTE_00134"/>
    <dbReference type="KEGG" id="nev:NTE_00134"/>
    <dbReference type="HOGENOM" id="CLU_3227625_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="43" mass="4841" checksum="AB5F40525EF429F5" modified="2014-10-29" version="1">MLRIIARIYRELQGVEAAPLGEEGADRAGFSIIFKVQRTFSMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLK0</accession>
    <name>A0A075MLK0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Looped-hinge helix DNA binding domain, AbrB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
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            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
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    <dbReference type="KEGG" id="nev:NTE_00259"/>
    <dbReference type="eggNOG" id="arCOG00818">
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    </dbReference>
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    <dbReference type="OrthoDB" id="8993at2157"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MazE_antitoxin"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <end position="51"/>
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    </feature>
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        <source>
            <dbReference type="SMART" id="SM00966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="94" mass="10701" checksum="A97E3A2D9449487F" modified="2014-10-29" version="1">MVEEGESIVTVTKKGQATIPKALRKKHRIGKKVLVIDTEEGVLIKPVQDPYMEKGSLKALFEDRTSRELVEEAQLEEIKKDRRSLLKEGGKDRQ</sequence>
</entry>
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        <lineage>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="46" mass="5169" checksum="2B378F1C1478AD81" modified="2014-10-29" version="1">MESDLCFSEDNPVAAQVRDGAMSSTGNHTHEELQVVLHGFIHWSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLT4</accession>
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        </recommendedName>
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    </gene>
    <organism evidence="3 4">
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        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
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            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="KEGG" id="nev:NTE_00131"/>
    <dbReference type="eggNOG" id="arCOG14091">
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR046540">
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    <dbReference type="Pfam" id="PF20254">
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="N,N-dimethylformamidase beta subunit-like C-terminal" evidence="2">
        <location>
            <begin position="59"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF82213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="272" mass="31050" checksum="2FC76B5E32B9043D" modified="2014-10-29" version="1">MHHHHLSQEKFFLVNKVKAGINWPQVQFSDAVDALTSMKKKKSFHLGLVVGCCALVIIIFFFILPLSSSLSSYRSHRLLVVIRPTFTFAAYQPHGFYDYYRGNCKTRCLTVPLSPRERTSVMDYAGSNNALEMIKSLETSDVVTDEQVTKNPSILASYQKVIVLHNEYVTQAEFDAITRHPDVLYLYPNALYALVSYNPVSNTITLQKGHGYKGVNDAFNWPPSRSTKDEYNTSCKNWQFEKAVNGIVLNCYPEFDILHDAKLWIAIINRKV</sequence>
</entry>
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    <accession>A0A075MLU1</accession>
    <name>A0A075MLU1_9ARCH</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">NTE_00384</name>
    </gene>
    <organism evidence="1 2">
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLU1"/>
    <dbReference type="STRING" id="1459636.NTE_00384"/>
    <dbReference type="KEGG" id="nev:NTE_00384"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="101" mass="11641" checksum="61E471153D5A3A1E" modified="2014-10-29" version="1">MCTIIRVAFCAEWYTVRDFNSDIFLPNIVMQLDKAIHYKFVRDISVAEKFFLSCKLSHMLNAITPSLMSLLRIVIMRLHLQLLSGYTRDTSALSHDHCTCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLZ3</accession>
    <name>A0A075MLZ3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ammonia monooxygenase subunit C</fullName>
            <ecNumber evidence="2">1.13.12.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
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    </reference>
    <dbReference type="EC" id="1.13.12.-" evidence="2"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLZ3"/>
    <dbReference type="STRING" id="1459636.NTE_00181"/>
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    <dbReference type="eggNOG" id="arCOG08699">
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    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22188">
        <property type="entry name" value="arch-AMO_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Particulate methane monooxygenase subunit c2. Chain: C"/>
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    </dbReference>
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        <property type="entry name" value="NH3_CH4_mOase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04896">
        <property type="entry name" value="AmoC"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AIF82263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="187" mass="21077" checksum="8298FF4C620E9F13" modified="2014-10-29" version="1">MAQMPALIPKEVEVQRLKKIYIMVICLGSIAASVEVDNFVDGSLHQTSIRDSAFTPAHWWLYSHFVALPVGWGMVAIYDRKVPALRGPGNSMNTGLKITILGYLATMFTIGVNEMWHFWFVEEIFAVPNHWMFNMGVVVAFMGALAYVVRVYARLVELGAEMPARNPYVAEMYKLALEGKLYSRSIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MM14</accession>
    <name>A0A075MM14_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">acetate--CoA ligase</fullName>
            <ecNumber evidence="2">6.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NTE_00444</name>
    </gene>
    <organism evidence="9 10">
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        <lineage>
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            <taxon>Nitrososphaerota</taxon>
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.1" evidence="2"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987114.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MM14"/>
    <dbReference type="STRING" id="1459636.NTE_00444"/>
    <dbReference type="GeneID" id="41596320"/>
    <dbReference type="KEGG" id="nev:NTE_00444"/>
    <dbReference type="eggNOG" id="arCOG01529">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_3_6_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003987">
        <property type="term" value="F:acetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001208">
        <property type="entry name" value="PRK00174.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095:SF14">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyl-coenzyme A synthetase N-terminal" evidence="8">
        <location>
            <begin position="36"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="6">
        <location>
            <begin position="96"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="7">
        <location>
            <begin position="531"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF82526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="641" mass="70153" checksum="FE06E24CAE3CB404" modified="2014-10-29" version="1">MEEEEREEPFAFQPGAGHLADSNVARFMKKHDISGYKELVEKANGDISWYWDAVNDDLGLEWFQKYDNVYDSSSAGVPWTKWFVGGKCNIVANAIDRHAKKNPDKIAYIFANERSTRKVTYGELDLEVGRLASALLDAGIKKGDVVGIYLPMVPEAFFAIFACSKIGAVHTTVFSGFSAPALRSRLVDSGARLLITADSAKRRGKDIDLKAQWSQAIEEGTKVERVVTVGGKSAGSNNIVNYGDFVQGKGQARTEVMDAEDPLFILYTSGTTGQPKGTLQVHGGFMAVAAQQAAYLIDLKPDDVLFWYADIGWITGQVWVVYGSPIVGATALVYEEALDYPAPDIWCRLVEKHRVSIFGAAPTAIRLFMKSNVNTDSYDLSSLRVLACTGEPINREAWNWYFDKVGRKKCPVINLSGGTEIGGAILSALPVMPLRPCTVGCPIPGFDADVLDESGRPASEGLLVIKKPWPSMSRGILNDPARFIETYWSRYGKNVWYHGDIVLVDSDGLWYMRGRADDVIKVSGHRIGTAEVEAAAASHPAVAEAVAVGRPDDLKGEIIVICAVIKDGHRPDEGLKSEIAKKVEEAIGRFARPDEVRLVPELPKTRTGKLVRRLVRAKVAGESMSGQDVSTVENPHCLDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MM29</accession>
    <name>A0A075MM29_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00216</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699312.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MM29"/>
    <dbReference type="GeneID" id="41596137"/>
    <dbReference type="KEGG" id="nev:NTE_00216"/>
    <dbReference type="HOGENOM" id="CLU_2597524_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="79" mass="9483" checksum="8E80A2FFE9AFB00C" modified="2014-10-29" version="1">MNYENEHDPSIIRVEKIRTAKPKIMDLVTIRKMWGRSNKLPICNYCGKLISLGDAYFYHSRRKKARKYHWDCAKRINLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MM78</accession>
    <name>A0A075MM78_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00133</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699256.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MM78"/>
    <dbReference type="STRING" id="1459636.NTE_00133"/>
    <dbReference type="GeneID" id="41596074"/>
    <dbReference type="KEGG" id="nev:NTE_00133"/>
    <dbReference type="HOGENOM" id="CLU_138336_0_0_2"/>
    <dbReference type="OrthoDB" id="10202at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="170" mass="18867" checksum="7128FBCAE647CBF7" modified="2014-10-29" version="1">MRNAQWNGLDSSDTIPSSCPYRVDFECTPAPAESLNSLESGRLMLTVKLQGDENKKGEKEKVKAVAVRLVNKAKRENLGNVEGSSELKRKTSLSANLARDNQHTGWWAGVIGIPITWMEGGTTDYERSGSWHPKSKGNLFAMEITYTLDNGSNCTAHFDSEDAYHWTATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMA9</accession>
    <name>A0A075MMA9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative xylanase/chitin deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_00178</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158384900.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMA9"/>
    <dbReference type="STRING" id="1459636.NTE_00178"/>
    <dbReference type="GeneID" id="41596109"/>
    <dbReference type="KEGG" id="nev:NTE_00178"/>
    <dbReference type="eggNOG" id="arCOG02507">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG02876">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG08800">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_349729_0_0_2"/>
    <dbReference type="OrthoDB" id="10393at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059177">
        <property type="entry name" value="GH29D-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003410">
        <property type="entry name" value="HYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13290">
        <property type="entry name" value="CHB_HEX_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02494">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50825">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0858">Xylan degradation</keyword>
    <feature type="domain" description="NodB homology" evidence="4">
        <location>
            <begin position="28"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="3">
        <location>
            <begin position="310"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="281"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="333"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="508"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="628"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="356"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="508"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="631"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF82260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="805" mass="84258" checksum="7D3D936DC68C8C96" modified="2014-10-29" version="1">MAASFLLVLGAISTPLSAQAATIPGACNCVIFRLDDIQDFWLNTVQVALMDHFIEKSEKLTVGTIMNFIGNDPSVVDKVRAGLDSGTFELASHAWNHVDYRTLTPQEQHDTLQQANQKMTSLWGSSAVVFIPPYNAYNDDTLAALQALKMKVISAEFDQELPTIYDPDNPNSKDNKVYKAIPGSNISDSHGIYHLPQVIGFYTYDSEPPTKTAMNTLTSRIDSTISSYGYAVVTLHPQDFAVKDSSQNPTNQISSSELADLDTLIKNIQSKGYAIRTYSQAIGDDNNGSGGGSPSSPPPSSEPPAADDDTDKTAPQITAPADIVKEATGVLTPVSLPSPSVHDDKDPSPHVTNDAPGGGSESGDGANGFPVGTTTVKWNVTDASGNSNSTTQKVTITDTTPPSTPKPLSPKDASKIANGGALRFEWTEATDLASPAVRYDLVVADNPDFKNPAVISQTGLEAPTYNIPPPSGSEPLANGTYYWKVRASDSYGNQSPYSEVSTFIVNSNSSDSSNNGSSNGNNNNGGSTSNSAIALTASPPAGTYSSAQLVTLSANASSSSSATNAVTIYYTTDGSDPAAMTAAVSVYSAPIPIASTTTLKFIARDSSAGNVVAPTVAQEYVIQSVASSSGSSGGGSGGGGGGGGGGSSSGGSFTADGQVFTYADSHFAQHPLDRIQLVTFGTMNLLQNNIVMTSVNPGQPVNISATFKNYQNIPQSYVFITQVEKDGITFSIDWTTGTVNAGQTETASRFWTPADNYDSGNYTVKVFVWDQLSGSPVALSEAGISRISVVAPASAQQQHSELPQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMF2</accession>
    <name>A0A075MMF2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699578.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMF2"/>
    <dbReference type="GeneID" id="41596436"/>
    <dbReference type="KEGG" id="nev:NTE_00570"/>
    <dbReference type="HOGENOM" id="CLU_2490241_0_0_2"/>
    <dbReference type="OrthoDB" id="71090at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="88" mass="10298" checksum="6611E3AFE07CF940" modified="2014-10-29" version="1">MAHVLAKLRDVKFEDVKNMLKADMLKHGEQGLYLKHVWRNADDSGEVLFIFQTNDLSRARKYIESIHAQVLKENPQANLPKMTYLDDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMM7</accession>
    <name>A0A075MMM7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00431</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158384978.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMM7"/>
    <dbReference type="GeneID" id="43502559"/>
    <dbReference type="KEGG" id="nev:NTE_00431"/>
    <dbReference type="HOGENOM" id="CLU_3075495_0_0_2"/>
    <dbReference type="OrthoDB" id="11702at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="58" mass="7139" checksum="F48ADE922908AF8E" modified="2014-10-29" version="1">MKEAAEKMQEEERNAVAGRYTYDDATLEKLQHHFSSYDDLLRYIKRYGMHRHFEHNYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMP7</accession>
    <name>A0A075MMP7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00343</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMP7"/>
    <dbReference type="KEGG" id="nev:NTE_00343"/>
    <dbReference type="HOGENOM" id="CLU_2504795_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="85" mass="9751" checksum="5827907692617CE8" modified="2014-10-29" version="1">MEVSSSRIWLLRNFCHPVCVILQIHDVTTSICIHAHIASVSFSHKQRCMYIALDREMGTCERAIQQEIRSMTTNWSLAALLFSDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMP8</accession>
    <name>A0A075MMP8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATPase component of Mn/Zn ABC-type transporter</fullName>
            <ecNumber evidence="6">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NTE_00033</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="6"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699184.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMP8"/>
    <dbReference type="STRING" id="1459636.NTE_00033"/>
    <dbReference type="GeneID" id="41595985"/>
    <dbReference type="KEGG" id="nev:NTE_00033"/>
    <dbReference type="eggNOG" id="arCOG00201">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_11_2"/>
    <dbReference type="OrthoDB" id="10909at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03235">
        <property type="entry name" value="ABC_Metallic_Cations"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000134">
        <property type="entry name" value="Iron-enterobactin ABC transporter ATP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050153">
        <property type="entry name" value="Metal_Ion_Import_ABC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42734">
        <property type="entry name" value="METAL TRANSPORT SYSTEM ATP-BINDING PROTEIN TM_0124-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42734:SF17">
        <property type="entry name" value="METAL TRANSPORT SYSTEM ATP-BINDING PROTEIN TM_0124-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="6"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF82117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="253" mass="27991" checksum="02A8EDC407DB2E00" modified="2014-10-29" version="1">MHDAVVELEGVSFSYGGTLVLDNITFAVEKGDLLGMIGPNGAGKTTLFSCMLGLLGGYRGTIRIFGEDIKGNSRVFQRIGYIPQRKNIDSNFPATLEEIVSLGIGKSKKGKSDEERIASALGTVGLLALKDRRIGELSGGQQQRVLIAKAIVNEPELLILDEPATGIDLETQNRFYALLKKLNQEQKITIIWSSHDLDAVNKLASRVACVNRSMFFHGETHEFFENPDLLKAYSESSMQAHMHMHDQLHQHDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMR6</accession>
    <name>A0A075MMR6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00641</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699636.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMR6"/>
    <dbReference type="STRING" id="1459636.NTE_00641"/>
    <dbReference type="GeneID" id="41596504"/>
    <dbReference type="KEGG" id="nev:NTE_00641"/>
    <dbReference type="eggNOG" id="arCOG08704">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2379514_0_0_2"/>
    <dbReference type="OrthoDB" id="7874at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="100" mass="10725" checksum="7E8AEBFBE092D465" modified="2014-10-29" version="1">MERAGDNNIPPVTVFVKNADGSEIAAKLSGYFVVRGKEFRFTAIAFGRIGGHNASVKIAKTTLEKIAKMGIDPDALVDTIQRKIVEGDVTLPEGIKPPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNI2</accession>
    <name>A0A075MNI2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ferredoxin--NADP(+) reductase</fullName>
            <ecNumber evidence="2">1.18.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_00630</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ferredoxin--NADP reductase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.18.1.2" evidence="2"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699626.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNI2"/>
    <dbReference type="STRING" id="1459636.NTE_00630"/>
    <dbReference type="GeneID" id="41596493"/>
    <dbReference type="KEGG" id="nev:NTE_00630"/>
    <dbReference type="eggNOG" id="arCOG02200">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1006919_0_0_2"/>
    <dbReference type="OrthoDB" id="35401at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004324">
        <property type="term" value="F:ferredoxin-NADP+ reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06195">
        <property type="entry name" value="FNR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033892">
        <property type="entry name" value="FNR_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051930">
        <property type="entry name" value="FNR_type-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47878">
        <property type="entry name" value="OXIDOREDUCTASE FAD/NAD(P)-BINDING DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47878:SF2">
        <property type="entry name" value="OXIDOREDUCTASE FAD_NAD(P)-BINDING DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF82710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="274" mass="30517" checksum="71AC05EFAB3F20C5" modified="2014-10-29" version="1">MSVQPSLGKLVYRHDLTPDLAIIRIQPSDGSPVPDFRPGQFVTLGLKLDGEDKITNRAYSLSSPPEEKRYFELYIKWAQEPVPGKFTTALFDMKEGDELYWRKPAGAFTMEDKKADGTSDERTLVLVASGTGLAPFVAYVLHLRAIGSKRRIALLHGARNAKELGYRDLFERLAKENSDFIYLPTISRPHEPGSEGWTGHTGRVESLLVPKSDGVSELERALGNRVAPENSFFHICGYSGTIDNVISILQPLGFVSNRNKRKDGSFDIKVETYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNL6</accession>
    <name>A0A075MNL6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ammonia monooxygenase/methane monooxygenase, subunit C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNL6"/>
    <dbReference type="STRING" id="1459636.NTE_00725"/>
    <dbReference type="KEGG" id="nev:NTE_00725"/>
    <dbReference type="eggNOG" id="arCOG08699">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1444620_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22188">
        <property type="entry name" value="arch-AMO_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.50">
        <property type="entry name" value="Particulate methane monooxygenase subunit c2. Chain: C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006980">
        <property type="entry name" value="NH3_CH4_mOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023349">
        <property type="entry name" value="NH3_CH4_mOase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04896">
        <property type="entry name" value="AmoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="184" mass="20918" checksum="91F96EAB7BF8B34E" modified="2014-10-29" version="1">MPALIPREVEIQRLKKIYIMVICLGSIAASVEVDNFVDGSLHQTAIRDSAFTPAHWWLYSHFVALPIGWGMVAMYDRRVPILRGPNNSMNTGLKITIIGYLATMFTIGVNEMWHFWFVEEIFSVPNHWMFNMGVVVAFMGALAYVVRVYARLVELGAETPARNPYVAEMYKLALEGKLYSRSIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNP8</accession>
    <name>A0A075MNP8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00675</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699662.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNP8"/>
    <dbReference type="STRING" id="1459636.NTE_00675"/>
    <dbReference type="GeneID" id="41596533"/>
    <dbReference type="KEGG" id="nev:NTE_00675"/>
    <dbReference type="HOGENOM" id="CLU_1830504_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="140" mass="14750" checksum="0F2680315BE49852" modified="2014-10-29" version="1">MAEPPGSLVINESYSGLDSEQGMAVLDNNQSFYMTTLDGNLKSAFFSEPDGTAVKFAGVTFTFARPLNIPLPSNPMMPVVVQFQDGTSETLFVQVQRDHPMTVLASHGGTIAGITITQGNPLMAGLAGDQGKVKLLVSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNV9</accession>
    <name>A0A075MNV9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sec-independent protein translocase TatA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NTE_00825</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987153.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNV9"/>
    <dbReference type="STRING" id="1459636.NTE_00825"/>
    <dbReference type="GeneID" id="41596669"/>
    <dbReference type="KEGG" id="nev:NTE_00825"/>
    <dbReference type="eggNOG" id="arCOG02694">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086034_3_2_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.3310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003369">
        <property type="entry name" value="TatA/B/E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42982">
        <property type="entry name" value="SEC-INDEPENDENT PROTEIN TRANSLOCASE PROTEIN TATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42982:SF1">
        <property type="entry name" value="SEC-INDEPENDENT PROTEIN TRANSLOCASE PROTEIN TATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02416">
        <property type="entry name" value="TatA_B_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF82903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="111" mass="12436" checksum="10AEC211CBB5430A" modified="2014-10-29" version="1">MAEGISSLIMQFGGLGGAEWIFIIIAIVVVFFGVKKIPEIARSFGKASAEYEKAKIEAKRELQQYKNQENNRVGREKLEEIADSLGINYTNKNDDELRAAIDVELNKSTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MP20</accession>
    <name>A0A075MP20_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NTE_01199</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700064.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MP20"/>
    <dbReference type="STRING" id="1459636.NTE_01199"/>
    <dbReference type="GeneID" id="41597008"/>
    <dbReference type="KEGG" id="nev:NTE_01199"/>
    <dbReference type="eggNOG" id="arCOG01972">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090389_10_4_2"/>
    <dbReference type="OrthoDB" id="35385at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000001">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45663">
        <property type="entry name" value="GEO12009P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45663:SF11">
        <property type="entry name" value="GEO12009P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4 6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Thioredoxin" evidence="7">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="42"/>
        </location>
    </feature>
    <feature type="site" description="Deprotonates C-terminal active site Cys" evidence="5">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <feature type="site" description="Contributes to redox potential value" evidence="5">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <feature type="site" description="Contributes to redox potential value" evidence="5">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="6">
        <location>
            <begin position="39"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF83271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="114" mass="12794" checksum="2C030D31814FA335" modified="2014-10-29" version="1">MSEKQHASNVNLLELAEKNFEETINGSKPVLVDFWATWCGPCQFMLPIFDKLAKKYGDKVTFGRLNVDDNQGVAMRYDVYAIPTFIVFMNGKAIDRAVGAVGEKGLEGLLQKYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MP28</accession>
    <name>A0A075MP28_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid/polyamine/organocation transporter, APC superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NTE_00892</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699831.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MP28"/>
    <dbReference type="STRING" id="1459636.NTE_00892"/>
    <dbReference type="GeneID" id="41596732"/>
    <dbReference type="KEGG" id="nev:NTE_00892"/>
    <dbReference type="eggNOG" id="arCOG00009">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_15_12_2"/>
    <dbReference type="OrthoDB" id="43026at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050367">
        <property type="entry name" value="APC_superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42770">
        <property type="entry name" value="AMINO ACID TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42770:SF11">
        <property type="entry name" value="INNER MEMBRANE TRANSPORT PROTEIN YBAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="428"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF82968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="460" mass="48452" checksum="331F632E849A2768" modified="2014-10-29" version="1">MTGIELKKTSDLRLKQSISLFQAIMYGTGLILGAGIYVLIGDVAGIAGNAMWISFALAAAIATFTGLSYAEMTSIFPKSAAEYVFVKNAFGNNLLAFVSGWLIVFVAVVSAAAVAIGFSSYLDALLPGLDRSVSAILLVAVLSGVNFVGIRESMWMNTTFALIEIAGLAIIICAGLFLASPAATDYFEMPPEVTSSSPSSSFPLALAAIVSAAGLAFFAYFGFENLANISEETKNARKAIPIALVVSIAITTGIYILVAVSAVAIVGWEGLSSTNAPLTFAAEKVFGKAGTVILSSIALFATSNTVLMMLISGSRILFGMATDNALPSSLSEIHPRTKTPFRAIITIMVLTIGVMATSSGRIDAVAKVAVFGIFMVYVFVNLSLIRLRYKQPEMKRPFRSPWSIGKFPVLAGIGIVTSIAMLTQFDLVTVVAGTGAAVSGAVAYEVLKRKYRLPCRNGKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MP36</accession>
    <name>A0A075MP36_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA primase/polymerase bifunctional N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01214</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700078.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MP36"/>
    <dbReference type="STRING" id="1459636.NTE_01214"/>
    <dbReference type="GeneID" id="41597023"/>
    <dbReference type="KEGG" id="nev:NTE_01214"/>
    <dbReference type="HOGENOM" id="CLU_907938_0_0_2"/>
    <dbReference type="OrthoDB" id="11919at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.160">
        <property type="entry name" value="Bifunctional DNA primase/polymerase, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015330">
        <property type="entry name" value="DNA_primase/pol_bifunc_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09250">
        <property type="entry name" value="Prim-Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56747">
        <property type="entry name" value="Prim-pol domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA primase/polymerase bifunctional N-terminal" evidence="1">
        <location>
            <begin position="20"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="306" mass="35078" checksum="35A53B4324D85156" modified="2014-10-29" version="1">MIDLSLSFNEWADFWRNVIGVNVIPADTRNKRTWIKWSQYQDSPISNKQHDEWKATNGFNQGMAVICGKVWHRTDRKHLYLAAIDCDNKIAIEEVLNTNGVTGTIQELAKQHFVEQHKDNPNKAHIYFYTTRPLTKKSSDNTGNTTTGVAVDDNIPALEVKGDGKHGIMYCSPSFHKSGHQYELIGTEEPATLTAAQTSILEQHIDKVCRKYGLKYLENKHGNRSQIPITELFSETFTVSEGSNRHEALMRAMESLIVSFRGKYGEHFVKKICHVWNEEHCRPPLDNTQFEKQWNDAVKFVSKQVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPC9</accession>
    <name>A0A075MPC9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed RNA polymerase subunit Rpo3</fullName>
            <ecNumber evidence="4">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">DNA-directed RNA polymerase subunit D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpo3</name>
        <name evidence="4" type="synonym">rpoD</name>
        <name evidence="6" type="ORF">NTE_01338</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the RNA polymerase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="4"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPC9"/>
    <dbReference type="STRING" id="1459636.NTE_01338"/>
    <dbReference type="KEGG" id="nev:NTE_01338"/>
    <dbReference type="eggNOG" id="arCOG04241">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038421_3_2_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="entry name" value="DNA-directed RNA polymerase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00320">
        <property type="entry name" value="RNApol_arch_Rpo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001514">
        <property type="entry name" value="DNA-dir_RNA_pol_30-40kDasu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022842">
        <property type="entry name" value="RNAP_Rpo3/Rpb3/RPAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050518">
        <property type="entry name" value="Rpo3/RPB3_RNA_Pol_subunit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001988">
        <property type="entry name" value="PRK00783.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800:SF2">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="Insert subdomain of RNA polymerase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00446">
        <property type="entry name" value="RNA_POL_D_30KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 4 6" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4 6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RpoA/D/Rpb3-type" evidence="5">
        <location>
            <begin position="47"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF83406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="250" mass="27533" checksum="23AF101EB7741FAC" modified="2014-10-29" version="1">MYLCVSTPSSCKPIIFASFGRFLRTFWELPEVLASPSVEVVEKSDNRIVVKFNNIPRQYVNALRRLAISEVPTLAIDDVVILENSSVMHDEAVAHRLGLIPLRTDPGRFVMPHECDCGSTLGCSKCRVLLVLDAEATDKTKVVTSGEMVSEDEMVKPVSKDIPIVVLAPSQKLKFEAYARLGVGKQHAKWQPTSAAVVKDGKDESEIVLIIETNGALTAEEILKESTERLQSKIKNFKQVIGSLKVPKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPM9</accession>
    <name>A0A075MPM9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">EVE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01016</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699923.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPM9"/>
    <dbReference type="STRING" id="1459636.NTE_01016"/>
    <dbReference type="GeneID" id="41596840"/>
    <dbReference type="KEGG" id="nev:NTE_01016"/>
    <dbReference type="eggNOG" id="arCOG08640">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041799_2_1_2"/>
    <dbReference type="OrthoDB" id="35872at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd21133">
        <property type="entry name" value="EVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.590.10">
        <property type="entry name" value="ph1033 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052181">
        <property type="entry name" value="5hmC_binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002740">
        <property type="entry name" value="EVE_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047197">
        <property type="entry name" value="THYN1-like_EVE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14087">
        <property type="entry name" value="THYMOCYTE NUCLEAR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14087:SF7">
        <property type="entry name" value="THYMOCYTE NUCLEAR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01878">
        <property type="entry name" value="EVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EVE" evidence="1">
        <location>
            <begin position="2"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="134" mass="15298" checksum="EEBCD55D42AA6F00" modified="2014-10-29" version="1">MAYWLFKQEPSTYNYAQLEKDGRTVWDGVANNLALKHLRSVKKGDRAIFYHTGDEKQAVGIIDIVSDPYPDPKEKDESLVVVDVKPAGRLKKPVALEKIKSDPAFAQWELVRVSRLSVMPVPKKLWERIMKMSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPQ7</accession>
    <name>A0A075MPQ7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01115</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPQ7"/>
    <dbReference type="STRING" id="1459636.NTE_01115"/>
    <dbReference type="KEGG" id="nev:NTE_01115"/>
    <dbReference type="HOGENOM" id="CLU_2243699_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="104" mass="10594" checksum="370DAB7DAA0B4038" modified="2014-10-29" version="1">MALLKTIATATRIKAPAATGIMNQAREPASVTAVDAKNAVAPAGGCVSLRICIAKIETATEMAIKTYFSPPAKYAACSRATAAPINPDRTCPTTVLRGCASGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPV8</accession>
    <name>A0A075MPV8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribonuclease HI</fullName>
            <ecNumber evidence="2">3.1.26.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.26.4" evidence="2"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700343.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPV8"/>
    <dbReference type="STRING" id="1459636.NTE_01538"/>
    <dbReference type="GeneID" id="41597323"/>
    <dbReference type="KEGG" id="nev:NTE_01538"/>
    <dbReference type="eggNOG" id="arCOG02942">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095977_0_0_2"/>
    <dbReference type="OrthoDB" id="52651at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd09279">
        <property type="entry name" value="RNase_HI_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053576">
        <property type="entry name" value="RNase_HI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041175">
        <property type="entry name" value="RNAseHI_Thmprot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46387">
        <property type="entry name" value="POLYNUCLEOTIDYL TRANSFERASE, RIBONUCLEASE H-LIKE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46387:SF2">
        <property type="entry name" value="RIBONUCLEASE HI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13456">
        <property type="entry name" value="RVT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="10"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="164" mass="18191" checksum="793E75DBC8EA1C78" modified="2014-10-29" version="1">MPVSKTTTTDNIVIEVHFDGLCLPKNPGGIACYAYIIKEKGSGRLLHSDSGIAAEPSAQSTNNVAEYTALIRALEWLDENGHASRKVEVKGDSQLVVKQMSGEFRVKHKQIIPLFQRAALLRKKFADISITWVPREQNSEADKLSERAYNNALLENPGLLDMIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPX7</accession>
    <name>A0A075MPX7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NTE_01563</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987223.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPX7"/>
    <dbReference type="STRING" id="1459636.NTE_01563"/>
    <dbReference type="GeneID" id="41597345"/>
    <dbReference type="KEGG" id="nev:NTE_01563"/>
    <dbReference type="eggNOG" id="arCOG04397">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_33_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029:SF10">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="17"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="384"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="451"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="9">
        <location>
            <begin position="84"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIF83626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="508" mass="53406" checksum="F31D3E9777F10169" modified="2014-10-29" version="1">MNADDSKAKSLLLSSRLGLASLAAVVMALVAVGYTGSAFAYAPDDPAVPFHCWQTNEDGTKKIVTGEDGSQSLVPCEVNAGDNAWMLTSSALVLMMTPAGLAMFYGGLARQKNAVNVLHMVFITTGVIGVQFALWGYSLAFGPDAGGYGFIGTLDWVGLQNVLHDVPSNAYGGITGFTIPHQTYMIFQMMFAIITPALIVASVAERMKFSAFIIFIVIWATFVYDFAAHWTWEITAPDNYGRNPGYCNFGWGGCLGALDFAGGTVIHITSGWSGLVIALMLGRRLGYGKVPMEPHNVSLVVLGAALLWTGWFGFNAGSAAAAATNATSAFVATQIATGMAAVTWALISWAHTGRPSTIGAASGAVAGLVAITPASGFVSPMSSIIIGILASIICYSAVSFKNKRKWDDALDAWGVHGVGGLAGAILTGIFAEKRFTPWGDNGLAFGNPAQLYENAVGAFAALAWAMGLTAVIIKIMDVVWPGGIRVTPKEEEVGLDLSQHGERAYVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPZ5</accession>
    <name>A0A075MPZ5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rieske Fe-S protein</fullName>
            <ecNumber evidence="7">1.10.2.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NTE_01578</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.10.2.2" evidence="7"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700374.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPZ5"/>
    <dbReference type="STRING" id="1459636.NTE_01578"/>
    <dbReference type="GeneID" id="41597358"/>
    <dbReference type="KEGG" id="nev:NTE_01578"/>
    <dbReference type="eggNOG" id="arCOG01720">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1478847_0_0_2"/>
    <dbReference type="OrthoDB" id="5623at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014349">
        <property type="entry name" value="Rieske_Fe-S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01409">
        <property type="entry name" value="TAT_signal_seq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10134">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="6">
        <location>
            <begin position="76"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF83641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="204" mass="22708" checksum="C1FEB842B79E11A0" modified="2014-10-29" version="1">MAQTPPPPIGGKVSRRDFLKLMAAAGTVMTFTPFVDWGKFLPNPTGNLSERQPVELPSGEQANVKDFPVNHSEAIIYPKTKDEVLNKEAFRTWQFIRLPEELGGAKNDASAFRVYSMVCLHLWCLWKYFPDTGRKRGECPCHGSMYDPMTGKAFAGPASLQGPPSNVLPRLDVEVDKDGKVWILPPTWSPDKNGIVGYGRFLNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQ72</accession>
    <name>A0A075MQ72_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700120.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQ72"/>
    <dbReference type="GeneID" id="41597069"/>
    <dbReference type="KEGG" id="nev:NTE_01264"/>
    <dbReference type="HOGENOM" id="CLU_201544_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="72" mass="8060" checksum="C72F57A26270F2FA" modified="2014-10-29" version="1">MSGQNIPENDKEEEIAELRSLGVDPKRKTGLDDKKELKELADIIKQSMLQDYKTAYSKKGSKFEQEAGSAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQ93</accession>
    <name>A0A075MQ93_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01167</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700037.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQ93"/>
    <dbReference type="GeneID" id="41596979"/>
    <dbReference type="KEGG" id="nev:NTE_01167"/>
    <dbReference type="HOGENOM" id="CLU_1307772_0_0_2"/>
    <dbReference type="OrthoDB" id="383105at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="210" mass="23710" checksum="162C11231D1DC7A9" modified="2014-10-29" version="1">MLPKTVQEFYPFAVHTIYAVIITLSFEVASHLLIPIENVFSSWDNILRSAGLMLAYIIIISGWIGYTKSISKRPHSENHLGNARFVMDLVILFLVFYLMSFANEEDVPGVITDKLPANVIMKINSIVTIQEFVYFFASFRYALATTYFALKDAQKIAPPPYIVGSYLYDIVAAWNLTHHREPLTLGYMMAATEQIANNAADVHADAACYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQB0</accession>
    <name>A0A075MQB0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Selenocysteine lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_01188</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700054.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQB0"/>
    <dbReference type="STRING" id="1459636.NTE_01188"/>
    <dbReference type="GeneID" id="41596998"/>
    <dbReference type="KEGG" id="nev:NTE_01188"/>
    <dbReference type="eggNOG" id="arCOG00065">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003433_2_1_2"/>
    <dbReference type="OrthoDB" id="5817at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43586">
        <property type="entry name" value="CYSTEINE DESULFURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43586:SF8">
        <property type="entry name" value="CYSTEINE DESULFURASE 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="2">
        <location>
            <begin position="22"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF83260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="393" mass="42416" checksum="DE267C00476BCF31" modified="2014-10-29" version="1">MTAVQDASPDLRLDFPITKKTIYMNNGAVAPTPLAVVKATTDFMVKCADEGPDAQATSDYITSLLKELRTRVAHLINCEPEEVVLTQSTTEGINIVANGISWKKGDTIIARGGKHEHPANYLPWLRLSQKGTIASLKELVIDENGFFDLAELEKAAKGSRLVTMSHALYNTGAIMPLEEVGSIVAGENNALFCVDAAQTAGTIKIDVKKIGCHFMAFPGFKWLCGPMGIGVLYCSKKAAEALEPPSIGGESAIVSDSGIIAAREMPHRLQTGFRNYPGAAGLEAALRYVLRVGIDNIRSANMKVAEALREELGRIQGVTLYGPQDAEKRTSIVTFSVPKDPSMIVRKLEEENRIVLAEREAGGRRKIIRAAPHFFNTEAEAATVAAQIKALLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQD1</accession>
    <name>A0A075MQD1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DNA helicase, Rad3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NTE_01675</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQD1"/>
    <dbReference type="STRING" id="1459636.NTE_01675"/>
    <dbReference type="KEGG" id="nev:NTE_01675"/>
    <dbReference type="eggNOG" id="arCOG00770">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033880_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF34">
        <property type="entry name" value="REGULATOR OF TELOMERE ELONGATION HELICASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="1"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIF83736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="558" mass="64500" checksum="DB51BDF5A49ECD71" modified="2014-10-29" version="1">MREKQRSVLLEIESALKSGYRNIFLEAPTGFGKTPVAITLARYLGSSHICTATKDLQAQYQRDFPFVFEVKGRANFPCIVKEDMGLAENCDFGPCVQDDSYDCMYKTRLLDYKVVGEGTLAEQVRLDPLAEKTYVDKLKKQSKIVELEWRPCHYFHQRWIGAKASHTVYNYRYFLSDIFYTGTTQKRKLLVMDEAHQIESEVGDFRSFTVHKNTLRFLPRVQMPEKNVEDVEPWMEFCSSLRDKMIKFIEQATDAIERGRVAEPYTERNLIEAISKEKNLEAVLYDMRSNKKNWIVSSIQRDAQNQQLVRATLTPLETSGYFGDILDKGTINLFMSATILSKDYLCKVSGLKPDQVKFIQVRDSDFPVKNRPIHLMNVAWLNARSMQESMPKIAKAVDNIMTIHKNEKGIIHTTSYSQLQYIRDNISRENASRLIETGSALGREEVLEKHYKSARPTVLISPSLHLGVDLKDDLSRFQVITKVPYPDLTDRKVSAMKDRDQRWYTWYTVLRLAQSYGRSIRSADDFATTYILDSSISFLLKNAQDMVPKWFMEAVKNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQQ2</accession>
    <name>A0A075MQQ2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQQ2"/>
    <dbReference type="STRING" id="1459636.NTE_01805"/>
    <dbReference type="KEGG" id="nev:NTE_01805"/>
    <dbReference type="HOGENOM" id="CLU_118893_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="198" mass="21478" checksum="CF9D16573DBF5692" modified="2014-10-29" version="1">MCLILSALLSSIPTLFLIPAYAAVDSSLVSGTSLEGADVQVEALGPIKFDEPNQPIPYLANGTDYTFIVSFFEPNSRKLLKDVNYNIVITDNPFGPGNELFNAAKQANDPSNMMLHSATGNATVKYNFNKPQTAILRIQFYGTANNATSSGQQQPQQHDFEYQVIDSKAMPEFPLIAVVLASSLVAAIVVARTHIKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQR5</accession>
    <name>A0A075MQR5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HEPN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01362</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385173.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQR5"/>
    <dbReference type="GeneID" id="41597160"/>
    <dbReference type="KEGG" id="nev:NTE_01362"/>
    <dbReference type="HOGENOM" id="CLU_881718_0_0_2"/>
    <dbReference type="OrthoDB" id="377412at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.330">
        <property type="entry name" value="Nucleotidyltransferases domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007842">
        <property type="entry name" value="HEPN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05168">
        <property type="entry name" value="HEPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81593">
        <property type="entry name" value="Nucleotidyltransferase substrate binding subunit/domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HEPN" evidence="1">
        <location>
            <begin position="5"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="315" mass="36809" checksum="44CC67DE4EE8633F" modified="2014-10-29" version="1">MLWYDFLTQAKKDMYRARLLHLEADYGFAAYSCQQGLEKYLKAYLLKHKAIEKARDISHADMTKLFYIIDKKVKAFLDKHRTTPIVSDVILQDAKKKLNDLLEALQPNQKVNEEDRLMTKTQLWKYSLQQPVDQSYESRFRIKKELLKESLGPVGLGFKKNFENAIIHDLARIPTEYKRITAQRYTSESSHFSKSLIQLIEGKLPEFSAEESNRCMIAFMEYMEAGLKKGGYYKTADVWLERKMIYLLVYPYDFYTSITKTYPHEDIGRYPTPIGEKSSLDLYPLYAENLSSLISEVESDCAKIENAIYGKWDKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQV7</accession>
    <name>A0A075MQV7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01871</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQV7"/>
    <dbReference type="STRING" id="1459636.NTE_01871"/>
    <dbReference type="KEGG" id="nev:NTE_01871"/>
    <dbReference type="HOGENOM" id="CLU_3387395_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="32" mass="3660" checksum="3BE5256A91E357BA" modified="2014-10-29" version="1">MIKRFKIKKFSLIKSEDVTYLASAYCTGAMCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQX3</accession>
    <name>A0A075MQX3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PKD domain protein,putative calcium-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_01436</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQX3"/>
    <dbReference type="STRING" id="1459636.NTE_01436"/>
    <dbReference type="KEGG" id="nev:NTE_01436"/>
    <dbReference type="eggNOG" id="arCOG02482">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG07781">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_410860_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00146">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.150.10.10">
        <property type="entry name" value="Serralysin-like metalloprotease, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018511">
        <property type="entry name" value="Hemolysin-typ_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001343">
        <property type="entry name" value="Hemolysn_Ca-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022409">
        <property type="entry name" value="PKD/Chitinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050557">
        <property type="entry name" value="RTX_toxin/Mannuronan_C5-epim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011049">
        <property type="entry name" value="Serralysin-like_metalloprot_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38340">
        <property type="entry name" value="S-LAYER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38340:SF1">
        <property type="entry name" value="S-LAYER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00353">
        <property type="entry name" value="HemolysinCabind"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00801">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00313">
        <property type="entry name" value="CABNDNGRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00089">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51120">
        <property type="entry name" value="beta-Roll"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="PKD domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00330">
        <property type="entry name" value="HEMOLYSIN_CALCIUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="PKD" evidence="3">
        <location>
            <begin position="303"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF83500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="670" mass="69551" checksum="B40E62CF754A042D" modified="2014-10-29" version="1">MIFLNYSGVRKCLFYNLHKVFFYVMSNYNPRLKRRGSYRRETSAAPGIATALVLLLSVIAIPSLVLAASGPAVTMRVWSPGPGVISMGTPVTFRATGTDDDLAVQGFEWDFDGNGEPDAYSAADSPGKSSSGSIVRTFSAPATAYPAVRAVNSEGFVSAWDVYDVNGLPIQLVIGSSAPPKVTMNRWSPYSAAGPDGSPATSFTFSASASSDEGLARVEWDFDGDGNVDATSQVSGKSSISATVDHVYGSPGSWVPKVRAVDVNDLPSLWAAYAVNGATAKQETTITLDVAIPELAATLTFSQEGPTTSTGANGSPSATYAFSVTSSANLTGYEWDFDGDGTVDATTSTPATQHTYRKYGLFLPTVTVNDAFGTRALVLPVGLNGRPAYIGVLGEAPVASMDQWSPFSAKGADGRTGMAFTFSAGASAQGGVQKFEWDFDGDGGIDLITAVEGAPASATATASYTFDREGNFTPQVRAVDATNQTSPWAFYGSSNAVHLDVAASYSQSAQPTAEKPLTEEKYCGGMTIEELIASGKYNVVDKRDSGQKMIFGTRGADLIIGSGAQNVILGRAGNDCIITGGGDDYAFGNEGDDIIFGSEGRDTINGGPGDDLIYGMAGNDSIKASSGDDKANGGLGNDTINGGAGNDWCYGGGGNDADKAISCETSAPFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MR38</accession>
    <name>A0A075MR38_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Molecular chaperone (Small heat shock protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_01605</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700396.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MR38"/>
    <dbReference type="STRING" id="1459636.NTE_01605"/>
    <dbReference type="GeneID" id="41597383"/>
    <dbReference type="KEGG" id="nev:NTE_01605"/>
    <dbReference type="eggNOG" id="arCOG01832">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046737_12_4_2"/>
    <dbReference type="OrthoDB" id="198277at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031107">
        <property type="entry name" value="Small_HSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11527">
        <property type="entry name" value="HEAT-SHOCK PROTEIN 20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="4">
        <location>
            <begin position="58"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF83668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="171" mass="20167" checksum="6DE0949B3E9D97BD" modified="2014-10-29" version="1">MSSKGEREPKREEENSSTAIAPRRFENMFDNFRRDMERMMRPWPLATMSWPDMPSLFEARDMRMALYDLVDKGDRYELQVEVPGIEKEKIDVKATRYTVEISGKHSEKTEEKGKRYLYTERLYRSFYRNVPVPEEIVPSKVNAKVDNGILKLELPKKVPTKGEEETKVDVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MR73</accession>
    <name>A0A075MR73_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700101.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MR73"/>
    <dbReference type="GeneID" id="41597048"/>
    <dbReference type="KEGG" id="nev:NTE_01242"/>
    <dbReference type="eggNOG" id="arCOG01580">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_170329_2_1_2"/>
    <dbReference type="OrthoDB" id="6762at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription regulator AsnC/Lrp ligand binding" evidence="1">
        <location>
            <begin position="16"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="80" mass="8515" checksum="04A21D55A26AF2E7" modified="2014-10-29" version="1">MTLAFIFVNCNVDGGSAAEKNVKKVKGVVESHSTSGAYDLILKVKAETESELRDIIKNIRKVTGVVAAITSIVYGSDQAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MR84</accession>
    <name>A0A075MR84_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Fe-S oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01252</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148702046.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MR84"/>
    <dbReference type="STRING" id="1459636.NTE_01252"/>
    <dbReference type="GeneID" id="41597058"/>
    <dbReference type="KEGG" id="nev:NTE_01252"/>
    <dbReference type="eggNOG" id="arCOG02579">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1444715_0_0_2"/>
    <dbReference type="OrthoDB" id="36424at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005358">
        <property type="entry name" value="Puta_zinc/iron-chelating_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35866">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35866:SF2">
        <property type="entry name" value="YKGJ FAMILY CYSTEINE CLUSTER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03692">
        <property type="entry name" value="CxxCxxCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="202" mass="22262" checksum="72397DB5E57C3C7A" modified="2014-10-29" version="1">MHNTTTRRKQQPVKKKFACVQGCSDCCIYREYYPSPDFGKIGVLLLPEEKGKMEKLAKEKGIEIRIVPRLAVGGTAGPEKIIAYQMMGKQKDGDLCPFLDLEKPSPHGGFACGIYAQRPLACSAYPVVDAGSKDVTLDPHCQFCKHNHNYSTKASLEGLENELESLSKIKAAVKAENGVHVWRYATATGEQATLDEGWVLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MR92</accession>
    <name>A0A075MR92_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Type II methyltransferase</fullName>
            <ecNumber evidence="8">2.1.1.113</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">N-4 cytosine-specific methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NTE_01552</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = an N(4)-methyl-2'-deoxycytidine in DNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16857"/>
            <dbReference type="Rhea" id="RHEA-COMP:11369"/>
            <dbReference type="Rhea" id="RHEA-COMP:13674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:85452"/>
            <dbReference type="ChEBI" id="CHEBI:137933"/>
            <dbReference type="EC" id="2.1.1.113"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.113" evidence="8"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700354.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MR92"/>
    <dbReference type="STRING" id="1459636.NTE_01552"/>
    <dbReference type="REBASE" id="90017">
        <property type="entry name" value="M.NevSR1ORF1552P"/>
    </dbReference>
    <dbReference type="GeneID" id="41597334"/>
    <dbReference type="KEGG" id="nev:NTE_01552"/>
    <dbReference type="eggNOG" id="arCOG00115">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024927_2_2_2"/>
    <dbReference type="OrthoDB" id="38200at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009007">
        <property type="term" value="F:site-specific DNA-methyltransferase (adenine-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015667">
        <property type="term" value="F:site-specific DNA-methyltransferase (cytosine-N4-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002941">
        <property type="entry name" value="DNA_methylase_N4/N6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017985">
        <property type="entry name" value="MeTrfase_CN4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001091">
        <property type="entry name" value="RM_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13370">
        <property type="entry name" value="RNA METHYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13370:SF3">
        <property type="entry name" value="TRNA (GUANINE(10)-N2)-METHYLTRANSFERASE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01555">
        <property type="entry name" value="N6_N4_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00508">
        <property type="entry name" value="S21N4MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00093">
        <property type="entry name" value="N4_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 8 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0680">Restriction system</keyword>
    <keyword evidence="4 8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA methylase N-4/N-6" evidence="10">
        <location>
            <begin position="80"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIF83615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="313" mass="34640" checksum="AF19E438C94820EA" modified="2014-10-29" version="1">MVAGTKKARRAPTSTSGFGVSRRESHDSSQFYSRRLYSDGNDNGSDSKPEEKENNVPAKALDRIFCKSSESMDELPDKSVHLAVTSPPYNVGKEYDGDLTMEQYRGLLRSVFSELYRVLVDGGRACINVANLGRKPYIPLHSYVIQDMLACGFLMRGEVIWNKGSSAGTSTAWGSWQSASNPTLRDVHEYVLVFSKGSFSRDKKPSGVSNNKSTISKEEFLEYTKSVWEFQAESAKKVGHPAPFPVELPYRCIQLYTFAGDVVLDPFCGVGSSCIAALKAGRHFVGYDTSQEYVQAAQARLRTFMQQKGNIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MR99</accession>
    <name>A0A075MR99_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HNH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01273</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MR99"/>
    <dbReference type="STRING" id="1459636.NTE_01273"/>
    <dbReference type="KEGG" id="nev:NTE_01273"/>
    <dbReference type="eggNOG" id="arCOG03899">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_176748_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002711">
        <property type="entry name" value="HNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01844">
        <property type="entry name" value="HNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNH" evidence="1">
        <location>
            <begin position="15"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="83" mass="9543" checksum="2DB9714F007EBFEB" modified="2014-10-29" version="1">MAIRQTVLERARGRCQKCSTKFSPSVEPHFEHINGSKKDNRPQNLRALCPSCYRAVEERENKKKGVLGGLRKAFDKVPVDFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRH1</accession>
    <name>A0A075MRH1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700774.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRH1"/>
    <dbReference type="GeneID" id="41597824"/>
    <dbReference type="KEGG" id="nev:NTE_02090"/>
    <dbReference type="eggNOG" id="arCOG00374">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG03888">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_512536_0_0_2"/>
    <dbReference type="OrthoDB" id="375928at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="531" mass="57602" checksum="AC06847F00A00F59" modified="2014-10-29" version="1">MQTKFLRREYWLPPLAVLFFLAGSSLVFAQETPKAEMCNADICYIKITGDGFSPSRLVVRDGSTVIWKNVDSSAHMIAGGPAENPALFNSSLLSSGRDYAFVFNGGLDGKFTYLDQSRNNVAGEIVVAPRALEDPVKQVSIDFADPSSGLKIEMAQGNVTAATAIPQLHRMTIWIGDAPGPGMLKVTVDRRLLDSQAMGADTPFEVLVAGNSNSDDDKPANYKEILPATPAQRTLVVPVAEGTKSVTIVGRQMSVDMLGYSEAQAALERAEKAIAEFRGNGVVVSDAEGMLLNAHDAFAGGKYRFAKSLADEATDLASSINRTAQAAKQATNVAEVSIKNTKALGIPVPEAEEMLQRTKEMYLHGGYDDALSMAVQAKMAAADPANQFYMAAGIASVSAGWVVVYMRLRHKGIARAKAANEETGPVSIDVKGGSAPVEMQQQLAPQIATTAITVMDLDRVFAQKPHIRSSDRDVLKYVMEQNHGEVLLADIRNRFLLPKSSAWRLVKRLEREELIEIIKFGNQNLIRCRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRH7</accession>
    <name>A0A075MRH7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02096</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700778.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRH7"/>
    <dbReference type="GeneID" id="41597829"/>
    <dbReference type="KEGG" id="nev:NTE_02096"/>
    <dbReference type="HOGENOM" id="CLU_2519586_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="84" mass="9606" checksum="C4E131A3A2B56DC7" modified="2014-10-29" version="1">MNRLSITLNDFLEEKLRGIQGDLIKGRKQDISFTTVVNMVLLGGILGSRYLKKDDWQAIKDFLDDQQINLDAEGLTDNYVNMTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRI2</accession>
    <name>A0A075MRI2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02101</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700783.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRI2"/>
    <dbReference type="GeneID" id="41597834"/>
    <dbReference type="KEGG" id="nev:NTE_02101"/>
    <dbReference type="HOGENOM" id="CLU_1207574_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="229" mass="26318" checksum="0FD0E060A1E7E4CD" modified="2014-10-29" version="1">MTLTDDLAEKHEKDIELMQRMYLEAERQFVEFNFIVPYVDNDDQVYSPRLVSLLQVIGSQIDGILKILAGLLSIDVKRVTKKKQPAFTDYTQVIDRHGLLSVQQIRFKENGKVLTPFKFDSSHTTDWRKALNDTKHELPKGAYSGQYGHVVNSIAALAILHELVNTATHDDFRPYILNSKNWFDNGVSMRSLGLQKSHDFCRKKSQVFEYAMWFTLSELTPTLPEPSGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRJ2</accession>
    <name>A0A075MRJ2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02106</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385362.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRJ2"/>
    <dbReference type="STRING" id="1459636.NTE_02106"/>
    <dbReference type="GeneID" id="43502639"/>
    <dbReference type="KEGG" id="nev:NTE_02106"/>
    <dbReference type="HOGENOM" id="CLU_3075139_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="52" mass="5689" checksum="DD7B26ED3FD8BE02" modified="2014-10-29" version="1">MASTDTESLEVAVVGKLVPNEGRYLISISKDYAEALARITTKRVLIRVTPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRM1</accession>
    <name>A0A075MRM1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRM1"/>
    <dbReference type="KEGG" id="nev:NTE_01400"/>
    <dbReference type="eggNOG" id="arCOG04625">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2613762_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="92" mass="10710" checksum="8BF211ECE363CF28" modified="2014-10-29" version="1">MPERLAVRQRVIILPAFGGKRFPRAARRARKPMQDKWPKVPKGKWLKCTYGRCGHEWQYFGGHSWAECPLCHTTSKVAIAIRNYKENKSNRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRP8</accession>
    <name>A0A075MRP8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Zinc-ribbon domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01694</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRP8"/>
    <dbReference type="STRING" id="1459636.NTE_01694"/>
    <dbReference type="KEGG" id="nev:NTE_01694"/>
    <dbReference type="HOGENOM" id="CLU_629494_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026870">
        <property type="entry name" value="Zinc_ribbon_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13240">
        <property type="entry name" value="Zn_Ribbon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zinc-ribbon" evidence="1">
        <location>
            <begin position="471"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="493" mass="54407" checksum="DA13ADFAAF24EEC9" modified="2014-10-29" version="1">MRCRSAKEIIYSIYTINPEDVSLLEAAQLITRGSITFQSTTKDAVFDAFLLSCKQAGADIKSADRTTYRIDGKSGTMWLQNRFSFRFHARLVGDDNGGGSQGVRLEVYDFAPSPPDKRFIEKLLKKVVDKIPGGKLEYNLDCVEQPGDAPVVPAKNTAAPIAIVSKGQLMADARMIPTFEYSLQGATGDDGSVHGADKLIIMPPECGNVLSLYKGASLVLGIAISSIEKMMPVMAEKKGLLGKKGDLSLDILYNDGSGGVHSVRVNVDDEKGGEIVDKVNRFEKIQKEQDIYYDFEYLENGQWLPDRLYPATLFLAKCEKLVWLKQDTAGVFSKHYKWIKALTNIRVFYYNFESRAVDAMALSMVQDVTVINKRKESVSRSSGTIDQRERGSYTTGHFQSARDTTTVTVGDVAFMYNGAPRITFVDVEDPDGLATLAREAIANSKFTFRLKPQQWQPAGKSPSAQQNAEACPKCNAQNLPGSNFCAKCGFTLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRW2</accession>
    <name>A0A075MRW2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01848</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRW2"/>
    <dbReference type="KEGG" id="nev:NTE_01848"/>
    <dbReference type="HOGENOM" id="CLU_1006857_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="276" mass="32533" checksum="18F8E74D00283B1B" modified="2014-10-29" version="1">MRGALKVVGSEDLGQITAADRNELEARIKELIERHQPAPLLIKLDATTLDNTYIIDKRYRHQDPEAIGEIVYFSYDERGKKISKFYGDEVKEANKEMQQNLAMHGWTMGDYYYALYAGMPANKITRNEIKENLKRLEPFEQDAIQKIRDLQQASFNRIGEKIFRVFGIRVKTTFDEKDEEEFRRNGNKRWLRSVYNTAAERKKKDEINAGRPMHLVSYLNRYCVHEMGRIIRKERDNRLSGDPVDYFRKFHPEMMTLSFADNNMLGDNEDEQDYAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRX5</accession>
    <name>A0A075MRX5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01863</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRX5"/>
    <dbReference type="KEGG" id="nev:NTE_01863"/>
    <dbReference type="HOGENOM" id="CLU_1105171_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="251" mass="27466" checksum="79FF296E7AEFBC80" modified="2014-10-29" version="1">MSIDSFVRGGSSGMLISRCLLLALVMLMISSICYMQAENHVNALASSSVVQCQYVGPAFIASDRIEPPILAPAHKGVVLGYNITALPLAQGHAGDDNNGKLSHPASAGKTDLSLKITLYDNETQKIIRFLHYNLTITNGDDQKVVLAPTLFYTTADLTLNLHAASENSTDPVVIHAPIEPTIFQAYYPPYLPEHNGTINIDNVLLEKPSTYHIHIDLLGIDSSNCFFLKPNYPPSFDIYWTLTADGKLYSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MS49</accession>
    <name>A0A075MS49_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02303</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MS49"/>
    <dbReference type="STRING" id="1459636.NTE_02303"/>
    <dbReference type="KEGG" id="nev:NTE_02303"/>
    <dbReference type="HOGENOM" id="CLU_126369_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="175" mass="19733" checksum="0F111A614E542D6F" modified="2014-10-29" version="1">MSNVGKNRNFVSQQSDQVGKLVLDDLDIGIIKEMIKDAEVKSTFLASKYDSPLSTIQRRRAKLEHTILKKKYYINISMFHWRRADLMISVDGDCGEAVSELLRNFGKNIISTSLRIGDPQANIVATVFYRDSRELLNLMDGIRSISSARCVKWSEVVRDFGPTDAGIETILSSQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MS64</accession>
    <name>A0A075MS64_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TIGR00266 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01896</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700625.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MS64"/>
    <dbReference type="STRING" id="1459636.NTE_01896"/>
    <dbReference type="GeneID" id="41597646"/>
    <dbReference type="KEGG" id="nev:NTE_01896"/>
    <dbReference type="eggNOG" id="arCOG01907">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040551_4_1_2"/>
    <dbReference type="OrthoDB" id="7592at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.160.10">
        <property type="entry name" value="Mitochondrial biogenesis AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002838">
        <property type="entry name" value="AIM24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036983">
        <property type="entry name" value="AIM24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016031">
        <property type="entry name" value="Trp_RNA-bd_attenuator-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00266">
        <property type="entry name" value="TIGR00266 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43657:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 24, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43657">
        <property type="entry name" value="TRYPTOPHAN RNA-BINDING ATTENUATOR PROTEIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01987">
        <property type="entry name" value="AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51219">
        <property type="entry name" value="TRAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="240" mass="25459" checksum="6A3D33D58E1779E7" modified="2014-10-29" version="1">MQFGIVKAPMALLEVQMAAGEKITAESGAMVYMKGDIEIKTRTREGGFLKKLKVTALGGESFFVNDFVAKSDGCSIGLTGPPIGDIVQLLVKPGSGFIVQSGSYVASTAGVLLDTQWQGFTKGLFGSEFFMLKATGEGYLFANAYGGIIQKDLLPGERMTVDNYHLVALGEQVHYNVIQVGGMKTTILGGEGLATECTGPGPVLFQTKNLRELIDILGINQRAETTSNNTGVSFGGFRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSC4</accession>
    <name>A0A075MSC4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-type multidrug transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NTE_02001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700707.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSC4"/>
    <dbReference type="STRING" id="1459636.NTE_02001"/>
    <dbReference type="GeneID" id="41597748"/>
    <dbReference type="KEGG" id="nev:NTE_02001"/>
    <dbReference type="eggNOG" id="arCOG00194">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_2"/>
    <dbReference type="OrthoDB" id="87732at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050763">
        <property type="entry name" value="ABC_transporter_ATP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42711">
        <property type="entry name" value="ABC TRANSPORTER ATP-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42711:SF5">
        <property type="entry name" value="ABC TRANSPORTER ATP-BINDING PROTEIN NATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF84058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="305" mass="33874" checksum="4B7A928FB99D236F" modified="2014-10-29" version="1">MLAIEAECVTKMYKGSSRPALSEVSLKVESGRVFTLLGRNGAGKTTFVRMCATQLMPTSGSIKVLGYDVVKQAKEVRNLISIVPQEGRPLRALTPWDHVYNWLQIRGEGKASARDKTEEFLRKLELWDARDRPAMNLSGGMKQKILVAMAMAVDTQLLFLDEPTIGLDPVSRRQVWSAIKDWKAKGRSILLTTHYMDEAEMLSDYIVIVDNGSIIAQGTIQELRRVIPHNTRVDIAKDGLDSNALKSYGSVVDTGAGMLRVFAFESAVRELSELAIRRNLPFTVSPVTLDDVFVFLVGKEAEEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSF7</accession>
    <name>A0A075MSF7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphoribosylformylglycinamidine synthase subunit PurS</fullName>
            <shortName evidence="6">FGAM synthase</shortName>
            <ecNumber evidence="6">6.3.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Formylglycinamide ribonucleotide amidotransferase subunit III</fullName>
            <shortName evidence="6">FGAR amidotransferase III</shortName>
            <shortName evidence="6">FGAR-AT III</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Phosphoribosylformylglycinamidine synthase subunit III</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">purS</name>
        <name evidence="7" type="ORF">NTE_01997</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + L-glutamine + ATP + H2O = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + L-glutamate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17129"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PurS family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.3" evidence="6"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700704.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSF7"/>
    <dbReference type="STRING" id="1459636.NTE_01997"/>
    <dbReference type="GeneID" id="41597744"/>
    <dbReference type="KEGG" id="nev:NTE_01997"/>
    <dbReference type="eggNOG" id="arCOG04462">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_164833_2_0_2"/>
    <dbReference type="OrthoDB" id="56303at2157"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1280.10">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase subunit PurS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01926">
        <property type="entry name" value="PurS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003850">
        <property type="entry name" value="PurS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036604">
        <property type="entry name" value="PurS-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00302">
        <property type="entry name" value="phosphoribosylformylglycinamidine synthase subunit PurS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34696">
        <property type="entry name" value="PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE SUBUNIT PURS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34696:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE SUBUNIT PURS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02700">
        <property type="entry name" value="PurS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82697">
        <property type="entry name" value="PurS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF84055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="92" mass="10194" checksum="F27A22E0AA5970BC" modified="2014-10-29" version="1">MARASNGKFLVQVIIENKPYINDPEGETIHRDLVVKGGYSDVKAVRSAKMLKMTVNAGSEKEAEKTVQKLCEELRIFNPVVSNCTIKAQKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSN1</accession>
    <name>A0A075MSN1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02539</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSN1"/>
    <dbReference type="KEGG" id="nev:NTE_02539"/>
    <dbReference type="HOGENOM" id="CLU_3322771_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="38" mass="4527" checksum="8FC417DBB7956E10" modified="2014-10-29" version="1">MVEIGGFSGSFFYFYITFTYFYTGIDLFLMDYTGVLHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSN5</accession>
    <name>A0A075MSN5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">PMT family glycosyltransferase, 4-amino-4-deoxy-L-arabinose transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NTE_01731</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700496.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSN5"/>
    <dbReference type="STRING" id="1459636.NTE_01731"/>
    <dbReference type="GeneID" id="41597500"/>
    <dbReference type="KEGG" id="nev:NTE_01731"/>
    <dbReference type="eggNOG" id="arCOG00567">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_490742_0_0_2"/>
    <dbReference type="OrthoDB" id="11022at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016763">
        <property type="term" value="F:pentosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050297">
        <property type="entry name" value="LipidA_mod_glycosyltrf_83"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038731">
        <property type="entry name" value="RgtA/B/C-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33908">
        <property type="entry name" value="MANNOSYLTRANSFERASE YKCB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33908:SF11">
        <property type="entry name" value="MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13231">
        <property type="entry name" value="PMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="288"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="356"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="386"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase RgtA/B/C/D-like" evidence="9">
        <location>
            <begin position="91"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIF83792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="533" mass="59559" checksum="EB24141C4EF676F7" modified="2014-10-29" version="1">MLQIAVSRGGKEPVIIFLAVIAIGLAAAFYLYFVVDKYSLLYYWDAVSHSVAARKLVDWGENPGLGQIGTVWMPLPHFLLIPFVLVDLLFSTGFAGTALSLPCLALTSVYLYKIAKGLQIPGIAVIPAYAAFAGALLYATNPNILYLGITSMTEAPFMLFFVASAYYFQMWYQKGNKLRDLILCSVFLSFATLCRYESWFLPVFLIIVVGVFAIKKKEGKDQQSNNRKALAILASILSLSSIVFWLAWNQYHYGDPFEFSNAQYYSASWYAQNRPFRELLFLQPANVLSVYGVTALAMYGPILLGAGVAGYYVFRKARIDGKKIVLLFLALPPLFTIVSLLIGIGEMSYWFNSRFMVLLSPLIIVMTCIFLAKVGDDGRIVKRRRAITIAAIVGALFIYQLAIPAFAAVITVDDAKGGYSVKENQLAIKTGEALKSLYDGNGKIMVLTGSGLEQRIMVTSGIALRNFDEIIEPSTWKASFKEPWSYDRWLVITSHPGSDALNTTKYWLDRQDELATHYNTVYENEYYKIMALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSX8</accession>
    <name>A0A075MSX8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02231</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700890.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSX8"/>
    <dbReference type="STRING" id="1459636.NTE_02231"/>
    <dbReference type="GeneID" id="41597951"/>
    <dbReference type="KEGG" id="nev:NTE_02231"/>
    <dbReference type="eggNOG" id="arCOG08033">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011320_0_0_2"/>
    <dbReference type="OrthoDB" id="268789at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd15482">
        <property type="entry name" value="Sialidase_non-viral"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="Sialidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="1026" mass="111673" checksum="65A4D5B07E276E69" modified="2014-10-29" version="1">MGIIVFSVFASANSSLAFAVPTANPDPESLVESKVAIERSFSTPLLRFNGETAAQLMQKITWFPNGTTALSDDQGSQFTFTLDLADSSFVLLSNSTMIDQKVLGKDHQYDIVWKPLRNSDGAITKYKFDIVGTSANGHTIKLLLSPQQEITVNDDSFLSLSKNYNSNSTSLFGVGLDWSDATSAGQPIAYDSEERTINIPVGKSYFIDPTTISTITAVLSPGSSDYYEGERREVRIGNVLFMFYFDGSNIVYRSSLDFGATWSSATSSGSGVINGDVHRYTVTTENVTGTNYVTLLYFKTSGSNTNFYGKRGTVGLNTITWNNETSMFSAPNFASCGTSVCAASVGAVDTSGIMYAAFRWIPSGASSYQYQIMKSANGGLGWNTSLSQIPADVGTRIEMFLTPLASGKMLFGYMRYTTDDIKYRLWDGTGWSAENTVGNIGSTANTIKHVSADSDGVKKAYVAYLTGGNSGSIKIAKWGNDGSWLGNETADSTLSHTLPSITITNDGVIHVYSLSGNKVYDTTKILNSWQTPTNPFGTTFTSPAQLTSGSGYPMALWIEGSSSPFNLRFDRTDWDVDRDGIYNNWEVNGIDSNWDGTVDFLPSSSQAHKDIFVEIDYMQNHQPDSGAINNVTNAFANAPITNPDSTTGITLHLNLDEQVTHSDTTSWPTGFNSIKPTHFGTATERAAANHDNILNAKKKIYHYNLWVHSITLNGPSGVGELLGNDFMVSMGSYNASNPSQDLAGSREHQAGTLMHELGHNLGLHHGGGVDINCKPNYLSVMNYAFQLPTFVSDRPLDYSRSQLLTLDEINLDELDGVSASTPSGLKTVYGKPGDFPVVSDPVPTGQGIDWNRDEFLGDDGVEQSINFFDIPDCDSLDLTSLTGYNDWANVQLAFTSSGTYANGTSVKVVDNEMTREIVQKMQLMTLDTIDHLLQNANATSFRDTNDAAAEKKTLHDVLDNPVSGAKAAVRQDNYGKVVAILERIRAKLDASVGGDPHDDMIVNQKEQTRILQQLDNVITSFKKAWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MT01</accession>
    <name>A0A075MT01_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Activator of Hsp90 ATPase homologue 1/2-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_02271</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700920.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MT01"/>
    <dbReference type="STRING" id="1459636.NTE_02271"/>
    <dbReference type="GeneID" id="41597986"/>
    <dbReference type="KEGG" id="nev:NTE_02271"/>
    <dbReference type="HOGENOM" id="CLU_108923_3_0_2"/>
    <dbReference type="OrthoDB" id="7204at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd08899">
        <property type="entry name" value="SRPBCC_CalC_Aha1-like_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="ASHA1/2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Activator of Hsp90 ATPase homologue 1/2-like C-terminal" evidence="2">
        <location>
            <begin position="34"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF84325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="180" mass="20279" checksum="894B627F4EE2DDE8" modified="2014-10-29" version="1">MKNAKSNDTSNNQVGTVTIEGEYATLRYERRLAYPREVVWKAITDPKELAMWFNTKAIIDGRNGGTIDFVSAPAGFHTTGRILVWDPPRAFEHEWHIAPHPDLPNGEPEAVIRWDLARDGDYGTILTVTHSRLTRSTGLGFAPGMHAFLDRLAAHLNHEALPDWMGRYEAVKALYPSWQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MT17</accession>
    <name>A0A075MT17_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">D-isomer specific 2-hydroxyacid dehydrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_02199</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MT17"/>
    <dbReference type="STRING" id="1459636.NTE_02199"/>
    <dbReference type="KEGG" id="nev:NTE_02199"/>
    <dbReference type="eggNOG" id="arCOG01755">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019796_6_3_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42938">
        <property type="entry name" value="FORMATE DEHYDROGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42938:SF9">
        <property type="entry name" value="FORMATE DEHYDROGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="2">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF84253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="186" mass="21392" checksum="568C177078AF460B" modified="2014-10-29" version="1">MGRIGQRVCERLKAFDVKMIYYDYYHLSTVEEHVLGTRYVILDQLVEQSDIITINAPLTPQTDGLFNRDLLFRMKKGAYLVNCARGRIVDTLSLVEALEKGHLAGYAGDVWYPEPAPRDHPWRRMPNQAMVPHYSGTTLEAQRRYADGTKDCLVRFFGGRPIERDYLIVDHGKVVSPSYSYAFKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MT34</accession>
    <name>A0A075MT34_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator, XRE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_01903</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700631.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MT34"/>
    <dbReference type="STRING" id="1459636.NTE_01903"/>
    <dbReference type="GeneID" id="41597653"/>
    <dbReference type="KEGG" id="nev:NTE_01903"/>
    <dbReference type="eggNOG" id="arCOG00608">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116133_0_0_2"/>
    <dbReference type="OrthoDB" id="30763at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051257">
        <property type="entry name" value="Diverse_CBS-Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017158">
        <property type="entry name" value="Tscrpt-reg_CBS-contain_prd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43080">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN CBSX3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43080:SF4">
        <property type="entry name" value="CRO-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037253">
        <property type="entry name" value="HTH_CBS_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="3">
        <location>
            <begin position="8"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="4">
        <location>
            <begin position="70"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF83962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="184" mass="20339" checksum="A30C49C7D2E36725" modified="2014-10-29" version="1">MLPRLEYIKQARMRLGITQRKLAGLTGVSTSMINQIESGRCKPSYETARKIFEALGSLEGKTSMKAGDICSRKLISVQRDEKLHEAIDMMRRNSISQIPVLDGSKVVGILTEDGLAKIMVEKDEGELKDFKVYQVMESPPPIVDVSTPAKALVPLVRFAKCILVSEKGNVMGIVTITDTLKMVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTG6</accession>
    <name>A0A075MTG6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methylase involved in ubiquinone/menaquinone biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02863</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701396.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTG6"/>
    <dbReference type="STRING" id="1459636.NTE_02863"/>
    <dbReference type="GeneID" id="41598545"/>
    <dbReference type="KEGG" id="nev:NTE_02863"/>
    <dbReference type="eggNOG" id="arCOG03534">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037990_10_0_2"/>
    <dbReference type="OrthoDB" id="8915at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="53"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="266" mass="30009" checksum="5F752D8575E4C855" modified="2014-10-29" version="1">MGAKQIDHDDDDKSHNASIISQFTKNAAHYHQLSEHSNQHGKELMLKLSKPQPDDTVLDVACGTGIVSCEFAQFVSHVTGIDLTPAMIEQAKQAQQEKQLKNITWKIGDVSKPLPFDDSSFSMVVTRYSFHHLLEPKKVLQEMERVCASKGKILVIDVTPDPDKVDAYNRVEKLRDSSHVGALTLTELENIMREAGLTDIEIEHHDLEVELESILQASSPSQNDADKIRLLFKQDLTKDNLGMRSHLKENKIHFYFPISMIVGKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTI7</accession>
    <name>A0A075MTI7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TIGR00725 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02461</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701073.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTI7"/>
    <dbReference type="STRING" id="1459636.NTE_02461"/>
    <dbReference type="GeneID" id="41598168"/>
    <dbReference type="KEGG" id="nev:NTE_02461"/>
    <dbReference type="eggNOG" id="arCOG02431">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107614_2_0_2"/>
    <dbReference type="OrthoDB" id="9570at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005268">
        <property type="entry name" value="CHP00725"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041164">
        <property type="entry name" value="LDcluster4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052341">
        <property type="entry name" value="LOG_family_nucleotidases"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00725">
        <property type="entry name" value="TIGR00725 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43393">
        <property type="entry name" value="CYTOKININ RIBOSIDE 5'-MONOPHOSPHATE PHOSPHORIBOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43393:SF3">
        <property type="entry name" value="LYSINE DECARBOXYLASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18306">
        <property type="entry name" value="LDcluster4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102405">
        <property type="entry name" value="MCP/YpsA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="182" mass="18928" checksum="270EAA2C7235FDF6" modified="2014-10-29" version="1">MRRVQIAVIGYNKDSCTEAARKAAYKVGSEVAKAGAVLVCGGLGGVMEEACRGAKDNSGTTVGIIPENDASYANKYCDIVVCSTIGFARDFIVAGTADGIIAVGGGVGTRIELSAGYMLKKPMVAIKGSGGTADEYGGKYLDERKRVEIMMVASPKEAVRVLLEKIGKNNNAGLGHDNPPHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTK7</accession>
    <name>A0A075MTK7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00543</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699558.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTK7"/>
    <dbReference type="GeneID" id="41596413"/>
    <dbReference type="KEGG" id="nev:NTE_00543"/>
    <dbReference type="HOGENOM" id="CLU_753559_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="367" mass="39359" checksum="B19193534A51ED5B" modified="2014-10-29" version="1">MFSDGSSLRVFVAIVLASGLVTAGLVHVSFAEIQIAGGNNNNNSDNNNNNTYSNLQFGIENIEFPNGWARTVQEQNSTAGTPDEITITLKLENATGTTTQSSSPPGVANPFSLFSSFSSPTNGNISSSLDNDNNNGAAANDPFSPTITIKLQKGDALQRQLATEQNQTEGQEIDLFAQNPYCKPLNPNDDNGTGNSGNNNNNTAIINGHNFTVTEQECDMAPILKLFLGAFFAGFANLANNNTNLNNNNSSSILDNNNTANGSSGTNTTGTNQETTTANSASTTNTTTATGTDADKIANFLDTLHNITTTEKRYTYTSASSNLRVELSYSALTFVSIEDFEIKAKHYQRYLPVFENIVHSVKIQQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTK8</accession>
    <name>A0A075MTK8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Signal recognition particle 19 kDa protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_02055</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTK8"/>
    <dbReference type="STRING" id="1459636.NTE_02055"/>
    <dbReference type="KEGG" id="nev:NTE_02055"/>
    <dbReference type="eggNOG" id="arCOG01217">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_169299_1_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048500">
        <property type="term" value="C:signal recognition particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.30">
        <property type="entry name" value="Signal recognition particle, SRP19-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002778">
        <property type="entry name" value="Signal_recog_particle_SRP19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036521">
        <property type="entry name" value="SRP19-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01922">
        <property type="entry name" value="SRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69695">
        <property type="entry name" value="SRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0733">Signal recognition particle</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF84112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="111" mass="12816" checksum="1C24F134FC3683BE" modified="2014-10-29" version="1">MRDRALKDYDHVILWLDYFNKNLKRRQGRKVKRDHAVFDPTVQELVEAAKTAGYQVEDDAVNDAARFPRRSFVKSGYVMLAKKEGVKKSKVIASVAEKLLQKHARQKSGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTL5</accession>
    <name>A0A075MTL5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701034.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTL5"/>
    <dbReference type="STRING" id="1459636.NTE_02413"/>
    <dbReference type="GeneID" id="41598124"/>
    <dbReference type="KEGG" id="nev:NTE_02413"/>
    <dbReference type="eggNOG" id="arCOG00002">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1639891_0_0_2"/>
    <dbReference type="OrthoDB" id="56053at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43252">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR YQJI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43252:SF5">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR, PADR-LIKE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription regulator PadR N-terminal" evidence="1">
        <location>
            <begin position="22"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="171" mass="18954" checksum="7C323F4FAD412681" modified="2014-10-29" version="1">MISEWLARVGSSIPRGFSRHYILTLLKEKPMTGKEIIDKAIAQTEGRWKPSPGLIYPLLGRLLDDGLVSENEGGRYSITTKGLAIINDLETLNGIVHKQLDAMLRVGTIGAAVATDLVDRVITIGSAIGSHADTLSKEERTKYRQFLLSELEKLDKHESRSSDRVQKIDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTP4</accession>
    <name>A0A075MTP4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTP4"/>
    <dbReference type="KEGG" id="nev:NTE_00573"/>
    <dbReference type="HOGENOM" id="CLU_2475835_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="87" mass="9500" checksum="D9A4E3CD842858DC" modified="2014-10-29" version="1">MKITSLMYFWQAVARLKEMKDTTVYTLATIGVIAALSYAIAVVPVQAQMPGPHYRPYAPYVPPANNTVAVPPVNNTILEPPICANLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTT4</accession>
    <name>A0A075MTT4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02996</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701501.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTT4"/>
    <dbReference type="STRING" id="1459636.NTE_02996"/>
    <dbReference type="GeneID" id="41598666"/>
    <dbReference type="KEGG" id="nev:NTE_02996"/>
    <dbReference type="eggNOG" id="arCOG10518">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1438160_0_0_2"/>
    <dbReference type="OrthoDB" id="11741at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="188" mass="20019" checksum="5DDC243AAB8223B1" modified="2014-10-29" version="1">MRLRRGHILLIAGGAIVALSFIASNYYASQFLKEIQEKNMHTIAPGAKFDLQGNITSGNGAYVVAFPNYSSAGSVRATVSISDPDGEPVLEKNLNLPFFSEPFAAQKQGNYTLTISNLGNTSLDASVIFGEEQVVGEVIGMPNVVSTAISSLLLIAGIIVLAAGGAIMLIDRHRDQKMKQFGDMSDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTY0</accession>
    <name>A0A075MTY0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Coenzyme A biosynthesis bifunctional protein CoaBC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">DNA/pantothenate metabolism flavoprotein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Phosphopantothenoylcysteine synthetase/decarboxylase</fullName>
            <shortName evidence="3">PPCS-PPCDC</shortName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="3">Phosphopantothenoylcysteine decarboxylase</fullName>
                <shortName evidence="3">PPC decarboxylase</shortName>
                <shortName evidence="3">PPC-DC</shortName>
                <ecNumber evidence="3">4.1.1.36</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">CoaC</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="3">Phosphopantothenate--cysteine ligase</fullName>
                <ecNumber evidence="3">6.3.2.5</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">CoaB</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="3">Phosphopantothenoylcysteine synthetase</fullName>
                <shortName evidence="3">PPC synthetase</shortName>
                <shortName evidence="3">PPC-S</shortName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="3" type="primary">coaBC</name>
        <name evidence="6" type="ORF">NTE_02602</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(R)-4'-phosphopantothenate + L-cysteine + CTP = N-[(R)-4-phosphopantothenoyl]-L-cysteine + CMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19397"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:59458"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="6.3.2.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>N-[(R)-4-phosphopantothenoyl]-L-cysteine + H(+) = (R)-4'-phosphopantetheine + CO2</text>
            <dbReference type="Rhea" id="RHEA:16793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:59458"/>
            <dbReference type="ChEBI" id="CHEBI:61723"/>
            <dbReference type="EC" id="4.1.1.36"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="3">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; coenzyme A biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the PPC synthetase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.36" evidence="3"/>
    <dbReference type="EC" id="6.3.2.5" evidence="3"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701179.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTY0"/>
    <dbReference type="STRING" id="1459636.NTE_02602"/>
    <dbReference type="GeneID" id="41598295"/>
    <dbReference type="KEGG" id="nev:NTE_02602"/>
    <dbReference type="eggNOG" id="arCOG01704">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033319_0_3_2"/>
    <dbReference type="OrthoDB" id="10536at2157"/>
    <dbReference type="UniPathway" id="UPA00241"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071513">
        <property type="term" value="C:phosphopantothenoylcysteine decarboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004632">
        <property type="term" value="F:phosphopantothenate--cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004633">
        <property type="term" value="F:phosphopantothenoylcysteine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015941">
        <property type="term" value="P:pantothenate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10300">
        <property type="entry name" value="CoaB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="entry name" value="Flavin prenyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02225">
        <property type="entry name" value="CoaBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035929">
        <property type="entry name" value="CoaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005252">
        <property type="entry name" value="CoaBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007085">
        <property type="entry name" value="DNA/pantothenate-metab_flavo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00521">
        <property type="entry name" value="coaBC_dfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359">
        <property type="entry name" value="HOMO-OLIGOMERIC FLAVIN CONTAINING CYS DECARBOXYLASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359:SF6">
        <property type="entry name" value="PHOSPHOPANTOTHENOYLCYSTEINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04127">
        <property type="entry name" value="DFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102645">
        <property type="entry name" value="CoaB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="Homo-oligomeric flavin-containing Cys decarboxylases, HFCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="3 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 3 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="4">
        <location>
            <begin position="26"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="DNA/pantothenate metabolism flavoprotein C-terminal" evidence="5">
        <location>
            <begin position="202"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphopantothenoylcysteine decarboxylase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphopantothenate--cysteine ligase" evidence="3">
        <location>
            <begin position="207"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="363"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF84645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="431" mass="46162" checksum="2332390F1F7DE1A1" modified="2014-10-29" version="1">MKQRQRRGVHPSKDITGSDGNELAGKKIVLCVTGSVAAYRAIDLARLLMRHGADVHAVMSEATASTLLHPEMMKWATGNEVVSKLTGNLEHIALADYGMSDLVIVYPCTANTIGKMVAGIDDTPVTSVLSVALGSKIPIIVAPAMHEAMYENRFIQQNVEKLHEHEGTRFIGPKIEEGKAKAAEPEQVLASAIDALAGNGPLAGRRVLVTAGSTIEYIDPIRVITNTSSGKMGIAIAKEAERMGAEVTLVYGRGTEKEPEGNNHYHVVRVDTSAQMHDAVIGELKKEEKCDIAIMAAAVADYAPASASAKKIDTRNGRLDLSLVATKKIVDDVKKASKGTFLVAFKADYGVSDALLVDKAYKKLQKCGADLVVANDIGRDGSKAGSDRNEVFIVDARKKVVHVPLGGKSEVARKLLELVSESMSKDSKTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTY7</accession>
    <name>A0A075MTY7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phytoene dehydrogenase-like oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_02612</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701188.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTY7"/>
    <dbReference type="STRING" id="1459636.NTE_02612"/>
    <dbReference type="GeneID" id="41598306"/>
    <dbReference type="KEGG" id="nev:NTE_02612"/>
    <dbReference type="eggNOG" id="arCOG01523">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028676_0_0_2"/>
    <dbReference type="OrthoDB" id="40741at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF3">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="2">
        <location>
            <begin position="17"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF84655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="448" mass="47862" checksum="CD3611DD8A665383" modified="2014-10-29" version="1">MMEKDDSPDVIVIGGGLAGLTTAALLARAGKAVTLFEQSSREIGGRARTSIDNGYYFNQGPHALFLADVGAKVLQELGVSYTGGEPPATGLGIRDAKKYRVLTNSSSPSLTPVSDFNSEDVFAKFSDLLNKTDFTELENISVTEWIERNFHDADAIALLKALISLTTYGNDPDIQSAGSALHQVHLYNLGGVMYVDRGWQTLVDGLVAAAKNAKARIVMGKKATKVQRNSSGWLVTLSDQSQISAEILVIAAGPNEAQALFHEGEKIEALSKAVKEARPVRLACLDVALSNLPQKDALFALGIDSPLYFSVHSPYAELAPPNGALIHVAKYLGSSIKPNPKEDEKELEELLDLMQPGWRQVLVKKRPLPSMVLSNTLVTAANGGLSGRVDPKIEEGLYVVGDWVGQEGLLSNASFASARRAAQLIQNELAGGSRGTGQRPSISESVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUA1</accession>
    <name>A0A075MUA1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cysteine synthase</fullName>
            <ecNumber evidence="5">2.5.1.47</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_02238</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.47" evidence="5"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700895.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUA1"/>
    <dbReference type="STRING" id="1459636.NTE_02238"/>
    <dbReference type="GeneID" id="41597958"/>
    <dbReference type="KEGG" id="nev:NTE_02238"/>
    <dbReference type="eggNOG" id="arCOG01430">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021018_1_0_2"/>
    <dbReference type="OrthoDB" id="10138at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000003">
        <property type="entry name" value="Cystathionine beta-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="4">
        <location>
            <begin position="14"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF84292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="336" mass="36844" checksum="ADAEDD0998B518CD" modified="2014-10-29" version="1">MTTTAAVASPDVVQRIGQTPLVELKSFSTKNVKMYAKLEWHNPFGSVKDRAAYWMIKDAEKRGILKKDKSIIIEPTSGNTGIALTGIATALGYKVEIVIPEKVSEETKNILRHLGATLHETSDDLCPRVGAGTDQSIALAKAISKPRPDIYYMPNQYENDANFLAHYESTGPEIWKQTNGAITHFLTGCGTGGTITGTATYLKEKNKSVKVVAVQAQKNHLLQGLRNFEESAMPDLFKKRQSVVDEWFTATNKGSFDAARLLAEKEGLLVGPSSGSVMESMLATAQKMDSGVLVGIFADDGRKFKSLYVREGVFAEQEYDRALKNARHMSSLAYSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUD3</accession>
    <name>A0A075MUD3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02273</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700922.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUD3"/>
    <dbReference type="STRING" id="1459636.NTE_02273"/>
    <dbReference type="GeneID" id="41597988"/>
    <dbReference type="KEGG" id="nev:NTE_02273"/>
    <dbReference type="HOGENOM" id="CLU_2433973_0_0_2"/>
    <dbReference type="OrthoDB" id="8531at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="96" mass="10751" checksum="B34E8D8AC9CA7A90" modified="2014-10-29" version="1">MAGGWIKGGSSDEIDELNQAINEQSDEQRKIAAKFGKAMNDFASDRSLETCLDALNLSIQLANIRAKVSNSWEHYARLLEGEVVRLSKQVEKKQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUL4</accession>
    <name>A0A075MUL4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AAA ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_02767</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701317.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUL4"/>
    <dbReference type="STRING" id="1459636.NTE_02767"/>
    <dbReference type="GeneID" id="41598456"/>
    <dbReference type="KEGG" id="nev:NTE_02767"/>
    <dbReference type="eggNOG" id="arCOG00470">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027255_1_1_2"/>
    <dbReference type="OrthoDB" id="8658at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389:SF6">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="46"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF84808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="428" mass="46609" checksum="507BAF3AA36AD459" modified="2014-10-29" version="1">MPQQPSSSPPSLMWSEVHRPQRVEQMVGNEDARITVVKWLSGWVSGTKPLLLVGPPGVGKTTIVHALARQFDYDLVEMNASDARNRDSIETRIKPVFANTGLFGRKILLFLDEVDGISGREDSGGLDALVDLIKEPTVPVIMAANEKSAKIKELAKGCKVVEFAPVPPRLLLMFLDHVLAKEKVKLGPGDKVSIVLNSGGDIRSLLNSAQSRAAGYATVSNSDVTEIDIADAINSYFAAKDRAAAMQVFARADASFPDPRYEGMSPEARRKDMVAALFSSIVSSHAVDKESLAELLDVLSKADVVVGRVSRNRQWSLLRYVRDMLSAGLYAKSRGKDIKYSQYAMPWPVMGPIFARSQTTRKIASAVGPAMNVSRSTASSTVLPYLVRAIIDEKVDTSEFAITNFGDESIGESLGKEVERAKGARKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUU9</accession>
    <name>A0A075MUU9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NTE_01000</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699912.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUU9"/>
    <dbReference type="STRING" id="1459636.NTE_01000"/>
    <dbReference type="GeneID" id="41596827"/>
    <dbReference type="KEGG" id="nev:NTE_01000"/>
    <dbReference type="eggNOG" id="arCOG02643">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_15_12_2"/>
    <dbReference type="OrthoDB" id="135877at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000141">
        <property type="entry name" value="TetR family transcriptional regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.10">
        <property type="entry name" value="Tetracycline Repressor, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039538">
        <property type="entry name" value="BetI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050109">
        <property type="entry name" value="HTH-type_TetR-like_transc_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30055:SF226">
        <property type="entry name" value="HTH-TYPE TRANSCRIPTIONAL REGULATOR PKSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30055">
        <property type="entry name" value="HTH-TYPE TRANSCRIPTIONAL REGULATOR RUTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13977">
        <property type="entry name" value="TetR_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="Tetracyclin repressor-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="6">
        <location>
            <begin position="11"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="5">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF83074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="201" mass="23151" checksum="6B6AE1513CEAA6DC" modified="2014-10-29" version="1">MRTRATSQYRAELRERIIQSAVENFAKKGFDKTRMEDIAASCGLAKGTLYLYFKSKEDLFFALCEYNLEQLRNQLSRLFSKKENIMSDAERFYDEYRRASLGADTIWFEMIALSTRNPKLRKILAENQNKVYQAVKEFLKAQIERGFFREDIDVDAIAAGLIALYNGLATNKLLLQTSNSESQRVWTETIRAIIGAASSKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUY3</accession>
    <name>A0A075MUY3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Zn-ribbon RNA-binding protein with a function in translation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699934.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUY3"/>
    <dbReference type="STRING" id="1459636.NTE_01030"/>
    <dbReference type="GeneID" id="41596853"/>
    <dbReference type="KEGG" id="nev:NTE_01030"/>
    <dbReference type="eggNOG" id="arCOG01989">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_196471_1_0_2"/>
    <dbReference type="OrthoDB" id="35104at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044720">
        <property type="entry name" value="HVO_2753-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011668">
        <property type="entry name" value="HVO_2753-like_ZBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40733:SF1">
        <property type="entry name" value="SMALL ZINC FINGER PROTEIN HVO-2753-LIKE ZINC-BINDING POCKET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40733">
        <property type="entry name" value="ZINC-RIBBON RNA-BINDING PROTEIN INVOLVED IN TRANSLATION-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07754">
        <property type="entry name" value="HVO_2753_ZBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small zinc finger protein HVO-2753-like zinc-binding pocket" evidence="1">
        <location>
            <begin position="11"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="60" mass="6649" checksum="AB6EC7DCE1FB172E" modified="2014-10-29" version="1">MYSGSYDMPKCNACGRDVHPGEISENFSCPKCKSARIWRCEGCKGKSKEYKCPACGHKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MV16</accession>
    <name>A0A075MV16_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hydrogenase 4 membrane component (E)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NTE_02452</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MV16"/>
    <dbReference type="STRING" id="1459636.NTE_02452"/>
    <dbReference type="KEGG" id="nev:NTE_02452"/>
    <dbReference type="eggNOG" id="arCOG03626">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088957_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038730">
        <property type="entry name" value="HyfE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039428">
        <property type="entry name" value="NUOK/Mnh_C1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38601">
        <property type="entry name" value="HYDROGENASE-4 COMPONENT E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38601:SF1">
        <property type="entry name" value="HYDROGENASE-4 COMPONENT E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00420">
        <property type="entry name" value="Oxidored_q2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF84502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="225" mass="24858" checksum="7F74E275E43FC704" modified="2014-10-29" version="1">MVVEIPPIDILTISSAGLLIATFGVVVRRGFADWLSAYRYQTVVLAAVTAVIAYFTGVWEIYVAAALTLVIKAIIIPKVLLRVTKKIKDEFKIETNPYVSLRLSVLISALLVALSYALTQQMFPASSLDRVTMMYLPVSISLFFIGLFVMVSRRMALNQVVGLLIIENGLFLFTTALTHGVSLIIEIGIFVDILIGIIISAILIFRISRTFDTLDIGSLEKLRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MV24</accession>
    <name>A0A075MV24_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Small-conductance mechanosensitive channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NTE_03478</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701898.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MV24"/>
    <dbReference type="GeneID" id="41599108"/>
    <dbReference type="KEGG" id="nev:NTE_03478"/>
    <dbReference type="eggNOG" id="arCOG01568">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037945_1_0_2"/>
    <dbReference type="OrthoDB" id="31543at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049278">
        <property type="entry name" value="MS_channel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045275">
        <property type="entry name" value="MscS_archaea/bacteria_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_beta-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011066">
        <property type="entry name" value="MscS_channel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011014">
        <property type="entry name" value="MscS_channel_TM-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30221">
        <property type="entry name" value="SMALL-CONDUCTANCE MECHANOSENSITIVE CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30221:SF20">
        <property type="entry name" value="SMALL-CONDUCTANCE MECHANOSENSITIVE CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21082">
        <property type="entry name" value="MS_channel_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82689">
        <property type="entry name" value="Mechanosensitive channel protein MscS (YggB), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82861">
        <property type="entry name" value="Mechanosensitive channel protein MscS (YggB), transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Mechanosensitive ion channel MscS" evidence="8">
        <location>
            <begin position="110"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Mechanosensitive ion channel MscS C-terminal" evidence="9">
        <location>
            <begin position="186"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIF85506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="317" mass="34855" checksum="EF52FC71CAA59ACF" modified="2014-10-29" version="1">MTIVSTYQLAGIPNTINVFGAEVEVFRVILTIIVIVAGVGLAYFAKAVTSRYIGTKLPPGTRKNMGRMVYYGIIAIALLSALGISHLDLSGIFLAGGIAGIVIGFATQSLFSNLISGIFLYIDKPMKVGDPVLVTGKLPDIAAVVIEVTALSTRFRMFDGTYVRLPNTEVFSSEIRNFSGAAARRVEIQIRVGLHEDKAKVLSIIRNILADNPLVLVEPEPDVYVDSVGDSGVNINIWAWAPFTEWFPVRKQLVEQVMLELEKNHVEVPLPQRVVHLDIKSNNSDRGFLSPFRGREIREGEGIDDQRDRNVDFSGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MV54</accession>
    <name>A0A075MV54_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein with SCP/PR1 domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_03101</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385607.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MV54"/>
    <dbReference type="STRING" id="1459636.NTE_03101"/>
    <dbReference type="GeneID" id="41598762"/>
    <dbReference type="KEGG" id="nev:NTE_03101"/>
    <dbReference type="eggNOG" id="arCOG03962">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061942_0_0_2"/>
    <dbReference type="OrthoDB" id="43989at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd05379">
        <property type="entry name" value="CAP_bacterial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31157">
        <property type="entry name" value="SCP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31157:SF1">
        <property type="entry name" value="SCP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="103"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF85135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="378" mass="41150" checksum="921DD209D0583254" modified="2014-10-29" version="1">MCGARYGANLPACPNCGAPNAFYGEKKRGGGNKAGIIAAIVIAAIAVIFIAPQFIEDLAGGGNNNNSAGSDDDNPVSRAIKILQPQATKPEKVPQEELVAHVLAAINSDRKKFGLEPVKLDNSNQAAQLHAEDVFRTKQISHWTSSGEKPYMTYTRLGGEGSVHQNVAIAGFGPDEYDRCVSTIILCERIDPISTIDELEKEMMYNDKECCDNGHRDNILDRDHTHVSIGIVYDEYYLALVQNFEADYGLFTSVEGTKVSIAGPMPAGAKFDNVVVYYDKLPSKEAYDANKEKLSYDAGTLAATVFEPLPRGLKYQQPGDYVVIEAGRWRNGNGNLDVSFDLAPAMKEDGVYTVYAMLEDADGEQFSATSHSIFVKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVG1</accession>
    <name>A0A075MVG1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sugar kinase, ribokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_03124</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701603.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVG1"/>
    <dbReference type="STRING" id="1459636.NTE_03124"/>
    <dbReference type="GeneID" id="41598784"/>
    <dbReference type="KEGG" id="nev:NTE_03124"/>
    <dbReference type="eggNOG" id="arCOG00014">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_805653_0_0_2"/>
    <dbReference type="OrthoDB" id="26949at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584:SF157">
        <property type="entry name" value="SULFOFRUCTOSE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="3">
        <location>
            <begin position="55"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF85158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="344" mass="37046" checksum="F8E84AFF1D2DCEF1" modified="2014-10-29" version="1">MIIDKLKQLHILGSIVVMPDFFVDRIIRLDAREKLASALEEKAKNGGGSVRGVPTTDIRGGNAVNVAYALAKMGAKVTLFTVADEMGAAMIRQSFSQFGDRVTLKIAQGRHGCTTAFEFPHDDSRVNVMVSDIGDNASFGPDKVSSKEDQAALKNADAVMVVNWASNQKGTELAEHVFKGSPSALHFIDPADIATRKQEFRDALFKLGSVTDYLSINENECDHLASALGLDAPLGASYRPDDVKKAAAKIAESIGITTDLHTRIGSAWSNGKEVEFVHAIKVEPKILTGAGDVWDAADILGYIAGLDSRERLLFANAASSLYVRQPSGEPPAMSSVFELIERVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVT3</accession>
    <name>A0A075MVT3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NAD kinase</fullName>
            <ecNumber evidence="8">2.7.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">ATP-dependent NAD kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">nadK</name>
        <name evidence="9" type="ORF">NTE_01351</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>NAD(+) + ATP = ADP + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18629"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the NAD kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.23" evidence="8"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700193.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVT3"/>
    <dbReference type="STRING" id="1459636.NTE_01351"/>
    <dbReference type="GeneID" id="41597149"/>
    <dbReference type="KEGG" id="nev:NTE_01351"/>
    <dbReference type="eggNOG" id="arCOG01348">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008831_0_2_2"/>
    <dbReference type="OrthoDB" id="77798at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275:SF43">
        <property type="entry name" value="BIFUNCTIONAL NADP PHOSPHATASE_NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20143">
        <property type="entry name" value="NAD_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 8" id="KW-0520">NAD</keyword>
    <keyword evidence="6 8" id="KW-0521">NADP</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8 9" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="68"/>
            <end position="69"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="138"/>
            <end position="139"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="178"/>
            <end position="183"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF83419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="270" mass="29194" checksum="60AAE7C38F76E1CE" modified="2014-10-29" version="1">MEKVRAVAIITKRKNAEAKAAAAKIAKMLDSKGILAYAISPLRINGIDTIEPDDVKGKADLVFAIGGDGTTLKAFRTIPGDLPLLSINVGGHRGILSEVDTDNMQSAINDILDGKGFYDSRIRIQAFLGKTAFSPALNEILITRADLSRTPTISIKLMGDEKSHRMDGIVISTPTGSTGHNLSIGGPVLHEGMSCLILSPIAPVNKMPQLVIPIEEIVVKSSHKSHLVIDGQENHIIKAGQEVRIARYPHDVRFLRLNKKGMRQLAKLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVU6</accession>
    <name>A0A075MVU6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CRISPR-associated endonuclease Cas1</fullName>
            <ecNumber evidence="9">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">cas1</name>
        <name evidence="10" type="ORF">NTE_01361</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer, forms a heterotetramer with a Cas2 homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the CRISPR-associated endonuclease Cas1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="9"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700202.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVU6"/>
    <dbReference type="STRING" id="1459636.NTE_01361"/>
    <dbReference type="GeneID" id="41597159"/>
    <dbReference type="KEGG" id="nev:NTE_01361"/>
    <dbReference type="eggNOG" id="arCOG01452">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_822842_0_0_2"/>
    <dbReference type="OrthoDB" id="2216at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09634">
        <property type="entry name" value="Cas1_I-II-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.920">
        <property type="entry name" value="CRISPR-associated endonuclease Cas1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.20">
        <property type="entry name" value="CRISPR-associated endonuclease Cas1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01470">
        <property type="entry name" value="Cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050646">
        <property type="entry name" value="Cas1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002729">
        <property type="entry name" value="CRISPR-assoc_Cas1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042206">
        <property type="entry name" value="CRISPR-assoc_Cas1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042211">
        <property type="entry name" value="CRISPR-assoc_Cas1_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00287">
        <property type="entry name" value="cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34353">
        <property type="entry name" value="CRISPR-ASSOCIATED ENDONUCLEASE CAS1 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34353:SF2">
        <property type="entry name" value="CRISPR-ASSOCIATED ENDONUCLEASE CAS1 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01867">
        <property type="entry name" value="Cas_Cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="7 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 9 10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 9" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIF83429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="356" mass="41040" checksum="817A2A2D1983AA47" modified="2014-10-29" version="1">MTLKGRKNHYNIKMLKGYGASISLKDKKVCLKGGRDAFTGKQDIEEWFVSQIPYEKIVLAGRGYVSTDAIQLLTQHNVNVILLDSYGNLITNMTRVMVSETATRYRMGQYDTFRSPGKVLYLQKKNLTAKLQSQIDFLQSLQKSELTDCINGLKKYKSRIEKQRDKRDLLRIEAGAGQLYFRYYTGLFDSKFGFDSRNGGGIKTGNRYASDVINALLNYGYSVLAAEIAKFVHGCGLDPYYGFFHKADTSFQALIYDLIEPFRWLVEYAVYKLAVEAPQHGRAIRKDEYAWTRESRIILDDALIRRFLELLERKLQSERPYRFRHGLKRRDGLSLCQEITITKINVQQLADYCVAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVX6</accession>
    <name>A0A075MVX6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NTE_02735</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701292.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVX6"/>
    <dbReference type="STRING" id="1459636.NTE_02735"/>
    <dbReference type="GeneID" id="41598425"/>
    <dbReference type="KEGG" id="nev:NTE_02735"/>
    <dbReference type="eggNOG" id="arCOG00439">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000995_6_0_2"/>
    <dbReference type="OrthoDB" id="6747at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17706">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000826">
        <property type="entry name" value="Replicative DNA helicase Mcm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF66">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="10">
        <location>
            <begin position="296"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIF84777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="691" mass="76878" checksum="5AF8289DC6D12149" modified="2014-10-29" version="1">MAEQQQATSAALADNLKEFLQAFKDREGNYRYFDRINNMMASGAQSLVVDYIDFDSYNPDLAKQLTHKPDEMLGAFNEAALAILREIHHDYEQEIHDRIKVRIGNYTVQKGLRDINADLIDKLVSVSGMVVRSSEVKPLAKKVAYKCTNCNAVTEATLKGLVLKKPSKCIACGEKELDMDPENSIFIDFQMVRLQELPEDLPAGQLPHYVEVTVMGDLVDQCRPGDRIMLTGIIRIEQEQMAPQAKTSLFRLRMEGNNIEYLGGRAGSKDTRTVERIAISTEDERQIQTIGSKPDAYEKLVASFAPHIYGQEVIKESILLLIVGSVTKKLEDGSTRRGDINVLLVGDPGTAKSEMLKFAAKIAPRGLYTSGRGSTAAGLTAAVIRDKSGIMMLEAGAVVLGDQGLVCIDEFDKIKPEDRSALHEVMEQQTCSVAKGGIVATLNARTSILSAANPMYGKYDPYKNITENVNLPVPLLTRFDLIFIVRDIPEKDKDNLIASHILEIHKDVTHAAKPAIDIDLFSKYLTYAKRIEPGLTSEAIDIIRSYYMDMRKAESEGMITVTPRQLEGLVRLATARARLLLKDRVDADDAKRAIYLVDQMLKTAGVDVNTGKMDVGVLYGKPQSEVSKQKLFMEVFNGLSGPDNNEVEDKNLVAELVKTGRFTDEEARSQISKFNREGRIYERRPGFWAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MW01</accession>
    <name>A0A075MW01_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, ArsR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03294</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
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    <dbReference type="STRING" id="1459636.NTE_03294"/>
    <dbReference type="GeneID" id="41598948"/>
    <dbReference type="KEGG" id="nev:NTE_03294"/>
    <dbReference type="eggNOG" id="arCOG00731">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_153620_0_0_2"/>
    <dbReference type="OrthoDB" id="35765at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38600">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38600:SF1">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="18"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="107" mass="12158" checksum="9D19207E7BE2BEAA" modified="2014-10-29" version="1">MTDPDAKRLLWFLFAGSRGGENRIKIIGLLKERPYNTNQLAEAMGLDYKAIQHHISVLEKNNMVTRAGEKYGVLYFVSPYLEHNIQAFDEVKAAIDKKMMGARSGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWC3</accession>
    <name>A0A075MWC3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03405</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385669.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWC3"/>
    <dbReference type="STRING" id="1459636.NTE_03405"/>
    <dbReference type="GeneID" id="43502682"/>
    <dbReference type="KEGG" id="nev:NTE_03405"/>
    <dbReference type="HOGENOM" id="CLU_3147800_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="48" mass="5375" checksum="C123064061285B25" modified="2014-10-29" version="1">MARKIVEDARAKAADVKARQRGKQTPAALEERIAALEDTIEMLLHMVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWM1</accession>
    <name>A0A075MWM1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NTE_03495</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWM1"/>
    <dbReference type="GeneID" id="41599120"/>
    <dbReference type="KEGG" id="nev:NTE_03495"/>
    <dbReference type="eggNOG" id="arCOG05380">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053359_6_1_2"/>
    <dbReference type="OrthoDB" id="11908at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052053">
        <property type="entry name" value="IM_YidH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34187:SF2">
        <property type="entry name" value="DUF202 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34187">
        <property type="entry name" value="FGR18P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
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    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="7">
        <location>
            <begin position="14"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF85523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="141" mass="15514" checksum="AD1F9ED7677AF164" modified="2014-10-29" version="1">MPEDGRRPIDLTQQYLANERTFLSWLRTSIALIGLGFVVARFGLFLREFQLVIQREAAATASTTTTNIVLPEHSFSSILGVMMIALGVGLIFYALKSYRDGNRQIESGVYVPKKSVVYTGAVLLAIFGGVTIVYLLIVSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MXF4</accession>
    <name>A0A075MXF4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03268</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701727.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MXF4"/>
    <dbReference type="GeneID" id="41598923"/>
    <dbReference type="KEGG" id="nev:NTE_03268"/>
    <dbReference type="HOGENOM" id="CLU_2476125_0_0_2"/>
    <dbReference type="OrthoDB" id="375816at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="93" mass="10764" checksum="C05C0122766C311E" modified="2014-10-29" version="1">MSRIYEIHRYRGDEFQYVVARTNKHSEDYVKADVEKMNALLSPEMRAEGIRYVFALGTVDGMNKKTGERAKKKEKQEKQQQQDGAQVQLSPAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MXI0</accession>
    <name>A0A075MXI0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MXI0"/>
    <dbReference type="STRING" id="1459636.NTE_03293"/>
    <dbReference type="KEGG" id="nev:NTE_03293"/>
    <dbReference type="eggNOG" id="arCOG10520">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_157001_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058349">
        <property type="entry name" value="DUF8036"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26119">
        <property type="entry name" value="DUF8036"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="106" mass="11817" checksum="4C84AC036612E6F0" modified="2014-10-29" version="1">MNQLRFNVRYMVMLMDVSAAVSLANIGMLAVLLAMYGRIYRNTKAVFTLGLMFFASMLVLHNAIAVYGYFAMAPLYAEALLPYFVGVHITELAGIAMLLKVTVRPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MXJ5</accession>
    <name>A0A075MXJ5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endonuclease V</fullName>
            <ecNumber evidence="7">3.1.21.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Deoxyinosine 3'endonuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Deoxyribonuclease V</fullName>
            <shortName evidence="7">DNase V</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nfi</name>
        <name evidence="8" type="ORF">NTE_03308</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Endonucleolytic cleavage at apurinic or apyrimidinic sites to products with a 5'-phosphate.</text>
            <dbReference type="EC" id="3.1.21.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the endonuclease V family.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.7" evidence="7"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701760.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MXJ5"/>
    <dbReference type="STRING" id="1459636.NTE_03308"/>
    <dbReference type="GeneID" id="41598960"/>
    <dbReference type="KEGG" id="nev:NTE_03308"/>
    <dbReference type="eggNOG" id="arCOG00929">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047631_1_1_2"/>
    <dbReference type="OrthoDB" id="7885at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043737">
        <property type="term" value="F:deoxyribonuclease V activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016891">
        <property type="term" value="F:RNA endonuclease activity producing 5'-phosphomonoesters, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06559">
        <property type="entry name" value="Endonuclease_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2170.10">
        <property type="entry name" value="archaeoglobus fulgidus dsm 4304 superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00801">
        <property type="entry name" value="Endonuclease_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007581">
        <property type="entry name" value="Endonuclease-V"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28511">
        <property type="entry name" value="ENDONUCLEASE V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28511:SF1">
        <property type="entry name" value="ENDONUCLEASE V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04493">
        <property type="entry name" value="Endonuclease_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 7 8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with target DNA" evidence="7">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF85337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="209" mass="23264" checksum="6717793067F19931" modified="2014-10-29" version="1">MTGYRLPTTPAGAIRQQKEIARKVIATDDHGEIRFVCGVDVSYRKGMAHCSAVVMDIADLNIVVEQARTKSEIKHPYIPGLFMLREAGPILRTLKRLKHYDLVMVDGHGLLHPRRCGLACYVGVVKDKPAIGAAKSLLCGSVRDDNYIELGGKTLGYMITAEGRRKKNLYVSIGHRMSLESAVSLVKSMTKKEEWLPEPLRLADTYSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MXX2</accession>
    <name>A0A075MXX2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_03449</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MXX2"/>
    <dbReference type="KEGG" id="nev:NTE_03449"/>
    <dbReference type="eggNOG" id="arCOG01057">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111585_5_3_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33204">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR, MARR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33204:SF18">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="4">
        <location>
            <begin position="26"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF85477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="141" mass="16421" checksum="CD903BCD850B6CF4" modified="2014-10-29" version="1">MQSTVSSEALKFDLELVKLYDGTKQCPINFTLKLIGNKFTLLILRNMIYFKQNRFNQFLNSIEDINTKALTNRLKEMEHEGLIERRIFNEHPVKIEYYPTKQGLALKPLLDLMASYSLTCFSKEVKDGKKRSLSQIIKNGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MXY1</accession>
    <name>A0A075MXY1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative esterase of the alpha-beta hydrolase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_03464</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MXY1"/>
    <dbReference type="STRING" id="1459636.NTE_03464"/>
    <dbReference type="KEGG" id="nev:NTE_03464"/>
    <dbReference type="eggNOG" id="arCOG09020">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042894_1_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF57">
        <property type="entry name" value="BLR7027 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="4">
        <location>
            <begin position="19"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF85492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="411" mass="46806" checksum="70971D23BD773CA6" modified="2014-10-29" version="1">MSSKGSDRAVSKKKLEKVLILQGGGSLGAFGCGVFKALAKSKEHKQLDIVAGTSIGGVNASIIAGSKEDHPEKALEQFWLELAEENNVTCLNSDHFNSESFLSSGWLTEPVMDPYYVALSSLLAIMTDDPRPKSLLSFIRSAVFGNNRMFSPRWSPDYIFKDPQFFTPKKWTYLYDLLPLEKTLAGYIDYNKLRPTGNPNSRLIMTATNVLTAEPITFDSSKQQITSKHILATSAYPLYYFPWMEVEKGLYCWDGGLLSNTPLREVIDASPIVDKEIFLVENYPKHIASLPQNLPEAFHRARDIIFSDKTLHNVKMSKVITQYLRFIDELYQIIEGHVDKSKMDKETLATIKRKYKRIKQERGAEIKRVYYISRKEKYPHVYENADFTMETIRTSIQEGELAAKEALQKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MXY7</accession>
    <name>A0A075MXY7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome C and Quinol oxidase polypeptide I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84149.1"/>
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        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
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    <dbReference type="AlphaFoldDB" id="A0A075MXY7"/>
    <dbReference type="GeneID" id="41597826"/>
    <dbReference type="KEGG" id="nev:NTE_02093"/>
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        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_670177_0_0_2"/>
    <dbReference type="OrthoDB" id="11622at2157"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.210.10">
        <property type="entry name" value="Cytochrome c oxidase-like, subunit I domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cyt_c_oxase-like_su1_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81442">
        <property type="entry name" value="Cytochrome c oxidase subunit I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="264"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="312"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="427" mass="45560" checksum="84B392BDACC8945C" modified="2014-10-29" version="1">MAGLELGANNNSTVSRPFVVSAVVLAFAGSLVGSVWTMSLFGMQAESGTYYHQVFPLHRALQIDGFLTVLIMGIGYMIVPRFRNSTLPSTKLAYVSLALALASIALSTASMASPEKGGMQQLLSSAARLAGIAVFAGMMFWMLRIRPRLLGLADYFIGLSVAMLVALGVIRLLGIGPASALSEVEVLLLFPLLMIFGVEYKTMPSFLGFIRPRKSAATASLALAIVSVTLGVSSALLDSILLSIAFNVTLLGCATAFAHSLYLFGGFDNSQILKLISGEKKARYLYTMAYSRLSFLFLYAGIAFAMLFSALSSSSDLSYLSYDLAIHLTAIGFIGTTIALYLPLMLPAITGKQVYFARFNHAPVLLLVAALAVRAAGDVVLTYGLLQPPLSYLLMASGWMVVLALAAFVVMVHRSMKGTTNTGTNIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MY14</accession>
    <name>A0A075MY14_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Di-/tricarboxylate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NTE_03514</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
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            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
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            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="AIF85542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MY14"/>
    <dbReference type="STRING" id="1459636.NTE_03514"/>
    <dbReference type="GeneID" id="41599135"/>
    <dbReference type="KEGG" id="nev:NTE_03514"/>
    <dbReference type="eggNOG" id="arCOG00238">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005170_0_0_2"/>
    <dbReference type="OrthoDB" id="19068at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015141">
        <property type="term" value="F:succinate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="SLC13_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031312">
        <property type="entry name" value="Na/sul_symport_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001898">
        <property type="entry name" value="SLC13A/DASS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283:SF82">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00939">
        <property type="entry name" value="Na_sulph_symp"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NA_SULFATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="239"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="409"/>
        </location>
    </feature>
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            <end position="460"/>
        </location>
    </feature>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="512"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="333"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="355"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF85542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="538" mass="56309" checksum="D33D85AF02711941" modified="2014-10-29" version="1">MTANFAAKEGMLGKLGLVSGPLLFIILAAFFPFPDEVTFEQRVVLGATAWMVAWWISEALPIYVTALLPIVLFPLFGVTDLGDTAARYADRIIFLFLGGFIIAKAVEKTGLHTRFALNILRIFGTNPKYVVAAFVIVTGFLSAWLSNTATAMLMVPIAAAVIALIDDEKQRARFGVCLMLAVAYSASLGGMATLVGTPPNAVFASLSKSILDTDVTFSQWMVVGMPVSAVSLFVAWAYLVNLGAGTKLDAKSMPSSSIAGEKSLITKKLAELGKMSRDEKMVAAVFLATAIAWVSRGLLWKDLVPMVDDSMIAIAAAVSLFLIPAAASSNCSAASQGDRKKKEEANSNDGNMHLPPSSTSSPSAAASPNPKKHSRAIAVAVLDWESAAKIPWGVLILIGGGLALAHAFSESGLDVRIATSLGSLGGMNYIVIILVIVAVTIFSSEFISNTASAALIIPVAASLASSLSMDPILLMASVAVATSYGFVMPVGTPPNAIVFATGHITAKRMARAGLPLDVIGIVLVTVMTSLLAPLAWGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MYD8</accession>
    <name>A0A075MYD8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein uS4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rps4</name>
        <name evidence="11" type="ORF">NTE_02225</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="6">With S5 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 8">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700885.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MYD8"/>
    <dbReference type="STRING" id="1459636.NTE_02225"/>
    <dbReference type="GeneID" id="41597946"/>
    <dbReference type="KEGG" id="nev:NTE_02225"/>
    <dbReference type="eggNOG" id="arCOG04239">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089738_1_1_2"/>
    <dbReference type="OrthoDB" id="10429at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01306_A">
        <property type="entry name" value="Ribosomal_uS4_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_uS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022802">
        <property type="entry name" value="Ribosomal_uS4_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_uS4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005710">
        <property type="entry name" value="Ribosomal_uS4_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_uS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003139">
        <property type="entry name" value="PRK04051.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01018">
        <property type="entry name" value="uS4_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="30S 40S RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF5">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS4 N-terminal" evidence="10">
        <location>
            <begin position="5"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="RNA-binding S4" evidence="9">
        <location>
            <begin position="103"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIF84279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="174" mass="19507" checksum="73CA89046F96F888" modified="2014-10-29" version="1">MGDPRKQKKLFHRPRRIWTTDQLNAELYIMGSYGLRNKRELWKAQTEMARVRNQARALLALSTEARSEKEKRLLNFLSRIGLVKEGATLDDILGLKVEDLLERRLQTIVMKRMGTKSASQARQVVSHGHVSIGNRKINRPGYIVKTDEEAKILLHVELPAAQAAGEGGGAAPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MZ13</accession>
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        <submittedName>
            <fullName evidence="1">Putative HAD superfamily hydrolase</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">NTE_02444</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701061.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MZ13"/>
    <dbReference type="STRING" id="1459636.NTE_02444"/>
    <dbReference type="GeneID" id="41598152"/>
    <dbReference type="KEGG" id="nev:NTE_02444"/>
    <dbReference type="eggNOG" id="arCOG01214">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1173412_0_0_2"/>
    <dbReference type="OrthoDB" id="27667at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1070.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="282" mass="32405" checksum="A298426AD1884050" modified="2014-10-29" version="1">MTKRVCAIISDYNGTLYPASNSKSKDAIPKELEIILSEIADHIPVCILSRNDYESLGGRVPFANIVSCILGIETIVFDRTKTKKGCKVKTRHLLLERDILHRRGYALNQLARDVGIKFPGIETVRRFTYDGLLASITFDWRNHKEYRRNYWIITQYVKEKVSTMPRDCSSSPFLQTYDSYPFLDVHAAQCDKGFGFDRIIAEMDDYSKGPILYLGDSENDNPAFRKADISIGVSSSKKSPKLDCQYLIEYNHLSRFLRRLQDNDFEFHKELLTGSSFRVDSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MZ72</accession>
    <name>A0A075MZ72_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MZ72"/>
    <dbReference type="KEGG" id="nev:NTE_02500"/>
    <dbReference type="HOGENOM" id="CLU_1700201_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="154" mass="17257" checksum="C9DA5AD2CEEB4380" modified="2014-10-29" version="1">MHTENDGGSCNDLVCRYCKKGRLHLLAHDPKGGNRFACDNPDCTRYGSPVSVRIHVEHIVPCTEPIDPRTTQASLMLGLWWAFLLYMQKVATDASALSDHCTSELPRKQERSVKSIKSLVQNALEDCPYCSGALYLPEAELRTHKSLEHQMDAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N0A7</accession>
    <name>A0A075N0A7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Urease, beta subunit</fullName>
            <ecNumber evidence="3">3.5.1.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_02891</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.1.5" evidence="3"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N0A7"/>
    <dbReference type="STRING" id="1459636.NTE_02891"/>
    <dbReference type="KEGG" id="nev:NTE_02891"/>
    <dbReference type="eggNOG" id="arCOG04527">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129707_2_1_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035550">
        <property type="term" value="C:urease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009039">
        <property type="term" value="F:urease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00407">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.150.10:FF:000001">
        <property type="entry name" value="Urease subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.150.10">
        <property type="entry name" value="Urease, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01954">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002019">
        <property type="entry name" value="Urease_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036461">
        <property type="entry name" value="Urease_betasu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050069">
        <property type="entry name" value="Urease_subunit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009682">
        <property type="entry name" value="PRK13203.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00192">
        <property type="entry name" value="urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33569">
        <property type="entry name" value="UREASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33569:SF1">
        <property type="entry name" value="UREASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00699">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51278">
        <property type="entry name" value="Urease, beta-subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF84929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="153" mass="16875" checksum="E13A74A360D1F9FC" modified="2014-10-29" version="1">MVKKNGKTTKKRKAASQQQRVSKKEEVTSSPMMPGEYILAPDPVMCNTNRKTVKITVKNKGDRPCQIGSHTHFFEVNRALDFPREKAFGYRLNIPAGTSIRFEPGDSKDVELCEIGGARVCYGFNGLTMGSLNSSMVMRAAVEKAQKQGFNGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N0L2</accession>
    <name>A0A075N0L2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02984</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N0L2"/>
    <dbReference type="STRING" id="1459636.NTE_02984"/>
    <dbReference type="KEGG" id="nev:NTE_02984"/>
    <dbReference type="HOGENOM" id="CLU_2313652_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="99" mass="10965" checksum="E0FAF15A387297FA" modified="2014-10-29" version="1">MDYLFSTERSDGTTIGQELLEKTRTELAERFGGVTVLPPFSGTTIQNGTRHDGASNAGFFVVAPNTPENIKWFLDYRETMKERFGIDGIFTTISPSVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N101</accession>
    <name>A0A075N101_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701604.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N101"/>
    <dbReference type="STRING" id="1459636.NTE_03125"/>
    <dbReference type="GeneID" id="41598785"/>
    <dbReference type="KEGG" id="nev:NTE_03125"/>
    <dbReference type="eggNOG" id="arCOG08788">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2550069_0_0_2"/>
    <dbReference type="OrthoDB" id="7750at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="86" mass="9608" checksum="6E0E3E9CF366BABD" modified="2014-10-29" version="1">MIESGDAARVVDTLAKNLAGVAMNKSNFARLPDTFWGYYAKGHDGKNGRFAVIVTYSEKGDDVDDLVKMYEQWIARNKNTTTTTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N1A4</accession>
    <name>A0A075N1A4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zn-dependent alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_03215</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701679.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
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    <dbReference type="STRING" id="1459636.NTE_03215"/>
    <dbReference type="GeneID" id="41598872"/>
    <dbReference type="KEGG" id="nev:NTE_03215"/>
    <dbReference type="eggNOG" id="arCOG01458">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_3_4_2"/>
    <dbReference type="OrthoDB" id="8709at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051603">
        <property type="entry name" value="Zinc-ADH_QOR/CCCR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44154">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44154:SF1">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="11"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF85244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="346" mass="36753" checksum="5A779115D732839B" modified="2014-10-29" version="1">MMKAVPFYQHGPVDMLRYEDFPEPEPAKGQVVIDVEYCGVNHLDIWTRMGITGKKIRLPHICGCDIVGAVKKSAAGFDAGERVMVYPGASCGKCTHCKAGRENLCSQFAIIGGTSDYNGGYAAQVAVPARNVVRLGKMKIDLKTAATLAVSYLTAWNMLSANSAKKGKSLLVYGAASGVGMATIQLARAMGVSTIITTAAGPEKAKFGKKLGAHHVIDRSETKDIAGEVFARLGGKGVDIVIDHVGAATWQTSIASLMPGGRMAVCGMTSGNDATVPVRMFYSKQVAMTGALLGTKAQLVELLRLVQAKKIKPVIDSVFPLKEAGQAQDRMEKGLHAGKILLNCRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N1K2</accession>
    <name>A0A075N1K2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N1K2"/>
    <dbReference type="STRING" id="1459636.NTE_03315"/>
    <dbReference type="KEGG" id="nev:NTE_03315"/>
    <dbReference type="HOGENOM" id="CLU_2490279_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="86" mass="9227" checksum="F779A9D4FD32490C" modified="2014-10-29" version="1">MLLVASHDNIYALWLEDVNATESSYEQRILMRASMDGGKTFSSVTTLEDVITVPEFEAAAAVVAALAVGGVVAAARFTKYKRTSAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N1T1</accession>
    <name>A0A075N1T1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03386</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385667.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N1T1"/>
    <dbReference type="STRING" id="1459636.NTE_03386"/>
    <dbReference type="GeneID" id="43502681"/>
    <dbReference type="KEGG" id="nev:NTE_03386"/>
    <dbReference type="HOGENOM" id="CLU_3075140_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="52" mass="5873" checksum="765748C56C6D5615" modified="2014-10-29" version="1">MSMTSQREDTTLNVDRDILDLLGILAVQENRTKKGEIAFLVKERARKLGVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N262</accession>
    <name>A0A075N262_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03506</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N262"/>
    <dbReference type="KEGG" id="nev:NTE_03506"/>
    <dbReference type="HOGENOM" id="CLU_184936_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="94" mass="10511" checksum="B98E6B8C0028F6D0" modified="2014-10-29" version="1">MRSIRTGGYYPVGIVDIGVLPLEARTCGGRNKSRVAYILPQTHLMMTVDKKEILLAEIKACESLLLKCGYNSEIEKNAIEQELTELKMVLDLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ML44</accession>
    <name>A0A075ML44_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Precorrin-6Y C5,15-methyltransferase (Decarboxylating)</fullName>
            <ecNumber evidence="2">2.1.1.132</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00067</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.132" evidence="2"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699209.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ML44"/>
    <dbReference type="STRING" id="1459636.NTE_00067"/>
    <dbReference type="GeneID" id="41596017"/>
    <dbReference type="KEGG" id="nev:NTE_00067"/>
    <dbReference type="eggNOG" id="arCOG00650">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089162_1_0_2"/>
    <dbReference type="OrthoDB" id="42238at2157"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046025">
        <property type="term" value="F:precorrin-6Y C5,15-methyltransferase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11644">
        <property type="entry name" value="Precorrin-6Y-MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="entry name" value="Cobalt-precorrin-4 Transmethylase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012818">
        <property type="entry name" value="CbiE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051810">
        <property type="entry name" value="Precorrin_MeTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02467">
        <property type="entry name" value="CbiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47036">
        <property type="entry name" value="COBALT-FACTOR III C(17)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47036:SF1">
        <property type="entry name" value="COBALT-FACTOR III C(17)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="Tetrapyrrole methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tetrapyrrole methylase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="238" mass="26681" checksum="C4919A029031F30E" modified="2014-10-29" version="1">MPKKLFVVGVGPGSPLYVTDAAKEAVRKSKYIVGYKYTLATIEGVIDRSRQEVLEVTMKSQEDVYQGVYARMKDGEYCTVPFTGDVNFSESEVVDRLLEIFGDDNVQIIPGISSIQVAAAKSRVPTDKAFIVTFHVTGDIEQKKKDLVQAVKDGKSVILLPRPWPRDLSKHFMQSDIAKFLKASGIDTQKLKVWVFEHLTTDKETTFKGVASDLEGKEFSDLSAMVIDQVKRQTYLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MM93</accession>
    <name>A0A075MM93_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">IPT/TIG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699266.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MM93"/>
    <dbReference type="STRING" id="1459636.NTE_00148"/>
    <dbReference type="GeneID" id="41596087"/>
    <dbReference type="KEGG" id="nev:NTE_00148"/>
    <dbReference type="eggNOG" id="ENOG502N5C2">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082633_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.450.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047002">
        <property type="entry name" value="Tcp10_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69349">
        <property type="entry name" value="Phage fibre proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="293" mass="27544" checksum="60F9BF5BA46D2710" modified="2014-10-29" version="1">MSSLTGNRKLLTSCLLVAGFAIASLAMVSPFASAQNATNGTATGGNVTAPPGGNVTAPPGGNVTAPPGGNVTAPPGGNVTAPPGGNVTAPPGGNVTAPPGGNVTAPPGNITALSKNATLVLTPSSVNADEQLTVTGSGFSSNQNATLMIDDLTLDTLEPVTTDANGSFTATATPPADITSGSHDVSATDANGVKASTTLTVSATTPSGNATSTTPSGNATSTTPSGNATSTTPSGNATSTTPSGNATSTTPSGNATSTTPSGNATSTTPSGNATSTTPSGNATSTTPSGNATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMB2</accession>
    <name>A0A075MMB2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00311</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMB2"/>
    <dbReference type="STRING" id="1459636.NTE_00311"/>
    <dbReference type="KEGG" id="nev:NTE_00311"/>
    <dbReference type="HOGENOM" id="CLU_2366064_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="95" mass="10159" checksum="A68435F405425F32" modified="2014-10-29" version="1">MTSFAAVVFIVSGGGEGRRGEGALACISKKDEKEEKVGLTKGLIATTTTAGSISLDLHEGCVNSKDNYYNSMLNLYIQKYAKHSKAPIKNTAKKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MME3</accession>
    <name>A0A075MME3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00341</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MME3"/>
    <dbReference type="STRING" id="1459636.NTE_00341"/>
    <dbReference type="KEGG" id="nev:NTE_00341"/>
    <dbReference type="eggNOG" id="arCOG02125">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027402_15_2_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47515:SF2">
        <property type="entry name" value="INTEGRASE CORE DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47515">
        <property type="entry name" value="LOW CALCIUM RESPONSE LOCUS PROTEIN T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13565">
        <property type="entry name" value="HTH_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13683">
        <property type="entry name" value="rve_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="118"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="308" mass="36200" checksum="0523EB250FCC3589" modified="2014-10-29" version="1">MITMLEYSGKTVSDVCAEFGVSRETWYKWKKRYDTYGLDGLKDLSRRPHHIKYVKVTADVEKLILELRLNHRFGPRRIGFRLRKKYGVVLAAKTIYHVLKKHKLNVLSVKLKRKYKRFEKKHSNDMVQMDTKGPFYLRGSREKQYLTHCIDDCSRKVVSEWVNRRSTEESLMVLKKWIAENGKPKKVMHDGGKQFVSRGFQKFLQDNDSIKDKQIPPGYPQAQGKVEAYNKIVISEFLEVEELKGKEDGKKKYEAFVWFYNNEREHGGIGGMTPAEKFRKRLKQPGLQAKARQKVSVMSVHQFVNHVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMI4</accession>
    <name>A0A075MMI4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative flavin-nucleotide-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_00263</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699348.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMI4"/>
    <dbReference type="STRING" id="1459636.NTE_00263"/>
    <dbReference type="GeneID" id="41596174"/>
    <dbReference type="KEGG" id="nev:NTE_00263"/>
    <dbReference type="eggNOG" id="arCOG00516">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140794_0_0_2"/>
    <dbReference type="OrthoDB" id="139492at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070967">
        <property type="term" value="F:coenzyme F420 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052019">
        <property type="entry name" value="F420H2_bilvrd_red/Heme_oxyg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35176">
        <property type="entry name" value="HEME OXYGENASE HI_0854-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35176:SF6">
        <property type="entry name" value="HEME OXYGENASE HI_0854-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="PNPOx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine 5'-phosphate oxidase N-terminal" evidence="2">
        <location>
            <begin position="17"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF82345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="156" mass="17679" checksum="BF411EADC9155D25" modified="2014-10-29" version="1">MKIIHATPGMGAPMDEQELRNFLSTSKQNCRLGTVDELGDPNVHPVWFIYEPRSEKIYINTNVDSRKIANVRKRDTVYFCIDDEAMPVKGVKGKGKTKISENPKDNLPIVEKIMIKYLGSVDHPTARSILETVKSGKSILLEISPSYFSTWDFGKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMJ5</accession>
    <name>A0A075MMJ5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_00391</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMJ5"/>
    <dbReference type="STRING" id="1459636.NTE_00391"/>
    <dbReference type="KEGG" id="nev:NTE_00391"/>
    <dbReference type="HOGENOM" id="CLU_519366_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008553">
        <property type="entry name" value="DUF835"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024478">
        <property type="entry name" value="HlyB_4HB_MCP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12729">
        <property type="entry name" value="4HB_MCP_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05763">
        <property type="entry name" value="DUF835"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chemotaxis methyl-accepting receptor HlyB-like 4HB MCP" evidence="3">
        <location>
            <begin position="7"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Chemotaxis methyl-accepting receptor HlyB-like 4HB MCP" evidence="3">
        <location>
            <begin position="118"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="DUF835" evidence="2">
        <location>
            <begin position="392"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="290"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF82473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="524" mass="57659" checksum="501F1BB1B9C75AE8" modified="2014-10-29" version="1">MQTRALLVLSFVIISVIPASLLSAISFFSLSRLEQSISNIYLGTVTIISNLSDGHKDLIEMRLNVGRLISATDDQQKQGILKQIEQNEGNFLRTLIGYKEIDDFPLQIDILQRRGLSNMTSYEDSLLTQVNDDWLEYQQARNMVITLTNEGSRENATAYSNTVAADRFSKLATSYNKIVDLNNNLASIMFDESQSVAKQAYTFAVITSASSIAFAVAAAFLISKRLAPSVDELQREARKKIEMFISKGIGGKGRGNDDSSKLATTISTNNVQKEKTSESTPSALIQTGRNNSDNNNNDNLVPEELEEQVGDLLQKGPMILLHFSQYKELMERQHASEDNQQQTRIRTVADSLLDYYLTTATGDASSSPSSSSTSLRTTSSSSPSSESSARDKKTNLVLITKRTSNLYSLGRNAGATIYVLSSSSQDPITTSADGLLVISINQTSLILEAIKRTLRENPNSVIVLDNITELIHKLGFAKVFSLIQSVSDEVSPYPNSRIIVLINENAHPRNEVEAIATICNAFIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMK6</accession>
    <name>A0A075MMK6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutamate racemase</fullName>
            <ecNumber evidence="2">5.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NTE_00401</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-glutamate = D-glutamate</text>
            <dbReference type="Rhea" id="RHEA:12813"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29986"/>
            <dbReference type="EC" id="5.1.1.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.1.1.3" evidence="2"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699444.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMK6"/>
    <dbReference type="STRING" id="1459636.NTE_00401"/>
    <dbReference type="GeneID" id="41596282"/>
    <dbReference type="KEGG" id="nev:NTE_00401"/>
    <dbReference type="eggNOG" id="arCOG02005">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052344_1_0_2"/>
    <dbReference type="OrthoDB" id="6363at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008881">
        <property type="term" value="F:glutamate racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1860">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00258">
        <property type="entry name" value="Glu_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015942">
        <property type="entry name" value="Asp/Glu/hydantoin_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001920">
        <property type="entry name" value="Asp/Glu_race"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004391">
        <property type="entry name" value="Glu_race"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00067">
        <property type="entry name" value="glut_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21198">
        <property type="entry name" value="GLUTAMATE RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21198:SF3">
        <property type="entry name" value="GLUTAMATE RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01177">
        <property type="entry name" value="Asp_Glu_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53681">
        <property type="entry name" value="Aspartate/glutamate racemase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF82483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="266" mass="29926" checksum="29CBCDA117ED95F7" modified="2014-10-29" version="1">MTNNPVAVFDSGIGSLSIIRELKKAVPAEDLLYFADRAHFPYGNKSHQQLLEITVNTINYLKRYKPKLVVMASNTPSVQVLEEVKKRVGGMPIIGVRPPLKEAVRLTKKKHIGIMATAGTINSKELENQIRREVPQHILVTKFNASPIVELVENGVHLENERRTFDVVSRVLGDGVDEKIDVMTLSSTHLPFVKSYLNALLPTVRFVDPAQMVAKDVRKFLSFYRMAKKSGSGRLQILVSDGKREFEKSIRAMGVREPVEEVFLTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMM3</accession>
    <name>A0A075MMM3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UDP-N-acetyl-D-mannosaminuronate dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.336</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_00308</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.336" evidence="3"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987105.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMM3"/>
    <dbReference type="STRING" id="1459636.NTE_00308"/>
    <dbReference type="GeneID" id="41596212"/>
    <dbReference type="KEGG" id="nev:NTE_00308"/>
    <dbReference type="eggNOG" id="arCOG00252">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069297_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089714">
        <property type="term" value="F:UDP-N-acetyl-D-mannosamine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028359">
        <property type="entry name" value="UDP_ManNAc/GlcNAc_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43491">
        <property type="entry name" value="UDP-N-ACETYL-D-MANNOSAMINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43491:SF1">
        <property type="entry name" value="UDP-N-ACETYL-D-MANNOSAMINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500136">
        <property type="entry name" value="UDP_ManNAc_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDP-glucose/GDP-mannose dehydrogenase dimerisation" evidence="2">
        <location>
            <begin position="192"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF82390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="301" mass="33983" checksum="FB25C5DFC260DA82" modified="2014-10-29" version="1">MSNNGKTTRTTSAHYSTSKKQVLVIGLGQIGYSNAEYMTMKGLTVDGYDISEKAIQRAVDDQVIRKRAQSFAGYDYYIICISTHRPEDMFQPYLDGLFDIARQLLYEGKQGALVGIDSTITRGTSEKVLEMLRHKMHVVHVPHRYFGPEKHDHGVNQTRVIGGCGECCIEAAKHFYGNLLDIPLHTVESVEVAELCKIVENSYRFMEIAFAEELKMFCDRSAIDFQELREAINTKWNIKVLEPREGIGGHCLPKDSQMFLGLLKNVLDTSIIDAAKKVDEEYRRHHSVYAVSAKVKSPQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMT0</accession>
    <name>A0A075MMT0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Gp5/Type VI secretion system Vgr protein OB-fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00502</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699530.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMT0"/>
    <dbReference type="STRING" id="1459636.NTE_00502"/>
    <dbReference type="GeneID" id="41596375"/>
    <dbReference type="KEGG" id="nev:NTE_00502"/>
    <dbReference type="eggNOG" id="arCOG10240">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019505_1_0_2"/>
    <dbReference type="OrthoDB" id="147080at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.230">
        <property type="entry name" value="Gp5 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006531">
        <property type="entry name" value="Gp5/Vgr_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037026">
        <property type="entry name" value="Vgr_OB-fold_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04717">
        <property type="entry name" value="Phage_base_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69255">
        <property type="entry name" value="gp5 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gp5/Type VI secretion system Vgr protein OB-fold" evidence="1">
        <location>
            <begin position="13"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="170" mass="18712" checksum="DE912B3BBDC72BC7" modified="2014-10-29" version="1">MIEGRKRVYGKFRGKVADNADPKLKGRIRVKLTTSIYGDEMSGWAEPSLPYCAPDAGFFFVPPVDANVWVEFEEGDPDKPIWTGCFWNPDESPVNGLASAQEAHKIKMIKTESGTIKIDDREGQDIITIETASGLKIVMNSEWIELSNNAAKIKMTSSSVSVNDGALEVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMT6</accession>
    <name>A0A075MMT6_9ARCH</name>
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        <recommendedName>
            <fullName evidence="3">Polyketide cyclase / dehydrase and lipid transport</fullName>
        </recommendedName>
    </protein>
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        <name evidence="1" type="ORF">NTE_00383</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699432.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMT6"/>
    <dbReference type="GeneID" id="41596267"/>
    <dbReference type="KEGG" id="nev:NTE_00383"/>
    <dbReference type="eggNOG" id="arCOG05264">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069867_4_0_2"/>
    <dbReference type="OrthoDB" id="66844at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd07822">
        <property type="entry name" value="SRPBCC_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36166">
        <property type="entry name" value="CHROMOSOME 9, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36166:SF1">
        <property type="entry name" value="SRPBCC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="157" mass="17696" checksum="FD522900B4B5DAC4" modified="2014-10-29" version="1">MEEIHTTVVIDTPAFVVWNIIADFPKYPEWNPFILKISGELKIDSKLEMEIKLANEKIVHDEFVVLDAETEREIAWGGKNGGNLFGVEHRLAIQPLAYSRVTFLQTVRFGGDIVSLVARNLQPLLGKQLESMNVALKQRAEQSWKENPPPDKSDVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMX6</accession>
    <name>A0A075MMX6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TfoX N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00428</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699468.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMX6"/>
    <dbReference type="GeneID" id="41596307"/>
    <dbReference type="KEGG" id="nev:NTE_00428"/>
    <dbReference type="HOGENOM" id="CLU_136016_4_1_2"/>
    <dbReference type="OrthoDB" id="378351at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.30">
        <property type="entry name" value="YgaC/TfoX-N like chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007076">
        <property type="entry name" value="TfoX_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04993">
        <property type="entry name" value="TfoX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159894">
        <property type="entry name" value="YgaC/TfoX-N like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TfoX N-terminal" evidence="1">
        <location>
            <begin position="21"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="121" mass="13492" checksum="E59DA56FDA89D97B" modified="2014-10-29" version="1">MGYNENLAEKLRILLASRSKKDYSEKKMFGGLSFMIGGKMCVGILNDDLVLRVGAERNDEALALPHARPMDFTGKPMKGFVYVGPGGWQKDAILLKCVEMGIDYVSLLPAKKRKKKAQQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MN17</accession>
    <name>A0A075MN17_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Short-chain alcohol dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_00813</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MN17"/>
    <dbReference type="STRING" id="1459636.NTE_00813"/>
    <dbReference type="KEGG" id="nev:NTE_00813"/>
    <dbReference type="eggNOG" id="arCOG01259">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_9_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF82891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="286" mass="31162" checksum="7A4A6782A2EA44C9" modified="2014-10-29" version="1">MSGGEREAMQTAIVTGSSSGIGLETSLALARNGFYTYATMRNPAKGKALVDRAEKEELPLQVAELDVDKSESVKNTIDGIMEERKRIDVVVNNAGFALVGALEETSMDEIKAQFETNLFGALRVMKAVISIMRRQAGGTIVNITSMGGRVAIPLDPIYHGTKFALEGITESIRYELQPFGINVVLVEPGAVKTNFFDNLKFAHGATRQDSPYAKFMSGLQAAAAHMVQDAIPAREVAEAIVQAVKSDSPQMRYIVGKDAQAMIEAKKSMGDREFEKFMSARFAERQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MN30</accession>
    <name>A0A075MN30_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00474</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MN30"/>
    <dbReference type="KEGG" id="nev:NTE_00474"/>
    <dbReference type="HOGENOM" id="CLU_3338259_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="37" mass="3951" checksum="1E2AF0BEED7BE1FE" modified="2014-10-29" version="1">MGIFKQGSVNYGNFLLTTAARTAIVIIIIIIEVVALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MN82</accession>
    <name>A0A075MN82_9ARCH</name>
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        <submittedName>
            <fullName evidence="3">Peptidase propeptide domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_00925</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699856.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MN82"/>
    <dbReference type="STRING" id="1459636.NTE_00925"/>
    <dbReference type="GeneID" id="41596760"/>
    <dbReference type="KEGG" id="nev:NTE_00925"/>
    <dbReference type="HOGENOM" id="CLU_102442_0_0_2"/>
    <dbReference type="OrthoDB" id="378124at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025711">
        <property type="entry name" value="PepSY"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03413">
        <property type="entry name" value="PepSY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="PepSY" evidence="2">
        <location>
            <begin position="86"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="PepSY" evidence="2">
        <location>
            <begin position="169"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF83001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="239" mass="24493" checksum="2617213F0B551F1B" modified="2014-10-29" version="1">MSGLTGNEKKRLFIPALLSAIGFAVASLAAVVVTMPSASAQVPVNPTEGNATQQTSSFSLQTNGTINAKQAAKDFLNENLNATFVDASDTAENQVANGTVVSGHLDVVQSFLVYNTTVANLDNSTVYSVFIDPSNGRVLGTSEARPLSTIGQVGENLSNAGNLTATLVDAASTAEGQFANGAAIAGSFEVMQGNPVYNITVVNVNDGMLFQVVVDPRTGSILTTSEGTPMGDLGIGGVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MN93</accession>
    <name>A0A075MN93_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MN93"/>
    <dbReference type="STRING" id="1459636.NTE_00940"/>
    <dbReference type="KEGG" id="nev:NTE_00940"/>
    <dbReference type="HOGENOM" id="CLU_221465_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="29" mass="3053" checksum="E192D768C8D8BEEF" modified="2014-10-29" version="1">MVDMALAIFVASLVVSAAVLAYSLLRAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNF9</accession>
    <name>A0A075MNF9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative nucleic acid-binding protein, contains PIN domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNF9"/>
    <dbReference type="KEGG" id="nev:NTE_00260"/>
    <dbReference type="eggNOG" id="arCOG02222">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_135601_1_1_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIN" evidence="1">
        <location>
            <begin position="5"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="131" mass="14391" checksum="258B46DEDAB33E28" modified="2014-10-29" version="1">MLILYLEEKGAERVAELLTQVLEGKIKGYMSVVNLAELYYILARKSSKIAEEKERNLRSFGIRIVPVKGDPEDAAMWKEAALLKASPSLSLSLSLAYAFAAATAKVLSSTLVTGSDPEFERIKGIRTERVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNP3</accession>
    <name>A0A075MNP3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01098</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699987.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNP3"/>
    <dbReference type="STRING" id="1459636.NTE_01098"/>
    <dbReference type="GeneID" id="41596914"/>
    <dbReference type="KEGG" id="nev:NTE_01098"/>
    <dbReference type="eggNOG" id="arCOG08673">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1444623_0_0_2"/>
    <dbReference type="OrthoDB" id="8013at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="187" mass="21623" checksum="404972371B136142" modified="2014-10-29" version="1">MPKRKIKEEKPKKRLGKKEMLIIPIIMGGATLVALLLTQLYPPPPPWQVCLKNHNVETFQLFPRIEVMVDGQPMQLPDNVGHQPKDGQECLRPIHTDKVGNDVHIEYIRPVKLSMVDFMRIYSYDNRTITVVSNSTGSNVDQVLTLNDYNVQYSYFSEKNEFTKVPDIKDVPVFTKEMVVRMELTHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNQ2</accession>
    <name>A0A075MNQ2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Thermosome subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NTE_00355</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699411.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNQ2"/>
    <dbReference type="STRING" id="1459636.NTE_00355"/>
    <dbReference type="GeneID" id="41596246"/>
    <dbReference type="KEGG" id="nev:NTE_00355"/>
    <dbReference type="eggNOG" id="arCOG01257">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008891_7_3_2"/>
    <dbReference type="OrthoDB" id="9362at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03343">
        <property type="entry name" value="cpn60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012714">
        <property type="entry name" value="Thermosome_arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02339">
        <property type="entry name" value="thermosome_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="526"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="536"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF82437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="553" mass="59130" checksum="4FB11AD18A9D3F6F" modified="2014-10-29" version="1">MSATTQVPIVVLKEGTSETKGNQAQRNNITAAKTVAEIVRTSLGPRGMDKMLVDTLGDVTITNDGATILKEIDIQHPAAKMMVEISKATDNEVGDGTTSTVVLAGSLLEKAEELITKNVHPTVVVEGFKKASQKAIETLREIATKVDPNDKAFLNKIARTSMASKMVSADSEELSDMVVDAVLAVAERSGEQHKVDIDNIKVEKKAGGSVRDTKFIHGIVLDKEVVHAGMPKRIENAKIAVVNSALEIEKTEFDAKININSPDQMQRFIDEENRMLKAMVDKVVAAGANILLCQKGIDDIAQHYLAKAGILAVRRIKESDMYKLSRATGARIVNNLDELAAGDLGFAKVVEERKVETDKWVFVEGCKNPKSVSILVRGGSQRVVDEAERSVHDAIMAVKDVVEYPYVLVGGGAPEALASLKLRDWAATLSGRAQLAAEKFADGIETIPIVLAENAGMDPLDTQVQLRSKSSTGKARYGIDVTNGKVADLAAKDIYEPLAVKEQVINAATEAACMILRIDDVIAASSKSKDMPKPGGPGGGMGGGMGGMGDMDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNS8</accession>
    <name>A0A075MNS8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699433.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNS8"/>
    <dbReference type="GeneID" id="41596268"/>
    <dbReference type="KEGG" id="nev:NTE_00385"/>
    <dbReference type="HOGENOM" id="CLU_2874900_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="63" mass="7519" checksum="CA47A44F6D956443" modified="2014-10-29" version="1">MEHELLQRYGHPFFTRDQIDALMDYFGVEDHDLLEPFLNREITEEADYAFGLVGSKTREMRQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNU3</accession>
    <name>A0A075MNU3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exo-alpha-sialidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699763.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNU3"/>
    <dbReference type="GeneID" id="41596653"/>
    <dbReference type="KEGG" id="nev:NTE_00805"/>
    <dbReference type="eggNOG" id="arCOG08643">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_517425_0_0_2"/>
    <dbReference type="OrthoDB" id="2272at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd15482">
        <property type="entry name" value="Sialidase_non-viral"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="Sialidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="494"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="526" mass="55805" checksum="C3AF8CDC459C6AB8" modified="2014-10-29" version="1">MPTISERILLCGLLLLLVMFLVPKHYASAQYGCPPISGGYEPKVIARGENSGDVFVFWNYFYDCGQRVLFFKKSADNGNTFGNSIVIADSNTAGSAPAVSTSSDGNNLYVAWFKYTQPSPTLFFKKSTDNGATFGEAVKIDTNGTVQNGIFGVLASPANNNNIGIIWSGILANNGTDAVFLSKSLNGGESFSQPVLLGKGTAGYLTTPHMVQTGTQAYVLWSSAGDLGRADFVTKINMDKSDGGPFSVRPAVSLGNIGARAIAVSDDNVYVAGTTSSSADDSSEGIASGVSILLAKSNDGGLDFDKPAVLANYNSPDSNHVNSLTLDASENFVYLTWYNFHSPQIGAEIDARASADYGNTFGSIQKINSGTRVSEPIVTAASGDRFYVSWQDAGFRNNTSYQKLFFVPSSDGGDTFGKPVDLTGNTGISNPGQAMAADDDKNHVYIAWLDYAFKDGNHIMFTKNIDGGYNFGNATDLDEDSQTITEASSPSPEFGIPFALMAIMMAGAVGIILVATRTGWFGLKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNU7</accession>
    <name>A0A075MNU7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNU7"/>
    <dbReference type="KEGG" id="nev:NTE_00405"/>
    <dbReference type="HOGENOM" id="CLU_1154313_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="240" mass="26333" checksum="107E90055F12BD6F" modified="2014-10-29" version="1">MYAGWNLCLVYARAITTTLVGVIAAIIIVINNLPAAYSCRAPEQHMNVLVISDDSGCSAELIKKGMLLPDVEGNKQYFPRDYDVTCIDGLVKKGTNTFQYIEKVTVPALRKAAQEKAGNIEELYIFVYPQSLEKQFTDYISMRFGAERARTADGWANVAENTAFSPVWAATIYHEGRHLAIHGTWHDDAGRLLPNNQINYYPGFGPSQNDNGNDAGAGLLKFLNIRPASLPGCGLSVVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNY4</accession>
    <name>A0A075MNY4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">NTE_00852</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699798.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNY4"/>
    <dbReference type="STRING" id="1459636.NTE_00852"/>
    <dbReference type="GeneID" id="41596695"/>
    <dbReference type="KEGG" id="nev:NTE_00852"/>
    <dbReference type="eggNOG" id="arCOG02363">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG02376">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_359285_0_0_2"/>
    <dbReference type="OrthoDB" id="342253at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007234">
        <property type="term" value="P:osmosensory signaling via phosphorelay pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06225">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000006">
        <property type="entry name" value="Sensor histidine kinase WalK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050351">
        <property type="entry name" value="BphY/WalK/GraS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033479">
        <property type="entry name" value="dCache_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42878:SF7">
        <property type="entry name" value="SENSOR HISTIDINE KINASE GLRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42878">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02743">
        <property type="entry name" value="dCache_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158472">
        <property type="entry name" value="HAMP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="12" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="19">
        <location>
            <begin position="325"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="17">
        <location>
            <begin position="386"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="18">
        <location>
            <begin position="459"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="16">
        <location>
            <begin position="552"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="501"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="AIF82928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="779" mass="86979" checksum="93008EFE633EB5F6" modified="2014-10-29" version="1">MHQPVFLSIRSKITFVSLFLAITTLFAVALISFISADNQLRERVSDQLISESTGRGAAIRSLIDTRIEQIRLMSTNSALQNAIAELNQNGSAASSQRMQQYRDDFTAGVESFRQVVGTPAGLENVKVMGIDGRVLFSSDRSEEGADLSHDRRFLRGVNESFLEFDQVNGQRKTIVTVPIYKNGQIGTAPAIGVMMATMDTAKFDEILLNRKGLGETGEVYLVNANRTLISESRFIENAAFRTTVNTLAVNKCFDEGAEIFAVYPDYRNIPIVGSSYCARDLGFVLLAEIDEAEIFQPVTQLRDAILIAGVIITGVVVTIALYVSKTISRPITRLRDAADKITKGDYTHRVGVESGDEIGRLAEQFDMMRKSVLETNMNLNRLVRDRTKELTDMTNALDATAIVAVTDRDGTITKVNSRFAEISKYSEQELIGQNHRILKSGYHPPAFFENMWKTITSGQIWEGEIKNRAKDGSFYWVKTTIVPFLGDDGQPKQYIAIHSDITNLKNTEERLNEALARDRANAEIIKMQVEELNVTNKELRRKDKLKDEFLSMASHELKTPLTPIIGWCDALKSNTILGKLSGEQRAAVDTIEKNAVKLEKMVSDMLDAQKLELNEFKFNIGEVDVDRVIKNVERDLEFVMKENNIEFAVNAQPGLKLRSDETRIIQVLNALLYNSVDFVPKVGGRIELTAEARDGDIVFGVRDNGPGIPKDKQRFLFKKFYQVDTSLKRKHGGTGLGLAISKGIVTGLGGQIWVDTEEGKGSSFYFSLPRETKNENPHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MP10</accession>
    <name>A0A075MP10_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RecA/RadA recombinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01189</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700055.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MP10"/>
    <dbReference type="GeneID" id="41596999"/>
    <dbReference type="KEGG" id="nev:NTE_01189"/>
    <dbReference type="eggNOG" id="arCOG08028">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1478962_0_0_2"/>
    <dbReference type="OrthoDB" id="11111at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="213" mass="23546" checksum="6447C2A9F7B9FF07" modified="2014-10-29" version="1">MAEYNLASMLSKKGLNSLLFSDPYAKLCCTSMLAGQENVVYFDLDTTFSAYLKAGLVQAPGIDVYLPSEGRFVEMLKDVLARMGEKRCSLVIFDSINSFYAMYYSYYRRSTEKGGSGGSSSSSGNINHLLSVLLMLLVRQGVTLGVPVLATSMLRFRKEGGWKQSPASRRLLQKKSATRLQVERVENEIIVQVLEHEKVPAGTSLSFGITVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MP69</accession>
    <name>A0A075MP69_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00927</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MP69"/>
    <dbReference type="STRING" id="1459636.NTE_00927"/>
    <dbReference type="KEGG" id="nev:NTE_00927"/>
    <dbReference type="eggNOG" id="arCOG01055">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_160435_0_0_2"/>
    <dbReference type="OrthoDB" id="9844at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038723">
        <property type="entry name" value="ArnR1-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14947">
        <property type="entry name" value="HTH_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ArnR1-like winged helix-turn-helix" evidence="1">
        <location>
            <begin position="6"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="99" mass="11776" checksum="DC9943FD6381CDEC" modified="2014-10-29" version="1">MVHEYRERIYIRKDIILKLYEHGELNQSKLMSYCGLNNAKHREILDEMVNKGMINRKEEPWGSKMIIKYSVSEKGKEILRAVLEPYEELFPRGDTTTND</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPB1</accession>
    <name>A0A075MPB1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integral membrane protein CcmA involved in cell shape determination</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00973</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699893.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPB1"/>
    <dbReference type="STRING" id="1459636.NTE_00973"/>
    <dbReference type="GeneID" id="41596803"/>
    <dbReference type="KEGG" id="nev:NTE_00973"/>
    <dbReference type="eggNOG" id="arCOG04555">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_705178_0_0_2"/>
    <dbReference type="OrthoDB" id="376466at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="392" mass="39719" checksum="2DA3EAEEEBBDA0F0" modified="2014-10-29" version="1">MQQDVRVERGNSATLGRVEGNLKVEKNATIEAADGSNRQVTVAGSARFRGDCTINCDFECRSLKVEKGTLRVAGNLLVHGDVDVENALYVDGSIAAEGGVAGGGIISAGSIKCRVVRVGGTLKVSDTLDAESVKVGGKVIVQKAMLVDLSVGGQAEIGSGAVQGQIRVGGTLLSKSELEFDSITVGGRVELGTAKGRGINVGGRLATTGDLACEKIKVGGIVEVGGNCSGATLEVGGETRVAGSLALTGKLGVGGDLQVKDTMTGADIGVGGRFKAGKAILTGWAWIGGQVETGAGLKAGGGIKIASHAECKGPLVGGMVELGKRCKVQDVYGSKVVAGKGAEAEKIVADEIEIHDGCTVGQTTYTRRLETGRNVTSKSASEKVASLPAFPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPD0</accession>
    <name>A0A075MPD0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00924</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699855.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPD0"/>
    <dbReference type="GeneID" id="41596759"/>
    <dbReference type="KEGG" id="nev:NTE_00924"/>
    <dbReference type="HOGENOM" id="CLU_2504798_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="85" mass="8254" checksum="DCD7886AD43A520C" modified="2014-10-29" version="1">MSSLTGNKKAFTFALLAAGFVVVSLAIATPVAFAQNATMPGGNQTGGNTTSTAFEGNPDQAPPPAPPAPGGNMTGGNQTGGNMTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPH2</accession>
    <name>A0A075MPH2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01039</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699940.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPH2"/>
    <dbReference type="GeneID" id="41596862"/>
    <dbReference type="KEGG" id="nev:NTE_01039"/>
    <dbReference type="HOGENOM" id="CLU_2203999_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="107" mass="12054" checksum="4DD1B44D9CCB2E13" modified="2014-10-29" version="1">MPYRLAILAVALVLAGTGLWLLILHVSTYTRIGTDDNDGVTAHKWRLNEKGVPELYLCNNLMCKSYSEIRWQYAGYFAIDAIVFSAAAGLVAFLFAWRRRTKAQSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPI3</accession>
    <name>A0A075MPI3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPI3"/>
    <dbReference type="STRING" id="1459636.NTE_01050"/>
    <dbReference type="KEGG" id="nev:NTE_01050"/>
    <dbReference type="HOGENOM" id="CLU_2712608_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="72" mass="8054" checksum="D819FF8A30EE9FA0" modified="2014-10-29" version="1">MHVRIEVNFYCARGIITNMSAILLLVVIPSVIAFLFSVFVAYYAFSDVSERQFSSSESDAHRLNIEVPSGQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPK9</accession>
    <name>A0A075MPK9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_00667</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPK9"/>
    <dbReference type="KEGG" id="nev:NTE_00667"/>
    <dbReference type="HOGENOM" id="CLU_2874901_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF82747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="63" mass="7036" checksum="152BC0FE598B4C0E" modified="2014-10-29" version="1">MSSCRSRNSTAAGNNRQLVSSKVILIIILYSVILVAMSEDDDFEDDFEDEEDEDTSDDDDGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQ19</accession>
    <name>A0A075MQ19_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Universal stress protein UspA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_00881</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699820.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQ19"/>
    <dbReference type="STRING" id="1459636.NTE_00881"/>
    <dbReference type="GeneID" id="41596721"/>
    <dbReference type="KEGG" id="nev:NTE_00881"/>
    <dbReference type="eggNOG" id="arCOG02053">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049301_11_1_2"/>
    <dbReference type="OrthoDB" id="105697at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00293">
        <property type="entry name" value="USP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46268">
        <property type="entry name" value="STRESS RESPONSE PROTEIN NHAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46268:SF6">
        <property type="entry name" value="UNIVERSAL STRESS PROTEIN UP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UspA" evidence="2">
        <location>
            <begin position="10"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF82957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="157" mass="17216" checksum="984DA59A16A55192" modified="2014-10-29" version="1">MSRDIKSNRIRRILVPVDGSENAFRATSFAIDLAKKYGAELVVIYALQLNQSLSYLGTYGMPTPQHIADMIQAAKKEADPWFDRIKKEADASTVKVKSEVIEAPLSIVGDIVTYAENNQFDIIVVGSRGRTGFKKILLGSIASGIVTYAHCPVLVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQ65</accession>
    <name>A0A075MQ65_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF504 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01253</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700111.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
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    <dbReference type="STRING" id="1459636.NTE_01253"/>
    <dbReference type="GeneID" id="41597059"/>
    <dbReference type="KEGG" id="nev:NTE_01253"/>
    <dbReference type="HOGENOM" id="CLU_2712971_0_0_2"/>
    <dbReference type="OrthoDB" id="8488at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="72" mass="8394" checksum="0EA6E327CDE40531" modified="2014-10-29" version="1">MTRKGRLEEIFSRALYADDPFLYFVSYRDFDSIVEVPLQEFVLLSENFSVIPASRIAKVRRGNETLYKKSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQ87</accession>
    <name>A0A075MQ87_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00972</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699892.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQ87"/>
    <dbReference type="STRING" id="1459636.NTE_00972"/>
    <dbReference type="GeneID" id="41596802"/>
    <dbReference type="KEGG" id="nev:NTE_00972"/>
    <dbReference type="HOGENOM" id="CLU_2313883_0_0_2"/>
    <dbReference type="OrthoDB" id="373333at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038723">
        <property type="entry name" value="ArnR1-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14947">
        <property type="entry name" value="HTH_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ArnR1-like winged helix-turn-helix" evidence="1">
        <location>
            <begin position="8"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="96" mass="10857" checksum="DDD961661804C265" modified="2014-10-29" version="1">MAAGRKNKRNKVEIYATILEVIRLGTDRITRISYGVGVPLDRLNVMVSDLCSFGLARKVADDEGMRYSITPRGSEFLDTYWKMKGFLEIMGNGSEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQC6</accession>
    <name>A0A075MQC6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Small ribosomal subunit protein eS28</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rps28e</name>
        <name evidence="6" type="ORF">NTE_01203</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the eukaryotic ribosomal protein eS28 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_075055812.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQC6"/>
    <dbReference type="STRING" id="1459636.NTE_01203"/>
    <dbReference type="GeneID" id="41597012"/>
    <dbReference type="KEGG" id="nev:NTE_01203"/>
    <dbReference type="eggNOG" id="arCOG04314">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_178987_2_1_2"/>
    <dbReference type="OrthoDB" id="7620at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000145">
        <property type="entry name" value="30S ribosomal protein S28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00292">
        <property type="entry name" value="Ribosomal_eS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000289">
        <property type="entry name" value="Ribosomal_eS28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028626">
        <property type="entry name" value="Ribosomal_eS28_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003080">
        <property type="entry name" value="PRK04007.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10769">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10769:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01200">
        <property type="entry name" value="Ribosomal_S28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00961">
        <property type="entry name" value="RIBOSOMAL_S28E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF83275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="72" mass="8084" checksum="968BDD01AC78CFC4" modified="2014-10-29" version="1">MSSKAAEEKVVPAEVIQIVGRTGIAGEVIQVRVKVLEGKDRGRILTRNVKGAVRMKDILMLRETEREARKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQD5</accession>
    <name>A0A075MQD5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein L16/L10E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_01680</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700457.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQD5"/>
    <dbReference type="STRING" id="1459636.NTE_01680"/>
    <dbReference type="GeneID" id="41597453"/>
    <dbReference type="KEGG" id="nev:NTE_01680"/>
    <dbReference type="eggNOG" id="arCOG04113">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084051_0_2_2"/>
    <dbReference type="OrthoDB" id="30538at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="entry name" value="Ribosomal protein L10e/L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047873">
        <property type="entry name" value="Ribosomal_uL16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018255">
        <property type="entry name" value="Ribosomal_uL16_CS_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_uL16_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001197">
        <property type="entry name" value="Ribosomal_uL16_euk_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_uL16_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003239">
        <property type="entry name" value="PRK04199.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11726">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005590">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="Ribosomal protein L16p/L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01257">
        <property type="entry name" value="RIBOSOMAL_L10E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF83741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="172" mass="19185" checksum="D3055BEB9FDB25D5" modified="2014-10-29" version="1">MKGVNYRETRGMPYVRREYIAGKPQLKIARFASGQASQDYDYKLELVVTEKIQIRHNALEAARLAANKRMATAGEMSFFSMLRVYPHVILRENKMIATAGADRLQEGMRRAFGKATGLAARVKPDQVIFEAYVTAANLPLAKEGFKVASSKLGCPTYTRVTALKPQVAKVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQG7</accession>
    <name>A0A075MQG7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methylase involved in ubiquinone/menaquinone biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="1459636.NTE_01715"/>
    <dbReference type="GeneID" id="41597484"/>
    <dbReference type="KEGG" id="nev:NTE_01715"/>
    <dbReference type="eggNOG" id="arCOG01783">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037990_2_3_2"/>
    <dbReference type="OrthoDB" id="8915at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0032259">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861:SF1">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="53"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="280" mass="30682" checksum="E2B6099B2C6CACB2" modified="2014-10-29" version="1">MAYDPTKYKQESIVSWNSRARDYHDGWAGAGRGPFRSTKELVDAAGILESDFVLDVACGTGAVSKEAFLRLGPSGMLAGIDFARGALRIAKENVPAGHFVEMDAENIGLRARFDKVLCQYALMFFPEPVRVLGELRRLLKKGGRIAVAVHGTAQGVPYFSTIMEPVLKRIPDIRPEGAPTVHRFGNPKDLENALASAGFANVAVRKFVFDYEAGPFSEYWSDYMATTAAAIRSKIEARGSQVVADIKKEAEEKAQRFVKDGKIRFPWDVLVATATSSTTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQH5</accession>
    <name>A0A075MQH5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01261</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="KEGG" id="nev:NTE_01261"/>
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    <dbReference type="Proteomes" id="UP000028194">
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="59" mass="6813" checksum="815D8A81913F199F" modified="2014-10-29" version="1">MAKIMSTTSYKKIATRFGVEPVCRYCGNPIRIGQRYYSPEKKTHGKRYHWTCAEGLSIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQP7</accession>
    <name>A0A075MQP7_9ARCH</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700556.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQP7"/>
    <dbReference type="STRING" id="1459636.NTE_01800"/>
    <dbReference type="GeneID" id="41597565"/>
    <dbReference type="KEGG" id="nev:NTE_01800"/>
    <dbReference type="HOGENOM" id="CLU_2010007_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="123" mass="14655" checksum="47B96F8112E2D9DA" modified="2014-10-29" version="1">MDKKKLKLIIEVVSAVSSVIGTIYGSILFFEHDKEYKDDMSVIEEGERLQEQYYMVSNDYYHQTISEQEYHSKLQTLIPLYEQHIDTIDRHVWRSDLAKYAISDRKIFSNDLELMKQEIRLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQU8</accession>
    <name>A0A075MQU8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01861</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQU8"/>
    <dbReference type="KEGG" id="nev:NTE_01861"/>
    <dbReference type="HOGENOM" id="CLU_1691470_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="155" mass="17364" checksum="C5A2EF30D32A93EA" modified="2014-10-29" version="1">MRREWKGTYSVYIHEMTPLQKDHAFVKLVLTDGYYSNLRGSIIVRKDDVDRLGLHEKSEIVLGVSGSDISHRQNPLAAYLDATVLGSFTQEGRNIWANYANGARYIAYANVAVKFKSVDSRGSILFRKDTFDGMEIASGDTLFLAILRVKGSLIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQY0</accession>
    <name>A0A075MQY0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 9">Peptide chain release factor subunit 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Translation termination factor aRF1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">prf1</name>
        <name evidence="11" type="ORF">NTE_01902</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 9">Heterodimer of two subunits, one of which binds GTP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the eukaryotic release factor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700630.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQY0"/>
    <dbReference type="STRING" id="1459636.NTE_01902"/>
    <dbReference type="GeneID" id="41597652"/>
    <dbReference type="KEGG" id="nev:NTE_01902"/>
    <dbReference type="eggNOG" id="arCOG01742">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035759_3_0_2"/>
    <dbReference type="OrthoDB" id="1011at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.60:FF:000003">
        <property type="entry name" value="Peptide chain release factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.960.10:FF:000003">
        <property type="entry name" value="Peptide chain release factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.960.10">
        <property type="entry name" value="eRF1 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="entry name" value="eRF1 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00424">
        <property type="entry name" value="Rel_fact_arch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024049">
        <property type="entry name" value="eRF1_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005141">
        <property type="entry name" value="eRF1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005140">
        <property type="entry name" value="eRF1_Pelota-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020918">
        <property type="entry name" value="Peptide_chain-rel_aRF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004403">
        <property type="entry name" value="Peptide_chain-rel_eRF1/aRF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03676">
        <property type="entry name" value="aRF1_eRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10113">
        <property type="entry name" value="PEPTIDE CHAIN RELEASE FACTOR SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03463">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03464">
        <property type="entry name" value="eRF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01194">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55481">
        <property type="entry name" value="N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1/Pelota-like N-terminal" evidence="10">
        <location>
            <begin position="9"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIF83961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="426" mass="47405" checksum="B89355E9964772BA" modified="2014-10-29" version="1">MVNSGNGAEKWDSVKRYKLTKMINELSSIAGHGTELVTVYVPPRRPIFDVISQLRNEAGTASNIKSDLTRNHVQDALSRTMEHLKLFKETPENGLVIFCGAIPTGKGFGTEKIELTSVIPPKPVQISLYRCDDHFWTDHLREMLKDEKVIGILAIDTQEAGLGILTGDRWEAIDSLTSGVAGKHRQGGQSARRFERLRDNELNEYYHRVADHAKAVFIDQFNVKGIIVGGPGPTKESFLKEEYLDYRLQNNVLATLDTSYSGDEGVREIIDKAQKDGILAEFRVMEEKQLVKKFMGEVHSSKGLGIYGIFDVVKALQGNMADLVLVTSDISYMKLDFKCKSCKNVQEKIIDRAALTATKQEILSKPCPVCGASDFEVVEKDIVDYLQELATMTGTRLEVISGQTEEGAQLGSLGKIGAILRYRIMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MR65</accession>
    <name>A0A075MR65_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Poly(3-hydroxyalkanoate) polymerase subunit PhaC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">PHB synthase subunit PhaC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NTE_01626</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Biopolymer metabolism; poly-(R)-3-hydroxybutanoate biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700413.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MR65"/>
    <dbReference type="STRING" id="1459636.NTE_01626"/>
    <dbReference type="GeneID" id="41597403"/>
    <dbReference type="KEGG" id="nev:NTE_01626"/>
    <dbReference type="eggNOG" id="arCOG06344">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035017_0_0_2"/>
    <dbReference type="OrthoDB" id="202878at2157"/>
    <dbReference type="UniPathway" id="UPA00917"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042619">
        <property type="term" value="P:poly-hydroxybutyrate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051321">
        <property type="entry name" value="PHA/PHB_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010125">
        <property type="entry name" value="PHA_synth_III_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01836">
        <property type="entry name" value="PHA_synth_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36837">
        <property type="entry name" value="POLY(3-HYDROXYALKANOATE) POLYMERASE SUBUNIT PHAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36837:SF2">
        <property type="entry name" value="POLY(3-HYDROXYALKANOATE) POLYMERASE SUBUNIT PHAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0583">PHB biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="8">
        <location>
            <begin position="114"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF83688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="383" mass="43570" checksum="D8A88F1A5AD643E4" modified="2014-10-29" version="1">MTQQETLPNKSEQQQQPQQPQSPVATTQPPAKIKPAEDLTREVQENFRKIEKTREILYTAGKVQVGQTPHEILAETRAYRLLHYQPLVNKTFKTPILAVYALINRSYVLDLQPDKSWIRSLLTQGFDVYLIDWKDPSTVDKYLTFDDYVNGYIDDCVNIVLKKSKTDKLTLHGYCMGASMSIMYTALHQEKVRNLAVIAPVIDTEKDSTVIGNMAKHMDVAKMVDTIGNLPPEQLFACYSALKPFKQGVAKYFNLVQNIDNEPFVGNFLRIEKWLYDTPPIAGETFREWISDIYQDNLLAKNEFYLGDLVIDLSKITVPLLNLVADEDHLVSPECSVPLNDMVSSADKRLMRFHTGHVGLIASSYSQNNVLPKVGQWLKARSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MR70</accession>
    <name>A0A075MR70_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GMP synthase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700417.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MR70"/>
    <dbReference type="STRING" id="1459636.NTE_01632"/>
    <dbReference type="GeneID" id="41597408"/>
    <dbReference type="KEGG" id="nev:NTE_01632"/>
    <dbReference type="eggNOG" id="arCOG00090">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054974_3_1_2"/>
    <dbReference type="OrthoDB" id="7388at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01741">
        <property type="entry name" value="GATase1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044992">
        <property type="entry name" value="ChyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695:SF5">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="1">
        <location>
            <begin position="42"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="229" mass="25422" checksum="77AF3D60539F4BED" modified="2014-10-29" version="1">MKKKVLSIQNVACETLGTLEGMFRKDGLAVENISAQEDGVPARSSGYSAIVVLGGPMAVYDNLPYLQKEQDLIRDAIKNDVPVLGVCLGSQLIAQAAGGRVFKGRKKEIGWHDVLLSPQGKASLFSGISEKKMRVFQWHGDTYELPRDATVLAYTDLYPQAFKVGSAIGVQFHLEVDERLIRTWMKEYDAEVRAEKIDAKRSILPAAGDLSELEKKCQVVYRNFTAMLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MR87</accession>
    <name>A0A075MR87_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01257</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700115.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MR87"/>
    <dbReference type="STRING" id="1459636.NTE_01257"/>
    <dbReference type="GeneID" id="41597063"/>
    <dbReference type="KEGG" id="nev:NTE_01257"/>
    <dbReference type="eggNOG" id="arCOG04033">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104053_0_0_2"/>
    <dbReference type="OrthoDB" id="26462at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="181" mass="20945" checksum="2B816BF3D1931673" modified="2014-10-29" version="1">MSEFLTSYPRTSIAKGIKNLIRQEEIELDHLSLMVKIKKDEIINALLSEGFKLVKLENKKPNQLGCGFAKKLSKPWEMHVRLFTVEQGLIAIQAEVEVSRKYIQHIRSARAPVIYEVEQILKKHQIEYKIWNEKIRDYITRVIDNHEIKLEAPSIPISWKQMAGYAAALGVIYLLKFASVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRA7</accession>
    <name>A0A075MRA7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <ecNumber evidence="2">4.2.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NTE_01567</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-1 OGG1 family.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="2"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700365.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRA7"/>
    <dbReference type="STRING" id="1459636.NTE_01567"/>
    <dbReference type="GeneID" id="41597348"/>
    <dbReference type="KEGG" id="nev:NTE_01567"/>
    <dbReference type="eggNOG" id="arCOG00464">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027543_3_2_2"/>
    <dbReference type="OrthoDB" id="14922at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008534">
        <property type="term" value="F:oxidized purine nucleobase lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012904">
        <property type="entry name" value="OGG_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052054">
        <property type="entry name" value="Oxidative_DNA_repair_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10242">
        <property type="entry name" value="8-OXOGUANINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10242:SF2">
        <property type="entry name" value="N-GLYCOSYLASE_DNA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07934">
        <property type="entry name" value="OGG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="10">
        <location>
            <begin position="110"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIF83630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="289" mass="32582" checksum="E3AAAF73C31D9229" modified="2014-10-29" version="1">MRQPPLLAHFDPETSVNSGQVFLWEKSGQAWYGIHADRVVKFYRQDGALVFESFPEERQIERSMFRLDDDTDSIFAEIAKDPIVKKLIASYPGLRLMRQDPAQCTISFVCASNTNIPMIRRMLGTLAKKYGQRIVADGKEFHTFPSVQALHKASEGELRACGLGYRAKAIKAAVGAMADGSLDIEYLKKAGYDEARAELLKVYGIGPKIADCILLFSLEKLDAFPIDVWIARALASHYGWLAGKKMSEKLTGHQYIEASKAARTYFGKYAGYAQQFLYYHMRQDAGKKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRF6</accession>
    <name>A0A075MRF6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF432 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01329</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385165.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRF6"/>
    <dbReference type="STRING" id="1459636.NTE_01329"/>
    <dbReference type="GeneID" id="41597128"/>
    <dbReference type="KEGG" id="nev:NTE_01329"/>
    <dbReference type="eggNOG" id="arCOG01766">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096705_0_0_2"/>
    <dbReference type="OrthoDB" id="116710at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007366">
        <property type="entry name" value="DUF432"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04254">
        <property type="entry name" value="DUF432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="247" mass="27169" checksum="AC3B554F85F6684F" modified="2014-10-29" version="1">MQELFGRHKVQAGSEPLEITFCDQKIVVGEAAGAYSYKRYSAGALAAETTIISDKDGGIVVGIFPIAPLLTPKRVAKNVYIKFKSPIIMDQRSDAVVYAKIPIEIGVYRQSEDEELLIDAFSLSPQRYALYGSPEAGTVCRLAESETSTTEEGISVEKYTEALIRIRISNGIDNVIKISKVIVPMDGIVLDHAQDDTWVPGGVDVRLDMAFGKDIVNVRANTKVKRSDKTSIVRREETLAFMMDAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRL2</accession>
    <name>A0A075MRL2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Translation initiation factor 2 subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">aIF2-alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">eIF-2-alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NTE_01737</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterotrimer composed of an alpha, a beta and a gamma chain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700501.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRL2"/>
    <dbReference type="STRING" id="1459636.NTE_01737"/>
    <dbReference type="GeneID" id="41597507"/>
    <dbReference type="KEGG" id="nev:NTE_01737"/>
    <dbReference type="eggNOG" id="arCOG04107">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033458_0_2_2"/>
    <dbReference type="OrthoDB" id="84794at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04452">
        <property type="entry name" value="S1_IF2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000015">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1130:FF:000002">
        <property type="entry name" value="Translation initiation factor 2 subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1130">
        <property type="entry name" value="EIF_2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.190">
        <property type="entry name" value="Translation initiation factor 2, subunit 1, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044126">
        <property type="entry name" value="S1_IF2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024055">
        <property type="entry name" value="TIF2_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024054">
        <property type="entry name" value="TIF2_asu_middle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011488">
        <property type="entry name" value="TIF_2_asu"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003064">
        <property type="entry name" value="PRK03987.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07541">
        <property type="entry name" value="EIF_2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110993">
        <property type="entry name" value="eIF-2-alpha, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116742">
        <property type="entry name" value="eIF2alpha middle domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="S1 motif" evidence="10">
        <location>
            <begin position="14"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIF83798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="269" mass="30330" checksum="48F1C51B38F4CF5C" modified="2014-10-29" version="1">MSSAQEASKLPDEGEIVIASVREVTGHGAYVTLDEYNGMTGFLHISEIATGWIRNIERYVRPKQKAVLKVIRVNRARGEVDCSLKQVSGEERKSKLIEVKKSEKADAFMDFIKAKLKLSDQQVAEIEEKVLQKYDYVYDIFEDIARRGPELLQKFDFSDDIKKAMEEESNKIQVPHVEVRGVMEISSKKPDGIEIIKSTLAGVESSKGNATTEVTYVGAPRYRIVVTAENFKVAEKSMNNAVEKIRSAIEKQHGAFNFIREESKKSHQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRW3</accession>
    <name>A0A075MRW3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Zinc-ribbon domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987082.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRW3"/>
    <dbReference type="STRING" id="1459636.NTE_00065"/>
    <dbReference type="GeneID" id="68225744"/>
    <dbReference type="KEGG" id="nev:NTE_00065"/>
    <dbReference type="HOGENOM" id="CLU_3227624_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026870">
        <property type="entry name" value="Zinc_ribbon_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13240">
        <property type="entry name" value="Zn_Ribbon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zinc-ribbon" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="43" mass="4656" checksum="B2CDDCE0CA1D3EB2" modified="2014-10-29" version="1">MSMEKSVGMAQQQKDRASMKYCVECGAKMPKAQKTCPACGEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MS52</accession>
    <name>A0A075MS52_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01574</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MS52"/>
    <dbReference type="KEGG" id="nev:NTE_01574"/>
    <dbReference type="eggNOG" id="arCOG06113">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2534504_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="83" mass="9608" checksum="8EDF95419F814F47" modified="2014-10-29" version="1">MSMLAVFAACPTCGNSVYEYRDGRWTEWICWRCGHYQADTPAFTAQPDLYRDIVRKNGRYFMQKYAQYAARDARSSGSRVPHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MS53</accession>
    <name>A0A075MS53_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Archaeal/vacuolar-type H+-ATPase subunit F</fullName>
            <ecNumber evidence="4">4.2.1.20</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_01934</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase F subunit family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="4"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_075053915.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MS53"/>
    <dbReference type="STRING" id="1459636.NTE_01934"/>
    <dbReference type="GeneID" id="41597683"/>
    <dbReference type="KEGG" id="nev:NTE_01934"/>
    <dbReference type="eggNOG" id="arCOG04102">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_135754_3_0_2"/>
    <dbReference type="OrthoDB" id="24971at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10580">
        <property type="entry name" value="ATPase, V1 complex, subunit F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008218">
        <property type="entry name" value="ATPase_V1-cplx_f_g_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036906">
        <property type="entry name" value="ATPase_V1_fsu_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01990">
        <property type="entry name" value="ATP-synt_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159468">
        <property type="entry name" value="AtpF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF83993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="98" mass="10638" checksum="5ED51A24BFBF034C" modified="2014-10-29" version="1">MRIIAIGSRVFVTSFQLAGVKGVKVESSAEALAEINKMGDTSDVGLVLLSDDIGKEIRTQLTTLRAKRPIPLIFELPSPGSKKEKVDYRALLKQILGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MS68</accession>
    <name>A0A075MS68_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aminotransferase</fullName>
            <ecNumber evidence="7">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NTE_01950</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="7"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385303.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MS68"/>
    <dbReference type="STRING" id="1459636.NTE_01950"/>
    <dbReference type="GeneID" id="41597697"/>
    <dbReference type="KEGG" id="nev:NTE_01950"/>
    <dbReference type="eggNOG" id="arCOG01130">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG02098">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_4_3_2"/>
    <dbReference type="OrthoDB" id="372018at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046417">
        <property type="term" value="P:chorismate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.59.10">
        <property type="entry name" value="Chorismate mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050596">
        <property type="entry name" value="AspAT/PAT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036263">
        <property type="entry name" value="Chorismate_II_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036979">
        <property type="entry name" value="CM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002701">
        <property type="entry name" value="CM_II_prokaryot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46383">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46383:SF1">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01817">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00830">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48600">
        <property type="entry name" value="Chorismate mutase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51168">
        <property type="entry name" value="CHORISMATE_MUT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 9" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Chorismate mutase" evidence="8">
        <location>
            <begin position="4"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF84008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="465" mass="51457" checksum="C61C25BF104AF629" modified="2014-10-29" version="1">MPSSQGEKDLEALRGQIRAVTSDILKKVQERMVLAEQVGEVKSRLGIDVKDEKVEQEIRQMVIKQAGETGMSIEFALRLLNVLLSESEAVQEQKRPQQNNKAPRQTHLGIFQKAKQLEASGRRIIHLEVGEPDYPAPAQAGSALAESFAQKKYHYTDTRGIPQLREAIAKKNRVGEERVMVTPGGRFAVFAAIASLVRPGEEIIAIEPAWPAYRECADFIGARTKVLKTTLESGWTPDLKELESMITSGTKMIALNYPNNPTGKVLDKKTMDRIVALAKGHGLYLLSDEVYSDYSFKPFESVHAYGYDKGVIVSSFSKTYAMTGFRVGYAVASADLIKKMAKVQAVGVTSVAEPVQLAALAALGADPSRNVELMKRRLRFLSGKLKEMSLRFVEPDGAMYVYPELHSGGEDMQLVERLLERGVAIAPGSGFGDSYRRFVRISACRNEKEMEKGLAIMADEVRKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MS70</accession>
    <name>A0A075MS70_9ARCH</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">NTE_01589</name>
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    <organism evidence="2 3">
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        <lineage>
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            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
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            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MS70"/>
    <dbReference type="STRING" id="1459636.NTE_01589"/>
    <dbReference type="KEGG" id="nev:NTE_01589"/>
    <dbReference type="HOGENOM" id="CLU_1529150_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="175" mass="19529" checksum="356CBA0F7784C961" modified="2014-10-29" version="1">MHLAYVNMDNLAEGLFDMMKKGTLKDARQIHQLFEESDSGSVFVRSSSNGGISFDEQTKLEDSKNIGLISSFATYILLLPSDRGLYALKAKHIAHPEDEQKPRFPDADVLSWHKNTGDESAAGPFKISGDSGGVSEGPRGIIVEKDNNNSEIYLVWETDWHTDHADVFFRRLQIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MS80</accession>
    <name>A0A075MS80_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01599</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_264357945.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MS80"/>
    <dbReference type="GeneID" id="75933621"/>
    <dbReference type="KEGG" id="nev:NTE_01599"/>
    <dbReference type="HOGENOM" id="CLU_3227632_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="43" mass="5015" checksum="BADCB7E9F625C9E6" modified="2014-10-29" version="1">MSEERPENGSDSRRELITKAPETPAEEIEEERAKKEKQTLSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSB0</accession>
    <name>A0A075MSB0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02411</name>
    </gene>
    <organism evidence="1 2">
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        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701033.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSB0"/>
    <dbReference type="GeneID" id="41598122"/>
    <dbReference type="KEGG" id="nev:NTE_02411"/>
    <dbReference type="HOGENOM" id="CLU_2379518_0_0_2"/>
    <dbReference type="OrthoDB" id="11298at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="96" mass="11198" checksum="A70805B809531B14" modified="2014-10-29" version="1">MPRCSVHTDFFDDSCEACRQEYLEMKGVGKEEHIIEEGGEGKKYKEFTEERAKKLFEEVMLQYLKSGSTDLEAVEKAKAVVRKQCAIRGMPYWPWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSB5</accession>
    <name>A0A075MSB5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01947</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700662.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSB5"/>
    <dbReference type="STRING" id="1459636.NTE_01947"/>
    <dbReference type="GeneID" id="41597694"/>
    <dbReference type="KEGG" id="nev:NTE_01947"/>
    <dbReference type="eggNOG" id="arCOG04219">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1357953_0_0_2"/>
    <dbReference type="OrthoDB" id="12292at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="71"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="151"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="209" mass="22069" checksum="AE2FE87A174BD57D" modified="2014-10-29" version="1">MKLFSFNASSFALDPSVEGLLKSKGAITLDFGASAYINSDAMPAILSELVAAASSSLQSSLSNAATSEALVAQLKAELAKFGAERQKLMDENTRLASQLRSHANEVAALKAQAAAAVKTVEALKAENARLQMVPKSAPPVPQAATASSDATTAVKQAYEKLQKEFQSLKAQNAEAITSLKVLEDENDELREEVEMLRSQAKSAPAPKTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSD4</accession>
    <name>A0A075MSD4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02441</name>
    </gene>
    <organism evidence="1 2">
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        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701058.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSD4"/>
    <dbReference type="GeneID" id="41598149"/>
    <dbReference type="KEGG" id="nev:NTE_02441"/>
    <dbReference type="HOGENOM" id="CLU_2419873_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="107" mass="12544" checksum="3AAB588BCEB78590" modified="2014-10-29" version="1">MKNAYEKHKNSESVKYLRKHLSRVKVLSQPVRGDVLRKALDDLDLWGEQFGIIITKLLQANGLVFDAHHYYSLHDIEKQLRRFLGKENSRQISAVIKIGIQVQYFSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSD5</accession>
    <name>A0A075MSD5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02016</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700720.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSD5"/>
    <dbReference type="STRING" id="1459636.NTE_02016"/>
    <dbReference type="GeneID" id="41597761"/>
    <dbReference type="KEGG" id="nev:NTE_02016"/>
    <dbReference type="HOGENOM" id="CLU_2243944_0_0_2"/>
    <dbReference type="OrthoDB" id="9167at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="105" mass="11771" checksum="199905C0C31CE612" modified="2014-10-29" version="1">MEIEPAARAILSNLTRGSEGASLGQIRMWLVPQKAEHEYDYSINNGYFEMLLHEALKDLMSKGYVRSSLPDGIEDGDAQVFSLTDKGTRHIEELARQAEQAAPEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MST4</accession>
    <name>A0A075MST4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nitrososphaera output domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MST4"/>
    <dbReference type="KEGG" id="nev:NTE_00327"/>
    <dbReference type="HOGENOM" id="CLU_160434_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041226">
        <property type="entry name" value="NitrOD2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18550">
        <property type="entry name" value="NitrOD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitrososphaera output" evidence="1">
        <location>
            <begin position="12"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="122" mass="13676" checksum="A47A199000F8167D" modified="2014-10-29" version="1">MEGGPMIHKLIADTENIADALLINLEATFGTRVFESISAKISEEYLGGEMDIRAAIIYRPDLFERAFIGMLGDIGERILANIWCSKLREQFELDSSVTYHKAGDLVKCIQTIRARANRRSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSU6</accession>
    <name>A0A075MSU6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02608</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701184.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSU6"/>
    <dbReference type="STRING" id="1459636.NTE_02608"/>
    <dbReference type="GeneID" id="41598301"/>
    <dbReference type="KEGG" id="nev:NTE_02608"/>
    <dbReference type="HOGENOM" id="CLU_140796_0_0_2"/>
    <dbReference type="OrthoDB" id="381584at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="129" mass="13524" checksum="33266B8AEB85FE98" modified="2014-10-29" version="1">MPDKSLAIGILAVTIVGLLSLAFSLTNSVQVNAQLIEQNPSPTATPQMLQECKEMGISLEKCSENEILKHRCLGAVGSPFGSSSGAASQPELGPFVVEILAGSGIAFVASIFGIRKLRSVKKKRLAEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MT26</accession>
    <name>A0A075MT26_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RecA-superfamily ATPase possibly involved in signal transduction</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_00392</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MT26"/>
    <dbReference type="STRING" id="1459636.NTE_00392"/>
    <dbReference type="KEGG" id="nev:NTE_00392"/>
    <dbReference type="eggNOG" id="arCOG01174">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023669_2_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014774">
        <property type="entry name" value="KaiC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010624">
        <property type="entry name" value="KaiC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43637">
        <property type="entry name" value="UPF0273 PROTEIN TM_0370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06745">
        <property type="entry name" value="ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51146">
        <property type="entry name" value="KAIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KaiC" evidence="3">
        <location>
            <begin position="17"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF82474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="243" mass="26889" checksum="0D351C0D6DA8957A" modified="2014-10-29" version="1">MPYKPIMVGYILSNSAALAKTWIPGFDSLIGGGFPRSSFIILAGHPGTGKSTFAIQFLLNGAMNAKEPGVYASFLEREEIFMRNMSKSYGFDIKKSIEENTLRFLEFTPLASEAVSDTLNKIVKTVMETGAKRLVIDSLNALFGDVPPTEQRRILEIVLNRIIKDQGCTVIAILEQSIGKTEIGFGIEEFVADGLIVFESYIEGYEAKKRAIIRKLRGTQHSSRYQAILLNPREGISFLQLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MT71</accession>
    <name>A0A075MT71_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Polyketide cyclase / dehydrase and lipid transport</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01944</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700660.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MT71"/>
    <dbReference type="STRING" id="1459636.NTE_01944"/>
    <dbReference type="GeneID" id="41597692"/>
    <dbReference type="KEGG" id="nev:NTE_01944"/>
    <dbReference type="eggNOG" id="arCOG05264">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069867_4_0_2"/>
    <dbReference type="OrthoDB" id="66844at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd07822">
        <property type="entry name" value="SRPBCC_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36166">
        <property type="entry name" value="CHROMOSOME 9, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36166:SF1">
        <property type="entry name" value="SRPBCC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="139" mass="16114" checksum="20028809179BC44A" modified="2014-10-29" version="1">MKEIYTEIEIVANARRVWEVLVDFAKYEEWNPFIRQVRGEPREGAKLEIHLTTPAGTKRTYEPKVTRVEPEKELRWFGKVPGFLSGEHIFTIEDAGNGRVKFIHREVFGGLLSSFFKDTDDVKAGFEEMNRALKARLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTD2</accession>
    <name>A0A075MTD2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02801</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701348.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTD2"/>
    <dbReference type="STRING" id="1459636.NTE_02801"/>
    <dbReference type="GeneID" id="41598489"/>
    <dbReference type="KEGG" id="nev:NTE_02801"/>
    <dbReference type="eggNOG" id="arCOG08673">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101753_0_0_2"/>
    <dbReference type="OrthoDB" id="11685at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="190" mass="21185" checksum="066499D377ADB178" modified="2014-10-29" version="1">MSGKKGKRDDSYFAADRRKKKKYVMIIVPIIAAVVAIGAVSALLYKPPEVQAISGVECHPSEITNYHVHAHLDVLVDGKNQTVPSNIGIMQSPHCLFWLHTHDDTGTIHVEAPQQRQFTLGQFMDIWKQTHSGSNSFFDSVAGKPLKAYVNGTEFQGDYKNIELKSRQQIVLAYGNPPDKIPTHDFGSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTH4</accession>
    <name>A0A075MTH4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTH4"/>
    <dbReference type="STRING" id="1459636.NTE_02030"/>
    <dbReference type="KEGG" id="nev:NTE_02030"/>
    <dbReference type="HOGENOM" id="CLU_2490276_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="86" mass="10161" checksum="26D1B7FE0D94BB59" modified="2014-10-29" version="1">MNGLKYKQSWKLILKNYGHSMKWKELVVNRMLLVMIKRRANTFFMIVQRKVLKAAEVFVTTVKGRSQGRSINQKITLLIWLCCHGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTL3</accession>
    <name>A0A075MTL3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptide methionine sulfoxide reductase MsrA</fullName>
            <shortName evidence="2">Protein-methionine-S-oxide reductase</shortName>
            <ecNumber evidence="2">1.8.4.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Peptide-methionine (S)-S-oxide reductase</fullName>
            <shortName evidence="2">Peptide Met(O) reductase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">msrA</name>
        <name evidence="4" type="ORF">NTE_00548</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-methionyl-[protein] + [thioredoxin]-disulfide + H2O = L-methionyl-(S)-S-oxide-[protein] + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:14217"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12315"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:44120"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>[thioredoxin]-disulfide + L-methionine + H2O = L-methionine (S)-S-oxide + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:19993"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58772"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MsrA Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.11" evidence="2"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987126.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTL3"/>
    <dbReference type="STRING" id="1459636.NTE_00548"/>
    <dbReference type="GeneID" id="41596416"/>
    <dbReference type="KEGG" id="nev:NTE_00548"/>
    <dbReference type="eggNOG" id="arCOG02816">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031040_10_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033744">
        <property type="term" value="F:L-methionine:thioredoxin-disulfide S-oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008113">
        <property type="term" value="F:peptide-methionine (S)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1060.10">
        <property type="entry name" value="Peptide methionine sulphoxide reductase MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01401">
        <property type="entry name" value="MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002569">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036509">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00401">
        <property type="entry name" value="msrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43774">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43774:SF1">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE MSRA 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01625">
        <property type="entry name" value="PMSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55068">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptide methionine sulphoxide reductase MsrA" evidence="3">
        <location>
            <begin position="9"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF82629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="184" mass="21278" checksum="625D647FECAADF1A" modified="2014-10-29" version="1">MMMMTTEIATLANGCFWCSEAIFRRLKGVKSVLPGYSGGKVENPSYEAVCTGRTGHAEAAQIEFDPTVISFEKLLDVFWHTHDPTTLNRQGNDVGTQYRSAIFYHDDKQREIAENSKRELEASGVYKDPIVTEIVPFKKFYVAEDYHKKYYEYHQDAQYCRFVIEPKIHKLLKQYGKDVKDELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTR8</accession>
    <name>A0A075MTR8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02981</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701488.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTR8"/>
    <dbReference type="STRING" id="1459636.NTE_02981"/>
    <dbReference type="GeneID" id="41598652"/>
    <dbReference type="KEGG" id="nev:NTE_02981"/>
    <dbReference type="HOGENOM" id="CLU_186530_0_0_2"/>
    <dbReference type="OrthoDB" id="7099at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="74" mass="8593" checksum="4E14952FC6609BD9" modified="2014-10-29" version="1">MQIKGQEPKERDIELENIVGNLLIAEYQVDKLRARLAEKVVGRGDSSANNQSIYTFKNKDKLFRVRVQIDEMEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTV3</accession>
    <name>A0A075MTV3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02524</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701122.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTV3"/>
    <dbReference type="GeneID" id="41598225"/>
    <dbReference type="KEGG" id="nev:NTE_02524"/>
    <dbReference type="HOGENOM" id="CLU_1754604_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="148" mass="16753" checksum="9ABFC240D32C8F0C" modified="2014-10-29" version="1">MDMNKKVLISIPIIGVAIFVIVVVGALNNWWRLTDVPVGFRPNNKELVKEKLGNLPEVKAFHNRYAEPNVTVLGRQVIYEKTEAQITGVQYNGTQRMEPQVTLLIDIDYDANVERMAFTCINDHGGGIQLTKDKNSILEYLEKESCFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTY2</accession>
    <name>A0A075MTY2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Endonuclease related to archaeal Holliday junction resolvase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_02561</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701147.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTY2"/>
    <dbReference type="STRING" id="1459636.NTE_02561"/>
    <dbReference type="GeneID" id="41598257"/>
    <dbReference type="KEGG" id="nev:NTE_02561"/>
    <dbReference type="eggNOG" id="arCOG05252">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1590794_0_0_2"/>
    <dbReference type="OrthoDB" id="29270at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019287">
        <property type="entry name" value="Hday_junct_resolvase-rel_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10107">
        <property type="entry name" value="Endonuc_Holl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Holliday junction resolvase-related" evidence="2">
        <location>
            <begin position="68"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF84608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="167" mass="18977" checksum="17F1A346A3E34886" modified="2014-10-29" version="1">MAALGRFIHLENRETIESLRNSELIGTCLNCGRDFPLSRAILFDGLGKFPDEAKAIRQQLLNELKEQAEELTKRKLSVEGAEQKAIYVSIGKIVEKIVPAYRDFNFPLSDCRPLFEPIDMVVFKGASNHAVDYITFLEIKTGKAQLSKREKSIKEAVEKREVSYKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTY4</accession>
    <name>A0A075MTY4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">L-aspartate aminotransferase apoenzyme /phosphoserine aminotransferase apoenzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NTE_02607</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701183.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTY4"/>
    <dbReference type="STRING" id="1459636.NTE_02607"/>
    <dbReference type="GeneID" id="41598300"/>
    <dbReference type="KEGG" id="nev:NTE_02607"/>
    <dbReference type="eggNOG" id="arCOG00082">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027686_1_1_2"/>
    <dbReference type="OrthoDB" id="35685at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008453">
        <property type="term" value="F:alanine-glyoxylate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004760">
        <property type="term" value="F:L-serine-pyruvate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019265">
        <property type="term" value="P:glycine biosynthetic process, by transamination of glyoxylate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024169">
        <property type="entry name" value="SP_NH2Trfase/AEP_transaminase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21152:SF24">
        <property type="entry name" value="ALANINE--GLYOXYLATE AMINOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21152">
        <property type="entry name" value="AMINOTRANSFERASE CLASS V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000524">
        <property type="entry name" value="SPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="6">
        <location>
            <begin position="26"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF84650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="381" mass="42209" checksum="0103C3A443D3B781" modified="2014-10-29" version="1">MEYLVMLPGPTNVPNRVMNAMLAPVINHRSDDFRVLYKEIFEKTQKVFQTTGDIVLLTTSGTGAVETSVVNLIKKGDKAVIPVNGEFSTRLADLIDSWGGQAIRIKAPFGENPPYEEFEKVFDQHKDIKALYAVYNETSTGTTIRYMDKLGQLASRKGAFFVADSVSILGGDELPVDRWNIDVCVTASQKALAAPPGVSPVSVSARAKKYMQENPPPTAYLNLKRYFKYQEEHFETPFTPALPLYYAFREALNMILEEGMDNRIRRHKICADAFYAGLNAMGLTPFAKPDARSNVVIAVNYLQGMDDKKFRGLLGEQFKVLVAGGFGDLKGKVFRVGCMGEVHKYHVMRTLSSIASAMNMIGVKANPEATSVALDRLKALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MU54</accession>
    <name>A0A075MU54_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed RNA polymerase subunit Rpo6</fullName>
            <ecNumber evidence="3">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">DNA-directed RNA polymerase subunit K</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpo6</name>
        <name evidence="3" type="synonym">rpoK</name>
        <name evidence="5" type="ORF">NTE_02193</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8 9">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the RNA polymerase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="3"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700856.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MU54"/>
    <dbReference type="STRING" id="1459636.NTE_02193"/>
    <dbReference type="GeneID" id="68225771"/>
    <dbReference type="KEGG" id="nev:NTE_02193"/>
    <dbReference type="eggNOG" id="arCOG01268">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1860765_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00192">
        <property type="entry name" value="RNApol_arch_Rpo6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006110">
        <property type="entry name" value="Pol_omega/Rpo6/RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036161">
        <property type="entry name" value="RPB6/omega-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006111">
        <property type="entry name" value="Rpo6/Rpb6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002207">
        <property type="entry name" value="PRK01099.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002208">
        <property type="entry name" value="PRK01099.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47227">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47227:SF5">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01192">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000778">
        <property type="entry name" value="RpoK/RPB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63562">
        <property type="entry name" value="RPB6/omega subunit-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3 5" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="24"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF84247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="137" mass="15300" checksum="44415A79B973A292" modified="2014-10-29" version="1">MVIKRFTKKPAARKSAVSKTKGKKGAEEEVEETKKSNRPADEVVTYSEQEYELKEVPAQGNKILIGLPWLTRFERARITGARALQLSLGAPPLIKPDGANTSIALAMLEVEKKALPISIRRILPNGMYQDIPIDWMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUA2</accession>
    <name>A0A075MUA2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701271.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUA2"/>
    <dbReference type="STRING" id="1459636.NTE_02713"/>
    <dbReference type="GeneID" id="41598403"/>
    <dbReference type="KEGG" id="nev:NTE_02713"/>
    <dbReference type="HOGENOM" id="CLU_1801760_0_0_2"/>
    <dbReference type="OrthoDB" id="374355at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="143" mass="15612" checksum="A79687108179975F" modified="2014-10-29" version="1">MKLLDGRSKQTQYNNTTYILIALQTWRVAGIVFLWGVTQGILHPAFGIPAGVGDILVGVTAIPFALFLLKGYSWSKYALVVWNVLGIADLVMAVSLGLLTSPDFGASTMTTFPWVLIPAVAVPAALALHVITLYRLRRWAQLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUE4</accession>
    <name>A0A075MUE4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative aconitase subunit 2</fullName>
            <ecNumber evidence="3">4.2.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_02685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUE4"/>
    <dbReference type="STRING" id="1459636.NTE_02685"/>
    <dbReference type="KEGG" id="nev:NTE_02685"/>
    <dbReference type="eggNOG" id="arCOG04279">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141583_2_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01356">
        <property type="entry name" value="AcnX_swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.10">
        <property type="entry name" value="Phosphohistidine domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012016">
        <property type="entry name" value="PMDh-S-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002840">
        <property type="entry name" value="PMDh-S-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01989">
        <property type="entry name" value="AcnX_swivel_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004966">
        <property type="entry name" value="UCP004966"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphomevalonate dehydratase small subunit-like" evidence="2">
        <location>
            <begin position="24"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF84728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="134" mass="13819" checksum="5179582CFF128E36" modified="2014-10-29" version="1">MITGCRRIVGGKGEGEALVSSQPINFLAMVEAKSGRITDPKHKLYGKSLKDTVLVFPNAVGSSVGAYVFYSLKEAGTAPKAIVCAKADITTASGCAIANIPVVDLPEKSSSLVSLVRPGSRIKVDADAGQIATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUF8</accession>
    <name>A0A075MUF8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Malate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NTE_02800</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the LDH/MDH superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701347.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUF8"/>
    <dbReference type="STRING" id="1459636.NTE_02800"/>
    <dbReference type="GeneID" id="41598488"/>
    <dbReference type="KEGG" id="nev:NTE_02800"/>
    <dbReference type="eggNOG" id="arCOG00246">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045401_2_2_2"/>
    <dbReference type="OrthoDB" id="2596at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004459">
        <property type="term" value="F:L-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006089">
        <property type="term" value="P:lactate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01339">
        <property type="entry name" value="LDH-like_MDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011275">
        <property type="entry name" value="Malate_DH_type3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004863">
        <property type="entry name" value="PRK06223.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43128">
        <property type="entry name" value="L-2-HYDROXYCARBOXYLATE DEHYDROGENASE (NAD(P)(+))"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43128:SF16">
        <property type="entry name" value="L-LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00086">
        <property type="entry name" value="LLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0520">NAD</keyword>
    <keyword evidence="4 9 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="10">
        <location>
            <begin position="2"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="11">
        <location>
            <begin position="145"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="7"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="116"/>
            <end position="118"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIF84840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="304" mass="32182" checksum="DCF47ECF18BDAAE9" modified="2014-10-29" version="1">MTITVIGSGKVGASAALNCGLRELDDVLLLDIVQGLPQGEAMDINHQLSERGSDSVARGSNNYEDMRGSDYVVLVAGVGRKPGMTRMDLLKINAGIVKDVASKIATYAKDATVIVVTNPLDPMTYLALKTIGAQKSKVMGMGGMLDLSRFKSYIQEATGVSRDSIQAMVISEHGENMLPLTRFSSLGGIPLHDFITKEQATDIFEKTKKVAAEVIALKGATVYAPGNAVATMIESMAKDKKMVIPVSAYLDGQYGVSDLCIGVPAVIGAGGVEKIVELKLDSFEQGVFDKGVASVREAIKALPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUG9</accession>
    <name>A0A075MUG9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, PadR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987006.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUG9"/>
    <dbReference type="STRING" id="1459636.NTE_02815"/>
    <dbReference type="GeneID" id="41598501"/>
    <dbReference type="KEGG" id="nev:NTE_02815"/>
    <dbReference type="eggNOG" id="arCOG00002">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063440_1_3_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43252">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR YQJI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43252:SF5">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR, PADR-LIKE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription regulator PadR N-terminal" evidence="1">
        <location>
            <begin position="19"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="141" mass="16539" checksum="FF579EB235A22CAA" modified="2014-10-29" version="1">MGMWMFGEMRRRRGLRMWVITLLERSPKNGAEIMDEMEMMTKGWWRPSPGSVYPLLESLVQEGFIKKREDGKYELTQRTKEDMGWPYGSHAGQPRTVEDMLKEISGYVSYFEDLVKSDKSKIEPQKEKIKEIAERLAALSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUQ0</accession>
    <name>A0A075MUQ0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00959</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699882.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUQ0"/>
    <dbReference type="GeneID" id="41596791"/>
    <dbReference type="KEGG" id="nev:NTE_00959"/>
    <dbReference type="HOGENOM" id="CLU_1182845_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="234" mass="24554" checksum="8972DDC551FD849F" modified="2014-10-29" version="1">MPGNSKKAYSSQKMITALLIATVAILSASLFLSSAGIPILQLLAPAFLIERNANAATTMTTAAVEDASSDVPILIGQQPGVSLEDSIAALCCPASIDEIHAQKVIQFTKSGGSQSEGPSPTSLAVTNTVYVNETQTLQFQFFDDVSDDATPSAFHCADIRVVVKVDGETVGVTHWLGYEGRSPPIPLSTGVITLEDISQGKHSLTLIPVTRLGGCNTEGWLYAWGGTLVVFGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MV06</accession>
    <name>A0A075MV06_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Acyl-CoA synthetase (NDP forming)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NTE_01051</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SR1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699949.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MV06"/>
    <dbReference type="STRING" id="1459636.NTE_01051"/>
    <dbReference type="GeneID" id="79064178"/>
    <dbReference type="KEGG" id="nev:NTE_01051"/>
    <dbReference type="eggNOG" id="arCOG01338">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG01340">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007415_3_1_2"/>
    <dbReference type="OrthoDB" id="18103at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043758">
        <property type="term" value="F:acetate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000020">
        <property type="entry name" value="Protein lysine acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053580">
        <property type="entry name" value="4-HB-CoA_ligase_ADP-forming"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051538">
        <property type="entry name" value="Acyl-CoA_Synth/Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043938">
        <property type="entry name" value="Ligase_CoA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032875">
        <property type="entry name" value="Succ_CoA_lig_flav_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF045493">
        <property type="entry name" value="HydDutCoALig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43334">
        <property type="entry name" value="ACETATE--COA LIGASE [ADP-FORMING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43334:SF2">
        <property type="entry name" value="ACETATE--COA LIGASE [ADP-FORMING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13549">
        <property type="entry name" value="ATP-grasp_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19045">
        <property type="entry name" value="Ligase_CoA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13607">
        <property type="entry name" value="Succ_CoA_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="10">
        <location>
            <begin position="493"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIF83124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="701" mass="75185" checksum="F361CAFA617B4F9C" modified="2014-10-29" version="1">MSNNSIFFSPKSIAVIGASEKPGVGKTIFTNIAKHFKGKIYPVTPSNPTVGGLTAYKSVLDIPESVDLAVVAAPSRFTPAVMEEVGKKGIKGAIIVSAGFKEVDEEGARLEREVGEISKKYGIRVIGPNCLGIMSLSKDNMMNSTFLKITPSYGGIALVSQSGAICAATVEDAGAQNIGFSKVISMGNKVDMDESDVLELLAEDDDTKVVVMYLEDIRNARRFMDIAKRITTEKKKPVIVLKSGRTAEGAKAAASHTGALGGSDANYEAAFAQCGVIRVDTMGELFDLATAFSKQPLPEGGVVIVSNAGGPAIISTDACSKYGLKMADISSIRDDIAKVIPAYGSPRNPVDIVGDADFNRFDKVLNLVLAHPNVGSVVTMCTPSATLNYDDLARVLVKTSRQFPNKTILASLMGLAEGVENRAIMSEGGVPYYLYAEPAIRTLKAVYDFKSWVDSAKTKAGTLSFAKDTAKVREIFASVKKQGRNNLLEEEGYEVLRAYGFPTPKSILGATEDECVKAAKEIGYPVVMKIASPDIIHKSDAGGVKVGIKSDDELRAAFRSIMENAKKYKADAKIKGVLVQEMVKSAKETILGASQDPTFGPVIMFGLGGIYVEVLKDVVFRVAPIDEREAARMVESIKTIKLLKGVRGEKPSDLKAIADSLQRLSQLVTDFPEIKEFDINPLLVLEEGKGARVVDARIILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MV07</accession>
    <name>A0A075MV07_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Dual specificity protein phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NTE_03030</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701533.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MV07"/>
    <dbReference type="STRING" id="1459636.NTE_03030"/>
    <dbReference type="GeneID" id="41598699"/>
    <dbReference type="KEGG" id="nev:NTE_03030"/>
    <dbReference type="eggNOG" id="arCOG03413">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047330_4_2_2"/>
    <dbReference type="OrthoDB" id="117569at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14504">
        <property type="entry name" value="DUSP23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000063">
        <property type="entry name" value="Dual specificity phosphatase 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050561">
        <property type="entry name" value="PTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057023">
        <property type="entry name" value="PTP-SAK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23339">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22784">
        <property type="entry name" value="PTP-SAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="8">
        <location>
            <begin position="21"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="9">
        <location>
            <begin position="86"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIF85065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="167" mass="18418" checksum="CA087E4519370E33" modified="2014-10-29" version="1">MTKLGDAYRRVRGLTSDRPSNFGWVLEGKLAGSGMPVTKAEFDWACSQGISAIVTVREGPLPEEWVNGSVDYLHLEVDDFAAPELEDIDRAVEFIDGQVAKGRPVMVHCAAGKGRTGVILAAYLVKKEGLSSQESIDKIRAMRPGSIQSDVQEWAIQMYEKYLKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MV22</accession>
    <name>A0A075MV22_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701549.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MV22"/>
    <dbReference type="STRING" id="1459636.NTE_03050"/>
    <dbReference type="GeneID" id="41598718"/>
    <dbReference type="KEGG" id="nev:NTE_03050"/>
    <dbReference type="eggNOG" id="arCOG08684">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1567206_0_0_2"/>
    <dbReference type="OrthoDB" id="8019at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046600">
        <property type="entry name" value="DUF6659"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20364">
        <property type="entry name" value="DUF6659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="173" mass="19281" checksum="B8382F45BBD0950F" modified="2014-10-29" version="1">MRAEQFSKNVLALNPKIRFAGIVEKSGHLYAGVRREDAPARLSDRSNEISLSQSAYIIDLRKIFSKELGTLQSVVYNYDTVRLVSMPIKDHILVFSTEADVSLDELTGKVQQYVKSVEGELSLYPPANIVNAEKKEALRNLLESGISEDLVAEQLDLDVNTVKALAQEMKISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MV28</accession>
    <name>A0A075MV28_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Daunorubicin resistance ABC transporter ATP-binding subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NTE_03060</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the ABC transporter superfamily. Drug exporter-1 (DrugE1) (TC 3.A.1.105) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701557.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MV28"/>
    <dbReference type="STRING" id="1459636.NTE_03060"/>
    <dbReference type="GeneID" id="41598727"/>
    <dbReference type="KEGG" id="nev:NTE_03060"/>
    <dbReference type="eggNOG" id="arCOG00196">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_2"/>
    <dbReference type="OrthoDB" id="31298at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043215">
        <property type="term" value="P:daunorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900753">
        <property type="term" value="P:doxorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000589">
        <property type="entry name" value="ABC transporter, ATP-binding subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005894">
        <property type="entry name" value="DrrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025302">
        <property type="entry name" value="DrrA1/2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01188">
        <property type="entry name" value="drrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43582">
        <property type="entry name" value="LINEARMYCIN RESISTANCE ATP-BINDING PROTEIN LNRL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43582:SF2">
        <property type="entry name" value="LINEARMYCIN RESISTANCE ATP-BINDING PROTEIN LNRL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13732">
        <property type="entry name" value="DrrA1-3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="2"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIF85095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="318" mass="35696" checksum="3FD3FCB07F26D48E" modified="2014-10-29" version="1">MIKLKSLTKRYGNNLVAVDNLTLDIEENEIFGLLGSNGAGKTTTIHMLATLLKPTSGTATVNGYDIVRQPSKVRESIGIVFQAPSSDDMLTGYENLYVHSLLYSVPRDIRKKRIDEVLELVGLSERKNDRVKTYSGGMRRRLEIARGLLHKPRVMFLDEPTLGLDPASRETMWKYVRRLVEEEKVTIILTTHYMEEADMLCDRIGVIDRGKIVALDTPARLKAALGGDIIKIKTKAKDADVIASKLDFVQKAEFVDGLLVLSVRDAKRSLPVLLQKIEAEQAEFSSPTLNDVFIHLTGRNIKEQAEGGFMERYAQYDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MV32</accession>
    <name>A0A075MV32_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">4a-hydroxytetrahydrobiopterin dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.96</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NTE_02983</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin = (6R)-L-erythro-6,7-dihydrobiopterin + H2O</text>
            <dbReference type="Rhea" id="RHEA:11920"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15642"/>
            <dbReference type="ChEBI" id="CHEBI:43120"/>
            <dbReference type="EC" id="4.2.1.96"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pterin-4-alpha-carbinolamine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.96" evidence="3"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987026.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MV32"/>
    <dbReference type="STRING" id="1459636.NTE_02983"/>
    <dbReference type="GeneID" id="68225780"/>
    <dbReference type="KEGG" id="nev:NTE_02983"/>
    <dbReference type="eggNOG" id="arCOG02939">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG08764">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_709036_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008124">
        <property type="term" value="F:4-alpha-hydroxytetrahydrobiopterin dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.20">
        <property type="entry name" value="Transcriptional coactivator/pterin dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036428">
        <property type="entry name" value="PCD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001533">
        <property type="entry name" value="Pterin_deHydtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12599">
        <property type="entry name" value="PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12599:SF0">
        <property type="entry name" value="PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01329">
        <property type="entry name" value="Pterin_4a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55248">
        <property type="entry name" value="PCD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF85018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="389" mass="43239" checksum="2B5866A9783BA058" modified="2014-10-29" version="1">MTRNIFPRKRNDDNHDDKGMNTPAAKRQGTLRLVLAIAAASMLAMFAYTGATLSQAQPQQQTAEARTLLSKVLLTKTMASSQDPAPGHETHQSAVFLPPLGEDVIYSGTLTWAASDLVELFTYHHYDGPVDGNLPPLYTEQSNNKTYASPLFFTPPDSAADHGSMNVAANAIGFHSLKGTAFTVTATFDGWTKKVALEKFSPGNATGYLATASNDKTKSSASLIPETAVNPKDMNYTILSESQIKEELTNNTELDGWRQVADNGSGKLHKTFQFKNFVQAFQFMYRVGLEAEKMNHHPDWTNNYNTVSAYLYTWSAGNKITDYDIKLAGIMKRSRRPWGDQHDCCRNWQRYYYCNSSKGGHDVWLSPRQGGLPFLHGTERRHDHRAGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MV82</accession>
    <name>A0A075MV82_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_03131</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MV82"/>
    <dbReference type="STRING" id="1459636.NTE_03131"/>
    <dbReference type="KEGG" id="nev:NTE_03131"/>
    <dbReference type="eggNOG" id="arCOG00193">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03293">
        <property type="entry name" value="ABC_NrtD_SsuB_transporters"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050166">
        <property type="entry name" value="ABC_transporter_ATP-bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42788:SF13">
        <property type="entry name" value="ALIPHATIC SULFONATES IMPORT ATP-BINDING PROTEIN SSUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42788">
        <property type="entry name" value="TAURINE IMPORT ATP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="35"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF85165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="295" mass="32864" checksum="DC3961518BE3D815" modified="2014-10-29" version="1">MQIISDALLLCSYMSLIEQQPQKEEYPRSGNNIVLELRGVSKAFLHENKTADRHRVLDGINLDVREGEFVTIVGPSGCGKSTLLNIVAGLDAPDSGLVSVRDGSDGIRKAQRVVIFQEGALFPWLTVSDNVEFGLKVAGVTKESRRATASRFIEMAQLAKFADSYIYQLSGGMKQRVAIARALALDPRILLMDEPFAALDVQTRDILHEQLVQIHQSTGKTILFVTHDINEAVLLGDRIIVLSPRTGNVKKEIAVNHPRPRDIESHEISAIRRELLRELEEDFQIAKRNHNPQEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MV87</accession>
    <name>A0A075MV87_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Yip1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MV87"/>
    <dbReference type="STRING" id="1459636.NTE_01116"/>
    <dbReference type="KEGG" id="nev:NTE_01116"/>
    <dbReference type="eggNOG" id="arCOG03769">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_153619_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="138" mass="14699" checksum="E4E6A8FFADA624FD" modified="2014-10-29" version="1">MPFGCFCCLDRSSGIESNSLLLKVTITCVANEIIYAISFVISLIVSTVIIYIVTKLFGEKEGIGRAFLAAIIGAIVYSVSYFLFGTGWLAAIIGGFVWLLALRGLYGMGWLKSLAVAVIIWVFAAIAGLLLPTVAGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVD7</accession>
    <name>A0A075MVD7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative DNA alkylation repair enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03099</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701583.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVD7"/>
    <dbReference type="STRING" id="1459636.NTE_03099"/>
    <dbReference type="GeneID" id="41598760"/>
    <dbReference type="KEGG" id="nev:NTE_03099"/>
    <dbReference type="eggNOG" id="arCOG05122">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079880_0_0_2"/>
    <dbReference type="OrthoDB" id="110299at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06561">
        <property type="entry name" value="AlkD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014825">
        <property type="entry name" value="DNA_alkylation"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34070">
        <property type="entry name" value="ARMADILLO-TYPE FOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34070:SF1">
        <property type="entry name" value="DNA ALKYLATION REPAIR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08713">
        <property type="entry name" value="DNA_alkylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="234" mass="26938" checksum="D0509D5C0B1850F8" modified="2014-10-29" version="1">MTTLVDMLRLEMQALANPVKARVLQKFFKTGPGQYGQGDVFMGIMVPASRQVARKYAAAGISLADVRTLLHSRIHEERLVALLILVQNYRGDPEGIAKFYLENLAWVNNWDLVDLTAPAILGTFLIDKERSLLYKLARSKVLWERRVSIISTHVFIRKNDFADTLKISEMLLGDSHDLMHKAVGWMLREVGKRDLAAEEEFLQKHYKKMPRTALRYAIERFSEEKRRAYMQGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVF4</accession>
    <name>A0A075MVF4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD-dependent aldehyde dehydrogenase</fullName>
            <ecNumber evidence="5">1.2.1.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_01166</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.16" evidence="5"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVF4"/>
    <dbReference type="STRING" id="1459636.NTE_01166"/>
    <dbReference type="KEGG" id="nev:NTE_01166"/>
    <dbReference type="eggNOG" id="arCOG01252">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_1_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004030">
        <property type="term" value="F:aldehyde dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07100">
        <property type="entry name" value="ALDH_SSADH1_GabD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000010">
        <property type="entry name" value="Gamma-aminobutyraldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044148">
        <property type="entry name" value="ALDH_GabD1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047110">
        <property type="entry name" value="GABD/Sad-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43217">
        <property type="entry name" value="SUCCINATE SEMIALDEHYDE DEHYDROGENASE [NAD(P)+] SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43217:SF1">
        <property type="entry name" value="SUCCINATE SEMIALDEHYDE DEHYDROGENASE [NAD(P)+] SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="4">
        <location>
            <begin position="15"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF83239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="474" mass="51728" checksum="FCAF173131585C5D" modified="2014-10-29" version="1">MGMTAEANKPVAAVVKTINPSNGEVLAEYERMSKETISKITKKSKDAFLEWRKDVHKRSEVLHQFAADFRKNKEKLARTATGEMGKPIKESRSEVEKCAWVMDFYGYNGGIFINPESVNTDANKSAIKFEPLGVIGSIMPFNFPYWQALRFASACLMAGNTVVLKPASATLQCGIEIEKTFQRIGAPEGVFQTLTGDSGVAEELIDSDVNGVTFTGSVEVGAKVGQRAVSQLKKSVLELGGSDPFIVCEDADIEKASTGAVKGRFINCGQSCIATKRFFVTRKVADEFVEKFVQKTEKLKVGDPLSDGTDIGPLASSKGLQNIDGVIKEAVRDGAEVLTGGEQIGEKGYFYRPTLLKNVTSSMRVSREETFGPVAPITIVEDEMEAVRLANDSEFGLGASIWTQDLAKAERLSNLVEAGMVTVNNVVVSDPRVPFGGIKKSGFGRELSRYGMLEFVNVKSVRFYDQLLVNHHVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVR3</accession>
    <name>A0A075MVR3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative exonuclease of the beta-lactamase fold involved in RNA processing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_03316</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVR3"/>
    <dbReference type="STRING" id="1459636.NTE_03316"/>
    <dbReference type="KEGG" id="nev:NTE_03316"/>
    <dbReference type="eggNOG" id="arCOG00541">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009673_5_1_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16295">
        <property type="entry name" value="TTHA0252-CPSF-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050698">
        <property type="entry name" value="MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203:SF52">
        <property type="entry name" value="MRNA 3-END PROCESSING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="2">
        <location>
            <begin position="8"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-Casp" evidence="3">
        <location>
            <begin position="223"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF85345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="415" mass="46432" checksum="2A965D5956A5A874" modified="2014-10-29" version="1">MGAAKEVGRSAFLASCNNTNILMDYGVLLKREPVFPMHVKPKEVDAVVITHAHLDHSGFVPSLYLSGTTDIPALGTLPTFELSELLIEDMIKLSGFYLPFEYIDVMTMLKSSKKLQYREPYMVNDAKVTLYESGHVVGGSTVTVEHEGKKLFYTGDINTRGSKLLRPADLDLGPIDMMIIESTYSQNEQTPREQSERELIEFCYEVIERGGTMFIPSFSVERAQEIACVLEHYNFKHKVVMDGMALKANEIMGRHPAFLRDPEMFKRAIGGAEWITGWGRRRKVVNEPCVIISPAGMLVGGSAIFYTQEMMGSEKNGIALVSYQGEGTPGRMLLDKRVANFDGKMKKCYADVKRFEFSGHNSRSELFEILDRVQGNPKVLTVHGDGPSCEKFAQEIKEKYGYDAHAPVQGEVVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVR7</accession>
    <name>A0A075MVR7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Imidazole glycerol phosphate synthase subunit HisF</fullName>
            <ecNumber evidence="11">4.3.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">IGP synthase cyclase subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">IGP synthase subunit HisF</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">ImGP synthase subunit HisF</fullName>
            <shortName evidence="11">IGPS subunit HisF</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">hisF</name>
        <name evidence="13" type="ORF">NTE_03204</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 15">
            <text>5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="4.3.2.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 11">Heterodimer of HisH and HisF.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11 12">Belongs to the HisA/HisF family.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.10" evidence="11"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701669.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVR7"/>
    <dbReference type="STRING" id="1459636.NTE_03204"/>
    <dbReference type="GeneID" id="41598861"/>
    <dbReference type="KEGG" id="nev:NTE_03204"/>
    <dbReference type="eggNOG" id="arCOG00617">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048577_4_0_2"/>
    <dbReference type="OrthoDB" id="6261at2157"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000107">
        <property type="term" value="F:imidazoleglycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04731">
        <property type="entry name" value="HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000006">
        <property type="entry name" value="Imidazole glycerol phosphate synthase subunit HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01013">
        <property type="entry name" value="HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004651">
        <property type="entry name" value="HisF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050064">
        <property type="entry name" value="IGPS_HisA/HisF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00735">
        <property type="entry name" value="hisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21235:SF2">
        <property type="entry name" value="IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE HISHF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21235">
        <property type="entry name" value="IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE SUBUNIT HISF/H IGP SYNTHASE SUBUNIT HISF/H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11 12" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="8 11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="11">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIF85233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="271" mass="29640" checksum="546545BBD2D04F5D" modified="2014-10-29" version="1">MTLAKRIIPCLDVDNGRVVKGVHFADVKDAGDPVELAKKYSEQGADELVFLDITASQQGRDTMKNVVRKVAMVIDIPFTVGGGIKKLEDARGILLSGADKVSINTAAVKGPELITQLMEIFGKQCVVVAIDAKRRYCEGVECKGKHTFRDKKGRRYWFEVMIYGGKEGTGLDAIAWAREVEKRGAGEILLTSIDADGTENGYDIELTRAICKASTIPVIASGGCGSPRHMREVFEKADVDAALAASIFHYEKSTVDKVKKYLKRSGVRTRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVZ7</accession>
    <name>A0A075MVZ7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Selenocysteine-specific translation elongation factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01409</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700237.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVZ7"/>
    <dbReference type="STRING" id="1459636.NTE_01409"/>
    <dbReference type="GeneID" id="41597202"/>
    <dbReference type="KEGG" id="nev:NTE_01409"/>
    <dbReference type="eggNOG" id="arCOG01564">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077867_0_0_2"/>
    <dbReference type="OrthoDB" id="30874at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001514">
        <property type="term" value="P:selenocysteine incorporation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF11">
        <property type="entry name" value="SELENOCYSTEINE-SPECIFIC ELONGATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translation elongation factor EFTu-like" evidence="1">
        <location>
            <begin position="154"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="309" mass="33240" checksum="EB9E5021AD0850D0" modified="2014-10-29" version="1">MNSVNFVVLGNPAIAGELGKKGTSTDITIYDRKTADIVYTWTVPVTFPDKIQPLMQAVNIAEYAILNVSKLDRFLGEQVLALDYSGIKDGFVLHSYEVDREKLKALLKGTSLANYQFVDGVDQLKQEMAKLVPKGQEGPVMIPVDHAFDVKGVGTVVLGVVRQGSIKAYDELTLQPSGKGVLVKSIQMHDDPVESSSSPARVGLAVKGPSAGDISRGDVICASGTVRVASGPVTAKFQKSPFFKGDLADNQMYMLSAGMQIRPVKVKLSAGEILEITPEKPMVYLPGQACVLLKPDSQTTRIIGKGIFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MW27</accession>
    <name>A0A075MW27_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ca2+-binding protein, RTX toxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NTE_01435</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MW27"/>
    <dbReference type="STRING" id="1459636.NTE_01435"/>
    <dbReference type="KEGG" id="nev:NTE_01435"/>
    <dbReference type="eggNOG" id="arCOG02508">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG07781">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_266755_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00146">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.150.10.10">
        <property type="entry name" value="Serralysin-like metalloprotease, C-terminal"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018511">
        <property type="entry name" value="Hemolysin-typ_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001343">
        <property type="entry name" value="Hemolysn_Ca-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022409">
        <property type="entry name" value="PKD/Chitinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050557">
        <property type="entry name" value="RTX_toxin/Mannuronan_C5-epim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011049">
        <property type="entry name" value="Serralysin-like_metalloprot_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38340">
        <property type="entry name" value="S-LAYER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38340:SF1">
        <property type="entry name" value="S-LAYER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00353">
        <property type="entry name" value="HemolysinCabind"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22352">
        <property type="entry name" value="K319L-like_PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00801">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00313">
        <property type="entry name" value="CABNDNGRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00089">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51120">
        <property type="entry name" value="beta-Roll"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="PKD domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00330">
        <property type="entry name" value="HEMOLYSIN_CALCIUM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="5">
        <location>
            <begin position="382"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="5">
        <location>
            <begin position="482"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="5">
        <location>
            <begin position="612"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1188"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1191"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1214"/>
            <end position="1240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF83499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="1240" mass="129604" checksum="5B0D4949CB8C01AB" modified="2014-10-29" version="1">MLMAKSVGDGKSYARNRTVSVIVFAILATSVFTTIIPSAAFAVTDPTATMNLWSPHSDSGDDGTPDDTFTFSADATASAGLQSIEWDFDGDGNVDATTPISGAPDHVNGITITHVYGDDNVYWPQVRAVDVNSSVSDWSRYSVGGSNTPLDVFWPPPVITMLQWSPFAADVNLPITFSATAFNPVGVQLFEWDFDGDGEPDATSPATPFGAPNASSSIVHTYTGAIASFPKVRALDNDDFLSYWDVYDVNGQPVQLVIGSSSVPTATLDQWNPYSASGPDGLPDTAFTFSASGTADAGIAHLEWDFDGDGNVDATTSVSGAPTSVSSVTTTHTYNAAGMWTPKVRVVDVNGLPSSWAAFMTGGSPVKLDTAAPQMGPTLNFSPRAPSDIGFDGSTATAFTFTVTYFQHPVSFKWDFNGNGVIDEITTQPTTTHTYPVYGSYLPTVTVVDEWGTSELAFPVNSSNAQEDVDVSPAAPTATLNQWNPYSASGADGNENTTFTFSADASAPAGIARLEWDFDGNGTVDMTTPISGAPTLVSAITATHVYGSDGNYTPKVKAVDVDGRASAWDAFNSGSTVPTLDVASPPANSTPVANAGPDQIVIVGSTVTLDGTGSSDADPGTTLTYMWAQNTGPVTLVINASTNPAKPTFVASTAGTYTIELRVKDQLGATSTPDTVVITVVNAPIATMNQWNPYSSSGPDGTPTTVFTFSADASAPAGIVRLEWDFDGNGSVDATTIVTGSPTSVTGVTKTFTYGADGIYTPKVRVVDAGNNVSAWDTFNSGTTIIQLDVVTPQTSDLYCDGKTIDQLIASHQYNVIDKRNTSVVNIYGTSGNDLILGNNLSNYIDGRGGDDCIIAFGGDDTVYDYNGDSSAGGTDWLYGGDGNDKLYALNGDDYVYGGNGNDYIQGSYGNDKLYGEAGDDTIEDVNGNDLSDGGAGIDKCTDSQGTNDTIINCELGQPPVATLNQWNPYSASGADGTPTTAFAFSASATSATNAGIAKFEWDFNGDGNVDATTPITGSPMSATATASYTYNAAGTWTPKVRAVDIYNQVSAWDAFNSGSTIIKLDTSLPSSGDLYCDGKTIKQLIASGQYHVIDNRNGQRKTLNGSNGNDLILASKYGDVINAKKGNDCVIGGAGDDIIHGHQGDDQIYGNGGNDRIFGDDGADKLYGGSGNDVIYGDNGNDVIVGGAGNDDISGGNGSNTIDGSDGNDGCDDDRGRSNMRNIERNYRNDHRDDDHDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MW69</accession>
    <name>A0A075MW69_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701802.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MW69"/>
    <dbReference type="STRING" id="1459636.NTE_03360"/>
    <dbReference type="GeneID" id="41599007"/>
    <dbReference type="KEGG" id="nev:NTE_03360"/>
    <dbReference type="HOGENOM" id="CLU_838375_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="331" mass="36468" checksum="73B41C81D7E74F4E" modified="2014-10-29" version="1">MGMQNNANHHWNATRIIMMTTLLLFLVLVPLPLLPVSQSSAIFFMADRSVIHPHNNIASAVAASSITTTNMDDQTGASSQQISSLLAVRTITESLGYRELVGIPLIFSHQGNVSIKETPAKINIPNDVQNYTITAPDMLFRNFDNVTFDHWQDDTNSTDRTKTIAISDNNGRGISEDLTAVYRWYTAACDSCRAFLREGFVEPLVIRIVDSEGNLLTGAKVTVAPKTVASQSSSGFSPIATFSSLKNATTYVVSVPATFVGNNFVSMSNNGSSSSNDGSNNRSIYHFDHWQGIDGYYHNDRNTNHILATIYSSNHFFSNYEITLTAVYEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWJ0</accession>
    <name>A0A075MWJ0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02982</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_193354076.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWJ0"/>
    <dbReference type="STRING" id="1459636.NTE_02982"/>
    <dbReference type="GeneID" id="59387793"/>
    <dbReference type="KEGG" id="nev:NTE_02982"/>
    <dbReference type="HOGENOM" id="CLU_3094231_0_0_2"/>
    <dbReference type="OrthoDB" id="12414at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="56" mass="6161" checksum="2F1BC15DF0C100F9" modified="2014-10-29" version="1">MVSSQTILKQEEEDASEGVPVCSANYSSPVVDQASFIEEIHYSIGGKKYIENAPHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWK7</accession>
    <name>A0A075MWK7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">succinate dehydrogenase</fullName>
            <ecNumber evidence="5">1.3.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">NTE_01591</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">SR1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate metabolism; tricarboxylic acid cycle.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="5"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700386.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWK7"/>
    <dbReference type="STRING" id="1459636.NTE_01591"/>
    <dbReference type="GeneID" id="41597371"/>
    <dbReference type="KEGG" id="nev:NTE_01591"/>
    <dbReference type="eggNOG" id="arCOG00962">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044838_3_3_2"/>
    <dbReference type="OrthoDB" id="144910at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1060.10:FF:000003">
        <property type="entry name" value="Succinate dehydrogenase iron-sulfur subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="entry name" value="Alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050573">
        <property type="entry name" value="SDH/FRD_Iron-Sulfur"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004489">
        <property type="entry name" value="Succ_DH/fum_Rdtase_Fe-S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025192">
        <property type="entry name" value="Succ_DH/fum_Rdtase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00384">
        <property type="entry name" value="dhsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004616">
        <property type="entry name" value="PRK05950.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11921:SF29">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] IRON-SULFUR SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11921">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE IRON-SULFUR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13085">
        <property type="entry name" value="Fer2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46548">
        <property type="entry name" value="alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="13" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="16">
        <location>
            <begin position="42"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="17">
        <location>
            <begin position="169"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="AIF83654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="280" mass="31902" checksum="36CFAC4494DF6AAD" modified="2014-10-29" version="1">METIEKIERLDKKRAEGHHKHREIQRTSITLKVLRGNRAAGERTKYDLFEVPVQRSTTVLDALLYAKQYQDHSIGIRYSCRMASCGSCGMKINGIPRLACYTKVSELEGGVITVEPLANFPHIRDLVTDFEQFFAHHKNMQPYIHNDEADMDTKQVNRMSEFMQSPDDVDKFLQFSYCIKCGLCYSACPTVATDTRFPGPQALAQAYRYFIDNRDNASKERLDKVDDRHGIFRCHFAGSCSTVCPKGVDPALGIQLLRGHLLGFSSNEKKKAELKDRSKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWK9</accession>
    <name>A0A075MWK9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Neurotransmitter-gated ion-channel transmembrane region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_03485</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_420835315.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWK9"/>
    <dbReference type="STRING" id="1459636.NTE_03485"/>
    <dbReference type="GeneID" id="41599113"/>
    <dbReference type="KEGG" id="nev:NTE_03485"/>
    <dbReference type="eggNOG" id="arCOG09466">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075232_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="299"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="3">
        <location>
            <begin position="200"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF85513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="319" mass="35419" checksum="92C2267755BE45D3" modified="2014-10-29" version="1">MGLVPLNPFHSIKEAYGQTTTPDDSNSGGIASSAAEPERLSAGVYLLNIGKVDLQTGSYDLDFYFWLASASNSTVDFTKQKPTFDFMNSMNAKIEPSRIEPNYYEVRVKGTFLKNMDFRNYPFDTQEVTVEVEGFETVDKLVFVPDTVSSGYDSLVNVPGWNLGKTEQSVIVHQYPDQSYSRYIFSFDIQRAALSAFLKTIFPVIIITTIAMLAFWMSPTNFPPRIGLAASTLLAAVAAHLAAASQLPPIGYLTLMDKVMIVAYALFLNNLVSMVLQMRLVDHKKEEQAAKVNAKMRKLMPVIIGVILAVLVPFDLRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWN8</accession>
    <name>A0A075MWN8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Membrane protein TerC, possibly involved in tellurium resistance</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NTE_03510</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987066.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWN8"/>
    <dbReference type="GeneID" id="41599132"/>
    <dbReference type="KEGG" id="nev:NTE_03510"/>
    <dbReference type="eggNOG" id="arCOG09430">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045644_1_2_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005496">
        <property type="entry name" value="Integral_membrane_TerC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022369">
        <property type="entry name" value="Integral_membrane_TerC_rswitch"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03718">
        <property type="entry name" value="R_switched_Alx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30238">
        <property type="entry name" value="MEMBRANE BOUND PREDICTED REDOX MODULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30238:SF0">
        <property type="entry name" value="THYLAKOID MEMBRANE PROTEIN TERC, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03741">
        <property type="entry name" value="TerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF85538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="354" mass="39720" checksum="7386988F8C1171CA" modified="2014-10-29" version="1">MLPDGNYYYYILWLVFGLFVGAALAIDLGVISKMRFRRKESTSSSKIPDQENCPVQEEIGTNITFRRALHWTIAWISLAGVFALIIYLGRGYGSLLEFVSAYTLEKSLSVDNMFVFAIIFSSLAIPHKYQHKVLFLGILGAISMRIPLILAGTTLLENFHWMLYVFGGLLLVTALRMALQRREKETIDIKRNVAVRLLRRLVPITSTLREDKFLFRSTRGVLYATPMLVALVVVELTDLIFAMDSIPAVLAITTDPFIVITSNIFAILGLRSLYFLLAGLMDRFYYLKPALIALLVLVGAKMLFSDFYKIPIEASLAAIFAILGSAVGLSIAKTRIGDKNALKNKQQSDKDNKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWX4</accession>
    <name>A0A075MWX4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GTP:adenosylcobinamide-phosphate guanylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWX4"/>
    <dbReference type="STRING" id="1459636.NTE_03118"/>
    <dbReference type="KEGG" id="nev:NTE_03118"/>
    <dbReference type="eggNOG" id="arCOG01871">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098907_0_0_2"/>
    <dbReference type="OrthoDB" id="9782at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MobA-like NTP transferase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="199" mass="21229" checksum="86BC2B52AFD4E3AD" modified="2014-10-29" version="1">MQQQPETEKPMTELAGRRFVERVALALKESGRFERIVAAVSPSTPATKEFLLSTAEDIAETIDTPGAGYPQDLAILLEKLAPAKVLVVPADVPLLTAAIVSEIVDKLAAVGAPAASIAIEKSFAESIGVAPSVAFGDLCHSGITLFDSTRAKGTAMMVEERYVIMNRVEVALNVNTKREKEVAESLVKRANDLAGNNRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MX24</accession>
    <name>A0A075MX24_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01773</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MX24"/>
    <dbReference type="STRING" id="1459636.NTE_01773"/>
    <dbReference type="KEGG" id="nev:NTE_01773"/>
    <dbReference type="HOGENOM" id="CLU_2475837_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="87" mass="10184" checksum="3BF10AD7C97449D3" modified="2014-10-29" version="1">MPKNSPYTTRTGRMIARTGCLGTKCFIIFLSKLLLVSGYMVMRRFVWKVQIRENESRPWRDDDVPKTVEVPDFKTGNGVLPSWHLYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MXS8</accession>
    <name>A0A075MXS8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_02042</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700738.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MXS8"/>
    <dbReference type="STRING" id="1459636.NTE_02042"/>
    <dbReference type="GeneID" id="41597782"/>
    <dbReference type="KEGG" id="nev:NTE_02042"/>
    <dbReference type="eggNOG" id="arCOG05599">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055419_0_0_2"/>
    <dbReference type="OrthoDB" id="15372at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023917">
        <property type="entry name" value="Bifunctiontional_GlmU_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050065">
        <property type="entry name" value="GlmU-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03991">
        <property type="entry name" value="alt_bact_glmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43584">
        <property type="entry name" value="NUCLEOTIDYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43584:SF9">
        <property type="entry name" value="TRANSFERASE HEXAPEPTIDE REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13562">
        <property type="entry name" value="NTP_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF84099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="419" mass="45676" checksum="3DF8DD1DD1DA2B92" modified="2014-10-29" version="1">MPSIALFEDHHWRNFSPLTLTKATFDLKVGARTFFEECTYAGNAPDALLVRRHLEKVTAERHDGCKVNDPGAFDADTIFVNGLLHPATLDLPRLSRVSHTFAITSANRLLVARLSKKSAEYLQKCVEAGKPASIKALAVEKSTDTQSAEGLLSEPWDLTRLLENALAMQTVAAEQQQSSETMQGIKVLGQNAVVTEGAAIEEGTVLDARNGGIYIGPGAYISQSRIVGPAYIGSQTQVKQFSIIEKSYVGRNCRVAGEIEHSIVSDYTNKAHDGFLGHSYVGEWVNLGAMTTTSDLKMTYGNIRIEGRNTGLDKLGSFFADMSKTSIGTLIYSGRRIGVSSHLHGLVSGDVPSFTIYGKGIGAKNVELELASAIETQRKVMPRRGQQMSKAYEQMIKDVFLSTAQERKKAGVRRAKFAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MY24</accession>
    <name>A0A075MY24_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator with CheY-like receiver domain and winged-helix DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_02124</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385372.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MY24"/>
    <dbReference type="STRING" id="1459636.NTE_02124"/>
    <dbReference type="GeneID" id="41597852"/>
    <dbReference type="KEGG" id="nev:NTE_02124"/>
    <dbReference type="eggNOG" id="arCOG02589">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_8_2"/>
    <dbReference type="OrthoDB" id="9652at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050595">
        <property type="entry name" value="Bact_response_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44591:SF3">
        <property type="entry name" value="RESPONSE REGULATORY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44591">
        <property type="entry name" value="STRESS RESPONSE REGULATOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="2"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF84179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="123" mass="13852" checksum="CB73613524F34DAC" modified="2014-10-29" version="1">MEILIIDDDPDITETLADYFRERGEVCRVYNNGEDGLKAMSSEGSFDVALLDLSMPGINGFDSLRALAYKGILRRKPVFVITAMDISPESEKLMRDAGVMKVFRKPFSPESLAKTLETYHKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MYB0</accession>
    <name>A0A075MYB0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YdhG-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MYB0"/>
    <dbReference type="STRING" id="1459636.NTE_02190"/>
    <dbReference type="KEGG" id="nev:NTE_02190"/>
    <dbReference type="eggNOG" id="ENOG502N58B">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131962_0_0_2"/>
    <dbReference type="OrthoDB" id="379622at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014922">
        <property type="entry name" value="YdhG-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08818">
        <property type="entry name" value="DUF1801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159888">
        <property type="entry name" value="YdhG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YdhG-like" evidence="1">
        <location>
            <begin position="22"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="126" mass="14236" checksum="52FD031C543665F6" modified="2014-10-29" version="1">MNKNNPSKLIDKQIADMADWRGEMLAKLRKLVHEADPSLKEEWKWNTAVWTHDNGLVCAAGAFKDHIKINFFKGASLEDPHKLFNAGFEAKATRAIDFHEGDGINESALKDLIRAAVAYNNNKMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N030</accession>
    <name>A0A075N030_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TRASH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02814</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701359.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N030"/>
    <dbReference type="STRING" id="1459636.NTE_02814"/>
    <dbReference type="GeneID" id="41598500"/>
    <dbReference type="KEGG" id="nev:NTE_02814"/>
    <dbReference type="eggNOG" id="arCOG04507">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_185152_1_1_2"/>
    <dbReference type="OrthoDB" id="37898at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="entry name" value="Ribonucleotide Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011017">
        <property type="entry name" value="TRASH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007029">
        <property type="entry name" value="YHS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04945">
        <property type="entry name" value="YHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00746">
        <property type="entry name" value="TRASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRASH" evidence="1">
        <location>
            <begin position="4"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="45" mass="5102" checksum="4454AA106775F235" modified="2014-10-29" version="1">MPKDPICGMEVSEESKFKSRKGGQTIYFCCPHCKSKFDVDPAKFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N077</accession>
    <name>A0A075N077_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02866</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N077"/>
    <dbReference type="STRING" id="1459636.NTE_02866"/>
    <dbReference type="KEGG" id="nev:NTE_02866"/>
    <dbReference type="eggNOG" id="arCOG08678">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_127465_0_0_2"/>
    <dbReference type="OrthoDB" id="8006at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="135" mass="15742" checksum="DD71B7807E45B051" modified="2014-10-29" version="1">MCALCGRELKHKYKPKDEWQIEGYLCSDCHIEKMKEFASRPSQQQKQEEPDHCAVCKAELGDVAVKARWQWEMEPGTLLCQPCFNKKEAEYTKRLNFCATCGAKMGFIRYNPKPAWKIKGQMCRKCWDARNSQGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N094</accession>
    <name>A0A075N094_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02881</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0166 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
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        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="8505at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR003793">
        <property type="entry name" value="UPF0166"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35983">
        <property type="entry name" value="UPF0166 PROTEIN TM_0021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35983:SF1">
        <property type="entry name" value="UPF0166 PROTEIN TM_0021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02641">
        <property type="entry name" value="DUF190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="GlnB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="103" mass="11629" checksum="92EF97030ECD8611" modified="2014-10-29" version="1">MKMKMWTLTIIFKRNDEVRGKKLYIKLLDFLKDAGILGATVWTGVDGFGKRGRSSTKLEGITVNMPVLIEIIDERSKIEPILPQIKRMVGDNGILTIQEVLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N1B7</accession>
    <name>A0A075N1B7_9ARCH</name>
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        <recommendedName>
            <fullName evidence="3">Clan AA aspartic protease, AF_0612 family</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N1B7"/>
    <dbReference type="STRING" id="1459636.NTE_03230"/>
    <dbReference type="KEGG" id="nev:NTE_03230"/>
    <dbReference type="eggNOG" id="arCOG03744">
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="110" mass="11888" checksum="9637509FBB0A80F8" modified="2014-10-29" version="1">MGIIDAGSNKKIVVDAHLDFASSKTIIPTYIANDMNLSFAGSDETVTGAGIIHIPYYEVSIEVFGQLYESVHVGCLDLPEGTPAKALLGRDILDNYRICLDGRNKEITVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N1U7</accession>
    <name>A0A075N1U7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_03401</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701842.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N1U7"/>
    <dbReference type="STRING" id="1459636.NTE_03401"/>
    <dbReference type="GeneID" id="41599047"/>
    <dbReference type="KEGG" id="nev:NTE_03401"/>
    <dbReference type="HOGENOM" id="CLU_1253522_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF85429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="220" mass="21343" checksum="8299616D847FB923" modified="2014-10-29" version="1">MSSVVLSPLVTTAGPSSLFPLFGLGGNVPEGSLGDSINKATLKALDNIRAAVGISGFVVDNAVATPKAKDVSKSSSTGGNAPSGGGGGGGMSRGSGAGDDKPPAAGRPARLSDFKTALKIGATGAAVAGAGLAVNETAKQLGQTANDAVATTGEVIKNISDSVGKGLDSASQAVGDALSPITDPLGLSDPETRKNIGGLVIGVLVVGIIGFGLFMVMSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ML50</accession>
    <name>A0A075ML50_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00072</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ML50"/>
    <dbReference type="KEGG" id="nev:NTE_00072"/>
    <dbReference type="HOGENOM" id="CLU_1998649_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="124" mass="13899" checksum="E0F1891F3D3A5B57" modified="2014-10-29" version="1">MLSVAVVAIVLAAIFVMPSQRIFSTRIPAVVQSRDYTHISEELIMNNRGLRTALECADSHYEILKRTGSQTQNPISADPSCETKISAYDASMIKSQIPVFSLDGHYLYQVEHEGKYHTILMLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLI7</accession>
    <name>A0A075MLI7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphohistidine phosphatase, SixA</fullName>
            <ecNumber evidence="2">3.1.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00049</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.-" evidence="2"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLI7"/>
    <dbReference type="STRING" id="1459636.NTE_00049"/>
    <dbReference type="KEGG" id="nev:NTE_00049"/>
    <dbReference type="eggNOG" id="arCOG01992">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084603_3_1_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101006">
        <property type="term" value="F:protein histidine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051021">
        <property type="entry name" value="Mito_Ser/Thr_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004449">
        <property type="entry name" value="SixA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00249">
        <property type="entry name" value="sixA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20935">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20935:SF0">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE PGAM5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="186" mass="20210" checksum="13D80719E3C032E0" modified="2014-10-29" version="1">MIYAPALSAPVELYILRHGEAGKRLAAGSKDSERPLTVAGEQEVKEIAGALVDLGIKLDFVAASPLARARQTAEIVVKKLKVKKGKFELWNELKPEGSRLALYSKLAQFKPGDSVMVVGHEPYLSSLVGDLMFDSQGSSSGGGSNGRIVLKKAGLARVSVTSLRPRARGELRWLLTPRHMRRMMTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLM3</accession>
    <name>A0A075MLM3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATPase (AAA+ superfamily)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00299</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699376.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLM3"/>
    <dbReference type="GeneID" id="41596204"/>
    <dbReference type="KEGG" id="nev:NTE_00299"/>
    <dbReference type="HOGENOM" id="CLU_641928_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="427" mass="47478" checksum="84743141182EB047" modified="2014-10-29" version="1">MVEITMGNVWEDLGFTGNPYDPRALSISDEDRKLLIDRTNELQMLTTLVNSGKGITIVEGGIGVGKTSLVNAMQYDLLHQKKNTILPAFQKIELTDGNMEPKNFILSTFSNMIFSLEKLTNTDLAKQTGILKEGKLLVAQTIQSGFAGNLQAFGFGGGMSRSPSTTHPAAVTLPAILNTMDKWVEYVSKNTEYDGPVVIPVNNMDILDDKEIVSFLNSMRDTLIDRPHIVWILIGRKGLFSLLESEARRVSEIITGQPVVLQPLTLQDVYNAIKIRVKLLSLNKKSRDGGIVSDEIVKILYDASQGEIRYVFKRITDIILKFRGQFPSVSQIPLDVAKSMIIDFAKSRIDALNLSSKELAVLKSIVKKGSMRTKEYQSVGLQTPQALNKYLASFYKQNLVVKEYGEGRAVYYRPTADTIFALQDAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MM64</accession>
    <name>A0A075MM64_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane-bound metal-dependent hydrolase (DUF457)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_338031178.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MM64"/>
    <dbReference type="STRING" id="1459636.NTE_00266"/>
    <dbReference type="GeneID" id="41596176"/>
    <dbReference type="KEGG" id="nev:NTE_00266"/>
    <dbReference type="eggNOG" id="arCOG04605">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1076056_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007404">
        <property type="entry name" value="YdjM-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04307">
        <property type="entry name" value="YdjM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="258" mass="28436" checksum="ACAA884A3F64D8C5" modified="2014-10-29" version="1">MVAFLIAYAVSRMLVTSEDKRRRLAGTTKIALALVMLLGILPDTDIVFQAFGIIPHKTFTHSVILSAFLVAPAIFVVARWPLKQTLAASLAYALAYAQHLFDDIIVGTLNVAYPFGTIPVGIGIAYGSVYHLALEIVLVAAVAAIVMKGSFGKTRKQSESFGQRSNNYYSLYRLHLFGFGKVDKVCYALLMLSLLVSFAYLLQEMKSIPRLFIESDLEVALFVILHLSALALVSFMILVSRENAKPEPSSREETVRDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMB3</accession>
    <name>A0A075MMB3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00188</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158384906.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMB3"/>
    <dbReference type="GeneID" id="43502541"/>
    <dbReference type="KEGG" id="nev:NTE_00188"/>
    <dbReference type="HOGENOM" id="CLU_200166_0_0_2"/>
    <dbReference type="OrthoDB" id="9048at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="58" mass="6503" checksum="24D1CF04FBE15FB4" modified="2014-10-29" version="1">MVKPFAVRPAKIALRKKITHCSNCSVEVATVEALFKIEGAVFVRKYCQKCLADAEFEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMI1</accession>
    <name>A0A075MMI1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ammonia monooxygenase/methane monooxygenase, subunit C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00376</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699428.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMI1"/>
    <dbReference type="STRING" id="1459636.NTE_00376"/>
    <dbReference type="GeneID" id="41596263"/>
    <dbReference type="KEGG" id="nev:NTE_00376"/>
    <dbReference type="eggNOG" id="arCOG08699">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1444620_0_0_2"/>
    <dbReference type="OrthoDB" id="5728at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22188">
        <property type="entry name" value="arch-AMO_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.50">
        <property type="entry name" value="Particulate methane monooxygenase subunit c2. Chain: C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006980">
        <property type="entry name" value="NH3_CH4_mOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023349">
        <property type="entry name" value="NH3_CH4_mOase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04896">
        <property type="entry name" value="AmoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="187" mass="21129" checksum="6B723842AF942197" modified="2014-10-29" version="1">MAQMPALIPKEVEIQRLKKIYIFCIVLGSIAASVEVDNFVDGSLHQTTIRDSAFTPAHWWLYSHFVALPLGWGMVAMYCRRIPVLRGPGNSLNTGLKITILGYLATMFTIGVNELWHFWFVEEIFAVPNHWMFNMGVVVAFMGALAFVVRVYARLVELGAETPARNPYVAEMYKLALEGKLYSRSIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMI9</accession>
    <name>A0A075MMI9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribonuclease VapC</fullName>
            <shortName evidence="8">RNase VapC</shortName>
            <ecNumber evidence="8">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Putative toxin VapC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">vapC</name>
        <name evidence="10" type="ORF">NTE_00268</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Toxic component of a toxin-antitoxin (TA) system. An RNase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the PINc/VapC protein family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="8"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMI9"/>
    <dbReference type="KEGG" id="nev:NTE_00268"/>
    <dbReference type="eggNOG" id="arCOG02219">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118482_3_2_2"/>
    <dbReference type="OrthoDB" id="11240at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:RNA nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09881">
        <property type="entry name" value="PIN_VapC4-5_FitB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00265">
        <property type="entry name" value="VapC_Nob1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050556">
        <property type="entry name" value="Type_II_TA_system_RNase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022907">
        <property type="entry name" value="VapC_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33653">
        <property type="entry name" value="RIBONUCLEASE VAPC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33653:SF1">
        <property type="entry name" value="RIBONUCLEASE VAPC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0800">Toxin</keyword>
    <keyword evidence="2 8" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="domain" description="PIN" evidence="9">
        <location>
            <begin position="2"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="5"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIF82350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="127" mass="14246" checksum="57BD78A79FFB60A9" modified="2014-10-29" version="1">MVCFDTDFLVAYIRKDPAAKCKLEELESTQEPLHTTIINAFELYKGAYKSKDSNTELARVDKLLDAFFLLALDRDSAKAAGALNDKSNPIGESDLLIASIVLANKQVLITRNKKHFERISGLKVEDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMJ2</accession>
    <name>A0A075MMJ2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699434.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMJ2"/>
    <dbReference type="GeneID" id="41596269"/>
    <dbReference type="KEGG" id="nev:NTE_00386"/>
    <dbReference type="HOGENOM" id="CLU_084395_0_0_2"/>
    <dbReference type="OrthoDB" id="12176at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="253" mass="28056" checksum="6EA180B7C168D7FB" modified="2014-10-29" version="1">MIPVAASLTTEQYNSSASSKKADEYAIEVGTSPEMHKECQSRHEILKELEDLGVNSEELASVSIDSLAGLLKGLHALIDAHSEQHRRRPGRPKRSESDMPVLTKSDKTILHHLFSSQGHVSSLKLSRELDIPLSTIQRRRKRLQDGLLETHYSLRIEKLGWRSATLLISTTNRAIESIGTEILGMSDLVSSVSRAMGGSNFDLRVEVVFKTNADLMTLIDRIKLTEGVSGIIWSESLKLIGKKDTNDKIINST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMU4</accession>
    <name>A0A075MMU4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699440.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMU4"/>
    <dbReference type="GeneID" id="41596276"/>
    <dbReference type="KEGG" id="nev:NTE_00393"/>
    <dbReference type="HOGENOM" id="CLU_113981_0_0_2"/>
    <dbReference type="OrthoDB" id="384460at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="207" mass="23657" checksum="8277B54EEFF4EADB" modified="2014-10-29" version="1">MPQDYDNSHILHVIESALELIGKGSKQVILDYLNVRYGMNTKLIVDYKDEFENYLRETIGDSAEIIISKIDATLYESRNNNNNRYNDNCNNNTNGNGHHNHNHNHNKNTNTTVLQEQKRSVSGKPAGYERKRITDVVHFLICDSCFWCASVLRECHEPKCLSCGSKIVSTVPVMSNEKFLVEVDEKRGISLSFREVGINKQQVVKPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MN53</accession>
    <name>A0A075MN53_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pvc16 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_00499</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699527.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MN53"/>
    <dbReference type="STRING" id="1459636.NTE_00499"/>
    <dbReference type="GeneID" id="41596372"/>
    <dbReference type="KEGG" id="nev:NTE_00499"/>
    <dbReference type="HOGENOM" id="CLU_052029_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025351">
        <property type="entry name" value="Pvc16_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14065">
        <property type="entry name" value="Pvc16_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pvc16 N-terminal" evidence="2">
        <location>
            <begin position="23"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF82580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="431" mass="48626" checksum="B23D458ABB3F890E" modified="2014-10-29" version="1">MSVNQYEIVAVTAAFWYILELDGDPKLKVTLKSPDGKEDGNTSRNWVNVFLYRVSENPGYYGSDLPTRNDRRELVHRPELWLDLHYLVTAYGEKDDDMQAQIAMAIAARKLHERQLLLRQDLETILTTSEVKAKFPGIDQFVLPDQVRHTTITRENLSLEDLTKLWSSFFKTSPYHLSAGYKATTVLLQGRTGEQRTPSPVRDRNVYVIAARSPEIAYIQPQIVEYAANGMEVDIIGQNLRADDVRLDYGRGVTKQEEETLNREKLEDLRFDRMEKLDLDLVRGERITLQIPNPSQSPIFSTAGVKKLKVVHPLNLGTPRKPHRGPESNTAVFAVAPKITVAKLDAPNNQRLVVEFEPPAKKEQKVTVILGSLAPIEVKLNNDASKVEVDLPPAIKKGTYPVRLQIDRAESQPGTDPPNNSEYGRPTVDIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNC8</accession>
    <name>A0A075MNC8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">glycine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Diadenosine tetraphosphate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NTE_00981</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SR1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.1.1.14" evidence="1"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNC8"/>
    <dbReference type="STRING" id="1459636.NTE_00981"/>
    <dbReference type="KEGG" id="nev:NTE_00981"/>
    <dbReference type="eggNOG" id="arCOG00405">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015515_2_1_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006426">
        <property type="term" value="P:glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.230:FF:000005">
        <property type="entry name" value="Glycine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027031">
        <property type="entry name" value="Gly-tRNA_synthase/POLG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002315">
        <property type="entry name" value="tRNA-synt_gly"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00389">
        <property type="entry name" value="glyS_dimeric"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003211">
        <property type="entry name" value="PRK04173.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745:SF0">
        <property type="entry name" value="GLYCINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745">
        <property type="entry name" value="GLYCYL-TRNA SYNTHETASE/DNA POLYMERASE SUBUNIT GAMMA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01043">
        <property type="entry name" value="TRNASYNTHGLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="9">
        <location>
            <begin position="7"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIF83056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="495" mass="56633" checksum="38C762153217B7E2" modified="2014-10-29" version="1">MSTSNYDKVMKLALERGFYFPSCEIYSDAPAGFWEYGPTGVSMKNKFIELWRRELVRRDGMMEIDGCQIMSKSVFVASGHLGNFTDPIVKCTKCGSIFRADRFIEEKTDERVPERLSNEDIDALIKKHGLKCQNCKGELGNVSRFNMMFRVGIGPAGEEAYLRPETCQTIFVDFSRVFKTMRGRLPLGIAQIGKSFRNEIAPRQSLLRLREFYQAEIEVFCNPAKLDDMPRFDEVKGTTLRLFRDGDSEITALTAEQAIAKGLVPNKLVAYYLALLTEFYEKTGIDITKSRFRRLSDEEKAFYASVAFDFEVQTSTGWLELVACNYRSDYDLKGHATTSKQKLEVVDPSDQQKVLPHVFELSMGIDRSLYTILEHSYYEEQVKDETRAVLKLKPYLAPVLVGVLPLMTKDGLGEKARRIHSELKLDFDSFYDESGSIGRRYRRLEEVGAPFAITVDPQTMQDDTVTVRHRDSMQQERVRTGELAGFMRASLQIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MND8</accession>
    <name>A0A075MND8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Plastocyanin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_00991</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699905.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MND8"/>
    <dbReference type="STRING" id="1459636.NTE_00991"/>
    <dbReference type="GeneID" id="41596819"/>
    <dbReference type="KEGG" id="nev:NTE_00991"/>
    <dbReference type="eggNOG" id="arCOG02926">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_978666_0_0_2"/>
    <dbReference type="OrthoDB" id="11836at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028096">
        <property type="entry name" value="EfeO_Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052721">
        <property type="entry name" value="ET_Amicyanin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36507">
        <property type="entry name" value="BLL1555 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36507:SF1">
        <property type="entry name" value="BLL1555 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13473">
        <property type="entry name" value="Cupredoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="EfeO-type cupredoxin-like" evidence="2">
        <location>
            <begin position="203"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF83066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="285" mass="28881" checksum="D80474218EE1D98B" modified="2014-10-29" version="1">MSHEHEHDSEPVLRTSPARMARGIAIVGITLAIAGTILMFTFKDMIANPPPVALIKKPTPPPPPPAAGVTQISIPSGASVQGSTSYDPGDAKVPLGNKVVWNNADNAIHTATSGTGASDPNVGKAFDTSLINPGEKSKEIEITGAKVGDSFAYHCTVHPFMTGKITIVEAAAGGGSTGSGSGGAAASGPTVHILSGSSVQGAKAYDPTPVEIKKGDKLTVVNDDSAIHTVTSGTGAEDANAGKAFDSSLLDPGKTVSVDTSALAAGSYDFHCMVHPFMKGKLNVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNG2</accession>
    <name>A0A075MNG2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TRUD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_01017</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase TruD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNG2"/>
    <dbReference type="STRING" id="1459636.NTE_01017"/>
    <dbReference type="KEGG" id="nev:NTE_01017"/>
    <dbReference type="eggNOG" id="arCOG04252">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005281_4_1_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1510.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.20">
        <property type="entry name" value="TruD, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001656">
        <property type="entry name" value="PsdUridine_synth_TruD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011760">
        <property type="entry name" value="PsdUridine_synth_TruD_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042214">
        <property type="entry name" value="TruD_catalytic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326:SF21">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE PUS7L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01142">
        <property type="entry name" value="TruD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037016">
        <property type="entry name" value="Pseudouridin_synth_euk_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50984">
        <property type="entry name" value="TRUD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRUD" evidence="3">
        <location>
            <begin position="168"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF83091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="426" mass="47988" checksum="E3D42C7D332A0E6F" modified="2014-10-29" version="1">MLSPSSSPPVPEIDMMAGIECYCSADFSGIGGSIKQDSSSFQVSELVDESSLGISKEFEGAYRYPLYLLQKEGVDSNHALFEIEREHRLRLRVMGIKDAKAVTSQYAGAERAWQNAPKELRTRHTMLTLQGFTKRPLGRELLAGNEFSIAIQNPMRDDISGFENQVQNIANFYGLQRFGSERLVTHLVGRAIVKKDFARAAELLLTYTTKYDTDSSREIRRKCLDPSGYRQALKEVPRGMDIERQLLSALVAGKGPVQALRAVPIQIRRLFVQAYQAYIFNMCLSRAIAQGEDITSPKQGDLCFEMEGPFAFGRIKKYDPSLLSDKQQFVPAVRMAGYTFQPGRGRFEEITKELLVQEGVAAKDFYVKEMQELSQQGGFRQAPLWCQDFAWKKNPLTVSFKLPKGSYATTLLRELIKPQDPIKAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNX7</accession>
    <name>A0A075MNX7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC-type dipeptide/oligopeptide/nickel transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NTE_00772</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cell membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987142.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNX7"/>
    <dbReference type="STRING" id="1459636.NTE_00772"/>
    <dbReference type="GeneID" id="41596623"/>
    <dbReference type="KEGG" id="nev:NTE_00772"/>
    <dbReference type="eggNOG" id="arCOG00751">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036879_1_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="entry name" value="MetI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30465:SF45">
        <property type="entry name" value="BINDING-PROTEIN-DEPENDENT TRANSPORT SYSTEMS INNER MEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30465">
        <property type="entry name" value="INNER MEMBRANE ABC TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="MetI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="8">
        <location>
            <begin position="126"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF82850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="349" mass="38417" checksum="7A862560DE2ED2E0" modified="2014-10-29" version="1">MVGGFGRFLIRRSANMLIVLFATLVLTIALLGPTMDKILTDATRFSIVDEVNHGNLKFQSAQERQKYIDDRVQLQIKTLGLDEPWYSPKRFTNTVLKVMTLDLGRSNFFTSDSGSSSVRDIILEKMPKTVLLFTTSTLVITVIGLYLGAYVANKSGSVLDRLNSAFAVFSGSFPTWWVGILMIFAFAFTYHIFPARATPLTSPSDPAYVPDLLYHMVLPLITIVAVGFGSWAYIVRYFVVGILGEDYIAAKRAAGVPEKRIIYSHALKNAAPPIVTVIALSLAGSFGGAITVEAVFDWPGMGKLYYDAIGFLDIPVIIGLTYVATVIFVITVFVTDIVYAYFDPRVKVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNY0</accession>
    <name>A0A075MNY0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF2024 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00847</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699794.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNY0"/>
    <dbReference type="GeneID" id="41596690"/>
    <dbReference type="KEGG" id="nev:NTE_00847"/>
    <dbReference type="eggNOG" id="arCOG08720">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_188388_0_0_2"/>
    <dbReference type="OrthoDB" id="5685at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.510.10">
        <property type="entry name" value="NE1680-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018592">
        <property type="entry name" value="DUF2024"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023122">
        <property type="entry name" value="NE1680-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09630">
        <property type="entry name" value="DUF2024"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160766">
        <property type="entry name" value="NE1680-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="109" mass="12386" checksum="BBBC59034408E20F" modified="2014-10-29" version="1">MQLEPYHGGRKKVVVYNTYADGGRLHFDVFIPTDKSNAGQVSKDMDAQAVEYAKEFLKLIGKQSTGDNMMVNICERCHIDDTSLYSNELWQLPGKEVFIWPMEGCPKPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNZ0</accession>
    <name>A0A075MNZ0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00857</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699803.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNZ0"/>
    <dbReference type="STRING" id="1459636.NTE_00857"/>
    <dbReference type="GeneID" id="41596700"/>
    <dbReference type="KEGG" id="nev:NTE_00857"/>
    <dbReference type="HOGENOM" id="CLU_192648_0_0_2"/>
    <dbReference type="OrthoDB" id="374052at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="84" mass="8975" checksum="DB932F0E337491FD" modified="2014-10-29" version="1">MSNNQKNTGSIPGKDLGRAMNNLRKSLGPTVVDLLITDLQRQGITLAGGESYSIKQVEGALKKTFGQDGGELLTDMISKSLQEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MP68</accession>
    <name>A0A075MP68_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00879</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987248.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MP68"/>
    <dbReference type="STRING" id="1459636.NTE_00879"/>
    <dbReference type="GeneID" id="41596720"/>
    <dbReference type="KEGG" id="nev:NTE_00879"/>
    <dbReference type="eggNOG" id="arCOG02242">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2152487_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002831">
        <property type="entry name" value="Tscrpt_reg_TrmB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01978">
        <property type="entry name" value="TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription regulator TrmB N-terminal" evidence="1">
        <location>
            <begin position="2"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="111" mass="12687" checksum="1464C092161140C1" modified="2014-10-29" version="1">MYDLSSSDMALLALLLREAKPQTLDELADSMDRDRGTAFRSLQRLVSLGFCTKQTVNLKEGGYKHLYSSAGIEQIEKNAEHRVKEIRSSLNRLMKKFRQDIRYMAAATSEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MP82</accession>
    <name>A0A075MP82_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription initiation factor IIB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NTE_00521</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TFIIB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MP82"/>
    <dbReference type="STRING" id="1459636.NTE_00521"/>
    <dbReference type="KEGG" id="nev:NTE_00521"/>
    <dbReference type="eggNOG" id="arCOG01981">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043736_0_1_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20550">
        <property type="entry name" value="CYCLIN_TFIIB_archaea_like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000023">
        <property type="entry name" value="Transcription initiation factor IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.170:FF:000001">
        <property type="entry name" value="Transcription initiation factor IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023486">
        <property type="entry name" value="TFIIB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618:SF13">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="Zn_Ribbon_TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00782">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TFIIB-type" evidence="8">
        <location>
            <begin position="2"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor TFIIB cyclin-like" evidence="7">
        <location>
            <begin position="106"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor TFIIB cyclin-like" evidence="7">
        <location>
            <begin position="197"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00053882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF82602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="292" mass="32568" checksum="5913360171D3AE34" modified="2014-10-29" version="1">MVTDPESGEIICSRCGLVSQDMLTDGRAEWRVFGLDDNNNNKNNNRQRVGSPNSLAFHDMGLSTIIGTDSRDSTGHKLDASMNSAMQRLRTWDFRSLSSSSANRNRMKAFSELGRLKDKLGLSDAIVEKTAYIYRKAQQKQLIKGRAIPSILAAALYIACREMGAPRSLHETAEITNVKSKALSHHYKLLIRELDIKVPLIDPVRYIAKIANKTRIQEKTQRTAIDIMNNIVKKEISAGKNPVGLAATVLYVSCLDNDEKITQREIADAAGVTEVTVRNRFKDLKVHLLCVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MP94</accession>
    <name>A0A075MP94_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Translation initiation factor 2 subunit alpha (AeIF-2a)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NTE_00531</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987123.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MP94"/>
    <dbReference type="STRING" id="1459636.NTE_00531"/>
    <dbReference type="GeneID" id="41596403"/>
    <dbReference type="KEGG" id="nev:NTE_00531"/>
    <dbReference type="eggNOG" id="arCOG04107">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033458_0_2_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04452">
        <property type="entry name" value="S1_IF2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1130:FF:000002">
        <property type="entry name" value="Translation initiation factor 2 subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1130">
        <property type="entry name" value="EIF_2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.190">
        <property type="entry name" value="Translation initiation factor 2, subunit 1, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044126">
        <property type="entry name" value="S1_IF2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024055">
        <property type="entry name" value="TIF2_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024054">
        <property type="entry name" value="TIF2_asu_middle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011488">
        <property type="entry name" value="TIF_2_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07541">
        <property type="entry name" value="EIF_2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110993">
        <property type="entry name" value="eIF-2-alpha, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116742">
        <property type="entry name" value="eIF2alpha middle domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="S1 motif" evidence="6">
        <location>
            <begin position="19"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF82612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="284" mass="31379" checksum="3E5EA8C92DB473EF" modified="2014-10-29" version="1">MSSRSEIKPSHEQPLPEEGDIVIATIKDVTGHGAYVSLDEYDGLTGFLGIREVATGWVRNIQRYIRPRQKAVLKVIRVNKARAEVDTSLKQVSGEERKEKLIEIKKSEKASGFMDTIKVVAGLNDAQLQQITDLALQKYDDLYSLFETVAIKGIDSIKNLGFDAKVLEAIEGESKKIQVPLVEVRGILEISSKKPDGIEIIKNILLDAEKSKSGSSGGRAEINIAYIGAPKYRLTIKAENFKIAEKALTNATEKIENAMRKHNGTFSFTREESKKKASSANTTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPG0</accession>
    <name>A0A075MPG0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPG0"/>
    <dbReference type="KEGG" id="nev:NTE_01373"/>
    <dbReference type="HOGENOM" id="CLU_3282668_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="40" mass="4703" checksum="515A148681E1F0BF" modified="2014-10-29" version="1">MTVLAIVFVIFYVLPNLHIPLIILILNGYITNWNNILAYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPH0</accession>
    <name>A0A075MPH0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal-protein-alanine acetyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.128</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_00612</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.128" evidence="4"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699612.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPH0"/>
    <dbReference type="STRING" id="1459636.NTE_00612"/>
    <dbReference type="GeneID" id="41596475"/>
    <dbReference type="KEGG" id="nev:NTE_00612"/>
    <dbReference type="eggNOG" id="arCOG00833">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_23_0_2"/>
    <dbReference type="OrthoDB" id="43754at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004596">
        <property type="term" value="F:protein-N-terminal amino-acid acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006464">
        <property type="entry name" value="AcTrfase_RimI/Ard1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045047">
        <property type="entry name" value="Ard1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01575">
        <property type="entry name" value="rimI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091:SF4">
        <property type="entry name" value="N-TERMINAL AMINO-ACID N(ALPHA)-ACETYLTRANSFERASE NATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="12"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF82692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="166" mass="18982" checksum="813ADFB8B0EE0117" modified="2014-10-29" version="1">MQTALRKVGDDYVIRRCEESDLQAVIDINMAALPEHYSDYFFESILRELPEAFIVAEMGGKVIGYIMCKIEFGFSNFRKLGFVKKGHVVSVAVLDEHRGKGVGKALMLEGINGVLHRKADEIYLEVRVSNTSAIKMYERLRFETKSRLRSYYRDGEDAYLMALELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPL0</accession>
    <name>A0A075MPL0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPL0"/>
    <dbReference type="STRING" id="1459636.NTE_01001"/>
    <dbReference type="KEGG" id="nev:NTE_01001"/>
    <dbReference type="eggNOG" id="arCOG10517">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_736932_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.50">
        <property type="entry name" value="Particulate methane monooxygenase subunit c2. Chain: C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023349">
        <property type="entry name" value="NH3_CH4_mOase_C_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="341"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="381" mass="40614" checksum="693690819088E83C" modified="2014-10-29" version="1">MTDQSVIFINDCTVLTAMSLKLSTSRMNILLAALLVATAGGILQIGGASWDITSHILRQPETFFTPSHAVLYTGAGLTVIAATIGLFVFLKNKEEIRSRSFNTAFKLLIVGAAIQLVSGPGDFMWHSVFGVDGLMSPPHLSLATGILIGTIATVVGLARILPHIESKRNQGFAKIAMVPAFAALWFSTIWYIFFFVLPLSNGQHFTFNPDPAAAIVIATTVLPFMSALIFLVSARTIGRLGAATAVAGAVISMNVLANIVPAYQFLGSFLPWQLLALIPAIVGADIAIHKARPRTGMMIAGALIGITFYVFNYPMLPMAFAEILHQPNASFADILPSMYPTLWQVIGMTAVPSALAGIIGAIMGSKIIEKPQARVISATKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPN0</accession>
    <name>A0A075MPN0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein uL10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Acidic ribosomal protein P0 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpl10</name>
        <name evidence="6" type="synonym">rplP0</name>
        <name evidence="8" type="ORF">NTE_00712</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699692.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPN0"/>
    <dbReference type="STRING" id="1459636.NTE_00712"/>
    <dbReference type="GeneID" id="41596565"/>
    <dbReference type="KEGG" id="nev:NTE_00712"/>
    <dbReference type="eggNOG" id="arCOG04288">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053173_0_0_2"/>
    <dbReference type="OrthoDB" id="30930at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.105.20:FF:000001">
        <property type="entry name" value="60S acidic ribosomal protein P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00280">
        <property type="entry name" value="Ribosomal_uL10_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050323">
        <property type="entry name" value="Ribosomal_protein_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040637">
        <property type="entry name" value="Ribosomal_uL10-like_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043164">
        <property type="entry name" value="Ribosomal_uL10-like_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022909">
        <property type="entry name" value="Ribosomal_uL10_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17777">
        <property type="entry name" value="RL10P_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL10-like insertion" evidence="7">
        <location>
            <begin position="116"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF82792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="295" mass="32444" checksum="9118CD4CA9CF873E" modified="2014-10-29" version="1">MSTTQVVQRKSYPKKKRVMYQELQELPKSYNVIALSKMNKVRASQLMLIRKKFRNDIKIRIIKNKVAQRAFEKVQGVAGLENLSKELEGQCALMFTNISPFKLNLAFSQNKIFLPAKGGDIATKEIVVPAGNTGIAPGPVLSEFKVANVQTKIDQGTIWVNKDTVVAKPGDVISQQLASLLSKLNIKPIEAGITVNFAIAEGLLFKEADLRINLAEYKDELVRSFQQALALATEAGYMTPETVKPLLVKAQQHARSLAAESGYLTKDTADIVLPRAQSKAQAVASEAKKKGYTAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPN5</accession>
    <name>A0A075MPN5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Translation initiation factor 1A</fullName>
            <shortName evidence="2">aIF-1A</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">eif1a</name>
        <name evidence="5" type="ORF">NTE_00723</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-1A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPN5"/>
    <dbReference type="STRING" id="1459636.NTE_00723"/>
    <dbReference type="KEGG" id="nev:NTE_00723"/>
    <dbReference type="eggNOG" id="arCOG01179">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109098_1_2_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05793">
        <property type="entry name" value="S1_IF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00216">
        <property type="entry name" value="aIF_1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001253">
        <property type="entry name" value="TIF_eIF-1A"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003084">
        <property type="entry name" value="PRK04012.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003085">
        <property type="entry name" value="PRK04012.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21668">
        <property type="entry name" value="EIF-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00652">
        <property type="entry name" value="eIF1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2 3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1-like" evidence="4">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF82802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="88" mass="10145" checksum="79911BBB3A134CE8" modified="2014-10-29" version="1">MVMPQQGELLGRVIKLVGGDNIIVKCTDGKVRTCRIRGKIKRRMWIRDNDLVLVAPWDFQSERADIIWRYISAHAEKMKAEGHLQGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPP2</accession>
    <name>A0A075MPP2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_01467</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700288.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPP2"/>
    <dbReference type="STRING" id="1459636.NTE_01467"/>
    <dbReference type="GeneID" id="41597260"/>
    <dbReference type="KEGG" id="nev:NTE_01467"/>
    <dbReference type="eggNOG" id="arCOG04351">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_456074_0_0_2"/>
    <dbReference type="OrthoDB" id="8914at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019204">
        <property type="entry name" value="DUF2070_membrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09843">
        <property type="entry name" value="DUF2070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2070" evidence="2">
        <location>
            <begin position="14"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF83531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="598" mass="63516" checksum="C429CC94F6BBBC05" modified="2014-10-29" version="1">MLAAKQDDDVSNIHRRWSFTRITPGSLRSSYAMMLACAAVVIIVSHIFHLQTDLLALAVHLPLGLAVLVGLTYLDFIMLKGTPVNKMSKVVHVASFANLLWAITVIVGVLASAVFAKPPETTGYIVAGMLLAAGLRIGIFVSVFGAGMGRAVAICLVQPLVFFLAFVPAQSYDIIYDPVGLGFGAVFVALAISWATIVDRAGRPEISSTFRVLQAFLSAWTENKPGGLEEYFESRAHDESVSTKVISFISQGGPAGSRSPSSIILPDIHPGPFGSVGGSNLPYVLYERFGRSALVMHSVSDHSLNIPSKAEVERYVGSLSRAVIESRGKTCSLPVQHRQGNATVTAIAFGRSALVMLSLAPKGMEDVPQSVRKELESYAAGLGMDHLLLVDCHNAMGAQLDGQDTSDIISAAKKCLDEAGKSAQAEFSVGFASLADARHHHGNSLQGAHDLGQSGLAVMAISTQGMTYAIGWADSNNMDNALRDKVVARAKEGTTIMLEVCSSDTHSTSGKRTSEGYFPLGGASSQDAIADAYAEMCNIAQERAGPCTYEVASARSEVKVMGEKQFQDYSGALDRAMNITKVFVGTTVAVFIAMQVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQ00</accession>
    <name>A0A075MQ00_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphate transport regulator related to PhoU</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00866</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0111 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699810.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQ00"/>
    <dbReference type="STRING" id="1459636.NTE_00866"/>
    <dbReference type="GeneID" id="41596709"/>
    <dbReference type="KEGG" id="nev:NTE_00866"/>
    <dbReference type="eggNOG" id="arCOG02640">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086031_0_1_2"/>
    <dbReference type="OrthoDB" id="145921at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="entry name" value="Phosphate transport system protein phou homolog 2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018445">
        <property type="entry name" value="Put_Phosphate_transp_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052912">
        <property type="entry name" value="UPF0111_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37298">
        <property type="entry name" value="UPF0111 PROTEIN YKAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37298:SF1">
        <property type="entry name" value="UPF0111 PROTEIN YKAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01865">
        <property type="entry name" value="PhoU_div"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="212" mass="24158" checksum="03764D34B96F26FF" modified="2014-10-29" version="1">MAGGGFLSWIRSNDREIIDALEQQGANVLKAANALVDLVSNFENVGERKVNIKDIEHRGDEIAHNIYLIMDKTFVTPLDREDISKLTSEVDEILDYIDGAADRFVLFKISKPTPYMIELAKILLSATQEVHTLMMRLRGFKNSADLIEHCRNINKYEHEADTIYRLAIAELFDTSDAIEIIKFKEIYLQLEDAVNRCQDVADTFEDIGLKYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQ49</accession>
    <name>A0A075MQ49_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01624</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQ49"/>
    <dbReference type="STRING" id="1459636.NTE_01624"/>
    <dbReference type="KEGG" id="nev:NTE_01624"/>
    <dbReference type="HOGENOM" id="CLU_2911318_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="61" mass="7154" checksum="2D500338CB30C705" modified="2014-10-29" version="1">MKWIKGIPSVRVNLCRFLVQYKKDVSTHEGVYEMIEKPIDRTCNNHIGVILTYRQIFTAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQ61</accession>
    <name>A0A075MQ61_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">siroheme decarboxylase</fullName>
            <ecNumber evidence="4">4.1.1.111</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NTE_01248</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>siroheme + 2 H(+) = 12,18-didecarboxysiroheme + 2 CO2</text>
            <dbReference type="Rhea" id="RHEA:19093"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:60052"/>
            <dbReference type="ChEBI" id="CHEBI:140497"/>
            <dbReference type="EC" id="4.1.1.111"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Ahb/Nir family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.111" evidence="4"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700107.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQ61"/>
    <dbReference type="STRING" id="1459636.NTE_01248"/>
    <dbReference type="GeneID" id="41597054"/>
    <dbReference type="KEGG" id="nev:NTE_01248"/>
    <dbReference type="eggNOG" id="arCOG01628">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049427_0_0_2"/>
    <dbReference type="OrthoDB" id="145939at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3460">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040523">
        <property type="entry name" value="AsnC_trans_reg2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050684">
        <property type="entry name" value="HTH-Siroheme_Decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053953">
        <property type="entry name" value="NirdL-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43413:SF1">
        <property type="entry name" value="SIROHEME DECARBOXYLASE NIRL SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43413">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR, ASNC FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17805">
        <property type="entry name" value="AsnC_trans_reg2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22451">
        <property type="entry name" value="NirdL-like_HTH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Siroheme decarboxylase NirL-like HTH" evidence="7">
        <location>
            <begin position="11"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="Siroheme decarboxylase AsnC-like ligand binding" evidence="6">
        <location>
            <begin position="67"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Siroheme decarboxylase NirL-like HTH" evidence="7">
        <location>
            <begin position="182"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Siroheme decarboxylase AsnC-like ligand binding" evidence="6">
        <location>
            <begin position="239"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF83318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="331" mass="38341" checksum="2AE023021F210FC8" modified="2014-10-29" version="1">MQANQQLDEMDKKLLNDIQWVFPLADRPYLKIAKNYNISEDEVMRRISGLKGAGLIRQINAIFDTRRLGYKSALIAFAVRPKKLDAVAEKVNEHPGVSHNYERNHEYNMWFTLAVPPDSDMKEELDRMAALDGVVKYRLLPTLKMYKIGVKLDMVNGDAEKPKPTDEVKELNPDKLEITERDKEYVRELQKDLPVVKEPFKEMAQNLGITTAELFAKAREYEKVGLMRRFAAILRHRDAGFVANGMVVWNVPEERVDDVGFKLAAFPQVSHCYRRPVYPDWKYNVFSMVHARSLEAAEKMAVEMSGQIGISDYKILFSSREFKKERVKYFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQ97</accession>
    <name>A0A075MQ97_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative membrane-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NTE_01294</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
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    <dbReference type="STRING" id="1459636.NTE_01294"/>
    <dbReference type="GeneID" id="41597097"/>
    <dbReference type="KEGG" id="nev:NTE_01294"/>
    <dbReference type="eggNOG" id="arCOG03117">
        <property type="taxonomic scope" value="Archaea"/>
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    <dbReference type="OrthoDB" id="204088at2157"/>
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    </dbReference>
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        <property type="entry name" value="VTT_dom"/>
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    <dbReference type="PANTHER" id="PTHR42709">
        <property type="entry name" value="ALKALINE PHOSPHATASE LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UNDECAPRENYL PHOSPHATE TRANSPORTER A"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
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    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="VTT" evidence="7">
        <location>
            <begin position="48"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF83363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="226" mass="23725" checksum="C58606FDB8057502" modified="2014-10-29" version="1">MRAILAIIVLASAGLLAQIADGISVLIVQYGYPAVFAAAFLEMIFPPIPSEIVFPLVGFTAQSNGLGLQNALGMAAVGALGSTAGAIIIYLAAMKIGRAAILRYGRYIRMGEDDLKKAEGWFAKYGSLAVFAARMVPGIRELISIPAGIGGMKLARYTVFTFAGSLVWSTALTLVGFYVGAAWSAVAEELSSAFTVIGTVVLAGLAATVVIWYARRKNKKSARQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQD7</accession>
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        </submittedName>
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            <taxon>Nitrososphaerales</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="STRING" id="1459636.NTE_01218"/>
    <dbReference type="GeneID" id="41597027"/>
    <dbReference type="KEGG" id="nev:NTE_01218"/>
    <dbReference type="HOGENOM" id="CLU_1933167_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="130" mass="14557" checksum="8A6514352ED826D4" modified="2014-10-29" version="1">MIQNIIKKKDPKYVTVYVNKNLTGTIESKIQQLAELGILPPNTTKAKFIKHAVGFYLANFSEGNIAGLQAYQTSHKEHGIGKNAKDLYAEIKLETFRAVQTKLAHEIEWIKKQNTMAPSISKLLNSGDTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQI2</accession>
    <name>A0A075MQI2_9ARCH</name>
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        <submittedName>
            <fullName evidence="10">PMT family glycosyltransferase, 4-amino-4-deoxy-L-arabinose transferase</fullName>
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    </protein>
    <gene>
        <name evidence="10" type="ORF">NTE_01730</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQI2"/>
    <dbReference type="STRING" id="1459636.NTE_01730"/>
    <dbReference type="KEGG" id="nev:NTE_01730"/>
    <dbReference type="eggNOG" id="arCOG04615">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_622037_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016763">
        <property type="term" value="F:pentosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050297">
        <property type="entry name" value="LipidA_mod_glycosyltrf_83"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038731">
        <property type="entry name" value="RgtA/B/C-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33908">
        <property type="entry name" value="MANNOSYLTRANSFERASE YKCB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33908:SF11">
        <property type="entry name" value="MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13231">
        <property type="entry name" value="PMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="184"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="265"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase RgtA/B/C/D-like" evidence="9">
        <location>
            <begin position="110"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIF83791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="496" mass="56092" checksum="2E36C23A41735BE7" modified="2014-10-29" version="1">MFLLSITISKKKYSLIIFIPIILSSFTHLWNATGFPDIFYDEGIYMRRAMNVLVYQMPQENPYYYDHPLFGQMFLAGLLAVTGFPDSLHPSASVQSVEELYLVPKIWMGLLAVLDTFLIYKIAEYKYNSRVAFLASLLFAVMPMSWLFRRILLESLLLPFLLSSILFALQLARSSQKQYLPALLSGVCLGLAIFTKIPVFAMIPLVGFMIYTGSSKDRKSRLRNIGIWLIPVILIPLLWPLQSISTNSFDNWVKGVLAQTQRHSYGVAGIFETFLTVDPVLLALGVVGLMYAIPRKDLFILLWLGPFLAFLWLIGYVQYFHILPVLPVFCIAGALWLNDLVDKIKSRKHNLAGYGIVASVVLFGLVSTTLLITTNVTSAQFEATAFALSIADKDTTIIANPVYAWPYKFVFHMPYAMNDYRDVLYSEINTDKVVLVSEPHLQGSIGEPQIRQAYDSTASVRTFYGNSRNYDVGLYPYTSMALNNQGDFIDVRQRVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQJ3</accession>
    <name>A0A075MQJ3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-CoA hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_01740</name>
    </gene>
    <organism evidence="4 5">
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        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987243.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQJ3"/>
    <dbReference type="STRING" id="1459636.NTE_01740"/>
    <dbReference type="GeneID" id="41597510"/>
    <dbReference type="KEGG" id="nev:NTE_01740"/>
    <dbReference type="eggNOG" id="arCOG00773">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050164_3_2_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052816">
        <property type="term" value="F:long-chain fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03442">
        <property type="entry name" value="BFIT_BACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040170">
        <property type="entry name" value="Cytosol_ACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033120">
        <property type="entry name" value="HOTDOG_ACOT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11049">
        <property type="entry name" value="ACYL COENZYME A THIOESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11049:SF24">
        <property type="entry name" value="CYTOSOLIC ACYL COENZYME A THIOESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51770">
        <property type="entry name" value="HOTDOG_ACOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HotDog ACOT-type" evidence="3">
        <location>
            <begin position="9"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF83801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="159" mass="17380" checksum="6A5D417EE1A867EB" modified="2014-10-29" version="1">MSLNAKSPQDSQAETTVLMMPSDANPMGNVFGGVILKHVDLIAGIVAKRHVGHPNVVTAAMDRMTFLKPVFIGNALVLSARINYVRRSSMEVEVTVESEDYDSGTKARTGTAFVTLVALDKHGKATEVPPLLLETAEDKKRFSEGEKRMQQRLREAGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQN7</accession>
    <name>A0A075MQN7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein L18E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_01337</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700181.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQN7"/>
    <dbReference type="STRING" id="1459636.NTE_01337"/>
    <dbReference type="GeneID" id="41597136"/>
    <dbReference type="KEGG" id="nev:NTE_01337"/>
    <dbReference type="eggNOG" id="arCOG00780">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_146465_0_0_2"/>
    <dbReference type="OrthoDB" id="11309at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000039">
        <property type="entry name" value="Ribosomal_eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001196">
        <property type="entry name" value="Ribosomal_uL15_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003079">
        <property type="entry name" value="PRK04005.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10934">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10934:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17135">
        <property type="entry name" value="Ribosomal_L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00475">
        <property type="entry name" value="RIBOSOMAL_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="4">
        <location>
            <begin position="23"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF83405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="116" mass="12389" checksum="12CA6699B5ADADD1" modified="2014-10-29" version="1">MFANTLVDNTVWTLRKAAKKNKAPIWKDLESRVSGPRSNRSEVNLGKLAQVTKASEVIVVPGKVLGTGNLGHKLTVCAFSISESAAKKIGDMGGKVVSLDDLIKKYPDGKGVRIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQQ5</accession>
    <name>A0A075MQQ5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sulfurtransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_01352</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700194.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQQ5"/>
    <dbReference type="STRING" id="1459636.NTE_01352"/>
    <dbReference type="GeneID" id="41597150"/>
    <dbReference type="KEGG" id="nev:NTE_01352"/>
    <dbReference type="eggNOG" id="arCOG02019">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031618_1_3_2"/>
    <dbReference type="OrthoDB" id="10492at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01448">
        <property type="entry name" value="TST_Repeat_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01449">
        <property type="entry name" value="TST_Repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051126">
        <property type="entry name" value="Thiosulfate_sulfurtransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001307">
        <property type="entry name" value="Thiosulphate_STrfase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43855">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43855:SF1">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00380">
        <property type="entry name" value="RHODANESE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00683">
        <property type="entry name" value="RHODANESE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="3">
        <location>
            <begin position="21"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="3">
        <location>
            <begin position="161"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF83420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="283" mass="32394" checksum="3AF7BA8575AB2794" modified="2014-10-29" version="1">MASYSHPEVLTETDWVASNLNNKNIKILEVDYDPENAYRQGHVPGAHLVWWKRDINDPVRRDIISKQQFEALMSKVGATSDTELVLYGDFNNWFAAFAFWVFQYYGHKKIKIMNGGRKKWELEKREYAKDEPSVTPSKYVANPADEGVRAFMPDVRRALERAQEIVLVDVRSPKEFTGEITAPPEYPMEHAQRGGHIPGAKNIPWAQAVKDADGTFKSAEELKALYEGKGVTPDKEVVCYCRIGERSSHSWFVLKYLLGYPSVRNYDGSWTEWGNMIGNPIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQX9</accession>
    <name>A0A075MQX9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD(P)H-hydrate epimerase</fullName>
            <ecNumber evidence="1">5.1.99.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">NAD(P)HX epimerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nnrE</name>
        <name evidence="3" type="ORF">NTE_01555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6R)-NADHX = (6S)-NADHX</text>
            <dbReference type="Rhea" id="RHEA:32215"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:64075"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6R)-NADPHX = (6S)-NADPHX</text>
            <dbReference type="Rhea" id="RHEA:32227"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:64077"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="1">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NnrE/AIBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.1.99.6" evidence="1"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700357.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQX9"/>
    <dbReference type="STRING" id="1459636.NTE_01555"/>
    <dbReference type="GeneID" id="41597337"/>
    <dbReference type="KEGG" id="nev:NTE_01555"/>
    <dbReference type="eggNOG" id="arCOG00018">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024853_0_1_2"/>
    <dbReference type="OrthoDB" id="15148at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052856">
        <property type="term" value="F:NAD(P)HX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031087">
        <property type="term" value="P:deadenylation-independent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10260">
        <property type="entry name" value="YjeF N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01966">
        <property type="entry name" value="NADHX_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004443">
        <property type="entry name" value="YjeF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036652">
        <property type="entry name" value="YjeF_N_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00197">
        <property type="entry name" value="yjeF_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13612">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13612:SF0">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03853">
        <property type="entry name" value="YjeF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64153">
        <property type="entry name" value="YjeF N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51385">
        <property type="entry name" value="YJEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0630">Potassium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjeF N-terminal" evidence="2">
        <location>
            <begin position="22"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="74"/>
            <end position="78"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="150"/>
            <end position="156"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF83618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="242" mass="26025" checksum="1A55C4360EAAC9FE" modified="2014-10-29" version="1">MKKKGRATTKTTAATAITSDQMYSIEENGHSEIGMRRFLMMENAGHGISDFIAGKFKNYNLKNKKIVAVCGTGNNGGDGLVAVRHLAGYGAKASVVLLGSPSDIKSEEARLNWGIVEKMDSVEIIFGKEVSDAVRKKIMSADIILDGIFGTGIKREIKEPHASAIDAINNSKKQAYVLAIDIPSGLDPNTGSVYNDKAVRADATITFHRMKKGLVAKGARKYTGPVYVEQIGIPPEAERGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MR85</accession>
    <name>A0A075MR85_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Periplasmic immunogenic protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01542</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700346.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MR85"/>
    <dbReference type="STRING" id="1459636.NTE_01542"/>
    <dbReference type="GeneID" id="41597326"/>
    <dbReference type="KEGG" id="nev:NTE_01542"/>
    <dbReference type="eggNOG" id="arCOG04715">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080344_1_0_2"/>
    <dbReference type="OrthoDB" id="12132at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.170">
        <property type="entry name" value="Protein of unknown function (DUF541), domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2970">
        <property type="entry name" value="Protein of unknown function (DUF541), domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052022">
        <property type="entry name" value="26kDa_periplasmic_antigen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007497">
        <property type="entry name" value="SIMPL/DUF541"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34387">
        <property type="entry name" value="SLR1258 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34387:SF2">
        <property type="entry name" value="SLR1258 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04402">
        <property type="entry name" value="SIMPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="276" mass="28784" checksum="1750230E1F12AEBF" modified="2014-10-29" version="1">MSYQNMKNNRNLVLIAGILAIGLVAASILGGQSMTTAAAQQQPTQNNGNGNNNNSKPTVSTTGTASTNVTPDKVSVTIGVETNSTTAAEAAAANAKLMQKVIDALKALGITDSQIATSYYSIFPVYDTVSPVCIEIYPQPPECKPKSEITGYRAVNSVTVTVDASSDVGKIIDTAVGAGANNVNGAYFFISDAKQQEIRDSLIEKAIDNARNRADKAASAVDTNVTGVQSISLNDIYFPVIYKDFANAAVGGAPTTPIVPGQQQVTLNVQVVFTMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRL9</accession>
    <name>A0A075MRL9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01747</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700510.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRL9"/>
    <dbReference type="GeneID" id="41597517"/>
    <dbReference type="KEGG" id="nev:NTE_01747"/>
    <dbReference type="HOGENOM" id="CLU_126369_0_0_2"/>
    <dbReference type="OrthoDB" id="6536at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043200">
        <property type="term" value="P:response to amino acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30154">
        <property type="entry name" value="LEUCINE-RESPONSIVE REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30154:SF34">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR AZLB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13412">
        <property type="entry name" value="HTH_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="161" mass="18324" checksum="9080D0F273424C52" modified="2014-10-29" version="1">MRKNNVDVPHIDEFDARLLSLLTSQESYSSKDLAAKLDKPLSTVQRRIRILFQNGYIKKKYEVDYLKLGCRKGILDICLKDSDIECVAKKVSRISGVILVSVPLGHSDLSASFVYKTNDEVLRFIRQVKKMPEVQRVTWTEEVFSLSAARPVLIEYLCSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRT1</accession>
    <name>A0A075MRT1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01812</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700568.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRT1"/>
    <dbReference type="STRING" id="1459636.NTE_01812"/>
    <dbReference type="GeneID" id="41597577"/>
    <dbReference type="KEGG" id="nev:NTE_01812"/>
    <dbReference type="eggNOG" id="arCOG08709">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_151093_0_0_2"/>
    <dbReference type="OrthoDB" id="8758at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="140" mass="14108" checksum="3C4D4BF4AAEE4F08" modified="2014-10-29" version="1">MAKVKIAIGLLVASLVLLVIYGADAAVAGSSPNHRGFLPFDESVRGSGFGGGAVIMSIIAFVIARKEPSKAVMALLFVNGGLIIAGMLALIAQGALASENSSGAMRTIGSTIGMGAILVGLGVWKAASDRRIASKPQASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MS27</accession>
    <name>A0A075MS27_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF5679 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_01909</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MS27"/>
    <dbReference type="KEGG" id="nev:NTE_01909"/>
    <dbReference type="HOGENOM" id="CLU_200165_0_0_2"/>
    <dbReference type="OrthoDB" id="30510at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044044">
        <property type="entry name" value="DUF5679"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18930">
        <property type="entry name" value="DUF5679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5679" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF83968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="58" mass="5852" checksum="0C577C825965D9EC" modified="2014-10-29" version="1">MKGEKQVTMKNGRNALSGTCSVCGTKMFKIGGGGGGAKAKAKAPAKKAAKKKAGKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MS44</accession>
    <name>A0A075MS44_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATPase, PilT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NTE_02293</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the PINc/VapC protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MS44"/>
    <dbReference type="STRING" id="1459636.NTE_02293"/>
    <dbReference type="KEGG" id="nev:NTE_02293"/>
    <dbReference type="eggNOG" id="arCOG04116">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023387_0_0_2"/>
    <dbReference type="OrthoDB" id="7146at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00105">
        <property type="entry name" value="KH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09878">
        <property type="entry name" value="PIN_VapC_VirB11L-ATPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052041">
        <property type="entry name" value="Nucleic_acid_metab_PIN/TRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010335">
        <property type="entry name" value="PRK13764.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11603">
        <property type="entry name" value="AAA FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11603:SF147">
        <property type="entry name" value="MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PIN" evidence="5">
        <location>
            <begin position="25"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="283"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="508"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00046345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF84346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="629" mass="69098" checksum="BD646628A8AE17C9" modified="2014-10-29" version="1">MYNFYDNKSLSTVFLNPQSGENHVAKFVLDTSIIIDGEITKMLEAGDIEDKSEIIIPLAVLDELQAQASTNKEHGFVGLAEIKKMRELASARDITVRFSGARPDINDIRLAKHGRIDAIIKDVAMNESATLLTADYVQALVAEAQGIKSRHIRAPTKTADLAFEKFFDESTMSVHLKENVVPMAKRGKPGNFQLVQVGSAKSTYGQLNEMVKEISEASRVSGTGTVEISRSGATVIQFGLYRIAITRPPFSDGFEVTIVRPTVRLALADYHASEKLMERLSGKAEGIIIAGPPGSGKSTLASSLAEFYAQKGKIVKTFESPRDLQVPEEVTQYGPLEGSFEKAVDILLLVRPDYTIYDEVRRAQDFQVFADMRLAGVGMVGVVHASSPLDAVQRFMGKVELGMIPHILDTIIFVKEGRIDKVYELSLTVKVPSGMTEADLARPLVEVRDFESGAVEYEIYTYGEENVVVPVSKARGGSDESGIKKLAQSKIMDVVRRFDPRAEVNILSENRVQVKVSKDAAPKIIGRGGSTINELEEELGVHIDVEVKTPTLGKEVPFEVSESGSAITLLVDEEVIGRSVDLYIDDEYIMSSQVGKKARVKIDKRSEAGKQVFNAVVSGQEMRMFLSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MS63</accession>
    <name>A0A075MS63_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4430 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700661.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MS63"/>
    <dbReference type="STRING" id="1459636.NTE_01945"/>
    <dbReference type="GeneID" id="41597693"/>
    <dbReference type="KEGG" id="nev:NTE_01945"/>
    <dbReference type="eggNOG" id="arCOG08673">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1682754_0_0_2"/>
    <dbReference type="OrthoDB" id="5755at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="158" mass="17440" checksum="DF9D0850F0A2813F" modified="2014-10-29" version="1">MGFGGQEPGKKRRLVWSMALLAGAVIVAGAGTKAVTDYLRSQDPIYQCIQNPLAEPYQLTLPVSVTVDGAPARVPSEVGITKNCTLPVHTLQDNTIHVAYKEPYTFTLGHFLYNWIGQNLTKYDTKVYVNNVQHTGGSFLDIPLKDGDSIRIEFTTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MS72</accession>
    <name>A0A075MS72_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">anthranilate synthase</fullName>
            <ecNumber evidence="2">4.1.3.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NTE_01906</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21732"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="4.1.3.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.27" evidence="2"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700633.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MS72"/>
    <dbReference type="STRING" id="1459636.NTE_01906"/>
    <dbReference type="GeneID" id="41597656"/>
    <dbReference type="KEGG" id="nev:NTE_01906"/>
    <dbReference type="eggNOG" id="arCOG00086">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014340_1_3_2"/>
    <dbReference type="OrthoDB" id="3321at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000003">
        <property type="entry name" value="Anthranilate synthase component II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050472">
        <property type="entry name" value="Anth_synth/Amidotransfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00566">
        <property type="entry name" value="trpG_papA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43418:SF4">
        <property type="entry name" value="MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43418">
        <property type="entry name" value="MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00099">
        <property type="entry name" value="CPSGATASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="7">
        <location>
            <begin position="9"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF83965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="202" mass="22295" checksum="7E09274A8083CC23" modified="2014-10-29" version="1">MAGKKKKILVIDNYDSFVYNIAQLLGEMDTEPVVIRNDKITLAQIKKMKPDGIVISPGPGHPADKKYFGVCTDVIQQLGHKTPILGVCLGHQGIVHAFGGKVINAKKVRHGKTSTIEYGDSSDRLFGEVSNPFRATRYHSLVADKETIPDCLEVTARAKDDGEIMGIRHKQYPIEGVQFHPESILTGEGRKILSNFLSLVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MS98</accession>
    <name>A0A075MS98_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01931</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700652.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MS98"/>
    <dbReference type="STRING" id="1459636.NTE_01931"/>
    <dbReference type="GeneID" id="41597680"/>
    <dbReference type="KEGG" id="nev:NTE_01931"/>
    <dbReference type="eggNOG" id="arCOG03182">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083287_1_1_2"/>
    <dbReference type="OrthoDB" id="10712at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039422">
        <property type="entry name" value="MarR/SlyA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33164">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR, MARR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33164:SF106">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="3"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="155" mass="18005" checksum="18EEBD239FD491AC" modified="2014-10-29" version="1">MEREEVIHAVSEKFTEMSTETILFHQALADMLDLHVTDHRCMHFLHSYGAMPAGRLAELTGLTTAAVTGIIDRLEEAGYARRISDPKDRRRTIVEPVQNKKLERKLEAIFTPFHEKMHELLSPYSDSELTFLLDVMNKSIELTREESKKLRHMQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSF3</accession>
    <name>A0A075MSF3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01992</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700700.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSF3"/>
    <dbReference type="STRING" id="1459636.NTE_01992"/>
    <dbReference type="GeneID" id="41597739"/>
    <dbReference type="KEGG" id="nev:NTE_01992"/>
    <dbReference type="eggNOG" id="arCOG10549">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1943958_0_0_2"/>
    <dbReference type="OrthoDB" id="10951at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="123" mass="13014" checksum="DBB17E73777FB564" modified="2014-10-29" version="1">MRIAFVVAIAGGIIVAAVVAMYASQLPTQDYSLSVDALKDEQSIFTNARVVLSNTGRMPLTNVMVNYGGNSTEFVGTMAPGHKTTVSPPEGTQLTFVTVTADHDIKIVQAYRAPIKLPGMIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSH0</accession>
    <name>A0A075MSH0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385317.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSH0"/>
    <dbReference type="STRING" id="1459636.NTE_02013"/>
    <dbReference type="GeneID" id="43502631"/>
    <dbReference type="KEGG" id="nev:NTE_02013"/>
    <dbReference type="HOGENOM" id="CLU_217066_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="46" mass="5141" checksum="AE0A367B3DCE5D1F" modified="2014-10-29" version="1">MAIRYRCVNCNIVLSGEGASRHYLANPTHKLEKLPPPPKPVKSPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSL8</accession>
    <name>A0A075MSL8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02522</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385484.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSL8"/>
    <dbReference type="GeneID" id="43502649"/>
    <dbReference type="KEGG" id="nev:NTE_02522"/>
    <dbReference type="HOGENOM" id="CLU_3003274_0_0_2"/>
    <dbReference type="OrthoDB" id="373735at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="57" mass="6407" checksum="8043763C7BFADADE" modified="2014-10-29" version="1">MAATDLKRAPSEKKEVVKNLYVSGIPEEFIAMQLDIEIPVVIAILKEQGIYRHANEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSP0</accession>
    <name>A0A075MSP0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cob(I)yrinic acid a,c-diamide adenosyltransferase</fullName>
            <ecNumber evidence="1">2.5.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01736</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.5.1.17" evidence="1"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700500.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSP0"/>
    <dbReference type="STRING" id="1459636.NTE_01736"/>
    <dbReference type="GeneID" id="41597506"/>
    <dbReference type="KEGG" id="nev:NTE_01736"/>
    <dbReference type="eggNOG" id="arCOG04678">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088595_0_0_2"/>
    <dbReference type="OrthoDB" id="24392at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008817">
        <property type="term" value="F:corrinoid adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00561">
        <property type="entry name" value="CobA_ACA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CblAdoTrfase_CobA"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00708">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PRK05986.1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CORRINOID ADENOSYLTRANSFERASE"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF02572">
        <property type="entry name" value="CobA_CobO_BtuR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015617">
        <property type="entry name" value="Adensltrnsf_CobA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="182" mass="19753" checksum="00AD072F74C12232" modified="2014-10-29" version="1">MPPPPSLDRAPVIVYTGKGKGKTTAALGIVLRAVGHGHKVGMIQFIKGEWYYGELTSSKRLEPEFEMIAAGKGFVGIIDDDHPIEEHQKASQDAVGLVRDKLASGAYDVMILDEVNYAVKLGLITVDDVLGIIAAKPDKTTLVLTGNHAHEKVLEAADLVTEMREVKHPFQKGIKARKGIDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSP4</accession>
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        <recommendedName>
            <fullName evidence="3">Deazaflavin-dependent oxidoreductase, nitroreductase family</fullName>
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        <name evidence="1" type="ORF">NTE_02118</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700796.1">
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    </dbReference>
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    <dbReference type="STRING" id="1459636.NTE_02118"/>
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    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016888">
        <property type="entry name" value="UCP028498"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10012">
        <property type="entry name" value="DUF2255"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="120" mass="13462" checksum="3588D05039DE6D0B" modified="2014-10-29" version="1">MVKEEADLRQKLNIASEITLSVKGRKSGRDISRPVWFVHEGSTLYLLPVQGSNTNWYKNFQADPTLKISVNNGSETTVKGKPITDSSRVDDVVKKFKSKYGEGDVKKYYPKTDVAVEVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MST6</accession>
    <name>A0A075MST6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01786</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700545.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MST6"/>
    <dbReference type="STRING" id="1459636.NTE_01786"/>
    <dbReference type="GeneID" id="41597552"/>
    <dbReference type="KEGG" id="nev:NTE_01786"/>
    <dbReference type="eggNOG" id="arCOG08697">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_175245_0_0_2"/>
    <dbReference type="OrthoDB" id="7369at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="87" mass="10200" checksum="8D9AD8DF0D5FF1A2" modified="2014-10-29" version="1">MIKEKIKVNNRSYDISLNEQTQMYAMKLRRLYQQSYSDMDSFDEVSSEISSTISNLLKHAASPEVREDDMDGVIQQILKMYEKSVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MST8</accession>
    <name>A0A075MST8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699397.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MST8"/>
    <dbReference type="GeneID" id="41596229"/>
    <dbReference type="KEGG" id="nev:NTE_00332"/>
    <dbReference type="HOGENOM" id="CLU_1269866_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="200" mass="22916" checksum="601AE30D2F6062F7" modified="2014-10-29" version="1">MSSLAHKRAAMLFLTVLGAAAIASVAVAPTAAHASKGDEYSYKNCGYWKETEKNYDYEYKFKKSQDYKEHEKESGEGKSYEYDYGNDDKNNGKNGDDNDDNHNGSYDNHNGDDNGKDHDKDKSSYDYGSGSGSKDSSDYDKYKREHKDSYEFEKKNTEERHDGDSWCDTDEDNDDDHDNYSKDDHHDDDDDNGDDEEDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSU4</accession>
    <name>A0A075MSU4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00342</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699406.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSU4"/>
    <dbReference type="STRING" id="1459636.NTE_00342"/>
    <dbReference type="GeneID" id="41596238"/>
    <dbReference type="KEGG" id="nev:NTE_00342"/>
    <dbReference type="HOGENOM" id="CLU_1118190_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="248" mass="29533" checksum="F7C09AD027FBF32C" modified="2014-10-29" version="1">MNNKMSSIAGNKKVFVIFSVLALSIALASSTIVSPTAAFASSSYGEEDDHHHHKKYTKDDVRKWLEDHEDECSDNHIYRWIANHFYKWEDDHKSKWIVKHFQWVVDNVDCSDDEDHDYNYYGEDDHKYYGDKDYKYYGDDDDEEGHKYYRDNSEDHKSYDDHKDYNKYNSNDDDNNGKDHEYSKDGNNEDHKSYDDDHKDYIKYNNYEEGNDKDHKDYKKYEDDNNKNGKEHNIEVALNLPLVSVAVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSZ4</accession>
    <name>A0A075MSZ4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator, AsnC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_01852</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700598.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSZ4"/>
    <dbReference type="STRING" id="1459636.NTE_01852"/>
    <dbReference type="GeneID" id="41597616"/>
    <dbReference type="KEGG" id="nev:NTE_01852"/>
    <dbReference type="eggNOG" id="arCOG01580">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091233_5_4_2"/>
    <dbReference type="OrthoDB" id="6995at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050684">
        <property type="entry name" value="HTH-Siroheme_Decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43413:SF4">
        <property type="entry name" value="HTH-TYPE TRANSCRIPTIONAL REGULATOR LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43413">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR, ASNC FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="8"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF83912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="150" mass="16204" checksum="8E8F9A228840DBEE" modified="2014-10-29" version="1">MRPAAYKIDELDVRLVEILQKDSSTPAVKIAGMLKVTEGTVRNRINRLRRQGVIRRFTVSIDPMALGQGAIAFVLLNAAPGRTAEVAKRLALIDVVAEVHETHTYGDLLLKVRAKSPSDLADIIASRIKAVPGVAGTQVITVLNAWKDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MT38</accession>
    <name>A0A075MT38_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HFX-2341-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02673</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701236.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MT38"/>
    <dbReference type="STRING" id="1459636.NTE_02673"/>
    <dbReference type="GeneID" id="41598363"/>
    <dbReference type="KEGG" id="nev:NTE_02673"/>
    <dbReference type="eggNOG" id="arCOG01449">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1212631_0_0_2"/>
    <dbReference type="OrthoDB" id="10841at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10770">
        <property type="entry name" value="Hypothetical protein VC1899 like domain (Restriction endonuclease-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046260">
        <property type="entry name" value="HFX_2341-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19810">
        <property type="entry name" value="HFX_2341_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HFX-2341-like N-terminal" evidence="1">
        <location>
            <begin position="10"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="232" mass="24871" checksum="A7FA8432FEA54966" modified="2014-10-29" version="1">MSQQQMTTLQIATFGSEGQEGIAAGIRNFPVHQLVLLCYNSDRQKAEEFARKLRTVLGLTVTLSLVTRENVIRDTMERVGEILNNISQKEFQQVLVNVSCGDKLMGCAALSAAFINGIKAFGMDSAGAPLLMPVLKLSYSEIISEAKIRILKAIHGAGGAIESLDQLEQVSGYGKPLLSYHVMGSRESKGLADLGLLEVEKGDRGKISAKLTTLGKLLVTSSAISSTPTTTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTD1</accession>
    <name>A0A075MTD1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphoribosylformylglycinamidine synthase subunit PurL</fullName>
            <shortName evidence="8">FGAM synthase</shortName>
            <ecNumber evidence="8">6.3.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Formylglycinamide ribonucleotide amidotransferase subunit II</fullName>
            <shortName evidence="8">FGAR amidotransferase II</shortName>
            <shortName evidence="8">FGAR-AT II</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Glutamine amidotransferase PurL</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Phosphoribosylformylglycinamidine synthase subunit II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">purL</name>
        <name evidence="12" type="ORF">NTE_01994</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + L-glutamine + ATP + H2O = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + L-glutamate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17129"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the FGAMS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.3" evidence="8"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTD1"/>
    <dbReference type="STRING" id="1459636.NTE_01994"/>
    <dbReference type="KEGG" id="nev:NTE_01994"/>
    <dbReference type="eggNOG" id="arCOG00641">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003100_0_1_2"/>
    <dbReference type="OrthoDB" id="8251at2157"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02203">
        <property type="entry name" value="PurL_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02204">
        <property type="entry name" value="PurL_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="entry name" value="PurM-like C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="entry name" value="PurM-like, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00420">
        <property type="entry name" value="PurL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010074">
        <property type="entry name" value="PRibForGlyAmidine_synth_PurL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041609">
        <property type="entry name" value="PurL_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01736">
        <property type="entry name" value="FGAM_synth_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002290">
        <property type="entry name" value="PRK01213.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43555">
        <property type="entry name" value="PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE SUBUNIT PURL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43555:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE SUBUNIT PURL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18072">
        <property type="entry name" value="FGAR-AT_linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001587">
        <property type="entry name" value="FGAM_synthase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="PurM C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="PurM N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 8 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoribosylformylglycinamidine synthase linker" evidence="11">
        <location>
            <begin position="4"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="PurM-like N-terminal" evidence="9">
        <location>
            <begin position="61"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="PurM-like C-terminal" evidence="10">
        <location>
            <begin position="195"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="PurM-like N-terminal" evidence="9">
        <location>
            <begin position="429"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="PurM-like C-terminal" evidence="10">
        <location>
            <begin position="559"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="35"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="80"/>
            <end position="83"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="303"/>
            <end position="305"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="484"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="521"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="524"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIF84052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="727" mass="77851" checksum="89217B1FA2918B2F" modified="2014-10-29" version="1">MGVLTEQELAYLEGKLKRKANEVEQDIVGAEWSEHCSYKSSKKFLRLLPTRGKRVLVGPGYDAGVLDVGDGYVLTVHIESHNHPSAVEPFGGAATGVGGVIRDIMSMGTRPIAVLDALRFAPIDCSNGKKSATTAKSKWLFKNVVKGIADYGNCIGIPTVGGEIEFDQSFEDYCLVDVASIGHGKKEDVISNRAEVGDYIVLAGGSTGRDGIHGASFASRALEAENRSAVQIPDPFLEKLLLEATMEAVQQGCVKAIKDLGGGGLSCCLSETSDNLGRGFKVELSKVNAREVGMTPAELMISESQERMLYVTDAQKLPKLQSILDKYEIRYSVLGKAEGHQDLVITYNDSVVANMPSSLVAHAPPADRAASRPAYLDRLKKVRTPKMPANLGKTLLALLSNPTIASKRWVYQQYDHEVGVRTVAKPGAADAAVMRLDNGKFAAVKLDGNSKHCYLDPYQGTLGCLSEGCRNVICTGAEPAGVVDHLQFGSPEDPEIFWTFSQAVSAIVDYCNFMEIPVVGGKVSFYNETAKGPIKPSPVMGTLGLIDDEKWITKSALGTGQSIFVVGQTRPEMGGSEYYEYVHGITGGQLPTVDLATDRTNGSAVLKLIRSGLASCAHDCSKGGIAVALAEMAVAGNTGFRVQLDSVPSTCTRLDDLLFSESHSRYLVGTTKPEQVARLLQSEGVKFAQIGKSVRGKAEFVQGKRAKISLPLSKLQGAFDSLGKIMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTG3</accession>
    <name>A0A075MTG3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ca2+/Na+ antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NTE_02020</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700723.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTG3"/>
    <dbReference type="STRING" id="1459636.NTE_02020"/>
    <dbReference type="GeneID" id="41597764"/>
    <dbReference type="KEGG" id="nev:NTE_02020"/>
    <dbReference type="eggNOG" id="arCOG02881">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077877_0_0_2"/>
    <dbReference type="OrthoDB" id="10957at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF36">
        <property type="entry name" value="SODIUM_CALCIUM EXCHANGER MEMBRANE REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="8">
        <location>
            <begin position="9"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="8">
        <location>
            <begin position="189"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF84077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="347" mass="36765" checksum="51C012DCED9F22C2" modified="2014-10-29" version="1">MAEENNLLMMLLWLGELTLASWVLSYGAEHLSMRYGAKFVGRTLLSVATTLPEIAIVVYAAAAGSYGTAIGAGLGSNLLMMTLGLAIMLIVATTRLSKAPLKGIDVSTFKLDKIFLLITAVVSAALFLDGYDYIDGFVFAGMFAAYLVMALWEMKNEKKKAKNEVKSAGSHEVVAVETHTVSGRQMTKAALAFAAGTAGIFIGAEPFIHSLQGFSLDSGVSVIVLAVIISPIAGEMPEKISMILLARKGAAGASIAVANVLGSKILNNTLLLAVAVFGAMYHGGFFAHIDANPLLEYQMILVTVMTIGAVAMMFKKEIGLKIGIILAVLYAVSLVIQFLLPQDLTLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTJ0</accession>
    <name>A0A075MTJ0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Universal stress protein UspA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_00528</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385010.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTJ0"/>
    <dbReference type="STRING" id="1459636.NTE_00528"/>
    <dbReference type="GeneID" id="41596400"/>
    <dbReference type="KEGG" id="nev:NTE_00528"/>
    <dbReference type="eggNOG" id="arCOG02053">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049301_11_1_2"/>
    <dbReference type="OrthoDB" id="105697at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00293">
        <property type="entry name" value="USP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46268">
        <property type="entry name" value="STRESS RESPONSE PROTEIN NHAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46268:SF6">
        <property type="entry name" value="UNIVERSAL STRESS PROTEIN UP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UspA" evidence="2">
        <location>
            <begin position="5"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF82609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="147" mass="16227" checksum="2BC6DD81C299301C" modified="2014-10-29" version="1">MTKEFEKILVAVDGSDQSMRAVDIAISLAKKYESALTALYVIHIPFGESLYPRSAWHKDFIDDINKDTGGWFAEIQRRGKENGVEISSEMKETAESVPAEITRYAKEDKIDLIVVGSKGKSELEKMFLGSVAAGVLAYAPCPVLVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTP6</accession>
    <name>A0A075MTP6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02956</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701466.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTP6"/>
    <dbReference type="GeneID" id="41598628"/>
    <dbReference type="KEGG" id="nev:NTE_02956"/>
    <dbReference type="HOGENOM" id="CLU_173770_0_0_2"/>
    <dbReference type="OrthoDB" id="8243at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="109" mass="12788" checksum="AB90BCFA86FA75B5" modified="2014-10-29" version="1">MTDITNFVDWNELKGKEARGVTKDVDLGEVQEIGRHYIVTQKGRVDQDKFYIPKYLAERYDGHILYFNVSEGQKIEFKRQNPPTYEEYARYRVAGLPADIETRVRVTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTQ3</accession>
    <name>A0A075MTQ3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative membrane protein/domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NTE_02516</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701118.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTQ3"/>
    <dbReference type="STRING" id="1459636.NTE_02516"/>
    <dbReference type="GeneID" id="41598220"/>
    <dbReference type="KEGG" id="nev:NTE_02516"/>
    <dbReference type="eggNOG" id="arCOG03633">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104051_0_0_2"/>
    <dbReference type="OrthoDB" id="288430at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051791">
        <property type="entry name" value="Pra-immunoreactive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010432">
        <property type="entry name" value="RDD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36115">
        <property type="entry name" value="PROLINE-RICH ANTIGEN HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06271">
        <property type="entry name" value="RDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="RDD" evidence="7">
        <location>
            <begin position="19"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF84565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="168" mass="19019" checksum="4DC0E9FD39D918B4" modified="2014-10-29" version="1">MSSETPAPSSGSQPELVLARWSDRFFAWLIDFVMVQVALYAIFAAAAFPFWFDDFSRADRFWGDGPVRYVITSVVFFAYWTFFESTKGQSLGKMVLKIRTVDLAGRPVDTRSAAIQSFGKAFLLPIDVVLGWIFTNDKRQRLFNRASDTIVIKETAASTQPSTSYRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTS9</accession>
    <name>A0A075MTS9_9ARCH</name>
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        <submittedName>
            <fullName evidence="4">Cytochrome c biogenesis factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_02991</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85026.1"/>
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    <dbReference type="GeneID" id="41598661"/>
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        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_810386_0_0_2"/>
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    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051685">
        <property type="entry name" value="Ycf3/AcsC/BcsC/TPR_MFPF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44943">
        <property type="entry name" value="CELLULOSE SYNTHASE OPERON PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44943:SF8">
        <property type="entry name" value="TPR REPEAT-CONTAINING PROTEIN MJ0263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48439">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="158"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF85026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="342" mass="39386" checksum="90A71B4C366A96A4" modified="2014-10-29" version="1">MGQSGSNSDLKVESVQKLLDEAEKFSKAGMLLDAKKRYDEILASDPENVVANQQKGIILYLYKKYELAYKLLKKALDREENVLTLLYLGKTLNGLERYVEAIGYFDAILLKHDPNDVEALYGKGYALNRKNVTGNYDGRFDNAIECFETLLKLDPRNTFALVEEARAYERLQKYDKALRCYEKIVEYEPDNILAISGIGFLSLHNLGEDERIYKRALDCFEKALVMQPNDPYFIDYKMQALVKLGRYKEALGCHDAIAQLYSNSVPNNPSAVLIHILKGHTEYQKARISCDDRRIPEAYYRLNQAMRYNSDFGKMAAHDERFRPAWGDHNFQKVVREGPLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTV5</accession>
    <name>A0A075MTV5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PilT domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTV5"/>
    <dbReference type="STRING" id="1459636.NTE_03036"/>
    <dbReference type="KEGG" id="nev:NTE_03036"/>
    <dbReference type="eggNOG" id="arCOG04312">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd09879">
        <property type="entry name" value="PIN_VapC_AF0591-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041120">
        <property type="entry name" value="PIN_9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18477">
        <property type="entry name" value="PIN_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VapC9 PIN-like" evidence="1">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="129" mass="14540" checksum="74C1039BCF749529" modified="2014-10-29" version="1">MQVLCDTSFLMVLVEKPIKYIDRIEHEFGRLDFIVPEIVVGELRRLAEKAGPKRAMMAKTALEVINAKFRQVQIPKAAHVDDAIVEYATENKCAVATIDTNLRRRLIANEVLVLTLSRDRLVVANPNLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTW7</accession>
    <name>A0A075MTW7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03056</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701555.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTW7"/>
    <dbReference type="STRING" id="1459636.NTE_03056"/>
    <dbReference type="GeneID" id="41598724"/>
    <dbReference type="KEGG" id="nev:NTE_03056"/>
    <dbReference type="HOGENOM" id="CLU_377508_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="734" mass="83943" checksum="951855EE02A91CCA" modified="2014-10-29" version="1">MSLIGIDSIVQEIEDRRLYNDDEITAFLVHKGIVNREQKIQLFKAITEDFLYDHSFMQNHIMEVFSDGDDFVDLILHLSSKNYHSSVSKLADAYKHDPVQALNLYDKILKNDSKSRSIPLAQILFGIGKNDLTKFYSMLDFSDQRPEIKTAYIEALRYLSYEVSIKKSSIDYVIEQSDSVDAGIRETAIHFMLSAGIDDIDVRNRLVELASNGQQNDKIRIGWNGLILQKRNKSLCLELVKLLSESEDIAVLKSLGITMGSVAEDYPVECLEIIRRWFNTESLRNKISTGWAPERVDAYLLKWITEEKDELILKFDLPKLIWDIFEKGDKTRLLNILYKIDVSTEGGLTVFDEVAGKALSEMHKNPQHDSTFVERCHELVCRMAIARGVDPSTIKINKDDKTLLTLAILERATADKKEIDFSAVLSNVAQYKNIERLVGRKWFEERASKKDTSQPLIWLLAKANPKEEEIKQLFEELEKYKDDQLRKWSVLMAIRLKLQPYAVLEHIDRSIAIFMKDPLPRLKAVRDSLINPDQIYQTVGELVLAAHLRAAYPAEIQFKVGKKIAGCRTIIEGKEIIIEVVNPDMSLESKYLRGVLTQAGNRTKSQIKNKLKEQIPEIAKNTDAPIFLAINRGRSGIDDMEIADTLYGSLKVRMYLDKETSKVVKSESFREADGISTDNAGRQVSGVIFYNTVFDFSDFKEKLEGDIFENDTDRPVSKDMIKKMKEVLFNKALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTX5</accession>
    <name>A0A075MTX5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 14">Mevalonate kinase</fullName>
            <shortName evidence="14">MK</shortName>
            <shortName evidence="14">MVK</shortName>
            <ecNumber evidence="3 14">2.7.1.36</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">mvk</name>
        <name evidence="17" type="ORF">NTE_02597</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(R)-mevalonate + ATP = (R)-5-phosphomevalonate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17065"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36464"/>
            <dbReference type="ChEBI" id="CHEBI:58146"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.36"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13 14">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the GHMP kinase family. Mevalonate kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.36" evidence="3 14"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701174.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTX5"/>
    <dbReference type="STRING" id="1459636.NTE_02597"/>
    <dbReference type="GeneID" id="41598290"/>
    <dbReference type="KEGG" id="nev:NTE_02597"/>
    <dbReference type="eggNOG" id="arCOG01028">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017814_0_0_2"/>
    <dbReference type="OrthoDB" id="19001at2157"/>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00098"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004496">
        <property type="term" value="F:mevalonate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00217">
        <property type="entry name" value="Mevalonate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006205">
        <property type="entry name" value="Mev_gal_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022937">
        <property type="entry name" value="Mevalonate_kinase_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00549">
        <property type="entry name" value="mevalon_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43290">
        <property type="entry name" value="MEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43290:SF2">
        <property type="entry name" value="MEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00959">
        <property type="entry name" value="MEVGALKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12 14" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="8 14 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11 14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="15">
        <location>
            <begin position="92"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="16">
        <location>
            <begin position="237"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AIF84640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="333" mass="34945" checksum="C585FE091ABD6252" modified="2014-10-29" version="1">MTATTVTVAKARAAAPAKIILFGEHFVVYGNPAILASINRRITVTAKKSKDGKVKIKSDIASGEFDGSTFRLIEGANARATLEPLYYAAKQALDDRKQQNNNKSGLEIEIKSDIPYGVGLGSSAAALVATIAAVESLAGKADKKKVCESAIEAEKIIHKNSSGADCFVSTFGGMMHYSKGGGFKKIEAKTKIFLVIGDTGIKHNTGDLVSSVRKLKEANQMAFSGLMSQARDICNQALAALNNGNIEYLGMLMNENQLLLERLGVSHEKADDLIDVARRAGALGAKITGAGGGGAIIALAASKEDSERIASAIKEAGQSAFEVEIDTKGLVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTX8</accession>
    <name>A0A075MTX8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF308 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701566.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTX8"/>
    <dbReference type="GeneID" id="41598740"/>
    <dbReference type="KEGG" id="nev:NTE_03077"/>
    <dbReference type="HOGENOM" id="CLU_1264527_0_0_2"/>
    <dbReference type="OrthoDB" id="385029at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005325">
        <property type="entry name" value="DUF308_memb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03729">
        <property type="entry name" value="DUF308"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="218" mass="22397" checksum="0EC363FD7F7A6A53" modified="2014-10-29" version="1">MKNLSITLSFIPLIKRGVTATKITGVKSPSWVRALQIAIGAIAIVLSLAAIIYPVITIVTVFTVAAIVLLLIGIESVIAGIFLYKQARGAHIGLGILVIVLSIFMMAFPLSSAVFAIILGAVALMFSGFASIVAGLMGRNELTGDINMPRPSKGARTLSVIAGALAVALSIMILASPAFGIALAAVVIGVGLLVYGIRLVVTGITGRGQAWMPSLSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MU38</accession>
    <name>A0A075MU38_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Argininosuccinate synthase</fullName>
            <ecNumber evidence="3 9">6.3.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Citrulline--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">argG</name>
        <name evidence="13" type="ORF">NTE_00731</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-citrulline + L-aspartate + ATP = 2-(N(omega)-L-arginino)succinate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10932"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 9">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the argininosuccinate synthase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.5" evidence="3 9"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699707.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MU38"/>
    <dbReference type="STRING" id="1459636.NTE_00731"/>
    <dbReference type="GeneID" id="41596583"/>
    <dbReference type="KEGG" id="nev:NTE_00731"/>
    <dbReference type="eggNOG" id="arCOG00112">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032784_4_0_2"/>
    <dbReference type="OrthoDB" id="5877at2157"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004055">
        <property type="term" value="F:argininosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000053">
        <property type="term" value="P:argininosuccinate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000050">
        <property type="term" value="P:urea cycle"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="ASS"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Argininosuccinate synthase"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Argininosuccinate synthase"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Argininosuccinate synthetase, chain A, domain 2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Arg_succ_synth_type1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Arginosuc_syn_C"/>
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        <property type="entry name" value="Arginosuc_syn_N"/>
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    <dbReference type="InterPro" id="IPR001518">
        <property type="entry name" value="Arginosuc_synth"/>
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    <dbReference type="InterPro" id="IPR018223">
        <property type="entry name" value="Arginosuc_synth_CS"/>
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    <dbReference type="InterPro" id="IPR023434">
        <property type="entry name" value="Arginosuc_synth_type_1_subfam"/>
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        <property type="entry name" value="AS_cat/multimer_dom_body"/>
    </dbReference>
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        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00032">
        <property type="entry name" value="argG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001770">
        <property type="entry name" value="PRK00509.1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PRK13820.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587">
        <property type="entry name" value="ARGININOSUCCINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARGININOSUCCINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20979">
        <property type="entry name" value="Arginosuc_syn_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00764">
        <property type="entry name" value="Arginosuc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Argininosuccinate synthetase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00564">
        <property type="entry name" value="ARGININOSUCCIN_SYN_1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00565">
        <property type="entry name" value="ARGININOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 9" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arginosuccinate synthase-like N-terminal" evidence="11">
        <location>
            <begin position="4"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Arginosuccinate synthase C-terminal" evidence="12">
        <location>
            <begin position="172"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="394"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="8"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
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        </ligand>
    </feature>
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        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF20979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIF82809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="413" mass="46007" checksum="5D19907CDE3BEE3A" modified="2014-10-29" version="1">MANKVVLAYSGGLDTSVCIRYLQTLHKMDVITVTVDCGQDDDFAEIERRAKAIGAIKHVYVDAKDEFARDYVIPSIKANGLYQGKYPLATALARPLIAAKTVEVATKENAVAIAHGCTGKGNDQIRFDVTMRALRPDLKIIAPIRDMNLTRDVEIKYAKEQNIPISTEAKKYSIDLNLWGRAVEGGNIEDADFEPPEEAFQYINFKNDKAGYVEIEFDQGVPVAADGKHMSLTDLIQYVNDKAGAHGVGIVDHIEDRVVGIKSREVYEAPAAVTIIEAHRDLEKMVLTKHELAFKRMVDDQWSWLAYAGLWQDPLRTDLDRFIDATQTRVSGKVRVKLQRGSLRVVGRQSRYSLYKNDLATYAAGSTFDQSLAKGFVELWGLQSIIANSVAGTADKKQQQQQQEKLVGGKNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MU48</accession>
    <name>A0A075MU48_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Translation initiation factor 2 subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">aIF2-beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">eIF-2-beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NTE_03154</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-beta/eIF-5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MU48"/>
    <dbReference type="STRING" id="1459636.NTE_03154"/>
    <dbReference type="GeneID" id="41598813"/>
    <dbReference type="KEGG" id="nev:NTE_03154"/>
    <dbReference type="eggNOG" id="arCOG01640">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026663_3_1_2"/>
    <dbReference type="OrthoDB" id="38099at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.170:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045196">
        <property type="entry name" value="IF2/IF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002735">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016189">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016190">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_Zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003067">
        <property type="entry name" value="PRK03988.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001:SF3">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01873">
        <property type="entry name" value="eIF-5_eIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00653">
        <property type="entry name" value="eIF2B_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100966">
        <property type="entry name" value="Translation initiation factor 2 beta, aIF2beta, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75689">
        <property type="entry name" value="Zinc-binding domain of translation initiation factor 2 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translation initiation factor IF2/IF5" evidence="7">
        <location>
            <begin position="28"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF85186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="143" mass="16058" checksum="543C0B319FD6CFC2" modified="2014-10-29" version="1">MSVQKAADYEALLKRLQDKLGTGARKATSRLEIPQPQIIWVGKNTIFRNFMEFPKALRRDPEKLLLYLNKELASAGYIQGDRVHFLGRKSPSSFAALIDRYVKDYVLCPVCGSPDTRTEKNKKLGFLICEACGAKSSIKGNYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MU92</accession>
    <name>A0A075MU92_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700887.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MU92"/>
    <dbReference type="STRING" id="1459636.NTE_02228"/>
    <dbReference type="GeneID" id="41597948"/>
    <dbReference type="KEGG" id="nev:NTE_02228"/>
    <dbReference type="HOGENOM" id="CLU_1478963_0_0_2"/>
    <dbReference type="OrthoDB" id="383284at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="61"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="198" mass="22761" checksum="14B44B5C91E266D0" modified="2014-10-29" version="1">MSCTLDDLKTAASSEGVNLIPFSDLRKEATSIADDIARRKEEVDTKGNVLTSQKDSKLWDIKQLNEKIANEEKVEATLRRQDDIDKWKKEIEDLNGKVKDINSQLDTVLDSARRLYDLRVSLREWFDKAKRLLSDLKSNPERALGSNPSDENKKELERCANEIISRIERGESGHKTAEDQVKRQVEKLKEALDKTEYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUD4</accession>
    <name>A0A075MUD4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative DNA binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701238.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUD4"/>
    <dbReference type="STRING" id="1459636.NTE_02675"/>
    <dbReference type="GeneID" id="41598365"/>
    <dbReference type="KEGG" id="nev:NTE_02675"/>
    <dbReference type="eggNOG" id="arCOG02271">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1275264_0_0_2"/>
    <dbReference type="OrthoDB" id="165911at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007050">
        <property type="entry name" value="HTH_bacterioopsin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34236">
        <property type="entry name" value="DIMETHYL SULFOXIDE REDUCTASE TRANSCRIPTIONAL ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34236:SF1">
        <property type="entry name" value="DIMETHYL SULFOXIDE REDUCTASE TRANSCRIPTIONAL ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04967">
        <property type="entry name" value="HTH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH bat-type" evidence="1">
        <location>
            <begin position="159"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="216" mass="24658" checksum="6F375BD9C9C370E8" modified="2014-10-29" version="1">MRRVTLEFNYQDAWKQIFGSNYGKVEVLEALRCFRCDTQGLALICRIRLKDKSMDVKDLVGNGLLTNLEVLYREKDGSLVVFLEGETVVPQSPGNLYRPRLLMARPPEFLDVNRMKAELVGKETEIKKFLQYTNKLSSTYKILGLTSVDTKAESPLSKLTLKQRQTLLMAFALGYYDVPRRISSEELSRHLNADKSTVVEHLRKAERKLIDGIIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUD8</accession>
    <name>A0A075MUD8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">4-hydroxybenzoate synthetase (Chorismate lyase)</fullName>
            <ecNumber evidence="1">4.1.3.40</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02279</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.1.3.40" evidence="1"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700926.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUD8"/>
    <dbReference type="STRING" id="1459636.NTE_02279"/>
    <dbReference type="GeneID" id="41597994"/>
    <dbReference type="KEGG" id="nev:NTE_02279"/>
    <dbReference type="eggNOG" id="arCOG01031">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1529281_0_0_2"/>
    <dbReference type="OrthoDB" id="10829at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008813">
        <property type="term" value="F:chorismate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="entry name" value="Chorismate lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="Chorismate lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="165" mass="18325" checksum="A58330DC2922B392" modified="2014-10-29" version="1">MMVTTMTKEEAAGDFGRTVLEMIAALERRKGATLSIEQKILLAETGTVEQVLSILTGSAVKVKVVRQTLADSVIRREVIISSAASGRLLVRARSKVYCKVLPAEIVNKLMQEKRGIGTIIHNAGLETCRRLVRFGLGPGKHHPYRVYRIMHKGKTAFEIREDILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUM7</accession>
    <name>A0A075MUM7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PhoD-like phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00938</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUM7"/>
    <dbReference type="STRING" id="1459636.NTE_00938"/>
    <dbReference type="KEGG" id="nev:NTE_00938"/>
    <dbReference type="HOGENOM" id="CLU_020671_1_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="entry name" value="PhoD-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37031">
        <property type="entry name" value="METALLOPHOSPHATASE BINDING DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37031:SF2">
        <property type="entry name" value="PHOD-LIKE PHOSPHATASE METALLOPHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="694" mass="76950" checksum="ED3AC91865495FB1" modified="2014-10-29" version="1">MQDLNCRLDAQTILLGPILRRVDVNQVCVWVACSKPVTVKAEIFRFSDLQQDAKKPSVIGSGVTKSLRLGKRLHAALAIARPQPEQHGSAASFFPTDTLLAYDLEIITEVEDGIAAAGKRLADLGLASGENSISYYLQDSSLPTFFIKGDDKGPLNLLHGSCRKLHGKGEDCFAAADKVISKSFADIGNRPSALFLTGDQIYADDVAVPLARYLTEFGVALLGWEERIDGVDEKISDIAPGTRQKLVEKYAGFTSGQAENHLLAFGEFAAMYMLAWNEENWPVEFPDIASIPDNRQEKYRDQIKHLEEARRDLAAVRRVLANIPTYMIFDDHDVTDDWNITREWHDNAKYSKCGKQVIANALLAYWVFQGWGNDPSLYDPDFIGRISNYLGKNGDATAEEKTLFEDLFLNFHGWTFGAPTKPLAIFTDSRTQRHYDSFRGPPQLIGKDGLTAISRVAQLAGYKKGDPIIIVSAAPVLGFYLFEALQKALAVATSIYALDLETWYANTKVRTRFLSFLAREFAPRRCIIMSGDVHFGFTTRAAIAFSQENPKDMATTINVTQLTSSALKTTSLVKIAFISDILGRIRQLFPFKRIVRVGHAMIDDGGGGSNSDSGARRIDWIEARAIVRTAGSPLSPLIISDNNIGLVTIEKDLSVIHKLIVRKGGKDSKVYEAIAKMDRSPLEESLRARMLRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUW2</accession>
    <name>A0A075MUW2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioredoxin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02407</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701029.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUW2"/>
    <dbReference type="STRING" id="1459636.NTE_02407"/>
    <dbReference type="GeneID" id="41598118"/>
    <dbReference type="KEGG" id="nev:NTE_02407"/>
    <dbReference type="eggNOG" id="arCOG02007">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014051_4_1_2"/>
    <dbReference type="OrthoDB" id="28016at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02955">
        <property type="entry name" value="SSP411"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024705">
        <property type="entry name" value="Ssp411"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004879">
        <property type="entry name" value="Ssp411-like_TRX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42899">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42899:SF1">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03190">
        <property type="entry name" value="Thioredox_DsbH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006402">
        <property type="entry name" value="UCP006402_thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spermatogenesis-associated protein 20-like TRX" evidence="1">
        <location>
            <begin position="14"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="707" mass="79919" checksum="16980DCC1771B798" modified="2014-10-29" version="1">MHDNPHAANSGGKPNRLVQETSPYLLQHAYNPVEWYAWGEEALERAKKEDKPIFLSVGYSACHWCHVMAHESFEDDETAKIMNKHFINIKVDREERPDIDDIYQRVCQLATGTGGWPLSVFLTPNQKPFYVGTYFPKDGRQYGLPGFKTILHQLAEAYKSKKNEVEMASAEFMDALSQTARDVAALPAGEATKADVERSILDEAAMGLLQMGDTIYGGFGQAPKFPNASNLLFLLRYYDISGINRFRDFVVFTADKMAQGGIHDQLGGGFARYSTDQKWLIPHFEKMLYDNALLAQLYAELFQITKDEEHIAVLRKTLDFVIREMTHPEGGFYSAQDADSEGEEGKFYLWTKEEIREILQDQLAIDAFCERYGVTEGGNFEFKNILNVRSSVASIAQRYGKTPDEIARIIQDSSAKLFAVREKRVRPGRDEKILTSWNGLMISGFAKGYAVTGDTRYIDAAKNAVRFIESRLASSSDDDDDGRLMRTFKDGQSKLNAYLDDYAFYVSGLLDLFAVDSRPEYLEKAAKYTEFMVKHFWDDKEGNLFFTSDDHEQLIVRTKSFYDLAIPSGNSVAASNLLRLYHYTQNNGYLDKAARIMKSGARPAAENPFGFGQLLIAIYMYVKRPVEVTVVGKGGGMSGWLKSQFLPDGITAFVSEEKDLPALQKYPFFQGRSAEKGETAFVCRNFTCSLPITTEKELARQLGRQQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MV25</accession>
    <name>A0A075MV25_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Four-helix bundle copper-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01066</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MV25"/>
    <dbReference type="STRING" id="1459636.NTE_01066"/>
    <dbReference type="KEGG" id="nev:NTE_01066"/>
    <dbReference type="eggNOG" id="arCOG10152">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142273_1_0_2"/>
    <dbReference type="OrthoDB" id="8783at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd08026">
        <property type="entry name" value="DUF326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005560">
        <property type="entry name" value="Csp_YhjQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044543">
        <property type="entry name" value="YHJQ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37310:SF1">
        <property type="entry name" value="CYTOPLASMIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37310">
        <property type="entry name" value="CYTOPLASMIC PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03860">
        <property type="entry name" value="Csp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="117" mass="12807" checksum="8ED6265729DC4C9A" modified="2014-10-29" version="1">MSTSSSTSLQNSKWQSCIDACTSCAEACEFCATSDLKESDVKMMASCAQINRECAAICWTSASLMSMDSQFAKQFCDLCASVCDACAQECGRHNVDHCKMCAEQCRRCAVECRRMMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MV43</accession>
    <name>A0A075MV43_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mannose-6-phosphate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02478</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226986971.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MV43"/>
    <dbReference type="STRING" id="1459636.NTE_02478"/>
    <dbReference type="GeneID" id="41598183"/>
    <dbReference type="KEGG" id="nev:NTE_02478"/>
    <dbReference type="eggNOG" id="arCOG02427">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035527_4_3_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004475">
        <property type="term" value="F:mannose-1-phosphate guanylyltransferase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005976">
        <property type="term" value="P:polysaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02213">
        <property type="entry name" value="cupin_PMI_typeII_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001538">
        <property type="entry name" value="Man6P_isomerase-2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051161">
        <property type="entry name" value="Mannose-6P_isomerase_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46390">
        <property type="entry name" value="MANNOSE-1-PHOSPHATE GUANYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46390:SF1">
        <property type="entry name" value="MANNOSE-1-PHOSPHATE GUANYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01050">
        <property type="entry name" value="MannoseP_isomer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mannose-6-phosphate isomerase type II C-terminal" evidence="1">
        <location>
            <begin position="6"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="120" mass="13955" checksum="AFAD7B4BAE6C0B2F" modified="2014-10-29" version="1">MMKTNKEQRPWGWFEQFNENEPCTVKLIHVKAGSRLSLQYHEKRREFWKVVKGPAIVQINGKTFTGKTGDEFEIPTRARHRLAAKSSDALILEISYGHFDEGDIVRIEDDFGRTKDVLYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MV86</accession>
    <name>A0A075MV86_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03533</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MV86"/>
    <dbReference type="STRING" id="1459636.NTE_03533"/>
    <dbReference type="KEGG" id="nev:NTE_03533"/>
    <dbReference type="HOGENOM" id="CLU_613396_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="446" mass="51562" checksum="31A90B3AEC775C95" modified="2014-10-29" version="1">MAEYGARMEEFDKGVAAAQQADIEYERSGGEPIVLARYITFREFLSGSYMDWRDKALNEGLEILKYESTSATASQQQSKWSDYYSSQGQQAFQKITDFVKSDKAPNLRKFGEEVASQESQFFSLISRAPLAWFQGQVQHYTFEFYTEMNSLEGKWKAMSEQDRSVDDRVRNTSSQVLRLFDEVVKELVAEKRSGEENVKYIVGQAKKVPGVPLPIKVPLIAVDKMLERAGRLKKSSEELAQGYMDAYKLEESIVIVFAQTREGVREFLAKTNLDTAIKEFNAMNENSKGLADQCPTSKQKEDTKRFMEKAANIVSGFLEKFKQEYNEFVDDNRGIFVGPVSDKTLDELLEVRDWQKSWDDIERFNIQSKLKEVYDDCVKTWQVDLDGLTDEQKKELKDYWDMELRRLHDGLYEVIEGSVWDRIKRSHVDNRRQLNDTTKNSKGGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVH8</accession>
    <name>A0A075MVH8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein uL11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpl11</name>
        <name evidence="10" type="ORF">NTE_01197</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700062.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVH8"/>
    <dbReference type="STRING" id="1459636.NTE_01197"/>
    <dbReference type="GeneID" id="41597006"/>
    <dbReference type="KEGG" id="nev:NTE_01197"/>
    <dbReference type="eggNOG" id="arCOG04372">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074237_4_0_2"/>
    <dbReference type="OrthoDB" id="8842at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1550.10:FF:000007">
        <property type="entry name" value="50S ribosomal protein L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="entry name" value="Ribosomal protein L11/L12, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_uL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_uL11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_uL11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_uL11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020785">
        <property type="entry name" value="Ribosomal_uL11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_uL11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_uL11_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002232">
        <property type="entry name" value="PRK01143.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL11M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="Ribosomal L11/L12e N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00359">
        <property type="entry name" value="RIBOSOMAL_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL11 N-terminal" evidence="9">
        <location>
            <begin position="9"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL11 C-terminal" evidence="8">
        <location>
            <begin position="71"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIF83269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="160" mass="16361" checksum="70D6BBFDFCC4EB7D" modified="2014-10-29" version="1">MGDKKSISALVSGGEANAGPPLGPALGPMGVNVLQVVNTINEKTKDFPGMKVPVKVEVDAETKKFTVEVGIPPTAALVAKESGIPKGSGTAGKDYAGDLSMASAAKIARMKIDGSYAKDIKGAAKEVIGSCVSMGVKVEGKPAKEVYPDINAGKYDDLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVK4</accession>
    <name>A0A075MVK4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pyridoxal 5'-phosphate synthase subunit PdxT</fullName>
            <ecNumber evidence="7">4.3.3.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Pdx2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Pyridoxal 5'-phosphate synthase glutaminase subunit</fullName>
            <ecNumber evidence="7">3.5.1.2</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pdxT</name>
        <name evidence="10" type="ORF">NTE_01228</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + phosphate + 3 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31507"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="4.3.3.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the glutaminase PdxT/SNO family.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.6" evidence="7"/>
    <dbReference type="EC" id="3.5.1.2" evidence="7"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700090.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVK4"/>
    <dbReference type="STRING" id="1459636.NTE_01228"/>
    <dbReference type="GeneID" id="41597036"/>
    <dbReference type="KEGG" id="nev:NTE_01228"/>
    <dbReference type="eggNOG" id="arCOG00034">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069674_2_0_2"/>
    <dbReference type="OrthoDB" id="26717at2157"/>
    <dbReference type="UniPathway" id="UPA00245"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903600">
        <property type="term" value="C:glutaminase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036381">
        <property type="term" value="F:pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006543">
        <property type="term" value="P:L-glutamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008614">
        <property type="term" value="P:pyridoxine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01749">
        <property type="entry name" value="GATase1_PB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000010">
        <property type="entry name" value="uncharacterized protein LOC100176842 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01615">
        <property type="entry name" value="PdxT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002161">
        <property type="entry name" value="PdxT/SNO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021196">
        <property type="entry name" value="PdxT/SNO_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03800">
        <property type="entry name" value="PLP_synth_Pdx2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31559">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31559:SF0">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01174">
        <property type="entry name" value="SNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005639">
        <property type="entry name" value="Glut_amidoT_SNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51274">
        <property type="entry name" value="GATASE_COBBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01236">
        <property type="entry name" value="PDXT_SNO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51130">
        <property type="entry name" value="PDXT_SNO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="7 8">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7 8">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7 8">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <begin position="58"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <begin position="151"/>
            <end position="152"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR005639-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR005639-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIF83299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="214" mass="23317" checksum="825646CCB034F4C8" modified="2014-10-29" version="1">MSSNKDVTIGVLGFQGDIEENVAATRQALDELKIDGKIQLVRYAEDVEKIDALILPGGESTVQSSLAAIQHSLPSLKKRISEGMPVLGTCAGMIMLSKRVYDRVIGETKQKTIGNLDIVIERNAFGRQNDSFETDLKMNMLGKGAFRGVFIRAPAVSEVGKDVEIIARHAGKIVAVKQKNIIGTSFHPELAGDARMHKQIIKMALDFRAKSNGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVM6</accession>
    <name>A0A075MVM6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385155.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVM6"/>
    <dbReference type="STRING" id="1459636.NTE_01275"/>
    <dbReference type="GeneID" id="43502600"/>
    <dbReference type="KEGG" id="nev:NTE_01275"/>
    <dbReference type="HOGENOM" id="CLU_3112875_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="50" mass="5576" checksum="238AE29E052408D8" modified="2014-10-29" version="1">MGYRALNVMDVYAAYATFGIAMPLVLWFVCTHWKELNGLSLLGARKKALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVP1</accession>
    <name>A0A075MVP1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700154.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVP1"/>
    <dbReference type="STRING" id="1459636.NTE_01300"/>
    <dbReference type="GeneID" id="41597103"/>
    <dbReference type="KEGG" id="nev:NTE_01300"/>
    <dbReference type="eggNOG" id="arCOG10525">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2490609_0_0_2"/>
    <dbReference type="OrthoDB" id="12053at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="88" mass="9752" checksum="91B2375BEDE95A7D" modified="2014-10-29" version="1">MDPRVKKAVAAKIDEAISNADEVYRIQSKLGIAGGADFAFGIAIGRIYNSFHYQTRRILGRNATAAEFSEFLSLLSSRTPEIRRAFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVR1</accession>
    <name>A0A075MVR1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01326</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVR1"/>
    <dbReference type="STRING" id="1459636.NTE_01326"/>
    <dbReference type="KEGG" id="nev:NTE_01326"/>
    <dbReference type="HOGENOM" id="CLU_2695531_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="73" mass="8462" checksum="3CF21779D1BE0CF3" modified="2014-10-29" version="1">MSFYSQISIIVICATPKVTIYLKILENVIQKTILLQELGMGAVIDWTKTLMVLQAIYTLYNYGLYFRERPAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVZ2</accession>
    <name>A0A075MVZ2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="16">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">NTE_02750</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. The Rpo2 subunit (Rpo2N and Rpo2C in this organism) is implicated in DNA promoter recognition and in nucleotide binding.</text>
    </comment>
    <comment type="function">
        <text evidence="16">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 16">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="13">Part of the RNA polymerase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="16"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701305.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVZ2"/>
    <dbReference type="STRING" id="1459636.NTE_02750"/>
    <dbReference type="GeneID" id="41598439"/>
    <dbReference type="KEGG" id="nev:NTE_02750"/>
    <dbReference type="eggNOG" id="arCOG01762">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000524_5_0_2"/>
    <dbReference type="OrthoDB" id="6009at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000011">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1800.10:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007646">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007647">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019969">
        <property type="entry name" value="RNAP_Rpo2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006335">
        <property type="entry name" value="PRK08565.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007175">
        <property type="entry name" value="PRK09606.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03670">
        <property type="entry name" value="rpoB_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04566">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04567">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 16 24" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 16 24" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 16" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 16 24" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="20">
        <location>
            <begin position="21"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="19">
        <location>
            <begin position="170"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="21">
        <location>
            <begin position="412"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="22">
        <location>
            <begin position="511"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="23">
        <location>
            <begin position="598"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="17">
        <location>
            <begin position="647"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="18">
        <location>
            <begin position="1022"/>
            <end position="1113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF04566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF04567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="AIF84792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="1117" mass="124871" checksum="1FD0BE1B5A8C3B5E" modified="2014-10-29" version="1">MIENSIEMWPIINDILRREGVARQHLNSYNEFMERGLQSIIDEVGEIEIETAEYPYKIKLGKVKLQQPRIMELDGSITHVAPMEARLRNLTYASPIMLECSVVEDGKILESRFIHIGDMPVMVKSNTCILHNLPEVKLVEYGEDPRDPGGYFVINGSERVIVGLEDLSYNKIIVDTEETTGTLLYKAKVYSSIVGYRAKLELIMRPDGSIVTKIPGSPVDIPLITLIRALGLEADKDIADSVSLNEQIQDELEPSFEKAGDVASSRDAIVYISKRIAPGMLEEFQIKRAETLLDWGLLPHIGKNPENRHEKALFLGEAASKLIELKLGWIEADDKDHYGNKVIKFAGQMLADLFRTAFRNLIRDMKYQLERSGQKRGINAVAAAVRPGIVSDKLNNAIATGNWGRGRVGVTQLLDRTNYMSTISHLRRIQSPLSRSQPNFEARDLHATHFGRICPAETPEGSNCGLVKNLALSAIISVNVLSAEVTEKLYELGVQNVDEANEKLRAAGTRVFVDGRLIGYVEKGDVLAETLRNMRRSGKVHPHVGIYLYSSQNENATKRLYISCNAGRVMRPLVVLKDGKPLVTMEIIEKVSKKFLSWMDLLYMGVIELVDANEEENSYVAMEPKKVEAGKHTHLEIFPSAILGVGASIIPYPEHNQSPRNTYESAMAKQSLGFSTPLMNASTYVRQHFMLYPQIPVVSTKAINLLGLEDRPTGQNCVVAVLPFEGYNIEDAVVFNKSSVDRGLGRTFFYRIYEAEAKQYPGGMKDTFELPQADANIRGYRGEKAYRLLEADGAIMHEAVVNGGDILIGRTSPPRFMEEYKEFEVKGPYRRDTSVGVRPSENGVVDTVIITQSVEGGKMYKIRVRDMRIPEIGDKFASRHGQKGVVGMLVNQEDVPYTEDGLVPDVMINPHAFPSRMTVGMFMESLGGKAASLRGKIADGSAFLGEKLDDIKGAMEQYGFKYTGKEVMYDGRTGRRFPADVYVGVVYYQKLHHMVADKIHSRARGQVQMLTKQPTEGRARGGGLRFGEMERDCLIAYGASMMLKDRLLEESDKAEVNVCERCGLLAYYDVKQRRYVCRVCGEKAKISSVVIAYAFKLLLQEMMSLNVAPRLIAKEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MW13</accession>
    <name>A0A075MW13_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zn-dependent oxidoreductase, NADPH:quinone reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_02771</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84812.1"/>
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    <dbReference type="STRING" id="1459636.NTE_02771"/>
    <dbReference type="GeneID" id="41598460"/>
    <dbReference type="KEGG" id="nev:NTE_02771"/>
    <dbReference type="eggNOG" id="arCOG01458">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_3_4_2"/>
    <dbReference type="OrthoDB" id="8709at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051603">
        <property type="entry name" value="Zinc-ADH_QOR/CCCR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44154">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44154:SF1">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="12"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF84812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="350" mass="38391" checksum="DC59DAFD65BC2B95" modified="2014-10-29" version="1">MKAAVYREHSKDPRQVVKIEDIDTPKPKANEVLIKVEAASYNYNDLWGIWGEPIKIPMPHISGSDIAGTVVEVGENVTTNIKVGDRVASHPNLTCRVCYECTSGREYDCISRKVWGFQTGPLWGGFAQYTHLPEVNVVKLPDNVSFTDAAAICMVGMTAWHMLVTRAKIRPGQTVLIMGGGSGMGIAGIQIAKLFNCDVIATAGNKDKMDKCLELGADHAVNHREADWYKKVRDITNRQGVDIIYEHIGKTVFPQEVGLLKMGGTLVSTGATTGYDSAIDLRYLFFRGTNLLGATQGTKAGLEEVIRWVSKGRIKPVIDTILPFGNMVEGHVKMADSQLFGKIVTTPQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MW26</accession>
    <name>A0A075MW26_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02781</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84822.1"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MW26"/>
    <dbReference type="STRING" id="1459636.NTE_02781"/>
    <dbReference type="GeneID" id="41598470"/>
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    <dbReference type="HOGENOM" id="CLU_2067889_0_0_2"/>
    <dbReference type="OrthoDB" id="6073at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="119" mass="13790" checksum="F06C365608EAC2C0" modified="2014-10-29" version="1">MDTPRELEWYLRDHFFRQAGKGRTQFQRSAIAGEMASLYLRYRGYDPQQLAESMSPVIDDLVSMQVLKQTGDNLEVAGSLVRMQCAKCFYVSYLLADKEPKTCQRCSGTELHEFPKRKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MW58</accession>
    <name>A0A075MW58_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02827</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MW58"/>
    <dbReference type="STRING" id="1459636.NTE_02827"/>
    <dbReference type="KEGG" id="nev:NTE_02827"/>
    <dbReference type="HOGENOM" id="CLU_3245177_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="42" mass="4638" checksum="FB613EF2ACF1190F" modified="2014-10-29" version="1">MMMATITAVIVAAQRILQLSIDSSLPHAMVVEHFCMRALLSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWK2</accession>
    <name>A0A075MWK2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02992</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWK2"/>
    <dbReference type="KEGG" id="nev:NTE_02992"/>
    <dbReference type="HOGENOM" id="CLU_590015_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="463" mass="53612" checksum="34E92F491C2BBBB9" modified="2014-10-29" version="1">MLLADILKLKAELEKKSEDQLKELDLTNYELDFVLPYMLIDHIPKNLDLVMDIVERKLKVRWALHDSWAYLVNKVGAARFEEAMEVVDKWFNEPNLKTKISNIIPELCRNIDKIRLLPFLENWAKQDEVRLDTAMDSLSMVMFKVILDIGRKIPASDILKQAESKESEFLRRSLHLLEGIAKHKDLDVSFFIGGEENKIFQCASVIEAIKYYRDSLDYDQIRQAASIYHNIESFMGKSWFMKMKDERNKTNVVLRLMSFNDKNFLSNFNITLGNILSEKLPGTKQLRMNLQSKALRQDYATLSEIGFLSHFLRKSKIELYPSVGVKKLDFKIWISESPILFEVKNLAMYRYLKALEGTFITLPDTVKRKICTEYDEQLMSLDIDLPLLMAIDLRDSEAGIDEVGASTRYFEGKMKNLTGVVLFRNPLYHSSKSKTEGMIITNDFAINPLSPSTLEKLKQVLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWQ1</accession>
    <name>A0A075MWQ1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Small primase-like protein with Toprim domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01633</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700418.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWQ1"/>
    <dbReference type="STRING" id="1459636.NTE_01633"/>
    <dbReference type="GeneID" id="41597409"/>
    <dbReference type="KEGG" id="nev:NTE_01633"/>
    <dbReference type="eggNOG" id="arCOG01486">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140789_1_0_2"/>
    <dbReference type="OrthoDB" id="56459at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39964:SF2">
        <property type="entry name" value="UPF0292 PROTEIN MJ1624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39964">
        <property type="entry name" value="UPF0292 PROTEIN TK1411"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110455">
        <property type="entry name" value="Toprim domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Toprim" evidence="1">
        <location>
            <begin position="28"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="145" mass="16353" checksum="4F23577EE18076E1" modified="2014-10-29" version="1">MGYQANDEQVLEKLRHFVGMLNEESERGSVIVVEGRRDAEALSSIGFTGSPAVFHNFKGIADFVDCHGHGKNKIILLLDMDRTGKYLTSRLFSNLQSRRNHVSLFYKHALAKITNGKVRHVEDLSTYAQQMAGVTGARKDLYFYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MXB9</accession>
    <name>A0A075MXB9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700622.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MXB9"/>
    <dbReference type="STRING" id="1459636.NTE_01890"/>
    <dbReference type="GeneID" id="41597643"/>
    <dbReference type="KEGG" id="nev:NTE_01890"/>
    <dbReference type="HOGENOM" id="CLU_2055954_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="119" mass="13924" checksum="F0BC2C8E097DC199" modified="2014-10-29" version="1">MTASDDISPSKEMIERFDMSEEDIEDFKANQYRLKYDDEESVALWLGCKSSEFMLTDPKKAIQLVRASILTLGYNPPPLSKDDNATTDDYLEYMHIYGDFLRKYEEDAPARWAKEHVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MXD2</accession>
    <name>A0A075MXD2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glyceraldehyde 3-phosphate dehydrogenase (NAD(P)+)</fullName>
            <ecNumber evidence="3">1.2.1.59</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_01905</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.2.1.59" evidence="3"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_193354066.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MXD2"/>
    <dbReference type="STRING" id="1459636.NTE_01905"/>
    <dbReference type="GeneID" id="41597655"/>
    <dbReference type="KEGG" id="nev:NTE_01905"/>
    <dbReference type="eggNOG" id="arCOG00493">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069533_0_0_2"/>
    <dbReference type="OrthoDB" id="295712at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043891">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase [NAD(P)+] (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18127">
        <property type="entry name" value="GAPDH_II_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003251">
        <property type="entry name" value="PRK04207.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF83964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="349" mass="39521" checksum="22EDBD448579B9F3" modified="2014-10-29" version="1">MVLVKVFINGYGNIGRRLATALSADKEIQFVGVAKYTIDDKVKEALDNRYSVFVPENMVAAFKEKGYNVTGPVKDAVAAADLVVDAAKEGGGFENKKSMYEPMKKTAIFQGGEDRHGEMAVADMIHNSRVNYAKAQGRKYVIQGSCNVSGMGRIMQPLVEKYGPRIKRWDVSLIRRWADLEDTKAVKDSIEWDRHPHHQDDVKDFIPDANLYVDAFKVPSRMMHLHQMMIRFDGKAPSKDELLECYRNEFGVAILSSAKGTGDVRKKAMELGFAHGDTNMVHIHGDILRVQDDTVKLGYSDDQTGMVIPENHMLIQSMAFRRPREEALKRTDSLFQMSKKRKILEEEFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MXE3</accession>
    <name>A0A075MXE3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ORC1-type DNA replication protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NTE_01915</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in regulation of DNA replication.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the CDC6/cdc18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700641.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MXE3"/>
    <dbReference type="STRING" id="1459636.NTE_01915"/>
    <dbReference type="GeneID" id="41597664"/>
    <dbReference type="KEGG" id="nev:NTE_01915"/>
    <dbReference type="eggNOG" id="arCOG00467">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025112_3_2_2"/>
    <dbReference type="OrthoDB" id="195574at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01407">
        <property type="entry name" value="ORC1_type_DNA_replic_protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049945">
        <property type="entry name" value="AAA_22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055237">
        <property type="entry name" value="Cdc6_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050311">
        <property type="entry name" value="ORC1/CDC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014277">
        <property type="entry name" value="Orc1/Cdc6_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02928">
        <property type="entry name" value="orc1/cdc6 family replication initiation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763:SF26">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13401">
        <property type="entry name" value="AAA_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22703">
        <property type="entry name" value="Cdc6_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="47"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="59"/>
            <end position="63"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF83974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="387" mass="43644" checksum="618BECD8191CF232" modified="2014-10-29" version="1">MPESAIFADRSKLSPRYIPQELPHREAQVQQLVHAFSEAAHDPDRFPLTVLQVIGVAGIGKTTTVTKATKTIEERFAQNRLTLKMAYINLKLQGGNKFAIYRFLLERLAPDLPSQGLSAEEMLRYLLRYLRDNKQYAIIVMDEIDYLIKTSKDTSIIYDLTRLNEFEPDKPCNVKGVIFIARSTDFYSRLDPAELSTLGRVPLEFSQYTLEQVSDILSSRCARAFNPKAIGSDVIDKVAKITTSAEVNGDVRYALDLLLYAGNLAESQGTGRVTLEHVRKVHGQTHPSMTTEEIEQLSKNHIASLIAVVRALKSKKKQYVELKDVRLHAAELAEQLGIKKLDVEDYIDDLKARRLIEMRSLKEIGLHGASLAELEPVLLAKVKKQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MXG6</accession>
    <name>A0A075MXG6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01941</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700658.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MXG6"/>
    <dbReference type="GeneID" id="41597689"/>
    <dbReference type="KEGG" id="nev:NTE_01941"/>
    <dbReference type="HOGENOM" id="CLU_2730142_0_0_2"/>
    <dbReference type="OrthoDB" id="376716at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="71" mass="8010" checksum="EFB3B4E46856AA09" modified="2014-10-29" version="1">MAATKVQLLMFMIACFVSGGLAIGLSIIYGSSFFTYSIPGLVVGAFFAFKYATFDKNKARQEEHKRRRNRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MXK9</accession>
    <name>A0A075MXK9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integral membrane protein CcmA involved in cell shape determination</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03318</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701767.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MXK9"/>
    <dbReference type="STRING" id="1459636.NTE_03318"/>
    <dbReference type="GeneID" id="41598969"/>
    <dbReference type="KEGG" id="nev:NTE_03318"/>
    <dbReference type="eggNOG" id="arCOG04555">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2103587_0_0_2"/>
    <dbReference type="OrthoDB" id="10055at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="111" mass="11482" checksum="6C6FFA4C54D33E5D" modified="2014-10-29" version="1">MKILDGKRVGTVTFEEDGMLIGEVLGDVIVNGGYLELKGKVLGNVLVRGGSCRLTGIVKGNAVNEKGDLEVFGAVHGKVISKLGYTYVNPGAAVGGIENAHVKKEGKVTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MXS6</accession>
    <name>A0A075MXS6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03384</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MXS6"/>
    <dbReference type="KEGG" id="nev:NTE_03384"/>
    <dbReference type="HOGENOM" id="CLU_2313654_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="111" mass="13003" checksum="0F15616591EDDEF3" modified="2014-10-29" version="1">MSNTLDQISFEPLTSSEFEDFGKGTAKKRFYEVLAHIDEKGSMHYNDVMRYAFEQKLVRSRASITIILNGLTKMGLLERTVMDSRPMRTTYDLTRKVRSILELMKQVERNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MXW0</accession>
    <name>A0A075MXW0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03429</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MXW0"/>
    <dbReference type="STRING" id="1459636.NTE_03429"/>
    <dbReference type="KEGG" id="nev:NTE_03429"/>
    <dbReference type="HOGENOM" id="CLU_3056953_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="53" mass="5761" checksum="96411432CD9D1711" modified="2014-10-29" version="1">MTITFPDGWSGIQSRTENGTVVFMMPVENSAVQDDRTPITLSISKTEALSDEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MXY4</accession>
    <name>A0A075MXY4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03469</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MXY4"/>
    <dbReference type="STRING" id="1459636.NTE_03469"/>
    <dbReference type="KEGG" id="nev:NTE_03469"/>
    <dbReference type="HOGENOM" id="CLU_3263613_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="41" mass="4805" checksum="CBB8A70AFECA859F" modified="2014-10-29" version="1">MIDYLTIMAEKVVLKSAFFYLSKSVINNEMDLYTHICCIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MY99</accession>
    <name>A0A075MY99_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">3-isopropylmalate dehydrogenase</fullName>
            <ecNumber evidence="4">1.1.1.85</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_02175</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.85" evidence="4"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700842.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MY99"/>
    <dbReference type="STRING" id="1459636.NTE_02175"/>
    <dbReference type="GeneID" id="41597899"/>
    <dbReference type="KEGG" id="nev:NTE_02175"/>
    <dbReference type="eggNOG" id="arCOG01163">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031953_0_1_2"/>
    <dbReference type="OrthoDB" id="6813at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003862">
        <property type="term" value="F:3-isopropylmalate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004449">
        <property type="term" value="F:isocitrate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF34">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="3">
        <location>
            <begin position="5"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF84229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="342" mass="37201" checksum="61B19DAA8689BE23" modified="2014-10-29" version="1">MARYVISLIRGDGIGPEQTAAAKKILETISDNTSTKFKINEVEAGDAALAKHGKALPEFSVDTIKNSQACLKGPVGESAADVIIVLRRMFDLYANVRPAKSYPNIPALSPKVDMVMVRENTEDVYLGWEFNADPGTVVALRITSEKASRRIAEYAFKTAMMRDNKRKVVAVHKANVMRKGDGLFASVCREVAKKYPKIQYGELYVDAASMNLIRNPEQFDVIVTTNLFGDILSDEAAQVVGGLGMGPAANIGEGFALFEPVHGAAFDIAGRNAANPSSILLSAKMMLEWLADRHKDKKAAEQGARIEEAIVSLLKQGKKTKDIGGRLSTTEFTDLVAKEMFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MYN4</accession>
    <name>A0A075MYN4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02321</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700955.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MYN4"/>
    <dbReference type="GeneID" id="41598037"/>
    <dbReference type="KEGG" id="nev:NTE_02321"/>
    <dbReference type="eggNOG" id="arCOG01055">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_159725_0_0_2"/>
    <dbReference type="OrthoDB" id="140255at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038723">
        <property type="entry name" value="ArnR1-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14947">
        <property type="entry name" value="HTH_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ArnR1-like winged helix-turn-helix" evidence="1">
        <location>
            <begin position="4"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="100" mass="11161" checksum="6D5ABACD5E2FD3E7" modified="2014-10-29" version="1">MKNRSRLDIAATILDIAQDGAIKTRIMYEAFLSFPQVKEYLGLLQANGALEYAPDENKYYTTPRGRSFLLGYKEIGRLLSPKSSRLALSRLGMEETAVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MZ29</accession>
    <name>A0A075MZ29_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phosphoribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MZ29"/>
    <dbReference type="STRING" id="1459636.NTE_02460"/>
    <dbReference type="KEGG" id="nev:NTE_02460"/>
    <dbReference type="eggNOG" id="arCOG00041">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083583_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1310.20">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="1">
        <location>
            <begin position="22"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="225" mass="24112" checksum="467086D1636F7C9D" modified="2014-10-29" version="1">MLKNCAGKIYSAVRFRNRADAGNALAEILAPAVREKGALVLGIPRGGVVLADIVAGKLGAGFDIVIPRKLGAPGNEELAIGAVMADGTDYINRYVVIALKVKQEYIEREKEKQVAEIERRQSKYRKAGLPYDIRGRKVVLVDDGVATGATAIAAARWIKKQQPASLTIAAPVAPAQTVEALRHEADSVVVLAAPPDFGAVGEFYEDFAPVTDEHVMAIMLRRGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MZA6</accession>
    <name>A0A075MZA6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative ATPase involved in replication control, Cdc46/Mcm family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NTE_02537</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MZA6"/>
    <dbReference type="STRING" id="1459636.NTE_02537"/>
    <dbReference type="KEGG" id="nev:NTE_02537"/>
    <dbReference type="eggNOG" id="arCOG00439">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_395178_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF66">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="7">
        <location>
            <begin position="267"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF84584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="697" mass="78540" checksum="0A1AC600DD9EB96F" modified="2014-10-29" version="1">MPIELKSALENEGISRDSRFPIDSLTFIEAVKLLPVEIADRFKGEITRLKRFNTRLIIAGERPSHSTMAEESNPHSDPCAQCDQNFVSMTISEALRTTSSVKLSVKGVIVSQSLPYKVITKTMIGCNSCDQYDETEHNPPKFEESGIPKKCRNCGQKNLPKFDYATALSIQLQDPNPTGDLERLDIILYGKDTCNVIAGELVEIKGTSHIMKFITKKLTTVLHAESIKYHRRQELKVTEKDVENIYRFKDLGTKVTSVTKVTYIPTLRERLVSMVAPNVVGHKDKKLGILLSAVGAPENGKRGRIHSLFVGAPGTAKSMLARESIRLVPNSRYVSAQGASGKSLTAIIVMENENAVLRLGSIPLSKNGICAINEIGTMSFEDQKHLHDVMEEGDFTIDKYGIRQEIDSPTTIIATCNPIGSTWNSDHSIDMSEIPVKKEVLDRFDQKFVFRDFVTEESMRDYADAKMDYDERHIEHNYNFLRKYIAHAKTIYPTFTTEAREMLKEYWISLRSTGRATNRNLDALFRLSSAYARLHLETVVDKELVIELMEYYTTMLAEQGQLAETVRADPIEVAFKEIVKVVENAKKPIEFVEAARIACKNNERVGNYLGVNLVTRENKKLRNLLEMFQECTDSRVEIIQKKPLVLKWRVPSMPETNDIYDHEPKGKSCACPAHKDEEIVIASGNSCLSVGFKKGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N0W5</accession>
    <name>A0A075N0W5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N0W5"/>
    <dbReference type="STRING" id="1459636.NTE_03090"/>
    <dbReference type="KEGG" id="nev:NTE_03090"/>
    <dbReference type="HOGENOM" id="CLU_219264_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="37" mass="4453" checksum="88F0433FB6ECCD50" modified="2014-10-29" version="1">MSSNKEAEREEMKEENDELQDAEQFDLDEEEEEEGEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N128</accession>
    <name>A0A075N128_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03152</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N128"/>
    <dbReference type="STRING" id="1459636.NTE_03152"/>
    <dbReference type="KEGG" id="nev:NTE_03152"/>
    <dbReference type="HOGENOM" id="CLU_113595_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="212" mass="24789" checksum="FD418144393C3F5E" modified="2014-10-29" version="1">MEILVNESVYLIYFARFSGASTTLRSQHFNHPGPCIIEKVVGILRKREEDKEEKQKAVERFYALLKALMDELFEHAQKSKHIKMPKNVSFGLIYDQRDNILFTGSDSKTGKKMYLYNVRIIGKMFEEKRDQMLADQTTQTLFSWIADVCSIYISPFVYDYVVNVQHRGEGTAERTTRQIVRTFLDKLTSEPELKYVLDTIRDDNPQEKADQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N138</accession>
    <name>A0A075N138_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NTE_03162</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
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        <property type="protein sequence ID" value="AIF85194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701632.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N138"/>
    <dbReference type="STRING" id="1459636.NTE_03162"/>
    <dbReference type="GeneID" id="41598820"/>
    <dbReference type="KEGG" id="nev:NTE_03162"/>
    <dbReference type="eggNOG" id="arCOG04397">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_33_0_2"/>
    <dbReference type="OrthoDB" id="10960at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029:SF21">
        <property type="entry name" value="AMMONIUM TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="286"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="354"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="9">
        <location>
            <begin position="10"/>
            <end position="406"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIF85194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="408" mass="43314" checksum="A3C26A1C18966D39" modified="2014-10-29" version="1">MPIDTGDTTWMLISTGLVMLMTPALGFFEAGLIRSKNSLSILMQTFSGLAILSTLWFVLGFTLVFAPSQNGWIGGLDWLFFNNVPFNDSVDYAPTIPGVTFGSYQMMFAVITPLLITGAFAERLKWSSFFVFIIAWSIFIYYPLAHWIWGRGWLADLGVFDFAGGIVIHTSAGMASLAAALVLGRRKNFGPDIMVPHNIPLAVIGAALLWIGWFGFNAGSALASGSLAANTLLVTHIASATSAMVWIFLSWKRSGKPSTTAVINGAIAGLAGVTPAAGFIDAQSSFILGIVLGFASYYAILLLKEHWKIDDALDVSSVHGVTGIVGSLAIGILATQVVNPAGPNGLLFGNPMQFAIQALGVGVAGALGFGGTVVIMKVIDKTIGLKVKEEEEDIGLDITQHAERAYVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N1N6</accession>
    <name>A0A075N1N6_9ARCH</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03345</name>
    </gene>
    <organism evidence="1 2">
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        <lineage>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
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        </source>
    </reference>
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    <dbReference type="STRING" id="1459636.NTE_03345"/>
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    <dbReference type="eggNOG" id="arCOG08770">
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="185" mass="20633" checksum="3B70BD2A5F6D28B6" modified="2014-10-29" version="1">MPRINSRYKNSDRICSRGIKERCIIKSLARNPGQTRNSVAKDMARELGLPFSNAYGYVFKELEGCLVPNGIIQEAGRKKTKMGPRALQESGIPSFRLTEAGMIVAASLGELELQKRMEMVEKCLTSRAVANSSEFPFYESVLARFRSNPKAKLQLVETGVAEFIEGKISHPIIPLLEESKEQLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLE3</accession>
    <name>A0A075MLE3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00159</name>
    </gene>
    <organism evidence="1 2">
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        <lineage>
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            <taxon>Nitrososphaerota</taxon>
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            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLE3"/>
    <dbReference type="KEGG" id="nev:NTE_00159"/>
    <dbReference type="HOGENOM" id="CLU_2504793_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="85" mass="9668" checksum="60795D33788CAD53" modified="2014-10-29" version="1">MMMACARLNQKPPKFLIWQIVQSFCNLMKLHEFFVSSIGLSIYVLRLCLLDRLAKIKGTVECPACPSVIAKCINYCNVPLIVITY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLH0</accession>
    <name>A0A075MLH0_9ARCH</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00219</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
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    <dbReference type="STRING" id="1459636.NTE_00219"/>
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        <location>
            <begin position="21"/>
            <end position="47"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="146" mass="16422" checksum="26482A59745AB839" modified="2014-10-29" version="1">MTRKAERDNIKRSNLTDHRHIHYYIAAASTTGLAGIIHLALVVNAILHNVYTNTITLFLIGGIVQVFWIVPILKRWGRVWYSVGIAGTVVFIALWAITRMQGNPITHRASRVGPIDIATEVVQLAFIGLCIVILAIENRRIRKEIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLK2</accession>
    <name>A0A075MLK2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">NTE_00064</name>
    </gene>
    <organism evidence="1 2">
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        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158384855.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLK2"/>
    <dbReference type="STRING" id="1459636.NTE_00064"/>
    <dbReference type="GeneID" id="41596015"/>
    <dbReference type="KEGG" id="nev:NTE_00064"/>
    <dbReference type="HOGENOM" id="CLU_055771_2_1_2"/>
    <dbReference type="OrthoDB" id="302903at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
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    </dbReference>
    <dbReference type="InterPro" id="IPR009467">
        <property type="entry name" value="Glycolipid-bd_prot_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06475">
        <property type="entry name" value="Glycolipid_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159275">
        <property type="entry name" value="PA1994-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="183" mass="20195" checksum="4443A501F06CE9FF" modified="2014-10-29" version="1">MTIIVARWHTWAGDGWERLVLEEGPDGIIAESVLERTAYSTTYRIACDRSWRTREVKVRLLTGGKHIDLASDGSGNWTDDSGGASGAVLPYLSGSIDVDLSATPFTNTIPIRRLGLKLGESKDVSVAYVSLPDLAVTADLQRYTCIEPGRLYRYESVDGNFSRDIEVDEHGLVVTYPGLFKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLL9</accession>
    <name>A0A075MLL9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein required for cytochrome oxidase assembly</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NTE_00089</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLL9"/>
    <dbReference type="STRING" id="1459636.NTE_00089"/>
    <dbReference type="KEGG" id="nev:NTE_00089"/>
    <dbReference type="eggNOG" id="arCOG03103">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1529149_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050450">
        <property type="entry name" value="COX15/CtaA_HemeA_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35457">
        <property type="entry name" value="HEME A SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35457:SF1">
        <property type="entry name" value="HEME A SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF82173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="175" mass="19066" checksum="36582758BD5D28AE" modified="2014-10-29" version="1">MDRGQKRRRAESREGVTEKKTAAAEEPRLKRSIIVISFISLGLVYSVMLIGVFLSSGPITENGLACTDWPLCPNGLFGAPEGRYFIEYVHRLVAAVTAGFVYATAIIVPSSIRRAKMAAVIAAAIVSWQLALGFITVTTHLHPIAVASHLSTGISVFAFALLTFLWVGIWRKHGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MM00</accession>
    <name>A0A075MM00_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00429</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699469.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MM00"/>
    <dbReference type="GeneID" id="41596308"/>
    <dbReference type="KEGG" id="nev:NTE_00429"/>
    <dbReference type="eggNOG" id="arCOG08764">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1590793_0_0_2"/>
    <dbReference type="OrthoDB" id="10181at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="167" mass="17357" checksum="625A9BB246E64B5A" modified="2014-10-29" version="1">MNTKQTYTIAGISAIAAVIIFGAVAASQKNVQAQVNQNELFVAQKTGESAPDPLPGHSMHQAVLAVPPRDDGRIWDGDVTWTASQPVEIVVLHVYNSTGADDAHGEPLNAPFGNGKVAISLYKEASNTPAAGGSTHFTGSALAFHTLSGKPFTVTYSVKATALEPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MM01</accession>
    <name>A0A075MM01_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7 8">Threonine synthase</fullName>
            <ecNumber evidence="7 8">4.2.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NTE_00076</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>O-phospho-L-homoserine + H2O = L-threonine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10840"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.2.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the threonine synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.1" evidence="7 8"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699214.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MM01"/>
    <dbReference type="STRING" id="1459636.NTE_00076"/>
    <dbReference type="GeneID" id="41596024"/>
    <dbReference type="KEGG" id="nev:NTE_00076"/>
    <dbReference type="eggNOG" id="arCOG01434">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028142_4_1_2"/>
    <dbReference type="OrthoDB" id="6371at2157"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:threonine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004795">
        <property type="term" value="F:threonine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006565">
        <property type="term" value="P:L-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01563">
        <property type="entry name" value="Thr-synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050147">
        <property type="entry name" value="Ser/Thr_Dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004450">
        <property type="entry name" value="Thr_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026260">
        <property type="entry name" value="Thr_Synthase_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006050">
        <property type="entry name" value="PRK08197.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00260">
        <property type="entry name" value="thrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078:SF6">
        <property type="entry name" value="L-THREONINE DEHYDRATASE CATABOLIC TDCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038945">
        <property type="entry name" value="Thr_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 8 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 8 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="11">
        <location>
            <begin position="70"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="374"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="10">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="NCBIfam" id="TIGR00260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR038945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR038945-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR038945-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIF82160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="406" mass="43605" checksum="1B1806E772678C50" modified="2014-10-29" version="1">MGSIKSLKCRECGKEYEPQFRYVCEECFGPLDVTYKEASSINRHTFDLREKTYWRYFELLPVADKANIVSLNAGLTPLQHADKLGERLGLKSLYIKNDSVNPTFSFKDRPAGVAVSRAKETKLNAVGCASTGNLASATAAHAAKAGLPCYIFAPSDIEHVKIAQALSYGAEFVAVEGTYDDANRVASIIGDSKGYGIVNINMRPYYVEGSKTLAYEVAEQLGWEVPDRLVIPVGSGAMLNAICKGFEELHALGLIGSVKNLKIVAAQPHGCAPVVDAFKRNSDEVIPVERPETIAKSLAIGDPGDGIYVLKRLKQYGGLAEEVGDEEIRDGIMMLAQSEGIFTEPAGGVSVGVLKKLVEEGRIDRDEKVVCYVTGNGLKATEAIIGVLPKLTAVKPDAAAVSAMIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MML6</accession>
    <name>A0A075MML6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00411</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699453.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MML6"/>
    <dbReference type="STRING" id="1459636.NTE_00411"/>
    <dbReference type="GeneID" id="41596291"/>
    <dbReference type="KEGG" id="nev:NTE_00411"/>
    <dbReference type="HOGENOM" id="CLU_2766244_0_0_2"/>
    <dbReference type="OrthoDB" id="375671at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="69" mass="7138" checksum="5C2B4F86BCF54D0B" modified="2014-10-29" version="1">MASRAGIIGIFAAIGFAIGFMAYLATPAVGQYLKDMWPMLDQSIILAMICGGAGAAISTITVTAWAKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMM4</accession>
    <name>A0A075MMM4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Apea-like HEPN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMM4"/>
    <dbReference type="STRING" id="1459636.NTE_00003"/>
    <dbReference type="KEGG" id="nev:NTE_00003"/>
    <dbReference type="eggNOG" id="arCOG09518">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1426389_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041229">
        <property type="entry name" value="HEPN_Apea"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18739">
        <property type="entry name" value="HEPN_Apea"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Apea-like HEPN" evidence="1">
        <location>
            <begin position="49"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="204" mass="24387" checksum="3E2DAE7D1A99BD5A" modified="2014-10-29" version="1">MLFSYRDIGEQSRTYLENWFKKKETLKPLFDLYFGVLHNKQTYLDHKLLSLVQALESYHRRVFKTTETSKEEHEARLQEIFDATPEKHRSWLQRKLKHSNELSLQNRLIELVDVYKELLCNFIQKPGEFTQQIADNRNYLTHYDPRLTSRAIRDSELYAVTEKLKVLVELFLLRELGVDDASIKKIIEKRIRNILELLNGPDSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMM8</accession>
    <name>A0A075MMM8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Plastocyanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00313</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699386.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMM8"/>
    <dbReference type="GeneID" id="41596218"/>
    <dbReference type="KEGG" id="nev:NTE_00313"/>
    <dbReference type="HOGENOM" id="CLU_088474_0_0_2"/>
    <dbReference type="OrthoDB" id="4392at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052721">
        <property type="entry name" value="ET_Amicyanin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36507">
        <property type="entry name" value="BLL1555 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36507:SF1">
        <property type="entry name" value="BLL1555 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="274" mass="29166" checksum="2F23F69C534A327D" modified="2014-10-29" version="1">MVNRNVMMGAIIAVGILVATASLAVSSIAAQPGGNMMQKGQGTGQGQGNSTNDSSSNMTKTTMMQGGSSGTGNQQNDERPSVQYQLNKKYHDYKDGVSTVRAGAGGHVAPLTIFFPNHAEVKVGEKVAFINPTRVSEPHTVTFMFDNSTFADFAAPFVIDNSTSIRSAVPNANAEPVVMPGQQNGTKVIVALNNRSFMPTVIDSSGKVTYLPPNGNYTITGTEKYVNSGWIWPKGMSPPGLPPIDSFQVTFSKAGTYSYYCQVHPWMAGDVVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMS6</accession>
    <name>A0A075MMS6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NTE_00373</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMS6"/>
    <dbReference type="STRING" id="1459636.NTE_00373"/>
    <dbReference type="KEGG" id="nev:NTE_00373"/>
    <dbReference type="eggNOG" id="arCOG02814">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033716_0_2_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11032">
        <property type="entry name" value="P450_EryK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000018">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46696:SF1">
        <property type="entry name" value="CYTOCHROME P450 YJIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46696">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF82455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="419" mass="47171" checksum="59E5CC3E5F0FBF1A" modified="2014-10-29" version="1">MWIIVWMQKSTSSNYNNEKLNPFPFYSVMRKNNPVEYNEKADVWNVYRYDDIKKILTNYVDFSSDFTKAATRFQDEPFRRSLLSSDPPVHRHLRSTISSAFSTTTIERLEPRIREIANDMIDKVIEKGSTDLVRDFSYPLPVTVIAELLGIPAKDRDLFKRWADELLKSIDEAVETGNPRRNNDKLQKLQKEMDDYFLKVIAEKRKKPGQDLVTQLINAETDNKKLSQDDILSFCALLLQAGHLTTVNLINNCVWSLLEHPKQLARLKSNPSSSSPSSSSSSLLTSAIEETLRYRSPVQALVRFTTKDVQVGGKAIKSGQRVITWIGSANHDEVVFGNSEEFDIMRNPNPHVAFGAGIHLCLGAPLARLESHIAMEILLSRLQGLELGDDPKNLEPANGSAFLYGIKSLPLSFEAAAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MN57</accession>
    <name>A0A075MN57_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA (guanine(37)-N(1))-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.228</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">M1G-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">tRNA [GM37] methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NTE_00608</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>guanosine(37) in tRNA + S-adenosyl-L-methionine = N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36899"/>
            <dbReference type="Rhea" id="RHEA-COMP:10145"/>
            <dbReference type="Rhea" id="RHEA-COMP:10147"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.228"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.1.1.228" evidence="1"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_193354084.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MN57"/>
    <dbReference type="STRING" id="1459636.NTE_00608"/>
    <dbReference type="GeneID" id="41596471"/>
    <dbReference type="KEGG" id="nev:NTE_00608"/>
    <dbReference type="eggNOG" id="arCOG00033">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022610_0_0_2"/>
    <dbReference type="OrthoDB" id="8079at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052906">
        <property type="term" value="F:tRNA (guanine(37)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002939">
        <property type="term" value="P:tRNA N1-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.110:FF:000001">
        <property type="entry name" value="tRNA (guanine(37)-N1)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.110">
        <property type="entry name" value="Met-10+ protein-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030382">
        <property type="entry name" value="MeTrfase_TRM5/TYW2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056743">
        <property type="entry name" value="TRM5-TYW2-like_MTfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056744">
        <property type="entry name" value="TRM5/TYW2-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245:SF36">
        <property type="entry name" value="TRNA (GUANINE(37)-N1)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245">
        <property type="entry name" value="TRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02475">
        <property type="entry name" value="TRM5-TYW2_MTfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25133">
        <property type="entry name" value="TYW2_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51684">
        <property type="entry name" value="SAM_MT_TRM5_TYW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="SAM-dependent methyltransferase TRM5/TYW2-type" evidence="10">
        <location>
            <begin position="25"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIF82688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="283" mass="31060" checksum="798CB2761141EB4D" modified="2014-10-29" version="1">MPHMLKNVLAGVLTAEEASQVYSAFDQVGDIVIIKIPDSLAAKKQVIAEAILANVKTAKTVFAQASAVKGDYRIRELEFVAGENRTITEYREHGCRFRVDVARAYFSPRLSTERQRIASLVQDRETIVNMFAGIGTYSIIIAKAVKTCRVYSIDSNSVAHDLCIENAKINKVADRVVPICADASEAIKSQLAGVADRVIMPLPERAKEFVEPAVLALKKHGGVVHYFAHVKADGKQKAKEEAGAKDAKEVFAPYSYEILGTTVVREVGPRIYQIVADVKITKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNC4</accession>
    <name>A0A075MNC4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Activator of Hsp90 ATPase homologue 1/2-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_00976</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987170.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNC4"/>
    <dbReference type="STRING" id="1459636.NTE_00976"/>
    <dbReference type="GeneID" id="41596805"/>
    <dbReference type="KEGG" id="nev:NTE_00976"/>
    <dbReference type="HOGENOM" id="CLU_108923_3_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd08899">
        <property type="entry name" value="SRPBCC_CalC_Aha1-like_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="ASHA1/2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Activator of Hsp90 ATPase homologue 1/2-like C-terminal" evidence="2">
        <location>
            <begin position="38"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF83051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="182" mass="20732" checksum="406CE62CC3FA01CB" modified="2014-10-29" version="1">MDVQEMKDAKPSDINNQVGTVTIEGEYATLRYERRLLHPPEVVWKAITDPKEVAVWFSTSAKIDARPGGAIEYISVPVGFRRTGRILVWDPPRVFEHEWRIDPHPQLPNGEAESIIRWELVRDAGQTILMVTHSRLTKDNGLRFAPGWHAFLDRLTAQLDGEKKLPDLMERIAAVKGLYPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNE7</accession>
    <name>A0A075MNE7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01002</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNE7"/>
    <dbReference type="KEGG" id="nev:NTE_01002"/>
    <dbReference type="HOGENOM" id="CLU_494027_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="643" mass="70813" checksum="54135B922314E794" modified="2014-10-29" version="1">MKFISLILIALIFVAPWLFELYTFHLYEINDNTFFFYSGARLFFFVASAVALGYFAGLNIRKGGNVNYYIIGCAAAVLSLVLVLYQFCEARECYYVGPDGLGEVRLFLLLFSASAAGLIRGKWARLTLNNDDEGDEYDKAAIAATSSPSSIHPLFASTVVAIFVGIYPASLLYDVPSEPTFRALLFFYYVTVPFLLAGLTASQLGSGNNNSSQKWAIGASVLGQTVLFVLFEALTFPDNNNDDSFWQVIQLVVAIGGSALSGIAGSRIGYSYYHHHRRHLVQPNNNHLNANGPKGMMASSKKLKMTREKLFASLSVPIFFGFGIFAMHPSFLAPIDLLPDIENVGSSGHQDGGNCPKMLSSIPPPMYYSGAASNEQYFSTKRVEVNLNFTSLYQHQGIDNNTSSLSSRNENTGNDDDNDILLAGIGAQSPNCCKDGLDYGYRADVLFTKEGTKYLVARAWETCDQNAACSGFPWRSIMHESVVPINNNIPKSFLAIAMEWARDGRTVNWYYRTVDSDSWIKYSSFTAPEIENPYFNLGVISINGFFPADNPLVTSLWGNVNFFQAGIATTSSSSDSTAFAGGKIVFECPAFYDNNDGMKHCFPNMAAVPASESEWKVLWGWGVDRPATSTHIDNLKKLVEMII</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNI3</accession>
    <name>A0A075MNI3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00678</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_264357936.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNI3"/>
    <dbReference type="STRING" id="1459636.NTE_00678"/>
    <dbReference type="GeneID" id="75933608"/>
    <dbReference type="KEGG" id="nev:NTE_00678"/>
    <dbReference type="HOGENOM" id="CLU_3245484_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="44" mass="5055" checksum="8FC047AEE8C02B2A" modified="2014-10-29" version="1">MMYGPLCEKCLHPLERHGYVLTKLDGKEVRRCEIGVCTCVIMTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNT6</accession>
    <name>A0A075MNT6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein P1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl12</name>
        <name evidence="6" type="ORF">NTE_00715</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699695.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNT6"/>
    <dbReference type="STRING" id="1459636.NTE_00715"/>
    <dbReference type="GeneID" id="41596568"/>
    <dbReference type="KEGG" id="nev:NTE_00715"/>
    <dbReference type="eggNOG" id="arCOG04287">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114656_2_0_2"/>
    <dbReference type="OrthoDB" id="3337at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006414">
        <property type="term" value="P:translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05832">
        <property type="entry name" value="Ribosomal_L12p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1410:FF:000002">
        <property type="entry name" value="60S acidic ribosomal protein P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01478">
        <property type="entry name" value="Ribosomal_L12_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027534">
        <property type="entry name" value="Ribosomal_P1/P2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022295">
        <property type="entry name" value="Ribosomal_P1_arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03685">
        <property type="entry name" value="ribo_P1_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45696">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45696:SF10">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="70"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF82795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="103" mass="10467" checksum="6ACCA734B2CA3A61" modified="2014-10-29" version="1">MEYVYAALLLHKLKQNITEDNVKSVVKAAGVTPDDVRVKALVAALSEVNIEEALKAAPVAVAAAAPAGGAAAAPAGGAAPAKEEKKDEKKEEEALEGLSSLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNW6</accession>
    <name>A0A075MNW6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699728.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNW6"/>
    <dbReference type="STRING" id="1459636.NTE_00757"/>
    <dbReference type="GeneID" id="41596608"/>
    <dbReference type="KEGG" id="nev:NTE_00757"/>
    <dbReference type="HOGENOM" id="CLU_2613421_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="78" mass="8381" checksum="D2579CC71CB655A1" modified="2014-10-29" version="1">MGVLTWILVGVVVLAVLGLGVRTFLSGLQQGVEKIANAPIIKDAAAKAKQLVSEGKDELENSFKEDYHQEENAITNNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MP30</accession>
    <name>A0A075MP30_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_00476</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699506.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MP30"/>
    <dbReference type="GeneID" id="41596350"/>
    <dbReference type="KEGG" id="nev:NTE_00476"/>
    <dbReference type="eggNOG" id="arCOG02644">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_15_11_2"/>
    <dbReference type="OrthoDB" id="135877at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.10">
        <property type="entry name" value="Tetracycline Repressor, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050624">
        <property type="entry name" value="HTH-type_Tx_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43479">
        <property type="entry name" value="ACREF/ENVCD OPERON REPRESSOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43479:SF11">
        <property type="entry name" value="ACREF_ENVCD OPERON REPRESSOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="2">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF82557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="233" mass="25664" checksum="7C37853AC370D426" modified="2014-10-29" version="1">MKPDRQEKVDRILRAAAVVLAEKGYENATIKDIAAAAHVNWGLLHYYFKNKEDLVVKTLRYASDAAFTPTLGLFSEGRSKEEIVDNAIELLKRTYRDNPGFYKLLFEMWCASGRSKKIKAELVDCVNRVIESLRTELEKISSSAVPTAPTATAAAAIPGASFADIPHEESTGIAGLLLAMSNGLAFQLILDPQKLEDEKTWQPFRVAALVLLGGDVNEANSSNNNKKKKNDKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPF1</accession>
    <name>A0A075MPF1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01363</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPF1"/>
    <dbReference type="KEGG" id="nev:NTE_01363"/>
    <dbReference type="HOGENOM" id="CLU_3002960_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="56" mass="6393" checksum="84A60A787C6E09AB" modified="2014-10-29" version="1">MRYWSGIVKKTDVPFVIMPASNHNASFGPGFASDIRNMLKVEEILWNNKTETKLPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPK0</accession>
    <name>A0A075MPK0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01422</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPK0"/>
    <dbReference type="STRING" id="1459636.NTE_01422"/>
    <dbReference type="KEGG" id="nev:NTE_01422"/>
    <dbReference type="eggNOG" id="arCOG08641">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2177767_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="126" mass="14806" checksum="F20F4E53539CD734" modified="2014-10-29" version="1">MITGILSASGRSIAVSQEPPIEYAASKINNTVKNLREGLDPDILAYWYKRVEDRSRELVPEHLKDKVHFEQDRILWMKFKMDVSKRAVPTVMQVIEEYIPMMPYSTGLYFRKVQEILTEEMNKDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPL2</accession>
    <name>A0A075MPL2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_01437</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700261.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="STRING" id="1459636.NTE_01437"/>
    <dbReference type="GeneID" id="41597232"/>
    <dbReference type="KEGG" id="nev:NTE_01437"/>
    <dbReference type="eggNOG" id="arCOG02542">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000170_0_0_2"/>
    <dbReference type="OrthoDB" id="3296at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="3044"/>
            <end position="3067"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="3074"/>
            <end position="3091"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="193"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF83501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="3221" mass="337564" checksum="7E5C1970BECD2A2E" modified="2014-10-29" version="1">MLTPRSLSGMMRDRSLLLLFGLAAAAALFLLVANPGQAFAELSPTHSQNAAANTAADQSTTSPRVFSRSIGDSVAVASTFDNLGARVPRVFNVGISDGLNIATSPTPPPPSSAATSTTSPRPSTGLQGAGRAEEKLGPRNPAESKGDLTNNKDQKNGSVQEQPQSSISQELESVLSTLMQDLLGSDDSEPDDSNSSPQSIPVQVPPTIYIDSLYGAYAIAVIAISVGKSPRVVSMRRRIVGLYAVKSEDESRDAEMPMYARVTIIVVVIVTAVAMASAAGPVVGEAFADQAAGIAYKKGTTGGVGYRQWDPATASWSSEVAMTTGVVSDIYAVKFLYSPVSQLKVIGVIESNGEIDIYYCEFACTTASNWTGPTLVADVTTTTITAGFKYFDMAFESTSGDLLIVYDKVTTTDTNDFFYKTFNPASGLSGESGFNYNTGDGTSDNDIRYFKMASKPGSDEIAMILLDATAQDAIAFRWTGSGFTSQQTISSALGTTSITGEAIGIAYETSSGNILAVSGNGANSMTYGRYTGTWTTGTLNPNTSTTFEDVKWVSLKPDPSASSNRIMICDIDDQSDWNCAATNGSTIPASLTQLESNTATSTRRPADFAWDATGSTGLTLYYESGSADLKRRTYTSGAFNAESAAISVTNAIRWVAAATDDDTNANAVDSLWAIYGDATNDAIGDAEWDGSAFTLNGETTITNNAGGTNTIEAFGLDFRHSPGSRSISQTITVSDSITAAKSKLRTISETITISPAIIKQVTHPLPNTLTVVDSIARSVTVTPDSNVAGMAYRSDDGTNGSSSPKYREWNPTTKTWSSQVELESAGSPIRNAWIEFSPVSTKRVIIVLSDDGTLDSYVCDFGCTTPGNWAVTHDIVDLWNAVTPAIQKRPFDIEFEKTSGDLMLVYDKEDGGDSTTDLFYRIMPDSSTTFGSENAIDDTGSGAPDNVYSFVRLDSRKTSGSNDLGLVAASETNHRAVAWYFNGATQTFGNINTLTTSTSTDINYEGVGVAFETSTGDLVAVAADGADVVYSQFSGGSWSSISTVGSMDLDTVKWVRLVPNPNAGRMDMQLVASGPHGSFNGLSSAYWSGSAWTVYDSDGAPVGSDDNLHAGTTASNSIDSTETRVFDFAWNNADDSLRGILVWGKSNQLSFKRFAATSSWTSALTITDDGSTHPWVSLNEHTNPTSADAVSVLGAAIDSDADISQLRWDGGTTAVFAWTDDGASTVGNTSPESFHVDFRRSPVLKKFPSITLTVADALAAKMRAKVFPESVTIVVSVVAEKGSPLDSARSAAVYRSGTGSATFNSPKYREWDPATQTWSAEVELPNTGSAIRDAIIRFSSDSSLRVVVSHSSDGTLNLFTCDNNCASASSWTLVAADFADTGSPDPSKPYRPYDMLFETTGERLVIVYDKELTENADFYYRTFDGTTLSAETGVNLAGGSADAEELRYLHLAAHSTTNEMTLAVLDATNLKTYGAVWNGSAWGNVQTVSSSLSLENIDGDSVDVAYEAQSGASLVLSGNGQNSAAYARWTGSSWTTGATNPNPGVTTEDVKFVSLKSDPLSSSNKIMACQSDDGSALSCSQFNAGTPGTWTVVTGNTGTTAGRAFDFAYNPAGTTGLLVSSSGASGTLDYRAFNGTAFGTAATLSAAGTHKWVLGASAISTTDVVNSMFLKSNSNFDTGAIKSKAGKTTLVGDASLTSESGNDTYESMHIDFQKSKKVKRTSADTITIVPSVARGIGKSLSDTVTIAPAVSKGVRKPLSDTINISAVAAKNPKVAIPIAISVSDSVRKKVTRSLPSTITIQDSITTITIVRPSVTLSIADSVAGHKGAARSVSDTATIGVSVSWMYHASRSASDTLSVSAAVSTTLHPTRSVSVTLSVADAITKSTTKSLSDAVTVLPSVSRTYSPSRSMSDAVTVSPAVAKVYLASRSAAEVVSVSDAVAGTSAFARAIADSVSLADAAARQSVAARSAADAITVSDAISSRTLLASRSLSDTLPASDSINKSISRSVSDAVSIADVIIKSATRSLSETLSATDAISPTATRPLSSTITITDAISHSVSRSLSDSVAVADSIAKRASRSLSDTLSAADSVSRRASTSAAETVSIADAIATTARRSLADSVTMTDSTSYVASRSLSDSISTTDAVSITVSRSLSDSVSITPAINSTTSRSMSDSVPITDAITTAVSRSLSDSVALADSVSTSVSRSIADTVSVTDAIARAAADSRSTSDSINVTDALATTTSRSLADSIAITDAITGKTSRSTSDTLSATDAISTSVSHSLSDAVSMTDSVTSAASRTMQETLSVTDTAATNAPRSPSDLMTVEDAIATSTSRSLSDAVGVTDAASSSTSVLASVSDSLAVADSISTNNINRVAVSDSVAAADSVTGALAASRLVADALVIEDATGAPTSFAREISDSLVIADGVSGGSSISVPVSDSLALSDAIARTGSGPFSDAVAVADSVSIGISRFLADAMPMADSVALPIPRTINDALVLADQVSAKAGTAVSVVDSLGVNSQITDVSVHWNRVFEEGVDLADCTPFSCNQSLHFDEGLNLADGDFFTSPPGRILPTTLAVTDSIAVNRPQTFITLGDSAAVSVAIKPLLPILVNDHADNHGRPPNLSVPGTYTWDGTPADLRDAIELDPLYFNTTVIRDDLPNQIITLRLRDVTIVPTADLPANNTLISDRAANIPAGVPVQVRVNFMDTPALSGHSGFIQSLDVQFTPAMLTTDFGLIVTPMDVPPAGATLPPEELRPLYIDVRWWGNVPGGSDPSVQSYYQHPPTFTFTVTDDWARSESAARDANGVPLIKIRLLNEGTNQWEEVNTVQNLSAGNGTYTFTATLPHFSDYVITAVKSATAGSGTGTSSSHVPPPPVVPKTFAVNLADSLTLATSTSNKAVAVIEEFVNEKFSARLLDSVKISSRPVAYNTFTILKDVDVSITVVDVKQKDVAPPSATAVLQTDITNAGDQAEKFTLNFWYNDQTGKRAFDLSQQVEVEAHGSKTLQVTIPFTEPGTYRVTAEARSVPENDLLESTQLTVVVPWLSVYLYVLMTVAIAILGGSAIAIALYMARNGMMITAAGAGTAGALILLLGRKRKPRVRVAERKLADNDDDDDDNYDLLVNVKLANGSEGRLAPGERMALFDFEIINRSRRKQEFVLAYHLVDMAGTTMPESAAEIKIGKRKIQLRKAKIELLAGAYVLHVEARTAKGEVLSSDRVSVRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPN7</accession>
    <name>A0A075MPN7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPN7"/>
    <dbReference type="STRING" id="1459636.NTE_01462"/>
    <dbReference type="KEGG" id="nev:NTE_01462"/>
    <dbReference type="eggNOG" id="arCOG08742">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067489_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="352" mass="37112" checksum="ADCDF849793B9777" modified="2014-10-29" version="1">MLFATLLAFSVAPAAFANDMNAVLVPQTDKAEGHYVAVKNITLRYPSGSPISQELNGKQDRIQFTVKGNTSSTDNGVANAIAAFNKALLQARSPAVVTNMTITYTGVLKGAPDNAAITLKIEAVPQMEKIVISGGGNGSGGGNQSASSSASQAVDLEWRRITVTDPILLKAPDVGEIEITKPINFLDKTHKDLAKQIFDSQLSSMFNTSILNFDRFKQPMSTWHFLFDPSGSLVESSSFFKESSGAKVVSIYSLGESSFREGTFQPEEEDATATIGGAQVQAHSQVPAPSGQIQISGFSSLDQAAGGNFAVVTAEAPAGAQQATGNFPIQVLLVLGGMMGAIAVFILFKARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPN9</accession>
    <name>A0A075MPN9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative cobalamin binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_00729</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699705.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPN9"/>
    <dbReference type="STRING" id="1459636.NTE_00729"/>
    <dbReference type="GeneID" id="41596581"/>
    <dbReference type="KEGG" id="nev:NTE_00729"/>
    <dbReference type="eggNOG" id="arCOG03402">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG03932">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_920149_0_0_2"/>
    <dbReference type="OrthoDB" id="111719at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1240.10">
        <property type="entry name" value="Methionine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003759">
        <property type="entry name" value="Cbl-bd_cap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036594">
        <property type="entry name" value="Meth_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02607">
        <property type="entry name" value="B12-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47644">
        <property type="entry name" value="Methionine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helix-turn-helix type 11" evidence="2">
        <location>
            <begin position="14"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="B12-binding N-terminal" evidence="1">
        <location>
            <begin position="86"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF82807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="306" mass="33898" checksum="D6CD5A2CBC459122" modified="2014-10-29" version="1">MSMYRRYTLDEVKRKIVDVLQNAGTGLSGVELADKTGINRMTITKYLDIMNTMGLVKKKKTGTVNVWFLETGISDIEFPVNYVQVQQRLIDFALAGEEEQARRLLISVLNSNIDQVKIITDVILPAANTVGELYSRGRLGKTERAHLASMMVEFIDLVKFNAHPAEPKMNAHVLCVAGTDDRAHLAKSAAVVFQILGWDSRYVGSVEQDIDPFFDIDLQRYVSKAWGNKHGLMLMCVFSSGEGPLRFIASTVKAIGGRLKGELRLAALAPEAEAAAGENADYAAKDLQGIVDWAERQYILIVSSRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPV7</accession>
    <name>A0A075MPV7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fe-S oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPV7"/>
    <dbReference type="STRING" id="1459636.NTE_01087"/>
    <dbReference type="KEGG" id="nev:NTE_01087"/>
    <dbReference type="eggNOG" id="arCOG01357">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032214_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="entry name" value="tm_1862 like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42731:SF4">
        <property type="entry name" value="RADICAL SAM DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42731">
        <property type="entry name" value="SLL1084 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01082">
        <property type="entry name" value="B12-binding_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Elp3/MiaA/NifB-like radical SAM core" evidence="1">
        <location>
            <begin position="268"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="575" mass="65151" checksum="181DDEEACBD29101" modified="2014-10-29" version="1">MSKHPKIVLTADRTLMSPYRGISLASFFGCAPALDMNRSHDSFWYRILGNQVTPRILFDFICNPIEHTNGYANYAPYGLRKVEAALLRDGFAREDVVVAHPDYVEQFIGPETQVVGTYEMDPLGMGPVTMTFTYGRKQQSYDEFYNADLHHRISAAKKRTGSKARVIAGASGTWQYNYDPAKIEEYDLYGIVEGELGGIGPEIDGAAGPFFDALIGGEFDMANPFKKSQFKVEIKEFVRSDRTYHGRFIHYWNEPSIDEIPNIVNPSMHGMVEVMRGCGRGCKFCDVTLRPLRYYPVEKVQKEIEINMKYGGLKNAWIHSDDIFVYGLNPRTTKNMQPNREAIEELFKGIMATGVEHTNPTHGTLAGAIADERLLPNVSKIIRSGPNNHIGIQCGFETGSIRLIGKYADRKLAPYKPEEWHWVVKTGVKALNEHYWVPAFTLIMGLDNDETPDDSWETIRLIHELETEQPDSKFTVTPLTFVPIGLLEKSDFYDIGNTMDPAKLGVMYKTWQHNFKHGIQKFMGKVGRDNPVKNMFFTALASSLGGVPLTAMEKYARRKGPEHERVIEKIKASYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQ63</accession>
    <name>A0A075MQ63_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Proline--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Prolyl-tRNA synthetase</fullName>
            <shortName evidence="8">ProRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">proS</name>
        <name evidence="10" type="ORF">NTE_01640</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>tRNA(Pro) + L-proline + ATP = L-prolyl-tRNA(Pro) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="8"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700425.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQ63"/>
    <dbReference type="STRING" id="1459636.NTE_01640"/>
    <dbReference type="GeneID" id="41597416"/>
    <dbReference type="KEGG" id="nev:NTE_01640"/>
    <dbReference type="eggNOG" id="arCOG00402">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001882_4_2_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00862">
        <property type="entry name" value="ProRS_anticodon_zinc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00778">
        <property type="entry name" value="ProRS_core_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000005">
        <property type="entry name" value="bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000037">
        <property type="entry name" value="Proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.30">
        <property type="entry name" value="C-terminal domain of ProRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01571">
        <property type="entry name" value="Pro_tRNA_synth_type3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004499">
        <property type="entry name" value="Pro-tRNA-ligase_IIa_arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016061">
        <property type="entry name" value="Pro-tRNA_ligase_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017449">
        <property type="entry name" value="Pro-tRNA_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033721">
        <property type="entry name" value="ProRS_core_arch_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00408">
        <property type="entry name" value="proS_fam_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382:SF2">
        <property type="entry name" value="BIFUNCTIONAL GLUTAMATE_PROLINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382">
        <property type="entry name" value="PROLYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09180">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SMART" id="SM00946">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64586">
        <property type="entry name" value="C-terminal domain of ProRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 8 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="9">
        <location>
            <begin position="41"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00060806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIF83701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="486" mass="54790" checksum="BB968AF959662FD8" modified="2014-10-29" version="1">MSSQPPKEAVGITAKKSDDFSEWYTQVVMKAGLADYAPVKGFIVLRPYGYAVWESIRDILDRRFKETGHQNGFLPVLIPEGLLSKEEDHFAGFTPEVFWVTQAGNNDLGERLALRPTSETLAYSIFAKWITSYRDLPLKINFWNTALRAEIKATKPFIRTSEFLWQEGHTVHATEDDAEQEVMSILSIYRELIEDHLAVPAVRGFKSDKEKFVGAKYTTTLEGMMADGKALQMGTSHHLAQNFSKPFEIKYLGKDTKEHLAWQTSWGVSWRLIGAIIMVHGDDKGLILPPKIAPIQVVIVPIHKDKDAQAVKEKANEIAQELKNAGIRVHVDDRDEYTSGWKFNEWELKGVPLRINIGARDIEKGQVEFARRDIRDNKIQSPRTSLVDKTNELLEEVQKSLFSKAKALLDGYISSPASYPEFRSIIEGKGGFARAGWCGDQKCELAVKEETGADIRVIPFDQDGMPEKCIYCGQAAKKVAMFGRAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQ88</accession>
    <name>A0A075MQ88_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Leucine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Leucyl-tRNA synthetase</fullName>
            <shortName evidence="8">LeuRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">leuS</name>
        <name evidence="11" type="ORF">NTE_01284</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>tRNA(Leu) + L-leucine + ATP = L-leucyl-tRNA(Leu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="8"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700138.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQ88"/>
    <dbReference type="STRING" id="1459636.NTE_01284"/>
    <dbReference type="GeneID" id="41597087"/>
    <dbReference type="KEGG" id="nev:NTE_01284"/>
    <dbReference type="eggNOG" id="arCOG00809">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004174_0_0_2"/>
    <dbReference type="OrthoDB" id="23906at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2320.20">
        <property type="entry name" value="Class I aminoacyl-tRNA synthetases (RS)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.720">
        <property type="entry name" value="leucyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00049_A">
        <property type="entry name" value="Leu_tRNA_synth_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020791">
        <property type="entry name" value="Leu-tRNA-lgase_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004493">
        <property type="entry name" value="Leu-tRNA-synth_Ia_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00395">
        <property type="entry name" value="leuS_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008957">
        <property type="entry name" value="PRK12300.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45794:SF1">
        <property type="entry name" value="LEUCINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45794">
        <property type="entry name" value="LEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="9">
        <location>
            <begin position="14"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="10">
        <location>
            <begin position="703"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="8">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="629"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="632"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIF83353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="966" mass="109141" checksum="6EEDB548DEF2512D" modified="2014-10-29" version="1">MSSNNIDWREIEEKWIKRWDEQKLFQADPEPSRKKYFVTVAYPYPNSPQHIGHGRTYTLADAHARYMRMKGYNVLFPMGFHYTGTPILGMSRRVAAGDKDLLDTFHNIYKLTDDVIATFVEPVKIASYFHNEIKQGMKEMGYSMDWRREFTTIDRIYSKFISWQFRTLQKKGLIVQGSHPVGWCPNDQNPVSQHDTMGDVEPDFTEYVLVKFVAQNDGLVVPAATLRPETLFGVTNMWVDPEVEYVEARVDGERWIVSKEAARKLEFLNHAIEIIKTIKGSEMVGWQLTNPLNGAKVPMYPASFVEADSGTGIVMSVPAHAPYDYQALADLKNDAAMRQKYDIATVAEPVKIIESEGYSGIPAAEAIANVPANSSDRLEKATSDLYSHEFYKGRMMQNTGKYAGKPVSAAKEELKAEIASSGLTSVMYELTNKPVICRCGTECVVKLLNDQWFLNYADKEWKALAHECIQKMDIVPADIRQEFDYVVDWLRERACARKSGLGTKLPWDPEWIIESLSDSVIYMAYYTIAKYVNDKTIPDTETISDSFFDYVLFGQGDAKAVAKESGVPAIEKIRAEFQYFYPVDSRHSGRDLVPNHLSFFIFNHVAIFDRSNWPRQIVVNGSVLMEGKKMSKSLGNIIPLRAAIREHGADTIRLAMLVSAEILQDADFSFDTARGIKSKLAGVFEMAEKVKNAKQAPAEQVEDRWLASRLVRTALQTAESMDRLRVREAIHHILYTLEQDLQWYDRRARAKGRENSPAVVSALREYVKAQVQMLAPFAPFTAEEVWERLGSKETITAAGWPSTDESKLDILAEESEFLAQSLIADIANIVKVTKIAPKKIVVYTGAGWKNNAYKTVLENIAAGRTNFGDMMKQLIANPETSRIKSDPNLVKKMQDDILSTPLEARSRRTALTDFDEASAIKDAAGLIAKEFDGAEVLVYSEDDHSKYDPKGKAKFARSFKPAVYME</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQA6</accession>
    <name>A0A075MQA6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein required for cytochrome oxidase assembly</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">NTE_00992</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SR1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="11">Porphyrin-containing compound metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699906.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQA6"/>
    <dbReference type="STRING" id="1459636.NTE_00992"/>
    <dbReference type="GeneID" id="41596820"/>
    <dbReference type="KEGG" id="nev:NTE_00992"/>
    <dbReference type="eggNOG" id="arCOG03103">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1860763_0_0_2"/>
    <dbReference type="OrthoDB" id="336837at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006784">
        <property type="term" value="P:heme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003780">
        <property type="entry name" value="COX15/CtaA_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050450">
        <property type="entry name" value="COX15/CtaA_HemeA_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35457">
        <property type="entry name" value="HEME A SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35457:SF1">
        <property type="entry name" value="HEME A SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02628">
        <property type="entry name" value="COX15-CtaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIF83067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="157" mass="16601" checksum="1F6C9A5FC2D45A76" modified="2014-10-29" version="1">MTLLQKLSFGTLAVLFSLIFIGGYVSSSGVGLTCPDWPLCPHGFVPAYDFIIEYIHRTVAASTGALVVITMAFTLKSKQAPRGMKIASIIAAGAVIGQITLGAIVIVERLHSILVTGHLALGLVLFSMVLMTTVYAWKIKAQNKAAVEASGRQQPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQC8</accession>
    <name>A0A075MQC8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glutamate-1-semialdehyde 2,1-aminomutase</fullName>
            <shortName evidence="8">GSA</shortName>
            <ecNumber evidence="8">5.4.3.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glutamate-1-semialdehyde aminotransferase</fullName>
            <shortName evidence="8">GSA-AT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hemL</name>
        <name evidence="10" type="ORF">NTE_01013</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(S)-4-amino-5-oxopentanoate = 5-aminolevulinate</text>
            <dbReference type="Rhea" id="RHEA:14265"/>
            <dbReference type="ChEBI" id="CHEBI:57501"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="5.4.3.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.3.8" evidence="8"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQC8"/>
    <dbReference type="STRING" id="1459636.NTE_01013"/>
    <dbReference type="KEGG" id="nev:NTE_01013"/>
    <dbReference type="eggNOG" id="arCOG00918">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_1_5_2"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00317"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042286">
        <property type="term" value="F:glutamate-1-semialdehyde 2,1-aminomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000021">
        <property type="entry name" value="Glutamate-1-semialdehyde 2,1-aminomutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00375">
        <property type="entry name" value="HemL_aminotrans_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004639">
        <property type="entry name" value="4pyrrol_synth_GluAld_NH2Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000818">
        <property type="entry name" value="PRK00062.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43713">
        <property type="entry name" value="GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43713:SF3">
        <property type="entry name" value="GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE 1, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 8" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="5 8 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIF83087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="431" mass="46637" checksum="664F9F98DE4A266B" modified="2014-10-29" version="1">MVASSRSEQLYNRAKKVLPGGVDSPVRFFEPYPFFAASARGSKLVTSDHKTLTDYCMGYGAMLLGHGYPSVLDAARSQLDIGTLYCVPTELEIKLAELISKAVPCADMVRLVNTGSEATMNAIRLARAFAKKKKVIKFDGGYHGAHDYVLAKAGSGAASLPASEGILEEASAQTVVAPYNDAAELERTIERNRDDAACVIMEPVLANIGLVLPDKNYLSDVRKITQQNDVVLIFDEVVTGFRLALGGAGEFFGIKPDIATFAKALGNGFPIGAIAGRKEIMQQLAPAGKVYQASTFAGNPVSVSAAIAALSTLFEAKDSIYPQVARTCDSIVEGIEEELEDIGGVNCTINSIGSMYQVFFTADKVRDDASAKRADSAKFKRLFDELLKRNVFIPPSQFETCFVSYAHDEDDVDRTVDAYSEAFKKIKELQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQD6</accession>
    <name>A0A075MQD6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endoribonuclease Nob1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NTE_01350</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Toxic component of a type II toxin-antitoxin (TA) system. Processes pre-16S-rRNA at its 3' end (the D-site) to yield the mature 3' end.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NOB1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385171.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQD6"/>
    <dbReference type="STRING" id="1459636.NTE_01350"/>
    <dbReference type="GeneID" id="41597148"/>
    <dbReference type="KEGG" id="nev:NTE_01350"/>
    <dbReference type="eggNOG" id="arCOG00721">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109674_0_1_2"/>
    <dbReference type="OrthoDB" id="27944at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09876">
        <property type="entry name" value="PIN_Nob1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000020">
        <property type="entry name" value="20S-pre-rRNA D-site endonuclease NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039907">
        <property type="entry name" value="NOB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033411">
        <property type="entry name" value="Ribonuclease_PIN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12814">
        <property type="entry name" value="RNA-BINDING PROTEIN NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12814:SF2">
        <property type="entry name" value="RNA-BINDING PROTEIN NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17146">
        <property type="entry name" value="PIN_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="domain" description="Ribonuclease PIN" evidence="8">
        <location>
            <begin position="8"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF83418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="164" mass="17196" checksum="964EDBD759FECD9F" modified="2014-10-29" version="1">MGSREELALDASAFYAGIAFLSGAKCVTTSAVFDEIKHVKAAALDALVHAGNLQVLDPDRKSIDAVAAAAKKTGDLAKLSAADVSILALALERKATLASDDYAVANVAATLEIKTVASSGKGIRETRRYIAYCSACGKAFSPEKLECPLCGNKLKRRYKKISTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQE0</accession>
    <name>A0A075MQE0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NTE_01355</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987200.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQE0"/>
    <dbReference type="STRING" id="1459636.NTE_01355"/>
    <dbReference type="GeneID" id="41597153"/>
    <dbReference type="KEGG" id="nev:NTE_01355"/>
    <dbReference type="eggNOG" id="arCOG01389">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012856_4_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000057">
        <property type="entry name" value="Glycosyltransferase-like protein, family 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32044">
        <property type="entry name" value="GLUCOMANNAN 4-BETA-MANNOSYLTRANSFERASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32044:SF80">
        <property type="entry name" value="XYLOGLUCAN GLYCOSYLTRANSFERASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13641">
        <property type="entry name" value="Glyco_tranf_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="321"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="351"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="441"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="466"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="522"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="655"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIF83423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="690" mass="78138" checksum="5BA4FC3EB3AD9B01" modified="2014-10-29" version="1">MVMYGPGSFLYVIFLVITWVTMFYSLNFYYLAIQSRHNESHERRKRQVPELPATLLPTVTIQLPLYNEKYVARRLIDAVCKMDYPKNKMQIQVLDDSDDDTVDLIRSIVDEYRFKGFDIVHVRRGDRSGYKAGALKAGMKTAKGEFIAIFDADFIPPSSFLKHLLRYFSDPKMGFVQCKWGHVNEDYSSMTQAQAVSLDLHFLVEQKAKSLSRIFLNFNGTAGIWRTSCINDAGGWQTTTLVEDMDLSYRAQMKGWKCMFLDDYVVNAELPVQMNAAKRQQFRWAKGSIQVALKLLTDVIAHRKVPVESKVQSFIHMTRHVAHPFFLAQFLIFPMLLSMDYKLYESNWAPLFVLAMYAALGPGGYLVVINKVWKKGWKHKAMQFMFLHFFGAGISVNNSVAVFDALFGRKSEFLRTPKFGIVKKGEEWRNKEYALPFTKTTLLEIFFALYGCISIFVAIFSNNALFTPLIALPTIGFIYVAYLSIAHSQLGKRKKKTTTATIAAGQALAPVQNSGRTLGQRLLLPSVLAFLILGAGVAYYGYHTSIYPLQEASGFLARAQTAQTPQQLADYARLAQKFIPESGNPVWLFPTFRTDFEIMHMQLDSMVERSEIISSLSTHDEGYNAALIDMHSTALEMQASLHEAIPYIYVSPQNIALGAAWIGIILSVFAAMKRARTRHQRAETASAVQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQG4</accession>
    <name>A0A075MQG4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01044</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQG4"/>
    <dbReference type="STRING" id="1459636.NTE_01044"/>
    <dbReference type="KEGG" id="nev:NTE_01044"/>
    <dbReference type="HOGENOM" id="CLU_2475836_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="87" mass="9251" checksum="EAA36AC4E958243C" modified="2014-10-29" version="1">MGTVALDLGKGGEGKEEEGLSGVIVKCPVCAGSGSIQCIKNNRVNPLCLSLPLAVEERCNCCDGRGWVRKEQQECSSFCSSVTREKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQP1</accession>
    <name>A0A075MQP1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LAO/AO transport system ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NTE_01109</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQP1"/>
    <dbReference type="STRING" id="1459636.NTE_01109"/>
    <dbReference type="KEGG" id="nev:NTE_01109"/>
    <dbReference type="eggNOG" id="arCOG01226">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043725_1_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052040">
        <property type="entry name" value="GTPase/Isobutyryl-CoA_mutase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005129">
        <property type="entry name" value="GTPase_ArgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00750">
        <property type="entry name" value="lao"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43087:SF1">
        <property type="entry name" value="LAO_AO TRANSPORT SYSTEM ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43087">
        <property type="entry name" value="LYSINE/ARGININE/ORNITHINE TRANSPORT SYSTEM KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03308">
        <property type="entry name" value="MeaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF83182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="309" mass="33368" checksum="718447D4082517C9" modified="2014-10-29" version="1">MPVLPIVKGLVQGDRRSLARAISIVDNQEPESRQIIKEIFEKTGKARTVGFTGPGGAGKSSLVGRLIPECQALGHKVAVLAVDPTSPITGGAILGDRVRMLGSLDDEKVFMRSMASRGAVGGVSKSLRNAIRVLDAAGYDLILVESVGAGQLEIEITKVVDLTVVLFTPNTGDNVQAVKAGLTEVGDIYVVNKADIDGAGPLYNILVDMIGDTERRPPILKTSAKTGKGVRELAQHIDKLLKERSINYKVRERKMLEDELKDMVSDIVSQKVASMLKENKKYSAFIDKLARKEIDPYMAADKVAASLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQV2</accession>
    <name>A0A075MQV2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">IPT/TIG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01866</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQV2"/>
    <dbReference type="KEGG" id="nev:NTE_01866"/>
    <dbReference type="HOGENOM" id="CLU_1222475_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3920">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="226" mass="22556" checksum="9CFAF0FA53B5D8FB" modified="2014-10-29" version="1">MDEEKSRKNYSLQPLRKKTLTALIVGLAILSSLSVTVIMADSATAQKDQAVNQTSTASGNATAAASEAVRNATTSAQNAGEAARNATASAGNAIANATKAGAGMIGAAITNATSSLNKTISNPSSITVTPDSVNPGDIVVVKGAGFSANQTITLTFDNSSNATTAKADKSGAFNATMTTPNDAKNGTHNITATDREGKSATATITIAAAPKANSSSSALSSFRPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRI4</accession>
    <name>A0A075MRI4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NTE_01354</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRI4"/>
    <dbReference type="STRING" id="1459636.NTE_01354"/>
    <dbReference type="KEGG" id="nev:NTE_01354"/>
    <dbReference type="eggNOG" id="arCOG04548">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_881675_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050572">
        <property type="entry name" value="Fe-S_Ferredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43687">
        <property type="entry name" value="ADENYLYLSULFATE REDUCTASE, BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43687:SF6">
        <property type="entry name" value="L-ASPARTATE SEMIALDEHYDE SULFURTRANSFERASE IRON-SULFUR SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="9">
        <location>
            <begin position="256"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="9">
        <location>
            <begin position="293"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="162"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIF83422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="325" mass="35245" checksum="9AC08144F29EA4C0" modified="2014-10-29" version="1">MLSETAKRGVYPLHGSKLGIYRIPVEITDKADIASIQNDLRPAGFTMQTHADRIYVTYKWTEKGVDPVTGEDLSADLNITVEIVTGEVVDLIYQIRQIEYFGDPYWIKNYRATADKNAKMVIDTIIRNTKIGDKMIAQYQKAEKLTLEQAIKKLEELTPLAKNPKARSATAPPPPTAASAAPKPAATPAMAAPQAPAAGGSGDTTVSLAGTGTNYSKVEGPIDVKFKEKRQQVGKFQGIAVWGPLDAPGQLGIWGTNVCVDFDICVADGACIEACPVNVYEWLETPGHPASEKKAFMAREKDCIFCLACENVCPPQAIKIFQKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRP5</accession>
    <name>A0A075MRP5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01689</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRP5"/>
    <dbReference type="KEGG" id="nev:NTE_01689"/>
    <dbReference type="HOGENOM" id="CLU_214147_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="52" mass="6236" checksum="80F69F1E39E02DB1" modified="2014-10-29" version="1">MFGFGIILTALADRLAQRRNKERKRCDICRQRFDTYEAAEEHRRKVHADVMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRT6</accession>
    <name>A0A075MRT6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01817</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700573.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRT6"/>
    <dbReference type="STRING" id="1459636.NTE_01817"/>
    <dbReference type="GeneID" id="41597582"/>
    <dbReference type="KEGG" id="nev:NTE_01817"/>
    <dbReference type="eggNOG" id="arCOG11395">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_145812_0_0_2"/>
    <dbReference type="OrthoDB" id="6423at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="120" mass="14018" checksum="78E6D22E6490C663" modified="2014-10-29" version="1">MSYDRFVDERVLTSRDALNRFQIKIKLVEIDEGARDFSRRFGNRILVRKILLTIKHTETQEVEERELNVEEVEKRMKKERLFSSTNRWVASTDIKNGYVVASKHLDLLADAIALDIVPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRT8</accession>
    <name>A0A075MRT8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Bifunctional protein FolD</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="12">Methylenetetrahydrofolate dehydrogenase</fullName>
                <ecNumber evidence="12">1.5.1.5</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="12">Methenyltetrahydrofolate cyclohydrolase</fullName>
                <ecNumber evidence="12">3.5.4.9</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="12" type="primary">folD</name>
        <name evidence="15" type="ORF">NTE_02167</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(6R)-5,10-methenyltetrahydrofolate + H2O = (6R)-10-formyltetrahydrofolate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="EC" id="3.5.4.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) = (6R)-5,10-methenyltetrahydrofolate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:22812"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 12">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.5" evidence="12"/>
    <dbReference type="EC" id="3.5.4.9" evidence="12"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700834.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRT8"/>
    <dbReference type="STRING" id="1459636.NTE_02167"/>
    <dbReference type="GeneID" id="41597891"/>
    <dbReference type="KEGG" id="nev:NTE_02167"/>
    <dbReference type="eggNOG" id="arCOG04538">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034045_2_1_2"/>
    <dbReference type="OrthoDB" id="9455at2157"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004477">
        <property type="term" value="F:methenyltetrahydrofolate cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01080">
        <property type="entry name" value="NAD_bind_m-THF_DH_Cyclohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000094">
        <property type="entry name" value="Bifunctional protein FolD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10860:FF:000005">
        <property type="entry name" value="C-1-tetrahydrofolate synthase, cytoplasmic, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01576">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020867">
        <property type="entry name" value="THF_DH/CycHdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099:SF5">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00766">
        <property type="entry name" value="THF_DHG_CYH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00767">
        <property type="entry name" value="THF_DHG_CYH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="6 12 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 12" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7 12" id="KW-0521">NADP</keyword>
    <keyword evidence="3 12" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="8 12 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 12" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic" evidence="13">
        <location>
            <begin position="6"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding" evidence="14">
        <location>
            <begin position="139"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="165"/>
            <end position="167"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AIF84221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="284" mass="30666" checksum="27F1260BD747171A" modified="2014-10-29" version="1">MVAQIISGLTVAQDVKERVKKAVEELKTSGIIPCLATVLVGDDPASATYVNSKQKTAKELGIATRDHRLAATFKQHELLELVQLLNNDPEVHGILVQLPLPKHIDEFAIINTISPLKDVDGLTPYSAGMLQNGMALLKPCTPSGVMELLDYYKIALEGKDVVIINRSNLVGKPLVFMLLERNATVTVCHSKTRDLPARLRQADIIITAVGNRERFTLKADMVKEGAVVIDVATSRINGKLAGDADFEAVKQKASWITPVPGGVGPMTIAMLMKNTVTAASILRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRW5</accession>
    <name>A0A075MRW5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01779</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRW5"/>
    <dbReference type="STRING" id="1459636.NTE_01779"/>
    <dbReference type="KEGG" id="nev:NTE_01779"/>
    <dbReference type="HOGENOM" id="CLU_3056950_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="53" mass="5846" checksum="9DBCC53970FA663D" modified="2014-10-29" version="1">MAATLQHREHGIVEMGCVLAEMHRSPFGRDLLHNAMAEMGLTCDMCDEQEGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRZ2</accession>
    <name>A0A075MRZ2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Adenosylmethionine-8-amino-7-oxononanoate aminotransferase</fullName>
            <ecNumber evidence="7">2.6.1.62</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">7,8-diamino-pelargonic acid aminotransferase</fullName>
            <shortName evidence="7">DAPA AT</shortName>
            <shortName evidence="7">DAPA aminotransferase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">7,8-diaminononanoate synthase</fullName>
            <shortName evidence="7">DANS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Diaminopelargonic acid synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">bioA</name>
        <name evidence="9" type="ORF">NTE_01809</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(8S)-8-amino-7-oxononanoate + S-adenosyl-L-methionine = S-adenosyl-4-methylsulfanyl-2-oxobutanoate + (7R,8S)-7,8-diammoniononanoate</text>
            <dbReference type="Rhea" id="RHEA:16861"/>
            <dbReference type="ChEBI" id="CHEBI:16490"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:149468"/>
            <dbReference type="ChEBI" id="CHEBI:149469"/>
            <dbReference type="EC" id="2.6.1.62"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cofactor biosynthesis; biotin biosynthesis; 7,8-diaminononanoate from 8-amino-7-oxononanoate (SAM route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.62" evidence="7"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700565.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRZ2"/>
    <dbReference type="STRING" id="1459636.NTE_01809"/>
    <dbReference type="GeneID" id="41597574"/>
    <dbReference type="KEGG" id="nev:NTE_01809"/>
    <dbReference type="eggNOG" id="arCOG00917">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_4_3_2"/>
    <dbReference type="OrthoDB" id="6534at2157"/>
    <dbReference type="UniPathway" id="UPA00078">
        <property type="reaction ID" value="UER00160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004015">
        <property type="term" value="F:adenosylmethionine-8-amino-7-oxononanoate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00834">
        <property type="entry name" value="BioA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005815">
        <property type="entry name" value="BioA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00508">
        <property type="entry name" value="bioA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42684">
        <property type="entry name" value="ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42684:SF3">
        <property type="entry name" value="ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 9" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5 7" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 7 9" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="115"/>
            <end position="116"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="318"/>
            <end position="319"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="412"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM" evidence="7">
        <location>
            <position position="19"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF83870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="448" mass="50531" checksum="6586C2656CB53871" modified="2014-10-29" version="1">MSGSPSLKDADRNFVWHPYTQMKDWEKQDNRVIVNGEGFYLVDDRGRRYLDGTASMWCNVWGHGQNEVVEAMREQLKHLQHSTLFGLASEPSARLAERLVKMAGGMDRVFYTDNGSTAIEAALKMALQYWQNRGKSEKKLFVSLEGGYHGDTVGAMSVGYIEQFFGAYKPLLAKVSRVPSPLLYGSKFDSEQDLVEHCIEQTEKTLKKLDGKCAGLVMESGAQIAGGVVVYPQKYQQKISELCEKYDTLLILDEIATGFGRLGNMIEYRAQKSKPDIVCMGKALTAGYFPLAVTLAHEKIYDAFLGSYEKNKHFYHGHTFTGHPVGCAAALANLELYEKRNLMQQIKENTQYIKQRLREFEEIGIVADVRHKGMLAGIELARNGRPLVHLKNKERINYFVARESLEMGVHLRALGNIMVVIPPLAIGRNDLKKMMDAHQELVKKAEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MS22</accession>
    <name>A0A075MS22_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01904</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226986921.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MS22"/>
    <dbReference type="GeneID" id="41597654"/>
    <dbReference type="KEGG" id="nev:NTE_01904"/>
    <dbReference type="eggNOG" id="arCOG08653">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1682757_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="165" mass="17567" checksum="D9D8B2A2517A9517" modified="2014-10-29" version="1">MNSFSIVFSSKAHIALAIAVAAGFWVLMAHFDQLLFFSPILAFDVPPSGWAGFALSTITAVMLGIVVSMNVYIFRTSEVRIGASFFSGSTLGVISSACAGCTSAGFFMASTFGVAGAAATSIFVQYQLPLRIVSIGLLAWALYSVNRRVTRSCAIKPSNNMEEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MS58</accession>
    <name>A0A075MS58_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01939</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MS58"/>
    <dbReference type="KEGG" id="nev:NTE_01939"/>
    <dbReference type="HOGENOM" id="CLU_2284914_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="101" mass="11746" checksum="3A61C7FFCAE6873D" modified="2014-10-29" version="1">MKCNKCTGHRSNGIAEFVFRCHVRGSKMHARYLAIRCNPEIEVKISLVCVGEFDELHFKHTFITAHNAQSGARGEQFYQECIEIIRLRTDVYNDFRSPIQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MS59</accession>
    <name>A0A075MS59_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Bacterial Pleckstrin homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700957.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MS59"/>
    <dbReference type="STRING" id="1459636.NTE_02323"/>
    <dbReference type="GeneID" id="41598039"/>
    <dbReference type="KEGG" id="nev:NTE_02323"/>
    <dbReference type="HOGENOM" id="CLU_147945_1_0_2"/>
    <dbReference type="OrthoDB" id="378737at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027783">
        <property type="entry name" value="Bacterial_PH-related"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10882">
        <property type="entry name" value="bPH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bacterial Pleckstrin homology" evidence="1">
        <location>
            <begin position="27"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="117" mass="13001" checksum="F59E6967AB4A7F86" modified="2014-10-29" version="1">MVSVTVRVEEDMLVIEPAGRLSKFASLARNVEVPLACIKEVSIERAEIKGLKTGGTALPPHFAGRFYDFKTGRIFYALSDRDKCVTLRLEGAKYDEIIVQVDDKERVAEMVKRAVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSC2</accession>
    <name>A0A075MSC2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_01641</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700426.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSC2"/>
    <dbReference type="STRING" id="1459636.NTE_01641"/>
    <dbReference type="GeneID" id="41597417"/>
    <dbReference type="KEGG" id="nev:NTE_01641"/>
    <dbReference type="eggNOG" id="arCOG03119">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101250_0_0_2"/>
    <dbReference type="OrthoDB" id="10722at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051311">
        <property type="entry name" value="DedA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="VTT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42709">
        <property type="entry name" value="ALKALINE PHOSPHATASE LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42709:SF10">
        <property type="entry name" value="SNARE ASSOCIATED GOLGI PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="VTT_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="VTT" evidence="2">
        <location>
            <begin position="41"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF83702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="225" mass="24903" checksum="07FE15213C632AB8" modified="2014-10-29" version="1">MVDITDLLFPLDGELGYLGIFLVSFVGSIIVFVPVPYFPIILAAALSDKFDPHMIAIVSALGTVIAKTIIFFASYYGRKMLSQQTQKRMLPLQRLVSKYGWPGAFVAAATPVPDDIVYIPLGLARYSPWKFALSTFAGKVVMNEAIVWSTVFLGRPLVQDVVSGTDNTTLAIITVASIAAMGLIIYYSLKIDWGKLIGRWFPWAVKEDDEEEKEKTKDGAEKKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSC5</accession>
    <name>A0A075MSC5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00172</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSC5"/>
    <dbReference type="STRING" id="1459636.NTE_00172"/>
    <dbReference type="KEGG" id="nev:NTE_00172"/>
    <dbReference type="HOGENOM" id="CLU_1773261_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="159" mass="18213" checksum="1D984B3CB486EFF1" modified="2014-10-29" version="1">MPLSMQIEESLIQKYYLAERCFVRPEVRISNYVLKWNEISYGIPKREVSELKAFLKEILPYISGAFFKAAGQISKTIEEEVGDARQVRKIHDSFLPELQISSRRVDHEYVLQMREDGATVISRNETVTTSSGDGHDRSSSRIMANLSINSILGELVFIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSD8</accession>
    <name>A0A075MSD8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01651</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSD8"/>
    <dbReference type="STRING" id="1459636.NTE_01651"/>
    <dbReference type="KEGG" id="nev:NTE_01651"/>
    <dbReference type="eggNOG" id="arCOG08668">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2550393_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="95" mass="10989" checksum="0EE254DEC882F39A" modified="2014-10-29" version="1">MNKYGLSQLTLVVPDNNSSDDDYPVVINEDGIKIKTERMEQEKLYHCVFEDKVYLFYKDELGLLHCYEVENPEAVKEITKNPGDIENILKKHAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSF1</accession>
    <name>A0A075MSF1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987294.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSF1"/>
    <dbReference type="GeneID" id="99755922"/>
    <dbReference type="KEGG" id="nev:NTE_00192"/>
    <dbReference type="eggNOG" id="arCOG01055">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_159725_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038723">
        <property type="entry name" value="ArnR1-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14947">
        <property type="entry name" value="HTH_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ArnR1-like winged helix-turn-helix" evidence="1">
        <location>
            <begin position="9"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="84" mass="9747" checksum="B975772DBAF68F5B" modified="2014-10-29" version="1">MDIIQKDSLAHAEGDGVLKTTIMYNCYVSIPQLRKYMPLLQEHGLIEYSEKTRLYRTTEKGSLYRKAYDAVADALKPNNKRSRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSG3</accession>
    <name>A0A075MSG3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02472</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701080.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSG3"/>
    <dbReference type="GeneID" id="41598177"/>
    <dbReference type="KEGG" id="nev:NTE_02472"/>
    <dbReference type="HOGENOM" id="CLU_157324_0_0_2"/>
    <dbReference type="OrthoDB" id="7509at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="98" mass="10807" checksum="B3EF5613EF585EA5" modified="2014-10-29" version="1">MRFVIRAIIPTETGNKMVKDPNFISNMENYIKANKAEAAYFLELNGDRTAVFVLDLPSVDMIPAVAEPLFMLGAKVELHPAMTIDDLKKGIALAIGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSG5</accession>
    <name>A0A075MSG5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phasin protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01671</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700450.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSG5"/>
    <dbReference type="GeneID" id="41597445"/>
    <dbReference type="KEGG" id="nev:NTE_01671"/>
    <dbReference type="HOGENOM" id="CLU_113181_0_0_2"/>
    <dbReference type="OrthoDB" id="10637at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="192" mass="21786" checksum="B856BEF2232493B0" modified="2014-10-29" version="1">MASRKDDKKESTPAKPESGGEAPRSFEDMERQQREAISRSLDESKENLRKTLNEAEQEIPKYTQVLRDYQTKSIDASRDIAESYLDSQKQAINSMQSTWSQNVRQMESWWGFPMSPQAAAELFSRMATTIADATIAASKTANKMMFANMEAAAITMNQIRESAKEMARINANLFATMGRTSRETAERSRMTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSG8</accession>
    <name>A0A075MSG8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Guanosine polyphosphate synthetase/pyrophosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02477</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701085.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSG8"/>
    <dbReference type="STRING" id="1459636.NTE_02477"/>
    <dbReference type="GeneID" id="41598182"/>
    <dbReference type="KEGG" id="nev:NTE_02477"/>
    <dbReference type="eggNOG" id="arCOG06870">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1197666_0_0_2"/>
    <dbReference type="OrthoDB" id="8597at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13328">
        <property type="entry name" value="HD_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="232" mass="26635" checksum="83D4CBC6FADCCD08" modified="2014-10-29" version="1">MAQTTTRASKSEFLSFLENEGRIRPDSLIEGAIEVAEEVHAGLVREDGKSLFLETHTWPVAMDVVAHYRANNRNITGVEVASAILHDVMEDDERILNLYESKSYGFEAYLAYRFGSKVQRIASDLKIKPIEMFPGQTDDERKAARFWDYCGILAKADYDVKVIKLADRLNNMAFVYYSLPGHEKQKRYMREAEDFYLAYAMIAPSMPQFYARLRKMYEALRSSQKQVAATTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSR3</accession>
    <name>A0A075MSR3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSR3"/>
    <dbReference type="STRING" id="1459636.NTE_02130"/>
    <dbReference type="KEGG" id="nev:NTE_02130"/>
    <dbReference type="HOGENOM" id="CLU_181205_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="94" mass="10851" checksum="ADA408125348AD97" modified="2014-10-29" version="1">MLWVENGLIQKLIEAHAVEKYQTDIAFTKTFQRFVARQRAKITKEQTLEDWRLILGAYDYKLVNLTADEAGATMVLLEFFADNTKKKTAIPDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSU7</accession>
    <name>A0A075MSU7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02166</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700833.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSU7"/>
    <dbReference type="STRING" id="1459636.NTE_02166"/>
    <dbReference type="GeneID" id="41597890"/>
    <dbReference type="KEGG" id="nev:NTE_02166"/>
    <dbReference type="eggNOG" id="arCOG11431">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1709039_0_0_2"/>
    <dbReference type="OrthoDB" id="8570at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="153" mass="18051" checksum="AF556E6CC036BA9D" modified="2014-10-29" version="1">MNAKFFQRRWLDFRNGHSIYLVFTMAFLQFVITTYTLGIERFDVLKTVFPSMGTWAIIFVAIYVPAAVAIGYWHRRNQYSVENEALLKENWVWAWIMMYEIRLIEGKATPEETRQVKEFLEGVLKRQKKDALMSHYIEDILKREAPPSSSSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSW9</accession>
    <name>A0A075MSW9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Formyltetrahydrofolate hydrolase</fullName>
            <ecNumber evidence="4">3.5.1.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_02159</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.1.10" evidence="4"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700828.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSW9"/>
    <dbReference type="STRING" id="1459636.NTE_02159"/>
    <dbReference type="GeneID" id="41597883"/>
    <dbReference type="KEGG" id="nev:NTE_02159"/>
    <dbReference type="eggNOG" id="arCOG02826">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038395_3_0_2"/>
    <dbReference type="OrthoDB" id="27277at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008864">
        <property type="term" value="F:formyltetrahydrofolate deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.170">
        <property type="entry name" value="Formyl transferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004810">
        <property type="entry name" value="PurU"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004684">
        <property type="entry name" value="PRK06027.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42706">
        <property type="entry name" value="FORMYLTETRAHYDROFOLATE DEFORMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42706:SF1">
        <property type="entry name" value="FORMYLTETRAHYDROFOLATE DEFORMYLASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13740">
        <property type="entry name" value="ACT_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036480">
        <property type="entry name" value="FormyFH4_hydr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01575">
        <property type="entry name" value="FFH4HYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="Formyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="3">
        <location>
            <begin position="17"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF84213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="303" mass="33729" checksum="741604F0973896A8" modified="2014-10-29" version="1">MVAASSSSAAGNKTIIEVTVVGKDRKGVVADITNFIFQNGGNIEKINQNVVRGLFGMQLEASFARAKRKELDDGLKDLAKRLQMEIKVHYQEPDRLRNVAILVSKEPHCINRILAGRKKGEIKANLAVVIGSEPSLKPVADEAGIPFHSVSHTDQAEAERNILDLIEKYNVDLIVLARYMRILTPNFVWRYPNRIINIHPSLLPAFPGAYAYVQAYERGAKIVGCTAHFVTEDLDQGPIICQESFKVSDSDTLETIRKKGRELEAATLFEAVRLYLEDRLEVYWGKVLVHKSPKGKATTTTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSY0</accession>
    <name>A0A075MSY0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase propeptide domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00362</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSY0"/>
    <dbReference type="STRING" id="1459636.NTE_00362"/>
    <dbReference type="KEGG" id="nev:NTE_00362"/>
    <dbReference type="HOGENOM" id="CLU_102442_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025711">
        <property type="entry name" value="PepSY"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03413">
        <property type="entry name" value="PepSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PepSY" evidence="1">
        <location>
            <begin position="95"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="248" mass="25663" checksum="CEEA5EEE5923D10A" modified="2014-10-29" version="1">MSTRTRGNNNRSFLIPAALSLAASLLTMTWTTIIMPSLAFAQTSTNSGGDGAITQSNSSSNNTHAEGGPIAAGRINLKQAAVDFINGNLNATLFDAAEAAERQVQNSTVIAGRLDAVEGYLAYNITVADTDNNVTYRVYVDPSDGKIVSTSVGRPVSALGIPPSFEDLNATMIDAADVAENQIENSTAIAGSFAVTQGNALVYSVMVADLDKGLIYKVDIDAATGNAASISKGMPIGDLGIEGVFGHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MT02</accession>
    <name>A0A075MT02_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sulfate adenylyltransferase</fullName>
            <ecNumber evidence="7">2.7.7.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">ATP-sulfurylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Sulfate adenylate transferase</fullName>
            <shortName evidence="7">SAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">sat</name>
        <name evidence="10" type="ORF">NTE_02663</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>sulfate + ATP + H(+) = adenosine 5'-phosphosulfate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:18133"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="EC" id="2.7.7.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the sulfate adenylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.4" evidence="7"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701230.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MT02"/>
    <dbReference type="STRING" id="1459636.NTE_02663"/>
    <dbReference type="GeneID" id="41598355"/>
    <dbReference type="KEGG" id="nev:NTE_02663"/>
    <dbReference type="eggNOG" id="arCOG04191">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022950_1_1_2"/>
    <dbReference type="OrthoDB" id="6358at2157"/>
    <dbReference type="UniPathway" id="UPA00140">
        <property type="reaction ID" value="UER00204"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004781">
        <property type="term" value="F:sulfate adenylyltransferase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070814">
        <property type="term" value="P:hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00517">
        <property type="entry name" value="ATPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.400.10">
        <property type="entry name" value="Sulfate adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00066">
        <property type="entry name" value="Sulf_adenylyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025980">
        <property type="entry name" value="ATP-Sase_PUA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020792">
        <property type="entry name" value="SO4_adenylyltransferase_pro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024951">
        <property type="entry name" value="Sulfurylase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002650">
        <property type="entry name" value="Sulphate_adenylyltransferase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003166">
        <property type="entry name" value="PRK04149.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00339">
        <property type="entry name" value="sopT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43509">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43509:SF1">
        <property type="entry name" value="SULFATE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01747">
        <property type="entry name" value="ATP-sulfurylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14306">
        <property type="entry name" value="PUA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 7 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP-sulfurylase PUA-like" evidence="9">
        <location>
            <begin position="5"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Sulphate adenylyltransferase catalytic" evidence="8">
        <location>
            <begin position="161"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIF84706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="376" mass="42333" checksum="27B9F0A4F7163DEA" modified="2014-10-29" version="1">MALQQPHGGRLVSRFSNASLDGMFAVEVSNDLRSDIENIADGIFSPLEGFVGQDDFDSIVKTGRLKSGLAWTVPIVLDLDEQAAKNARQAGEVALATAGEKFASLKIEEAYTFDRLASARAVYGTDDLNHPGVAKMSNMKSHLVAGRIEVSKRIPQGQIRKYRKTPKETREEMAQRGWKTVVGFQTRNVPHVAHEMLQKAALNLYDGLFVNPLIGKKKQGDFKDEVILSAYETLINNYYPKNRAMFVTLHTEMRYAGPKEAIHHAIMRKNFGCTHFIVGRDHAGVGSYYHPFASHEIFKNYPDLEIQPVFFPAFYYCKKCLSYANERNCPHGPEVREELSGTKMRRMVSSGEMPAEHLMRPEVSRLIVSFKEPFVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MT37</accession>
    <name>A0A075MT37_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02224</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MT37"/>
    <dbReference type="STRING" id="1459636.NTE_02224"/>
    <dbReference type="KEGG" id="nev:NTE_02224"/>
    <dbReference type="eggNOG" id="arCOG01687">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG03420">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_878842_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12840">
        <property type="entry name" value="HTH_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="363" mass="40089" checksum="C5561C021AF56EC4" modified="2014-10-29" version="1">MNRVSNRYKKCYNCLCVKLPLFINKSLYHYKELYNSIQHICIALARKSLVSVSDYDGQASAKKITVFRDVAQMRVLSNPVAWRIMELLSKEPMYPAQVAKELRIHEQSAYYYIRRLLRAGAVEEAGSNLVRGGTARLYQASSPAFGIELDWGETVVEAPGAGRHRGALRFFEGFVHDGVFDGLIVVGAPEPHGQYKSSARDGHYAVHLAFFLGKVSGVMPAEFAVKLDVDAKAEKVLSGSNLVSIGGPGTNIVTAEFNRYLPIRFDEENFWSGLVDGAGRRYSQDNHGLIAKIKNPYDNGKSSVIVVAGVRSAGTKSAVIALTNYGEEILKRYKSKEDWALVVQGFDMDADGKIDHVDVVSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MT66</accession>
    <name>A0A075MT66_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01938</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700656.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MT66"/>
    <dbReference type="GeneID" id="41597686"/>
    <dbReference type="KEGG" id="nev:NTE_01938"/>
    <dbReference type="HOGENOM" id="CLU_2565543_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="88" mass="9759" checksum="A83E526C665E7BAE" modified="2014-10-29" version="1">MPAIMDSRKEQALLDALGAISKILGREEEFDALISYTRYARTEDSTPSLEDIAAHTPAWVQLLSPPLRKLYDAGYDNGYGDSNLSRPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MT74</accession>
    <name>A0A075MT74_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MT74"/>
    <dbReference type="STRING" id="1459636.NTE_00437"/>
    <dbReference type="KEGG" id="nev:NTE_00437"/>
    <dbReference type="HOGENOM" id="CLU_2968267_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="58" mass="6280" checksum="285BB8D511817C70" modified="2014-10-29" version="1">MSIVNLCSLQYYVVIEMIEAIGYVAMGFIATFAAMEAAWRIAKRDAPALQAAAAARVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MT85</accession>
    <name>A0A075MT85_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Activator of Hsp90 ATPase homologue 1/2-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_00447</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MT85"/>
    <dbReference type="STRING" id="1459636.NTE_00447"/>
    <dbReference type="KEGG" id="nev:NTE_00447"/>
    <dbReference type="eggNOG" id="arCOG05261">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048693_0_0_2"/>
    <dbReference type="OrthoDB" id="9351at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd07814">
        <property type="entry name" value="SRPBCC_CalC_Aha1-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd08894">
        <property type="entry name" value="SRPBCC_CalC_Aha1-like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="ASHA1/2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36929">
        <property type="entry name" value="ATTACHMENT SUBUNIT, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36929:SF5">
        <property type="entry name" value="BLR6751 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Activator of Hsp90 ATPase homologue 1/2-like C-terminal" evidence="2">
        <location>
            <begin position="12"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Activator of Hsp90 ATPase homologue 1/2-like C-terminal" evidence="2">
        <location>
            <begin position="154"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Activator of Hsp90 ATPase homologue 1/2-like C-terminal" evidence="2">
        <location>
            <begin position="300"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF82529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="453" mass="52231" checksum="8B49C92B22F6A2C3" modified="2014-10-29" version="1">MTGTIQKSLVVNAPPAVVFKALTSENDLTHWFPNIARLEPRVGGSVEFRFTRDHKGRSGLDHRVVGKVLEFVPDTTFSMSWKNTSDPDFPDTTVTWTLEPAGNERTRVTLVHAGFEKGSSWFDLHDDGWSYFTVQLAVFCKDNTKEIRKTIIIDAPRELVFNMWTDPEHVTKWWGPRGFTTTIYEMDVRPGGVWRFVMHGPDGTDYQNKIIYDEIVKPERIVYSHVSGPQFRVTATFDEQEDGKTKLTMRMLFESAGERDNVVKKYGAIEGLNQTLERLVEQLAKVSAERQEFVITRVFDAPRDLVWEAFAESERLARWWGPKGFAMLVNKLDFHPGGIFHFSLRSPDGQEMWGKFVYREIVKPERIVFVNSFSDKDGNTTRGPFSATWPLEILSTLTFSEDEKEKTTTLTLRWRPINATEQEHRTFEAEFKSMQQGFGGTFDQLTEYLAKHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTG8</accession>
    <name>A0A075MTG8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcription initiation factor TFIIIB, Brf1 subunit/transcription initiation factor TFIIB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NTE_02445</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TFIIB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226986967.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTG8"/>
    <dbReference type="STRING" id="1459636.NTE_02445"/>
    <dbReference type="GeneID" id="41598153"/>
    <dbReference type="KEGG" id="nev:NTE_02445"/>
    <dbReference type="eggNOG" id="arCOG01981">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043736_0_1_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618:SF13">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="Zn_Ribbon_TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Cyclin-like" evidence="5">
        <location>
            <begin position="117"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="5">
        <location>
            <begin position="211"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF84495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="300" mass="32946" checksum="E61BEE3C6F4C94C6" modified="2014-10-29" version="1">MVMRVSMLCSVCNNGVPVTDPELGEVVCSSCGRVLSDKTLDSRPKWYSFDAEKNNGAGTGSPISLTQHDMGLATMISRANRDSSGRRLDASTHATMQRLRRWDFRTKTNPSRVMAFDGLSGLKAKLGLSDSIVEKTAYIYRKALEKQLMKGRSTSSVLVAAAYIACREAGVSRTLKDISEITYVKRKEISRSYRALVRELDIKVPLADPKRWIGTIANKARVSEKTKRMALTTMDSVVEKGASAGKNPTGIAATVLYMCCLRNKEGATLKSIAEVAGVTEVTIRNNLNYLRLRGVRVAEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTI2</accession>
    <name>A0A075MTI2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTPase HflX</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GTP-binding protein HflX</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hflX</name>
        <name evidence="10" type="ORF">NTE_00523</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer. Associates with the 50S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="5">May associate with membranes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTI2"/>
    <dbReference type="STRING" id="1459636.NTE_00523"/>
    <dbReference type="KEGG" id="nev:NTE_00523"/>
    <dbReference type="eggNOG" id="arCOG00353">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019597_2_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11060">
        <property type="entry name" value="GTPase HflX, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00900">
        <property type="entry name" value="GTPase_HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030394">
        <property type="entry name" value="G_HFLX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032305">
        <property type="entry name" value="GTP-bd_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016496">
        <property type="entry name" value="GTPase_HflX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025121">
        <property type="entry name" value="GTPase_HflX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042108">
        <property type="entry name" value="GTPase_HflX_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03156">
        <property type="entry name" value="GTP_HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10229">
        <property type="entry name" value="GTP-BINDING PROTEIN HFLX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10229:SF8">
        <property type="entry name" value="GTPASE HFLX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16360">
        <property type="entry name" value="GTP-bdg_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13167">
        <property type="entry name" value="GTP-bdg_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006809">
        <property type="entry name" value="GTP-binding_hflX_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51705">
        <property type="entry name" value="G_HFLX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hflx-type G" evidence="9">
        <location>
            <begin position="184"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="150"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="190"/>
            <end position="197"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="215"/>
            <end position="219"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="237"/>
            <end position="240"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="333"/>
            <end position="335"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR006809-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR006809-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIF82604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="358" mass="40361" checksum="C5662562A1D4AA14" modified="2014-10-29" version="1">MRPVVLVSYPDPFAAEEAKSLVESADRSIAGMFTQKYLNHSRYGVGSGKAEEIKEFVKESKAEQIVVDEHLTSRQIYNLEKLAGVQVIDRERLILDIFYSRATSTEAKLQIELAEIEYEMPRVRENAKLTSGGERAGKGGMGEYVVDVRFRDLKRRMSFIKEKLKNAQRKRELYHQQRVRIGTPVVSLVGYTSSGKTTLFNLLTGEHKQTSSNLFTTLSTTTRSLRIHNEHEVLLTDTVGFISRLPTYMIDAFKSTLEESLAADLILLLIDVSEGLREIRIKYTACRSVLEELKADRSKVLVVFTKYDSLANPEETTRQIAEDLGIPNPVAISSKSGYGISKLRTMIGQHQYVISASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTI5</accession>
    <name>A0A075MTI5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02893</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701419.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTI5"/>
    <dbReference type="STRING" id="1459636.NTE_02893"/>
    <dbReference type="GeneID" id="41598572"/>
    <dbReference type="KEGG" id="nev:NTE_02893"/>
    <dbReference type="HOGENOM" id="CLU_1357954_0_0_2"/>
    <dbReference type="OrthoDB" id="8751at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="197" mass="22709" checksum="B10FF387F4BF1EFB" modified="2014-10-29" version="1">MNPQIFEAFKKRYKGKLPGMSDSEKVRTYMAWCKENRMEEVILRLSSESKGGWSNNLTLDFTTERVIVSRKSFLAKFADFGYVAGLAPYPYLLTMKKNTGDASKIRKQANFTPEDLLQNENLDYFVWYSDIRELALRKGWETMVTNMMGRAIVSNFLTIMTDDGKIHDFTLPVNKNGLYESVSFWLGVALPIKIVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTJ8</accession>
    <name>A0A075MTJ8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02471</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTJ8"/>
    <dbReference type="STRING" id="1459636.NTE_02471"/>
    <dbReference type="KEGG" id="nev:NTE_02471"/>
    <dbReference type="HOGENOM" id="CLU_2613423_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="78" mass="8745" checksum="150228C44D2E1538" modified="2014-10-29" version="1">MYIFKIIFQTNVNLILKYGKVDSVPGAKMAFEIHASYLAFGISLPLVVWFVATHRKELAGKETIVTRRHYTATDTAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTN4</accession>
    <name>A0A075MTN4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cysteine synthase</fullName>
            <ecNumber evidence="5">2.5.1.47</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_02448</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.47" evidence="5"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701063.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTN4"/>
    <dbReference type="STRING" id="1459636.NTE_02448"/>
    <dbReference type="GeneID" id="41598155"/>
    <dbReference type="KEGG" id="nev:NTE_02448"/>
    <dbReference type="eggNOG" id="arCOG01430">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021018_1_0_2"/>
    <dbReference type="OrthoDB" id="10138at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000003">
        <property type="entry name" value="Cystathionine beta-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="4">
        <location>
            <begin position="10"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF84498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="334" mass="36643" checksum="957DF322A7635126" modified="2014-10-29" version="1">MTTTDSNIDHKIGNTPLAELSSFSTNSIKFYAKLEFCNPFGSVKDRAAYWMIKDAEKRGILKKAKSAIIEPTSGNTGIALAGIARVLGYKVELVVPEKASEETKAILRKLGATLHETSDDLCPRVGAGTDQSIALAKAIAKPRPDIYYMPNQYENEANFLAHYESTGPEIWNQTRGKVTHFIAGCGTGGTITGTATYLKEQNKDVKIIAVQAQKNHLLQGLRNFEESAMPDLFKRRVGVVDEWITATNKESFDTVEMLSRKEKLLVGPSSGSVMSSMIKVAERLEKGVLVGIFADDGRKFKSLYLQQGVFTEGEYVKALENSKSLSGIEIISPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTP2</accession>
    <name>A0A075MTP2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02951</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385571.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTP2"/>
    <dbReference type="STRING" id="1459636.NTE_02951"/>
    <dbReference type="GeneID" id="43502665"/>
    <dbReference type="KEGG" id="nev:NTE_02951"/>
    <dbReference type="HOGENOM" id="CLU_3021101_0_0_2"/>
    <dbReference type="OrthoDB" id="373592at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="55" mass="6518" checksum="10C8941CBE514068" modified="2014-10-29" version="1">MEDEVFKSRAIENAIGILRENKKKQNSKELDFVIDILRERKRQAKLEKEEKIGMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTZ4</accession>
    <name>A0A075MTZ4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03102</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTZ4"/>
    <dbReference type="STRING" id="1459636.NTE_03102"/>
    <dbReference type="KEGG" id="nev:NTE_03102"/>
    <dbReference type="HOGENOM" id="CLU_3056952_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="53" mass="5918" checksum="89DF2DEFEE07EB43" modified="2014-10-29" version="1">MRAPGAFGPRRRCMIMPFLHLLLLFLYCAFTNIECEVAENCSPSASSSMAYTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTZ6</accession>
    <name>A0A075MTZ6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00644</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699637.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTZ6"/>
    <dbReference type="STRING" id="1459636.NTE_00644"/>
    <dbReference type="GeneID" id="41596507"/>
    <dbReference type="KEGG" id="nev:NTE_00644"/>
    <dbReference type="eggNOG" id="arCOG07179">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1598935_0_0_2"/>
    <dbReference type="OrthoDB" id="146831at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="166" mass="18851" checksum="5B8142CF8FBB51D7" modified="2014-10-29" version="1">MQSSQAEFQAKVAGLKDFNEAFELVKSAVYEKFKMHRAGLSLILQVMPTNLGAYHILGSNVIVMNSHVLAAIRRLSGSEAEYNAYVFMVLAHEYLHSLGIIDENSVRQMTYDLCKTMLGEDHSSTKMAKEDPSSLFPQLRNMMQTQFGREFQVIKNFDRASQSYIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MU20</accession>
    <name>A0A075MU20_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MU20"/>
    <dbReference type="STRING" id="1459636.NTE_02610"/>
    <dbReference type="KEGG" id="nev:NTE_02610"/>
    <dbReference type="HOGENOM" id="CLU_2091193_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="116" mass="13180" checksum="6FBC9A9BA2FFF826" modified="2014-10-29" version="1">MDQNYDVLLHDSTYSVQYSFHKGSGRIVNIEINHDARTLTLSVETLQDSQLIMAIPQPLYYYALIGNTPGAVELYVHADGNDTPFEQLMDFKKSLVTYIVNIEKGTEQVMLGRRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MU35</accession>
    <name>A0A075MU35_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein (ATP-grasp superfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02642</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701212.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MU35"/>
    <dbReference type="STRING" id="1459636.NTE_02642"/>
    <dbReference type="GeneID" id="41598335"/>
    <dbReference type="KEGG" id="nev:NTE_02642"/>
    <dbReference type="eggNOG" id="arCOG00348">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075000_1_1_2"/>
    <dbReference type="OrthoDB" id="31247at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10900">
        <property type="entry name" value="PAC-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019151">
        <property type="entry name" value="Proteasome_assmbl_chaperone_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038389">
        <property type="entry name" value="PSMG2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35610:SF7">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35610">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09754">
        <property type="entry name" value="PAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159659">
        <property type="entry name" value="Cgl1923-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="247" mass="26731" checksum="BB6C91DD68F27DCE" modified="2014-10-29" version="1">MTMTMKLVVLKELQADDNEFTAFASLPDMGRVGGLVSSFLAQHLKCEQVAEVVSSDKPWVSYSNGVVKSASDTYKIFYDRAHKLLVFTGESQPQDPGQLYALCNAFLDYAQKIGTVKKLYGAGGYLREQLTGAPRVCGVVNRPELKKVLARAGIDLVGSEISSITWFNGVILGLAAERGIDAIGLFGEISETTVPQPLAAKSIVSAFSRLEKIPVDTKPLDQHYESILEEIQKKKEPGPGKFGSGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MU99</accession>
    <name>A0A075MU99_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF218 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02708</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701266.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MU99"/>
    <dbReference type="STRING" id="1459636.NTE_02708"/>
    <dbReference type="GeneID" id="41598397"/>
    <dbReference type="KEGG" id="nev:NTE_02708"/>
    <dbReference type="HOGENOM" id="CLU_1451454_0_0_2"/>
    <dbReference type="OrthoDB" id="5929at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="186" mass="21133" checksum="37DDA4F709A42B50" modified="2014-10-29" version="1">MSEYRFTDGNLLVLYAVHRGKSQDGGLPDYVQERVKVGLETYNMIMKSRPDRHKTMVMIVGEPGPSEKVKEMLVKGGVKPEIIAIDSESRSIGQTIDYIHSMISKKPNPPFIYFIASVWLHDTYNATAISKLKGIKTQFYGALDHRPVHEVEQEKTYDAPKKGGEYYKRKLTNKAVDVVLNIIFPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUC3</accession>
    <name>A0A075MUC3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isopentenyl phosphate kinase</fullName>
            <ecNumber evidence="2">2.7.4.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">NTE_02263</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>isopentenyl phosphate + ATP = isopentenyl diphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:33963"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:65078"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.26"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the isopentenyl phosphate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.26" evidence="2"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700914.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUC3"/>
    <dbReference type="STRING" id="1459636.NTE_02263"/>
    <dbReference type="GeneID" id="41597978"/>
    <dbReference type="KEGG" id="nev:NTE_02263"/>
    <dbReference type="eggNOG" id="arCOG00860">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070213_0_0_2"/>
    <dbReference type="OrthoDB" id="15328at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102043">
        <property type="term" value="F:isopentenyl phosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04241">
        <property type="entry name" value="AAK_FomA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024192">
        <property type="entry name" value="Fosfomycin_R_FomA-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040647">
        <property type="entry name" value="IPPK_Arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43654">
        <property type="entry name" value="GLUTAMATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43654:SF1">
        <property type="entry name" value="ISOPENTENYL PHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016496">
        <property type="entry name" value="Kin_FomA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aspartate/glutamate/uridylate kinase" evidence="12">
        <location>
            <begin position="4"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="8"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="11">
        <location>
            <position position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR016496-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR016496-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIF84317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="260" mass="27909" checksum="082296F9FC69955B" modified="2014-10-29" version="1">MQKLALVKLGGSVITFKDKALTANTGAIDGISGALVQLDMPVIVVHGGGSFGHHWSVQYDMHTKPAPYDPHGVAVVHESMIALNQIIVNSMIKAGANPYAVAPCMFTTGHKAIAAKVRQLYEMAKANNVIPVTFGDVVHMGGRKYSILSGDALMSIIAKVLKPSRVIFATNVDGIYRDMKTRELVQELKSARRNGDPVEFSKTAGADVTGGMQRKVREAFKIASMGMDVVLVNGLYPERIVQAAHGEVQTGTVVVKKGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUF9</accession>
    <name>A0A075MUF9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Archaeal/vacuolar-type H+-ATPase subunit C</fullName>
            <ecNumber evidence="3">3.6.3.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_03272</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.14" evidence="3"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701731.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUF9"/>
    <dbReference type="STRING" id="1459636.NTE_03272"/>
    <dbReference type="GeneID" id="41598927"/>
    <dbReference type="KEGG" id="nev:NTE_03272"/>
    <dbReference type="eggNOG" id="arCOG02459">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_784368_0_0_2"/>
    <dbReference type="OrthoDB" id="4272at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.50">
        <property type="entry name" value="ATP synthase (C/AC39) subunit, domain 3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036079">
        <property type="entry name" value="ATPase_csu/dsu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002843">
        <property type="entry name" value="ATPase_V0-cplx_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050873">
        <property type="entry name" value="V-ATPase_V0D/AC39_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044911">
        <property type="entry name" value="V-type_ATPase_csu/dsu_dom_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38682">
        <property type="entry name" value="V-TYPE ATP SYNTHASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38682:SF1">
        <property type="entry name" value="V-TYPE ATP SYNTHASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01992">
        <property type="entry name" value="vATP-synt_AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103486">
        <property type="entry name" value="V-type ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF85301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="353" mass="39371" checksum="E438F74DE2C6AB83" modified="2014-10-29" version="1">MANKVSIPSKIFGTVLAHSMRGKMLSRTELQTLAESRDIEELVTRMKNTIYLDALAKLTKPYTAEKVEGALREHLVNTHAKMVTLSSGAGVLNAYFVKYITWNLKIILKGKALGRTYEELLPKINLRAEELVGRRDLVVKALVAKDFDEAVASLQGSEFGEDARKAAVVYKEKGDVRAFDTFLDHAFYKSLDKSMFGESPLQDVQKLVTVDIDAYNVLAVLRAKYWGLSAQETSDLVAITTTKISRDTLQKMINVEKIQEAIGELSNTAYRDLIPKSAENDIDAIMQLEEGFERVSVRRIMASYRTVFTLGNMLATLKLMMLEIRNLAAIAAGVEQKIPADRIMANLAKTTVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUN7</accession>
    <name>A0A075MUN7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TfuA-like core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02803</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701350.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUN7"/>
    <dbReference type="STRING" id="1459636.NTE_02803"/>
    <dbReference type="GeneID" id="41598491"/>
    <dbReference type="KEGG" id="nev:NTE_02803"/>
    <dbReference type="eggNOG" id="arCOG05002">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090311_0_0_2"/>
    <dbReference type="OrthoDB" id="61834at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012924">
        <property type="entry name" value="TfuA_core"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07812">
        <property type="entry name" value="TfuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TfuA-like core" evidence="1">
        <location>
            <begin position="52"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="227" mass="25334" checksum="892EC7CBB61075B2" modified="2014-10-29" version="1">MAKKPIIFLGPSLSHEKASKILPEAEFRPPAKKGDLLRLAASPDVSMVGLVDGVFLQDYPPTPIEVYQLARREGVLLAGAASLGALRAVELEKFGMVGIGRVFELYKGGKIDADDEVAVTFADGDFHLQSEAMVDIRYNLFLAHKKGIIGKDTKKALAKVAKATYFPHRNYPDIIEATRRKYRDSLNNYDDIDAFQTYIEKNRKSLKEMDAIKLVEFFKARLGAEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUZ9</accession>
    <name>A0A075MUZ9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02953</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUZ9"/>
    <dbReference type="STRING" id="1459636.NTE_02953"/>
    <dbReference type="KEGG" id="nev:NTE_02953"/>
    <dbReference type="HOGENOM" id="CLU_3302555_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="39" mass="4428" checksum="D9999092FC34BFCC" modified="2014-10-29" version="1">MKETMIGYTAAGNKFPVAASDCQYFFVDATEIRKYYILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MV83</accession>
    <name>A0A075MV83_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">dolichyl-phosphooligosaccharide-protein glycotransferase</fullName>
            <ecNumber evidence="6">2.4.99.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Oligosaccharyl transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">NTE_03038</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>an archaeal dolichyl phosphooligosaccharide + [protein]-L-asparagine = an archaeal dolichyl phosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine.</text>
            <dbReference type="EC" id="2.4.99.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endomembrane system</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the STT3 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.21" evidence="6"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701538.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MV83"/>
    <dbReference type="STRING" id="1459636.NTE_03038"/>
    <dbReference type="GeneID" id="41598707"/>
    <dbReference type="KEGG" id="nev:NTE_03038"/>
    <dbReference type="eggNOG" id="arCOG02044">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG04767">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014319_0_0_2"/>
    <dbReference type="OrthoDB" id="12184at2157"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004576">
        <property type="term" value="F:oligosaccharyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00317">
        <property type="entry name" value="cyclophilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003674">
        <property type="entry name" value="Oligo_trans_STT3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048999">
        <property type="entry name" value="STT3-PglB_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048307">
        <property type="entry name" value="STT3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872:SF1">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT STT3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02516">
        <property type="entry name" value="STT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21436">
        <property type="entry name" value="STT3-PglB_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 19" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="19" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="171"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="194"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="383"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="405"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="454"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="18">
        <location>
            <begin position="756"/>
            <end position="914"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="AIF85073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="920" mass="100444" checksum="2295ECD4901F8718" modified="2014-10-29" version="1">MLQGGKSLFSVGSFEFQTKHLLIIAVLAMAFSIAVIMRSYPIKYGAYLNEFDPYFDYRATKYILDNGLDAYWKWHDTMSWYPEGRNIPASSQSGLHVTAAIMYSMFGGGGSLMDFTIMFPVVIGSLTVIVVFALVRVLAGTTAGLFASLLFALSPPIILRGNLGWFKSEPLGLFFGLLAAYLFISAIRHKEIKYAIPKAVLGGLLLGLANASWGGIQYFSIPIALFFLALPFFRRDLTIPMYVAVAFTVFTLISAAAFPRPGMSFIAGLPGIAMIGSTVFLVAANFVSKLSKDNERTRQRNMAFLLIAFIAGGLGLIATGSYISPSFRYINAIFPGISSQNALVESVAEHLTPTIADYFVDFSILLMFAGFGAWMAFQRRNDAAVFALIIGITGVYVSATFARLLVFASIGIIVLASIGLFEITRSILETREAQASGPQKGKRKEALAKQPTGTAFRMVYVGIVIAMLLIPVFYPPNSNWVDAVNVPTAIGNGGTVFRTTSTDWLDATKWISEHTEKDAVIASWWDYGYWITTLGNRTTIADNATINQTRIESIAKMFSGDEQSGIKIAQDLKADYVVVYVVGQHQFTGTQNATGISVPVYTLGQGGEESKKNWIMRIGGFDTAKYIESDGFTPKPAFWTNTLLGKLIPYEPGSYVSFTPTGISPPRPTYQPGTVQLYTKNVKYPADGDPNLPFHLAYASPSFYDNSSRIVTGVMIYKVNKDYVPHPTRDPYSPTNTTLADMTPGPQIAEINTTQGMIKAEFFPKAAPKTVDNFIKLANEGFYDGTAFHRLIPGFVIQGGDPLTKNATADRNRWGTGGPGYTIDAEFTDIPHTRGILSMARTADDPNSAGSQFFVVLDNNEQIRAALDGQYTAFGRVIEGMDVVDKISNLPTVGGSDQRVSDHIANPDDARIISVKIVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MV91</accession>
    <name>A0A075MV91_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">proline dehydrogenase</fullName>
            <ecNumber evidence="3">1.5.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NTE_03538</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23784"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.5.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 1/2.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.2" evidence="3"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701940.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MV91"/>
    <dbReference type="STRING" id="1459636.NTE_03538"/>
    <dbReference type="GeneID" id="41599156"/>
    <dbReference type="KEGG" id="nev:NTE_03538"/>
    <dbReference type="eggNOG" id="arCOG06322">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061158_0_0_2"/>
    <dbReference type="OrthoDB" id="8727at2157"/>
    <dbReference type="UniPathway" id="UPA00261">
        <property type="reaction ID" value="UER00373"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:L-proline catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008219">
        <property type="entry name" value="PRODH_bac_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002872">
        <property type="entry name" value="Proline_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015659">
        <property type="entry name" value="Proline_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914:SF0">
        <property type="entry name" value="PROLINE DEHYDROGENASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914">
        <property type="entry name" value="PROLINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01619">
        <property type="entry name" value="Pro_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000196">
        <property type="entry name" value="Pro_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proline dehydrogenase" evidence="10">
        <location>
            <begin position="50"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIF85566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="303" mass="33898" checksum="10EF66CEAF7F8E83" modified="2014-10-29" version="1">MKRVNVLLTTTAATQALHSHSYDSSLLERLLFRVAKRWVAGYSADEAINAALDANRRGMSAILNFLGEDVVDKAQVGLAVREYLSLMDLTKAKGVRGCVSAKPTQLGLAVDYDMCLQNFIALAKKAEELGQFLWIDMESAKFTEDTITIYLEVLKEYPMTGVAIQAYLRRSGADILHIIEHGGKVRLVKGAYHEPEEHAFTTEEEVDGNYSHLLKMLADGGNFFAVATHDGRLVDEAANLQANNCEFQMLMGIRDELKSQLVSRGLPVSEYIPYGSQWLPYSVRRIRERKRNLLLLARSLVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVD6</accession>
    <name>A0A075MVD6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cupin type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02583</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVD6"/>
    <dbReference type="STRING" id="1459636.NTE_02583"/>
    <dbReference type="KEGG" id="nev:NTE_02583"/>
    <dbReference type="eggNOG" id="arCOG03444">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1700200_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43698:SF1">
        <property type="entry name" value="BLL4564 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43698">
        <property type="entry name" value="RIBD C-TERMINAL DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-2" evidence="1">
        <location>
            <begin position="44"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="136" mass="15480" checksum="70E5A895C7639C8D" modified="2014-10-29" version="1">MYVMLKGNIRDIAPDQAMLKYFEGQVEIKKMVTDAASKEAEAYLVTFLRGARTKLHYHETDQILIATKGKGIVALQTEVKMESDSVARVRMDDVHTLEEGDFVCVPAYVWHWHGAQKGEDFAHIQVKKPGKTTWLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVE2</accession>
    <name>A0A075MVE2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative Na+-dependent transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NTE_03104</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987036.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVE2"/>
    <dbReference type="STRING" id="1459636.NTE_03104"/>
    <dbReference type="GeneID" id="41598764"/>
    <dbReference type="KEGG" id="nev:NTE_03104"/>
    <dbReference type="eggNOG" id="arCOG02191">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077102_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002657">
        <property type="entry name" value="BilAc:Na_symport/Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01758">
        <property type="entry name" value="SBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF85138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="295" mass="31556" checksum="79BC20700BEA93B6" modified="2014-10-29" version="1">MRPSNDAILACAIAGSMAAGVLVPQVGLMVEPYLLVWLGILLFLNLIKLEASDVVATFARPRGLAVLALVKLVALPVGMYALTYALYRPLALPVLLVSGMSTGLGAPFVTNIVGGRLPLVVGMIIATSLSVPFVLPSLTYALVGSEFDLPIANMILLLVLALFIPLFGGWAVKKKAPKASEFAHRNSFYLSIIFAILINVSMFSKLSGFFFSDQVFLLQNIAATFLCYAAFALVGFAVSPKTEKPAGMIATSYVNNTLVMVFAAQFFGPQVAALAGLYNIPYYACILVLKKIVRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVG7</accession>
    <name>A0A075MVG7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">50S ribosomal protein L29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02614</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701191.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVG7"/>
    <dbReference type="GeneID" id="41598309"/>
    <dbReference type="KEGG" id="nev:NTE_02614"/>
    <dbReference type="HOGENOM" id="CLU_2821047_0_0_2"/>
    <dbReference type="OrthoDB" id="374677at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="67" mass="7992" checksum="19BD2F731B141651" modified="2014-10-29" version="1">MDSKNLATLTPSDIDALLELVTQEERYVMLLILKNPKESKKREWRVKRLKYLDDLSQKLEYLKKQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVJ7</accession>
    <name>A0A075MVJ7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03226</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701688.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVJ7"/>
    <dbReference type="STRING" id="1459636.NTE_03226"/>
    <dbReference type="GeneID" id="41598882"/>
    <dbReference type="KEGG" id="nev:NTE_03226"/>
    <dbReference type="HOGENOM" id="CLU_2140091_0_0_2"/>
    <dbReference type="OrthoDB" id="11810at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="112" mass="13095" checksum="C2BC7956F5A09978" modified="2014-10-29" version="1">MLVKVNSIIRRNEGQEEGKEENQYIVRVTKLDIDDLGSVIPLREIELWLPLYDESIVKTLMNSHYAAIFTEGYNEEDGSTIILARGFTEEELNKEKEKTIKKVNEKRRDHTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVL1</accession>
    <name>A0A075MVL1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5679 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03241</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701701.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVL1"/>
    <dbReference type="GeneID" id="41598896"/>
    <dbReference type="KEGG" id="nev:NTE_03241"/>
    <dbReference type="eggNOG" id="arCOG07442">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2730558_0_0_2"/>
    <dbReference type="OrthoDB" id="30510at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044044">
        <property type="entry name" value="DUF5679"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18930">
        <property type="entry name" value="DUF5679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5679" evidence="1">
        <location>
            <begin position="8"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="68" mass="7637" checksum="862C8CB5423B3C79" modified="2014-10-29" version="1">MIAAKQTYCTKCKTNVDIIDGKYARLANNRAVFEGQCSQCGTKLTKARVMPRSSSAIMVKRRRKGLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVM1</accession>
    <name>A0A075MVM1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF937 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03251</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701711.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVM1"/>
    <dbReference type="GeneID" id="41598906"/>
    <dbReference type="KEGG" id="nev:NTE_03251"/>
    <dbReference type="HOGENOM" id="CLU_1943928_0_0_2"/>
    <dbReference type="OrthoDB" id="375542at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.110">
        <property type="entry name" value="Uncharacterized conserved protein DUF2267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038282">
        <property type="entry name" value="DUF2267_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="129" mass="14100" checksum="2E6BACBB4508B95C" modified="2014-10-29" version="1">MSTQDLANQLAQRVGITPEQASTAINLLSKTLLQKADPNKASSLLSKLPSSITSMFSDSEKQQFTTTQQSLSGEEVVNKIKTDAGINDQKKAQQTTEEAVKLLQEKTGEGDLLDNVMGRFKKIDLNPFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVR6</accession>
    <name>A0A075MVR6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SPW repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02674</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVR6"/>
    <dbReference type="STRING" id="1459636.NTE_02674"/>
    <dbReference type="KEGG" id="nev:NTE_02674"/>
    <dbReference type="HOGENOM" id="CLU_166551_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="119" mass="12848" checksum="8FE66EF8034E3FD6" modified="2014-10-29" version="1">MARHKEIPLWGWLAIIGYMVLADNLMPSPYEGWALVAGWFAAGALCLVNYGSCGRYHCKITGPGFLGLGILALLDTIGVVNLPAWVTFTTLIAVLAVGFGLEYRYKSKCGTCYAALDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVR9</accession>
    <name>A0A075MVR9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl13</name>
        <name evidence="5" type="ORF">NTE_01336</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700180.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVR9"/>
    <dbReference type="STRING" id="1459636.NTE_01336"/>
    <dbReference type="GeneID" id="41597135"/>
    <dbReference type="KEGG" id="nev:NTE_01336"/>
    <dbReference type="eggNOG" id="arCOG04242">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076922_1_0_2"/>
    <dbReference type="OrthoDB" id="7668at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_uL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_uL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005823">
        <property type="entry name" value="Ribosomal_uL13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005755">
        <property type="entry name" value="Ribosomal_uL13_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_uL13_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01077">
        <property type="entry name" value="L13_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005004">
        <property type="entry name" value="PRK06394.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002181">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF83404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="153" mass="17104" checksum="A9F66008F611229C" modified="2014-10-29" version="1">MADNKAKKPQTIVVDATNCIAGRMCSHVSKLLLQGNKVAIVNAEKAMLSGNRYKVIEQYKEHLEINSVTNPIHGPFHPRRPDTVLTKMVRGMVPKQKTSGIEAHQRLRVYIGVPEEMKAAKMQSFEDSKITRPEAHYISMGDVAKQIGWKGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVU3</accession>
    <name>A0A075MVU3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVU3"/>
    <dbReference type="KEGG" id="nev:NTE_02700"/>
    <dbReference type="HOGENOM" id="CLU_1656806_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="159" mass="17427" checksum="8CD8A31A140520E1" modified="2014-10-29" version="1">MELPSHRYRRFAGAGLCIVCAFLFMPIIITPSVYAQSAPYPIEIESVRLMDPSGHPLNDCRSGEGLVMIAVTLRNLSNSVQPAAIIVDLQDNSNGISQFVQWQTMSINSNDVQQMALSFDPSSLPSSSTVQYDAKVFVWDKVLTPVPLADPLKVPISCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVW4</accession>
    <name>A0A075MVW4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701283.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVW4"/>
    <dbReference type="STRING" id="1459636.NTE_02725"/>
    <dbReference type="GeneID" id="41598415"/>
    <dbReference type="KEGG" id="nev:NTE_02725"/>
    <dbReference type="HOGENOM" id="CLU_1574997_0_0_2"/>
    <dbReference type="OrthoDB" id="8524at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="170" mass="18489" checksum="468FD3D5060B09C1" modified="2014-10-29" version="1">MSQPETVSVSVTVGDVKVQFSGTADSVMASVFNFLSKQVPSMDLAKRISLNYEVTELISRYAHLVKITPEGPRVIPDSSDARLSDKDMVALQLVSARIAKDTGKAQDDAMQVSEIQSATALNPKSISSRISEMVKAGHVARDEKEPGKYRITTAGIHWLNSIVEKKVSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVZ8</accession>
    <name>A0A075MVZ8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DITPase</fullName>
            <ecNumber evidence="4">3.6.1.19</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_02756</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the HAM1 NTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.19" evidence="4"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987000.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVZ8"/>
    <dbReference type="STRING" id="1459636.NTE_02756"/>
    <dbReference type="GeneID" id="41598445"/>
    <dbReference type="KEGG" id="nev:NTE_02756"/>
    <dbReference type="eggNOG" id="arCOG04184">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082080_1_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009143">
        <property type="term" value="P:nucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00515">
        <property type="entry name" value="HAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002637">
        <property type="entry name" value="RdgB/HAM1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011396">
        <property type="entry name" value="PRK14821.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00042">
        <property type="entry name" value="RdgB/HAM1 family non-canonical purine NTP pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067:SF9">
        <property type="entry name" value="INOSINE TRIPHOSPHATE PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067">
        <property type="entry name" value="INOSINE TRIPHOSPHATE PYROPHOSPHATASE/HAM1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01725">
        <property type="entry name" value="Ham1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="ITPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF84797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="190" mass="21146" checksum="246276F4D463C6AC" modified="2014-10-29" version="1">MQPATAIVTFASTNQNKFREVESILAMRGIQASFAKIELVEIQSDSLEEIAREKAKSAYARVQKPVIVEDDGLFVDALGGFPGQYSSYVFKTIGNAGVLKLLEGKQDRLASFRSLVAFFDGNNLQLFEGKVQGRISEKITEGGWGYDPIFAPEGADVTFAELADKKNDYSHRKKALEKFAEWQLLIQNRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MW28</accession>
    <name>A0A075MW28_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ChrB C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02786</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701336.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MW28"/>
    <dbReference type="STRING" id="1459636.NTE_02786"/>
    <dbReference type="GeneID" id="41598475"/>
    <dbReference type="KEGG" id="nev:NTE_02786"/>
    <dbReference type="eggNOG" id="arCOG10427">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121884_0_0_2"/>
    <dbReference type="OrthoDB" id="7455at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018634">
        <property type="entry name" value="ChrB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09828">
        <property type="entry name" value="ChrB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ChrB C-terminal" evidence="1">
        <location>
            <begin position="3"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="152" mass="17156" checksum="66CD25C43649AE25" modified="2014-10-29" version="1">MKWVTREHAKIDRIACPWLIKNFVDRDAEFLFVAADKVMQTAKEMDAIPFDVPNAELGHHGEECSFDAIVKKYDLARKEPALLELARIVRGADTPNRSLTPQSEGLVAMATGFSLISKDDYDNMAKQFYLYDALYAFCKSTNTKSTSSSSRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MW47</accession>
    <name>A0A075MW47_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7508 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02812</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701358.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MW47"/>
    <dbReference type="STRING" id="1459636.NTE_02812"/>
    <dbReference type="GeneID" id="41598499"/>
    <dbReference type="KEGG" id="nev:NTE_02812"/>
    <dbReference type="HOGENOM" id="CLU_2327140_0_0_2"/>
    <dbReference type="OrthoDB" id="9435at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055930">
        <property type="entry name" value="DUF7508"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24348">
        <property type="entry name" value="DUF7508"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7508" evidence="1">
        <location>
            <begin position="11"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="100" mass="11382" checksum="F510E6008B9C73AF" modified="2014-10-29" version="1">MSEEQQQEWSEWLDFDSAHVNSVPEAAGVYLMHASMKVMRIGGSDNVRKSLQELLADPCASKAKRFHYMLTQSHASVAEQLVKDYKEKHQGKLPACMEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MW51</accession>
    <name>A0A075MW51_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NTE_03344</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701789.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MW51"/>
    <dbReference type="STRING" id="1459636.NTE_03344"/>
    <dbReference type="GeneID" id="41598993"/>
    <dbReference type="KEGG" id="nev:NTE_03344"/>
    <dbReference type="eggNOG" id="arCOG04397">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_33_0_2"/>
    <dbReference type="OrthoDB" id="10960at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029:SF10">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="378"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="445"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="9">
        <location>
            <begin position="78"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIF85373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="502" mass="53264" checksum="495EE2BE050D76F9" modified="2014-10-29" version="1">MSRPNWHMYAVVAAVAIAFLVVLGLSQQQYAFAYAPDDPAVPFHCWQTNEDGTNKIVVDNSTGAQSLVPCEINHGDNAWMLTSSALVLMMTPAGLAIFYGGLARQKNAVNTLHMVFITTGVIAVQWALWGYSLAFGPDAGGYGFIGTLDWAGLQNVLHDVPSNAYGGIDGFTIPHMTYMVFQMMFAIITPALIVAAVAERMKFSAFIIFIVIWATFVYDFAAHWTWEITAPDNYGRNPGYCNFGWGGCLGALDFAGGTVIHITSGWSGLVIALMLGRRLGYGKVPMEPHNVSLVVLGAALLWTGWFGFNAGSAAAAATNATSAFVATQIATGMAAVTWALISWAHTGRPSTIGAASGAVAGLVAITPASGFVSPMSSIIIGILASTVCYAAVAFKNRRKWDDALDTWGVHGVGGLAGAILTGIFAEKRFTPWGDNGLAFGNPAQLYENSVGAFAALAWAMGITAVIIKIMDVVWPGGIRVTPKEEEVGLDLSQHGERAYVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MW97</accession>
    <name>A0A075MW97_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chaperonin GroEL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NTE_02889</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385563.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MW97"/>
    <dbReference type="STRING" id="1459636.NTE_02889"/>
    <dbReference type="GeneID" id="41598568"/>
    <dbReference type="KEGG" id="nev:NTE_02889"/>
    <dbReference type="eggNOG" id="arCOG01257">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008891_7_3_2"/>
    <dbReference type="OrthoDB" id="6822at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00309">
        <property type="entry name" value="chaperonin_type_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF84927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="518" mass="56531" checksum="DC9300509BD7AB8D" modified="2014-10-29" version="1">MSAPNYGVWRPIAEHVEYNALESNSSAVMAVADCVRTTLGPKGLDKLLIDQAMNRHVSNDGVTILLSLKAIHPVARMIVEIAERQEQLVGDGTTTAVVMSAEMIKEGKRLIKELGVHPTKVVEGIESGVRHACHLLEEDAKAITINDLELEHVVTTSLSSKLDGARLAKMVITALRTVGENAKYNGEYDFGKAIMVLRKTSMEDQVVNGIVLERKRLDPEIPQEVRGARILITKMDLKPVKESWIKENKNYQEILLMENDRMAKSREMVDAMLKTGTNAVLIASPEVDQAVEDLLVAKGVFAARVSVEEIDHLTRYTGAKPVRVADDLKRQDILGRAERVYEDEDNSIIYIEGGAGKNMVTMVVSGTTKETSLERWRAAIDGVNAAEAALNTGIVPGGGAAELHIMDKVKNARLKGLEQVGLEVVASALESIMRQILTNAGFNGLERVMTAKTSPPGYGIDINSGEPVDMWKIGVVDPLMVKTMALKAAGEIAKSVLRIDRNLAAEDLSPQAMTETKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWI2</accession>
    <name>A0A075MWI2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Universal stress protein UspA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_03460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701885.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWI2"/>
    <dbReference type="STRING" id="1459636.NTE_03460"/>
    <dbReference type="GeneID" id="41599094"/>
    <dbReference type="KEGG" id="nev:NTE_03460"/>
    <dbReference type="eggNOG" id="arCOG02053">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049301_16_2_2"/>
    <dbReference type="OrthoDB" id="105697at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00293">
        <property type="entry name" value="USP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46268">
        <property type="entry name" value="STRESS RESPONSE PROTEIN NHAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46268:SF25">
        <property type="entry name" value="USPA DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UspA" evidence="2">
        <location>
            <begin position="2"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF85488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="146" mass="15293" checksum="BDD0478D356ECE89" modified="2014-10-29" version="1">MSKILVPVDGSDYSKRALEQALSIAKGNASTGAVVVTAIHVIVPMPTVNVGSQKVLDDAKAKLRSEASKLLDECKATAKERAALDIETVILVGTSPGESIVGFCEKGNFNLIVMGAKGHSKLKDIVLGSTSDKVVHHAKCSVLVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWJ1</accession>
    <name>A0A075MWJ1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Plastocyanin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NTE_01576</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700372.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWJ1"/>
    <dbReference type="STRING" id="1459636.NTE_01576"/>
    <dbReference type="GeneID" id="41597356"/>
    <dbReference type="KEGG" id="nev:NTE_01576"/>
    <dbReference type="eggNOG" id="arCOG02926">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1709035_0_0_2"/>
    <dbReference type="OrthoDB" id="11836at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000923">
        <property type="entry name" value="BlueCu_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028871">
        <property type="entry name" value="BlueCu_1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052721">
        <property type="entry name" value="ET_Amicyanin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36507">
        <property type="entry name" value="BLL1555 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36507:SF1">
        <property type="entry name" value="BLL1555 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00127">
        <property type="entry name" value="Copper-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00196">
        <property type="entry name" value="COPPER_BLUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="Blue (type 1) copper" evidence="6">
        <location>
            <begin position="76"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF83639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="153" mass="16496" checksum="F9103600DED1AB55" modified="2014-10-29" version="1">MTNHAGGISIIAFIVAVGISIGYYQYMYVPAVNAKPILPKAVLEPAESVTVKISPGSSNQGNGKFFVPKDTRAGLGVSNHIIWENTDDVPHSVTSDDGYTDKINGKFDTLATIGLIPGGQKFEFTFTATGTYHYHCEPHPWMQGSVEVTESFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWZ7</accession>
    <name>A0A075MWZ7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWZ7"/>
    <dbReference type="KEGG" id="nev:NTE_03140"/>
    <dbReference type="HOGENOM" id="CLU_2392751_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="93" mass="10347" checksum="39D4972BEF414DF3" modified="2014-10-29" version="1">MEKKAGMAMFVIGVIVLLGQGKVVPFLYAFPLVLFPRFGQPQPDMTNYFNLVPVLSLGISAFAIILIISGVVIFYRARKQNSSNTESFVFQDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MX77</accession>
    <name>A0A075MX77_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">N5-carboxyaminoimidazole ribonucleotide synthase</fullName>
            <shortName evidence="6 8">N5-CAIR synthase</shortName>
            <ecNumber evidence="6 8">6.3.4.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 8">5-(carboxyamino)imidazole ribonucleotide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">purK</name>
        <name evidence="10" type="ORF">NTE_01844</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).</text>
    </comment>
    <comment type="function">
        <text evidence="8">Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + hydrogencarbonate + ATP = 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:19317"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58730"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6 8">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 8">Belongs to the PurK/PurT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.18" evidence="6 8"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MX77"/>
    <dbReference type="STRING" id="1459636.NTE_01844"/>
    <dbReference type="KEGG" id="nev:NTE_01844"/>
    <dbReference type="eggNOG" id="arCOG01597">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011534_0_1_2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00942"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034028">
        <property type="term" value="F:5-(carboxyamino)imidazole ribonucleotide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004638">
        <property type="term" value="F:phosphoribosylaminoimidazole carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000037">
        <property type="entry name" value="Phosphoribosylaminoimidazole carboxylase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PurK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003135">
        <property type="entry name" value="ATP-grasp_carboxylate-amine"/>
    </dbReference>
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        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
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        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005875">
        <property type="entry name" value="PurK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040686">
        <property type="entry name" value="PurK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054350">
        <property type="entry name" value="PurT/PurK_preATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004675">
        <property type="entry name" value="PRK06019.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004679">
        <property type="entry name" value="PRK06019.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01161">
        <property type="entry name" value="purK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11609:SF5">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11609">
        <property type="entry name" value="PURINE BIOSYNTHESIS PROTEIN 6/7, PUR6/7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02222">
        <property type="entry name" value="ATP-grasp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17769">
        <property type="entry name" value="PurK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22660">
        <property type="entry name" value="RS_preATP-grasp-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rudiment single hybrid motif"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6 8 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="1 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 6 8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="9">
        <location>
            <begin position="111"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
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        <location>
            <begin position="182"/>
            <end position="185"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="267"/>
            <end position="268"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIF83904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="391" mass="43406" checksum="1800A29D1580B394" modified="2014-10-29" version="1">MLSMKSPTCVGIIGGGQLGKMIAHEARRMSFRVIVLDPTEGCPASRIADEQIVADFKDEAAIMRLAEKCDVLTYEIELANSTALKQLEEKNYPVRPAPETLRIIQNKHRQKSFLQKHRIAVPDFELVKSEEHLHELCQKFGLPAVLKATEDSYDGRGNFVIKTKGDIHRAYEYFKGREIMLEKFVLFTKEVSIMVARNPSGQIESFPVVENIHKNSILDTTIAPAQISRKVEQKAIKLAKRTMEVLHGAGIFGIEMFVTKRGDVLINEIAPRVHNSGHYTNEACSVSQFEQHLRAVLDLPLAKPELLSPAVMINILGPEDFDGVYAVAGLDAMMKVPGAELYVYGKKVSKPRRKLGHITATGRTVKEALARAKKARNAITLVPAAEKEGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MY18</accession>
    <name>A0A075MY18_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700797.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MY18"/>
    <dbReference type="GeneID" id="41597848"/>
    <dbReference type="KEGG" id="nev:NTE_02119"/>
    <dbReference type="HOGENOM" id="CLU_1648235_0_0_2"/>
    <dbReference type="OrthoDB" id="13474at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="160" mass="19063" checksum="6B7D57B6EC7BFFCD" modified="2014-10-29" version="1">MSELGIAEYFGIGEAVGIMATFFITLYYSRREIRNLRVDLETKVLNDLDDKLHGIIETLVHKPALGRVVDKENKANQSDEMVFSYAILYMCSHAFHMRQRKVLSDNEWNGWLRWMRTTFAQGTIREYWNRDIDPRNWFDPDFEDFINNEIIDKKKTMQNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MYD1</accession>
    <name>A0A075MYD1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NTE_02215</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700875.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MYD1"/>
    <dbReference type="STRING" id="1459636.NTE_02215"/>
    <dbReference type="GeneID" id="41597936"/>
    <dbReference type="KEGG" id="nev:NTE_02215"/>
    <dbReference type="eggNOG" id="arCOG00899">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_820405_0_0_2"/>
    <dbReference type="OrthoDB" id="8248at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022791">
        <property type="entry name" value="L-PG_synthase/AglD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00374">
        <property type="entry name" value="flippase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37693:SF1">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37693">
        <property type="entry name" value="PHOSPHATIDYLGLYCEROL LYSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03706">
        <property type="entry name" value="LPG_synthase_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="5"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF84269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="348" mass="37424" checksum="E4CCF5ACEBC762BB" modified="2014-10-29" version="1">MNWRIAAIPASIVPFIIMFLTTKVSPQDIFAVGLVPFVASAVAAVARIMLQAYRFKYFVRKFIGYDVSSPGKTMAARLAGEFVTYTTPSYVGGEFVRIAWLSKNGVPTGKAAWVATMEIIADVFAVTILAFVAGALAISRGGTAIGVTVLVVALPTFAFWLILILYSAKRNLQVPKFIDRIARRFAKDKADKYITQANKALDDLCTMSRENFSSSKVIKPFAIGLALTFASFLAYGISFMVLADSVGVGIGMFDSLMAVAASNAIANLPITIGGSGLAELGIWAYISNLASVPNLAAIAADSKLSVIIAWRIATYHVPLVIMWIALMKLAIGKRETMVPADGEKKKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MZC2</accession>
    <name>A0A075MZC2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NADH:ubiquinone oxidoreductase subunit 11 or 4L (Chain K)</fullName>
            <ecNumber evidence="8">1.6.5.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NTE_02552</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I subunit 4L family.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.3" evidence="8"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MZC2"/>
    <dbReference type="STRING" id="1459636.NTE_02552"/>
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    <dbReference type="KEGG" id="nev:NTE_02552"/>
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        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_144724_1_1_2"/>
    <dbReference type="OrthoDB" id="56168at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030964">
        <property type="term" value="C:NADH dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.3510:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01456">
        <property type="entry name" value="NDH1_NuoK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001133">
        <property type="entry name" value="NADH_UbQ_OxRdtase_chain4L/K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039428">
        <property type="entry name" value="NUOK/Mnh_C1-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004320">
        <property type="entry name" value="PRK05715.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11434:SF16">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 4L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11434">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT ND4L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00420">
        <property type="entry name" value="Oxidored_q2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF84599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="100" mass="10713" checksum="A642BD552E38614E" modified="2014-10-29" version="1">MTELIDFLIVSVALVAVGIYGIVVKRNAIRMLISIEIIVNAANLVVVAFSRSTGNVQGQVFALFSIAIAAAEVAVGLGLVIVAYRLYKEIDVAEFRSMRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N0D1</accession>
    <name>A0A075N0D1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chaperonin GroEL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NTE_02911</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701435.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N0D1"/>
    <dbReference type="STRING" id="1459636.NTE_02911"/>
    <dbReference type="GeneID" id="41598589"/>
    <dbReference type="KEGG" id="nev:NTE_02911"/>
    <dbReference type="eggNOG" id="arCOG01257">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008891_7_3_2"/>
    <dbReference type="OrthoDB" id="9639at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
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        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="536"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="550"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF84949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="569" mass="61549" checksum="BF15D129FFB41CA0" modified="2014-10-29" version="1">MMAAQTKNQQQQRLFGEGVKRTSGGEARRYNMLAARLISEMVKGLLGPCGMDKVFVDIMGEVTLTKDGATLLRKIDVEHPAAKVLIEASNAVDNAVGDGTTSVVVLAGALVANAEELLELGVLPSTISDGYRRALATATNALLSNAVKYTNSDRKTMERLAMTCMESKAISSCMEKERIAKLVVDAIMAVCNPASAKVEIDDVKVEQKPGSVQDTQLVAGVVIDKTVDSSAMPKSVENAKVLLIDYDLDKKNTRTDAEIGITIPAQIRAYLDEQAFELRKKVQAVIDSGANVVISRGGINTLAQTMLAHAGIMSVRRVKENDLWWLEKATGAKITRDLDSISQSDLGFAGRVCERFVGDDRMVFVEECRNPRSVTILLRAGSAKVLDEFHRSILDALNVLRDFVASPLVVAGGGAAEALAARAVRESARTVEGREQLAILKFADALEEIPLTIAANAGMDVIDAQAQLRAAGAKDGKGWCGVNAFSRRVQDDMLALGVIEPLAVKEQVMNTAAEVADLLLRVDDVVMAKPAYYTHTHSDGTTHSHRGGKQAHDHFDKLGRQQRPMHHYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N0N2</accession>
    <name>A0A075N0N2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02999</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701504.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N0N2"/>
    <dbReference type="STRING" id="1459636.NTE_02999"/>
    <dbReference type="GeneID" id="41598669"/>
    <dbReference type="KEGG" id="nev:NTE_02999"/>
    <dbReference type="HOGENOM" id="CLU_1727158_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="151" mass="16776" checksum="B035CC6D79DC877B" modified="2014-10-29" version="1">MHPAPSLSPPPRIIRIVGILTILAVALNLLLGIQNATTIGIWYNPALPFVVPTLYLDLAFIVPAVVIGIKTFKGKDTWKANMIFQIVFLAAHLNNLVAPYVAHVVQSIASQSYDFIVFDYSLYAIIASFVVLRLLLRRDVRSYYLGIAKTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N0P4</accession>
    <name>A0A075N0P4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N0P4"/>
    <dbReference type="KEGG" id="nev:NTE_03009"/>
    <dbReference type="HOGENOM" id="CLU_1763787_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="147" mass="17328" checksum="D32D5744FB0278DB" modified="2014-10-29" version="1">MASRALRSLAPVYWVFHRMPKLQQSYYSNRQSNFHFLPSSFSWILSSSKASIISAIFIPLSPLLVFKMLVTLSIILGFVMLCYPRIRLLAYPIYRFWLQYILVFDYWLTVRQKGQGRKKSLVKLNIRLLHNNRHICLQRPEANAFTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N245</accession>
    <name>A0A075N245_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701905.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N245"/>
    <dbReference type="GeneID" id="41599117"/>
    <dbReference type="KEGG" id="nev:NTE_03491"/>
    <dbReference type="eggNOG" id="arCOG01055">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_159725_0_0_2"/>
    <dbReference type="OrthoDB" id="140255at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038723">
        <property type="entry name" value="ArnR1-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14947">
        <property type="entry name" value="HTH_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ArnR1-like winged helix-turn-helix" evidence="1">
        <location>
            <begin position="4"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="114" mass="13181" checksum="C3E3A0E11B525517" modified="2014-10-29" version="1">MKNRSRLDIAAAVLDIAESGARKTEIMYQAFLSFPQLEEYLEILQSRGMLEYTAGKKRYNTTKEGKKFLQGYKEVGRFLMPQSNKLTTPEINELRQRKDMVGQWKAGEEVTITK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ML01</accession>
    <name>A0A075ML01_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC-type metal ion transport system, periplasmic component/surface adhesin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_00032</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial solute-binding protein 9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987076.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ML01"/>
    <dbReference type="STRING" id="1459636.NTE_00032"/>
    <dbReference type="GeneID" id="41595984"/>
    <dbReference type="KEGG" id="nev:NTE_00032"/>
    <dbReference type="eggNOG" id="arCOG01005">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016838_1_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1980">
        <property type="entry name" value="Nitrogenase molybdenum iron protein domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006129">
        <property type="entry name" value="AdhesinB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050492">
        <property type="entry name" value="Bact_metal-bind_prot9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006128">
        <property type="entry name" value="Lipoprotein_PsaA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006127">
        <property type="entry name" value="ZnuA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42953:SF3">
        <property type="entry name" value="HIGH-AFFINITY ZINC UPTAKE SYSTEM PROTEIN ZNUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42953">
        <property type="entry name" value="HIGH-AFFINITY ZINC UPTAKE SYSTEM PROTEIN ZNUA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01297">
        <property type="entry name" value="ZnuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00691">
        <property type="entry name" value="ADHESINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00690">
        <property type="entry name" value="ADHESNFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53807">
        <property type="entry name" value="Helical backbone' metal receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF82116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="317" mass="34039" checksum="40FA1D7608A5DE2D" modified="2014-10-29" version="1">MKQGRIALAAIAVVIPLAMVATLYTGVQQQASPSSSATTAAKEESSRLKIVTSFYPLYDFASHVAGDRAEVSSLIPPGIEPHDWEPTPGDVTRARNADLLIINGAGFENWASGIGAKALVNTTEGLDLGPAQKDEEGHVGVNPHVWLDPVLAKHQVDVIRAALARADPANAAYYDENAKKFSSELDALDSAIRQELASCTKSDFISFHDAFKWFSERYGLVQHNIQGVSPEGEVLPQKIQETIQTARSLGIKVIYSEDLVDSRLSNVIASEIPGGKVLVLSPIEGVSSAERAAGIGYMEKMNENLANLKEGLECTTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ML68</accession>
    <name>A0A075ML68_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00087</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ML68"/>
    <dbReference type="STRING" id="1459636.NTE_00087"/>
    <dbReference type="KEGG" id="nev:NTE_00087"/>
    <dbReference type="HOGENOM" id="CLU_084395_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13412">
        <property type="entry name" value="HTH_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="287" mass="32546" checksum="C5F19BD9C92CFCA4" modified="2014-10-29" version="1">MQDLPNKLRVLHVELRQRETTPIKFKYIFEYRREALSSSSFQERQKNDSSSSSSEVICRPREDQQQIIVPLSRHMLLQAMEKLGINAKSLESLTVEQLHDLFNRLSNLTAAAAAAPNNSSNQKERYPLHVDGGVAVLSPIDKRMLKLLLASNGDISSMTLSKELGIPLTTIQRRRKRLVEFLDISCTLALRKFDLRSITFFIAAENGMSTSIAKEILTWPSVMSVARTLSNNNIDIKADVVLKTNKEIIDFSEKIKMMPGVKELFWTESIELIGKNNDMLYSKIDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLK5</accession>
    <name>A0A075MLK5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GRAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00069</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699211.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLK5"/>
    <dbReference type="STRING" id="1459636.NTE_00069"/>
    <dbReference type="GeneID" id="41596019"/>
    <dbReference type="KEGG" id="nev:NTE_00069"/>
    <dbReference type="eggNOG" id="arCOG08807">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1640044_0_0_2"/>
    <dbReference type="OrthoDB" id="8874at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="159" mass="18723" checksum="7DC98F0F0BA7F317" modified="2014-10-29" version="1">MVEWDEQIKAHLFWIWKEDEGFLKRGREGMLVITDRRLAFISKTEMTYRAHDTHSTRQLNRFKAGENVFRPAEGYGIKDLEKDLDKSPDNFEVPFRQIMDISSEEKRWGTLLKVKLNLGDTAKTVKFSIVKGWVTYPAKDPLEFQRMDWTPLINLVKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLN3</accession>
    <name>A0A075MLN3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699234.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLN3"/>
    <dbReference type="STRING" id="1459636.NTE_00106"/>
    <dbReference type="GeneID" id="41596049"/>
    <dbReference type="KEGG" id="nev:NTE_00106"/>
    <dbReference type="HOGENOM" id="CLU_1891320_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="79"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="134" mass="15801" checksum="B705081BBA2C41ED" modified="2014-10-29" version="1">MLISYLQANRASLRPVYSLPPNLERLDRETLERLKERTQKRIEDLELSILALDGIILDCIKRQDQLGYRIPLASQPSYKEELIEKYEKVTEEKKIRSKEYQELKHEIATLNYNLEQLDIVLNTILQEIVDLSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MM31</accession>
    <name>A0A075MM31_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Iron-containing redox enzyme family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00464</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MM31"/>
    <dbReference type="STRING" id="1459636.NTE_00464"/>
    <dbReference type="KEGG" id="nev:NTE_00464"/>
    <dbReference type="HOGENOM" id="CLU_1199236_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14518">
        <property type="entry name" value="Haem_oxygenas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="230" mass="26701" checksum="82D06BA0927FC2E9" modified="2014-10-29" version="1">MVYSQRTDNSAEQFGSKLRIKLALMRDGRSNQFASSSMSIENARAWFKDYLIKAHSIIRASVPLMEVARHRCTVLLADEKNPLLLTSLASYFERHIKEETGHDEWLIQDLEVIGVPRRECLERVPSQVVAELVGSQYYWINHWHPVSLLGYIAFLEGNPPSSEWIQLVRKITDYPEEAFRTIIKHSELDQQHRDDLNDLLDELPLTSEHQKWVTSNALYSAGKFHDIWNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MM42</accession>
    <name>A0A075MM42_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phytoene dehydrogenase-like oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_00475</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699505.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MM42"/>
    <dbReference type="STRING" id="1459636.NTE_00475"/>
    <dbReference type="GeneID" id="41596349"/>
    <dbReference type="KEGG" id="nev:NTE_00475"/>
    <dbReference type="eggNOG" id="arCOG01521">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028676_0_0_2"/>
    <dbReference type="OrthoDB" id="40741at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF3">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="2">
        <location>
            <begin position="94"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="526"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="536"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF82556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="550" mass="58601" checksum="94E2D1AB1443D48B" modified="2014-10-29" version="1">MVEIREKWTIANKNEEEDEEEEERNVDVEIEEEDRLIGGGSDGVGDNDHDIGDRGDKPLQALSTSASSASSSTTAAAAPATITSTDVLIVGAGMAGLTAAVYLARAGKTVVITEQSSSIGGRARTADFEGYHFNQGPHALYLAGPAVKILQELGVKYHGGSPSGYVAIKEGKVFPLPSGLYSMMSSKLLSLSSKIEAIRFLASLSKMETSQFDSISLDSWKKEEIRHQDFAELLETYLRVSSYSNDPKFASAGSLLAQFKLASSGGVLYVDEGWQTLVDGLRDAALDAGEKNVQILTGKKAVGVKQRSNGAWTADLSDGSQINATSLVIATSPSDAYRLFSKEQRPEVITRAAKEAIPVRVATLDVALNSLPRPDRLAGFGIDKPLYLSVHSAFAKLAPSSRAGGSSSNSSNSVEVQGPAAVIHVVKYIGSLTDMDPRATENELERLLDLMQPGWRKVLVKKRFLPNMVVSNALVTASQGGIRGRPPVKVSVAKNLYIVGDWVGHEGLLLDASLSSAKRAAEDILEKRRGDEEQGTVAPATAVPPTTTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MM60</accession>
    <name>A0A075MM60_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00261</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MM60"/>
    <dbReference type="STRING" id="1459636.NTE_00261"/>
    <dbReference type="KEGG" id="nev:NTE_00261"/>
    <dbReference type="HOGENOM" id="CLU_2379251_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="94" mass="11340" checksum="8E73161C175EB8D3" modified="2014-10-29" version="1">MQLTIYEQEETIAKNNTRIQEQKKRIESIEQRYDGGIITTIQKLLEPWFCRSSKKSQKEFKIFLKHTETIWQKFNASFQQFCRARGTAQQFECE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MM98</accession>
    <name>A0A075MM98_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699273.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MM98"/>
    <dbReference type="GeneID" id="41596095"/>
    <dbReference type="KEGG" id="nev:NTE_00158"/>
    <dbReference type="HOGENOM" id="CLU_2581213_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="80" mass="9168" checksum="C629AD2D5E5603C1" modified="2014-10-29" version="1">MALPIALNYFIAISHTISSVSNENAEKKSGERKRQENQKSPNQGQLNEMPRQGNENPPIDLKYNTNEKKKKDQNENEKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMA1</accession>
    <name>A0A075MMA1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699549.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMA1"/>
    <dbReference type="GeneID" id="41596402"/>
    <dbReference type="KEGG" id="nev:NTE_00530"/>
    <dbReference type="HOGENOM" id="CLU_210073_0_0_2"/>
    <dbReference type="OrthoDB" id="377106at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="20"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="63" mass="7402" checksum="0374BCDD62A8E539" modified="2014-10-29" version="1">MDEREYDQLDALTSSSVMEISRLSLIVKNLRQRVESLEKNQTELMDKINELEKQKEDDDDDNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMA8</accession>
    <name>A0A075MMA8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hydrolase or acyltransferase of alpha/beta superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMA8"/>
    <dbReference type="STRING" id="1459636.NTE_00535"/>
    <dbReference type="KEGG" id="nev:NTE_00535"/>
    <dbReference type="eggNOG" id="arCOG01648">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_50_2_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050228">
        <property type="entry name" value="Carboxylesterase_BioH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194">
        <property type="entry name" value="HYDROLASE ALPHA/BETA FOLD FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194:SF2">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN LPX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="31"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="289" mass="31956" checksum="F1AEF1166CFDC42E" modified="2014-10-29" version="1">MTANLPATKSVEVNGTRLHYVELGSDNKQSVVFVHGAVADYRIWQGQIEPFSHHYRVIAYSRRHNYPNEFQEGFQYTADNDGITQFASDLAELIRNLNLAPAHLVGHSDGGFTTLLSACKNPELVGSLVLGEPPAIPLVFKSNDKKDVQLAQALVDNVLKPAGEAMAKGDFEKGVRIFIDGVMSKGFFDQLPPPVRTSMVSNAPGFLKQLPNPMPSGLSVNDLDRASLVPTLFVRGELSPEFFQRATEIIKSRMKRSEEVFIEGATHELGIMTQPQTFNSKVLEFLQKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMF7</accession>
    <name>A0A075MMF7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699583.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMF7"/>
    <dbReference type="GeneID" id="41596441"/>
    <dbReference type="KEGG" id="nev:NTE_00575"/>
    <dbReference type="eggNOG" id="arCOG04557">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_172988_0_0_2"/>
    <dbReference type="OrthoDB" id="11564at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="110" mass="11920" checksum="7E2CFCEDA400FDE2" modified="2014-10-29" version="1">MSSSSSNNSSGQEIRERDERNAIKMQEMSSQWAEVIGQLVDRLTGKETSITYTFDNLTVDMPRAQGPNGQDLGNAQWTINGKVVITAEAHDAVMEGGDSRQRSLAASSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMV6</accession>
    <name>A0A075MMV6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00083</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987084.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMV6"/>
    <dbReference type="GeneID" id="41596031"/>
    <dbReference type="KEGG" id="nev:NTE_00083"/>
    <dbReference type="eggNOG" id="arCOG04038">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_127454_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="181" mass="20331" checksum="51E16A0AAC750526" modified="2014-10-29" version="1">MAHALLSVKVISAGLLLLFMPGRKKFRIELEDAEGSKYNLSLEGNISKDKILKIVEFMDLLNIEGEGATTTTAHGNLEGEFGRANVHPASVGDRIWALVESKFPYGSFTSSDILELYEDTFNEPIKLSIISTYLSRYAERGRLMRNRQGKEWIYRTAKPAGSWVPEQQKASPSSISYDRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMW7</accession>
    <name>A0A075MMW7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MEDS: MEthanogen/methylotroph, DcmR Sensory domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00532</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699550.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMW7"/>
    <dbReference type="GeneID" id="41596404"/>
    <dbReference type="KEGG" id="nev:NTE_00532"/>
    <dbReference type="eggNOG" id="arCOG03567">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1478846_0_0_2"/>
    <dbReference type="OrthoDB" id="386660at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025847">
        <property type="entry name" value="MEDS_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14417">
        <property type="entry name" value="MEDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MEDS" evidence="1">
        <location>
            <begin position="21"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="202" mass="23383" checksum="5941C348A93AA20B" modified="2014-10-29" version="1">MTTTITHPLDFIVTLDSKPMHIALFYEDEEYAREIEYAFLKNGLAKSQHCIYTTHGGDADIERIRTEMIKHGIDVSKFEPAGFLHILKISDPRDDPSGFERGIENLKNKIVGRKKPPIRLVSRFIKEVESEDDARANMLVERTIHSRFFDDYQGGLFMCPYPVDKVPSQVRAEWFLNHMQHHHAAVFAPKYFEGSGLVLERY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMW9</accession>
    <name>A0A075MMW9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699463.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMW9"/>
    <dbReference type="GeneID" id="41596302"/>
    <dbReference type="KEGG" id="nev:NTE_00423"/>
    <dbReference type="eggNOG" id="arCOG08742">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067489_0_0_2"/>
    <dbReference type="OrthoDB" id="11492at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="311"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="338" mass="36272" checksum="54F7B8F4AEF48555" modified="2014-10-29" version="1">MISAAVAAVLFAGLASSQAAHANQMDALLLPAQDSSQVHFTAFRTIELRYPEASALAKTLAGKGERLEFSVQGKDAQAVVDALNRAARERASLLVLENATVNYAATLKDYADRAQISYRVDIKAQISKYVLQKEQDSKPAILDLAWRNLSVQGPVTVAAAGHGEVININQPVGALAAIVPELADKLLAAEASKKIMQDPILDFGRFNLPMQQWHFLFDVTGEQLKNYGVFRPGEGETVSVFSIGESSFREGVYVPKEMDATIDVDGAQVKMHASTPPPSGQVTVAGYAKAEEQNGVEYVTSSSKHTVVPALGFQLQVLMALGGMMGAIAVFVLLKARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMZ6</accession>
    <name>A0A075MMZ6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Xylose isomerase-like TIM barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00115</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMZ6"/>
    <dbReference type="STRING" id="1459636.NTE_00115"/>
    <dbReference type="KEGG" id="nev:NTE_00115"/>
    <dbReference type="HOGENOM" id="CLU_870495_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="321" mass="36081" checksum="708EA15324B4B85D" modified="2014-10-29" version="1">MIIMQLKSTQQEEAFANIAAIINRLHKSHGYRIRGHEVHQTRGVMAKTSLPERAKMVSSFCARNGIRYLAYHSPILGRGQNIWEDKWREKVKESLALTIQEAQAVRKEAGLQSKVVIVFHLTSYMPSKEVPRTHKEKIALYEAAEQEFLKFFKSEQDTDGCVLAVENTYPRHDGDSESIGPFHPSELARMEKHGIMTALDLAHYQLYSNYLSRGKGRLAGDLDRERYGRAPFWDQCIKKDLASSLALLHISDASGFEVRGEALPVGSGEIPFADVLGACNSLGRDVRGTIELSCGHLQKGRLQFESARWLLENVPGAFKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MN38</accession>
    <name>A0A075MN38_9ARCH</name>
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        <submittedName>
            <fullName evidence="6">4-hydroxybenzoate polyprenyltransferase-like prenyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NTE_00860</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699805.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MN38"/>
    <dbReference type="STRING" id="1459636.NTE_00860"/>
    <dbReference type="GeneID" id="41596703"/>
    <dbReference type="KEGG" id="nev:NTE_00860"/>
    <dbReference type="eggNOG" id="arCOG00476">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_846262_0_0_2"/>
    <dbReference type="OrthoDB" id="11851at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1780">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050475">
        <property type="entry name" value="Prenyltransferase_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42723">
        <property type="entry name" value="CHLOROPHYLL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42723:SF1">
        <property type="entry name" value="CHLOROPHYLL SYNTHASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="302"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF82936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="320" mass="34538" checksum="22D4F8C153D648DD" modified="2014-10-29" version="1">MSIITSLNPTGRQKAQVSFAHSQLVLFQSRMKWGIVYALATMAGLLLVPGTIDAMLAETNAATLVQRIVPLPLISLLITTGMFLLNDLLDVDLDRANGKKRPLPSGQVTKKQAWIFITWTNVLAVVLSVATANFASMILVAPMLAIGIMYSAPKIALDDRFLIKTVVIALYYMLCAALGATTAYSLDPLVGSPVVFIHAAFMLGTMRFISSVLNDTGDVDGDKAAGRRTIPIVIGRENTIKMGMMMVVGMAGISWAIYALDGIGIVTASFSSAFAALMVIRLSKTIKGAKDKDFIRKQHKRLLPFDLMLLSGLPIGVFML</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNA2</accession>
    <name>A0A075MNA2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00554</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNA2"/>
    <dbReference type="STRING" id="1459636.NTE_00554"/>
    <dbReference type="KEGG" id="nev:NTE_00554"/>
    <dbReference type="HOGENOM" id="CLU_156997_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="125" mass="14572" checksum="E0B0532AD5196056" modified="2014-10-29" version="1">MKPNVFAMKDWHLEHIEKVAVKFARGLASTATYSEKRNHKKFGTATFCIKQIEYDMKHGVEKSEVMEVFRKIRLDEKYAKLWSNVEALNRLQELEDRLLLTGGQEIVGAAAKDDRFLWHKNAYKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNA3</accession>
    <name>A0A075MNA3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699302.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNA3"/>
    <dbReference type="STRING" id="1459636.NTE_00200"/>
    <dbReference type="GeneID" id="41596125"/>
    <dbReference type="KEGG" id="nev:NTE_00200"/>
    <dbReference type="eggNOG" id="arCOG08677">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_166567_0_0_2"/>
    <dbReference type="OrthoDB" id="12305at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="118" mass="12986" checksum="8B79213912163E61" modified="2014-10-29" version="1">MFDLKEGSKGKEKTMEKNVLMKRANTLDEGVVAFGEWLMSVDNDPARSASCGPLSLKKFVADEYAVLMDASLGEQVVVEIVDGIPECKKCADPDCMHIGFTICASQMMNRRNGMVNFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNE4</accession>
    <name>A0A075MNE4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNE4"/>
    <dbReference type="KEGG" id="nev:NTE_00245"/>
    <dbReference type="HOGENOM" id="CLU_2392747_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="93" mass="10428" checksum="B374ACE819754EF4" modified="2014-10-29" version="1">MTPEETQRTDFVPKQKSLGLAILLSVLISGLGQIYLGFVKRGVLILAGGIGYSAAVNFLLGPYLDWLTIALILPFFIWQVYDTYKLYKLRSMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNL8</accession>
    <name>A0A075MNL8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NTE_00325</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699392.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNL8"/>
    <dbReference type="GeneID" id="41596224"/>
    <dbReference type="KEGG" id="nev:NTE_00325"/>
    <dbReference type="eggNOG" id="arCOG05380">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053359_6_1_2"/>
    <dbReference type="OrthoDB" id="11908at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052053">
        <property type="entry name" value="IM_YidH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34187:SF2">
        <property type="entry name" value="DUF202 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34187">
        <property type="entry name" value="FGR18P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="7">
        <location>
            <begin position="16"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF82407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="146" mass="16246" checksum="867D239009E11523" modified="2014-10-29" version="1">MPDDENRRRPIDLAQQYLANERTFLSWLRTSIALIGLGFVVARFGLFLREFQLVVIQREVEAAASSSNNVIQQLPEHSFSSILGVLMIALGVALIFYSLKSYRDGNKEIESGVYVPKKSVVYTGAILLAIFGGATILYLLTVSLMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNM3</accession>
    <name>A0A075MNM3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Putative [LysW]-aminoadipate/[LysW]-glutamate kinase</fullName>
            <ecNumber evidence="9">2.7.2.17</ecNumber>
            <ecNumber evidence="9">2.7.2.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">lysZ</name>
        <name evidence="11" type="ORF">NTE_00735</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in both the arginine and lysine biosynthetic pathways. Phosphorylates the LysW-bound precursors glutamate (for arginine biosynthesis), respectively alpha-aminoadipate (for lysine biosynthesis).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[amino-group carrier protein]-C-terminal-N-(1,4-dicarboxybutan-1-yl)-L-glutamine + ATP = [amino-group carrier protein]-C-terminal-N-(1-carboxy-5-phosphooxy-5-oxopentan-1-yl)-L-glutamine + ADP</text>
            <dbReference type="Rhea" id="RHEA:41944"/>
            <dbReference type="Rhea" id="RHEA-COMP:9694"/>
            <dbReference type="Rhea" id="RHEA-COMP:9712"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:78499"/>
            <dbReference type="ChEBI" id="CHEBI:78503"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[amino-group carrier protein]-C-terminal-gamma-(L-glutamyl)-L-glutamate + ATP = [amino-group carrier protein]-C-terminal-gamma-(5-phospho-L-glutamyl)-L-glutamate + ADP</text>
            <dbReference type="Rhea" id="RHEA:52632"/>
            <dbReference type="Rhea" id="RHEA-COMP:13311"/>
            <dbReference type="Rhea" id="RHEA-COMP:13313"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:136714"/>
            <dbReference type="ChEBI" id="CHEBI:136717"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amino-acid biosynthesis; L-arginine biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (Thermus route): step 2/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the acetylglutamate kinase family. LysZ subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.17" evidence="9"/>
    <dbReference type="EC" id="2.7.2.19" evidence="9"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699711.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNM3"/>
    <dbReference type="STRING" id="1459636.NTE_00735"/>
    <dbReference type="GeneID" id="41596587"/>
    <dbReference type="KEGG" id="nev:NTE_00735"/>
    <dbReference type="eggNOG" id="arCOG00862">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053680_2_0_2"/>
    <dbReference type="OrthoDB" id="6816at2157"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER00036"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003991">
        <property type="term" value="F:acetylglutamate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043744">
        <property type="term" value="F:N2-acetyl-L-aminoadipate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:L-arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02082">
        <property type="entry name" value="LysZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004662">
        <property type="entry name" value="AcgluKinase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037529">
        <property type="entry name" value="LysZ"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00761">
        <property type="entry name" value="argB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010659">
        <property type="entry name" value="PRK14058.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010662">
        <property type="entry name" value="PRK14058.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23342">
        <property type="entry name" value="N-ACETYLGLUTAMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23342:SF0">
        <property type="entry name" value="N-ACETYLGLUTAMATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000728">
        <property type="entry name" value="NAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 9" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 9" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aspartate/glutamate/uridylate kinase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="37"/>
            <end position="38"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="9">
        <location>
            <position position="5"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="9">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIF82813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="267" mass="28211" checksum="1B1161387C60DBFA" modified="2014-10-29" version="1">MIVIKIGGSVVDGLHPSTLADIKAIAEKEKLVFVHGGGKEVTATATKLGKEQKFIVSPGGVRSRYTDKETADIYTMVMSGKINKAIVGMLLRQGIKAVGVAGVDGGILKAERKKKLMVINEKGRKMVIDGGYTGKINDVDPSLVNTLVNSGYVPVVSPIALSEEFDFLNVDGDRAAAYVAGGVKADKVIFITNVNGLMLNEKLVTGMNLEQAKATLPKIGFGMEKKVLACTEALEMGVREAIIASGQVDNPISSAIAHNNCTVITPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNY7</accession>
    <name>A0A075MNY7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zn-dependent alcohol dehydrogenase</fullName>
            <ecNumber evidence="9">1.1.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NTE_01163</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.1" evidence="9"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNY7"/>
    <dbReference type="STRING" id="1459636.NTE_01163"/>
    <dbReference type="KEGG" id="nev:NTE_01163"/>
    <dbReference type="eggNOG" id="arCOG01455">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_2_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08240">
        <property type="entry name" value="6_hydroxyhexanoate_dh_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000039">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF8">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="8">
        <location>
            <begin position="12"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF83236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="355" mass="38459" checksum="876E18E68EFE37A2" modified="2014-10-29" version="1">MCVPMKAARIVNVNEPLQIQQLEVPKPKGTEILVRIASSGVCHSDIHLWEGGYEGIEGQFLKATDRGVRYPLTPGHEIAGVVETMGETAEGFSKGDRVIVYPWIGDGICPACRAGEENLCDKPRSLGIYTEGGYAEYVLVPSHRYLIKIRDGLDIDLAAVLSCSVLTAYTAVRNAALEPDSNVVIVGAGGLGLMAIQVAKALTGARIIALDIDDDKLQIARKNGADMIINSKKDDPMQRVMELTDKLGADAVIDFVNASKTVETDMQMLRRRAKVVLVGLFGGELKLNLVSMPTRAHKLIGSYTGNLRDLSELVSLAERGIIKPIVSHKFKLEQATEALQMMKDGKIIGRGVLNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MP07</accession>
    <name>A0A075MP07_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00872</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MP07"/>
    <dbReference type="STRING" id="1459636.NTE_00872"/>
    <dbReference type="KEGG" id="nev:NTE_00872"/>
    <dbReference type="eggNOG" id="arCOG08677">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_153621_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="125" mass="14647" checksum="8FE5270A901A4786" modified="2014-10-29" version="1">MLLYMVKRGGKEVITVEIFKQTYDVMKSTAEKMHWNTKEYINSVLVEAIERDRFLQSYAPYFSKIGYQDNILFIRDAKAGKTAEVYLKDKTLYCGLCESKDCSHIHYAFALPEVAKMFLKKPRQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MP27</accession>
    <name>A0A075MP27_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nicotinamidase-like amidase</fullName>
            <ecNumber evidence="3">3.5.1.110</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_00844</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.1.110" evidence="3"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699791.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MP27"/>
    <dbReference type="STRING" id="1459636.NTE_00844"/>
    <dbReference type="GeneID" id="41596687"/>
    <dbReference type="KEGG" id="nev:NTE_00844"/>
    <dbReference type="eggNOG" id="arCOG01943">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068979_8_0_2"/>
    <dbReference type="OrthoDB" id="9194at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00431">
        <property type="entry name" value="cysteine_hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050272">
        <property type="entry name" value="Isochorismatase-like_hydrls"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540:SF6">
        <property type="entry name" value="ISOCHORISMATASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540">
        <property type="entry name" value="PEROXYUREIDOACRYLATE/UREIDOACRYLATE AMIDOHYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="2">
        <location>
            <begin position="12"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF82920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="234" mass="26209" checksum="BD25E0B0E0994E95" modified="2014-10-29" version="1">MATIRGHKVSPALVVIDVQNGFVSKGGSYDLLGMETAHYQQVIPRIAKLISLCRDAGVPVFYTQAVREKSGIDLLTRSHKILPKAREERIRRRPICVRDTWDAGIVDAIKPAPEDHIVIKRRDSAFHDTEIGVWLKSLDVDTLLFCGIDTSICVETSLRDAFNNGYDVVLVSDATASGNRKHFESTLEIVKDYYGFVMDIDELERSLLASQKQVQQKRVASNDDDSNHQKIVQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPF2</accession>
    <name>A0A075MPF2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">K+-transporting ATPase, A chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NTE_00944</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPF2"/>
    <dbReference type="STRING" id="1459636.NTE_00944"/>
    <dbReference type="KEGG" id="nev:NTE_00944"/>
    <dbReference type="eggNOG" id="arCOG04804">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1227619_0_0_2"/>
    <dbReference type="OrthoDB" id="56688at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004623">
        <property type="entry name" value="KdpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30607">
        <property type="entry name" value="POTASSIUM-TRANSPORTING ATPASE A CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30607:SF2">
        <property type="entry name" value="POTASSIUM-TRANSPORTING ATPASE POTASSIUM-BINDING SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03814">
        <property type="entry name" value="KdpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="65"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="132"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIF83020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="225" mass="25390" checksum="410EDAC566302BBD" modified="2014-10-29" version="1">MADPVVQLVVLLGSTVTMAVLFGMYMARMITYESRPLEKTLARVENGFYRMVGIDKDQQMSWKEYLLALVVTNAIVAGFVFVMLVTQGVLPVSQGLAGLSPDLAFHTAASFITNTDLQHYAGDQQLSVFSQMVVMTFVMFVAPASGIAAAFAFIRAFIRKNFGLGNFYVDFIRVIVTLLLPVAFVSALLLMFLECRRRYPRRQQLARWRAASRRWSWAPWHPFCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPG9</accession>
    <name>A0A075MPG9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Transcription elongation factor Spt5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">spt5</name>
        <name evidence="9" type="ORF">NTE_01384</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Stimulates transcription elongation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterodimer composed of Spt4 and Spt5. Interacts with RNA polymerase (RNAP).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SPT5 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the archaeal Spt5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPG9"/>
    <dbReference type="STRING" id="1459636.NTE_01384"/>
    <dbReference type="GeneID" id="41597180"/>
    <dbReference type="KEGG" id="nev:NTE_01384"/>
    <dbReference type="eggNOG" id="arCOG01920">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113589_0_0_2"/>
    <dbReference type="OrthoDB" id="371863at2157"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006354">
        <property type="term" value="P:DNA-templated transcription elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06091">
        <property type="entry name" value="KOW_NusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09887">
        <property type="entry name" value="NGN_Arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.940">
        <property type="entry name" value="NusG, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00950">
        <property type="entry name" value="Spt5_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005100">
        <property type="entry name" value="NGN-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006645">
        <property type="entry name" value="NGN-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036735">
        <property type="entry name" value="NGN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005825">
        <property type="entry name" value="Ribosomal_uL24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011590">
        <property type="entry name" value="Spt5_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00405">
        <property type="entry name" value="KOW_elon_Spt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03439">
        <property type="entry name" value="Spt5-NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00738">
        <property type="entry name" value="NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01108">
        <property type="entry name" value="RIBOSOMAL_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NusG-like N-terminal" evidence="7">
        <location>
            <begin position="65"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="8">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="48"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="NCBIfam" id="TIGR00405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF83451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="210" mass="22966" checksum="B2C2592F43351001" modified="2014-10-29" version="1">MSDPREDQGEDLDEISFDNEDNNQNLEDTEAQRQQQGKGAGAKEEKPASTAAAAAAPQSDKPASDSRFFAIRTTGGQERMVADMLYTKVTAKKIGIRSVMVLDSFKGYIIVEAPDANVAYEGLAGIRHVRGQIRGDLPFKDIEGYLVKKPTVTELSIDDTVEVIAGPFKGMKAKITRVDYEKQEATVVLLDSPYQIPVTVDANYLKKAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPH7</accession>
    <name>A0A075MPH7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Flp pilus assembly protein TadD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_00622</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699621.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPH7"/>
    <dbReference type="STRING" id="1459636.NTE_00622"/>
    <dbReference type="GeneID" id="41596485"/>
    <dbReference type="KEGG" id="nev:NTE_00622"/>
    <dbReference type="eggNOG" id="arCOG03038">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_795968_0_0_2"/>
    <dbReference type="OrthoDB" id="115601at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051685">
        <property type="entry name" value="Ycf3/AcsC/BcsC/TPR_MFPF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF047558">
        <property type="entry name" value="TPR_END_plus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44943">
        <property type="entry name" value="CELLULOSE SYNTHASE OPERON PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44943:SF8">
        <property type="entry name" value="TPR REPEAT-CONTAINING PROTEIN MJ0263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="87"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="121"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="155"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="189"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="257"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF82702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="348" mass="39714" checksum="CABD7BD8A8AE1C62" modified="2014-10-29" version="1">MQTGEFECQKCKGVRKHTLRLYEKKTKAYSVIPAGIDREVTAICHGCLTEWILDKKYEKQLIELYKKWDKEEKLEKKQLKHDDSTGIGSMINEASELASANQYDKAMKLLQKAIKKDPSRPEPYVTTGGILFNQKDYLGALDNFGKALQSEPNNLTALIFTGHSLINLGKDDQALTHIDRALDIAPEESQALWAKGNILIRLGRFAEALDYFDKILLLSPKETTVLIARGECLLDLERNEDVISSFDKALLTDVNNIDALRGKGTALMMLGRNDDALSYFDRVLEMNPNEALTVYRVSCIKTLQGRHSEALNMIQNIININSRYKEIIRKSKNFDNLWNYDEFRKLMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPJ8</accession>
    <name>A0A075MPJ8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heme/copper-type cytochrome/quinol oxidase, subunit 1</fullName>
            <ecNumber evidence="3">1.9.3.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_00990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.9.3.1" evidence="3"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPJ8"/>
    <dbReference type="STRING" id="1459636.NTE_00990"/>
    <dbReference type="KEGG" id="nev:NTE_00990"/>
    <dbReference type="eggNOG" id="arCOG01237">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011899_7_3_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00919">
        <property type="entry name" value="Heme_Cu_Oxidase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.210.10">
        <property type="entry name" value="Cytochrome c oxidase-like, subunit I domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023616">
        <property type="entry name" value="Cyt_c_oxase-like_su1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036927">
        <property type="entry name" value="Cyt_c_oxase-like_su1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000883">
        <property type="entry name" value="Cyt_C_Oxase_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10422">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10422:SF18">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00115">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01165">
        <property type="entry name" value="CYCOXIDASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81442">
        <property type="entry name" value="Cytochrome c oxidase subunit I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50855">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="400"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="442"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome oxidase subunit I profile" evidence="2">
        <location>
            <begin position="1"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF83065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="497" mass="55456" checksum="378A9176E16E56FA" modified="2014-10-29" version="1">MWEILFSSHHTDVGLLYIILSFTAFIIGGALAIAIRTELFLPGTQLIADSTTFHRIFTVHGTNMLFLWLVPFASGMGNYLIPIMVRYKDMAWPKLNAIAFWMIPVGMAMIWMGFSDTTWMAYPPYSTTKAPGPAAEMWIFGLKILGLSSILGAINFVVTILKMKHPDLPLMKTSLFVWGTLVTSLMILVALPTFTAALIMLYTDRLGVTGFFDPTRGGDPIAYQHLFWFTFHPEVYIFLLPAVGMMYELIPKFSRKPLFSYQSGVTAFVLLGIVGFASWAHHMYSTGMSFTEKTVFMVGTLAAVPASAMHIFNWIATMWGGRIKFASPMSFAVGGVVLFFYAGAGGIVNTAMPLDFITHDSYWVVGHFHLFVMGMVTFGFIGFLLYMFPFITGRMFNEKAAMVSFWLFFVGVSLIFLTQHVLGLYGQPRRVYDYVPVQPLIILNQISSVGAWITATGAALLTGILIHGSMKGRYADLKDPFQIGETYFPIAAKEPHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPT7</accession>
    <name>A0A075MPT7_9ARCH</name>
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        <recommendedName>
            <fullName evidence="3">Insertion element protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01513</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385223.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPT7"/>
    <dbReference type="STRING" id="1459636.NTE_01513"/>
    <dbReference type="GeneID" id="43502608"/>
    <dbReference type="KEGG" id="nev:NTE_01513"/>
    <dbReference type="eggNOG" id="arCOG10403">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3194331_0_0_2"/>
    <dbReference type="OrthoDB" id="5580at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="45" mass="5056" checksum="D66DA677FA8705A7" modified="2014-10-29" version="1">MARKTVYGKCPKCKARGDLVVMSGTPGKEKFKCNQCYHVFGMDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPU6</accession>
    <name>A0A075MPU6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acyl dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01523</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700331.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPU6"/>
    <dbReference type="GeneID" id="41597310"/>
    <dbReference type="KEGG" id="nev:NTE_01523"/>
    <dbReference type="eggNOG" id="arCOG10570">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1745471_0_0_2"/>
    <dbReference type="OrthoDB" id="4149at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="149" mass="16751" checksum="9C9DAAFE82C9B98A" modified="2014-10-29" version="1">MKFGEFAIGQEFSTSVTITEADFHAYISFARTRNILHENRELAAKEGIKGTLVPGRAIIARAEGEMTRLPAFSDCIMLLYGMDGDPEWAGRQTRFLGEVYAGDTLDVKYRVASKKEEKNGYGILRVDYEISRFGKTVVVSKGNLYRIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPU7</accession>
    <name>A0A075MPU7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1,4-dihydroxy-6-naphtoate synthase</fullName>
            <ecNumber evidence="3">4.1.99.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Menaquinone biosynthetic enzyme MqnD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mqnD</name>
        <name evidence="4" type="ORF">NTE_00799</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>cyclic dehypoxanthinylfutalosinate = 1,4-dihydroxy-6-naphthoate + dihydroxyacetone</text>
            <dbReference type="Rhea" id="RHEA:33087"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:64254"/>
            <dbReference type="ChEBI" id="CHEBI:64270"/>
            <dbReference type="EC" id="4.1.99.29"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MqnA/MqnD family. MqnD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.29" evidence="3"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPU7"/>
    <dbReference type="STRING" id="1459636.NTE_00799"/>
    <dbReference type="KEGG" id="nev:NTE_00799"/>
    <dbReference type="eggNOG" id="arCOG00654">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070326_0_0_2"/>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016830">
        <property type="term" value="F:carbon-carbon lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00996">
        <property type="entry name" value="MqnD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003773">
        <property type="entry name" value="Menaquinone_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030869">
        <property type="entry name" value="MqnD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37167">
        <property type="entry name" value="1,4-DIHYDROXY-6-NAPHTOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37167:SF1">
        <property type="entry name" value="1,4-DIHYDROXY-6-NAPHTOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02621">
        <property type="entry name" value="VitK2_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="1 3" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="113"/>
            <end position="114"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF82877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="280" mass="30977" checksum="9D4867F1B13DA76A" modified="2014-10-29" version="1">MREMEITLGHTPDADDAFMFYGFACGAVGSSRFAIKHVIQDIETLNKRALAHELDATAVSAHAYAYLKDYVILRGGGSFGLKYGPVVIARKDKGMTLDGLKDATIAIPGRMTSANLLLKLAIGKFREKEMSFEAIPQAVLTGEVDAGLVIHEAQITYDKTKFAGIMELGQWWDSQTGGLPVPLGINVASARTMDRGQLKEFSDLFVKSIEYGLDNIDASVDYAMQYSRGQPKETIKKFVLMYVNEITRDMGPEGRKAIEKMFSMACERRILESDVRVDVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPW7</accession>
    <name>A0A075MPW7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01548</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPW7"/>
    <dbReference type="STRING" id="1459636.NTE_01548"/>
    <dbReference type="KEGG" id="nev:NTE_01548"/>
    <dbReference type="HOGENOM" id="CLU_2856920_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="62" mass="7260" checksum="F439708E2F28D153" modified="2014-10-29" version="1">MYNKQSCRECGAYLVPHSFCMGCREHVSWECGQCGRIDDYTHVHDYCRAVFKREIVVETVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPY4</accession>
    <name>A0A075MPY4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01568</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AIF83631.1"/>
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    </dbReference>
    <dbReference type="RefSeq" id="WP_158385237.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
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    <dbReference type="STRING" id="1459636.NTE_01568"/>
    <dbReference type="GeneID" id="43502615"/>
    <dbReference type="KEGG" id="nev:NTE_01568"/>
    <dbReference type="HOGENOM" id="CLU_3056949_0_0_2"/>
    <dbReference type="OrthoDB" id="382523at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="53" mass="6101" checksum="2981128319F7E084" modified="2014-10-29" version="1">MGMRKGAYRREESGQQKSGKGTIVICELVERDPFTGKILRSERHEILAKIRQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPZ6</accession>
    <name>A0A075MPZ6_9ARCH</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">NTE_00861</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="296" mass="33904" checksum="45165200CA3A1C3B" modified="2014-10-29" version="1">MSEPVNIQHVFSILADRHSVNILKMAYSGFKASSNSYAGNLSKKQFYVRLKRLKEAGLIEKRENIYITTTFGSLVCNSHVKTLEEMLANYWNLKAVDVLKTRQDFPQHQKESVINEIIQSSSLRNIVNSTHLSGFSVVKNYSQLVAEVIKLLGIAQKEVYLATRYHDPNFAKIIFKKISEGLTVHMLDSLPDQISVESRLNAVLRTPPNRETFEMVNALVKSPWFDLRKKEIPASFMVVDGRMVCYETTNYTNPEEFTLAISHYDDPYLAERLISYYNSLAKDAVIPRLLTSIREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQ33</accession>
    <name>A0A075MQ33_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nitrogen regulatory protein P-II</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00901</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987160.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQ33"/>
    <dbReference type="STRING" id="1459636.NTE_00901"/>
    <dbReference type="GeneID" id="68225754"/>
    <dbReference type="KEGG" id="nev:NTE_00901"/>
    <dbReference type="eggNOG" id="arCOG02305">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2712607_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006808">
        <property type="term" value="P:regulation of nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002187">
        <property type="entry name" value="N-reg_PII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00543">
        <property type="entry name" value="P-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="GlnB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="72" mass="8151" checksum="2FD6E61D6C215E17" modified="2014-10-29" version="1">MNKLDIIIPQERLPRLNKLLHKHKVGGMSFYDIKGGGRTIQERVTVGRGVMTYVPEFGFRTKVQVLVPDALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQ39</accession>
    <name>A0A075MQ39_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01613</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700404.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQ39"/>
    <dbReference type="GeneID" id="41597391"/>
    <dbReference type="KEGG" id="nev:NTE_01613"/>
    <dbReference type="HOGENOM" id="CLU_2379254_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="94" mass="10504" checksum="505BE080D63A661E" modified="2014-10-29" version="1">MKRKKFLEQQKEGNSKGAAKDSKYKMKSANEKVKLGTNYAIKEAVMAGNKVNGILDKVNRNRKVTRFAQAADTFGIKPTELYDGDLNVSTSLNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQ80</accession>
    <name>A0A075MQ80_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01274</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700130.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQ80"/>
    <dbReference type="STRING" id="1459636.NTE_01274"/>
    <dbReference type="GeneID" id="41597079"/>
    <dbReference type="KEGG" id="nev:NTE_01274"/>
    <dbReference type="eggNOG" id="arCOG08745">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1559406_0_0_2"/>
    <dbReference type="OrthoDB" id="9026at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="167" mass="18678" checksum="9A6B4122F7EE9841" modified="2014-10-29" version="1">MFGKGGIKPGEFVFVAQKDGQYSRIVIGRIQSVNGSRVHIVGTAIRPSGLVERVNAGKAGDHSKQVLGNPDPNNCVFMLIDRVDTSPFNQEVDQATDRVIWINENRYLVLDGWIKENFPEIFAAALMSQAEEDRQNARQVLREKMGALYERDLKDHVYAVARGAHLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQJ6</accession>
    <name>A0A075MQJ6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01069</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQJ6"/>
    <dbReference type="STRING" id="1459636.NTE_01069"/>
    <dbReference type="KEGG" id="nev:NTE_01069"/>
    <dbReference type="eggNOG" id="arCOG00770">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1536714_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="175" mass="18598" checksum="7DE81836D26BBA5C" modified="2014-10-29" version="1">MVKTRYIAAGAAAVVVIFVLLLAASSYANASLQYRSRGAQGYNFAQSSTDVAMDICNPTPFPAGFDRLQFVATYRDSDFATMKFENVSSIPPNKAVAVDGALQVNGRAALAAVFQSFADSLNGKNTGDTNSMKVKMTSESRLLGFVPVSQSKEMSADEFSNMINGKSGFGCTVND</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQL1</accession>
    <name>A0A075MQL1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQL1"/>
    <dbReference type="STRING" id="1459636.NTE_01760"/>
    <dbReference type="KEGG" id="nev:NTE_01760"/>
    <dbReference type="eggNOG" id="arCOG01365">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2534505_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902555">
        <property type="term" value="C:endoribonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3250">
        <property type="entry name" value="Ribonuclease P, Pop5 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038085">
        <property type="entry name" value="Rnp2-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160350">
        <property type="entry name" value="Rnp2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="83" mass="9209" checksum="D84F77FBBF90B54C" modified="2014-10-29" version="1">MCETMTGVNALAAIQKRHAELFGSIALERAALRLIKDENRVAIMRCSLAEVERVLATIALCDPPIVTLDMSSSTKRLKRRLQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQL2</accession>
    <name>A0A075MQL2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01084</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQL2"/>
    <dbReference type="STRING" id="1459636.NTE_01084"/>
    <dbReference type="KEGG" id="nev:NTE_01084"/>
    <dbReference type="HOGENOM" id="CLU_198712_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="84" mass="9566" checksum="7BD77DAFF0F10FC4" modified="2014-10-29" version="1">MHLRIHIHVQDMAKSSDCVENNHGRCQGHFKEEMNGSQVTRMCACPCHDSMYQLVRNTVALMAQAERQNPYHLAQAANDDDGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQP4</accession>
    <name>A0A075MQP4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Exosome complex component Rrp4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rrp4</name>
        <name evidence="9" type="ORF">NTE_01342</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the RRP4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQP4"/>
    <dbReference type="STRING" id="1459636.NTE_01342"/>
    <dbReference type="KEGG" id="nev:NTE_01342"/>
    <dbReference type="eggNOG" id="arCOG00678">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071769_0_0_2"/>
    <dbReference type="OrthoDB" id="35160at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000178">
        <property type="term" value="C:exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071034">
        <property type="term" value="P:CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22524">
        <property type="entry name" value="KH-I_Rrp4_prokar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05789">
        <property type="entry name" value="S1_Rrp4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000127">
        <property type="entry name" value="Exosome complex component RRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00623">
        <property type="entry name" value="Exosome_Rrp4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026699">
        <property type="entry name" value="Exosome_RNA_bind1/RRP40/RRP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023474">
        <property type="entry name" value="Rrp4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048565">
        <property type="entry name" value="S1_RRP4"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003181">
        <property type="entry name" value="PRK04163.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321:SF4">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321">
        <property type="entry name" value="PNAS-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21262">
        <property type="entry name" value="RRP40_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110324">
        <property type="entry name" value="Ribosomal L27 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0271">Exosome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="S1 motif" evidence="8">
        <location>
            <begin position="62"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="227"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="227"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="254"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="267"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF83410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="277" mass="29848" checksum="C7A91D9101D8297E" modified="2014-10-29" version="1">MNDVRRRYVIPGDKIVEGNYRPIMNVVRSGNALIATRIGIAEAGRDGVKVIPLSGVYIPRVNDLVIGKIVDHTSLSWEVDINSCFSANLPASDVFGRDFSPARDDMTKHLAIGDMITARVAAFDRTRDPMLTLQDRDLGKIPRGELLKISATRVPRLIGKRGSMIQTIEQATQTRVLIGQNGIVVVTGRSPEGIEQAVKAIRMVEDEAHTANLTQRIKVLLNVPDTPAAAEEAPPASSNGGSSGGGAPIPPPQQEATRADSSSETQQGKEMEVPDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MR41</accession>
    <name>A0A075MR41_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Probable endonuclease 4</fullName>
            <ecNumber evidence="7">3.1.21.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Endodeoxyribonuclease IV</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Endonuclease IV</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nfo</name>
        <name evidence="9" type="ORF">NTE_01963</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Endonucleolytic cleavage to 5'-phosphooligonucleotide end-products.</text>
            <dbReference type="EC" id="3.1.21.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 3 Zn(2+) ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the AP endonuclease 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.2" evidence="7"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MR41"/>
    <dbReference type="STRING" id="1459636.NTE_01963"/>
    <dbReference type="KEGG" id="nev:NTE_01963"/>
    <dbReference type="eggNOG" id="arCOG01894">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025885_0_1_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
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    <dbReference type="GO" id="GO:0008833">
        <property type="term" value="F:deoxyribonuclease IV (phage-T4-induced) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:phosphoric diester hydrolase activity"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.150:FF:000001">
        <property type="entry name" value="Probable endonuclease 4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AP_endonuc_2"/>
    </dbReference>
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        <property type="entry name" value="AP_endonuc_F2_Zn_BS"/>
    </dbReference>
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        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445:SF0">
        <property type="entry name" value="APURINIC-APYRIMIDINIC ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445">
        <property type="entry name" value="ENDONUCLEASE IV ENDODEOXYRIBONUCLEASE IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00518">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00730">
        <property type="entry name" value="AP_NUCLEASE_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00731">
        <property type="entry name" value="AP_NUCLEASE_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51432">
        <property type="entry name" value="AP_NUCLEASE_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylose isomerase-like TIM barrel" evidence="8">
        <location>
            <begin position="23"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF84021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="289" mass="30632" checksum="553F16B0FF37289B" modified="2014-10-29" version="1">MQMNGGYKVGFHVSIAGGISNSVDNAKGIGCSAFQIFSRNPRGWAAKPLAPNDVAAFRNKMAASGIDRTSTVVHMPYLPNLSGPSGEMYTKSVDTLAGEIQRAGELGIPYLVIHLGSHLGKGTEAGMGQLVNAITTARDKTKKKGEGVTVLLENNAGQKNSIGATFEELRTILDKLDGNDVGVCLDTCHAFASGYDLRTSEQVVKTLGAFDKSVGFKELKVVHLNDSKGALGSNLDRHEHIGLGNIGRAGIAAFLGHKAIAQLPIIMETPVDEKRDDAKNLKAFCELVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MR94</accession>
    <name>A0A075MR94_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02019</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MR94"/>
    <dbReference type="KEGG" id="nev:NTE_02019"/>
    <dbReference type="HOGENOM" id="CLU_2490275_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="86" mass="9888" checksum="3C0823604A4A5AA0" modified="2014-10-29" version="1">MRTIITFYNPDFLPAGRLARAIAVDMILMPRTESELERRIVRALEEYYALDFVSLLRLTTVSESALNKALESLKGKNIVDWFVVPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRI3</accession>
    <name>A0A075MRI3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA primase DnaG</fullName>
            <ecNumber evidence="9">2.7.7.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">dnaG</name>
        <name evidence="12" type="ORF">NTE_01634</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ssDNA + n NTP = ssDNA/pppN(pN)n-1 hybrid + (n-1) diphosphate.</text>
            <dbReference type="EC" id="2.7.7.101"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a ternary complex with MCM helicase and DNA. Component of the archaeal exosome complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the archaeal DnaG primase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.101" evidence="9"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700419.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRI3"/>
    <dbReference type="STRING" id="1459636.NTE_01634"/>
    <dbReference type="GeneID" id="41597410"/>
    <dbReference type="KEGG" id="nev:NTE_01634"/>
    <dbReference type="eggNOG" id="arCOG04281">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034626_0_0_2"/>
    <dbReference type="OrthoDB" id="8643at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000178">
        <property type="term" value="C:exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01029">
        <property type="entry name" value="TOPRIM_primases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00007">
        <property type="entry name" value="DNA_primase_DnaG_arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050219">
        <property type="entry name" value="DnaG_primase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020607">
        <property type="entry name" value="Primase_DnaG_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034154">
        <property type="entry name" value="TOPRIM_DnaG/twinkle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003108">
        <property type="entry name" value="PRK04031.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30313">
        <property type="entry name" value="DNA PRIMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30313:SF2">
        <property type="entry name" value="DNA PRIMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13662">
        <property type="entry name" value="Toprim_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56731">
        <property type="entry name" value="DNA primase core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1 9" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="9" id="KW-0271">Exosome</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2 9" id="KW-0639">Primosome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Toprim" evidence="11">
        <location>
            <begin position="171"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="271"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="283"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIF83695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="480" mass="52335" checksum="77A5EECBB799DF1D" modified="2014-10-29" version="1">MPSTGIVKYHVKLKFEVDGLVEKADIIGAIFGQTEGLLGPEMNLNELQKVSKVGRIEVNVETKGNVAKGDALIPMSTDISTAALIAAAIESIDKVGPFQAKFQLMGIDDIRAIKKKVIVDRAKKIVQDWATKTISEGEEMLKDVYDASKPGKLTAYGKAQLACGTGVFDSEWIILVEGRADVINLLRAGYDNAIAIEGAKIDETVVKLTEGKKVIAFLDGDRAGDLILKELAGVVKIDKVLRAPTGREVEECTPLEVSEILKDAYSVDVSAAPHQQELPPVQQEERRHERRDRDDRGGGYGGRRDRDRGGYGGRRDRDRGGYRDRDRGGYRDRDDRGGGYGGRRDDYQDREESYSHGPSQQEEPAQAPVTPGQPSAAAANDAPELLTAIRDVYPQINETLEAVILDGSMKQLLKVPVSEVIKRLDSAEGAKYLVIDGIVTQRLVEAADKAGIEYVVGHRTTGVKPSDIKVRTFGDVGITN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRK2</accession>
    <name>A0A075MRK2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02116</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700794.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRK2"/>
    <dbReference type="STRING" id="1459636.NTE_02116"/>
    <dbReference type="GeneID" id="41597845"/>
    <dbReference type="KEGG" id="nev:NTE_02116"/>
    <dbReference type="HOGENOM" id="CLU_2447523_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="89" mass="10143" checksum="826D5AE96DDE4BA5" modified="2014-10-29" version="1">MRENKDDDITIEFDLNEGLSFCTCVWVVYGGVVHYAQREDSTGKTETVCGIKDFQTHKTKGDKSDTTIRRLCKDCAEQFEVIEGQVCEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRL1</accession>
    <name>A0A075MRL1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">OB-fold nucleic acid binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_02126</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700803.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRL1"/>
    <dbReference type="STRING" id="1459636.NTE_02126"/>
    <dbReference type="GeneID" id="41597854"/>
    <dbReference type="KEGG" id="nev:NTE_02126"/>
    <dbReference type="eggNOG" id="arCOG01510">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110881_2_2_2"/>
    <dbReference type="OrthoDB" id="6262at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010212">
        <property type="term" value="P:response to ionizing radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04491">
        <property type="entry name" value="SoSSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048970">
        <property type="entry name" value="OB_Ssb-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051231">
        <property type="entry name" value="SOSS-B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13356">
        <property type="entry name" value="OB FOLD NUCLEIC ACID BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13356:SF0">
        <property type="entry name" value="SOSS COMPLEX SUBUNIT B HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21473">
        <property type="entry name" value="OB_Ssb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Single-stranded DNA binding protein Ssb-like OB fold" evidence="2">
        <location>
            <begin position="6"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF84181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="95" mass="10025" checksum="64CB8A7257C26303" modified="2014-10-29" version="1">MKISELKPGMRNVSVTAKVDSVGQPRTVNLKAGGTNTVADAIISDDSGSIKLSLWGDDINKIQAGDRISVENGYINTFKGENSISVGKFGKLTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRN9</accession>
    <name>A0A075MRN9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700822.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRN9"/>
    <dbReference type="STRING" id="1459636.NTE_02152"/>
    <dbReference type="GeneID" id="41597877"/>
    <dbReference type="KEGG" id="nev:NTE_02152"/>
    <dbReference type="eggNOG" id="arCOG01055">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_160435_0_0_2"/>
    <dbReference type="OrthoDB" id="9844at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038723">
        <property type="entry name" value="ArnR1-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14947">
        <property type="entry name" value="HTH_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ArnR1-like winged helix-turn-helix" evidence="1">
        <location>
            <begin position="6"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="99" mass="11696" checksum="5754AD06C0B11199" modified="2014-10-29" version="1">MVHEYRDRIYIRKDIMLKLSEYGELNQSKLMSYCGLNNVKHRVIIDDMVEKGLLTRFEELWGNKTIIKYKLSEKGRAILNEILEPYEALFPRESGGKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRT2</accession>
    <name>A0A075MRT2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Preprotein translocase subunit SecG</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 12">Protein transport protein Sec61 subunit beta homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">secG</name>
        <name evidence="14" type="ORF">NTE_01468</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Involved in protein export. The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. Can form oligomers of the heterotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cell membrane</location>
            <topology evidence="1 12">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the SEC61-beta family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700289.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRT2"/>
    <dbReference type="STRING" id="1459636.NTE_01468"/>
    <dbReference type="GeneID" id="41597261"/>
    <dbReference type="KEGG" id="nev:NTE_01468"/>
    <dbReference type="eggNOG" id="arCOG02957">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_208205_3_2_2"/>
    <dbReference type="OrthoDB" id="43651at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00751">
        <property type="entry name" value="SecG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023531">
        <property type="entry name" value="Preprot_translocase_SecG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016482">
        <property type="entry name" value="SecG/Sec61-beta/Sbh"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002318">
        <property type="entry name" value="PRK01253.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03911">
        <property type="entry name" value="Sec61_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0811">Translocation</keyword>
    <keyword evidence="6 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="topological domain" description="Cytoplasmic" evidence="12">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AIF83532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="56" mass="5872" checksum="2EF1037163C8465A" modified="2014-10-29" version="1">MSSKKKNAPLPASSAGLLRFFEDETKGIKVKPEIVMAIAGAMIGISVAIRIIFPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MS40</accession>
    <name>A0A075MS40_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF1512 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_02288</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_075055977.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MS40"/>
    <dbReference type="STRING" id="1459636.NTE_02288"/>
    <dbReference type="GeneID" id="41598003"/>
    <dbReference type="KEGG" id="nev:NTE_02288"/>
    <dbReference type="eggNOG" id="arCOG04181">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062565_0_0_2"/>
    <dbReference type="OrthoDB" id="15121at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009995">
        <property type="entry name" value="DUF1512"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056461">
        <property type="entry name" value="DUF1512_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056460">
        <property type="entry name" value="DUF1512_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07431">
        <property type="entry name" value="DUF1512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23542">
        <property type="entry name" value="DUF1512_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016495">
        <property type="entry name" value="UCP016495"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1512" evidence="2">
        <location>
            <begin position="30"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1512" evidence="3">
        <location>
            <begin position="210"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF84341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="384" mass="41957" checksum="E04EA3E2C2C5084C" modified="2014-10-29" version="1">MLDFFSVLFGQLGGLTDPGEFDPANPLVWVYIISLAIIPFFMMYGQKMQSKVILGEVSKSLVKLKDMKDGARRDAIDYVKSVIQDKAADPSAKIDKFLEYFTIMPVDMDPSGVVRKVEHVIRTKDERMRAEVRKICPGVGDYELSKIENILEAATALNMIYKVVRHYFLMGKRTTSMFVLVQLQMVMPLLIEEATAMKKAMGAFEKGQPIGDGIGPMVVGRMMLGKEKMPAAKETVYAEGEHAGRKLYLLKAEGPSGTVGRPGEAISRLVGDLGIKIDAIVMIDAALKLEGEKTGDVAEGIGAAIGGIGVEKYQIEEVATRFEIPLYAVIVKQSVQDAITVMRKEIADSFAKVTDTVHAIIEDKTEEGQSVLVIGVGNTMGVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MS93</accession>
    <name>A0A075MS93_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02384</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MS93"/>
    <dbReference type="STRING" id="1459636.NTE_02384"/>
    <dbReference type="KEGG" id="nev:NTE_02384"/>
    <dbReference type="HOGENOM" id="CLU_2313651_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="99" mass="11708" checksum="7052ECBB2EC3020E" modified="2014-10-29" version="1">MRIIPSTILSVLCKKYFIFQDIEKYSVYTFTIERFVFHHPTLDTLVRHPTTYQNPFSYTGNSWDHFPGLLTSRYELVTWGDKSRKLIYAVAIIIEGTRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MS96</accession>
    <name>A0A075MS96_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hydrocarbon binding protein (Contains V4R domain)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385444.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MS96"/>
    <dbReference type="STRING" id="1459636.NTE_02389"/>
    <dbReference type="GeneID" id="41598099"/>
    <dbReference type="KEGG" id="nev:NTE_02389"/>
    <dbReference type="eggNOG" id="arCOG01688">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105305_0_0_2"/>
    <dbReference type="OrthoDB" id="371687at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004096">
        <property type="entry name" value="V4R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35090">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35090:SF1">
        <property type="entry name" value="SLR0144 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02830">
        <property type="entry name" value="V4R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00989">
        <property type="entry name" value="V4R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4-vinyl reductase 4VR" evidence="1">
        <location>
            <begin position="120"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="187" mass="20621" checksum="E5789923DA793637" modified="2014-10-29" version="1">MSGGSTDPASIGSGENPFYHFSQKTKVIEDSAFGCRAILVNERFWNKIRSSILDLLKDAGPLVMYELGLEYGFDMGFQGKAKSKTRGNDIDFFTYYVLMSGWGRFEVSELKLKDNAPPRKATVKVHDSFFAKAAKSETGNPSCFFLSGLLAGMAEGTFSTGYNCLETKCLACGDDYCEFVLTRRPGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSA9</accession>
    <name>A0A075MSA9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DnaJ-class molecular chaperone with C-terminal Zn finger domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_01942</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSA9"/>
    <dbReference type="STRING" id="1459636.NTE_01942"/>
    <dbReference type="KEGG" id="nev:NTE_01942"/>
    <dbReference type="eggNOG" id="arCOG02846">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1792030_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051948">
        <property type="entry name" value="Hsp70_co-chaperone_J-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44360">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44360:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="8"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF84000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="144" mass="16545" checksum="27507684BC04C580" modified="2014-10-29" version="1">MATYQVSNYYEVLGLKPGASQEEIKKSFRSLAMKYHPDKNKGSEESKQKFMKIVEAYEVLSDTQSRKKYDENAFSVSTHAEWTPSADFARVYSYEELKRQYRQGGNIRGGMWDISDKASMGMWKATMILFAGLAAIVIYILILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSD6</accession>
    <name>A0A075MSD6_9ARCH</name>
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        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01972</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSD6"/>
    <dbReference type="STRING" id="1459636.NTE_01972"/>
    <dbReference type="KEGG" id="nev:NTE_01972"/>
    <dbReference type="eggNOG" id="arCOG01055">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_159725_1_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038723">
        <property type="entry name" value="ArnR1-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14947">
        <property type="entry name" value="HTH_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ArnR1-like winged helix-turn-helix" evidence="1">
        <location>
            <begin position="14"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="80" mass="9121" checksum="F4FB7A51D675E0C7" modified="2014-10-29" version="1">MFYEILCAIEDDAAHNEVARPTHVQHSTRLSYDKMMNHFSELEVKGMIHRVSGLVAITAKGKKFVEQYDELTRLIESAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSJ7</accession>
    <name>A0A075MSJ7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_02043</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSJ7"/>
    <dbReference type="STRING" id="1459636.NTE_02043"/>
    <dbReference type="KEGG" id="nev:NTE_02043"/>
    <dbReference type="eggNOG" id="arCOG03911">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2165347_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018649">
        <property type="entry name" value="SHOCT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09851">
        <property type="entry name" value="SHOCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="SHOCT" evidence="2">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF84100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="134" mass="15511" checksum="CAE70F44D4DE676C" modified="2014-10-29" version="1">MKYHMSNQESIRTRRIVAGALIGLTAIVVAVSIAAPFFAARQSGAFYSYYYYPYHHPFFFPFHFGWFGGIGILLPILVILLIAGWLLWPSRRYQSEDLRQHSDNAASILRERYAKGEITREQFESMMRDLKQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSK8</accession>
    <name>A0A075MSK8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01716</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700485.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSK8"/>
    <dbReference type="STRING" id="1459636.NTE_01716"/>
    <dbReference type="GeneID" id="41597485"/>
    <dbReference type="KEGG" id="nev:NTE_01716"/>
    <dbReference type="HOGENOM" id="CLU_2911319_0_0_2"/>
    <dbReference type="OrthoDB" id="9625at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="61" mass="6982" checksum="E7A30CB92BDF3009" modified="2014-10-29" version="1">MKEFRVLVTCNVCGETFDSDYKLMKHVSKSHPQPEKTGWMGSEDEHNCSCGGGHMHNHHHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSQ9</accession>
    <name>A0A075MSQ9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700802.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSQ9"/>
    <dbReference type="STRING" id="1459636.NTE_02125"/>
    <dbReference type="GeneID" id="41597853"/>
    <dbReference type="KEGG" id="nev:NTE_02125"/>
    <dbReference type="eggNOG" id="arCOG08805">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100103_1_0_2"/>
    <dbReference type="OrthoDB" id="9412at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="Ribbon-helix-helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="172" mass="19382" checksum="DF51BCD0CF397FB0" modified="2014-10-29" version="1">MSENDNVSITFRVDSRRVDQLRIIAAEQGMSLNLLVSHILSSYLEWESIAPKAGLAIVQKEVIKAFVNQMGDDELKKTAIKAADSFLETLLLMTGKKDVDSVLFVLRSKFKRSGFTIRSFEETDGRKILVQHDMGNKVSIFFKMYVERLINNAGSPVKIDTTDKSLIIEIPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSR9</accession>
    <name>A0A075MSR9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phage integrase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02577</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226986982.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSR9"/>
    <dbReference type="STRING" id="1459636.NTE_02577"/>
    <dbReference type="GeneID" id="68225777"/>
    <dbReference type="KEGG" id="nev:NTE_02577"/>
    <dbReference type="eggNOG" id="arCOG01245">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049414_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="448" mass="51703" checksum="2B0FC5BB43727F0B" modified="2014-10-29" version="1">MAQTFVQRKSRLRVKGLKVKDKEKIKEAITISIQNGNYTTRDIGVDVGKDHSTVSRYLTEMEKDGKWGIKRDANGNIVISLQKQIARRYQKLENEPFNQLPSIQKWVTFLKSGAIPANRINHLANVIHGISNQLKVMPETLVSYGVPIDATKRKEIAIEYWQNFLAWFNTAYPQMQKTNTINAYRSFLAAHNINFAHGEGKRYGLSTTSERLGEYKDILLTPEQIYRINKKLENENDWDSWSFMNIDLHTGARAFAMASMSRDRIAFSPLFRVEQFESKTKRGDWYLDKEGKWWVKYPTEECRAVVEIAYDSLPKCRKFLFFEDAKSDKANCLQASYFMHKMAVKFKKIFGELDKASWLNEKTRIYALGDGLYFTGHPLHLFRHTMAQYYLAATNWSLAYVASLGGWENTEVLNKCYGGIPEHIKAQVAKSVHVKFDSLDLGTARIII</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSS6</accession>
    <name>A0A075MSS6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01771</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSS6"/>
    <dbReference type="STRING" id="1459636.NTE_01771"/>
    <dbReference type="KEGG" id="nev:NTE_01771"/>
    <dbReference type="HOGENOM" id="CLU_887400_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="313" mass="36077" checksum="12D8677B8E9B7786" modified="2014-10-29" version="1">MPRIELPLVNYTALPPPLPKSAVTWGASSKDAIIQLLNEGRSVEEICNTTGNRRTFVKTVAYRFNHPEEFIVSQPVRSVESSRRLNHRSDIVCKGCGTTFSVPNCQRDAIKFCTRECRRTYWDARKVKVQAVPKERVRKKTHTIVCKNCGKQATVLKPTNAFCDQHCYFQFKRNSKKAPTYTHVCRHCNNEFGSWVKNRVYCSAKCRLEHTWKPAFEGQLSRDQKPICRNCHQPFKVGNNQNIYCSWACFKAYPHKTTKRKVIRSREMACVVCAKTFRVFPSHDGRKTCSMACYNKIRRSRHAPPLQAPQASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSX0</accession>
    <name>A0A075MSX0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl14</name>
        <name evidence="6" type="ORF">NTE_01827</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700580.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSX0"/>
    <dbReference type="STRING" id="1459636.NTE_01827"/>
    <dbReference type="GeneID" id="41597592"/>
    <dbReference type="KEGG" id="nev:NTE_01827"/>
    <dbReference type="eggNOG" id="arCOG04095">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095071_3_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00337">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.150.20:FF:000007">
        <property type="entry name" value="50S ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_uL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019972">
        <property type="entry name" value="Ribosomal_uL14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_uL14_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006344">
        <property type="entry name" value="PRK08571.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="50S/60S RIBOSOMAL PROTEIN L14/L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761:SF8">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00049">
        <property type="entry name" value="RIBOSOMAL_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF83887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="146" mass="15649" checksum="2E5D9B1BC41F5012" modified="2014-10-29" version="1">MAAGAKSRAVSAKGVEEFRPYITRALPVTAELVCADNTGAKVLRIAQVTRYKGRHSRQPAAAVGDFVTVTVKKGPAELRKQIFGAVIVRQKYPIRRPNGVRVAFEDNAAVLVTPEGEIKGTDIKGPVASEAAEKWPRIANLAGMIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTH8</accession>
    <name>A0A075MTH8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nitrosopumilus output domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02361</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700993.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTH8"/>
    <dbReference type="STRING" id="1459636.NTE_02361"/>
    <dbReference type="GeneID" id="41598077"/>
    <dbReference type="KEGG" id="nev:NTE_02361"/>
    <dbReference type="HOGENOM" id="CLU_2379517_0_0_2"/>
    <dbReference type="OrthoDB" id="372688at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.200">
        <property type="entry name" value="Protein of unknown function DUF3227"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021609">
        <property type="entry name" value="NitrOD5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044908">
        <property type="entry name" value="NitrOD5-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11537">
        <property type="entry name" value="NitrOD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitrosopumilus output" evidence="1">
        <location>
            <begin position="4"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="94" mass="10743" checksum="3D8683D44BD72975" modified="2014-10-29" version="1">MKEIMDAVTDTFSIFGPNTSKVLMFHLENQFGLKPKDIPDKPERFHAILQQLFGNYAASLEVAICKQIRNSNPSHNSEFVRFLEHHSLQEVKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTJ9</accession>
    <name>A0A075MTJ9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTJ9"/>
    <dbReference type="STRING" id="1459636.NTE_02386"/>
    <dbReference type="KEGG" id="nev:NTE_02386"/>
    <dbReference type="HOGENOM" id="CLU_3394434_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="31" mass="3683" checksum="66E249167DD78221" modified="2014-10-29" version="1">MRRIHLAGDHSNNKMERMNGEIRDRERSCVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTL4</accession>
    <name>A0A075MTL4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTL4"/>
    <dbReference type="STRING" id="1459636.NTE_02060"/>
    <dbReference type="KEGG" id="nev:NTE_02060"/>
    <dbReference type="HOGENOM" id="CLU_3338262_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="37" mass="4048" checksum="6B65576109C77994" modified="2014-10-29" version="1">MTAALVRINSSKINDRQEDFGTEAQGKLLPTNLSEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTR5</accession>
    <name>A0A075MTR5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Asparagine--tRNA ligase</fullName>
            <ecNumber evidence="2 8">6.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NTE_02976</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.22" evidence="2 8"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701484.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTR5"/>
    <dbReference type="STRING" id="1459636.NTE_02976"/>
    <dbReference type="GeneID" id="41598647"/>
    <dbReference type="KEGG" id="nev:NTE_02976"/>
    <dbReference type="eggNOG" id="arCOG00407">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004553_2_0_2"/>
    <dbReference type="OrthoDB" id="5908at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004816">
        <property type="term" value="F:asparagine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006421">
        <property type="term" value="P:asparaginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00776">
        <property type="entry name" value="AsxRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004522">
        <property type="entry name" value="Asn-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00457">
        <property type="entry name" value="asnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003037">
        <property type="entry name" value="PRK03932.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF34">
        <property type="entry name" value="ASPARAGINE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="9">
        <location>
            <begin position="124"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="NCBIfam" id="TIGR00457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIF85011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="432" mass="48928" checksum="0DCC669AB542F8CF" modified="2014-10-29" version="1">MRASEVKNAGFVGKEVTIRGWVHRLRKQKENSFILLRDDRGAVIQCVLPTDKVANLTIESSVQITGTVSQDPRAPEGGFEIKGKELKIFNIAEEYPIGEYQSDELLLDKRHLALRTRKMIAIAKVRASVLHYGRRWFVENGWMEVTAPTIVKGAVEGGSTLFKLRYFDQDAYLSQSAQLYLEAMIFSLGPVWSLTPSFRAEKSRTVRHLAEFSHLEAEAPWVTLEDILKVEEQLVSYVIQNTLKERAEELEFLKRDVSGLKKVEPPFERLPYGRAIEILRSKGFEVTEDDGTRRGIQFGDDLSIDSERELTKDADKPVFVVGYPISVKPFYVKEDPEHPGVGLTADMLAPSGFGEITSGGQREDSIDSITSRMLKEGLKPEAYEWYLDLRRYGSVPHGGFGLGIERLVRWITNAEDIKDTVLFPRTMSRVEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MU46</accession>
    <name>A0A075MU46_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator, AsnC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_02630</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701203.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MU46"/>
    <dbReference type="STRING" id="1459636.NTE_02630"/>
    <dbReference type="GeneID" id="41598323"/>
    <dbReference type="KEGG" id="nev:NTE_02630"/>
    <dbReference type="eggNOG" id="arCOG01580">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091233_5_4_2"/>
    <dbReference type="OrthoDB" id="6762at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043200">
        <property type="term" value="P:response to amino acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30154">
        <property type="entry name" value="LEUCINE-RESPONSIVE REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30154:SF34">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR AZLB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13412">
        <property type="entry name" value="HTH_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF84673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="147" mass="16725" checksum="348177200FC2859F" modified="2014-10-29" version="1">MDKTDVKILEKMLSDARMSYRKIAEEIGVSPPTVLARVEKLEKEGIVKSYSALLDHEKLGYDLTAIIDITAAKGKIIEIEKQIAKFPNVCAVYDITGLTDMTVIAKFRNRKELSNFVKKDLSLQYVERTNTHVVLITVKEDFRFVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MU73</accession>
    <name>A0A075MU73_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Small G protein, GTPase SAR1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_02213</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700873.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MU73"/>
    <dbReference type="STRING" id="1459636.NTE_02213"/>
    <dbReference type="GeneID" id="41597934"/>
    <dbReference type="KEGG" id="nev:NTE_02213"/>
    <dbReference type="eggNOG" id="arCOG01225">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037460_3_0_2"/>
    <dbReference type="OrthoDB" id="31092at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF8">
        <property type="entry name" value="GPN-LOOP GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF84267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="251" mass="26947" checksum="70B27F6C1486D73F" modified="2014-10-29" version="1">MVNAIFVTGTAGSGKSLLTSRLLQWYRDTGAYPTTLNLDPGAVTLPYEPDIDIRNYIDIGTLMESYGLGPNGALIMASDLMATRLDEIQQEVDEANPDYLIVDTPGQIELFAFRASGPYFISNLQADNKATVFAFDGTLVSSPINFVSISLLASAVKLRLKTAQINVLTKRDLVIERLKDILDWAASTQALESALSGEKDAEYSLLSKDLSRSMTRAGFAPGLVAVSSTTMNGLVNVAAALARTLNQGEDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUE7</accession>
    <name>A0A075MUE7_9ARCH</name>
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        <recommendedName>
            <fullName evidence="2">PepSY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_03252</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUE7"/>
    <dbReference type="KEGG" id="nev:NTE_03252"/>
    <dbReference type="HOGENOM" id="CLU_102442_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025711">
        <property type="entry name" value="PepSY"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03413">
        <property type="entry name" value="PepSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PepSY" evidence="2">
        <location>
            <begin position="157"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF85281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="270" mass="27786" checksum="0E5364825AEC8C32" modified="2014-10-29" version="1">MMSSLTGNKKLLVPVLLVAVLAMASIAALPFAAFAQTTTDEDEDNNSNDTLTAPENNNSTAATNSTETNQLDNSTATDQMDNSTATDQEGITGQADNSTATEGNSTLTAPEENNSTMTAPEENATTTGAEDTSGIVGTIIVNSTMSADDFDEGSLAVPQSNATQIAAAQVTNGTVVDSQLDVVQGFLVYTVTVVDVANHNVYHVIVDPGDGNILYTSPGIPAGNSDIEDAMEESGGSSNGGGNSDDDDDDHGGHHSHDDDDDDDDSSCDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUF0</accession>
    <name>A0A075MUF0_9ARCH</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03257</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
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            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701717.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUF0"/>
    <dbReference type="STRING" id="1459636.NTE_03257"/>
    <dbReference type="GeneID" id="41598912"/>
    <dbReference type="KEGG" id="nev:NTE_03257"/>
    <dbReference type="HOGENOM" id="CLU_2299439_0_0_2"/>
    <dbReference type="OrthoDB" id="7241at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="104" mass="12146" checksum="B6932486054431F5" modified="2014-10-29" version="1">MKVRVYFCREEAADIDLASARISRQALETIYDLVWEHELKNVITIGKIWLRFQQSRSRPFGHPLKEKRPHATIAAGDIIQAAEDRYYMVMDVGVKEIKLREEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUG0</accession>
    <name>A0A075MUG0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_02711</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701269.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUG0"/>
    <dbReference type="STRING" id="1459636.NTE_02711"/>
    <dbReference type="GeneID" id="41598401"/>
    <dbReference type="KEGG" id="nev:NTE_02711"/>
    <dbReference type="eggNOG" id="arCOG08661">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075307_0_0_2"/>
    <dbReference type="OrthoDB" id="8216at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038762">
        <property type="entry name" value="ABM_predict"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40057">
        <property type="entry name" value="SLR1162 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40057:SF1">
        <property type="entry name" value="SLR1162 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="ABM" evidence="2">
        <location>
            <begin position="16"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF84753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="194" mass="22515" checksum="8528314C20DA4189" modified="2014-10-29" version="1">MHPHPQNNDHGANDPVTVIVTRKAKKGRIKEFEEWMDGIIHEAMKFEGHMGVHIIRPSDPPLNREYVIIFRFNTYENLAKWERSEIRKEWLKKSRDVTEGEPKVEMQTGLEFWFTPSSGSLAVPPRYKMAMVTGAVIFVLLSILVPQIQLATKDLPFQFRTLVVVAIMVLLMTYVVMPSVTRLLRPWLFKKTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUG3</accession>
    <name>A0A075MUG3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUG3"/>
    <dbReference type="STRING" id="1459636.NTE_02805"/>
    <dbReference type="KEGG" id="nev:NTE_02805"/>
    <dbReference type="HOGENOM" id="CLU_2930322_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="62" mass="6432" checksum="B350B5EAF1FDEEB9" modified="2014-10-29" version="1">MLDHVRNVTLIIVITALMAFGLIGVTLLVDLLPIPAMHAASSSTTAAANIVDQVALKSGFTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUR7</accession>
    <name>A0A075MUR7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_02365</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUR7"/>
    <dbReference type="STRING" id="1459636.NTE_02365"/>
    <dbReference type="KEGG" id="nev:NTE_02365"/>
    <dbReference type="HOGENOM" id="CLU_1922678_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF84417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="131" mass="13999" checksum="DA2F535E5C6EA793" modified="2014-10-29" version="1">MVDEVRLAALVVIVTVAIPVFLITSGAKTMLSGFSLPVPRSAVAMSSDSNSNPPSSSSVEHFAKNNPEQALYAMYDSQAAEELDRCYDSSSDKELCDGSVDLIVDSCTNSQVDLTVCHDPRIEQIVASKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUV1</accession>
    <name>A0A075MUV1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thermosome subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NTE_02950</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701464.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUV1"/>
    <dbReference type="STRING" id="1459636.NTE_02950"/>
    <dbReference type="GeneID" id="41598626"/>
    <dbReference type="KEGG" id="nev:NTE_02950"/>
    <dbReference type="eggNOG" id="arCOG01257">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008891_7_3_2"/>
    <dbReference type="OrthoDB" id="9362at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03343">
        <property type="entry name" value="cpn60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012714">
        <property type="entry name" value="Thermosome_arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02339">
        <property type="entry name" value="thermosome_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF84985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="545" mass="58431" checksum="6491A4FDE976E8BE" modified="2014-10-29" version="1">MSVQENTIPVVLLKEGTSETRGYQAQRNNITAAKTIAEIVRTSLGPRGMDKMLVDTLGDVTITNDGATILKEIDIQHPAAKMMVEISKATDSEVGDGTTSTVVLAGALLENAEELIAKDVHPTVIIEGYDRAAERAVAILREVADKVNIEDKDSLVKIAQTAMASKLVSFDEGHLSRLVVDAVLAVAEKAGNHGSSGDNHLKVDIDSIKVEKKAGGSIRDTKLVKGIILDKEVVHGEMPKRIENARIALLNCPLEIEKTEFDAKISIESPEQMQKFLDEENSVLKSMVDKISSAGANVVVCQKGIDDMAQHYLAKAGILAVRRAKESDMNNLAKSTGGKVLANVEDLAADDLGHAQLVQERKIESDKWVFIEGCKNPKAVSILVRGGSQRVIDEAERSVHDAIMVVKDVLEYPYVLVGAGAPEGVVSQRLREWSGSLSGRPQLAAEKFADSVERVAMVLAENAGMDPLDTQVQLRAKASSAKPRFGIDVINGKVADMAAKGIYEPLKVKEQVINAATEAACMILHVDDIVAAASPKQGGTSTPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUV4</accession>
    <name>A0A075MUV4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4367 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUV4"/>
    <dbReference type="STRING" id="1459636.NTE_01005"/>
    <dbReference type="KEGG" id="nev:NTE_01005"/>
    <dbReference type="HOGENOM" id="CLU_1149774_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="241" mass="26278" checksum="91E7C505F6A22D68" modified="2014-10-29" version="1">MRMAAGEPSREKLPSAAWAATIPVAAGLATGILFVLIFSVYATGSQDARPRDREITWYNDNGEIACGQPIEIVKARAPFAVPLPTALPAGYSLQYADYSGVKEVFMEFYNSTICGGDGPKSLHDGTIEIRIDPFSERIAGTNAAERIDGSQYTEGRFQTLQNAGSIDARKYAFSDGNRHAVGYNAGTGTSVAVDENNVTIHAEQYDYPSSLWVVDDEKDIIYRLEAHMPIDELARIAESMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MV41</accession>
    <name>A0A075MV41_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SnoaL-like polyketide cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03081</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MV41"/>
    <dbReference type="STRING" id="1459636.NTE_03081"/>
    <dbReference type="KEGG" id="nev:NTE_03081"/>
    <dbReference type="eggNOG" id="arCOG06513">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3093927_0_0_2"/>
    <dbReference type="OrthoDB" id="113947at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030638">
        <property type="term" value="P:polyketide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009959">
        <property type="entry name" value="Cyclase_SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07366">
        <property type="entry name" value="SnoaL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="51" mass="5741" checksum="66F4A82ACF0DDB3E" modified="2014-10-29" version="1">MKGFGGRMIQPPNKKFRIEFCTVAHWKGGKITEERLFYDLMGMTGPIGAPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MV51</accession>
    <name>A0A075MV51_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701580.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MV51"/>
    <dbReference type="STRING" id="1459636.NTE_03096"/>
    <dbReference type="GeneID" id="41598757"/>
    <dbReference type="KEGG" id="nev:NTE_03096"/>
    <dbReference type="HOGENOM" id="CLU_1529154_0_0_2"/>
    <dbReference type="OrthoDB" id="9132at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="175" mass="20445" checksum="5E4CA1C85DBDB6DC" modified="2014-10-29" version="1">MKDKPQDMFNMDVFGRQFAMRTIHVTSAASTFIFAMVYGVIEHTLLTSSLGISILVHPLSVHIVGQIFFYHVLMFILAVLISFNPFFDILFFASTRTVKKQALLWGTGNILNFIWLEDLFYWVLFGEWPKDVMTPLHLSFYGIVWWYPVALFSASFLYYLTIRSMRKMKESVNDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MV77</accession>
    <name>A0A075MV77_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03126</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701605.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MV77"/>
    <dbReference type="STRING" id="1459636.NTE_03126"/>
    <dbReference type="GeneID" id="41598786"/>
    <dbReference type="KEGG" id="nev:NTE_03126"/>
    <dbReference type="HOGENOM" id="CLU_2285142_0_0_2"/>
    <dbReference type="OrthoDB" id="6353at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="103" mass="12337" checksum="248E163B1D3C7175" modified="2014-10-29" version="1">MTIMMITLRQDLDAVSDVLRQTFAIEPFKRDYDTAFSAIAEILYRYGMAENPRNLRFRFILCMQEFFDGIPQDQWRVKDPAFVKQSEEFAIAKFREWILEQIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVC6</accession>
    <name>A0A075MVC6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03178</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701646.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVC6"/>
    <dbReference type="STRING" id="1459636.NTE_03178"/>
    <dbReference type="GeneID" id="41598836"/>
    <dbReference type="KEGG" id="nev:NTE_03178"/>
    <dbReference type="HOGENOM" id="CLU_1912245_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="132" mass="15339" checksum="8FA0D0E62A6DBB82" modified="2014-10-29" version="1">MPKSDIFDDDQEEKGWTKRNPEFEDKLGDLIISEYQADRIRAGLARKVEGYRHKAAGYYYQDNDKGSPSSTCEFRYKGKLLKLTIKVDEIAIPDQRSSRARRGLQRLVRSLSEKKKNNSNKKILAKTEKEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVE6</accession>
    <name>A0A075MVE6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribonuclease P protein component 4</fullName>
            <shortName evidence="8">RNase P component 4</shortName>
            <ecNumber evidence="8">3.1.26.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Rpp21</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rnp4</name>
        <name evidence="9" type="ORF">NTE_03109</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.</text>
            <dbReference type="EC" id="3.1.26.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Consists of a catalytic RNA component and at least 4-5 protein subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the eukaryotic/archaeal RNase P protein component 4 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.5" evidence="8"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701590.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVE6"/>
    <dbReference type="STRING" id="1459636.NTE_03109"/>
    <dbReference type="GeneID" id="41598769"/>
    <dbReference type="KEGG" id="nev:NTE_03109"/>
    <dbReference type="eggNOG" id="arCOG04345">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079140_3_2_2"/>
    <dbReference type="OrthoDB" id="10058at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030677">
        <property type="term" value="C:ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.420">
        <property type="entry name" value="Immunoglobulin FC, subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00757">
        <property type="entry name" value="RNase_P_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016432">
        <property type="entry name" value="RNP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007175">
        <property type="entry name" value="Rpr2/Snm1/Rpp21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14742:SF0">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14742">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04032">
        <property type="entry name" value="Rpr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004878">
        <property type="entry name" value="RNase_P_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="7 8" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF85143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="98" mass="11151" checksum="E42B63A9582593E2" modified="2014-10-29" version="1">MARERIEILVAGALKEQDAALASRRAHLAKKIAMRHRVRMPYEIRQLYCKKCKAFIVPGRTARVRVGRSGTKAVRVTCALCGHTYRKVISKSSHYKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVF6</accession>
    <name>A0A075MVF6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Xaa-Pro aminopeptidase</fullName>
            <ecNumber evidence="6">3.4.13.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NTE_02604</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.13.9" evidence="6"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226986985.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVF6"/>
    <dbReference type="STRING" id="1459636.NTE_02604"/>
    <dbReference type="GeneID" id="41598297"/>
    <dbReference type="KEGG" id="nev:NTE_02604"/>
    <dbReference type="eggNOG" id="arCOG01000">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017266_4_2_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102009">
        <property type="term" value="F:proline dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01092">
        <property type="entry name" value="APP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050659">
        <property type="entry name" value="Peptidase_M24B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001131">
        <property type="entry name" value="Peptidase_M24B_aminopep-P_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46112">
        <property type="entry name" value="AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46112:SF2">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00491">
        <property type="entry name" value="PROLINE_PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase N-terminal" evidence="5">
        <location>
            <begin position="6"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24" evidence="4">
        <location>
            <begin position="134"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF84647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="356" mass="39336" checksum="C79321CA73B8EBB4" modified="2014-10-29" version="1">MTMKERRSRLLQHAATAGCSAVAAFEPENVFYLTGFWGEAIAVCTEDGTKLVAPKLEYSRAQQASVECEVIPTERGSELLSTFVSQIKNKKTCTDCSDYGTVEHIRKLQGDITVDTEPFFLTRRLKDEAEMKVIAKASRILDRLYEICADEIKAGMTERDLQAKLVYEGLKMGANPPSYKSTLNPLIIAGGPNGALPHAEVTDRKFKNKDMIVVDLTLRHQGYIADATRTFALGKPTAEMVHVYEIVQESQKAGLDAAVAGATCGQVDAACRDLIKERGYERQFIHSTGHGIGLDVHEPPWVRTKNEEVLQKNMAVTVEPGIYLEGKFGVRIEDSVLVTDGKPKVLNKFTKDLVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVF8</accession>
    <name>A0A075MVF8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01171</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700041.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVF8"/>
    <dbReference type="STRING" id="1459636.NTE_01171"/>
    <dbReference type="GeneID" id="41596983"/>
    <dbReference type="KEGG" id="nev:NTE_01171"/>
    <dbReference type="HOGENOM" id="CLU_2313650_0_0_2"/>
    <dbReference type="OrthoDB" id="382736at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="99" mass="11471" checksum="F47EE49A42186F41" modified="2014-10-29" version="1">MRLFGGEKKKFELGNGTVVEKFDPEKQCAWCGRRLNKDYRYSEGREFDGTIEELVKNYKINDYDIVTIGGRKIIGIMQNYHGRCANVMRGKIVAPIDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVH6</accession>
    <name>A0A075MVH6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bacterial regulatory protein, arsR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_02624</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVH6"/>
    <dbReference type="STRING" id="1459636.NTE_02624"/>
    <dbReference type="KEGG" id="nev:NTE_02624"/>
    <dbReference type="eggNOG" id="arCOG00731">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1521801_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="2">
        <location>
            <begin position="81"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF84667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="176" mass="19357" checksum="704757BFA8A7098B" modified="2014-10-29" version="1">MLAQSYANSGRYTVTLADAESTGPLDHPAATALYEYAPFTLPITWGAVAGTVIWRGRVRSQWSKQGYDYDTFKLITKMRGSPTRQKLLEAVRNEQKNKLQLANELGVDWKTIDNHVAMLLEARLVEEKNVVGTARYYSITENGAKVLALLASSGGEAKDDDDGSSRKEEVAGGDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVJ9</accession>
    <name>A0A075MVJ9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phage integrase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700085.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVJ9"/>
    <dbReference type="GeneID" id="41597030"/>
    <dbReference type="KEGG" id="nev:NTE_01222"/>
    <dbReference type="eggNOG" id="arCOG01245">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_682577_0_0_2"/>
    <dbReference type="OrthoDB" id="142231at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="370"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="443" mass="51762" checksum="DA3CABB0D08BEA63" modified="2014-10-29" version="1">MPDPLVQKYLDTIATQNVGSAKAVGYFIKDFETYAKDQLKMRVTELVKKLKDGTATDDPKEEQVYHIMKAYANWLVKNRFEDNGGSNNARTIKLKVSWARNFLEVNFIPISNAIFKQQVKYPKPEEPELSPAAKKTIQSIIIACEDIRLQTYAMWEASMGWRAKESFSIQNQHLEGLDLKTLKFTTNPTFVNVRGKHSKTKAGKRRQLTSEMRSQIEKWLAFKYRPRTINRQVLKNGKLVWNKKQVIPVPKPEDYVFAPYHEELVATLRALYKEAADRFRDLIDRLEIGYEEGGKRRKITLHTLRRYVFTACTKAVNEQYAKYHIGRKVHEYTKKTEEEIAEDFAGVEHLITFMDTSAIEEKQRSLVKELEVSQSRIRTLSEQLDILKTEKNSDVEVLKKQIAEMQKQRDKDMELFWKSERERGNVKTGLEELEEIETKKLQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVV2</accession>
    <name>A0A075MVV2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01366</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700207.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVV2"/>
    <dbReference type="STRING" id="1459636.NTE_01366"/>
    <dbReference type="GeneID" id="41597164"/>
    <dbReference type="KEGG" id="nev:NTE_01366"/>
    <dbReference type="eggNOG" id="arCOG14992">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_158386_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="131" mass="15087" checksum="936932C3ED54F998" modified="2014-10-29" version="1">MEETVSNISSTTPDKSLSATPETRKRKFIRLGRFDSMDKDSPNVLEVKPQTRQIYATEYSQCTDVSYKDNGIWIDAILPLRSNGSANVSLINQWSRGLDSGRIKIGKTVKILTWLDKSRNDRMIRRFRLVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVW0</accession>
    <name>A0A075MVW0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701278.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVW0"/>
    <dbReference type="STRING" id="1459636.NTE_02720"/>
    <dbReference type="GeneID" id="41598410"/>
    <dbReference type="KEGG" id="nev:NTE_02720"/>
    <dbReference type="HOGENOM" id="CLU_2010164_0_0_2"/>
    <dbReference type="OrthoDB" id="6177at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="123" mass="13570" checksum="BAB20857D9A4AEBF" modified="2014-10-29" version="1">MSTTTTSATIQEVVDKFNTLDDALKAAFPKVDPRLVVGLIIREKTEKRPIYTLETVIKPGQKIDSIRNDILNVTGMAPGFYLQNTKIIVTHALDLELLKRINDLDYVVSIKGSPYSAGGSSDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWC6</accession>
    <name>A0A075MWC6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">4-aminobutyrate aminotransferase family protein</fullName>
            <ecNumber evidence="6">2.6.1.19</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NTE_01521</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.19" evidence="6"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWC6"/>
    <dbReference type="STRING" id="1459636.NTE_01521"/>
    <dbReference type="KEGG" id="nev:NTE_01521"/>
    <dbReference type="eggNOG" id="arCOG00915">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_10_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034386">
        <property type="term" value="F:4-aminobutyrate:2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050103">
        <property type="entry name" value="Class-III_PLP-dep_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986:SF79">
        <property type="entry name" value="ACETYLORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986">
        <property type="entry name" value="AMINOTRANSFERASE CLASS III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF83584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="438" mass="46905" checksum="25AB0CEB8344BF52" modified="2014-10-29" version="1">MKKAPLPRFQVQPLNSTFGQDIFVKYAKISGELPGPIASDVIATMKKNCYDSTFTYPLVIASGSGCVVKDVDGNSFLDFTSNIGACPLGYSHPDVIGVIAEMSRNGAHKIAGQDFYCKEHADLAEQFVSVLPDGFKAFFINSGAEAVENAIKIAYRKGFAEGQPVLPGVSCTGAFHGRTLGALSFTYSKPVQKAGFPELAVLRIKFCTSDGDQEIDAIEKALAGNKVAFVLTEIVQGEGGYNIASQRFVQNLRDATKKHGVPLILDEVQSGMGRTGKWWAFEHYGVLPDIMSAAKALQVGATAYKSEYDPDQHGVLSSTWGGGSRIDLAVGATVIEVIKRDRLLANVLVMGERLKKGLADLAAGKKGIIDVRGLGLMIGIEFDTKENRDAVLMQAFRRGLLLLPAGQKAMRVIPPLVITAEEVDEGLELMATAAAASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWY9</accession>
    <name>A0A075MWY9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Precorrin isomerase</fullName>
            <ecNumber evidence="8">5.4.99.61</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NTE_01733</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CobH/CbiC family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.61" evidence="8"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWY9"/>
    <dbReference type="STRING" id="1459636.NTE_01733"/>
    <dbReference type="KEGG" id="nev:NTE_01733"/>
    <dbReference type="eggNOG" id="arCOG02246">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG02247">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_564543_0_0_2"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016993">
        <property type="term" value="F:precorrin-8X methylmutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1400">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10230">
        <property type="entry name" value="Cobalamin biosynthesis CobH/CbiC, precorrin-8X methylmutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002762">
        <property type="entry name" value="CbiX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003722">
        <property type="entry name" value="Cbl_synth_CobH/CbiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036588">
        <property type="entry name" value="CobH/CbiC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43588">
        <property type="entry name" value="COBALT-PRECORRIN-8 METHYLMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43588:SF1">
        <property type="entry name" value="COBALT-PRECORRIN-8 METHYLMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02570">
        <property type="entry name" value="CbiC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01903">
        <property type="entry name" value="CbiX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53800">
        <property type="entry name" value="Chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63965">
        <property type="entry name" value="Precorrin-8X methylmutase CbiC/CobH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC" evidence="7">
        <location>
            <begin position="272"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF83794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="483" mass="53543" checksum="5916C17C58918254" modified="2014-10-29" version="1">MKKRALLIVDRGSREPEVRQEMQEICALAKGKAGYDFADYCFLEVLPPFIEEGIKKCVDAGAEAITVMPYFLYPGMKLKDTVKQSARIGRDKNLNLVITRPLSYHPMMPELVSERIAELKKEKSISLSDSQCDVLLIGHGSSDRNAHDAFVHTAEAIKSRYRNVHHCFLELDTPNIEQGVMQAVARQPKVLLMMPYFLHKGAHIKRDVVNDVSAALEKARFQDAYMARHLGVDDKLVNLVVERAKEVENRQGPDDRSFGTAASRSMTERAFDIEKRSFEIIDSEVGPHDYDSMQWPIVRRVIHATADFDFAGKGKMLFHKRAIESAFFAIKNRCTIVTDVDMVLAAINKKSLSDLGLKGACYISDKSVAEQARRLGKTRSEMAMRHAAKEIEGGIVVVGNAPTALLEVISMVKEGVAKPALIVGIPVGFVSAPESKEALAKMTDDDDGVPFITNVGRKGGSPAASSIINALLLLYQNNSQRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MX57</accession>
    <name>A0A075MX57_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01818</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700574.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MX57"/>
    <dbReference type="GeneID" id="41597583"/>
    <dbReference type="KEGG" id="nev:NTE_01818"/>
    <dbReference type="eggNOG" id="arCOG05900">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1718128_0_0_2"/>
    <dbReference type="OrthoDB" id="9395at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="152" mass="17173" checksum="EC9262CCA5F6F77E" modified="2014-10-29" version="1">MSKDNEQAGSSNNDKIEEQLKGKTLQVYMYMIKRKEPVGVREVQRDLDFSSPSVANYHIDKLVQLALVGQDEYGRYYIIQKVQVGVLQAFVNIGGLAVPRLSFFAAFFTTMLIAYVVLNFNNLDVFAIGFAVAGAVAFWIETLRVWIKRPIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MX74</accession>
    <name>A0A075MX74_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glucose/sorbosone dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_03188</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701653.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MX74"/>
    <dbReference type="STRING" id="1459636.NTE_03188"/>
    <dbReference type="GeneID" id="41598844"/>
    <dbReference type="KEGG" id="nev:NTE_03188"/>
    <dbReference type="eggNOG" id="arCOG02796">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012253_0_0_2"/>
    <dbReference type="OrthoDB" id="6744at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012938">
        <property type="entry name" value="Glc/Sorbosone_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH_b-prop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19328">
        <property type="entry name" value="HEDGEHOG-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19328:SF13">
        <property type="entry name" value="HIPL1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07995">
        <property type="entry name" value="GSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="Soluble quinoprotein glucose dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose/Sorbosone dehydrogenase" evidence="2">
        <location>
            <begin position="58"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF85217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="371" mass="40033" checksum="F533A42B893AF4E8" modified="2014-10-29" version="1">MERDRRLALVAAVAIIIASVATIFFTPSSTTIPIPEPSSGGKNSTGISSGIKVVAENLNVPWAIDVAKDGRLFFTERSGAIRVVSANGTLLSDPAAYINVAQQGEAGLLGLALHPDFAQNHLLYIYQTYTNGTAVFNKVVMLTEKDNKIIDSKVVLDKIPAADRNDGGRIRFGPDGKLYIATGDAKQPELAQNAGSLAGKILRINPDGSIPEDNPFSGSPVYSYGHRNVQGLAWDLKGNMYATEHGESGNDEINLIKPGENYGWPVEECDAKRFEKPVMCFNPAVAPAGMTIAHFDKLGYKGDLLVASLKAMQLRKVDLENNTTTNILTSYGRIRDVVEAPDGTLYLLTSNRDGRAIPNPGDDKILHIQEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MX90</accession>
    <name>A0A075MX90_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AAA family ATPase, CDC48 subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NTE_03208</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. CDC48 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_075055334.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MX90"/>
    <dbReference type="STRING" id="1459636.NTE_03208"/>
    <dbReference type="GeneID" id="41598865"/>
    <dbReference type="KEGG" id="nev:NTE_03208"/>
    <dbReference type="eggNOG" id="arCOG01308">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_12_2_2"/>
    <dbReference type="OrthoDB" id="77269at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19519">
        <property type="entry name" value="RecA-like_CDC48_r1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19511">
        <property type="entry name" value="RecA-like_CDC48_r2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000007">
        <property type="entry name" value="AAA family ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000057">
        <property type="entry name" value="AAA family ATPase, CDC48 subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000018">
        <property type="entry name" value="Cell division control 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000012">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005938">
        <property type="entry name" value="AAA_ATPase_CDC48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004201">
        <property type="entry name" value="Cdc48_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003338">
        <property type="entry name" value="CDC4_N-term_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01243">
        <property type="entry name" value="CDC48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF171">
        <property type="entry name" value="NUCLEAR VALOSIN-CONTAINING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02933">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02359">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01072">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01073">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CDC48 N-terminal subdomain" evidence="7">
        <location>
            <begin position="7"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="CDC48" evidence="6">
        <location>
            <begin position="104"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="210"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="483"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF85237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="722" mass="79499" checksum="67D073CC85645098" modified="2014-10-29" version="1">MSQNTLSLKVLEAYTRDVGRGVARIDYDSMDSLGASTGDVIEIRGKRRTVAKCLPLYPSDEGKGIIRVDGLVRNNAGIAIGDTVTVKKIKAVPAEKVIVAPLEAIPPIDERYLADALESVPLIKGDNVMVPYFGGRLTFQVIGVTPAADAVLVTQKTIFHIAEKGETMRGVPQVTYEDIGGLKEEIQKVREMIELPLRHPEIFEKLGIEAPKGVLLYGPPGTGKTLLAKAVANESNAHFISISGPEIMSKFYGESEARLREIFKEAKEKAPSIIFIDEIDSIAPKREEVTGEVERRVVSQLLSLMDGLEARGKVIVIAATNRPNAIDPALRRPGRFDREIEIKVPDKRGRLEILQIHTRNMPLETDVDQDKIAGITHGFVGADLEYLCKEAAMKCLRRLLPELNLEDEKLSPDVLNKLIVTMSDFENAVKEVMPSAMREVYLESPDIPWTAIGGLDEVKRELQEAVEWPLRYPDLYTKLGHTMPKGILMHGPSGTGKTMLAKAVATESEANFISVRGPELLSKWVGESERGIREIFRRARQAAPCVVFFDEIDSIAPTRGMGGDSMVTERVVSQLLTELDGIQALSGVVVIAATNRADIIDPALLRPGRFDKIVFVPMPDKPTRLKILEIHAKKKPIGPDVDLGKVAELTDGFSGADTSSVVNTAVSLVLHEYLAKYPTPEEAAKHAAEAHVMMRHFEDAIKKIKTQREGKPGEKVTVPYYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MXG4</accession>
    <name>A0A075MXG4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">A-type ATP synthase subunit B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">atpB</name>
        <name evidence="12" type="ORF">NTE_03278</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the A-type ATP synthase that produces ATP from ADP in the presence of a proton gradient across the membrane. The B chain is a regulatory subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Has multiple subunits with at least A(3), B(3), C, D, E, F, H, I and proteolipid K(x).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MXG4"/>
    <dbReference type="STRING" id="1459636.NTE_03278"/>
    <dbReference type="KEGG" id="nev:NTE_03278"/>
    <dbReference type="eggNOG" id="arCOG00865">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022916_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18112">
        <property type="entry name" value="ATP-synt_V_A-type_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18118">
        <property type="entry name" value="ATP-synt_V_A-type_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01135">
        <property type="entry name" value="V_A-ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00310">
        <property type="entry name" value="ATP_synth_B_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022879">
        <property type="entry name" value="V-ATPase_su_B/beta"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003235">
        <property type="entry name" value="PRK04196.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389:SF4">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039114">
        <property type="entry name" value="V-ATPsynth_beta/V-ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="3 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 8" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="10">
        <location>
            <begin position="10"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="9">
        <location>
            <begin position="116"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase A/B type C-terminal" evidence="11">
        <location>
            <begin position="340"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF22919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIF85307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="443" mass="48632" checksum="AC23196DE67EB7F8" modified="2014-10-29" version="1">MVIDGITKASFDELVEIETAEGERRLGKVLEVGFGKAVVQVFEGTTGLTVSGTKAKFLGKTMEMPVSQELLGRVFDGLGRPNDGLPEPIADKFLDVNGEPMNPERREYPTSFIQTGVSVIDGMLTLVRGQKLPIFSGSGMPHNILAAQIARQASVVGTKEDFAVVFAAIGVQYSEAQYFKRSLEESGALRRSVLFLNLADDPAIERIITPRVALTVAEYLAFDLGMHVLAILTDMTNYAEALREISAAREEVPGRKGYPGYLYTDLANNYERAGRIKGKNGSVTQVPILSMPADDITHPIPDLTGYITEGQIVLGRDLFRKGIYPPVNVLSSLSRLMKDGVGEGKTRADHPEVGNQMYDLYSRAQEVRALAEIVGRAGLTGTDLKYLDAGDMFENHFLKQAADENRNLDETLARAWEVLSTLPEAELTKIKEKYIKAYYKGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MXI6</accession>
    <name>A0A075MXI6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Zinc-ribbon domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701752.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MXI6"/>
    <dbReference type="STRING" id="1459636.NTE_03298"/>
    <dbReference type="GeneID" id="41598952"/>
    <dbReference type="KEGG" id="nev:NTE_03298"/>
    <dbReference type="eggNOG" id="arCOG08024">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1536587_0_0_2"/>
    <dbReference type="OrthoDB" id="12019at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026870">
        <property type="entry name" value="Zinc_ribbon_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13240">
        <property type="entry name" value="Zn_Ribbon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zinc-ribbon" evidence="1">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="168" mass="17697" checksum="9171DCD09A95BF13" modified="2014-10-29" version="1">MSFGVDTLGGLSEKLKQLSNDTQNMYEAFIDATQLYKQGKMNEKEYFARIGDYLVATSAMNFLAIRVIFEIKGAMDKGTSVKNPTGGVATTAPPQQAGFGIGGFVNAGGSVGPSAGYTLPSPQAEPTFKPVDIELPRPKAGGSTKNCVFCGASIPQHAKFCSKCGKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MY35</accession>
    <name>A0A075MY35_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02134</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MY35"/>
    <dbReference type="KEGG" id="nev:NTE_02134"/>
    <dbReference type="HOGENOM" id="CLU_3322770_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="38" mass="4562" checksum="BB7E694D0C2F5F20" modified="2014-10-29" version="1">MWAASSDPPIMLFGIRRGHMYKKNIRLDYSMFLFELIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MY53</accession>
    <name>A0A075MY53_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oligoketide cyclase/lipid transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700820.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MY53"/>
    <dbReference type="STRING" id="1459636.NTE_02150"/>
    <dbReference type="GeneID" id="41597875"/>
    <dbReference type="KEGG" id="nev:NTE_02150"/>
    <dbReference type="eggNOG" id="arCOG05400">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131895_0_0_2"/>
    <dbReference type="OrthoDB" id="7914at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd07812">
        <property type="entry name" value="SRPBCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="139" mass="15347" checksum="BB7C408EDB99EB2A" modified="2014-10-29" version="1">MTTINASRKVQAPLDRVWEIIADVDSEPKYYPGLNSVRNISTNGNVIEREVTVGFRNSHGKQTVMLNPKRSVEVIMREGVMTGKRTVTLTPLDGGTATKIDISWDIEVPGVPVLFRGNVKNNIAKGTEEALERIARATQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MYD4</accession>
    <name>A0A075MYD4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MYD4"/>
    <dbReference type="KEGG" id="nev:NTE_02220"/>
    <dbReference type="HOGENOM" id="CLU_3362469_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="35" mass="4052" checksum="64522CF5FB8F79A3" modified="2014-10-29" version="1">MSATKEFGNNRNYILIGGDKKSSTLRNYYLERLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MYF9</accession>
    <name>A0A075MYF9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MYF9"/>
    <dbReference type="KEGG" id="nev:NTE_02250"/>
    <dbReference type="HOGENOM" id="CLU_2911320_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="61" mass="7206" checksum="C73DD34F0382D3E5" modified="2014-10-29" version="1">MVDRIEERIVDHLRRNARRISYKCNPIIKLTAEATQRMFKTAPCNINKLLVEIALRQKGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MYZ0</accession>
    <name>A0A075MYZ0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Fluoride-specific ion channel FluC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">fluC</name>
        <name evidence="8" type="synonym">crcB</name>
        <name evidence="9" type="ORF">NTE_02424</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>fluoride(in) = fluoride(out)</text>
            <dbReference type="Rhea" id="RHEA:76159"/>
            <dbReference type="ChEBI" id="CHEBI:17051"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:76160"/>
        </physiologicalReaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="8">Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cell membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 8">Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MYZ0"/>
    <dbReference type="STRING" id="1459636.NTE_02424"/>
    <dbReference type="KEGG" id="nev:NTE_02424"/>
    <dbReference type="eggNOG" id="arCOG04701">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114342_3_1_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062054">
        <property type="term" value="F:fluoride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140114">
        <property type="term" value="P:cellular detoxification of fluoride"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00454">
        <property type="entry name" value="FluC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003691">
        <property type="entry name" value="FluC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28259">
        <property type="entry name" value="FLUORIDE EXPORT PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28259:SF1">
        <property type="entry name" value="FLUORIDE EXPORT PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02537">
        <property type="entry name" value="CRCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0915">Sodium</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <note>structural</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF84474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="168" mass="17836" checksum="BD83289F883513EC" modified="2014-10-29" version="1">MPSGYGISLGAAGLNRPFPEVLIMPTRKYSRKNGGQKETERKKMKGIEFVLLAAGAVAGAFLRYRMAESPVMLDALPVNVLVINITGSFILGVFSILAAAWNLDSRYSLLVAIGFCGSLTTMSSFALETNNLLENRQLGLVALNIAANVGLSIGAIIGGRSIASVLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MZ23</accession>
    <name>A0A075MZ23_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ni,Fe-hydrogenase III large subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_02454</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MZ23"/>
    <dbReference type="STRING" id="1459636.NTE_02454"/>
    <dbReference type="KEGG" id="nev:NTE_02454"/>
    <dbReference type="eggNOG" id="arCOG01547">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG01551">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015134_3_1_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="entry name" value="Cytochrome-c3 Hydrogenase, chain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.80">
        <property type="entry name" value="NADH:ubiquinone oxidoreductase, 30kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052197">
        <property type="entry name" value="ComplexI_49kDa-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001135">
        <property type="entry name" value="NADH_Q_OxRdtase_suD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037232">
        <property type="entry name" value="NADH_quin_OxRdtase_su_C/D-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001268">
        <property type="entry name" value="NADH_UbQ_OxRdtase_30kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43485:SF1">
        <property type="entry name" value="FORMATE HYDROGENLYASE SUBUNIT 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43485">
        <property type="entry name" value="HYDROGENASE-4 COMPONENT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00329">
        <property type="entry name" value="Complex1_30kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00346">
        <property type="entry name" value="Complex1_49kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="HydB/Nqo4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143243">
        <property type="entry name" value="Nqo5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase 30kDa subunit" evidence="3">
        <location>
            <begin position="47"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="NADH-quinone oxidoreductase subunit D" evidence="4">
        <location>
            <begin position="320"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF84504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="567" mass="63870" checksum="FDAC04D8D4B62105" modified="2014-10-29" version="1">MDMMLGGDATDHSNTAKYKSAILQKLGKKVRGIHILNGNEIHVILSTKEEIPESCYYVHKDLKTKLATVICSDERLAGRGFMLRYVFAKENGEDVFIILTARIKENDDSAGGRHLTFPSIALHIPSAALYEREIKDMFGIWPDGNPDTRPLVLHEQWPEDVHPLRKDFDINSKIPRIYNREYPFTKVEGEGVCEIPVGPVHAGIIEPGHFRFSVLGENIINLETRLFYTHKGTEKLAESMNLDQVLLLSERISGDEAVANSMAYCQALERIARANVPKRALQIRTICAEMERIYNHLGTLAGMSTDVGFAYGASRLNILKERMMQLNEYVSGSRLLFGVNRIGGVGIDLMDDKLKHVVNTTNLLSEDFQRVISMLKDKSSVMDRMRNTGIITRRVAADLGLVGVAARCAGIDADTRRDHPYAEYDSLRLDMRHDTPQHLMEYEIEMQKMKGDALSRFEVRVEDVVNSISIVNEVITNLHSDNVLVVADVVDRLEPYSHALGYAESHRGQTIHWVMIGEDCNSLSRYKIRTASFVNWPAIEQAVLNDIVPDFPLVNKSLDLSYSGNDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MZ83</accession>
    <name>A0A075MZ83_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF4443 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NTE_02510</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226986977.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MZ83"/>
    <dbReference type="STRING" id="1459636.NTE_02510"/>
    <dbReference type="GeneID" id="41598214"/>
    <dbReference type="KEGG" id="nev:NTE_02510"/>
    <dbReference type="eggNOG" id="arCOG02103">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114386_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.30">
        <property type="entry name" value="GAD-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029349">
        <property type="entry name" value="DUF4443"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004115">
        <property type="entry name" value="GAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14544">
        <property type="entry name" value="DUF4443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55261">
        <property type="entry name" value="GAD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4443" evidence="5">
        <location>
            <begin position="115"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF84559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="223" mass="24203" checksum="D07138708C8CDA12" modified="2014-10-29" version="1">MFRQPKIVHTFVRALEKVASRYAPSRLLSFGEVHVFVALQLMSRRGHVSRNALSKELALGGGAVKTLVKHMKMNGLIETSNGGTKMTAKGKDIFEGLASAIPAEMDLPRSQVALAKYNYAVLLREFGFAVRSGIEQRDAAIKMGATGATTLLYHDGRFAMPDDGRQDPLKKEQALKKELAEMLKPQEGDVVIIGSAERGMKAAELAAKSAALTTIMAHEKHAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MZK2</accession>
    <name>A0A075MZK2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutamate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NTE_02631</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SR1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homohexamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 8">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701204.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MZK2"/>
    <dbReference type="STRING" id="1459636.NTE_02631"/>
    <dbReference type="GeneID" id="41598324"/>
    <dbReference type="KEGG" id="nev:NTE_02631"/>
    <dbReference type="eggNOG" id="arCOG01352">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025763_1_2_2"/>
    <dbReference type="OrthoDB" id="6425at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004352">
        <property type="term" value="F:glutamate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006538">
        <property type="term" value="P:L-glutamate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01076">
        <property type="entry name" value="NAD_bind_1_Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10860:FF:000003">
        <property type="entry name" value="Glutamate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006095">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006097">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033524">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014362">
        <property type="entry name" value="Glu_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033922">
        <property type="entry name" value="NAD_bind_Glu_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11606">
        <property type="entry name" value="GLUTAMATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11606:SF13">
        <property type="entry name" value="GLUTAMATE DEHYDROGENASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02812">
        <property type="entry name" value="ELFV_dehydrog_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000185">
        <property type="entry name" value="Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00082">
        <property type="entry name" value="GLFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00074">
        <property type="entry name" value="GLFV_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal" evidence="9">
        <location>
            <begin position="184"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="7">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIF84674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="417" mass="45452" checksum="0613DF1CE40255CA" modified="2014-10-29" version="1">MSQPINPFEMALKQLDEAAKLIKLDNGMHQVLAHPKRVLTVSIPVKMDSGEVKVFTGFRSQHNDARGPYKGGIRYHPQVSIDEVKALSMWMTWKCAVADIPYGGGKGGIICNPKEMSKGELERMTRRYAYSIADIIGPHTDIPAPDVYTGGNEMAWIMDTYSALKGNYVQPEVITGKPLSIGGSLGRNEATGRGLSFTVREAAKKLKINMKNATVAVQGFGNAGQFASQLVEEQGATVIAASDSKGGVYNKAGMSAQALRKHKEKTGSVVGFSGAKPISNEDLLETDCTILIPAALENQINGKNAKNIKAKIVAEAANGPTTPEADDVLFKNKTLVIPDILANGGGVTVSYFEWLQNLRREYWSEAEVNQKLDKNITKAFLDIYHTHEEYGVNMRKASMVLAVNRVVEAIKTRGLWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MZU6</accession>
    <name>A0A075MZU6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F420-dependent oxidoreductase, G6PDH family</fullName>
            <ecNumber evidence="3">1.1.98.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_02717</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.98.2" evidence="3"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701275.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MZU6"/>
    <dbReference type="STRING" id="1459636.NTE_02717"/>
    <dbReference type="GeneID" id="41598407"/>
    <dbReference type="KEGG" id="nev:NTE_02717"/>
    <dbReference type="eggNOG" id="arCOG02410">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027853_4_0_2"/>
    <dbReference type="OrthoDB" id="7684at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052749">
        <property type="term" value="F:glucose-6-phosphate dehydrogenase (coenzyme F420) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01097">
        <property type="entry name" value="Tetrahydromethanopterin_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="entry name" value="Luciferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050564">
        <property type="entry name" value="F420-G6PD/mer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019945">
        <property type="entry name" value="F420_G6P_DH-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03557">
        <property type="entry name" value="F420_G6P_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43244">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43244:SF1">
        <property type="entry name" value="5,10-METHYLENETETRAHYDROMETHANOPTERIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="Bacterial luciferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Luciferase-like" evidence="2">
        <location>
            <begin position="13"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF84759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="340" mass="37553" checksum="1089AB6AE575640E" modified="2014-10-29" version="1">MVRISFMVAHEQVNSRDLLKDVALMEENGLERCWSSDHYMPWWHTGAAGGATWPWLGAALARTDDIQVGTSVTAPILRYNPAIVAQVFATLDNMFPGRTFLTVGTGESLNEVPTGNQWPPYPERLGRLKEAMQVIKRLWSEDWVDFEGTYYTIKKSNLYTKPETKIPLYVAALGRQSAELAGAESDGLVTNEVNSTLIKERLLPAFEQGARQAGKDPDSMLKAVLMPASYDEDKQKALESMGYWKGAMIKAFFDVNYPDPRDIEENGQAVGNDTIEKMMPVISSAEEGIKKLQKYADLGFTDIILVNSSPDRSKLIELVAGQIAPALEGAAGERVTTAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N0U8</accession>
    <name>A0A075N0U8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Site-specific recombinase XerD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N0U8"/>
    <dbReference type="STRING" id="1459636.NTE_03065"/>
    <dbReference type="KEGG" id="nev:NTE_03065"/>
    <dbReference type="HOGENOM" id="CLU_856870_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="324" mass="37854" checksum="7B606FFA3D5D4F2D" modified="2014-10-29" version="1">MLQKTDPQVVDLDRDYIQEYLIDLRHRSPQTVDLYRRSLAACGLTTIRRDEIDQTWAKLRALLENRRVGKIFVNKAKTVVKGAIRRKTWKWEPTEDYQRIIELCGIEGEDVEEYSLDDIQTIFGVTFYEPDLFNACVLQSLSGIRAGALKGLGWTAFHKVPDVDGVLLYRVFSKGRHYTAAISERVFNFLKDRNRLNNPYLVWYDSGYKTPFTTLLRTRLYYQIVIKHGLGEVLELDRKSLQHSMRHFVLTEFAASLSENDASILSGHKVSSSTINLYVNKRIQRNGGMPLPDYHRKIAELYKKTPLYNFPIEDVEKWAQKWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLF2</accession>
    <name>A0A075MLF2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">D-glucuronyl C5-epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_00179</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLF2"/>
    <dbReference type="STRING" id="1459636.NTE_00179"/>
    <dbReference type="KEGG" id="nev:NTE_00179"/>
    <dbReference type="eggNOG" id="arCOG07790">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_901956_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010598">
        <property type="entry name" value="C5-epim_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06662">
        <property type="entry name" value="C5-epim_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="D-glucuronyl C5-epimerase C-terminal" evidence="2">
        <location>
            <begin position="122"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF82261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="308" mass="35111" checksum="260307879848F04D" modified="2014-10-29" version="1">MLPPTWKIFESITEKLSRRRGLLVIPLAIVVFTVSVPPTLMMKPIAFAEDSVVNVAVASDNNDNSSGKRTGWSDIEYINDVNNITMVDYKNLFGLNIGQVYNPNFVNDADWFLSHFEDHGDYYLVPYNYDWHFYSHISAPWYGCEAQSKAMLVTAKAYNETRDPKYLEFSKKVFNGFNSTILNQDGWLLGVAAENNNAAILNSQLFCVANLMTYYEYTGDEQALTLFKKGVDVLEKNIGNLTADCGTYYSLSKDRFVPHQQHPEYMKMLDRLYSMTGSDTLKNTLDKWQQDYLTCGKEDDGARQEQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLR4</accession>
    <name>A0A075MLR4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NTE_00354</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLR4"/>
    <dbReference type="STRING" id="1459636.NTE_00354"/>
    <dbReference type="KEGG" id="nev:NTE_00354"/>
    <dbReference type="eggNOG" id="arCOG01684">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117482_0_0_2"/>
    <dbReference type="OrthoDB" id="9623at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051081">
        <property type="entry name" value="HTH_MetalResp_TranReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33154">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR, ARSR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33154:SF33">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR SDPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12840">
        <property type="entry name" value="HTH_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="5">
        <location>
            <begin position="5"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF82436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="222" mass="25379" checksum="2FF14094D8EE7100" modified="2014-10-29" version="1">MDSDIILDILGNETRRKILATLSQEPMYFNQLAKELDIGQQAVLRHLQALEESGLVETYTEKSKLGAPDRKYYRLNNSFILTISLSEDDFTVTKQEIVESRHKESKKYYKVLDLMPEDAGEALASLQESLSDIEAEMSALESRLSDLRALKQLILSKLHKIGINSFEEDERKILYKIVTESPSSIAELSEMMDEKESRLKTTISAMRNKMNKDNAKTLLDLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLR9</accession>
    <name>A0A075MLR9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ORC1-type DNA replication protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NTE_00001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in regulation of DNA replication.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the CDC6/cdc18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699157.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLR9"/>
    <dbReference type="STRING" id="1459636.NTE_00001"/>
    <dbReference type="GeneID" id="41595955"/>
    <dbReference type="KEGG" id="nev:NTE_00001"/>
    <dbReference type="eggNOG" id="arCOG00467">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025112_3_1_2"/>
    <dbReference type="OrthoDB" id="195574at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08768">
        <property type="entry name" value="Cdc6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18139">
        <property type="entry name" value="HLD_clamp_RarA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01407">
        <property type="entry name" value="ORC1_type_DNA_replic_protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049945">
        <property type="entry name" value="AAA_22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015163">
        <property type="entry name" value="Cdc6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055237">
        <property type="entry name" value="Cdc6_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050311">
        <property type="entry name" value="ORC1/CDC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014277">
        <property type="entry name" value="Orc1/Cdc6_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02928">
        <property type="entry name" value="orc1/cdc6 family replication initiation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763:SF26">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13401">
        <property type="entry name" value="AAA_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22703">
        <property type="entry name" value="Cdc6_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09079">
        <property type="entry name" value="WHD_Cdc6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01074">
        <property type="entry name" value="Cdc6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="61"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc6 C-terminal" evidence="7">
        <location>
            <begin position="315"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="73"/>
            <end position="77"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF82085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="453" mass="50518" checksum="29F6A91E70E13BD3" modified="2014-10-29" version="1">MVSAQDIERMAAQAEQENSLFAAKGALDTFSSSSKTQAIGREAEAGQLVKALAGGQKQGYVSPFVFVYGRSGSGKSTVVQFVCEHLPRLLAFRLVNLRRVRTVYGCACLILEELGGDPKGGQTIDSIIERIAGGIEALAAAKFFVLVLDEFDVLLHDKRGRASDFVYKLLAVQQKLREEKGCMVCVIAISNNVMAAEEMDDRVRSRIGSCPEVFFDAYQKEEVVAILKDRAARAFVQPVGDEVIEYCAEKSSQEHGDARRAIDLLRMAAEIAGAEGGKNVSKLHIDMAEERLQKDRVERALSQASYHQKVAAGALVRITYLTQDAGESWYSTSTLYRQYCMSIRKTVRPLSYRRVAELFSELESAGLAVSRTGSKGRHGYGREYKLTLPPEVVGSKCLPDWWKILVEQKKKHEERMEKYKEEANKSDMPEPMRRCMRDAEKLDKESWAAFVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLW7</accession>
    <name>A0A075MLW7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_00414</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLW7"/>
    <dbReference type="STRING" id="1459636.NTE_00414"/>
    <dbReference type="KEGG" id="nev:NTE_00414"/>
    <dbReference type="eggNOG" id="arCOG00684">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1149773_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021027">
        <property type="entry name" value="Transposase_put_HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12323">
        <property type="entry name" value="HTH_OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase putative helix-turn-helix" evidence="2">
        <location>
            <begin position="2"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF82496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="241" mass="28407" checksum="60016CD4A5C1F858" modified="2014-10-29" version="1">MLNYKFRLYPTKEQELVLGHTLNGCRWVYNYFLSIPPMSEYDMNYALTELKEQHPWLRNYHSKMLQMVGKQVAAARKVTTGKLKYRRDYDYNAFTYNQTGFRLDNRGVLILSKVGRIKILLHRQPVNVKQVTVCRKYGKWYAIAACEILRSSYSNIIYKKPVGIDVGIAKFAHDSDNHVIENPQFLSRMLKPLRRAHRIKKADRQQQPRESQTHARQPVRAHKQQAQRLFAQNIDVLCQPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MM83</accession>
    <name>A0A075MM83_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Trypsin-like serine protease with C-terminal PDZ domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699540.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MM83"/>
    <dbReference type="STRING" id="1459636.NTE_00515"/>
    <dbReference type="GeneID" id="41596391"/>
    <dbReference type="KEGG" id="nev:NTE_00515"/>
    <dbReference type="eggNOG" id="arCOG02833">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031709_0_0_2"/>
    <dbReference type="OrthoDB" id="350578at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43019">
        <property type="entry name" value="SERINE ENDOPROTEASE DEGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13365">
        <property type="entry name" value="Trypsin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="472" mass="51154" checksum="C728535C9C3CC2F5" modified="2014-10-29" version="1">MIKAEFRGRVITETTAVTVFYLMASSSLLGIVMLSSLYLEHGRLQHVYAQQVALSENTAVELAKPAVVKIYNFASISLSVQAAGVKVQSLQGALDQLLSQGKLDIQDSRAVLDALIEVIYQDPGRYLAPLPDTLNLSASMNATGSGFIVTPDGYIVSNAHVVRFPDYDIEQTIRNDRDTFFATFLPQVFADTSGTLENIFVPMFPNVASLQLTPEEENGLLLAFIQYYHNAPYHITGFEPNVFAEMRVSIPGVLTGGKLVPAEVIPSATGKAEGKDVAVLKVEGNDNLPTVALGDENSLASLDDIIAIGFPGSVSIFPDLLAQGIQPSITRGQFSGFQPTIFGFSLVQTSTPISHGSSGGPAVDSSGRVVGITTSTSINPVTGQEENSAFNFLIPVSIVKDFLNRINVHAQESQFTKMYRQALLEFEAQNYSRSLEILEQLNRIAPGNPEVQNLISLVQTRMLLLENQEHQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMC7</accession>
    <name>A0A075MMC7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ferredoxin subunit of nitrite reductase and ring-hydroxylating dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NTE_00550</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the SsuE family. Isf subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699561.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMC7"/>
    <dbReference type="STRING" id="1459636.NTE_00550"/>
    <dbReference type="GeneID" id="41596418"/>
    <dbReference type="KEGG" id="nev:NTE_00550"/>
    <dbReference type="eggNOG" id="arCOG02578">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG02852">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062788_0_0_2"/>
    <dbReference type="OrthoDB" id="9353at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21496:SF23">
        <property type="entry name" value="3-PHENYLPROPIONATE_CINNAMIC ACID DIOXYGENASE FERREDOXIN SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21496">
        <property type="entry name" value="FERREDOXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="6">
        <location>
            <begin position="52"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF82631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="417" mass="46590" checksum="75F69FC3AD720715" modified="2014-10-29" version="1">MLDDENSNNNNFQYICRADQISQGQSRAFTITTNGDRGGGGGSSDRNSKIEIAVFNVDGAFFAISNVCVHKGGPLNEGALKGDIITCPWHGWKYSVRNGKSAHKGGDSISSYPVRVLEGRIYVSPIPKAVGKRISKPHKAYQELESAVKQHIRNVESSQVLPVDDDNATKVRVLGLSTTNMNDEVTPRKSTSESSLQFALDYAKRKYGAETVMLKLRQLNFRHCEGYYSKNAKACIFPCSISEMDEKDQMIEIYQRMIVWADVVIVATPIRWGSASSLYYQMVQRMNCVQNQIITHNNYLIRDKVSAFIITGGQDNVQHVAGELLSFWSQLGFVFGKFPFSGWSRGWYAEDTENNVSDNAKSLAFKQDIMRTVSGAVEMSRLIKKNRYDEKVITIDSKNNSNNNGATIRESVGSTHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMM0</accession>
    <name>A0A075MMM0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00303</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMM0"/>
    <dbReference type="KEGG" id="nev:NTE_00303"/>
    <dbReference type="HOGENOM" id="CLU_2565867_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="89" mass="9647" checksum="B9EFD99F39EB6887" modified="2014-10-29" version="1">MLAGDKCIVPTLTIAAVDLPSPIQVKTWLEDWEESAGGTWNEPNWSANPYRITVTGLTATQVQDAVESTLDAYNDQVGAGKKYLSYTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMV2</accession>
    <name>A0A075MMV2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00686</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMV2"/>
    <dbReference type="STRING" id="1459636.NTE_00686"/>
    <dbReference type="KEGG" id="nev:NTE_00686"/>
    <dbReference type="HOGENOM" id="CLU_3194327_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="45" mass="5150" checksum="C10A3621191DE2E7" modified="2014-10-29" version="1">MIKHIHRHMFNNISKLQSTGTQILGIVGMFVENIHLYTACVNIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MN14</accession>
    <name>A0A075MN14_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00803</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MN14"/>
    <dbReference type="KEGG" id="nev:NTE_00803"/>
    <dbReference type="HOGENOM" id="CLU_1830505_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="140" mass="15522" checksum="6B3DB4A8923D54AB" modified="2014-10-29" version="1">MSMRILAIIALIGGIGILFFLIPVIISAFNSSDQQILDRVNNMREVQVFQERFGPASPRISRDDGCCTTAVYYVVNGTLVSYPVYDTEKQYPSVRSMLLNINISPWETKMSLVCSGAGLRPTNLGADIQTIRTTDCLEKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MN18</accession>
    <name>A0A075MN18_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glyoxalase-like domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_00572</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MN18"/>
    <dbReference type="STRING" id="1459636.NTE_00572"/>
    <dbReference type="KEGG" id="nev:NTE_00572"/>
    <dbReference type="eggNOG" id="arCOG02708">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046006_18_2_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="5"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF82653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="181" mass="21006" checksum="A1675816CEAFB7BC" modified="2014-10-29" version="1">MRVYRISAITLKVDKMESSCQFYSKIPGFRIVYGGAPSDAFSTFEVGEGERKAYLNLELAERAGRKTVKLDNNKHHHHYTVVDQQQSLDHDENLEKAMKTTTGTEREKERGGKQGSRSDFGRIILHTENVDDLYEHMRKDEFLSNHAIFETEPVDAPWGERFFHIREPNGYQLSFAQPLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MN37</accession>
    <name>A0A075MN37_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">7-cyano-7-deazaguanine synthase</fullName>
            <ecNumber evidence="9">6.3.4.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NTE_00855</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>7-carboxy-7-carbaguanine + NH4(+) + 2 ATP = 7-cyano-7-carbaguanine + 2 AMP + 2 diphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:27982"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:45075"/>
            <dbReference type="ChEBI" id="CHEBI:61036"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; 7-cyano-7-deazaguanine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the QueC family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.20" evidence="9"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699801.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MN37"/>
    <dbReference type="STRING" id="1459636.NTE_00855"/>
    <dbReference type="GeneID" id="41596698"/>
    <dbReference type="KEGG" id="nev:NTE_00855"/>
    <dbReference type="eggNOG" id="arCOG00039">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081854_1_0_2"/>
    <dbReference type="OrthoDB" id="6532at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018317">
        <property type="entry name" value="QueC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42914">
        <property type="entry name" value="7-CYANO-7-DEAZAGUANINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42914:SF1">
        <property type="entry name" value="7-CYANO-7-DEAZAGUANINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06508">
        <property type="entry name" value="QueC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006293">
        <property type="entry name" value="ExsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIF82931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="219" mass="24823" checksum="6F5AAF6E9B3517E9" modified="2014-10-29" version="1">MDKALVMLSGGLDSATCLYWAIERFSVSAITFNYFGRLDKEKRATQLLAEKAGVQVIEVDVPFVKEASDFDGGGKMKKEKGSDLRWASYVPARNMMFYSIAAHYAEYLNAKWIVGGHNSHDASFFKDASRTYIEKMNSLFAESCLLCDGRPYQIVLPLAEMDRKAVIMLARKLHVPIEMTWSCHQEGELPCERCYACRQRLEAFSALGIRDPVLGKKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MN58</accession>
    <name>A0A075MN58_9ARCH</name>
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        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator, contains C-terminal CBS domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MN58"/>
    <dbReference type="STRING" id="1459636.NTE_00890"/>
    <dbReference type="KEGG" id="nev:NTE_00890"/>
    <dbReference type="eggNOG" id="arCOG00600">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1040582_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="1">
        <location>
            <begin position="91"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="1">
        <location>
            <begin position="145"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="267" mass="29575" checksum="D6D07E7523078C67" modified="2014-10-29" version="1">MQDISIKEVAPHIFQRPLLYVNPSDSVLQAATFLATGPQIYVDGLVMIEENKKKLVGRIGGYALVSHILKTRERWLDGEVSEIMEALERPLQENDPLGKALQVFRETKFAFMPVASNDRIVASLSLRDLIDHAKGLKVEVQKLASPLLTIDKDASVLDALSFMVEKGVRNLVFLEQDIHPYVINDRKFLAYLLRSQTRELVLRRGFEVLATMKLSGLGAIKGIRVDPKGAAGSMAHFFSDIGTSCLFADGMILTPWDLVIKGLGLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MN61</accession>
    <name>A0A075MN61_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PepSY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699268.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MN61"/>
    <dbReference type="GeneID" id="41596089"/>
    <dbReference type="KEGG" id="nev:NTE_00150"/>
    <dbReference type="HOGENOM" id="CLU_117489_0_0_2"/>
    <dbReference type="OrthoDB" id="12249at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="199" mass="20464" checksum="D880BBA80BC837C3" modified="2014-10-29" version="1">MEASGKSNRKTQMMVMAGVMAAVLATAAVFMTQPVLAQQGTNSTQSNNNQLQQQQQQGVPQLNGTVNLRDAAKAFLRDNVKVPFDSALNTAKGAVSNGTVIGGQLTVVQGYLVYAFKVANFDADTSQIVIVDAGNGSVLYTSGNMPLHFGGFGGGGYGCARGHFSGHHGMNWGDRAPWSSSPSSSDSGSSGGSSAALNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MN64</accession>
    <name>A0A075MN64_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00509</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MN64"/>
    <dbReference type="KEGG" id="nev:NTE_00509"/>
    <dbReference type="HOGENOM" id="CLU_805618_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="286"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="344" mass="38802" checksum="7C79E8CE1B6ABF36" modified="2014-10-29" version="1">MFDKWVGKLMEGGSRVYAGMSSKHESISEEEEKEEIEKFRTELAEMKLKVRTNPQEVEEWFDKANRFVHSTQDKQQESSTSTTSDAAPATEDNSNYTNNTNTAYKENNHISANVIDVIVDDNNNDDYYSETGGQAPQKQQIQEEQQNHRHQQEQELTELLEESAEIALDKISQLTITAKDRLSPIARSGISQLNVFKEEGNDLKKLLSSKEIIIYKTDAIAIMLRKYGGIIEFLDAYDKLIREGYVLDHSEPIESFFFEIPINGIKTRLGKLYYFHHRKYTAAAMPPFEPSPSSSSATAVTDGGRDDNSCKKYVAAVFLKGSTATTATSSTSNLARGRQEHQEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MN74</accession>
    <name>A0A075MN74_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MN74"/>
    <dbReference type="STRING" id="1459636.NTE_00165"/>
    <dbReference type="KEGG" id="nev:NTE_00165"/>
    <dbReference type="HOGENOM" id="CLU_2985480_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="57" mass="6480" checksum="756A9ED32F885BCA" modified="2014-10-29" version="1">MEMMMQITAMKSRGLNAVRVSSICTLPLLFFKLDEKTMDTRATQSDDVKSNRVARVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNA6</accession>
    <name>A0A075MNA6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ribonucleotide reductase N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699305.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNA6"/>
    <dbReference type="GeneID" id="41596129"/>
    <dbReference type="KEGG" id="nev:NTE_00205"/>
    <dbReference type="eggNOG" id="arCOG08805">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100103_0_0_2"/>
    <dbReference type="OrthoDB" id="9412at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="Ribbon-helix-helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="202" mass="23669" checksum="D6508261787BEBD1" modified="2014-10-29" version="1">MAGKKERLAGKSRPLLLRIPSNLLESLKIEAAKDDASVNSFITTVLKKYISWGRYQERLGFMPLHKSMVKTMLEKLTPEEIEEVGKMQKDQTIRDFLLFESGYNLKSFIQWIRLRCRVLGFDLRIKEEFEPDYTIFVMIHHDMGENWSLYYKGMFSAVLQELLPPDEKAYDQIIFETNRTSFAMHIVGLKVDDDMKEIMSVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNC7</accession>
    <name>A0A075MNC7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ferritin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_00638</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699633.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNC7"/>
    <dbReference type="STRING" id="1459636.NTE_00638"/>
    <dbReference type="GeneID" id="41596501"/>
    <dbReference type="KEGG" id="nev:NTE_00638"/>
    <dbReference type="eggNOG" id="arCOG01093">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104506_4_0_2"/>
    <dbReference type="OrthoDB" id="6978at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30295">
        <property type="entry name" value="BACTERIOFERRITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30295:SF1">
        <property type="entry name" value="DNA PROTECTION DURING STARVATION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0409">Iron storage</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin-like diiron" evidence="3">
        <location>
            <begin position="10"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF82718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="163" mass="18194" checksum="C7F890D5136079AF" modified="2014-10-29" version="1">MGRTEKKLLGKNAQVIVDILQKAYSDEMRIFHYFWYVGINMEGIGLVTYAQALKTQATGELMHAELLANRISELGGKAPSNPAEWEKLSTIGPLDPVKHLTLRSALERAMQFEGKAVENYNALAKKALELGDFVTYNLATTILADEVKDEQHTEDVLNSLEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNL7</accession>
    <name>A0A075MNL7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PEFG-CTERM sorting domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01078</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699970.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNL7"/>
    <dbReference type="STRING" id="1459636.NTE_01078"/>
    <dbReference type="GeneID" id="41596895"/>
    <dbReference type="KEGG" id="nev:NTE_01078"/>
    <dbReference type="HOGENOM" id="CLU_989073_0_0_2"/>
    <dbReference type="OrthoDB" id="11500at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="283" mass="30267" checksum="8A4AF71B46AE4B96" modified="2014-10-29" version="1">MKLLLAGMAVLLLSTLAAIPAYAQNSSSGSIHAYAVYVNGKSYIITYSITGGSVKSIQTCETGCITAMIQADSDGKLLVNLPGGLLNSISFDTKYYPVIFLDEIEVFADMTHTNCGITLEIPFQKGSKQIDMAGSFIPIGETISTQENSSNATVSRGRGFELGTVANADTCNFSFDQDRKKLHIEANGPANKEEKGFFQIALPHEFLGGPYTVLAEGKPAEFESVFSNATGKDTTTISLQYDGDKVHNIDIIGTTVIPEFGPAAIAAVASSMAMLVILRFRHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNR1</accession>
    <name>A0A075MNR1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNR1"/>
    <dbReference type="KEGG" id="nev:NTE_00365"/>
    <dbReference type="HOGENOM" id="CLU_2856918_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="64" mass="7839" checksum="288F011C6EC11752" modified="2014-10-29" version="1">MLKTKRFSSSDIFYILCKVWLKCQKKTTMRRIFYTLLQVSNSSFAIFFHKFHYFVCQQGKLFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNU9</accession>
    <name>A0A075MNU9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Lysine biosynthesis protein LysW</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00732</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699708.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNU9"/>
    <dbReference type="STRING" id="1459636.NTE_00732"/>
    <dbReference type="GeneID" id="41596584"/>
    <dbReference type="KEGG" id="nev:NTE_00732"/>
    <dbReference type="eggNOG" id="arCOG01588">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_195720_1_0_2"/>
    <dbReference type="OrthoDB" id="159847at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd13946">
        <property type="entry name" value="LysW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005906">
        <property type="entry name" value="LysW"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041070">
        <property type="entry name" value="carrier_LysW_Arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40393:SF2">
        <property type="entry name" value="ALPHA-AMINOADIPATE_GLUTAMATE CARRIER PROTEIN LYSW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40393">
        <property type="entry name" value="LYSINE BIOSYNTHESIS PROTEIN-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21344">
        <property type="entry name" value="Zn_ribbon_LysW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="57" mass="6025" checksum="7DF20508272A4ECF" modified="2014-10-29" version="1">MKKECQECGADINIPEDAVVGEIVTCPDCGGDFEIAAKAADKVELKPAETVGEDWGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MP40</accession>
    <name>A0A075MP40_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">eCIS core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_00486</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MP40"/>
    <dbReference type="STRING" id="1459636.NTE_00486"/>
    <dbReference type="KEGG" id="nev:NTE_00486"/>
    <dbReference type="eggNOG" id="arCOG10869">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_282389_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025295">
        <property type="entry name" value="eCIS_core_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13699">
        <property type="entry name" value="eCIS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eCIS core" evidence="2">
        <location>
            <begin position="121"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="871"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="879"/>
            <end position="896"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF82567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="1106" mass="116778" checksum="E4A5417A540305A0" modified="2014-10-29" version="1">MSSAFQSAGEKSSKASEISSISGVLSKSHELGHKNSADTGESFLSTHKKMVQRFSVNGFDFAKTGIFEPDLHGPGKSPENVQEDSSQKAIARTSDSILDSDTAKNAPPIVQGVLRSPGRSLDPHALEFFGSRLGHDFRNVRLHDDEAASYSASIFGAKAYTFGNHVVFNKGRNNQSTEGLQLFTHELAHVVQQDMGKGTGLQASTPQAEDEAREISALDQAESATVKVAAGTGMAFSLEDWQNSTPDVSTRSYTELIEDIDQISQWLDRQTTSSFESTHLEEVLVQLRGEVARRDAAARGRSPRRPRGRTRAAKSGTAAPANEAMQMPRVLAERSSFAYENSDEMRREVDLIMAWLQRSDVSRSDRQILQIELGNLAPQLHQDRIQRAMARRAETIQRALAPPADMQDARARTLESVRRIDGIARRPDGPGFVLMQGSEMIVLDESEVTRLRASVVEALDRAVTRARDMNEYTYSRGQAHLQLNYEEHPYVGFAVSVVSGEEPAELWNRVLDPIQNSNIAATGYRSMGDSVSLTSRAERALYAIEEADRARRLLNQGIERAESSAERIVTGLEITRDVAFTIALSLGAIAAAPVVAAGAAGAGLSGATAFGVTTVGTGAVVGLEGAGLGMVGGMAQEAAAGGSLSDVLASGGREARRWAKRGAVIGVSAGPTQAFRAVLGAGTPGLSTASNLVRSTAAEMGGNAIVGMGETALEGGSAKDILKSGGIGAASGLISGPLGAVTSRISSPTARTLAGMAVGGGTGYLGASIFSDDPNQAWQSAIIGATVSGVSSSHAGSAEMTPGQQRAYEIGRGVRRQARVMVGRARNVLAAAMIGTADAFPPARITGSLPSIIGRDDIALSLRNPALSEPVEAIPAARTGNSSAPDIETTPSSTQEAAPGQPASDVGPASPSQPARTTPGRVSGPEVFEELSRELGLTPPGASQRGAGSAAADALAGGLIGAQGAPGTVDIAFQSHGSATEVRNAYGVTGQQQQSAHVGPTSFLRDVPTYSRRRALTTLLDPATHRAFDDHWKNWAIRQRRAGRVNCTVGEMRQVMFDAIEQIPNMPQRTRNVLRWRMELELNELGLGLGDSIDLPYANISPTSTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MP87</accession>
    <name>A0A075MP87_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00947</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MP87"/>
    <dbReference type="STRING" id="1459636.NTE_00947"/>
    <dbReference type="KEGG" id="nev:NTE_00947"/>
    <dbReference type="eggNOG" id="arCOG08749">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1551873_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="175" mass="19849" checksum="E3189342420B704E" modified="2014-10-29" version="1">MIPCGILSSYISGATLEKSHDTVKADQPLTLSLSFKIDGAIREAFSQKNWEKAYNKHDNGFRMTIEVDIKSGRKTVMPLKFVRKAALFWTRNPKIPHRIWVSVVKDETPFYPLSEEEARLLLFDVNKVIELSGTELASGAHRLSADIRVYWGKHDYTEPVEISAKSNEVELRAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPC1</accession>
    <name>A0A075MPC1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane protease subunit, stomatin/prohibitin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_00561</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699571.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPC1"/>
    <dbReference type="STRING" id="1459636.NTE_00561"/>
    <dbReference type="GeneID" id="41596428"/>
    <dbReference type="KEGG" id="nev:NTE_00561"/>
    <dbReference type="eggNOG" id="arCOG01915">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047969_1_2_2"/>
    <dbReference type="OrthoDB" id="10752at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03401">
        <property type="entry name" value="SPFH_prohibitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000163">
        <property type="entry name" value="Prohibitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222">
        <property type="entry name" value="PROHIBITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222:SF0">
        <property type="entry name" value="PROHIBITIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00679">
        <property type="entry name" value="PROHIBITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Band 7" evidence="3">
        <location>
            <begin position="94"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF82642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="351" mass="39096" checksum="ABF77E559566E96B" modified="2014-10-29" version="1">MADDVFPSALVFSIILLIIAAVLSSIGIRRYMRRRRNRQREVRYEHPPPSQQQQQPSGLGIPSLKMPTLPRVENKLKIVAAVVTVIVVIIILAESVVIVQAGHRGVVLYLGAVEPRVLSEGIHFITPFAEQVIQMEVRTLKFQADASAASNDLQEVQTVIALNYHIDPNGVNTIFQQLGADYADRIISPTIQESVKASVAKFNAEELITKRETAKGVIADTIRKTLSQRDISVETVFITDFKFSEAFANQIEAKVVAYQKYLTEQNNLKAVQVVANQTVVQAEAQARANVAKANGESQAIKIINEQLKQSPDYLKWQSINKWNGQMPLALGTNAFPFFELPVQPQNQTRQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPE7</accession>
    <name>A0A075MPE7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_01358</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700199.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPE7"/>
    <dbReference type="GeneID" id="41597156"/>
    <dbReference type="KEGG" id="nev:NTE_01358"/>
    <dbReference type="HOGENOM" id="CLU_182704_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF83426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="92" mass="9685" checksum="E5E06DB2DDDAE561" modified="2014-10-29" version="1">MTDKIARDREEAKPSENKKWGAIAAVTAIMAALVLAAAPTFLQGASAEITSHCENRGGHEAPGQQENCQGQGQDESNQNPAGKEPPGQNKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPG6</accession>
    <name>A0A075MPG6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ATPase, Rnase L inhibitor (RLI) like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NTE_00607</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699608.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPG6"/>
    <dbReference type="STRING" id="1459636.NTE_00607"/>
    <dbReference type="GeneID" id="41596470"/>
    <dbReference type="KEGG" id="nev:NTE_00607"/>
    <dbReference type="eggNOG" id="arCOG00187">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017344_4_1_2"/>
    <dbReference type="OrthoDB" id="30658at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000152">
        <property type="entry name" value="ATP-binding cassette, sub-family E, member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001546">
        <property type="entry name" value="RNase L inhibitor homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013283">
        <property type="entry name" value="RLI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007209">
        <property type="entry name" value="RNaseL-inhib-like_metal-bd_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009945">
        <property type="entry name" value="PRK13409.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19248">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04068">
        <property type="entry name" value="Fer4_RLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01868">
        <property type="entry name" value="ABCEFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="50"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="74"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="346"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="573"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="573"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF82687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="605" mass="66983" checksum="5F7E012EE9C785B5" modified="2014-10-29" version="1">MGSDDPSSTHRVAVMDYELCQPRKCGLECIVYCPVNKTGGQCIIQREEDGKALISEELCTGCGICIKKCPFDAIVIVNLAKELSEDKIHQYGVNSFRFYRLPTPKKGAVVGLVGRNGMGKSTIVNILSGNMKPNLGKFEGGEPAWNEVLKYFQGTELKAHFEKIANGQLRASIKPQLVYLIPKAFKGTPKELLKKYDERNVSDSLVEELGLKNVLDRDIAALSGGELQRLAVAVAAAKDADYYFFDEPSSYNDVYQRLAVARVMKNLAEQGKSVMVVEHDMTLLDYLSDYVHIIYGEPGAYGIVSALQSTKVGINNFLEGYLPAENVRFREKAFRFDVATAMDDVVEEVTVASYTDVSKAFPSFKLNVAAGKIRRGEIVGMVGANALGKTTFMRMLAGVDKPDSGKIEVGAKISYKPQYLNQDYEGDVRSLLYTAYQSPIENSPAEEQIIIPLGIKKLLEKSVKNLSGGELQKVAVAASLLRQADIYALDEPSAFLDAEDRIAVAKFLQRFVRAQGRSAIIIDHDLQLIDLVSDTLVIFEGKPGIEGHATAPMRKEDGMNRFLQALAITYRRDETTGRPRVNKEGGRLDREQKDSGNYYYTRQPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPI7</accession>
    <name>A0A075MPI7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01406</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700234.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPI7"/>
    <dbReference type="STRING" id="1459636.NTE_01406"/>
    <dbReference type="GeneID" id="41597199"/>
    <dbReference type="KEGG" id="nev:NTE_01406"/>
    <dbReference type="HOGENOM" id="CLU_2079310_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="117" mass="13421" checksum="E4BD0E5C2AB47C16" modified="2014-10-29" version="1">MKDEVFVVREQLFKHNNNFYMLAGHPAGKHWDEHIHGATRYISRLDDFDDYSSTDLSQIDYQHRDLRDKIKRLRGTAVGEASGLGIEEKGHHVRLDDELADVGLFIAAISYLMYASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPR3</accession>
    <name>A0A075MPR3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, ArsR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700003.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPR3"/>
    <dbReference type="STRING" id="1459636.NTE_01120"/>
    <dbReference type="GeneID" id="41596934"/>
    <dbReference type="KEGG" id="nev:NTE_01120"/>
    <dbReference type="HOGENOM" id="CLU_125301_0_0_2"/>
    <dbReference type="OrthoDB" id="46231at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38600:SF2">
        <property type="entry name" value="SLL0088 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38600">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00419">
        <property type="entry name" value="HTH_CRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="180" mass="20618" checksum="2F0A6B289B7BCB43" modified="2014-10-29" version="1">MKAVQIIGDQVVARAMTDTMRRTILMMLRDRPMTQTQLAEELGLSKAALNHHLKILKQHNLVSIVKKEVESHGIVQKFFAANSYLQLYDFNSLPRDVVSYFYAARLERERGIISMLALNNQSLMRDQKLTSFITKNLSAYLIEAAGPYVNTEIDYGDEGIIYEIYTKAVKALLKEKLIEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQ54</accession>
    <name>A0A075MQ54_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987229.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQ54"/>
    <dbReference type="STRING" id="1459636.NTE_01630"/>
    <dbReference type="GeneID" id="41597406"/>
    <dbReference type="KEGG" id="nev:NTE_01630"/>
    <dbReference type="HOGENOM" id="CLU_1393620_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="189" mass="19957" checksum="C041796252555C48" modified="2014-10-29" version="1">MLENSALQTRRAFGVLFVAVSAAVGAGSVLSELAAINNMPVYWYAVIWIGSFGAVLAGAGPRFRKAIPAIRGRMKNSIKWSTGAKAINGVSWAGPFAAIGAFPHLYQYFILLGIGLGNLSTYILMKKYSGQNNPEQLLVGAISLVALPVALVIDGSLFATHQDIAVMVSRILIAIAYAVGGAYALLSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQC4</accession>
    <name>A0A075MQC4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01008</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385094.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQC4"/>
    <dbReference type="GeneID" id="43502586"/>
    <dbReference type="KEGG" id="nev:NTE_01008"/>
    <dbReference type="HOGENOM" id="CLU_3130668_0_0_2"/>
    <dbReference type="OrthoDB" id="373225at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="49" mass="5652" checksum="27C159B8CBFFDF3A" modified="2014-10-29" version="1">MTNSDDDLYVQLGLLGMNVEFFKQTRPSREQLSELLTKATELTRRYGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQC7</accession>
    <name>A0A075MQC7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">IPT/TIG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_01670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700449.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQC7"/>
    <dbReference type="GeneID" id="41597444"/>
    <dbReference type="KEGG" id="nev:NTE_01670"/>
    <dbReference type="HOGENOM" id="CLU_2021397_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00102">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IPT/TIG" evidence="2">
        <location>
            <begin position="50"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF83731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="133" mass="13638" checksum="258E7D7F9DC9C196" modified="2014-10-29" version="1">MKLDGRRIATLAAMVAVAFLSAIAIRGLVEPSNNNTAVTAQQQQQPMLKLEPTSGAPGGNVTITGNNFSMNSPVKVEFDGKMLNVGNITTTANGGFTVMANIPSDASDGGHEIKASDDKGKSASATFTVKKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQM8</accession>
    <name>A0A075MQM8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NTE_01099</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclic nucleotide phosphodiesterase class-III family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQM8"/>
    <dbReference type="STRING" id="1459636.NTE_01099"/>
    <dbReference type="KEGG" id="nev:NTE_01099"/>
    <dbReference type="eggNOG" id="arCOG01153">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063034_1_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07400">
        <property type="entry name" value="MPP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050884">
        <property type="entry name" value="CNP_phosphodiesterase-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42988:SF2">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE CBUA0032-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42988">
        <property type="entry name" value="PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="5">
        <location>
            <begin position="3"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF83172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="253" mass="29020" checksum="DB5CED705CCD6BD9" modified="2014-10-29" version="1">MQMRLVQLSDIHVGSLFSQQVFDTVIDEVNKLKPDAIIITGDLTDEGILPQFEKARSEIKRFECPNIIVIAGNHDYRHTGYLLFKKFFPTKHVYEFGDAVILTLGTARPDRDEGEVGYRQNLWMEKTLAKYADKVKIVAMHHHLVGIPDTGTDKILILDAGDTLRTCLQSKVNLVLCGHKHRPWVWKLGSLEIGYAGTTSSSRFRGFFENSYNIIEIENHKVNVDIKIVGKKRFPLSDLVEMYKPFLEEKHDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQU7</accession>
    <name>A0A075MQU7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01405</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQU7"/>
    <dbReference type="KEGG" id="nev:NTE_01405"/>
    <dbReference type="HOGENOM" id="CLU_2985486_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="57" mass="6748" checksum="8DF281623BD94137" modified="2014-10-29" version="1">MNVDIMISDWKKSYSMYVALTFKNEKILDVAQTMATWTFKRIIVNPVQIRKHKVKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MR30</accession>
    <name>A0A075MR30_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Probable translation initiation factor IF-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">infB</name>
        <name evidence="11" type="ORF">NTE_01200</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8 9">Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 9">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700065.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MR30"/>
    <dbReference type="STRING" id="1459636.NTE_01200"/>
    <dbReference type="GeneID" id="41597009"/>
    <dbReference type="KEGG" id="nev:NTE_01200"/>
    <dbReference type="eggNOG" id="arCOG01560">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002656_3_3_2"/>
    <dbReference type="OrthoDB" id="30957at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03703">
        <property type="entry name" value="aeIF5B_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16266">
        <property type="entry name" value="IF2_aeIF5B_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01887">
        <property type="entry name" value="IF2_eIF5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000112">
        <property type="entry name" value="Eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10050:FF:000001">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="entry name" value="Translation initiation factor IF- 2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00100_A">
        <property type="entry name" value="IF_2_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029459">
        <property type="entry name" value="EFTU-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004544">
        <property type="entry name" value="TF_aIF-2_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00491">
        <property type="entry name" value="aIF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003078">
        <property type="entry name" value="PRK04004.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381:SF4">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14578">
        <property type="entry name" value="GTP_EFTU_D4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="Initiation factor IF2/eIF5b, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 8 9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="3"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="77"/>
            <end position="81"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="131"/>
            <end position="134"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIF83272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="596" mass="65766" checksum="3E04F89E6691BA62" modified="2014-10-29" version="1">MELRQPVVVVLGHVDSGKTSLLDRIRGTAVQAREVGGITQHIGASFFPTDTIKEVTGPLYDRLAKSEAPIPGLLVIDTPGHEVFANLRMRGGSAADIAIVVADVNKGFEAQTIESIEILKKRKVPFVVALNKVDMVTGWRPFSKFISEEVKKQSADVQTMLDEKLYTVVGSLSRLGFPSEAFWRVKDFTKEIAIVPVSARTGVGIPELLAVLVGLTQQYMAKRLERHEGAARGIVLEINEEPGLGPSANIILLDGTLKQGDSIVVAKRDSAVQTRVKALLLPKPLDEMRDPRDKFKPVSEVIAAAGLKVTSPDLEGVLAGSPLYVFDKAKGEDELERLKSIVEGEIKNAIVSTETSGVILKCDTIGSLEAIIDLLKKDGVPIRTADIGSITRRDIIEASAVKESDRYHGVVLGFNVKVLDDAEREAQDRGVKIFNERIIYNLVRSYVDWVAYQKEHEESILFNEIPPICKFQFMKGFVFRRNDPAVFGAEIQVGKLRQKVHVINVEGKKVGIVHQIQDSGKAMEEATTGMQVAVSLKEPTIGRQINEGDIFYTDINSRQAKQLAERFSHRLNEQEKQVFDLILALKRKGDPAFGYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MR40</accession>
    <name>A0A075MR40_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700074.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MR40"/>
    <dbReference type="GeneID" id="41597019"/>
    <dbReference type="KEGG" id="nev:NTE_01210"/>
    <dbReference type="HOGENOM" id="CLU_1507319_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="178" mass="18451" checksum="2FFED54D8CB6D64C" modified="2014-10-29" version="1">MSSLSNLGSNDVVQLALGAVGGFAINQIANSQPVLNSPIIPLGNVVVSKADALTGGLGLAAAGTGYVLKQKTFVNLGAGAVVGTIISRMASGMGFNLQSHVNSAIAHARRLYDNTFPSGAYGINSAPVQNQNGLRKMSQVDLNAMNNGRMNSYMYGQPLKSELTRPNSAITAAMFSYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MR60</accession>
    <name>A0A075MR60_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01988</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700696.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MR60"/>
    <dbReference type="GeneID" id="41597735"/>
    <dbReference type="KEGG" id="nev:NTE_01988"/>
    <dbReference type="HOGENOM" id="CLU_198710_0_0_2"/>
    <dbReference type="OrthoDB" id="8303at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="75" mass="8390" checksum="F195ACF508121510" modified="2014-10-29" version="1">MSDTILNWESIIHKNARTSDRGDAGNVIEIEEDTITIERGPTAEYVIPKSKVEGFNGAEVALDVTLKELGQYRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MR97</accession>
    <name>A0A075MR97_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0284 protein NTE_01557</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01557</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0284 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987221.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MR97"/>
    <dbReference type="STRING" id="1459636.NTE_01557"/>
    <dbReference type="GeneID" id="41597339"/>
    <dbReference type="KEGG" id="nev:NTE_01557"/>
    <dbReference type="eggNOG" id="arCOG04272">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053134_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008939">
        <property type="term" value="F:nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02439">
        <property type="entry name" value="DMB-PRT_CobT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01086">
        <property type="entry name" value="UPF0284"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003200">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002805">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036087">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00303">
        <property type="entry name" value="nicotinate mononucleotide-dependent phosphoribosyltransferase CobT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003372">
        <property type="entry name" value="PRK04447.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38811">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38811:SF1">
        <property type="entry name" value="UPF0284 PROTEIN SLL1500"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02277">
        <property type="entry name" value="DBI_PRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52733">
        <property type="entry name" value="Nicotinate mononucleotide:5,6-dimethylbenzimidazole phosphoribosyltransferase (CobT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="365" mass="37535" checksum="CBEE0DF414867967" modified="2014-10-29" version="1">MVQDQDNIIGAKQAKTKFSAKNPFFCCVISHTATSEVPGLTVAGANPDLVKYTSPADAEFLHYGYCRCIPGVPATPDGKPTPAVITKAALELAEIPFLVVDAGTKVKPDIPCVSLGVKPGGNIAQENAMDVSDTKRALEYGHALGRQLARSSDLVVIGESIPGGTTTALAVLSALGVDAQFKVSSSMPENPHELKNKVVQSAFARARISTADGTPALEAVSLVGDPMMPTVAGITAGALEAGGAKVMLAGGTQMAAVLAVMKGLSIPLANLCMGTTVYVAKDSSADLAGLIKQVSPEVPVLACDLQLEKSSKPGLQAFARGFVKEGVGAGGSSIAAMLKTNASGKKMLAAIERVYERSIEKKSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRE0</accession>
    <name>A0A075MRE0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Large ribosomal subunit protein eL24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpl24e</name>
        <name evidence="5" type="ORF">NTE_01597</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the eukaryotic ribosomal protein eL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700391.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRE0"/>
    <dbReference type="STRING" id="1459636.NTE_01597"/>
    <dbReference type="GeneID" id="41597377"/>
    <dbReference type="KEGG" id="nev:NTE_01597"/>
    <dbReference type="eggNOG" id="arCOG01950">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_190191_0_0_2"/>
    <dbReference type="OrthoDB" id="55506at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00472">
        <property type="entry name" value="Ribosomal_L24e_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.20">
        <property type="entry name" value="Ribosomal protein L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00773">
        <property type="entry name" value="Ribosomal_eL24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038630">
        <property type="entry name" value="L24e/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055345">
        <property type="entry name" value="Ribosomal_eL24-rel_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000988">
        <property type="entry name" value="Ribosomal_eL24-rel_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011017">
        <property type="entry name" value="TRASH_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF034186">
        <property type="entry name" value="PRK14891.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01246">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00746">
        <property type="entry name" value="TRASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TRASH" evidence="4">
        <location>
            <begin position="20"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="3">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF83660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="80" mass="9203" checksum="80747B5AB9B1876D" modified="2014-10-29" version="1">MIRRRTSASDVISTRTFRNCSFCGSPIPAGTGLMHVRNDGRILWTCSDKCKKNLFVLRRDARKLKWTERYVKGGAQVKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRF7</accession>
    <name>A0A075MRF7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DNA polymerase IV</fullName>
            <shortName evidence="15">Pol IV</shortName>
            <ecNumber evidence="15">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">dbh</name>
        <name evidence="17" type="ORF">NTE_01677</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="15">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="15"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRF7"/>
    <dbReference type="STRING" id="1459636.NTE_01677"/>
    <dbReference type="KEGG" id="nev:NTE_01677"/>
    <dbReference type="eggNOG" id="arCOG04582">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012348_1_2_2"/>
    <dbReference type="OrthoDB" id="372207at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03586">
        <property type="entry name" value="PolY_Pol_IV_kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01113">
        <property type="entry name" value="DNApol_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050116">
        <property type="entry name" value="DNA_polymerase-Y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022880">
        <property type="entry name" value="DNApol_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053848">
        <property type="entry name" value="IMS_HHH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002677">
        <property type="entry name" value="PRK02406.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11076:SF33">
        <property type="entry name" value="DNA POLYMERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11076">
        <property type="entry name" value="DNA REPAIR POLYMERASE UMUC / TRANSFERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21999">
        <property type="entry name" value="IMS_HHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="Lesion bypass DNA polymerase (Y-family), little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 15" id="KW-0235">DNA replication</keyword>
    <keyword evidence="12 15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11 15" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="10 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 15" id="KW-0515">Mutator protein</keyword>
    <keyword evidence="6 15 17" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UmuC" evidence="16">
        <location>
            <begin position="17"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="active site" evidence="15">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Substrate discrimination" evidence="15">
        <location>
            <position position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AIF83738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="382" mass="42054" checksum="84A36685D2CE3FC4" modified="2014-10-29" version="1">MQACQYRPLPASLQRVVMHVDFDYFFAQCEEIRRPEIKERPVLVCVFSGRTEDSGVVSTANYVARKYGVKSGIPIRVAKAKLAQVDNALFLPLDADYYRQVSESAMAVIKEHADVFEHVGIDECFIDVSQRVKGSFDAAGALARTIKQQVQERIGLTCSVGVAPNKMLAKVASDYNKPDGLTAVGPENAVQFISALDVDKIPGIGPKTRDRLAELGVKTAGDLASFDLFKLMQEFGKKTATYIHNAAKGIDDEPVTESADGDRKQQIMRIVTLKKDAQSAEEMYADLEEICKQVYESATEKKAAFGSVGIILILDDLENVTRSRALKAHASSLDLLRATARSLLDEAMGEKKRSVRRLGVRISDLQDSSGQNTLFDYFSTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRH4</accession>
    <name>A0A075MRH4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exosome complex component Rrp42</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rrp42</name>
        <name evidence="7" type="ORF">NTE_01344</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RNase PH family. Rrp42 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700186.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRH4"/>
    <dbReference type="STRING" id="1459636.NTE_01344"/>
    <dbReference type="GeneID" id="41597142"/>
    <dbReference type="KEGG" id="nev:NTE_01344"/>
    <dbReference type="eggNOG" id="arCOG01574">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038194_0_0_2"/>
    <dbReference type="OrthoDB" id="30932at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11365">
        <property type="entry name" value="RNase_PH_archRRP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.70:FF:000017">
        <property type="entry name" value="Exosome complex component Rrp42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00622">
        <property type="entry name" value="Exosome_Rrp42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020869">
        <property type="entry name" value="Rrp42_archaea"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003282">
        <property type="entry name" value="PRK04282.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF8">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0271">Exosome</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="5">
        <location>
            <begin position="36"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="6">
        <location>
            <begin position="194"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF83412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="274" mass="29646" checksum="2A0A5B186AE8542A" modified="2014-10-29" version="1">MSTSKRSSIIVEHLRKQQMLDMMAKGKRIDGRAFDEQRPLEIETDVIKKANGSARVKLGNSEVIAGVKVETGEPFEGLENKGALIVSAEVLPTASPHVEPGPPDEEVIELARVVDRGVRESEMVDLEKLVLVEGKVVYTIFVDCSVLNADGNLFDATSYATVAAILTAKIPVLEMQEGKVVDTGKTIPMPVTTVPISITQVRIGDAILVDPTAEEEGAMDARITITTSDEGYCALQKGYTGSFTIEQIKKAGETARIKGEEVRAKIKEITNYGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRK4</accession>
    <name>A0A075MRK4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">3-oxoacyl-[acyl-carrier-protein] reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_01727</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRK4"/>
    <dbReference type="STRING" id="1459636.NTE_01727"/>
    <dbReference type="KEGG" id="nev:NTE_01727"/>
    <dbReference type="eggNOG" id="arCOG01259">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF133">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF83788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="258" mass="27508" checksum="F50ED770087DF9EE" modified="2014-10-29" version="1">MSAIYPLSLKGKIAAITGATRGIGLEMAKEFARRGATVLVCSRDIKSAGDAAKKVGKNAHPFSLDVSNPASVKAFVKDAIAEHGRIDILVNNAGYPFDKKMWYKEMHEVTDEEFDRVLEVDLKGTFRLTRAVLSVMVEKKNGGGVIISISSTPAVAGHVEGAPYTLAKAGIIAMTKHIALEYGNRGVRAYSLALGNIATDATFGSMDETARRQAAQENAMKRWGKPEEVARVAASLASDDFSFATGNTFVIDGGAVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRM6</accession>
    <name>A0A075MRM6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH-dependent glutamate synthase beta chain-like oxidoreductase</fullName>
            <ecNumber evidence="2">1.8.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01407</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.8.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700235.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRM6"/>
    <dbReference type="STRING" id="1459636.NTE_01407"/>
    <dbReference type="GeneID" id="41597200"/>
    <dbReference type="KEGG" id="nev:NTE_01407"/>
    <dbReference type="eggNOG" id="arCOG01292">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000422_3_3_2"/>
    <dbReference type="OrthoDB" id="27922at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="entry name" value="Alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028261">
        <property type="entry name" value="DPD_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42783">
        <property type="entry name" value="GLUTAMATE SYNTHASE [NADPH] SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42783:SF3">
        <property type="entry name" value="GLUTAMATE SYNTHASE [NADPH] SMALL CHAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14691">
        <property type="entry name" value="Fer4_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46548">
        <property type="entry name" value="alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="34"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="503" mass="54989" checksum="E61E4E9E0833BF41" modified="2014-10-29" version="1">MVEPNRVGAFPFRKADAGERKTNFSEVQQPYSEEEVMQEAERCLLCGTPVCIDACPVLLDVRGMNEAAARGDFKTAYERIRETNPLLGVTARCCPQLQGLCEDACVLKWSGQPIGIGLIQRYVADWERKHRRQQQQLPSPSVSIEPDTGKKVAVIGAGPAGLAGSELLRRYGHKVTVYEASAMPGGTAWYGVPDYHLPKDVLLDEIEKIKAMGVDIRTGVTVGKDATLAQLLDENDAVLITTGCKDARDLDTPGSDLKGVLSGYDFLESVFSDGVGNYLKNPKYDLGTEIIVIGGGDTSLDCARTALRLTKGRGNVTVLCRQPETELHTDPIMLEEAKEEGVKFRFLVQARSFEGDSNGHVTAALIDSLRAGAPGGQSGKQKLEPIPDKEFKMPCSTVLVAIGRGPNSFLQKKAGIEMGKRNAIAVGDDHKTSVERVFAAGDVTSGETLIVKAMEKGRDGAQRVHEYLMHMEANHMSFYEKYYKERSYDRMLAGKEDKVMPPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRN3</accession>
    <name>A0A075MRN3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative metal-dependent protease of the PAD1/JAB1 superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NTE_01664</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRN3"/>
    <dbReference type="STRING" id="1459636.NTE_01664"/>
    <dbReference type="KEGG" id="nev:NTE_01664"/>
    <dbReference type="eggNOG" id="arCOG01138">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116765_4_2_2"/>
    <dbReference type="OrthoDB" id="10589at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028090">
        <property type="entry name" value="JAB_dom_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051929">
        <property type="entry name" value="VirAsm_ModProt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34858">
        <property type="entry name" value="CYSO-CYSTEINE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34858:SF1">
        <property type="entry name" value="CYSO-CYSTEINE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14464">
        <property type="entry name" value="Prok-JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="JAB" evidence="6">
        <location>
            <begin position="2"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF83725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="113" mass="12789" checksum="53F65D94DE9D24EF" modified="2014-10-29" version="1">MPNESCAFLLGSGQGKISIAEILPVKNAHASYASFEIPPEELLKAYDYAERKEMQVAGIFHSHPSPPSPSRTDVRFMEINPVVWVIYSTTENRFAAWIFDEENVRQVDMTKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRU3</accession>
    <name>A0A075MRU3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Carbamoyl phosphate synthase arginine-specific large chain</fullName>
            <ecNumber evidence="14">6.3.4.16</ecNumber>
            <ecNumber evidence="3">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Carbamoyl phosphate synthase pyrimidine-specific large chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">NTE_02172</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Small subunit of the glutamine-dependent carbamoyl phosphate synthetase (CPSase). CPSase catalyzes the formation of carbamoyl phosphate from the ammonia moiety of glutamine, carbonate, and phosphate donated by ATP, constituting the first step of the biosynthetic pathway leading to pyrimidine nucleotides. The large subunit (synthetase) binds the substrates ammonia (free or transferred from glutamine from the small subunit), hydrogencarbonate and ATP and carries out an ATP-coupled ligase reaction, activating hydrogencarbonate by forming carboxy phosphate which reacts with ammonia to form carbamoyl phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>hydrogencarbonate + L-glutamine + 2 ATP + H2O = carbamoyl phosphate + L-glutamate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>hydrogencarbonate + NH4(+) + 2 ATP = carbamoyl phosphate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18029"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CarB family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.16" evidence="14"/>
    <dbReference type="EC" id="6.3.5.5" evidence="3"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRU3"/>
    <dbReference type="STRING" id="1459636.NTE_02172"/>
    <dbReference type="KEGG" id="nev:NTE_02172"/>
    <dbReference type="eggNOG" id="arCOG01594">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000513_1_3_2"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00171"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004087">
        <property type="term" value="F:carbamoyl-phosphate synthase (ammonia) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1030.10:FF:000002">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000026">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000002">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1030.10">
        <property type="entry name" value="Carbamoyl-phosphate synthetase, large subunit oligomerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="entry name" value="Methylglyoxal synthase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036897">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005483">
        <property type="entry name" value="CPSase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006275">
        <property type="entry name" value="CPSase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005480">
        <property type="entry name" value="CPSase_lsu_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058047">
        <property type="entry name" value="CPSase_preATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01369">
        <property type="entry name" value="CPSaseII_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003671">
        <property type="entry name" value="PRK05294.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009455">
        <property type="entry name" value="PRK12815.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF53">
        <property type="entry name" value="CARBAMOYL-PHOSPHATE SYNTHASE [AMMONIA], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405">
        <property type="entry name" value="CARBAMOYLTRANSFERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25596">
        <property type="entry name" value="CPSase_L_D1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02787">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00098">
        <property type="entry name" value="CPSASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01096">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48108">
        <property type="entry name" value="Carbamoyl phosphate synthetase, large subunit connection domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="Methylglyoxal synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="10 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 23" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ATP-grasp" evidence="21">
        <location>
            <begin position="70"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="21">
        <location>
            <begin position="624"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="domain" description="MGS-like" evidence="22">
        <location>
            <begin position="882"/>
            <end position="1029"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00060037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00069524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00074189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="AIF84226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="1029" mass="114150" checksum="5C2199A77F19584D" modified="2014-10-29" version="1">MYPVPINTQYVEQVIKEEKPDSIMLGFGGQTALNCGVALHERGILEKYGMRVLGTQIKGIEVTEDRQMFKDAMVKSDVPVLKSYAVNSIPDALKAAKELEYPVIIRVAYTLGGRGGGVAYNELELQEIAQRGLNLSMVHQVLIEKYVGHWKQVEYEVMRDYHGNSVIVCNMENVLAMRVHTGDNIVIAPSQTLNNYEYHMLRSAAIRATGYCGIVGECNIQFALDPTSEQYTAIEINARLSRSSALASKATGYPLAYMAAKIGLGYSLPELLNRITKVTTACFEPSLDYCVLKMPRWDFSKFELVKRKLGSAMKSVGEVMAIGRNFEEVLQKAIRMSATGKDGLVANGNDAQKEEDIERIEQSLLQPSDEIIYNVVRAMKAGMSIERIYQLSAIDPWFLKKIKNIVDMEEKLKKAGSFDGDMVRDAKKIGFSDKQIGRCLGTDEMQVRAMREKFDIKPVVKQIDTLAAEWPAKTNYLYLTYGGREDDVIVKDVKKSSNNSSSSSRMVVLGAGPYRIGSSVEFDWGTVNMVWGLKENGVKEISVINCNPETVSTDYDICDRLYFEELTLERVLDICDKEHPTGIVTCVGGQTANNLTPKLAKNGIKIVGTSSEDVDRAEDRAKFGQLLDTLGIKQPAWRQFTHLAEAKEFAETVGYPVLVRPSYVLSGAAMKVVWAEQQLERFLTDATNVNPEHPVVISKFLQDAAEVEVDAVADGKDVLIGAIIEHIDNAGVHSGDAMMSIPPWRLDRHIMETITDYSVKIGRALNVKGPLNIQYLVKDEQVLVIEANVRASRSMPFVSKFAGVNLINLAAKAMLGRPLPAKAKDLWLKAPGFGVKVPQFSFMQLEGSDIVLGVEMQSTGEVACFGNTFYDALSKAYMAAGYSLPLSGSVLITIGGQKNKEKLLPLISMLASMNYKILATEHTAEFMEHNNVKDVELVHKISEPNRKPNIADMLYERKLDFIINIPATSTLEKYVGMLQDEYLIRRKAVEMGVPVLTTVESASSFIKTLQWLRSNTPTLGPLGNYAKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MS21</accession>
    <name>A0A075MS21_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00117</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699240.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MS21"/>
    <dbReference type="STRING" id="1459636.NTE_00117"/>
    <dbReference type="GeneID" id="41596057"/>
    <dbReference type="KEGG" id="nev:NTE_00117"/>
    <dbReference type="HOGENOM" id="CLU_2406450_0_0_2"/>
    <dbReference type="OrthoDB" id="5944at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="83" mass="9457" checksum="73C2CC91C3FC42B0" modified="2014-10-29" version="1">MRKPVLLIDDAEDSLEAIRLFQESGQKYVEYHIKKFEESCCGELPTTRAPSVFAPEGIFKGLEGVRNYLSIEKQPDTGESAYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MS41</accession>
    <name>A0A075MS41_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01564</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700363.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MS41"/>
    <dbReference type="GeneID" id="41597346"/>
    <dbReference type="KEGG" id="nev:NTE_01564"/>
    <dbReference type="HOGENOM" id="CLU_2784241_0_0_2"/>
    <dbReference type="OrthoDB" id="5693at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="61" mass="6752" checksum="97DF0350011C730B" modified="2014-10-29" version="1">MSSRGNFTKGQTWGALKKAWRGYKIAKVQGDSGKMKEYATKIRTLQGELGVKQASFPELGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MS50</accession>
    <name>A0A075MS50_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01881</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700617.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MS50"/>
    <dbReference type="STRING" id="1459636.NTE_01881"/>
    <dbReference type="GeneID" id="41597638"/>
    <dbReference type="KEGG" id="nev:NTE_01881"/>
    <dbReference type="HOGENOM" id="CLU_881674_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="315" mass="35501" checksum="267FC92778EB0575" modified="2014-10-29" version="1">MNEELDKRKIKGVNVDEAEFHAKAEELWGKYELAIIPLRSPLDKSMSKSKRGLLPVDRDWQTRDYDPDPFVKGSRYAKGFYPNLAIATGSPGNHVLLSMDRRELPKLPLSEDLLTKLKKSSEILARGGGRLLKYKREEFPNGIPTIELGKTATLYGNGHYVPVLPSFTVEWDKYEAAYGRNKCGMMMPNFGVVEVSKAELLKVLQCFGETLPEEKESKKISHSYMEDHKENINKFIAACCTVGFGRRVQTTTFVDELNKWCAKNNLAPIDEDRVGNVLNPMGFKRRQARVNGGRARFYEGLSISLDVTSVTTGMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSC0</accession>
    <name>A0A075MSC0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3-phosphoshikimate 1-carboxyvinyltransferase</fullName>
            <ecNumber evidence="7">2.5.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">5-enolpyruvylshikimate-3-phosphate synthase</fullName>
            <shortName evidence="7">EPSP synthase</shortName>
            <shortName evidence="7">EPSPS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">aroA</name>
        <name evidence="9" type="ORF">NTE_01952</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21256"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="EC" id="2.5.1.19"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:21257"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EPSP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.19" evidence="7"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700667.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSC0"/>
    <dbReference type="STRING" id="1459636.NTE_01952"/>
    <dbReference type="GeneID" id="41597699"/>
    <dbReference type="KEGG" id="nev:NTE_01952"/>
    <dbReference type="eggNOG" id="arCOG04134">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024321_0_0_2"/>
    <dbReference type="OrthoDB" id="43788at2157"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00089"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003866">
        <property type="term" value="F:3-phosphoshikimate 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01556">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="entry name" value="Enolpyruvate transferase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00210">
        <property type="entry name" value="EPSP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006264">
        <property type="entry name" value="EPSP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01356">
        <property type="entry name" value="aroA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21090">
        <property type="entry name" value="AROM/DEHYDROQUINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21090:SF5">
        <property type="entry name" value="PENTAFUNCTIONAL AROM POLYPEPTIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000505">
        <property type="entry name" value="EPSPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="EPT/RTPC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Enolpyruvate transferase" evidence="8">
        <location>
            <begin position="9"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="22"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
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        <location>
            <position position="26"/>
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        <ligand>
            <name>3-phosphoshikimate</name>
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        </ligand>
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        <location>
            <position position="93"/>
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        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
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        <location>
            <position position="122"/>
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        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
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            <position position="168"/>
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            <name>3-phosphoshikimate</name>
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        </ligand>
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        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
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        </ligand>
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        <location>
            <position position="170"/>
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        <ligand>
            <name>3-phosphoshikimate</name>
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        </ligand>
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        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
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        <location>
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        <ligand>
            <name>3-phosphoshikimate</name>
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        <ligand>
            <name>3-phosphoshikimate</name>
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        </ligand>
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            <position position="345"/>
        </location>
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            <name>phosphoenolpyruvate</name>
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        </ligand>
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        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
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        <source>
            <dbReference type="ARBA" id="ARBA00004811"/>
        </source>
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        <source>
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        </source>
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        </source>
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        </source>
    </evidence>
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            <dbReference type="HAMAP-Rule" id="MF_00210"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AIF84010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="432" mass="46315" checksum="ED741E74A83C1189" modified="2014-10-29" version="1">MVKIQVRRSNVDGTVRCPSSKSYTHRALAIASLAADGGQSTITNALLARDTLATLACCKALGAEVQERRDIVQVKGRHDLPPPENVLNCENSGTTIRIMTAMSGLVKSGHVVLTGDESLRRRPMQPILDALGPLGVEAYSTKGNGTPPLIVRGGGIKGGTTVIDGSISSQFISGLLIAGIYADSEIVLKIKGDLVSKPYVRATMATMEQFGVKIDHEPNMLEYRIKQAEYKSTKFDVPSDFSTAALILSAGALAGKRLKVKGLNFNLPQGDSQIVEIMKQMDCVIKADKSKGEVVVQGAESLEGGEFNLADTPDLLPVVSILALKARSPVKITGVAHARVKETDRVANIARELVKFGAKVDEFHDGLTIVAPKKLKNASLEAYNDHRLFMAFTIASMMTERSIVEGAESVDVSYPNFVQDMKDLGAKLAPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSE3</accession>
    <name>A0A075MSE3_9ARCH</name>
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        <submittedName>
            <fullName evidence="3">Putative xylanase/chitin deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_00182</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0858">Xylan degradation</keyword>
    <feature type="domain" description="HYR" evidence="2">
        <location>
            <begin position="358"/>
            <end position="437"/>
        </location>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="557" mass="60052" checksum="632DF1465B2F507E" modified="2014-10-29" version="1">MTRKKISFKFMSTCSYPATHKAVAALMMTTVMVLLLITPASMALTASAQELTTAASVDTPSPKEACNCVIFRLDDVQDYWLVPVQAAIIDKFIEKNASLDMALIMNWVGNDPALVSKLREASLSQQNSSLIEMSLHGWNHVDYGKLSLGQQYDTLKAANARMQDLFGRKSAILVMPFNSYNEDTLKAMNQLGLRIISAEFDTEIESIYNPDEPDSPDNKIYRATTATATTIPKGQDANNSESGVGGDGSLDDDIKDQYGIYHLPQAVGFYTYDSEIPTKTPLALIEEKIGSTIASYGYAVVTLHPQDFTVKNADNSPTKDLSQKEIDDLGILIDWIKQNNHTIRTFSDATKVPLFPIVDNVAPSINAPMDKAVVSSSPLTHVDLGFPTLSDNVDPHPVAINNAPAVGFPRGTTKVIWTAADDAGNAANATQYVTVALVADKTRPTVTIDAPANTTAIKGSAPIANIPVKGTAFDDESGVKVIEVRTNDTDYKVAKQEGEGGGDGWSNWSASVTVKHPGITEIIARATDFFGNHQWRTIQVQVSLNGTAATTTGNGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSF0</accession>
    <name>A0A075MSF0_9ARCH</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01987</name>
    </gene>
    <organism evidence="1 2">
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        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
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            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
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    <dbReference type="STRING" id="1459636.NTE_01987"/>
    <dbReference type="GeneID" id="68225769"/>
    <dbReference type="KEGG" id="nev:NTE_01987"/>
    <dbReference type="eggNOG" id="arCOG05491">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2010198_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="129" mass="14528" checksum="AC48C768409E9739" modified="2014-10-29" version="1">MSEEPDRNVSQVAERVKSALSDLEKDGIMTKIGIDRDAGLVKVYTEKSDALKKASAGLAEILELAYTTAEHHPYWGMLYHAAEISKILLEKWDSDLSQDNTSEIGWRLDEIRMALERAGDMHPHHHQDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSI7</accession>
    <name>A0A075MSI7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Succinyl-CoA synthetase (ADP-forming) alpha subunit</fullName>
            <ecNumber evidence="6">6.2.1.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NTE_02033</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.2.1.5" evidence="6"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987265.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSI7"/>
    <dbReference type="STRING" id="1459636.NTE_02033"/>
    <dbReference type="GeneID" id="41597774"/>
    <dbReference type="KEGG" id="nev:NTE_02033"/>
    <dbReference type="eggNOG" id="arCOG01339">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052104_0_0_2"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009361">
        <property type="term" value="C:succinate-CoA ligase complex (ADP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004776">
        <property type="term" value="F:succinate-CoA ligase (GDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000006">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000277">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005810">
        <property type="entry name" value="CoA_lig_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004230">
        <property type="entry name" value="PRK05678.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117:SF2">
        <property type="entry name" value="SUCCINATE--COA LIGASE [ADP_GDP-FORMING] SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117">
        <property type="entry name" value="SUCCINYL-COA LIGASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001553">
        <property type="entry name" value="SucCS_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01798">
        <property type="entry name" value="SCOASYNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="CoA-binding" evidence="5">
        <location>
            <begin position="24"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="4">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001553-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF84090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="310" mass="32773" checksum="150BD620F122BB1C" modified="2014-10-29" version="1">MVMENNNSKFNIFDILVGQKGDKDYGKKPVVIQGITGSYGSTHTRLMKAYGTNVAAGVTPGKGGQTFEGIPIYNSMADAVKATGAQISGIFVPAQFFLGAATEALDAGVKLLVAIPEHVPVRDSIKVLEYAKSKGARMVGPNTPGVIVPEVMKVGIMPAQPFKAGNTVVFSRSGTLMYECSFNLTNKGFGQRLALGIGGDPINGTNLIEAFDLIRDRQDVDSVVVVGEIGGDAEEQLAEYIIKTSFSKPVVAYIAGRAAPKEKRMGHAGAIVYGNYGSADSKVSNYAKAGVPVAKRPGEVPELLAQKMRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSJ4</accession>
    <name>A0A075MSJ4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Roadblock/LAMTOR2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01701</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987236.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSJ4"/>
    <dbReference type="STRING" id="1459636.NTE_01701"/>
    <dbReference type="GeneID" id="41597471"/>
    <dbReference type="KEGG" id="nev:NTE_01701"/>
    <dbReference type="eggNOG" id="arCOG08684">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128582_1_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="127" mass="14560" checksum="42E3F54314E4E928" modified="2014-10-29" version="1">MPSTVDDFCQRILEIDRGIRFAGIASSSGRLIGFAYRKGLKPLLTKEESETAVLQSLMRMNMRATLEPKLGRTIYAYTLYGKVKRATIPIRESSRITHIFMISFDLGIKHEPIIRDRIIPRLDELFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSK6</accession>
    <name>A0A075MSK6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00247</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699335.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSK6"/>
    <dbReference type="STRING" id="1459636.NTE_00247"/>
    <dbReference type="GeneID" id="41596161"/>
    <dbReference type="KEGG" id="nev:NTE_00247"/>
    <dbReference type="HOGENOM" id="CLU_2949089_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="59" mass="6528" checksum="55758336CE91386F" modified="2014-10-29" version="1">MAVTEQINEEKLLADVSRYAKAYEASGEDPLSALTEALKLEMMKICQEELAKLDAEAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSM6</accession>
    <name>A0A075MSM6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02103</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700784.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSM6"/>
    <dbReference type="STRING" id="1459636.NTE_02103"/>
    <dbReference type="GeneID" id="41597835"/>
    <dbReference type="KEGG" id="nev:NTE_02103"/>
    <dbReference type="HOGENOM" id="CLU_2079311_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="117" mass="13346" checksum="84C36882E37AD079" modified="2014-10-29" version="1">MQFTPIVSAREVSTRLDPLQNQLQRIYDNQGIELYEESKGNVKIEDVRAATLMTCKADIINNIMILNLLASVKEGKIHEKTWRALIGLADDTIQLEFLERNLSQYLRLSLSLSLSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MST7</accession>
    <name>A0A075MST7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02154</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MST7"/>
    <dbReference type="KEGG" id="nev:NTE_02154"/>
    <dbReference type="HOGENOM" id="CLU_3353806_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="36" mass="3639" checksum="FD6C1768DED15915" modified="2014-10-29" version="1">MMTKKGKKAETITDSYSSFSAAPIPGYAAVGGGKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MST9</accession>
    <name>A0A075MST9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphate uptake regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02598</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701175.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MST9"/>
    <dbReference type="STRING" id="1459636.NTE_02598"/>
    <dbReference type="GeneID" id="41598291"/>
    <dbReference type="KEGG" id="nev:NTE_02598"/>
    <dbReference type="eggNOG" id="arCOG00318">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069302_1_0_2"/>
    <dbReference type="OrthoDB" id="40991at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:intracellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045936">
        <property type="term" value="P:negative regulation of phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="entry name" value="Phosphate transport system protein phou homolog 2, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028366">
        <property type="entry name" value="PhoU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026022">
        <property type="entry name" value="PhoU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42930:SF5">
        <property type="entry name" value="PHOSPHATE UPTAKE REGULATOR, PHOU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42930">
        <property type="entry name" value="PHOSPHATE-SPECIFIC TRANSPORT SYSTEM ACCESSORY PROTEIN PHOU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04014">
        <property type="entry name" value="MazE_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01895">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00966">
        <property type="entry name" value="SpoVT_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109755">
        <property type="entry name" value="PhoU-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="1">
        <location>
            <begin position="9"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="337" mass="37819" checksum="579A760A1CE68A79" modified="2014-10-29" version="1">MVRYARRLQQIGSSILISLPSQWVKDNNLKKGSIVPVEVNRDNTISIFPSSEEAESTKEVTIQYSPASMDSLVNQVYGAYLLGYDMIRVKAAGSITYDDAERFKRAMRKLVGLEIVEEDRQTISSQFLLDPNTLDAEKILRRMNSLVAGMFREMLEAIKERENIAKRSIGGRDDEVDRQYFLLVRLIRSAMMDQQLAGKLNLSNIDILDYRIAANLLESAGDFIVDLASMQDFTKLDLVDRFVQAGELVEKMQEKAVAAFAGKNRAESVEVVSTYGRFNEIINSIKEEASANADSKGSESTVAVLNLTYSMDRIARCWVDIADLVKPMHLIAPLKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSV7</accession>
    <name>A0A075MSV7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02186</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700851.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSV7"/>
    <dbReference type="STRING" id="1459636.NTE_02186"/>
    <dbReference type="GeneID" id="41597908"/>
    <dbReference type="KEGG" id="nev:NTE_02186"/>
    <dbReference type="eggNOG" id="arCOG00017">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_156337_0_0_2"/>
    <dbReference type="OrthoDB" id="42697at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40730:SF5">
        <property type="entry name" value="HTH CRO_C1-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40730">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR PROTEIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="22"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="134" mass="15085" checksum="0DA9337276B8F969" modified="2014-10-29" version="1">MLLPSEIEAKSLIPAVRAILAKKLIKEYSLKEEDVARVLGITQAAVSNYVRGTRGDIELISKLEGIREVMRMIDDIARELSTNKAYTPSTLAKFVGLTNYMRYSLLICDVHHSIESNIDETVCEQCRGTLIREQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSW0</accession>
    <name>A0A075MSW0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 14">DNA ligase</fullName>
            <ecNumber evidence="14">6.5.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Polydeoxyribonucleotide synthase [ATP]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">lig</name>
        <name evidence="18" type="ORF">NTE_02196</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 14 15">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="14"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700859.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSW0"/>
    <dbReference type="STRING" id="1459636.NTE_02196"/>
    <dbReference type="GeneID" id="41597918"/>
    <dbReference type="KEGG" id="nev:NTE_02196"/>
    <dbReference type="eggNOG" id="arCOG01347">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005138_6_0_2"/>
    <dbReference type="OrthoDB" id="31274at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07901">
        <property type="entry name" value="Adenylation_DNA_ligase_Arch_LigB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07969">
        <property type="entry name" value="OBF_DNA_ligase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3260.10:FF:000007">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000062">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.30:FF:000012">
        <property type="entry name" value="Probable DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00407">
        <property type="entry name" value="DNA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050191">
        <property type="entry name" value="ATP-dep_DNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022865">
        <property type="entry name" value="DNA_ligae_ATP-dep_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674:SF4">
        <property type="entry name" value="DNA LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674">
        <property type="entry name" value="DNA LIGASE 1/3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="ATP-dependent DNA ligase DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13 14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 14" id="KW-0132">Cell division</keyword>
    <keyword evidence="8 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11 14" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="12 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 14" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3 14 18" id="KW-0436">Ligase</keyword>
    <keyword evidence="10 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="17">
        <location>
            <begin position="329"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="585"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="active site" description="N6-AMP-lysine intermediate" evidence="14">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="420"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="426"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="AIF84250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="606" mass="68107" checksum="DCA8DFD6A7EEE1EB" modified="2014-10-29" version="1">MDFQPLVETFGKMEETSSRLALTDHLVALLKETPADLIDKVTYLIQGKLYPDYEGIEMGLAERMALRAIASSSSRSMSEVEAIYRKKGDIGDAAREAMESKGQSTLFSEQMTVERVYCTFDKIAKTTGPGSQETKLRLVASLLNDSTPDEGRYIMKFVMGALRLGIADYTVLDALAIAFTGDKANRKVLENAYNVSSDLGTVAKLLATKGLAAVKAVQITLFKPIRPMLAERVSTAEEAMERMDSRAAIEYKLDGERVQIHKGRDRVELFSRRLEKITDHYPDVSKAAMSLACKEAIMEGEVVAVNLQTGEYLPFQQLMHRRRKHGIEEAMENYPVVINLFDILYLDGKSRTELPYEERRKLLEKTVKGAKDNGIMLKIVPQVVATEPAEIDRFMASAIENGCEGVMVKMPSSTYRAGAREYLWVKLKREYRTELADTLDLVIVGALHGRGRRVGKYGALLLAAYDPKEDIFRSVTKVGTGFTDIHLDQFYRELEKHVIHQKHARVDTGMSMEVWFEPVIVIEVIASEITLSPSHMAAMDAIKEGYGLALRFPKFTGKIRDDKEPEGATTTDEIVTMYRRQLKIHSEAAKSKEQEKKKKESEEGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MT05</accession>
    <name>A0A075MT05_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01862</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MT05"/>
    <dbReference type="KEGG" id="nev:NTE_01862"/>
    <dbReference type="eggNOG" id="arCOG08812">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1536584_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="174" mass="19285" checksum="EE0563A86523B801" modified="2014-10-29" version="1">MNIIHYPADNSTVINLRLYDNRTNQDIPWVYYHLNITTADASSTPIVNDFFQTHNGTLVLKIVSDPSLSAAKIIASREPFIGAYVADPNSPIVIMTPFIKPSGSYLLHAEIFGVYYPTNIFDDRHIKGTTFAFDGSDVVNETHAVPEFSIIYLVMAASVAGVIALFRTKIKFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MT13</accession>
    <name>A0A075MT13_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cyclophilin TM1367-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MT13"/>
    <dbReference type="KEGG" id="nev:NTE_02194"/>
    <dbReference type="eggNOG" id="arCOG04488">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_160448_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025658">
        <property type="entry name" value="Cyclophilin_TM1367"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04126">
        <property type="entry name" value="Cyclophil_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclophilin TM1367-like" evidence="1">
        <location>
            <begin position="19"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="127" mass="13638" checksum="D9CB85FC012AA7B4" modified="2014-10-29" version="1">MQATGGSVSRVRLVAEVAGKGSAECELVRHLAPLTTSALLKGLPVQDRVHRLEDKFVYIETGLVIGAEKAKTQFKRGDLAFLPSNGAICFIIKDCTTQAMNAIGKIVNNMEIVEDVQTGDVIAVKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTE7</accession>
    <name>A0A075MTE7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700964.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTE7"/>
    <dbReference type="STRING" id="1459636.NTE_02330"/>
    <dbReference type="GeneID" id="41598046"/>
    <dbReference type="KEGG" id="nev:NTE_02330"/>
    <dbReference type="eggNOG" id="arCOG10136">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123156_0_0_2"/>
    <dbReference type="OrthoDB" id="6862at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009264">
        <property type="term" value="P:deoxyribonucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010708">
        <property type="entry name" value="5'(3')-deoxyribonucleotidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052419">
        <property type="entry name" value="5_3-deoxyribonucleotidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35134">
        <property type="entry name" value="NUCLEOTIDASE YQFW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35134:SF2">
        <property type="entry name" value="NUCLEOTIDASE YQFW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06941">
        <property type="entry name" value="NT5C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="18"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR610708-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="189" mass="21989" checksum="DA24FA968DB01022" modified="2014-10-29" version="1">MSGDNNTFSRAVKTVAIDVDSVLADVMLVWADEYNMRRNAKITKQDIIRWDIPTVLPITPEDVYKYFSHVWKSRWREIPPTEPGIGAVTKRIHRKGYRISIITKRERPTVAYVAKWLDMHKVFADDLLFIYDAVPKANYPFDVLIDDAPKNIIDVVKPKSAILFNQPWNRDFDWPIRVSSLSEAEEKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTI8</accession>
    <name>A0A075MTI8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02898</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701423.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTI8"/>
    <dbReference type="GeneID" id="41598577"/>
    <dbReference type="KEGG" id="nev:NTE_02898"/>
    <dbReference type="HOGENOM" id="CLU_2802408_0_0_2"/>
    <dbReference type="OrthoDB" id="374175at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="67" mass="7688" checksum="6693A59098BBADC7" modified="2014-10-29" version="1">MLSRETEKNNSNISDEELPSLSLFMDTRLPYNMENVVPTLLRIMVAKGMLSLNEAKRIMKSGESYLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTJ1</accession>
    <name>A0A075MTJ1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02903</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701427.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTJ1"/>
    <dbReference type="STRING" id="1459636.NTE_02903"/>
    <dbReference type="GeneID" id="41598581"/>
    <dbReference type="KEGG" id="nev:NTE_02903"/>
    <dbReference type="HOGENOM" id="CLU_1544250_0_0_2"/>
    <dbReference type="OrthoDB" id="8533at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="173" mass="20770" checksum="4CE0D6E3263BD61E" modified="2014-10-29" version="1">MPSQGYATIGLKPAILAKLQQITDEYYPGMFLPSALIILMNEIKRGYYTVDTCAIREDFGGRYTSLTIRSDVKAWLDENYEKYKEEYNRRYRANSFTQFASYFMLNMFESKAKSQNFIVKLKESDFRWLEEEYQKRKQEYRQKYSVFTFDQFADVFLRQLLDRVSEAKRMLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTJ2</accession>
    <name>A0A075MTJ2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S17e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NTE_02376</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701005.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTJ2"/>
    <dbReference type="STRING" id="1459636.NTE_02376"/>
    <dbReference type="GeneID" id="41598091"/>
    <dbReference type="KEGG" id="nev:NTE_02376"/>
    <dbReference type="eggNOG" id="arCOG01885">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_137726_1_0_2"/>
    <dbReference type="OrthoDB" id="52479at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.20">
        <property type="entry name" value="Ribosomal protein S17e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001210">
        <property type="entry name" value="Ribosomal_eS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036401">
        <property type="entry name" value="Ribosomal_eS17_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002242">
        <property type="entry name" value="PRK01151.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10732">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10732:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00833">
        <property type="entry name" value="Ribosomal_S17e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116820">
        <property type="entry name" value="Rps17e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="57"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="67"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF84428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="83" mass="9302" checksum="303AE5C580D0DAB5" modified="2014-10-29" version="1">MNRIKRISTELLQKYPDKFGLEFDANKKALSEVAVVKSKVLRNELAGYITSHLRKKAAQEKASSAMAEEEEAEEAGTEEESTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTP8</accession>
    <name>A0A075MTP8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02961</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTP8"/>
    <dbReference type="KEGG" id="nev:NTE_02961"/>
    <dbReference type="HOGENOM" id="CLU_2581217_0_0_2"/>
    <dbReference type="OrthoDB" id="375288at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="80" mass="9058" checksum="5D151ED32A9685B3" modified="2014-10-29" version="1">MEQDELIGGSSLRAGLSRSRDVLGDEVMQVIFRYLERSGFRFSSDTKYPVSRVSMAIRDVLGDYGTDIIMKNLIHEVDNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTU5</accession>
    <name>A0A075MTU5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02566</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTU5"/>
    <dbReference type="KEGG" id="nev:NTE_02566"/>
    <dbReference type="HOGENOM" id="CLU_2550074_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="82" mass="9113" checksum="DE74BCD53297DB7F" modified="2014-10-29" version="1">MIAALADRDYVVNCHSLVMFASELFAAGSAVESAIAYPKLLYKGAAIKMEFTPLSYGVKCLVGHHYPFTRHPYPAWDSILEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTV6</accession>
    <name>A0A075MTV6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02576</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701160.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTV6"/>
    <dbReference type="STRING" id="1459636.NTE_02576"/>
    <dbReference type="GeneID" id="41598271"/>
    <dbReference type="KEGG" id="nev:NTE_02576"/>
    <dbReference type="HOGENOM" id="CLU_477035_0_0_2"/>
    <dbReference type="OrthoDB" id="375703at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="571" mass="66681" checksum="C5ADA4B57F0BA815" modified="2014-10-29" version="1">MLAHELYLRNRSFKGEFVKSPKPVKKVIMRGMSPTLDKKTLQEYGEPLEEYKSFQVLFSMPSNTAPRLGLRFRTTSPNSPRPYVELYGQFQHIKAGPIISLEMGKGAASFIAELNLKTKKERIVAKNSIFLNIDKERYFISGKNLYDEYVRSRVITKDSKFSSTLFKRICQVFFKHVRSRWQEDRIQNKVVNFSLLVLPKDGEVEYRSTDEESDAGQSFTDSFGNKTKSFAKETTITAKFLSYDDPAFAINCSDGERFYRNLSIGTESHRLVNINTIDVFRIAGLQWMFTNTAKPSYHFNNTKNGIYYQLWRNYKDLDKESHRQEGRSNLKVLCYLTSQAKMEVMLDENLTMEDMKEIFARIEDGSHIPFHALEVLIETRGKTTIWTHYLSAVRSLLAKKKIDKHYLLSRFVLQLRENMFNWLDKKVREEPMQFFSKSDFCIKVLCKDVQRNEGKGYLMDDNEEYAHKVGVIAAEYIKFKENVEESSNSLRDILAYSRYDREKLRFVMQRIGLGLSLSKAPEDKIKKMESFIRSNQPSAEISDDSAYNDYSYFFYKGYFSKDVGMKKEAQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MU37</accession>
    <name>A0A075MU37_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Acetolactate synthase</fullName>
            <ecNumber evidence="10">2.2.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">NTE_02178</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2 pyruvate + H(+) = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="10">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="10"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700845.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MU37"/>
    <dbReference type="STRING" id="1459636.NTE_02178"/>
    <dbReference type="GeneID" id="41597902"/>
    <dbReference type="KEGG" id="nev:NTE_02178"/>
    <dbReference type="eggNOG" id="arCOG01998">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013748_3_1_2"/>
    <dbReference type="OrthoDB" id="6837at2157"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005948">
        <property type="term" value="C:acetolactate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044272">
        <property type="term" value="P:sulfur compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02015">
        <property type="entry name" value="TPP_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07035">
        <property type="entry name" value="TPP_PYR_POX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000008">
        <property type="entry name" value="Acetolactate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000007">
        <property type="entry name" value="Acetolactate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012846">
        <property type="entry name" value="Acetolactate_synth_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039368">
        <property type="entry name" value="AHAS_TPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00118">
        <property type="entry name" value="acolac_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968:SF13">
        <property type="entry name" value="ACETOLACTATE SYNTHASE CATALYTIC SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="THIAMINE PYROPHOSPHATE ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="5 10 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="13">
        <location>
            <begin position="4"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="11">
        <location>
            <begin position="194"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="12">
        <location>
            <begin position="390"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AIF84232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="562" mass="60551" checksum="90846083558D7C4D" modified="2014-10-29" version="1">MVEMTGAKALIHALEKEGVDVVFGLPGGANLPIYDALVGANLRHILVRHEQSAAHMADGYARIKRKSGVCFATSGPGATNIITGLATAHADSIPMVAVTGQVSLPMIGKDAFQETDIIGIANPCTKYSFQPRTPGEIPEVVKKSFYIAESGRPGPVLIDIPKDVQQQSADMRFPDLIKVRGYNPVIDADLSDIGKAVELILKAERPIILAGGGVILSGAFAELQALAELLMIPVVTTFKGKGAFPENHPLAMGPIGMHGHAEANKIIIEADCIIAVGSRFSDRSVGRFDEFGKGMSIIHMDIDPAEIGKNKSVDVAIVGDVKSSLRTLVKLLAKKVTKKDPENPWLRRKQELVQYFAESLKDYPREITAKKSLKKLRELLPAQSIVTTEVGQCQMWASLHFDVIAPGTFFSSTGLGTMGFGFPASIGAKAARPEVPVVDIAGDGSFNMTENSLAVSVIEKLPVIVFLMNNYMLGMVAQWQRTFYNRRYSGVHQHQCPDYVKVAEAYGAQGIRAQSMAELEKAIKTAIKSDVATVIDIPIDPDEDVYPFVAPGSSLKDMITGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MU71</accession>
    <name>A0A075MU71_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02667</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701232.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MU71"/>
    <dbReference type="STRING" id="1459636.NTE_02667"/>
    <dbReference type="GeneID" id="41598358"/>
    <dbReference type="KEGG" id="nev:NTE_02667"/>
    <dbReference type="HOGENOM" id="CLU_798335_0_0_2"/>
    <dbReference type="OrthoDB" id="8153at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="347" mass="37414" checksum="4575922CF760165B" modified="2014-10-29" version="1">MNPLRDDNGKIKTNVIVATVFAAMLVAMVPAVVAISSSMRAATEEAEAADMVQQPYVKAFAGSSALYEPNAGKTNVFGPGGIFPFFNDTFSCGNAITCGVQTDATFKGVFKENGTRGDNRFVATYTAPITYGDHQVKGHKYKVVMVDTKWNNDDPAQTPLPTRTPDFLLPGNGVAFDQYQHGHSMIDRADVPLFSNKVVVYGHANVYDETDGGKLVAKNIFMHLMVGKAVDEKGFYSDMQNNDGTPLVVLLFLVNVPSGVQLPGGIGPLTPEQAQSFTPLADDPSLKNPPPVDYAKLAEWGVNAPEPKPQSTPWSVDNPTQPVFFTFLLFTDAKAYNSANNNLPGVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUP9</accession>
    <name>A0A075MUP9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ParB-like partition protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_02897</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ParB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701422.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUP9"/>
    <dbReference type="GeneID" id="41598576"/>
    <dbReference type="KEGG" id="nev:NTE_02897"/>
    <dbReference type="eggNOG" id="arCOG11113">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023853_0_1_2"/>
    <dbReference type="OrthoDB" id="2340at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16396">
        <property type="entry name" value="Noc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2830:FF:000001">
        <property type="entry name" value="Chromosome partitioning protein ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2830">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1530.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050336">
        <property type="entry name" value="Chromosome_partition/occlusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041468">
        <property type="entry name" value="HTH_ParB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004437">
        <property type="entry name" value="ParB/RepB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00180">
        <property type="entry name" value="parB_part"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33375">
        <property type="entry name" value="CHROMOSOME-PARTITIONING PROTEIN PARB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33375:SF1">
        <property type="entry name" value="CHROMOSOME-PARTITIONING PROTEIN PARB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17762">
        <property type="entry name" value="HTH_ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109709">
        <property type="entry name" value="KorB DNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="ParB/Sulfiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB-like N-terminal" evidence="3">
        <location>
            <begin position="10"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF84935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="287" mass="33268" checksum="EAB6125BCC607035" modified="2014-10-29" version="1">MEFIDSSVVEQIEMKMIRPSQFAIRDTFQKDDPDFETLVNSIREHGLLQPILIRPLTAGFEIVAGHRRYHACKNLRWRFISAKIRELTDKQSYEIQLTENVQRKSMDPLEEAEAFRRYIVDFGWGGVTELAKKIGKSEEYVSHHMQLLRLPDEIKEKIANRSINVSQAIEIAQISSEKQSMIVEHIMNNDLTVRQIRELKNALNQESQDELVVAAKARAPVIARKTYLTLKIALNRIDNLINEVHSTVEPDQRAEIINFLMGIRLKIHSLIDDSIRFKNSSAKQHRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUQ4</accession>
    <name>A0A075MUQ4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Short-chain alcohol dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_02833</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701373.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUQ4"/>
    <dbReference type="STRING" id="1459636.NTE_02833"/>
    <dbReference type="GeneID" id="41598516"/>
    <dbReference type="KEGG" id="nev:NTE_02833"/>
    <dbReference type="eggNOG" id="arCOG01259">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_9_0_2"/>
    <dbReference type="OrthoDB" id="24596at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05324">
        <property type="entry name" value="carb_red_PTCR-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045313">
        <property type="entry name" value="CBR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43963">
        <property type="entry name" value="CARBONYL REDUCTASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43963:SF6">
        <property type="entry name" value="CHAIN DEHYDROGENASE FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G15350)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF84873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="252" mass="26884" checksum="A7D48B03DA2018FA" modified="2014-10-29" version="1">MSTTNQSKKVALVTGGNRGIGFAISKQLALQGISVIIGSRDIRQGEAAARSIAPPPAGGTTTTTTTTVSAFELDVTDQDSVDKLASTIHSRSGKLDILVNNAGVLLDETDNLPSKIDLQIVKATLETNLIGAWRLCQSFVPMMKKNKYGRIVNVSSGAGALTTIQQSLYAPAYSLSKSSLNVLTIMFANELRREDTNILVNAVDPGWVRTDMGGPSAPRSVEDGADTAAWLATLPDRGPTGGFFFDRKRIEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUS9</accession>
    <name>A0A075MUS9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Haloacid dehalogenase superfamily protein, subfamily IA, variant 3 with third motif having DD or ED</fullName>
            <ecNumber evidence="2">5.4.2.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.6" evidence="2"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701405.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUS9"/>
    <dbReference type="STRING" id="1459636.NTE_02875"/>
    <dbReference type="GeneID" id="41598555"/>
    <dbReference type="KEGG" id="nev:NTE_02875"/>
    <dbReference type="eggNOG" id="arCOG02293">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_13_3_2"/>
    <dbReference type="OrthoDB" id="31229at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008801">
        <property type="term" value="F:beta-phosphoglucomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050308">
        <property type="term" value="F:sugar-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07505">
        <property type="entry name" value="HAD_BPGM-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051806">
        <property type="entry name" value="HAD-like_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481">
        <property type="entry name" value="FRUCTOSE-1-PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481:SF4">
        <property type="entry name" value="GLYCEROL-1-PHOSPHATE PHOSPHOHYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="219" mass="24023" checksum="62FD55217AD5DD0A" modified="2014-10-29" version="1">MRGIIFDLDGVLVDSMPSHSQAWVQAFQNVANIQVEKRVIYVLEGMRGAELAEKILADHNSDASLAKKVIAEKDRLFKETKERPKAFEGVKEMIESLACAKAVVSGSNKHDVESVLDETIGKEKFDVIITADDIKRGKPDPLAFNTALSKLHVSAKDAAVVENAPLGVRAANNAGIQCYVALNNTLLLRSDFEGVIAKDRIFEKTSSLKGLLKEMCLRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MV30</accession>
    <name>A0A075MV30_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699966.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MV30"/>
    <dbReference type="STRING" id="1459636.NTE_01071"/>
    <dbReference type="GeneID" id="41596890"/>
    <dbReference type="KEGG" id="nev:NTE_01071"/>
    <dbReference type="eggNOG" id="arCOG02037">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1080101_0_0_2"/>
    <dbReference type="OrthoDB" id="30795at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051797">
        <property type="entry name" value="TrmB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002831">
        <property type="entry name" value="Tscrpt_reg_TrmB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34293">
        <property type="entry name" value="HTH-TYPE TRANSCRIPTIONAL REGULATOR TRMBL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34293:SF1">
        <property type="entry name" value="HTH-TYPE TRANSCRIPTIONAL REGULATOR TRMBL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01978">
        <property type="entry name" value="TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription regulator TrmB N-terminal" evidence="1">
        <location>
            <begin position="8"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="257" mass="29006" checksum="57EA03D8DD2DE096" modified="2014-10-29" version="1">MLEQQLVDLGLTQGEARVFLSLLKLGPSKVGAVVKDSKVSYSKVYDVLERLASKGLVSHATIGNIKHFNAVEPYRLHDYLQKKEDALKAQKATAEGLVSELAKVANRNRAAKGAEIFAGDRGLRTAYEILLKDASKNDVLRYFYPFDDYHPIATPFYSRLHLFQKEKEITQRGIGTVAFSRSAHYREIAGMVDMRFVPFPLPGTMDVFQDKLLMVSWESEIGILVTSKDIADHFARYFDSVWQVATISSGTRRRSRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MV79</accession>
    <name>A0A075MV79_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Methylmalonyl-CoA mutase family protein</fullName>
            <ecNumber evidence="7">5.4.99.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NTE_01111</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="5.4.99.2" evidence="7"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987189.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MV79"/>
    <dbReference type="STRING" id="1459636.NTE_01111"/>
    <dbReference type="GeneID" id="41596926"/>
    <dbReference type="KEGG" id="nev:NTE_01111"/>
    <dbReference type="eggNOG" id="arCOG01710">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128233_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004494">
        <property type="term" value="F:methylmalonyl-CoA mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02071">
        <property type="entry name" value="MM_CoA_mut_B12_BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.280">
        <property type="entry name" value="Cobalamin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006159">
        <property type="entry name" value="Acid_CoA_mut_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00640">
        <property type="entry name" value="acid_CoA_mut_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48101:SF1">
        <property type="entry name" value="METHYLMALONYL-COA MUTASE, LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48101">
        <property type="entry name" value="METHYLMALONYL-COA MUTASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="Cobalamin (vitamin B12)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="5" id="KW-0170">Cobalt</keyword>
    <keyword evidence="4 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="6">
        <location>
            <begin position="20"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF83184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="150" mass="15863" checksum="CA6561EF946C75E3" modified="2014-10-29" version="1">MSSSASSSTATTTMQQQQKPIRVLVSKLGLDGHDRGALVLCRAFRDAGMEVIYSGLFCTPEQVASMAVDEDVDVVAMSLLNGAHLTLFPKVARLLNEKGAGDILVVGGGIIPESDRKELESKGVTGNFGPGTPLSVIIKHINENVKKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVA7</accession>
    <name>A0A075MVA7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serine hydroxymethyltransferase</fullName>
            <shortName evidence="9">SHMT</shortName>
            <shortName evidence="9">Serine methylase</shortName>
            <ecNumber evidence="9">2.1.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">glyA</name>
        <name evidence="12" type="ORF">NTE_03553</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amino-acid biosynthesis; glycine biosynthesis; glycine from L-serine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SHMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.-" evidence="9"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701951.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVA7"/>
    <dbReference type="STRING" id="1459636.NTE_03553"/>
    <dbReference type="GeneID" id="41599170"/>
    <dbReference type="KEGG" id="nev:NTE_03553"/>
    <dbReference type="eggNOG" id="arCOG00070">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022477_2_1_2"/>
    <dbReference type="OrthoDB" id="5821at2157"/>
    <dbReference type="UniPathway" id="UPA00288">
        <property type="reaction ID" value="UER01023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000101">
        <property type="entry name" value="Serine hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000114">
        <property type="entry name" value="Serine hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049943">
        <property type="entry name" value="Ser_HO-MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000586">
        <property type="entry name" value="PRK00011.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680:SF35">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5 9" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="8 9 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Serine hydroxymethyltransferase-like" evidence="11">
        <location>
            <begin position="8"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="120"/>
            <end position="122"/>
        </location>
        <ligand>
            <name>(6S)-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>(6S)-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
        </ligand>
    </feature>
    <feature type="site" description="Plays an important role in substrate specificity" evidence="9">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9 10">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIF85581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="443" mass="48482" checksum="5DA8146F4A8B9800" modified="2014-10-29" version="1">MSARKAYSEVLSLMREHHKWFNRSIPLIASENIPSPAVREAIISDFGNRYAEGWPGERVYAGCVYIDQVEMICNELARKVFRAEFADCRATSGVVANLAIYAAFSSPGDWMMAASIPSGGHISHGKKEHAGTAGLVHGLNIEHYPFSKEEMTIDVDATKKKIEEMARDGRAPRMGMFGGSLFLFPHPVKELAGFMHDHGMYINYDGAHVAGLIAGGEFQDPLQEGADSMTMSSHKTLWGPQGGIIVSYEKHAEAIKKGIFPGNTSSHHLHHVAGKAIALAESLQFGKQYAKQVIKNAKALAEALAGYGFGVLGEKRGYTMSHQIAVDVTKFGDGGTIEKDLEKAGIILNRQLLPGDIKAGRHYMHPGGVRIGVPEVTRLGMKAGEMKDIAKFIKRVVVDKEDTKKVNKDVASFRKEFQKVQYAFDNAVGAYEYISLVSGGKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVH0</accession>
    <name>A0A075MVH0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, AsnC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700053.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVH0"/>
    <dbReference type="STRING" id="1459636.NTE_01187"/>
    <dbReference type="GeneID" id="41596997"/>
    <dbReference type="KEGG" id="nev:NTE_01187"/>
    <dbReference type="eggNOG" id="arCOG01117">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_170329_2_0_2"/>
    <dbReference type="OrthoDB" id="8136at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription regulator AsnC/Lrp ligand binding" evidence="1">
        <location>
            <begin position="6"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="83" mass="9465" checksum="2D0B378AD3E5A779" modified="2014-10-29" version="1">MPTAYVLINCDLGSEEDIIRDLKKLPEAVEVSGVYGVYDIIAKIRSDTMDKLRETITWHVRKIDKVRSTLTMIVIEGQGEKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVN8</accession>
    <name>A0A075MVN8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mut7-C RNAse domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03281</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385643.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVN8"/>
    <dbReference type="STRING" id="1459636.NTE_03281"/>
    <dbReference type="GeneID" id="41598935"/>
    <dbReference type="KEGG" id="nev:NTE_03281"/>
    <dbReference type="eggNOG" id="arCOG04290">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112469_1_0_2"/>
    <dbReference type="OrthoDB" id="1266at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002782">
        <property type="entry name" value="Mut7-C_RNAse_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39081">
        <property type="entry name" value="MUT7-C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39081:SF1">
        <property type="entry name" value="MUT7-C RNASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01927">
        <property type="entry name" value="Mut7-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mut7-C RNAse" evidence="1">
        <location>
            <begin position="10"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="169" mass="18694" checksum="30BB7C89A158D94B" modified="2014-10-29" version="1">MSEKEEDDIKFLADAMLGSVARKLRIFGFDTLYVPDTSDNEILRLAAEQGRVILTADKELFKRMMKQGAPGVLVDGTSDLDDMAHIFEKLGISANLFSRIGSRCTSCNGALVQKRPEEVGALVPATVLARHDGFWQCTDCQKVYWDGGHLGRIRAFARNLEDRLSASKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVY1</accession>
    <name>A0A075MVY1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative esterase of the alpha-beta hydrolase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_02740</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701296.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVY1"/>
    <dbReference type="STRING" id="1459636.NTE_02740"/>
    <dbReference type="GeneID" id="41598430"/>
    <dbReference type="KEGG" id="nev:NTE_02740"/>
    <dbReference type="eggNOG" id="arCOG09020">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042894_1_0_2"/>
    <dbReference type="OrthoDB" id="9032at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07209">
        <property type="entry name" value="Pat_hypo_Ecoli_Z1214_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021095">
        <property type="entry name" value="DUF3734"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF57">
        <property type="entry name" value="BLR7027 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12536">
        <property type="entry name" value="DUF3734"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="4">
        <location>
            <begin position="16"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF84782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="360" mass="40995" checksum="18D568FE3341AF02" modified="2014-10-29" version="1">MKSEEGIHKIQFETVLVMQGGGSLGAYECGVYKVLERHGIKFDIVAGTSIGAINAGIIAGSKSGQPAKDLEDFWLHIAEYVTPVTLSDKARSVAAWMYSATYGNAKMFAPAWPFMPNSTHLYDLEPLKSTLKNYIDFEKLASDNKNNSIPRLVVTATDIKKSESVVFDSHSERLSADHLIACAGYPFYGISWTKVDGRYLWDGSMMSNTPLREVIDVSPRNDKRVYIVNLFPKYAERLPESMMDSLHRARDIMYTDRTDHNIKMSKAVKRYLELLRDMYEFISDMPLDDAKKEKFLEIEKKYHRVARERGAIIENVVKIERKEDIPFIFEDADFSIATIRKLIRKGEQDAEQALKKARPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MW02</accession>
    <name>A0A075MW02_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="15">KH-domain/beta-lactamase-domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">NTE_01415</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">SR1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987211.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MW02"/>
    <dbReference type="STRING" id="1459636.NTE_01415"/>
    <dbReference type="GeneID" id="41597209"/>
    <dbReference type="KEGG" id="nev:NTE_01415"/>
    <dbReference type="eggNOG" id="arCOG00543">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009673_5_1_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22532">
        <property type="entry name" value="KH-II_CPSF_arch_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16295">
        <property type="entry name" value="TTHA0252-CPSF-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019975">
        <property type="entry name" value="aCPSF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050698">
        <property type="entry name" value="MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033769">
        <property type="entry name" value="TffA_KH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03675">
        <property type="entry name" value="arCOG00543"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203:SF51">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17214">
        <property type="entry name" value="KH_TffA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0806">Transcription termination</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="13">
        <location>
            <begin position="183"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-Casp" evidence="14">
        <location>
            <begin position="408"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AIF83479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="613" mass="67588" checksum="C68B24153E69B477" modified="2014-10-29" version="1">MAVILQSLPQEAALTKIEYEGPKIALYSRNPAYLMQNSQVVSNMVNTIKKRIVVRTDESIRKPQAQSAEIISKSIPAEVGVAGTFFDPVLGEAVVFAKKPWMLAQTGEDFDNIDLAEKTGWRVRIRKAPRSMAAIENMYRLMGETVAERTRFYREVGDKIFRDKLIGEAEASLMTLGGFAEVGRSCMLLATQESKILLDCGINESARDSLSALPRFDIAGIGMDEIDAVVLSHAHMDHAGFVPALFKYGYDGPVYCTEPTMLLMEILQQDYVKRSKNPLYLERDIERALVHTIPLTHGIVTDISPDVKLVLSNSGHMLGSVSAHLHIGNGDHNLVYTGDMKFGKTLALDNAYWNFPRVETMIIESTYGGKEDILCPREEAEANLARMITSAAHAGGRVLIPVPAAGIAQELLLTLDLLSKASKITNVPVLVEKIISDATAIYEAYPEFLSRDLRPRISESEESPFGSQFSTVESFETKQGEPAVILAPSSMLTGGPAAGYLKQIASDPTSKVIMVSYQAPDTPGRLLLDGSRQITVEGEALSVRCQIDRIDGFASHSDYNQLMAYVSRLRPKLRRVLVNHGERPKAQNLASQINKIFKIQTQHPLVQEAIKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MW56</accession>
    <name>A0A075MW56_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_02822</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701364.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MW56"/>
    <dbReference type="GeneID" id="41598507"/>
    <dbReference type="KEGG" id="nev:NTE_02822"/>
    <dbReference type="HOGENOM" id="CLU_851570_0_0_2"/>
    <dbReference type="OrthoDB" id="11292at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF84862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="303" mass="32044" checksum="9AD6ED2CE9E2031C" modified="2014-10-29" version="1">MNSVSAILLLGLLSFGAIISSSAKPAFAHTFSGDESATFLAKVEGLKVEINQIGKNISNSSLVKWHVDKIGEFWNANDTKEVAERNQRVANDVTTGLDKLFSEVNKTNPDPAVVNQTASGLQDTLGEVVSVRIDSSALQNATVNALALRSVLDETLEDYGIATGVSEEEEEEGGNSTSAANQAAEATTGPAKIVNMAAYQTAQGLAASATGMFDKLKTMSSSNATSAIGEIDKGLKDLQKAIADKAPLDDAKKIVDGTINPNLQAAYRLQVVPEFPVPLLMSVGAIAAVVVITRYYRHFRRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MW83</accession>
    <name>A0A075MW83_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SPFH domain, Band 7 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_03482</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987062.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MW83"/>
    <dbReference type="STRING" id="1459636.NTE_03482"/>
    <dbReference type="GeneID" id="41599111"/>
    <dbReference type="KEGG" id="nev:NTE_03482"/>
    <dbReference type="eggNOG" id="arCOG01915">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047969_1_2_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03401">
        <property type="entry name" value="SPFH_prohibitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000163">
        <property type="entry name" value="Prohibitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222">
        <property type="entry name" value="PROHIBITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222:SF0">
        <property type="entry name" value="PROHIBITIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00679">
        <property type="entry name" value="PROHIBITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Band 7" evidence="4">
        <location>
            <begin position="89"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="250"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF85510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="365" mass="40204" checksum="E071316C098582DA" modified="2014-10-29" version="1">MVEAGTIVAIAIIVIVFGIGGFFAFRRIQRARLLKGRYGGSRTRRTTPDGEPLEDPRSYTAGSSAFRRLPKMIILVVIGLVVLTTMLASSIKLVEAGNRGVLLQFGAVDTNVSLPEGLHIVTPFRDNVLQMDVRTQKTSEVAASASKDLQDVRTEVALNYHLNPDSAQIVYQQLGFGYAERVISPAIQESVKQVTARFNAEELITKRETVKTEIEEQIKQRLAKYNIIVEIISITEFKFSEQFTKAVESKVEAEQRALQASNELRRIQIEAQQAEAKAIGEQKANIAHAEGVRQSNVLQAEGEAQAIQIIDQRLRESPSYLEWLKTQRWDGKLPFVVGGGDGGATPFIQIPTGGEGAGQNATRTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MW89</accession>
    <name>A0A075MW89_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative DHD superfamily phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02874</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701404.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MW89"/>
    <dbReference type="STRING" id="1459636.NTE_02874"/>
    <dbReference type="GeneID" id="41598554"/>
    <dbReference type="KEGG" id="nev:NTE_02874"/>
    <dbReference type="eggNOG" id="arCOG00423">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076809_0_0_2"/>
    <dbReference type="OrthoDB" id="18016at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052968">
        <property type="entry name" value="Nucleotide_metab_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42146">
        <property type="entry name" value="3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42146:SF1">
        <property type="entry name" value="OLIGORIBONUCLEASE NRNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="DHH phosphoesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDH" evidence="1">
        <location>
            <begin position="2"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="319" mass="35625" checksum="D46FD35A6AE67FD9" modified="2014-10-29" version="1">MKVFIFSHESDLDGLYSAAIGLMRYPQAATVFLGYGVENMQKMGNFLYSATHFSKERGLVIVADLGLNDDAIETCRQIFADASRNGWKLMWVDHHPWSQAAIDAVKEYAELVHDPSGAKCAADLMYERLVPENDLAKKLASMAHTMDFFTKDQYLTPITELIRYYQNFPDFYERLSALAKKSAKGILWDTDMHEDYARYSKLRDEAKVQALSTLQVRPIDGIKVAYVQSSPYLNSSLFSEEVFAATGADLAMFYSAKGKVSIRRNNDRISCRQVASYLPEGGGHDYAAGATFKSDPSDISAIVGELEAAVAKAVKRENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWB7</accession>
    <name>A0A075MWB7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701841.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWB7"/>
    <dbReference type="STRING" id="1459636.NTE_03400"/>
    <dbReference type="GeneID" id="41599046"/>
    <dbReference type="KEGG" id="nev:NTE_03400"/>
    <dbReference type="eggNOG" id="arCOG10335">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_775237_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="357" mass="39160" checksum="BCFB1846FF46A072" modified="2014-10-29" version="1">MAFKVERKPLDSARDTLDIANNLNKPGLKIELPQDKWLKKIWIILKGQVDTSGASTLNEDNPMSLIKNVRLVVNGKAVRTVDFPMLYYLNIFDYHGVVPTRFKTPTTALTNQLFKAVACIDFATNPQAPNGDFSAIDAMLPAQDLSSLSLEVDTGAASDLGTNLTFDNASLYTVLEQVSMDKATEENLYGKNREKLWFILQSMAEKKIDGAYTNYQFSQDLPVGNVLRRSLIKAVDNGIRSDSIVSGFRTRVPVAFMEDVWNWESAQEDDRVGLRLGKLTGTNEIETSSGTAIIPSIRGLVLNDYADLGFINATSLKKGSVVWEANTGSPTGTSKVVMLHEELASAQAALNALSTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWB9</accession>
    <name>A0A075MWB9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Membrane-bound serine protease (ClpP class)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NTE_03517</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWB9"/>
    <dbReference type="STRING" id="1459636.NTE_03517"/>
    <dbReference type="KEGG" id="nev:NTE_03517"/>
    <dbReference type="eggNOG" id="arCOG01910">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024619_1_1_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07020">
        <property type="entry name" value="Clp_protease_NfeD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052165">
        <property type="entry name" value="Membrane_assoc_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002810">
        <property type="entry name" value="NfeD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056738">
        <property type="entry name" value="NfeD1b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056739">
        <property type="entry name" value="NfeD_membrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33507">
        <property type="entry name" value="INNER MEMBRANE PROTEIN YBBJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33507:SF4">
        <property type="entry name" value="NODULATION COMPETITIVENESS PROTEIN NFED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01957">
        <property type="entry name" value="NfeD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25145">
        <property type="entry name" value="NfeD1b_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24961">
        <property type="entry name" value="NfeD_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141322">
        <property type="entry name" value="NfeD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="370"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="403"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="NfeD1b N-terminal" evidence="8">
        <location>
            <begin position="116"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="NfeD integral membrane" evidence="7">
        <location>
            <begin position="302"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="NfeD-like C-terminal" evidence="6">
        <location>
            <begin position="441"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF85545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="512" mass="55039" checksum="56E7F4E7CACD1105" modified="2014-10-29" version="1">MNLKNNVKKPSYSLHQTVRELLLLRKQFHRLLMLIVLCAAGEFVVYCCSISLSPGISSPITIVHAQEATSSSSSPRERQILWVDVKDIISSATADHISSAISRASDSREEVDDKSSSSNFSAVIIALDTPGGSVDATFKIIESIQSSKVPVIGYVYPQGKSAWSAGTIILLATDYAAMAPFTTIGSAQPVAGGIPVNDTKIVNAITEKIVTLAQLHNRNVTQATRFVTHNDNLTPEAAMKNHVIEAIARDPEELLQKANNSTVMTLAGPKLLDTPFSNSHIVVHEPSLRVSLVDILSNPLLSTTLFTIGFFALIYGLTSPGFGSEIAGAAMIILALIGQGFDINWAAFALLAIGAGLIAYELYSPGFGAMGIGGIVLLVVGSTLMITQPVRPLLISEHRMSELVLISATITAPLGVFFALITYKAWRAKTQAPLPFVLQSQTGVTVEAISSTKPGFVIVGGEYWRARTEEGSGIEIGKGQNVRVVRKDSDLLIIEPFKEEKEEKEKREGKDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWJ5</accession>
    <name>A0A075MWJ5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Restriction endonuclease S subunit</fullName>
            <ecNumber evidence="5">3.1.21.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_02987</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-I restriction system S methylase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.3" evidence="5"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWJ5"/>
    <dbReference type="STRING" id="1459636.NTE_02987"/>
    <dbReference type="REBASE" id="90012">
        <property type="entry name" value="S.NevSR1ORF2988P"/>
    </dbReference>
    <dbReference type="KEGG" id="nev:NTE_02987"/>
    <dbReference type="eggNOG" id="arCOG02626">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021095_0_2_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009035">
        <property type="term" value="F:type I site-specific deoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17273">
        <property type="entry name" value="RMtype1_S_EcoJA69PI-TRD1-CR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.220.20">
        <property type="entry name" value="DNA methylase specificity domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000055">
        <property type="entry name" value="Restrct_endonuc_typeI_TRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044946">
        <property type="entry name" value="Restrct_endonuc_typeI_TRD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052021">
        <property type="entry name" value="Type-I_RS_S_subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30408:SF12">
        <property type="entry name" value="TYPE I RESTRICTION ENZYME MJAVIII SPECIFICITY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30408">
        <property type="entry name" value="TYPE-1 RESTRICTION ENZYME ECOKI SPECIFICITY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01420">
        <property type="entry name" value="Methylase_S"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116734">
        <property type="entry name" value="DNA methylase specificity domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0680">Restriction system</keyword>
    <feature type="domain" description="Type I restriction modification DNA specificity" evidence="4">
        <location>
            <begin position="18"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Type I restriction modification DNA specificity" evidence="4">
        <location>
            <begin position="216"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF85022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="418" mass="46916" checksum="29B68A748568A106" modified="2014-10-29" version="1">MHTMNGPNSKPTEIGDLPEHWKVVRLEEVAEIVGGATPLTSVTEYWNGDIPFVTPTDITKLDGHSTIRNTAKRITKKGLKAISAKLIPSGSVLMTSRATIGFCAINEVPVVTNQGFATLICRDTIDNLYALHLLRSLKPQIEQLANGTTFKEVSRTSLRKLLIPLPPLPEQIVIASVLEKACRLQAKRRLINTRCSHLVDSIFFKMFGDLFSNSLGWKRVLIQDVCIQITDIIHKMPKAVDEGIPFISVMNLTKGDYIDFSDVKFISKDDHVRLIQRCRPQQGDVLYTRIGVNYGIARLVETNTEFSISYSLALLKPDRQLIHPIFLKNILNTQFVKLQADRKTRGIGVPDLGIKEIKSLEIMLPPLKLQEEFAALATKVTSIQRKQIDEYQKIDQLSKSLTMMFFSGKKMSASNSQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWV4</accession>
    <name>A0A075MWV4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Roadblock/LAMTOR2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01683</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700460.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWV4"/>
    <dbReference type="STRING" id="1459636.NTE_01683"/>
    <dbReference type="GeneID" id="41597456"/>
    <dbReference type="KEGG" id="nev:NTE_01683"/>
    <dbReference type="eggNOG" id="arCOG08684">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128582_0_0_2"/>
    <dbReference type="OrthoDB" id="9222at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046600">
        <property type="entry name" value="DUF6659"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20364">
        <property type="entry name" value="DUF6659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="124" mass="13603" checksum="5E9F76803B59DA53" modified="2014-10-29" version="1">MQRNLCERVIKLDKNIRFAGIVNANGEVIEGGFQQGIQPLLNGPAEQQMYIQSLSNVVTLKQYADMLGDFRYSITEHDKVTLLTFPLGDGILCVSASPKADSAKIRNKVAALLKGNKPRGSKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MX45</accession>
    <name>A0A075MX45_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01798</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700554.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MX45"/>
    <dbReference type="STRING" id="1459636.NTE_01798"/>
    <dbReference type="GeneID" id="41597563"/>
    <dbReference type="KEGG" id="nev:NTE_01798"/>
    <dbReference type="HOGENOM" id="CLU_2056129_0_0_2"/>
    <dbReference type="OrthoDB" id="381520at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="120" mass="13729" checksum="4DC7835A1396ACBA" modified="2014-10-29" version="1">MSESEKERRKLSGAGEAWTAVLDAERAFTNPIEKEVYTLSELDDNEIRFAVQALTVGSAFKTDLMRELVTNLAVLKRSKKRQGERAVISLVRNSTAKIMQTVQQSRFKRVMSNREDYEND</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MXA3</accession>
    <name>A0A075MXA3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03223</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MXA3"/>
    <dbReference type="STRING" id="1459636.NTE_03223"/>
    <dbReference type="KEGG" id="nev:NTE_03223"/>
    <dbReference type="HOGENOM" id="CLU_923175_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="301" mass="34023" checksum="4FB7048C4A50F25B" modified="2014-10-29" version="1">MCRRLLLSNIQSPSAIVATLDALGYRSITDEIVAEIVSDAVYSVFNKLGEHITALVIRNLCKINNRTEQQLFRRCDLVEGSIRAMFGRAADFFIDEIKDELVPFSLAKKPGLSLEEIANEMREVEVMRFVGNLAGHEHVGFIYNRKATKDAVLSQFFDHLAAPRTQALISLSSCGAEGKSAAGKFEKVQSIITYDEFLKVKEKSEAMDVMFKWIWDIHKSNQSGRETRIAGEDASWFLRNGFENEFLDAERMMGRRLHDKMSVLCSYDAEGITLASQLKRVIESHRYVIIEQPMAVYVAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MXC7</accession>
    <name>A0A075MXC7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03243</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MXC7"/>
    <dbReference type="STRING" id="1459636.NTE_03243"/>
    <dbReference type="KEGG" id="nev:NTE_03243"/>
    <dbReference type="eggNOG" id="ENOG502N5BY">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1381448_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="211" mass="22698" checksum="7B51629F6A92C4C8" modified="2014-10-29" version="1">MFIQQHYYYHLALAGASLASSLLLSPLLASAVSDYFTLENAKVQVDESTVDARLETSGIIPQDGQSAYGYGILTGAGNEGIIVSTTHAGVLDSELQRDASDPVWHNHFVKLDKNVSGRCGDNLEVVDITMESPGEIQVRESRVVLDDIPFLLEGTSAMTKDPLTLAPGASPQQIVSFAMDLKFDGGTLKAVCITNITPAEDADIEREQEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MXH1</accession>
    <name>A0A075MXH1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative RNA-binding protein, snRNP like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03283</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701740.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MXH1"/>
    <dbReference type="STRING" id="1459636.NTE_03283"/>
    <dbReference type="GeneID" id="41598937"/>
    <dbReference type="KEGG" id="nev:NTE_03283"/>
    <dbReference type="eggNOG" id="arCOG01695">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003612_2_1_2"/>
    <dbReference type="OrthoDB" id="10943at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.310.10">
        <property type="entry name" value="ibrinogen binding protein from staphylococcus aureus domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008532">
        <property type="entry name" value="NFACT_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051608">
        <property type="entry name" value="RQC_Subunit_NEMF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041120">
        <property type="entry name" value="RqcH_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15239">
        <property type="entry name" value="NUCLEAR EXPORT MEDIATOR FACTOR NEMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15239:SF6">
        <property type="entry name" value="RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT NEMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05670">
        <property type="entry name" value="NFACT-R_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05833">
        <property type="entry name" value="NFACT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NFACT RNA-binding" evidence="1">
        <location>
            <begin position="436"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="657" mass="72306" checksum="EFB50F943E4E37A5" modified="2014-10-29" version="1">MELSGVELRYLVNEIGARVTSGHYISAVNAVTKDSLLLRLHHPTQEDIMLVLSARGIWITKLKFKPVEDNSLERAAIAELERARVESLEQAGSERIATLRLRRLDGQARVVVCEFFGDGNIIICDEKMQMLAILRPIEVRHRTLKVGLRYAFPPQRGVDVFALSLEQMLALRNEAKNLDVLRWIGRGLSMPKKFVEEVAKRAGIEPSRQAGQLADEEVGRIFSTIKSLVDDISAGRNHEPVVIMQGEKPVDALPIVTQEAQKLEVKKAPTYMEALDEVLSNEILDIGRSSRTIEIDRQIAVLEHDLAEQNKAKEEVLQKAAAIRKLAGELMAVSYSNPADDAIKGVLAANSASLVTEKGVKYVQVAGENIEAQQNLAKLSSMLFARAKEMERGNASIEEARSKLLAQIERLRGQTAAIHKKMVVQKQAAKEWYERYRWFVTSDGLLAIGGRDASSNSALVRKHLTEDDIVFHAEVHGSPFFIVKNAAAPAREGKMEQSLVQVAQATVSFSRAWKDGLSSADAYWVFPDQIKKGAPTGQFLPKGSFVIEGKRSYVKGVEVRLAIGIELINEREALVCGPEEAVKKRSLVYAVLLQGGLDPMNAAKKAKATLVSAAAGDNEELAETIKRISLDDFVRSLPTGQSKISFASKGSTSSKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MXT4</accession>
    <name>A0A075MXT4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03394</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701835.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MXT4"/>
    <dbReference type="STRING" id="1459636.NTE_03394"/>
    <dbReference type="GeneID" id="41599040"/>
    <dbReference type="KEGG" id="nev:NTE_03394"/>
    <dbReference type="HOGENOM" id="CLU_2597527_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="79" mass="9239" checksum="1FBD0905F2933CEF" modified="2014-10-29" version="1">MTCKGIHARFQGYRRQTAKKPDYHVEQWCKGCECTFDIGLYVKCPCCRFNLRSNPLHRDVKSRVPLEIRGRPMPTVTPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MXV2</accession>
    <name>A0A075MXV2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701858.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MXV2"/>
    <dbReference type="GeneID" id="41599063"/>
    <dbReference type="KEGG" id="nev:NTE_03419"/>
    <dbReference type="HOGENOM" id="CLU_1912246_0_0_2"/>
    <dbReference type="OrthoDB" id="384776at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="132" mass="14372" checksum="9C07D4646716D5B0" modified="2014-10-29" version="1">MSSSPSSSSPEEQRLWELRQDAKWGKDTETQKKAIQELGKVGTPPAVNVLNEVMAVSSRDDIKKYCQDVISGIIATTTNDIRTAGEERAAAEEAGTEKNQQPEKKKAAAAEKGKEKVEVSQEKRGTEVVGLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MYA8</accession>
    <name>A0A075MYA8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700850.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MYA8"/>
    <dbReference type="STRING" id="1459636.NTE_02185"/>
    <dbReference type="GeneID" id="41597907"/>
    <dbReference type="KEGG" id="nev:NTE_02185"/>
    <dbReference type="HOGENOM" id="CLU_2930029_0_0_2"/>
    <dbReference type="OrthoDB" id="13672at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="60" mass="7040" checksum="A805BC16DCAA3711" modified="2014-10-29" version="1">MKEGTSTKVLTKKEDKEYDRRKLIELGVDPEFLKFLSDEQARELLKAMLYLITKSQDGYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MYK2</accession>
    <name>A0A075MYK2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Matrixin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NTE_02291</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_075054099.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MYK2"/>
    <dbReference type="STRING" id="1459636.NTE_02291"/>
    <dbReference type="GeneID" id="41598006"/>
    <dbReference type="KEGG" id="nev:NTE_02291"/>
    <dbReference type="eggNOG" id="arCOG04994">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1217617_0_0_2"/>
    <dbReference type="OrthoDB" id="9634at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001818">
        <property type="entry name" value="Pept_M10_metallopeptidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00413">
        <property type="entry name" value="Peptidase_M10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M10 metallopeptidase" evidence="5">
        <location>
            <begin position="166"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF84344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="232" mass="26025" checksum="95EA5469C7F688E9" modified="2014-10-29" version="1">MLRVLVPAFLFIATLLSLVLFLPSASAVQYYKEQTDFTETKVPTSGFTWSDSLHVCIFKQAGVPNSYYAWAKLAVQEWRQALREYTGDQQGWTMTARYSPSELQMGGCNVRVHIYNTYKDFPEYPRQTGAYTAVQYTGGDAESANVYLSPQVLHGDGKTEIKLPNYAFRNSAVHEMGHVLGLGHMGTEKGYLMSPVFDYFEHSDQLPITTLELSALVGLYGTDGFERTISIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MZE5</accession>
    <name>A0A075MZE5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein predicted to be involved in DNA repair</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701159.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MZE5"/>
    <dbReference type="STRING" id="1459636.NTE_02575"/>
    <dbReference type="GeneID" id="41598270"/>
    <dbReference type="KEGG" id="nev:NTE_02575"/>
    <dbReference type="eggNOG" id="arCOG02757">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071770_0_0_2"/>
    <dbReference type="OrthoDB" id="42298at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006482">
        <property type="entry name" value="Cas7_Csh2/Csh2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05107">
        <property type="entry name" value="Cas_Cas7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="316" mass="35922" checksum="447149FAD5761758" modified="2014-10-29" version="1">MTKNINKEILFYYESRQNPNGDPGFENQPRLMPDDTILITDVRIKRTIRDYARDVLGETLFVDYDKDGNAVTADQRAKEIIGNIKGKDVIAELIQLTFDAPLFGALVTVRSDKGEDGGGDSHKLTGPVQFGLGRSVNKVRIINPTISGRFVGKKNEGQEKQYSTFGKFYSVEYALLKVHGAINPMNLGKYYSDNEARNRFEKVEEKLFECLWKGTNNLVTRSKFPQRSILYIEVSYDSTSYNDLPVLVNESQDMKQFATGLSKSPFDFERLIGTLVERKSRVKNVKIASCDDIREDVKLLLSRLRSKQIPVHEVEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MZZ3</accession>
    <name>A0A075MZZ3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Acetyl/propionyl-CoA carboxylase, alpha subunit</fullName>
            <ecNumber evidence="10">6.3.4.14</ecNumber>
            <ecNumber evidence="10">6.4.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NTE_02773</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SR1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="6.3.4.14" evidence="10"/>
    <dbReference type="EC" id="6.4.1.2" evidence="10"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701323.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MZZ3"/>
    <dbReference type="STRING" id="1459636.NTE_02773"/>
    <dbReference type="GeneID" id="41598462"/>
    <dbReference type="KEGG" id="nev:NTE_02773"/>
    <dbReference type="eggNOG" id="arCOG01590">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000395_3_2_2"/>
    <dbReference type="OrthoDB" id="31083at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004075">
        <property type="term" value="F:biotin carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000018">
        <property type="entry name" value="Biotin carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000010">
        <property type="entry name" value="Propionyl-CoA carboxylase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050856">
        <property type="entry name" value="Biotin_carboxylase_complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006367">
        <property type="entry name" value="PRK08591.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866">
        <property type="entry name" value="CARBOXYLASE:PYRUVATE/ACETYL-COA/PROPIONYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866:SF33">
        <property type="entry name" value="METHYLCROTONOYL-COA CARBOXYLASE SUBUNIT ALPHA, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0092">Biotin</keyword>
    <keyword evidence="2 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="9">
        <location>
            <begin position="4"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="8">
        <location>
            <begin position="123"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="482"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="482"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="493"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIF84814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="502" mass="55672" checksum="F4F6607D1945AFA5" modified="2014-10-29" version="1">MSKKITSILIANRGEIALRVIRACKELGIRSIAIYSDEDTRAVHVKRADEAYHIGPAPPAQSYLNMAKIVETAKMAGADAIHPGYGFLSENENFPEMCEKNGIIFIGPTAKAMDVTGDKMKCKAVMKKAKVPTVPGSDGIIEDVEKAANIAHEAGYPVMLKSAFGGGGRGIRLCKDEKQLRQEFEMASAESKAAFGKSALFVEKYLQRIRHIEFQLLRDSHGNGRHLFERECSIQRRHQKLIEMSPSPVVDQKTRERIGEIAVRAAAAVDYLNAGTAEFLRDPEGNFYFIEINSRLQVEHPVTELVTGLDLVKLQIHVAQGGEIPFKQEDLKMNGCAIECRINAEDPFYDFAPSTGAVPNCNIPYGPGVRVDTYLYPGCTVSGYYDSLVAKLLAWGSNFNEARIRMRNALDEFTIEGINTTIPLYKTIMTEPNFNKGEISTDYLDRFKVFDKMNEEVKAEASKNAQAAVAAALLQSELVKKTSQNNNNGQKASRWKMMRATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N0H4</accession>
    <name>A0A075N0H4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02948</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N0H4"/>
    <dbReference type="KEGG" id="nev:NTE_02948"/>
    <dbReference type="HOGENOM" id="CLU_2893048_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="62" mass="7249" checksum="B9D1316D56C21203" modified="2014-10-29" version="1">MSTNIIIYLSSFTTTVSRQNATRVGQELKNNSVCTHKNKRYLRMYDHVKFFPVTGTHQVQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N144</accession>
    <name>A0A075N144_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03167</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701636.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N144"/>
    <dbReference type="GeneID" id="41598825"/>
    <dbReference type="KEGG" id="nev:NTE_03167"/>
    <dbReference type="HOGENOM" id="CLU_2433700_0_0_2"/>
    <dbReference type="OrthoDB" id="7946at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="90" mass="9693" checksum="A435F4EC0BC8DB47" modified="2014-10-29" version="1">MGKSEQQLKSISVLVPLERVEASLSEIGFLLQDSATVVADGKFWKRLLYVRGDETISVSEEIGDAYPKDPIITICGSKSTITHVVKGVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N1N0</accession>
    <name>A0A075N1N0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701785.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N1N0"/>
    <dbReference type="STRING" id="1459636.NTE_03340"/>
    <dbReference type="GeneID" id="41598989"/>
    <dbReference type="KEGG" id="nev:NTE_03340"/>
    <dbReference type="eggNOG" id="arCOG01055">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_160435_0_0_2"/>
    <dbReference type="OrthoDB" id="9844at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038723">
        <property type="entry name" value="ArnR1-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14947">
        <property type="entry name" value="HTH_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ArnR1-like winged helix-turn-helix" evidence="1">
        <location>
            <begin position="6"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="98" mass="11616" checksum="EF9DC29B253BE523" modified="2014-10-29" version="1">MTHEYRDRIYIRKDIILKLTEVGELNQTKLLSYCGLNIVKHKEILDDLEAKGFIEKFAEEWGTKSVTKYRATEKGRQFSKMILEPYEEMFPRKGNKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N1T6</accession>
    <name>A0A075N1T6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03391</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701831.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N1T6"/>
    <dbReference type="STRING" id="1459636.NTE_03391"/>
    <dbReference type="GeneID" id="41599036"/>
    <dbReference type="KEGG" id="nev:NTE_03391"/>
    <dbReference type="HOGENOM" id="CLU_2313653_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="99" mass="11199" checksum="8D3F1A9BE922CBAE" modified="2014-10-29" version="1">MADQREFLNAKKGGHCDHCGSDGLLFVQRVVSGHSERYYGYVKHPAEFEDSKQVATAKRCYVGLLSKYITGRTCDHCGRRCKFSECYKCSRKRRAAVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N225</accession>
    <name>A0A075N225_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03471</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N225"/>
    <dbReference type="KEGG" id="nev:NTE_03471"/>
    <dbReference type="HOGENOM" id="CLU_2783849_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="68" mass="8017" checksum="33AE05E9F79E5653" modified="2014-10-29" version="1">MLLARYLLFDDAGSTFVFVYAYVYVVNRLRILRGKGEEVRSIGRALNSTAPSGYHHYQQRCRHHRHYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MKX7</accession>
    <name>A0A075MKX7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00012</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699167.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MKX7"/>
    <dbReference type="STRING" id="1459636.NTE_00012"/>
    <dbReference type="GeneID" id="41595966"/>
    <dbReference type="KEGG" id="nev:NTE_00012"/>
    <dbReference type="HOGENOM" id="CLU_2597870_0_0_2"/>
    <dbReference type="OrthoDB" id="372836at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="79" mass="9354" checksum="36B1A94238A9B7C4" modified="2014-10-29" version="1">MPASFVYGQVALEFQVESNRKAKAIVRYRYYAQENRVEYVSIDYTDPKLKEKVEGDPAMREKINEYVRRMLSKRNEGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLE4</accession>
    <name>A0A075MLE4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLE4"/>
    <dbReference type="STRING" id="1459636.NTE_00014"/>
    <dbReference type="KEGG" id="nev:NTE_00014"/>
    <dbReference type="HOGENOM" id="CLU_2645690_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="76" mass="8223" checksum="D82C242717E3386D" modified="2014-10-29" version="1">MIVAGAASGTLPSNAMSPAAVASIAAGSAIFLALIALVAHASYKRKKEQDWHIAEWHRAESEARTQRERPDKEMLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLP8</accession>
    <name>A0A075MLP8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00334</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLP8"/>
    <dbReference type="STRING" id="1459636.NTE_00334"/>
    <dbReference type="KEGG" id="nev:NTE_00334"/>
    <dbReference type="eggNOG" id="arCOG08812">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034350_1_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="473"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="517" mass="56215" checksum="B25FFA84F0382703" modified="2014-10-29" version="1">MTLRGLTLYSHCLWFEKNANAVIFLVIATLLFAAAGNLGQTVFLSQKAFADGLTQENLPPATFGNKQAALFVKINPPILTTESKQDAYLQFRLFDAKTNETIKYPNLLIAIYKGLDPKAKPLLQDAFVSQNGLLTLKVKPQPGDIQIQGNKDAFTNAWQADYGGTVNISGPVLLDGGLYRIDVSVLGIDYPQNLFADKDVKSFETALSVGDVFNQNVQSEGKTYPMSIISYYDKVEDFKFDANAKQYSWAMPFNWNTSRIQNAPNVFVHEEVRVPKSFTGVGDASAFDAKVNGKPIAGRMLAVDPFSDENNLILHFLINKNDILDMARNDPPADGKMTFAFSPAGASEGQQTSGEISTDTGGIHALLNWTPGQLKAGAETKLDIQFVDAFAGTNISDQDVKYDLKIFDKNGKAVVTKTDQTAQGGKGEQAGLNFPADDTYRVEITVKGLVKQGQSPDLTRNGIARGAVVVPEFPASASAFLAVGTAIGVVVFVQRRFGKRRLDREGGSNRGDIARTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MM61</accession>
    <name>A0A075MM61_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MYM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00123</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MM61"/>
    <dbReference type="KEGG" id="nev:NTE_00123"/>
    <dbReference type="HOGENOM" id="CLU_2433975_0_0_2"/>
    <dbReference type="OrthoDB" id="372849at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="93" mass="10963" checksum="1540D8250A325DC6" modified="2014-10-29" version="1">MVTMDATRCLRCDADLSTSAFFYTIARNSYMFGFFCSRDCAQESEHNKYLKATVLRIAHPPATHKDLVLTPDVKTLRQYTEELERRKIREKYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMN4</accession>
    <name>A0A075MMN4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative dinucleotide-binding enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_00013</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699168.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMN4"/>
    <dbReference type="STRING" id="1459636.NTE_00013"/>
    <dbReference type="GeneID" id="41595967"/>
    <dbReference type="KEGG" id="nev:NTE_00013"/>
    <dbReference type="eggNOG" id="arCOG00457">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076368_2_0_2"/>
    <dbReference type="OrthoDB" id="8635at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051267">
        <property type="entry name" value="STEAP_metalloreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14239">
        <property type="entry name" value="DUDULIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14239:SF10">
        <property type="entry name" value="REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase catalytic N-terminal" evidence="2">
        <location>
            <begin position="2"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF82097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="215" mass="23001" checksum="DC90A47075270EE4" modified="2014-10-29" version="1">MKVGIIGSGEVGQRLGDGFIELGHEVKIGTRDPQKLEAWVEKHSNNRKASSGSFAEAAEFGEDIIAIATLWTGTQSAIEMAGGPASFAGKVVIDVTNPLDYSSTPPRLAVGHTDSAGETVQRLLPDAKVVKAFNTVGNPLMLHPDFPGGRPTMFVCGNDDGAKKTVCDIAFSLGWETVDVGGIEGARLLEPLAMLWIVHYFRTNNGNHAFKLLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMQ8</accession>
    <name>A0A075MMQ8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphate ABC transporter ATP-binding protein, PhoT family</fullName>
            <ecNumber evidence="5">3.6.3.27</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_00043</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.27" evidence="5"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699192.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMQ8"/>
    <dbReference type="STRING" id="1459636.NTE_00043"/>
    <dbReference type="GeneID" id="41595995"/>
    <dbReference type="KEGG" id="nev:NTE_00043"/>
    <dbReference type="eggNOG" id="arCOG00231">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_2"/>
    <dbReference type="OrthoDB" id="31298at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03260">
        <property type="entry name" value="ABC_PstB_phosphate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005670">
        <property type="entry name" value="PstB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00972">
        <property type="entry name" value="3a0107s01c2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43423">
        <property type="entry name" value="ABC TRANSPORTER I FAMILY MEMBER 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43423:SF1">
        <property type="entry name" value="ABC TRANSPORTER I FAMILY MEMBER 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="29"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF82127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="276" mass="30550" checksum="32F1EAD2000EB530" modified="2014-10-29" version="1">MTTSEEYLSSSGSPSYEAQATSAKPGYKVSVQRLNSWFFDKQALKGINLDVKENTATALIGPSGCGKTTLIRSLNRMNEMTLGARVQGSVFLDDTDIYGRETDPVLIKRRIGMVFQKPNPFPTMSIFDNVAAGLKLNGIRDKKMLGEIVEESLKGAALWEEVKNELSKPGISLSGGQQQRLCIARALAMQPEVLLMDEPTSALDPIASSKIEELIHELKKDLTVIIVTHNMQQAARVSDYTAFMYLGELVEYGPTKQMFENPEKELTERYISGKFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMR1</accession>
    <name>A0A075MMR1_9ARCH</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00358</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699415.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMR1"/>
    <dbReference type="STRING" id="1459636.NTE_00358"/>
    <dbReference type="GeneID" id="41596250"/>
    <dbReference type="KEGG" id="nev:NTE_00358"/>
    <dbReference type="eggNOG" id="arCOG12009">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122242_0_0_2"/>
    <dbReference type="OrthoDB" id="387069at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="188" mass="20628" checksum="475162CC8190475B" modified="2014-10-29" version="1">MTETKVDTNSSKEGVYDAEKTAESVKEVAQKIKEASKAVRDTVKTFNESGAVTEVVEATRDAAVAARDSTRSARETTEEIQKSGVIEETARAMDETISDATKTAAAVQKTPKQFQKSAPKTTRAAKKGAKTAAKTGRKMEKQARSTLRKDKEKAKRNIRKITKNAKSASKKIRVKLNQANKAKNKKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MN44</accession>
    <name>A0A075MN44_9ARCH</name>
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        <recommendedName>
            <fullName evidence="1">Hemerythrin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00597</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987298.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MN44"/>
    <dbReference type="STRING" id="1459636.NTE_00597"/>
    <dbReference type="GeneID" id="41596460"/>
    <dbReference type="KEGG" id="nev:NTE_00597"/>
    <dbReference type="eggNOG" id="arCOG01471">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095978_2_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.520">
        <property type="entry name" value="nmb1532 protein domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39966">
        <property type="entry name" value="BLL2471 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39966:SF1">
        <property type="entry name" value="HEMERYTHRIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin-like" evidence="1">
        <location>
            <begin position="3"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="187" mass="22306" checksum="639120CC54411A08" modified="2014-10-29" version="1">MSTRELVQDHVTIRRIRDIAQKCSDRLYAGDHIPLEEIEIISVVIEEFVDAFHHGKEEKAYFPANERKNNEYAEEVRKFKIEHEFGRRVARMMLRSLKEWKNGVGDRREPVARFLRTYAAFVTDHTGKEERFFEMVEEAKSISSEEDRQILLHYKECRNDVGGSARVQELSRLVEYLEEREWMGRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MN90</accession>
    <name>A0A075MN90_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158384902.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MN90"/>
    <dbReference type="GeneID" id="43502539"/>
    <dbReference type="KEGG" id="nev:NTE_00185"/>
    <dbReference type="HOGENOM" id="CLU_3003280_0_0_2"/>
    <dbReference type="OrthoDB" id="374632at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="58" mass="6648" checksum="12CDD483F2EF0550" modified="2014-10-29" version="1">MAVKNPDVRAVLRDYAKLMELGVDQKFVEKLDANQAKELLKGILYVRAVWEDDEGKVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNA1</accession>
    <name>A0A075MNA1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pyruvate-formate lyase-activating enzyme</fullName>
            <ecNumber evidence="8">1.97.1.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NTE_00950</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <dbReference type="EC" id="1.97.1.4" evidence="8"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987167.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNA1"/>
    <dbReference type="STRING" id="1459636.NTE_00950"/>
    <dbReference type="GeneID" id="41596785"/>
    <dbReference type="KEGG" id="nev:NTE_00950"/>
    <dbReference type="eggNOG" id="arCOG00946">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044176_1_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043365">
        <property type="term" value="F:[formate-C-acetyltransferase]-activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027596">
        <property type="entry name" value="AmmeMemoSam_rS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034457">
        <property type="entry name" value="Organic_radical-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016431">
        <property type="entry name" value="Pyrv-formate_lyase-activ_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04337">
        <property type="entry name" value="AmmeMemoSam_rS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30352:SF5">
        <property type="entry name" value="PYRUVATE FORMATE-LYASE 1-ACTIVATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30352">
        <property type="entry name" value="PYRUVATE FORMATE-LYASE-ACTIVATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004869">
        <property type="entry name" value="PflX_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01101">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="74"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR004869-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF83026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="356" mass="39946" checksum="DBD1D4F71738D528" modified="2014-10-29" version="1">MMQGEVPGRDAELGVALPNGRVRCTACARYCEIPEGKTGLCGVRGVVDNKLRLFVYGRVIAGNVDPIEKKPVTHYQPGSSIFSIATTGCNWLCQYCQNYDISQRRKVEGTEMTPEQVVQAAETQGAQGMAYTYNEPSIFIEFARDCGIEAHKRGIFNIFVSNGYDTPESVNEMSKFLDCITVDFKGSGKQEFVRRYIGIPSADPIFQTLKEIKSKTKIHVEVTDLIVPKVGDDLEQAKKLCRFVHDELGPDTPIHFLRFHPDYKMMEFGLTPVETLEKHYQVAKNEGLTYAYLGNVPGHPLEDTYCPGCNSVAIGRYGFNVDEWNLDADNRCKTCGCKLPIVGTLHKQKRRFQFVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNF3</accession>
    <name>A0A075MNF3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">VapB-type antitoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699341.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNF3"/>
    <dbReference type="STRING" id="1459636.NTE_00255"/>
    <dbReference type="GeneID" id="41596167"/>
    <dbReference type="KEGG" id="nev:NTE_00255"/>
    <dbReference type="eggNOG" id="arCOG07235">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_175270_3_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="87" mass="10073" checksum="84C373F73B250830" modified="2014-10-29" version="1">MEVFSVKVDKRVKEKMKKFSHVNWSEIIRRALAAKIEEEEAKGASRTLDFDALSEAASLTDSIRKGTSSSKTWNSTEEIRRWREARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPA0</accession>
    <name>A0A075MPA0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10 11">Phosphoenolpyruvate carboxykinase (ATP)</fullName>
            <shortName evidence="10">PCK</shortName>
            <shortName evidence="10">PEP carboxykinase</shortName>
            <shortName evidence="10">PEPCK</shortName>
            <ecNumber evidence="3 10 11">4.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">pckA</name>
        <name evidence="12" type="ORF">NTE_01302</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>oxaloacetate + ATP = phosphoenolpyruvate + ADP + CO2</text>
            <dbReference type="Rhea" id="RHEA:18617"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.1.1.49"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="10">Binds 1 Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.49" evidence="3 10 11"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPA0"/>
    <dbReference type="STRING" id="1459636.NTE_01302"/>
    <dbReference type="KEGG" id="nev:NTE_01302"/>
    <dbReference type="eggNOG" id="arCOG06073">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018247_0_1_2"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004612">
        <property type="term" value="F:phosphoenolpyruvate carboxykinase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00484">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.449.10">
        <property type="entry name" value="Phosphoenolpyruvate Carboxykinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.8.10">
        <property type="entry name" value="Phosphoenolpyruvate Carboxykinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00453">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001272">
        <property type="entry name" value="PEP_carboxykinase_ATP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013035">
        <property type="entry name" value="PEP_carboxykinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008210">
        <property type="entry name" value="PEP_carboxykinase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00224">
        <property type="entry name" value="pckA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006820">
        <property type="entry name" value="PRK09344.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006821">
        <property type="entry name" value="PRK09344.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30031:SF0">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYKINASE (ATP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30031">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYKINASE ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01293">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006294">
        <property type="entry name" value="PEP_crbxkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68923">
        <property type="entry name" value="PEP carboxykinase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53795">
        <property type="entry name" value="PEP carboxykinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="4 10" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-0464">Manganese</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="10">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="229"/>
            <end position="237"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="440"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="NCBIfam" id="TIGR00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIF83371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="523" mass="57767" checksum="7C9720A9A1FC7860" modified="2014-10-29" version="1">MMIELATLDIKLVKAHMNLPVPALVEMILQSKEGVLSSTGALSVRTGKFTGRSPDDKFLVDDDVTHGTVDWGKVNRPISEENFDKIYRRMKKHIEDKELFVFDGYVGADPENRLPIRVINNRAWHNLFARQIFIRPDNSGELDGFKPEFTLISADDFAANPASEGTRTETFIIVNFKRKIVLIGSTSYAGEIKKAMFSIMNFLLPRKGIFPMHCSANVGKGGDVALFFGLSGTGKTTLSADPERRLVGDDEHGWSDNGVFNFEGGCYAKCINLKKEHEPQIWNAIKFGSLMENVVITDGAREPDFADGSLTENTRVVYPLDFIDGAIIPSVAGHPKVIIFLTADAFGVMPPIAKLTKEGAMYHFMSGYTSKLAGTERGITEPKETFSQCFGGPFMPLHAQQYAKLLGKKMDEHGTRVYLINTGWTGGPYGIGKRMNLSYTRAMVTAALSGDIEKSPVKHHDIFNLDMPTSCPGVPPEVLDPRNTWHDKDKYDAAAKRLAALFAKNFEKFGSVSKEIASAGPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPA1</accession>
    <name>A0A075MPA1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00909</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPA1"/>
    <dbReference type="KEGG" id="nev:NTE_00909"/>
    <dbReference type="eggNOG" id="arCOG08805">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100103_1_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="205" mass="24361" checksum="5454EAF3C6901307" modified="2014-10-29" version="1">MTIWKEKVYLASQNHTQQRYHRPRHLAYPTEAATFRFDKKLLAQLRLESKEKRINLNTVLNQIVRSHIEWHANAAKAGFMPIRKALIKRLFDPMTKEQIDALAADVSRGLIEETMMIIMTSQRTEEPVFELLERWIRVSGFNYRHEVTDDSHIFVIQHNMGENWSHYMGRLFEEAASEFMRVKPDTQVTENALFIRIREVYDKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPA2</accession>
    <name>A0A075MPA2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00963</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPA2"/>
    <dbReference type="STRING" id="1459636.NTE_00963"/>
    <dbReference type="KEGG" id="nev:NTE_00963"/>
    <dbReference type="eggNOG" id="arCOG08733">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_707136_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="390" mass="41895" checksum="CA2A2058700836F3" modified="2014-10-29" version="1">MESRYFAFSAIAAVLVFGVLASVMSVKSAYAADDLWYVGEGAKQDTYVKYRIQEYDTNNDAPFDMTIYFKGKDDRGAWIAPTFVEYQGNVYNGTLRLGDNLAALGGGSQVPDDMRPFVGAYGRSLQWLEAFTSVSAPLSLKAGSWGKIAAIGGEELKPQGQQKVTVPAGTFDTTVVGWHKGVDNKIWIENEFPFPIKAETFVEVASGKPPIQFKFDLLATGTGQPPVPKSVEEIPQPPLRQSTARGTYDVTLSWNPVEIQPNGNTTFTVDFADNNGQKLERVNYDFTVTEKGGKVIYDKKNAFTGESSTGVQTVKMGNGGPVSISIVLHSVSGVNTGAFTEEADFGVVVVPEFPVSAAIIAAIAVAFIVAMTRFKGIGIGGMFGGRNSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPD9</accession>
    <name>A0A075MPD9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00576</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699584.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPD9"/>
    <dbReference type="GeneID" id="41596442"/>
    <dbReference type="KEGG" id="nev:NTE_00576"/>
    <dbReference type="eggNOG" id="arCOG09752">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119855_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="132" mass="13492" checksum="60663ED5D752E58C" modified="2014-10-29" version="1">MSISTSSRPMGVTILAILNVIGGIVMLLVGLGVAVLGVALIFLAPVGIFFGGIFAILGIVSFVVAGGLLQGSGWAWTATLILSIISIVIGVASLAAGNASSIISVIISAAIIYYLYRPYVMAYFGKSTKRIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPK1</accession>
    <name>A0A075MPK1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Diadenosine 5',5'''-P1,P4-tetraphosphate asymmetrical hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NTE_00652</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699643.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPK1"/>
    <dbReference type="STRING" id="1459636.NTE_00652"/>
    <dbReference type="GeneID" id="41596513"/>
    <dbReference type="KEGG" id="nev:NTE_00652"/>
    <dbReference type="eggNOG" id="arCOG01078">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037162_14_4_2"/>
    <dbReference type="OrthoDB" id="25379at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004081">
        <property type="term" value="F:bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006167">
        <property type="term" value="P:AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006754">
        <property type="term" value="P:ATP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03428">
        <property type="entry name" value="NUDIX_Ap4A_Nudt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051325">
        <property type="entry name" value="Nudix_hydrolase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003565">
        <property type="entry name" value="Tetra_PHTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21340:SF0">
        <property type="entry name" value="BIS(5'-NUCLEOSYL)-TETRAPHOSPHATASE [ASYMMETRICAL]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21340">
        <property type="entry name" value="DIADENOSINE 5,5-P1,P4-TETRAPHOSPHATE PYROPHOSPHOHYDROLASE MUTT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="6">
        <location>
            <begin position="4"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF82732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="147" mass="16806" checksum="88D621B5CE3C0BCC" modified="2014-10-29" version="1">MVDERSAGAVVFIMSSNGSGKPEYLLLHYTAGHWDFPKGNIEAGETEKEAAAREIREETGIADVEFVEGFRQIISYRYRKARRLVNKEVVLFLARTKTRDVTISHEHIGFAWKDYDEAMKQLTYKNAKSLLEAAAQFMMKKEKQQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPT8</accession>
    <name>A0A075MPT8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">C2H2-type zinc finger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01067</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPT8"/>
    <dbReference type="STRING" id="1459636.NTE_01067"/>
    <dbReference type="KEGG" id="nev:NTE_01067"/>
    <dbReference type="HOGENOM" id="CLU_3210584_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="3"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="44" mass="5254" checksum="1B10D580BA43F2B5" modified="2014-10-29" version="1">MAFKCNKCDMEFDDKERLERHKQVHGRKPKVRYAGEINFDQVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPW6</accession>
    <name>A0A075MPW6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ATP-utilizing enzymes of ATP-grasp superfamily (Probably carboligase)</fullName>
            <ecNumber evidence="12">6.3.4.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NTE_00824</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SR1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="6.3.4.-" evidence="12"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699778.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPW6"/>
    <dbReference type="STRING" id="1459636.NTE_00824"/>
    <dbReference type="GeneID" id="41596668"/>
    <dbReference type="KEGG" id="nev:NTE_00824"/>
    <dbReference type="eggNOG" id="arCOG04346">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065084_0_0_2"/>
    <dbReference type="OrthoDB" id="84677at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006188">
        <property type="term" value="P:IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023656">
        <property type="entry name" value="IMP_biosynth_PurP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009720">
        <property type="entry name" value="IMP_biosynth_PurP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010672">
        <property type="entry name" value="IMP_biosynth_PurP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38147:SF1">
        <property type="entry name" value="5-FORMAMINOIMIDAZOLE-4-CARBOXAMIDE-1-(BETA)-D-RIBOFURANOSYL 5'-MONOPHOSPHATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38147">
        <property type="entry name" value="5-FORMAMINOIMIDAZOLE-4-CARBOXAMIDE-1-(BETA)-D-RIBOFURANOSYL 5'-MONOPHOSPHATE SYNTHETASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06849">
        <property type="entry name" value="DUF1246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06973">
        <property type="entry name" value="DUF1297"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004602">
        <property type="entry name" value="ATPgrasp_PurP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IMP biosynthesis enzyme PurP N-terminal" evidence="10">
        <location>
            <begin position="21"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="IMP biosynthesis enzyme PurP C-terminal" evidence="11">
        <location>
            <begin position="179"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIF82902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="366" mass="41906" checksum="88558A04138A642A" modified="2014-10-29" version="1">MIGQQQIAPIIDRYDPKHVTIGAIGSHSALEVMDGAKDEGMKTICICQKGRDLPYRRFKRLADEIIILDKFSDILNRENQEKLRDRNCIMVAHRAFTAYLGYDNIENNFKVPVFGNRALLRAEERTAPRNQYYLIEKAGLRHPRIYRKPSDIAGPAMVKVQEAKRKLERAFFIVTSYEDYKRKAKQKVEQGIISKQDLENAVIEEYVLGTYFNLNFFHSPITGETEFLGIERRLQTNLHDFVSIPARQQMEIENIQTQNIEVGHTPASIRESLLEKVFEMGDKFAVAARKEYPPGIIGPISLQSIVTTDLDFVVYDVSLRVPGNPIMATTSPYTKYYYGHTMGVGRRIAMEIKNAAAQRKLRDIVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPX9</accession>
    <name>A0A075MPX9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptidase family M50/AN1-like Zinc finger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NTE_00846</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699793.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPX9"/>
    <dbReference type="STRING" id="1459636.NTE_00846"/>
    <dbReference type="GeneID" id="41596689"/>
    <dbReference type="KEGG" id="nev:NTE_00846"/>
    <dbReference type="eggNOG" id="arCOG00614">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG01769">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055068_1_0_2"/>
    <dbReference type="OrthoDB" id="26567at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052348">
        <property type="entry name" value="Metallopeptidase_M50B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35864">
        <property type="entry name" value="ZINC METALLOPROTEASE MJ0611-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35864:SF1">
        <property type="entry name" value="ZINC METALLOPROTEASE YWHC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00154">
        <property type="entry name" value="ZnF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="AN1-type" evidence="5">
        <location>
            <begin position="3"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF82922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="268" mass="29668" checksum="94D07884C033E45C" modified="2014-10-29" version="1">MECGICGREEEIPFRCRYCKGYFCSEHRLPPNHNCLFINDFMRQPEKDREFVEYVSGMGGGSVGERAANIVKNTVLLRFSKTEIAHLAIGMTLVAAVGMSLFGFRFQPAYIAIFVSAFLLHELAHKFLAQFYRAWAEFRVIFFGAIVTAMSALPFFPFKFIAPGAVFISGSISERRNGKISLVGPLTNVALCTGMLLAFMLSDSPSQLLVVGARFNAWIAIFNLIPFMGLDGQKIFAWNKLVWVLTLAASALLYIAVGFASGRGLGFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQ77</accession>
    <name>A0A075MQ77_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01269</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQ77"/>
    <dbReference type="KEGG" id="nev:NTE_01269"/>
    <dbReference type="HOGENOM" id="CLU_210682_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="58" mass="6524" checksum="30B2249EA19EB267" modified="2014-10-29" version="1">MYERLRSLGVNVETLKKFNLTDEELLDFANRLTKLVNKSTGGILLVILGLVFGTTLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQE3</accession>
    <name>A0A075MQE3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700201.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQE3"/>
    <dbReference type="STRING" id="1459636.NTE_01360"/>
    <dbReference type="GeneID" id="41597158"/>
    <dbReference type="KEGG" id="nev:NTE_01360"/>
    <dbReference type="eggNOG" id="arCOG00472">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_502164_0_0_2"/>
    <dbReference type="OrthoDB" id="7690at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="542" mass="60248" checksum="C0217FEB012B01B5" modified="2014-10-29" version="1">MYPYRLDKNPYPSSPTPTLIDAKILGGKRHKEAKAAVLSCFSDLHGKVVEGKATDKDFRLLTIIQDVGSGKTHLALHIKGLKEVEDSTVISYVDLTQISPRNMHSLYSAMLGGFTDEYITHMRRAVVKYLLAKAEQSSTARKIFNYGFMDSITGRRLSDKAELLLSNELVPNYSALSATLGKEFSPIEVAILKLVVEGKFRADAANVSTLEDIIASLAALASLNLRFLGRVTVFQLDEFDADRETTEFVKAVINAHVPAAALMLIFTPSSYDDISKANASVFDRLEKANYKVDLAGSNTYEEILDIIMEYIRFHDASKCFTEDEERDLAAKVKVIYDEFPDFRNVRSMLNIMYHATENAGKREASIIDEQAIDETIKNVYPGLRIRGSVMDVPISDFIKIRRSTNDVSVLESGVKDAVRNLVNYAHEVGAVAKPQKSNGSGVDVMFSDPYGTKVAITVVINRDHAKSFEQISNTLKTTGFVDKLVILTNANTTAGTNGNAVVTMDRCKMIDLIYFSNKYKNNEMMEDDSQRALMLAKSIRIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQJ8</accession>
    <name>A0A075MQJ8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01429</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700253.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQJ8"/>
    <dbReference type="STRING" id="1459636.NTE_01429"/>
    <dbReference type="GeneID" id="41597224"/>
    <dbReference type="KEGG" id="nev:NTE_01429"/>
    <dbReference type="HOGENOM" id="CLU_745146_0_0_2"/>
    <dbReference type="OrthoDB" id="12264at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="206"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="272"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="371" mass="37608" checksum="2641E6C1B93DD86A" modified="2014-10-29" version="1">MKVNKPIAFVVLAFVIGATISQGSFAFADDSSTNPFRAIWEAIGELQTKTDSLQAQIDDIKTQQQQEGASPSAAGQAVTKNSETSLSIDLSGGQPGQTLISLVARNAGPDSAVGVKLSTYYQMSLFRVNHIDGAQCTDQARGIIECYLGTIESGGEARITIDATTLQIGQQAIITADASSITKDVNPGNNHAETVFVTAPQVVEIPPSQQQQQPTVEQPAQSIGEQQEQQQQPVQNQTSTQQENQSEQPAAEQQPNGQSSSGEQQNPGEQTSQPGSEQQNSGSEGASGSSGDSSNPSSSDNNSTAGSDSGSSDSSSTSSPGSSSSDTGSSDAGSGSSGDSGSTGDSSSGDSSSGEGSSSSGSSSDSGTTTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQN1</accession>
    <name>A0A075MQN1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NHL repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_01327</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700173.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQN1"/>
    <dbReference type="STRING" id="1459636.NTE_01327"/>
    <dbReference type="GeneID" id="41597126"/>
    <dbReference type="KEGG" id="nev:NTE_01327"/>
    <dbReference type="eggNOG" id="arCOG03561">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG03562">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013730_1_0_2"/>
    <dbReference type="OrthoDB" id="9006at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd14951">
        <property type="entry name" value="NHL-2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013211">
        <property type="entry name" value="LVIVD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045302">
        <property type="entry name" value="NHL2_NHL_rpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46388">
        <property type="entry name" value="NHL REPEAT-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46388:SF2">
        <property type="entry name" value="NHL REPEAT-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08309">
        <property type="entry name" value="LVIVD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13905">
        <property type="entry name" value="Thioredoxin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="10"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF83395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="507" mass="56017" checksum="0496342C5B758453" modified="2014-10-29" version="1">MFRRMAGNVTNSMTKAQEFPEGFAWLNTEKPLSMASLKGHVVVLDFWTYCCINCMHTLPTLDWLEKKYRGQPVVFIGVHSAKFSNEQQAQNVQEAIGRYEIGHPVVVDQEMKIWRSYNVSAWPTIVIIDPKGNVVYQQAGEGQRDELDDVIGVLLERHRAAGTLAQEPISIEHPRRAQGRVLSYPGKLAFSPDGRMLAISDSNHNRVLVADAQSGKIIHKVGGTVRDLRDGSFEEARFFRPQGLAWAKEDRIFVADTENHALREIDISAKTVRTLAGNGRQGAWISGAQDGKVTQLSSPWDLAYSDGFLFIAMAGLHQIWAYHIESGKIGPFAGSGYENIVDGTFSEAQFAQPSGLSIYDSNFLLVADSEVSAVRLLNLSKKTVQTVVGEGLFEFGFKDGALADARLQHPLGVHCAGNKIYVADTYNHAVRLIDLDTQQVSTVVGKAAGEKTMCKIDDPACDTLGLFEPSDVKQQGNTLYIADTNNHLVRMFDLDKMVLKTLAIKET</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQQ8</accession>
    <name>A0A075MQQ8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01124</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700007.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQQ8"/>
    <dbReference type="GeneID" id="41596938"/>
    <dbReference type="KEGG" id="nev:NTE_01124"/>
    <dbReference type="eggNOG" id="arCOG02038">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_766412_0_0_2"/>
    <dbReference type="OrthoDB" id="10207at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051797">
        <property type="entry name" value="TrmB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34293">
        <property type="entry name" value="HTH-TYPE TRANSCRIPTIONAL REGULATOR TRMBL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34293:SF1">
        <property type="entry name" value="HTH-TYPE TRANSCRIPTIONAL REGULATOR TRMBL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="362" mass="40597" checksum="38FDFBA40DA71FF9" modified="2014-10-29" version="1">MGRGSSSLPPSSYSDPVADNEEFVVLADEPGTIIFSLLSDASNKIDFCLDPLARFGQAANAKQLAVFFADLKKKNLQLRVITSITKDTSAALKQLIKYADVYHAEGQIASSFCIVDGSMYICHADGGEEGHPSQALLTRRPQFVRMQQYLFDSLLGRTVPAKDKLREIERGIQSEFIDTIREPSKALHLAKALIDSATFDVLILFSTINSFYRAEKDGILDLLGEASGRGAAVKVLVKVDDETMKDTYKQKIKQKHDRINVAFIEKAVKSKITTLVIDQTYSLAIEVSDDAKSTFSDATGLATYSNSESTVFTYYSMFENLWIQAELERQSKVRNAYFHMFKGQKLRDEIYRRDWKTDADNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQY7</accession>
    <name>A0A075MQY7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Kef-type K+ transport system, predicted NAD-binding component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NTE_01565</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family.</text>
    </comment>
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        <property type="protein sequence ID" value="AIF83628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700364.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQY7"/>
    <dbReference type="STRING" id="1459636.NTE_01565"/>
    <dbReference type="GeneID" id="41597347"/>
    <dbReference type="KEGG" id="nev:NTE_01565"/>
    <dbReference type="eggNOG" id="arCOG01955">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005126_1_2_2"/>
    <dbReference type="OrthoDB" id="43518at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42751">
        <property type="entry name" value="SODIUM/HYDROGEN EXCHANGER FAMILY/TRKA DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42751:SF3">
        <property type="entry name" value="SODIUM_GLUTAMATE SYMPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="272"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="8">
        <location>
            <begin position="16"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF83628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="388" mass="40725" checksum="765C9042552C4D00" modified="2014-10-29" version="1">MAVGIELVGDLGFLLLVCSGIGALAYIFKQPMILGFLVAGILIGPFGPLKLVQNTEMLNNFSDIAIVLLLFGVGLSFPLRQLRAIGKLGTGIAVIEVLAMLGIGFAVGAGFGWSFYDSMFLAAALSISSTAIIVKVLEDMGKMEATSSILMIGVLVIEDLVAVVMISAMHAGVVSGSFDFMQILVTIGQIGLFIGGTIAAGVILMPKIFALIARLERYEITVMFALGTAFGLAFLSHELGFSAATGAFLAGVIIAGTRFSEQVSNLITPTREIFTAIFFVTIGALMDLSTISLFWVPVAIITAVTVLGKMGAVYAGVRVFGFEKTFAIGIGLSMAQLGEFSFIVLKTGQDLGVVSPFLFPIVGMVVALTTFIGPMLVKLGTRAVAVYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MR25</accession>
    <name>A0A075MR25_9ARCH</name>
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        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AIF83267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="GeneID" id="41597004"/>
    <dbReference type="KEGG" id="nev:NTE_01195"/>
    <dbReference type="eggNOG" id="arCOG01117">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_170329_2_2_2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription regulator AsnC/Lrp ligand binding" evidence="1">
        <location>
            <begin position="14"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="76" mass="8613" checksum="5D5EA7C3732C1A1F" modified="2014-10-29" version="1">MPKAFVLMNAELGSEDSLVSELKKMEGIKEVYQVYGVYDIVAQVEAEAMEKVKETITWKLRKLNGVKSTLTMIVME</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MR74</accession>
    <name>A0A075MR74_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01532</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83595.1"/>
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    </dbReference>
    <dbReference type="RefSeq" id="WP_148700339.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MR74"/>
    <dbReference type="STRING" id="1459636.NTE_01532"/>
    <dbReference type="GeneID" id="41597319"/>
    <dbReference type="KEGG" id="nev:NTE_01532"/>
    <dbReference type="eggNOG" id="arCOG08750">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_175266_0_0_2"/>
    <dbReference type="OrthoDB" id="8274at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="106" mass="12355" checksum="415E10E699BD8CFE" modified="2014-10-29" version="1">MDASAKRFLYQQILWLGIYFAISIVITMFIDFPYSLMVLLPVIFGIAYYRRYRFMKQIGRQQGSLFRNPFDQKNEGGVHYYCINCGTKHNKVSCPNCGSKMKKAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRB7</accession>
    <name>A0A075MRB7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cytochrome b subunit of the bc complex</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">NTE_01577</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700373.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRB7"/>
    <dbReference type="STRING" id="1459636.NTE_01577"/>
    <dbReference type="GeneID" id="41597357"/>
    <dbReference type="KEGG" id="nev:NTE_01577"/>
    <dbReference type="eggNOG" id="arCOG01721">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_515465_0_0_2"/>
    <dbReference type="OrthoDB" id="55795at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.810.10">
        <property type="entry name" value="Cytochrome Bc1 Complex, Chain C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005798">
        <property type="entry name" value="Cyt_b/b6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036150">
        <property type="entry name" value="Cyt_b/b6_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005797">
        <property type="entry name" value="Cyt_b/b6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027387">
        <property type="entry name" value="Cytb/b6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016174">
        <property type="entry name" value="Di-haem_cyt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19271">
        <property type="entry name" value="CYTOCHROME B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19271:SF16">
        <property type="entry name" value="CYTOCHROME B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00032">
        <property type="entry name" value="Cytochrom_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00033">
        <property type="entry name" value="Cytochrome_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81648">
        <property type="entry name" value="a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81342">
        <property type="entry name" value="Transmembrane di-heme cytochromes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51003">
        <property type="entry name" value="CYTB_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51002">
        <property type="entry name" value="CYTB_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="38"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="393"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b/b6 N-terminal region profile" evidence="12">
        <location>
            <begin position="14"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b/b6 C-terminal region profile" evidence="13">
        <location>
            <begin position="241"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="449"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="451"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="489"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AIF83640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="546" mass="60497" checksum="5223223A0B7668C9" modified="2014-10-29" version="1">MGASLTYENSLTRFFRWVYAGVERTIFMGMKFTFPGRFVSPLGFLGMLTFVVFIILGITGALLMLWYEPILDRAWNSVKNINDTIPYGFHIRNIHYHASNGMVMLALLHMYYQYFSGRYKIRNEILWVTGIILGVLTILEAFTGYDIIFSERAELAISIAASLTNSIPIMGPQMREAFFGAGFHDFILRFYTFHVFMLPIALLGLMVVHFPRFLVFDVPMVMAIAGAIMLTGGVFPVGLGLPFDPHVPPGITVPEWYLTGLYAFLRTMYDKFVTGVAWPGLFIGALLLIPFVDRYKKFSWKDRPIITAVGITSLAQILVTTYWGFYIDPDTHKALLERLVIDPIFFYLVMVVLVPLSFGFTYMMIKLAKHAEANAKAQPKKAGKSSIELSQKWLYALFVVLIGFQVYLNIAAYYAMLDGMKNYSLFIVGIMMLVFAGMFHLYRYGKAQAKAPPPRPTPPAPKPAVAPPRPSPATPTPQEKPLAAPPAAQPAAKPAEKPAQLPPQKTATGGQTTQTAPGTKAAAAAPTTTGKAENNPTTDVKGPKGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRE2</accession>
    <name>A0A075MRE2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01662</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRE2"/>
    <dbReference type="STRING" id="1459636.NTE_01662"/>
    <dbReference type="KEGG" id="nev:NTE_01662"/>
    <dbReference type="HOGENOM" id="CLU_156998_0_0_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="133" mass="14651" checksum="6150984F96085639" modified="2014-10-29" version="1">MMGFSGINNPFCTSKIVDHPPYGARFAGLAADNTTLSIADVFDVGEGDTVADAWLTTVNLLDMLEHTHRIEGLYDFAQARDKIAKVYAVAEAHSMDSKNKCACGLSDAEHAILKRKVLTFFRLQVSNLKRFIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRM4</accession>
    <name>A0A075MRM4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700515.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
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    <dbReference type="STRING" id="1459636.NTE_01752"/>
    <dbReference type="GeneID" id="41597522"/>
    <dbReference type="KEGG" id="nev:NTE_01752"/>
    <dbReference type="eggNOG" id="arCOG10587">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_165240_0_0_2"/>
    <dbReference type="OrthoDB" id="12901at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="123" mass="12760" checksum="0C5FB38681920B4A" modified="2014-10-29" version="1">MNKPIVVALSVLAVFFSATAVSALPVAHAQYGVGGSPVAGATKEQLQECDQLGIAKSECTENAILAKRRIIAVQDNVNNPDKGSGTNYFQGSETWIYIGVLGAIFGGVAAAFFFRGRGATPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRQ1</accession>
    <name>A0A075MRQ1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF8156 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRQ1"/>
    <dbReference type="STRING" id="1459636.NTE_00005"/>
    <dbReference type="KEGG" id="nev:NTE_00005"/>
    <dbReference type="eggNOG" id="arCOG07300">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2581212_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058469">
        <property type="entry name" value="DUF8156"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26485">
        <property type="entry name" value="DUF8156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8156" evidence="1">
        <location>
            <begin position="3"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF26485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="80" mass="9582" checksum="D5EA1B1ECDA3BB30" modified="2014-10-29" version="1">MYEEAEWKPFRNTLSKSERKEFDRMFATSRLYISACSYAAKPIRIQPIFMAIIFHHYRQLVEISEKLEIKEVPVSEPISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRR3</accession>
    <name>A0A075MRR3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ethanolamine utilization protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_01792</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRR3"/>
    <dbReference type="STRING" id="1459636.NTE_01792"/>
    <dbReference type="KEGG" id="nev:NTE_01792"/>
    <dbReference type="HOGENOM" id="CLU_2419874_0_0_2"/>
    <dbReference type="OrthoDB" id="190812at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AraC-type arabinose-binding/dimerisation" evidence="2">
        <location>
            <begin position="2"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF83853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="91" mass="10319" checksum="1DE33DCE9B1AD013" modified="2014-10-29" version="1">MLEGEYSVRYGEKTVLAKAGDFVFIPKETPHNYQSGPEGGKVLVISPASLERYFADVASVLKERPITWEMEQEIARKYGQEFLDGLKHRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRU4</accession>
    <name>A0A075MRU4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Single-stranded DNA-specific exonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_01754</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042622_0_0_2"/>
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    </dbReference>
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        <property type="term" value="F:exonuclease activity"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SINGLE-STRANDED-DNA-SPECIFIC EXONUCLEASE RECJ"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SINGLE-STRANDED-DNA-SPECIFIC EXONUCLEASE RECJ"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DHH phosphoesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHH-CID" evidence="2">
        <location>
            <begin position="205"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="DHHA1" evidence="1">
        <location>
            <begin position="404"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF83815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="482" mass="51421" checksum="79BA6FFB368610DE" modified="2014-10-29" version="1">MGDGDSSKLLSALKPFCEKLRSVVESGSEISVITHLDADGITSGSIIGTALARMGAKCSVRTVSDMTPSVIEQMKAEDHEFYVVTDLGGGMAANFRKALGDRWVVIDHHQIPEEEILTDDAGQVLNAWKYGIDGGIEVPAGGMAYMVASTLDRKNRDLSPVAVVSAVGDRQDQGDKKSFLGLNKAILETAKTLGLVNVDLDIMLTGRETRPLHEALAFTSFPYIDGLTWNRDNCHALLKGAGIKLKDGNGRWRVPAEFSQEEKSAILDAIAKFVVTSSKTSATVIDDLVGYVYTLAGEDKRSQLRDAREFSTLLNACGRIGRSGVGIAICMGDRNAMLTAGEEISTEYRTTLRNYISTIFSEKWRVSDDGKMALINGDGLVAEDMLGAVSSLLSGSPTLAGRLVFVRSLSKDGTYKFSSRKGLGCTSPANLGLVMRHCAESVKGTGGGHSAAAGCRIPSTTLDPFLSCLRSAVNDAKFATAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRY7</accession>
    <name>A0A075MRY7_9ARCH</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01873</name>
    </gene>
    <organism evidence="1 2">
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        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
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    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.410">
        <property type="entry name" value="Protein of unknown function UPF0759"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR002763">
        <property type="entry name" value="DUF72"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036520">
        <property type="entry name" value="UPF0759_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30348:SF4">
        <property type="entry name" value="DUF72 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30348">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YECE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01904">
        <property type="entry name" value="DUF72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117396">
        <property type="entry name" value="TM1631-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="100" mass="11293" checksum="DDC7606517671C00" modified="2014-10-29" version="1">MQASLTLLKSTAPFTPCQIPLAVKRWAKNTPVDFRYTAKMHRVITHAKAMSNCDQQLETFYSAVALLREKLLCILIQLPSSIGFKTGFRALQNFGNIYSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRZ0</accession>
    <name>A0A075MRZ0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator with CheY-like receiver domain and winged-helix DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_00090</name>
    </gene>
    <organism evidence="3 4">
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        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
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            <taxon>Nitrososphaerota</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="41596036"/>
    <dbReference type="KEGG" id="nev:NTE_00090"/>
    <dbReference type="eggNOG" id="arCOG02391">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_8_2"/>
    <dbReference type="OrthoDB" id="8127at2157"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR050595">
        <property type="entry name" value="Bact_response_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44591:SF3">
        <property type="entry name" value="RESPONSE REGULATORY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44591">
        <property type="entry name" value="STRESS RESPONSE REGULATOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="4"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF82174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="123" mass="13855" checksum="A2A30DFE06DA03D6" modified="2014-10-29" version="1">MVRSVLLVDQKQSTAELVKTYLTADGYEVDHTPDPSKAVEYASRSQYGVVVTDLVMRGGMSGIDLYREIRSYDVQVRFVFMLVLSADVLRLMGSLERSDVIKKEPLSMNEVICKVRAAFTNSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MS04</accession>
    <name>A0A075MS04_9ARCH</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01889</name>
    </gene>
    <organism evidence="1 2">
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        <lineage>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MS04"/>
    <dbReference type="KEGG" id="nev:NTE_01889"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="43" mass="4734" checksum="B8E7533700CD5DB7" modified="2014-10-29" version="1">MKGLASFDPTFKISKQVISVETLYLPLPFFVGSCKSVTGFVLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSJ2</accession>
    <name>A0A075MSJ2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02038</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
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        <lineage>
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            <taxon>Nitrososphaerota</taxon>
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            <taxon>Nitrososphaerales</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385325.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSJ2"/>
    <dbReference type="GeneID" id="43502635"/>
    <dbReference type="KEGG" id="nev:NTE_02038"/>
    <dbReference type="HOGENOM" id="CLU_3162929_0_0_2"/>
    <dbReference type="OrthoDB" id="376065at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="47" mass="5316" checksum="200476C954F2EA59" modified="2014-10-29" version="1">MQTAAVEEQQQERTVFCETHSKKCRFVSQGAKCACCGKRVCLCNYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSM0</accession>
    <name>A0A075MSM0_9ARCH</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00262</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSM0"/>
    <dbReference type="STRING" id="1459636.NTE_00262"/>
    <dbReference type="KEGG" id="nev:NTE_00262"/>
    <dbReference type="HOGENOM" id="CLU_2461613_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="88" mass="9807" checksum="38C965434CE2F9EA" modified="2014-10-29" version="1">MFTVTTGGWLKLSAQLPSSYPLAKDRPCALARARCSLVRSERATVSASEKGVEISKEKKRAVARTCDRLWRKGFSVETIQEIYDTADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSN8</accession>
    <name>A0A075MSN8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02113</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSN8"/>
    <dbReference type="STRING" id="1459636.NTE_02113"/>
    <dbReference type="KEGG" id="nev:NTE_02113"/>
    <dbReference type="HOGENOM" id="CLU_2695534_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="73" mass="8041" checksum="12FFA62C2538D3AF" modified="2014-10-29" version="1">MTIERVSSARGRNDKPDFRVKVSYRKGKTRGTIAWPATILDAWGYPEYLVFAGNGDGSAIVRPVAKEKVGVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSU8</accession>
    <name>A0A075MSU8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01801</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSU8"/>
    <dbReference type="STRING" id="1459636.NTE_01801"/>
    <dbReference type="KEGG" id="nev:NTE_01801"/>
    <dbReference type="HOGENOM" id="CLU_196449_0_0_2"/>
    <dbReference type="OrthoDB" id="383243at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="79" mass="8542" checksum="8356AE94655396ED" modified="2014-10-29" version="1">MFSIKKWKANQKIGKMARIGVFALAGLFASIFVFGHPAYAQTTTSAPTMDMTPLIAVIVGIIPLFIVLSLLDKLGGKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSW5</accession>
    <name>A0A075MSW5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Small ribosomal subunit protein uS8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rps8</name>
        <name evidence="6" type="ORF">NTE_01822</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700576.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSW5"/>
    <dbReference type="STRING" id="1459636.NTE_01822"/>
    <dbReference type="GeneID" id="41597587"/>
    <dbReference type="KEGG" id="nev:NTE_01822"/>
    <dbReference type="eggNOG" id="arCOG04091">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098428_1_1_2"/>
    <dbReference type="OrthoDB" id="5670at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.30:FF:000001">
        <property type="entry name" value="40S ribosomal protein S15a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01302_A">
        <property type="entry name" value="Ribosomal_uS8_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_uS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_uS8_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003115">
        <property type="entry name" value="PRK04034.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S15A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="Ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF83882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="130" mass="14820" checksum="277B50185E34F2D2" modified="2014-10-29" version="1">MPALNVLSNMFTTIYNNETRRKRECIVLPSSKFASEVLRVMQKHRYIGEFEQVDDGRAGKFRIQLLAKINKCGIITPRFSVKKDAYFNWERQFLPAYSMGILLVSTSKGIMSHHEAQAQGLGGVLVGYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSX7</accession>
    <name>A0A075MSX7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Beta-hydroxyacid dehydrogenase, 3-hydroxyisobutyrate dehydrogenase</fullName>
            <ecNumber evidence="5">1.1.1.31</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_02643</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.31" evidence="5"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSX7"/>
    <dbReference type="STRING" id="1459636.NTE_02643"/>
    <dbReference type="KEGG" id="nev:NTE_02643"/>
    <dbReference type="eggNOG" id="arCOG00247">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035117_0_6_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008442">
        <property type="term" value="F:3-hydroxyisobutyrate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051265">
        <property type="entry name" value="HIBADH-related_NP60_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580:SF2">
        <property type="entry name" value="CYTOKINE-LIKE NUCLEAR FACTOR N-PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580">
        <property type="entry name" value="OXIDOREDUCTASE GLYR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="3">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="4">
        <location>
            <begin position="157"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF84686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="292" mass="31169" checksum="2EB982901A676ADB" modified="2014-10-29" version="1">MGSGIAKRLISTGHDVWVYNREKSKANLFSKDAKVAASPLELASNCNLVITVVTNFDAVKQVFFGDKGIAKSSKKNGSHAIIIDASTISPEQSAYCAQELRKVGIEMLGMPVMGGPAAAEAGELVPMVAGSRQAFEKARPVIEKMGKRVFYISEKDGSANAVKLALNLNIALIATAVSEGIMLVKGSGIDPAVFVQVLNTTYFKTGLSEKKGPLMVANDYAPSFHLKNMLKDLELANDTAQVQGITLPTTAHVQQMFRAANNSGYSEMDYTAICAFLAKINGMEGGEGRKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSY7</accession>
    <name>A0A075MSY7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Asparagine synthase (Glutamine-hydrolyzing)</fullName>
            <ecNumber evidence="2">6.3.5.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02164</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.3.5.4" evidence="2"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385382.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSY7"/>
    <dbReference type="STRING" id="1459636.NTE_02164"/>
    <dbReference type="GeneID" id="41597888"/>
    <dbReference type="KEGG" id="nev:NTE_02164"/>
    <dbReference type="eggNOG" id="arCOG00071">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_688115_0_0_2"/>
    <dbReference type="OrthoDB" id="8692at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051786">
        <property type="entry name" value="ASN_synthetase/amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43284:SF1">
        <property type="entry name" value="ASPARAGINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43284">
        <property type="entry name" value="ASPARAGINE SYNTHETASE (GLUTAMINE-HYDROLYZING)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asparagine synthetase" evidence="1">
        <location>
            <begin position="60"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="405" mass="46143" checksum="B768F64A244A6D50" modified="2014-10-29" version="1">MPAAVDYDAIANILTLRYNPRRSPPKRPLAASDFAPSKVDDNVESQILKIIESDLARIKEKRVSVLLSGGVDSVLTLAVLRKFRPDINVSCVSMGFGEDDDEVSAARNIAEAYGCDFCALVLDDVLSGLPRLIKIAREPRWNLYQAYAFEACKEKTIFSGDGGDELFAGYTFRYQKYLSLFSQKKNGWKEKAKLYVSCHERDWVPDQEKVFGPKVRFSWDKIYGLVKRYFSNNGLDPLDQVFLADWNGKLLFDWLPANLAFSKAFEIKIQSLFLSDRMTKFATHLPWRIKYDQDSATGKLPLRAILKGERLRVEPVKKGFSANAVSLWKKRGQEIVKQYVNNSGDSETVRAGVINGDWVQKTTEKLLQAQEEPDIRYVNKMLAVLALEVWWRLFVSKTLKGNEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MT33</accession>
    <name>A0A075MT33_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02219</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700879.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MT33"/>
    <dbReference type="GeneID" id="41597940"/>
    <dbReference type="KEGG" id="nev:NTE_02219"/>
    <dbReference type="HOGENOM" id="CLU_114820_0_0_2"/>
    <dbReference type="OrthoDB" id="5955at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="119" mass="13586" checksum="EF000BEA5175F584" modified="2014-10-29" version="1">MIGLPLYEIARRYKKSREAALPVSGLARMSKRADRSNSKELHTKLLVGRKVKSRDGQFLGHVIIDADKSILVLGHHHYRFDIPKSKIQQIRKDVILSQGYEAVFAYYKPKTTSVHKVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MT83</accession>
    <name>A0A075MT83_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Leader peptidase family protein</fullName>
            <ecNumber evidence="9">3.4.23.52</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NTE_02368</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.23.52" evidence="9"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700999.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MT83"/>
    <dbReference type="STRING" id="1459636.NTE_02368"/>
    <dbReference type="GeneID" id="41598083"/>
    <dbReference type="KEGG" id="nev:NTE_02368"/>
    <dbReference type="eggNOG" id="arCOG02298">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1127120_0_0_2"/>
    <dbReference type="OrthoDB" id="19094at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052218">
        <property type="entry name" value="Preflagellin_Peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009655">
        <property type="entry name" value="Preflagellin_peptidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000045">
        <property type="entry name" value="Prepilin_IV_endopep_pep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36506">
        <property type="entry name" value="PREFLAGELLIN PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36506:SF1">
        <property type="entry name" value="PREFLAGELLIN PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06847">
        <property type="entry name" value="Arc_PepC_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01478">
        <property type="entry name" value="Peptidase_A24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Prepilin type IV endopeptidase peptidase" evidence="7">
        <location>
            <begin position="15"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Preflagellin peptidase C-terminal" evidence="8">
        <location>
            <begin position="211"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF84420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="248" mass="26623" checksum="40E29A8DAF17C82B" modified="2014-10-29" version="1">MMDGTADLALVRICIAFGMFGIAAAMDMRQRYVDDRLWVAFGAVAAVLYFFDFRQMDITIATLSMGLGGAASYLLYRTGLFGGADALALVVFAALLPTYDGRFFLEGISAKGQAHPLSPLMLLSNAAILSFTHLVVNMVKNAQYGARHRSSLFAGMEGETTTRKALAVLLGHRSNGSGFAFLMEKNCGGVRKFDFSLKPAEDTPFESQVGVWVMPGIPFLVYMLAGLAAMVFIGDLAIALLSSFAGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MT97</accession>
    <name>A0A075MT97_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">Methionine aminopeptidase</fullName>
            <shortName evidence="8">MAP</shortName>
            <shortName evidence="8">MetAP</shortName>
            <ecNumber evidence="8 9">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">map</name>
        <name evidence="11" type="ORF">NTE_02290</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="8">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="8 9"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_075054100.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MT97"/>
    <dbReference type="STRING" id="1459636.NTE_02290"/>
    <dbReference type="GeneID" id="41598005"/>
    <dbReference type="GeneID" id="74946045"/>
    <dbReference type="KEGG" id="nev:NTE_02290"/>
    <dbReference type="eggNOG" id="arCOG01001">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015857_7_0_2"/>
    <dbReference type="OrthoDB" id="372008at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01975">
        <property type="entry name" value="MetAP_2_arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050247">
        <property type="entry name" value="Met_Aminopeptidase_Type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028595">
        <property type="entry name" value="MetAP_archaeal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002468">
        <property type="entry name" value="Pept_M24A_MAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018349">
        <property type="entry name" value="Pept_M24A_MAP2_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00501">
        <property type="entry name" value="met_pdase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777:SF2">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01202">
        <property type="entry name" value="MAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 9" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="7 8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8 9" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="10">
        <location>
            <begin position="6"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIF84343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="298" mass="32740" checksum="B3CBAC8AD30EB27E" modified="2014-10-29" version="1">MNAESYLKAGKIAAQVREDARRKYHVGSTLLEVCEKVEAQIRAMGAQPAFPVNASLNEIAAHYTAEPGDQTTVKEGDVLKIDIGVHVDGYIADTAVTVCYDPKFDSLVKAAETALAEAVRMARANTKASDIGRTIETMIGRMGYKPIQNLSGHSLQQYTIHAGKSIPNVWTIGSSFALQPTEAYAIEPFATTKDGMGVVREGKVKNIFGITSRKPSKDKDADSLLEIIWNRYKTLPFALRWLTDAFDDEARLRRTIDVLIKKKNIHAYPILVEGHGRMVAQAEHTLIPNESGSTVITI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTB7</accession>
    <name>A0A075MTB7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Antitoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTB7"/>
    <dbReference type="STRING" id="1459636.NTE_00472"/>
    <dbReference type="KEGG" id="nev:NTE_00472"/>
    <dbReference type="eggNOG" id="arCOG08550">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_170073_1_1_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003847">
        <property type="entry name" value="Put_antitoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02697">
        <property type="entry name" value="VAPB_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="88" mass="9928" checksum="AB2A564A8D67695C" modified="2014-10-29" version="1">MHVSALHMYTYMATITITITDDAYKALKAEKREGESFSDVILRKFQRGNPAAIKAVLLELGPDSELADAIETASRKLRKNFKTRKVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTR1</accession>
    <name>A0A075MTR1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02102</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTR1"/>
    <dbReference type="STRING" id="1459636.NTE_02102"/>
    <dbReference type="KEGG" id="nev:NTE_02102"/>
    <dbReference type="HOGENOM" id="CLU_1933168_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="130" mass="14689" checksum="9A799AEBA2B01AE6" modified="2014-10-29" version="1">MIQFRIENLIVNILDCLDGKKVTRSYLKNAETLLSLITVQDKTECLNILKVLQHIRNSLHSNGVHNNATMSISINGCEFDFRNGQKVQSASWSHIIVALAATFEVLEKILSSSEVKAIPQPIRDHYIEQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTU2</accession>
    <name>A0A075MTU2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03011</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTU2"/>
    <dbReference type="KEGG" id="nev:NTE_03011"/>
    <dbReference type="eggNOG" id="arCOG08800">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1792194_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="128" mass="13752" checksum="7077BE2F41776E6D" modified="2014-10-29" version="1">MFLLPFAPAASGDVTDMTASKPVLKSDSTAITTLAVGDRIILSTDVQSRLNETSTFAAIMEVRGSDGVTEFLNWRFGLIRPDALVSVGLNWTPEKAGTYEARTFVLSGTVNPEVYSPVVSTYFTVGEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MU02</accession>
    <name>A0A075MU02_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PPOX class probable F420-dependent enzyme, Rv0121 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_02627</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701200.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MU02"/>
    <dbReference type="STRING" id="1459636.NTE_02627"/>
    <dbReference type="GeneID" id="41598320"/>
    <dbReference type="KEGG" id="nev:NTE_02627"/>
    <dbReference type="eggNOG" id="arCOG00516">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115786_0_0_2"/>
    <dbReference type="OrthoDB" id="4669at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070967">
        <property type="term" value="F:coenzyme F420 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019967">
        <property type="entry name" value="F420-dep_enz_PPOX_Rv0121"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052019">
        <property type="entry name" value="F420H2_bilvrd_red/Heme_oxyg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03668">
        <property type="entry name" value="Rv0121_F420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35176:SF2">
        <property type="entry name" value="F420H(2)-DEPENDENT REDUCTASE RV1155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35176">
        <property type="entry name" value="HEME OXYGENASE HI_0854-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="PNPOx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine 5'-phosphate oxidase N-terminal" evidence="2">
        <location>
            <begin position="12"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF84670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="152" mass="17478" checksum="9C0D2534168297DD" modified="2014-10-29" version="1">MDDDNATAIIAHDVKELVERARVARLATVDSESKPHLVPIVFVFDDNCFFVPIDEKRKTVKPENLRRLRNIRDNPNVALLIDEYYDDDWTRLAFVMIRGKASIMMAGKTQGGIQLNKVYEKLIAKYPQYQKIGPGETCIVIRPEKVTSWRNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MU09</accession>
    <name>A0A075MU09_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00669</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699657.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MU09"/>
    <dbReference type="GeneID" id="41596528"/>
    <dbReference type="KEGG" id="nev:NTE_00669"/>
    <dbReference type="eggNOG" id="arCOG11147">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1412405_0_0_2"/>
    <dbReference type="OrthoDB" id="382758at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010287">
        <property type="entry name" value="DUF892_YciF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05974">
        <property type="entry name" value="DUF892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="192" mass="21239" checksum="1500B865CC6D53AB" modified="2014-10-29" version="1">MSSPPAINNNNNEKFVQYLNEALAMENAAAERIRSRADETPIEQAKQQLQYHLEQTIQQQNRLKGAISKMGGQPTSSKATLPAFQPMNAPMSVAEQELVRTKEDAIIENAEVTSYKMLMQMAEKAGLKEIVPALQESLQEEVAMVNFISANAPLVLTKLWQELGMYDAAGASFPSYKQQQQKSQDSSVSMAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MU56</accession>
    <name>A0A075MU56_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Mg2+/Co2+ transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NTE_00766</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699737.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MU56"/>
    <dbReference type="STRING" id="1459636.NTE_00766"/>
    <dbReference type="GeneID" id="41596618"/>
    <dbReference type="KEGG" id="nev:NTE_00766"/>
    <dbReference type="eggNOG" id="arCOG02265">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007127_0_0_2"/>
    <dbReference type="OrthoDB" id="28779at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015087">
        <property type="term" value="F:cobalt ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12822">
        <property type="entry name" value="TmCorA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.20">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46494">
        <property type="entry name" value="CORA FAMILY METAL ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46494:SF1">
        <property type="entry name" value="CORA FAMILY METAL ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="209"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIF82844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="317" mass="36416" checksum="CD71C5B4C3B75089" modified="2014-10-29" version="1">MMEAQKRQETITNNGLDWTYIQRPAYVDLAQLGERYPSFHKLNFEDCLSKIQLPKIDRYDDHMFIVLHFPTADKERGFVFSQLSIFIGANFVVTVHQGDLKPLEELFNMCKADEKMRQAIMGRSSGFLLHKIIDTLVDDLLHLLMKVVGNIEDIEDLVFDERISVSRQIALLRREITTLRRIVIHLRRTVLELTKDVQRFSSEDLTPYYKDVQDHVEKVYEALEEAKETVEIYKDTDYVLSTEKTNKILAALTIIFTLSIPATVVSAFYGMNVNIPGGVLTGPWTQLGPYTTLIFTIVLSAAAAGVMLLYFRKEGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUA3</accession>
    <name>A0A075MUA3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Plastocyanin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_03192</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701657.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUA3"/>
    <dbReference type="STRING" id="1459636.NTE_03192"/>
    <dbReference type="GeneID" id="41598848"/>
    <dbReference type="KEGG" id="nev:NTE_03192"/>
    <dbReference type="eggNOG" id="arCOG02926">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084115_4_0_2"/>
    <dbReference type="OrthoDB" id="11836at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000923">
        <property type="entry name" value="BlueCu_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052721">
        <property type="entry name" value="ET_Amicyanin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36507">
        <property type="entry name" value="BLL1555 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36507:SF1">
        <property type="entry name" value="BLL1555 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00127">
        <property type="entry name" value="Copper-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Blue (type 1) copper" evidence="4">
        <location>
            <begin position="48"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="70"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF85221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="138" mass="14007" checksum="E935C3355A19803B" modified="2014-10-29" version="1">MNRKITLAAAGMAAILAAAVLAFTTATSSQTAFAANVNIDIVPGAESKGNQAFSPGSPEVHVGETVTWTNKDSTGHTVTSGSGVPDGKFGVKADGTPDVILPNKTQEFKPTAPGDYAYYCALHPSMVGKLAVEPAGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUB7</accession>
    <name>A0A075MUB7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF3179 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUB7"/>
    <dbReference type="STRING" id="1459636.NTE_02670"/>
    <dbReference type="KEGG" id="nev:NTE_02670"/>
    <dbReference type="eggNOG" id="arCOG09395">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG12828">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037493_1_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021516">
        <property type="entry name" value="DUF3179"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11376">
        <property type="entry name" value="DUF3179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="541" mass="58638" checksum="40635A02A6E0D498" modified="2014-10-29" version="1">MQQRRLGYIERNALTKSLLAGGITMSLYLLVVVLTTPSLPALSAIQASFSANPIVIGGTSTAVAVQTLFASYGKSLFGCNLEKRSRLGTGSGSAVGSFFSFFSLVPLGCCGSWLLLLSFLPSVLGTAASAFLIDYSKPLSYVATASVLGLTVLNGARLHRRMSRMAPRPPSVSIGKPLAILIGSIVLAVVIIASAAAATYQQQQPSSNTTSATGDRPAGPFVVVPPDKIVNGGPPRDGIPSIDNPKFTSANGAGLGDSDLVLGLEINGDIRAYPLRIMVWHEIVNDNVGGMPVAVTYCPLCFTNQVFKRAVVDDGNNNTVVEFGTSGKLYNSNLVMYDRTSESLWSQALGQGIAGKYAGVKLERVPFDLAYWKDWKELHPQSKVLSQDTGYGRPYGSDPYGDYYTSPDILFPVSHRDDRLGPKEIVIGLEENSGTYKAYKLQDVEDRHVINDQVGARPIALFSVYPFGVRLFDRALDDGAVLDFQYPDGKIMDKQTSSVWDFNGRAIEGPLKGKQLSRLPFDEGFWFEWVAFHPETELYSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUF1</accession>
    <name>A0A075MUF1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">P-type Cu(+) transporter</fullName>
            <ecNumber evidence="3">7.2.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">NTE_02696</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.8" evidence="3"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701256.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUF1"/>
    <dbReference type="STRING" id="1459636.NTE_02696"/>
    <dbReference type="GeneID" id="41598385"/>
    <dbReference type="KEGG" id="nev:NTE_02696"/>
    <dbReference type="eggNOG" id="arCOG01576">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG04507">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001771_0_3_2"/>
    <dbReference type="OrthoDB" id="8588at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043682">
        <property type="term" value="F:P-type divalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140581">
        <property type="term" value="F:P-type monovalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055070">
        <property type="term" value="P:copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02094">
        <property type="entry name" value="P-type_ATPase_Cu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000144">
        <property type="entry name" value="copper-transporting ATPase 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000002">
        <property type="entry name" value="Copper-transporting ATPase 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007029">
        <property type="entry name" value="YHS_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01511">
        <property type="entry name" value="ATPase-IB1_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520">
        <property type="entry name" value="ATP7, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520:SF8">
        <property type="entry name" value="P-TYPE CU(+) TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04945">
        <property type="entry name" value="YHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00943">
        <property type="entry name" value="CUATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-0187">Copper transport</keyword>
    <keyword evidence="18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="14 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="640"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="669"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="domain" description="YHS" evidence="17">
        <location>
            <begin position="3"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="16">
        <location>
            <begin position="176"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="AIF84738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="729" mass="77750" checksum="177C0AF5E28A56AD" modified="2014-10-29" version="1">MAKDPVCGMFVEEKPDAIRHTADGREYFFCSTQCLNEFTAPEKELRKLKIVTGVSIALTIPITILTYLMLLPKEVNSYVLLALAAPVQFWAGWRFYKGTWDAIKARASNMDTLIAVGTTAAFLYSAVVTVAPGLFPFEGVYFETAAIIITLILIGRLLETRTKEKASNAVRKLLDLQPRMARVIRDGGREEEVPVEQVQEGDLFLVRPGERIPTDGTVAEGSSSVDESAVTGESIPVDKSAGSEVIGATINKSGLLKARATKVGQDTVLSQIIALVQEARTGKAQMQKMADQVAKYFVPAVIAVAIASALAWYFVGGIGLTFSLLAFVSVIIIACPCALGIATPAALMMGAGKGAENGILFKGEEYLEMARKVRTAVFDKTGTLTKGQPEATDVIALSEKMGGQQELLRLAAIAESGSEHPLGQAIVRKAKEQGLVIASPESFEAVSGHGLKAGYAGHSIMIGNRKMMADNGIAVPDKVNATMSRLETEGKTATLVSVDGSLAGIVAMADTVKEHAQEAIDSLKQMGIRVVMLTGDNERTARAIASSLGIDRVIAQVLPQQKERVITELKSEGRGAVAMVGDGINDAPALARADLGIAIGSGTDVAKETGGIILIKNDLRDVVTAFELGRKTVSKIKQNLFWAFAYNTGLIPIAAGALVPAFGAQMYEWLPLLAGGAMAMSSVSVVGNSLLLGRYRPRFATAEGKPEKERIYGEKEPKQVYYYNNAEAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUF5</accession>
    <name>A0A075MUF5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Large ribosomal subunit protein uL15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpl15</name>
        <name evidence="7" type="ORF">NTE_02795</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701343.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUF5"/>
    <dbReference type="STRING" id="1459636.NTE_02795"/>
    <dbReference type="GeneID" id="41598483"/>
    <dbReference type="KEGG" id="nev:NTE_02795"/>
    <dbReference type="eggNOG" id="arCOG00779">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109163_0_0_2"/>
    <dbReference type="OrthoDB" id="9418at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.990.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_uL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027386">
        <property type="entry name" value="Rbsml_uL15_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_uL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="6">
        <location>
            <begin position="72"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF84835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="146" mass="15959" checksum="232CB06CEF20E52A" modified="2014-10-29" version="1">MATRFRKSRRQRGSRYCGWGQIGQHRQAGSRGGIGGAGKHKHFFIRTVIEEPNHFGHDPFNSFNRNVVNTWLNVRDLDAVFAKHGKADEKGKVVLDLTALGYDKLLGGGKISGAYTIKVAKVSEGARAKITAAGGEVIADEQHDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUH5</accession>
    <name>A0A075MUH5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701743.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUH5"/>
    <dbReference type="STRING" id="1459636.NTE_03287"/>
    <dbReference type="GeneID" id="41598941"/>
    <dbReference type="KEGG" id="nev:NTE_03287"/>
    <dbReference type="eggNOG" id="arCOG14338">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2629858_0_0_2"/>
    <dbReference type="OrthoDB" id="11207at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="92" mass="10293" checksum="E5D1ADF34D4278FC" modified="2014-10-29" version="1">MAFSLKHVAMQLCTCTWIEIMTGAGITLYLLLYMQNYTLAAVTVAAFGPLIGFHFAIDRIKPGKDGWKKTENNRIVKIRSLSGRQSYPLLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUI3</accession>
    <name>A0A075MUI3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00898</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUI3"/>
    <dbReference type="STRING" id="1459636.NTE_00898"/>
    <dbReference type="KEGG" id="nev:NTE_00898"/>
    <dbReference type="eggNOG" id="arCOG03106">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1954736_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="132" mass="15093" checksum="6B18AB378F0A6500" modified="2014-10-29" version="1">MYTVMPKSNVKGSDGREGIVYRFFKLIEDKDIDGLLDLFDCDATVYEPFSKTQGLHGRSLIEPFLKVAMMANNNMRHKIKIPDSGKSHLDGQLTALVTFELGDRAKARFIFDLEPDEQKAWKIKTLHINFLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUK5</accession>
    <name>A0A075MUK5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">NTE_02757</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the KEOPS complex that consists of Kae1, Bud32, Cgi121 and Pcc1; the whole complex dimerizes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. BUD32 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUK5"/>
    <dbReference type="STRING" id="1459636.NTE_02757"/>
    <dbReference type="KEGG" id="nev:NTE_02757"/>
    <dbReference type="eggNOG" id="arCOG01185">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063953_2_0_2"/>
    <dbReference type="OrthoDB" id="31344at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000201">
        <property type="entry name" value="TP53-regulating kinase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022495">
        <property type="entry name" value="Bud32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018934">
        <property type="entry name" value="RIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03724">
        <property type="entry name" value="arch_bud32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011462">
        <property type="entry name" value="PRK14879.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011463">
        <property type="entry name" value="PRK14879.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209:SF0">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT TP53RK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209">
        <property type="entry name" value="NON-SPECIFIC SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01163">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="1"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00065170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIF84798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="205" mass="23026" checksum="E50FBA1BFD6F9890" modified="2014-10-29" version="1">MQQLLKKGAEADIYYLADWHGKQAIAKVREPKPYRHSALDSSIRRQRTVHEAGFMSAAKSAGVRTPFVYFVDPERAEIIMERVDGTPARDALTAKLCQEMGRYAALLHAAGIVHGDLTTSNFIVDNNNRLVLLDFGLSYYSERTEDMAVDVRLIKEVFTSAHISVRGAFSSFVKGYESVAGKKKTTKILENVREIEQRGRYARVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUL3</accession>
    <name>A0A075MUL3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00923</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUL3"/>
    <dbReference type="KEGG" id="nev:NTE_00923"/>
    <dbReference type="HOGENOM" id="CLU_1987512_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="125" mass="14693" checksum="02A58B289A8C9EBE" modified="2014-10-29" version="1">MLTWLSDTCRTIPSDYANILRFCTLTGLRLDEAFQSIHLIQNDPAKYLNKGRLTLEHFQYPSIFVRRTKKAFISLVTEEILKLAKDSPDCGYNAFRLMLKRRDFIEHGLLSQDILHLSSHEWHRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUP5</accession>
    <name>A0A075MUP5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamyl-tRNA(Gln) amidotransferase subunit A</fullName>
            <shortName evidence="7">Glu-ADT subunit A</shortName>
            <ecNumber evidence="7">6.3.5.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gatA</name>
        <name evidence="9" type="ORF">NTE_02818</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-glutamyl-tRNA(Gln) + L-glutamine + ATP + H2O = L-glutaminyl-tRNA(Gln) + L-glutamate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the amidase family. GatA subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.7" evidence="7"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701361.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUP5"/>
    <dbReference type="STRING" id="1459636.NTE_02818"/>
    <dbReference type="GeneID" id="41598503"/>
    <dbReference type="KEGG" id="nev:NTE_02818"/>
    <dbReference type="eggNOG" id="arCOG01717">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009600_0_3_2"/>
    <dbReference type="OrthoDB" id="7931at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00120">
        <property type="entry name" value="GatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004412">
        <property type="entry name" value="GatA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00132">
        <property type="entry name" value="gatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895:SF7">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT A, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 7 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Amidase" evidence="8">
        <location>
            <begin position="24"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="7">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF84858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="478" mass="51583" checksum="A35DB1A767534EA9" modified="2014-10-29" version="1">MLYRLDASQVANGVKNREFSAEEYIHQILERIEVVEPKVNALVTVNSKGAVEQARALDKKIRDGEAAGPLAGVAVSIKDNISTKGIRTTCASKMLDGYVPPYDATVVKRLQDAGAIVIGKANLDEFAMGSTTEFSRNGPTRNPWDISRVPGGSSGGSAASVAALECAISLGSDTGGSVRCPASFCSVVGLKPTYGLVSRYGLISYANSLEQVGPVGRTVADVAATLAAMAGQDDNDHTTAPGKPSYLVSKMPLRVGLVKEFVEDADPKVSKIVYSAYDTLEKEGCRCAEASMPSVQYALASYYTIAMAEASSNLARYDNVRYGFDMSPDGYEWNSYFAKSRSNFGEEVKRRIITGSYVLSSGYYGKYYLKAQQVRSLLRRELKSLFTQFDVLIGPTMPILPFPIGEKVDDPLKMYLVDVDTVVANLAGIPAISVPAGFSNNNLPIGLQFMADEFSEQTMFDAAYTFESVAKVQRSPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUV0</accession>
    <name>A0A075MUV0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hemerythrin HHE cation binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701851.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUV0"/>
    <dbReference type="STRING" id="1459636.NTE_03413"/>
    <dbReference type="GeneID" id="41599056"/>
    <dbReference type="KEGG" id="nev:NTE_03413"/>
    <dbReference type="HOGENOM" id="CLU_1811358_0_0_2"/>
    <dbReference type="OrthoDB" id="11540at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.520">
        <property type="entry name" value="nmb1532 protein domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin-like" evidence="1">
        <location>
            <begin position="14"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="142" mass="16658" checksum="9909C2DAD9E76B80" modified="2014-10-29" version="1">MSYRINFDEPIPDLIERLKREHRQLESKLAAVESADTVNEQSIRILEELSEPIIRHAVEEEARVLRVIMHEAKEQSRESIKIAQEHNWIADFIKKTIPKLSSMPQQQAKQEVTQFILDLRQHFSEEEEIMFPLALKASSVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUW1</accession>
    <name>A0A075MUW1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701469.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUW1"/>
    <dbReference type="STRING" id="1459636.NTE_02960"/>
    <dbReference type="GeneID" id="41598631"/>
    <dbReference type="KEGG" id="nev:NTE_02960"/>
    <dbReference type="HOGENOM" id="CLU_2519889_0_0_2"/>
    <dbReference type="OrthoDB" id="372604at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="84" mass="9379" checksum="139EEF9EFA9B2B35" modified="2014-10-29" version="1">MAVKRIPLSRKDVKLFHEANVFDKVYNGGYPTAAAFFIGYVTGRNKVAPLSIVKAESVSIEYEKDGSRGYLKISGKGKARQKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUY7</accession>
    <name>A0A075MUY7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_03000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701505.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUY7"/>
    <dbReference type="STRING" id="1459636.NTE_03000"/>
    <dbReference type="GeneID" id="41598670"/>
    <dbReference type="KEGG" id="nev:NTE_03000"/>
    <dbReference type="HOGENOM" id="CLU_2091380_0_0_2"/>
    <dbReference type="OrthoDB" id="384993at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF85035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="128" mass="13083" checksum="D0E465F52D42E2BE" modified="2014-10-29" version="1">MVKSCSNTISSHDVAMVSGKLGIGAILVVLGIGGMAYAMPIESNSMVLDGNSPVIYQKAPHPPLPSSMVPYVGIVAASAASLALGIAFLAVGQTEVYKPTAPVYKAKEGKQENKQASQSSPKHTADAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUZ0</accession>
    <name>A0A075MUZ0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03448</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUZ0"/>
    <dbReference type="KEGG" id="nev:NTE_03448"/>
    <dbReference type="HOGENOM" id="CLU_3020786_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="55" mass="6142" checksum="9C986F44DEF0F3E1" modified="2014-10-29" version="1">MGMGSLMQLVSKYSMKQQNIPFLLFEYAVIPSYLLATILATLSQQDNSISQSGHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MV21</accession>
    <name>A0A075MV21_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NTE_02973</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701482.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MV21"/>
    <dbReference type="STRING" id="1459636.NTE_02973"/>
    <dbReference type="GeneID" id="41598644"/>
    <dbReference type="KEGG" id="nev:NTE_02973"/>
    <dbReference type="eggNOG" id="ENOG502N5MX">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079292_1_1_2"/>
    <dbReference type="OrthoDB" id="7631at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003416">
        <property type="entry name" value="MgtC/SapB/SrpB/YhiD_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049177">
        <property type="entry name" value="MgtC_SapB_SrpB_YhiD_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33778:SF1">
        <property type="entry name" value="MAGNESIUM TRANSPORTER YHID-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33778">
        <property type="entry name" value="PROTEIN MGTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02308">
        <property type="entry name" value="MgtC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01837">
        <property type="entry name" value="MGTCSAPBPROT"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="MgtC/SapB/SrpB/YhiD N-terminal" evidence="7">
        <location>
            <begin position="19"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF85008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="147" mass="15325" checksum="CA84CFD3907B093C" modified="2014-10-29" version="1">MVFEGIPAGYEVRFLVGIGISLAAGFAIGAERESRNKAAGISTHCLVIGGSMIFTLLSSLVDPNSSSRIAAQIISGIGFLGAGLILKSELDGKITNLTTAAAVWFAASIGMAIGYEYYFLAIVATAFAVGVPRIPHISRMIKKGEET</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MV29</accession>
    <name>A0A075MV29_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03483</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MV29"/>
    <dbReference type="KEGG" id="nev:NTE_03483"/>
    <dbReference type="HOGENOM" id="CLU_3322772_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="38" mass="4355" checksum="68C613466104011A" modified="2014-10-29" version="1">MNANEEGADSIEEYLYDIFSTSLFLFPLNLNKPLNPHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MV63</accession>
    <name>A0A075MV63_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">tRNA(1-methyladenosine) methyltransferase-like methyltransferase</fullName>
            <ecNumber evidence="8">2.1.1.219</ecNumber>
            <ecNumber evidence="8">2.1.1.220</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NTE_03013</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.219" evidence="8"/>
    <dbReference type="EC" id="2.1.1.220" evidence="8"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987028.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MV63"/>
    <dbReference type="STRING" id="1459636.NTE_03013"/>
    <dbReference type="GeneID" id="41598683"/>
    <dbReference type="KEGG" id="nev:NTE_03013"/>
    <dbReference type="eggNOG" id="arCOG00978">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025402_0_1_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043827">
        <property type="term" value="F:tRNA (adenine(57)-N1)/(adenine(58)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160107">
        <property type="term" value="F:tRNA (adenine(58)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049470">
        <property type="entry name" value="TRM61_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014816">
        <property type="entry name" value="tRNA_MeTrfase_Gcd14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133:SF2">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE CATALYTIC SUBUNIT TRMT61A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08704">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017269">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51620">
        <property type="entry name" value="SAM_TRM61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61 C-terminal" evidence="7">
        <location>
            <begin position="57"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="260"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR017269-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF85048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="273" mass="30337" checksum="0AAE54F6C730EF18" modified="2014-10-29" version="1">MKIQEGSYVLLFHTSRKKWLTKVTPDKKIHTHLGIIDVGATIGMEYGSVIRTTEGKVVFLIEPTTHDFIMKSERRTQIVYPKDLGFIAARTGMKNGSKILEIGTGSAAAATFFASIVKPEGHIYSFDVNPDFMEIAKRNLEKAGMADYVTLNHHDPHEGVDVREADIAIVDLGDPWTVLDQVHDALKGSGAFVAICPTMNQIEKTATELKKSGYADIESIELLIRTMEAREGMTRPSMRMIGHTTYLVFARKVQKKAEAPSEEPEEEGEEGIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MV97</accession>
    <name>A0A075MV97_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03153</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MV97"/>
    <dbReference type="STRING" id="1459636.NTE_03153"/>
    <dbReference type="KEGG" id="nev:NTE_03153"/>
    <dbReference type="HOGENOM" id="CLU_182706_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="97" mass="10922" checksum="D19D8F3365A35827" modified="2014-10-29" version="1">MVGACTDNRCPLFMFAHMEGEKLRCNICNEIVEMAEVGQHVTGRNHAVKKKVAEFHEMNAQVGNNSSRRNYDGDDTSVVNAWIRGLYVRDYLSLGTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVA0</accession>
    <name>A0A075MVA0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LPXTG cell wall anchor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701128.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVA0"/>
    <dbReference type="GeneID" id="41598234"/>
    <dbReference type="KEGG" id="nev:NTE_02535"/>
    <dbReference type="HOGENOM" id="CLU_1607072_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01167">
        <property type="entry name" value="LPXTG_anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="165" mass="17210" checksum="A5C2853C033C5998" modified="2014-10-29" version="1">MTASISFSGSGFDFDINMYGFTPGELVTIVFTNVNNSNDMYSIDTYVGYNPIHVLQQHFPAEAEGNYHVTAVGSTGTKAENTLTIGYPTVQGILPNTEVPLENITNQGGETVPIFGQLESIGGAAVPSAIPTQTSQNNSIPLVLAGGALLGGLLLISGGKKKVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVA5</accession>
    <name>A0A075MVA5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0201 protein NTE_03058</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03058</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0201 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701556.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVA5"/>
    <dbReference type="STRING" id="1459636.NTE_03058"/>
    <dbReference type="GeneID" id="41598726"/>
    <dbReference type="KEGG" id="nev:NTE_03058"/>
    <dbReference type="eggNOG" id="arCOG01043">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134829_1_0_2"/>
    <dbReference type="OrthoDB" id="7819at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01112">
        <property type="entry name" value="UPF0201"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002739">
        <property type="entry name" value="PAB1135-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_uL5_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39652">
        <property type="entry name" value="UPF0201 PROTEIN TK1335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39652:SF1">
        <property type="entry name" value="UPF0201 PROTEIN TK1335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01877">
        <property type="entry name" value="RNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="RL5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="136" mass="14894" checksum="C0B8A91409BE9F7C" modified="2014-10-29" version="1">MRKPRVSSPIEVKVEAVVNPSEDPQKVIGAIENVIERCSPEFRYGSRVIGRAAGSEPLSTIYEQVRSRSAMGVLRRMLLDNRAGTSTWFLLNKQAASAGIAAVIEDEQESPLGPIRVTINCEELDALTDWLVPESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVE5</accession>
    <name>A0A075MVE5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Small ribosomal subunit protein uS2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rps2</name>
        <name evidence="7" type="ORF">NTE_02594</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVE5"/>
    <dbReference type="STRING" id="1459636.NTE_02594"/>
    <dbReference type="KEGG" id="nev:NTE_02594"/>
    <dbReference type="eggNOG" id="arCOG04245">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058171_3_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000030">
        <property type="entry name" value="30S ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00291_A">
        <property type="entry name" value="Ribosomal_uS2_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_uS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023454">
        <property type="entry name" value="Ribosomal_uS2_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005707">
        <property type="entry name" value="Ribosomal_uS2_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_uS2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01012">
        <property type="entry name" value="uS2_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11489">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN SA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="Ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF84637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="245" mass="26734" checksum="11B95F77672ED39D" modified="2014-10-29" version="1">MSNNPEDDSSPKDEIRAEDETTTGTDDNSSTTTPVESPEGQDSIDTDNLEKMILSTGIRVGTPVKTKYMSPFIVRANPEGLYILDISKTLARIDVAAKFIGRSDISKVAVTSAREYGKTPVEKFCELTGATPILGRFMPGTFTNPSLPDYMEPEIVVVTDPQADQQAVIEATRAGKPVIAVSNSDNVTSKVDLVIPANNRGRKALATVYWLLAREVMKKQGKIKSDSEMKVSIDDFETKLVEEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVK2</accession>
    <name>A0A075MVK2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03231</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701692.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVK2"/>
    <dbReference type="STRING" id="1459636.NTE_03231"/>
    <dbReference type="GeneID" id="41598886"/>
    <dbReference type="KEGG" id="nev:NTE_03231"/>
    <dbReference type="eggNOG" id="arCOG08782">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_202921_0_0_2"/>
    <dbReference type="OrthoDB" id="5631at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="73" mass="8552" checksum="1E022FFE7450DD45" modified="2014-10-29" version="1">MVRKFEEWWNSVPADLRQKARAGDEGNKPLLNQVNYVLLHLHLAGKHDQKPSHEELKEWLHSGQVDVLRMAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVM0</accession>
    <name>A0A075MVM0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700121.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVM0"/>
    <dbReference type="GeneID" id="41597070"/>
    <dbReference type="KEGG" id="nev:NTE_01265"/>
    <dbReference type="HOGENOM" id="CLU_2165140_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="110" mass="12386" checksum="67F13641C0FE0070" modified="2014-10-29" version="1">MGNCQDELAKLWIFLNLILYDNEVLEAKLRYVTNHLSAKQRQSIAAELDDAITSDKDKANQILVKRTEQIMASLQLSPANLMSLQNELLEEMKRVCNGDTTTATTKFALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVS2</accession>
    <name>A0A075MVS2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Exosome complex component Csl4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">csl4</name>
        <name evidence="3" type="ORF">NTE_03209</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. Interacts with DnaG.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSL4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701673.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVS2"/>
    <dbReference type="STRING" id="1459636.NTE_03209"/>
    <dbReference type="GeneID" id="41598866"/>
    <dbReference type="KEGG" id="nev:NTE_03209"/>
    <dbReference type="eggNOG" id="arCOG00676">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067135_1_1_2"/>
    <dbReference type="OrthoDB" id="6768at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000178">
        <property type="term" value="C:exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00975">
        <property type="entry name" value="Exosome_Csl4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039771">
        <property type="entry name" value="Csl4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030850">
        <property type="entry name" value="Exosome_Csl4_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF034126">
        <property type="entry name" value="PRK09521.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12686">
        <property type="entry name" value="3'-5' EXORIBONUCLEASE CSL4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12686:SF8">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT CSL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110324">
        <property type="entry name" value="Ribosomal L27 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0271">Exosome</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF85238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="201" mass="22197" checksum="771A0DBE37F12019" modified="2014-10-29" version="1">MSKENNNKVMIMLPGEQVASIEEFEGGKNTYLTQDGTIRSAAIGTKAMDLKRRVIKIEPKNAPMLPKIGDILVGYVEMIFASMISVKVLYINGVESTSGFSAIASMRVGGGGRDRRERPIFRTGDIIRGRVMSLLNSTVHMTIAEREFGVLYTTCFMCGGDTVKVNDTVKCIECGAWEPRKLTNDYGKETLRQIFRAGGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVV6</accession>
    <name>A0A075MVV6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01371</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVV6"/>
    <dbReference type="KEGG" id="nev:NTE_01371"/>
    <dbReference type="HOGENOM" id="CLU_1729188_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11578">
        <property type="entry name" value="DUF3237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="161" mass="17273" checksum="DA6F6344BB364DBE" modified="2014-10-29" version="1">MGHKVIDKKPISKQMESSELVYEVALHITGVVEYGANLQAITTGKAAPPPEGARFDVSLEGTVDGPRFKGSWHGVDYLNIRADGLSELHIHGQFDMADGGKVSMFADGIGTIDAKGIVHLRENVTLKSNYSAHAWVNSIVVWGVGTVNLATGEVRVKGYKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MW30</accession>
    <name>A0A075MW30_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03432</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MW30"/>
    <dbReference type="KEGG" id="nev:NTE_03432"/>
    <dbReference type="HOGENOM" id="CLU_2490281_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="86" mass="9933" checksum="125E8025C994C2B7" modified="2014-10-29" version="1">MLAGINSSQCLRKKAYCLEDDRNLVRIHFGLVLASSEVRLTLGKKYDISITRGVNIEWQAEHMVMLTCHRLEKDVNIRRFGLTKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MW78</accession>
    <name>A0A075MW78_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_02859</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701393.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MW78"/>
    <dbReference type="STRING" id="1459636.NTE_02859"/>
    <dbReference type="GeneID" id="41598541"/>
    <dbReference type="KEGG" id="nev:NTE_02859"/>
    <dbReference type="eggNOG" id="arCOG01792">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063529_0_0_2"/>
    <dbReference type="OrthoDB" id="8915at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053173">
        <property type="entry name" value="SAM-binding_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048711">
        <property type="entry name" value="WHD_Rv2258c"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45128:SF2">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45128">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21320">
        <property type="entry name" value="WHD_Rv2258c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S-adenosylmethionine-dependent methyltransferase Rv2258c-like winged HTH" evidence="2">
        <location>
            <begin position="25"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="171"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF84897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="351" mass="38145" checksum="F83E91D465B77368" modified="2014-10-29" version="1">MVDEAKLNEFIGKVVSDMGGGAGVLLAFVGDRLGLYRAMAGAGSITADALAQKTGTNPRMIREWLASQAAGGYVSYDAKTGEYMLPEEQAMALAQEGGPAFMQGGFQILVSLFKDEQKIIEAVRTGRGLSWGDHDKCLFEGTERFFRPAYNANLIRNWIPALDGVEAKLVKGAKMADVGCGHGASTILLAKAYPNSKFYGFDYHEPSIEWAKKQAEKEGVADRVTFQVAKSTDFAGDDYDVVAFFDCLHDMADPYGAAAHTYRALKKKDGTMFIVEPYAEDRLEDNLNPLGRLFYSASTTVCVPASLAQGGPGLGAQAGEKRIREVVEKGGFTRFRRAMKSPVNLVYEARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MW79</accession>
    <name>A0A075MW79_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01481</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700296.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MW79"/>
    <dbReference type="STRING" id="1459636.NTE_01481"/>
    <dbReference type="GeneID" id="41597273"/>
    <dbReference type="KEGG" id="nev:NTE_01481"/>
    <dbReference type="HOGENOM" id="CLU_2930321_0_0_2"/>
    <dbReference type="OrthoDB" id="8623at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="60" mass="6854" checksum="1C16750DFF1EB518" modified="2014-10-29" version="1">MVETKKLLLEAEILIDVPTDIVEDEERLDDVTKGLSKALTKGLYDQGIDFQVNRMSFKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MW96</accession>
    <name>A0A075MW96_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NTE_01496</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385217.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MW96"/>
    <dbReference type="STRING" id="1459636.NTE_01496"/>
    <dbReference type="GeneID" id="41597285"/>
    <dbReference type="KEGG" id="nev:NTE_01496"/>
    <dbReference type="eggNOG" id="arCOG02358">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG03644">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="8127at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054513">
        <property type="entry name" value="Dret_0059-like_sensor"/>
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        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050736">
        <property type="entry name" value="Sensor_HK_Regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43711:SF1">
        <property type="entry name" value="HISTIDINE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43711">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HisKA"/>
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    <dbReference type="Pfam" id="PF22309">
        <property type="entry name" value="HK-GC-Chemotax_sensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
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        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
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    </dbReference>
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        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="374"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF83559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="610" mass="67480" checksum="A66ED0134CDFDF69" modified="2014-10-29" version="1">MNFIKRKLVEYSLGPKARTTGVISVIFVIVLSVGLFIYTLNVTESSIKASLFDQQKERQVEAATKISEHIGSDLNLVLSTLDGLANSYYLQEGDLHSQDARSLVEEKYAQLDPTVKGLFVLDKNDIVTISLAPPSSETFLSADFSLRDWVIETRANHQPVFSNGFERQGMYRVFISYPIINKSTHEYIGIIGVSIPTVSFFAHYANVEDINSQFLIAYDHDGVMLANGASASLVGKNFFGKEAQASINHNPVLNNLTKSLLQGHSGYGVYDYGDGERITTQYPVFVQGKPTYFIQLVTPTTQIYSEVNDALFAERTKLGLLLTGTISAITILVILLIKWNNILNKEVKIRTRELGEANERLQANIKTQREFLNIAAHELRTPIQPILGLAEVLYDTDNSGSSNSNDNNSSSTIVASSQEKHLLEIIIRNARRLQGLSEDLLDVSRIESQSLKLNKVRFNLADVVARTVEDLGNSFASGDKKVELVAVPYEGREGDVIVNADKERIVQVISNLLHNALEFTREGTIWTSIQRKDGQTIVTVRDTGDGIDAEVFPRLFTKFVTKSKKGTGLGLFISKGIIEAHGGKMWAENNANGKGAAFFFSIPDDDNNTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWB0</accession>
    <name>A0A075MWB0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_03507</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWB0"/>
    <dbReference type="KEGG" id="nev:NTE_03507"/>
    <dbReference type="eggNOG" id="arCOG03748">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120314_0_0_2"/>
    <dbReference type="OrthoDB" id="11852at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="181"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF85535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="195" mass="21483" checksum="F9E584C3769FD157" modified="2014-10-29" version="1">MSTNSSIRKTDSLIHFMVLDAISKDIRDVARIAEATKFDKADVELIVNDLLAHQLVSLSERRKLFRRTSTQTRITKIGSRLLYKKRHELDLGAKALRACYYNSDRKTMESLMDDNRVWIPTMIFSGIMSAALFASMMSFMGMAMNPTEAAMVEDSIAGSEQKTGDNNNIADAQTTDGESQTASADTGADDIAATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWD7</accession>
    <name>A0A075MWD7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2-isopropylmalate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01531</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700338.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWD7"/>
    <dbReference type="STRING" id="1459636.NTE_01531"/>
    <dbReference type="GeneID" id="41597318"/>
    <dbReference type="KEGG" id="nev:NTE_01531"/>
    <dbReference type="eggNOG" id="arCOG03003">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1574906_0_0_2"/>
    <dbReference type="OrthoDB" id="10584at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="169" mass="19148" checksum="5B1D8CBE65C09B72" modified="2014-10-29" version="1">MIRAPEITALREEEEQRSARKYIFKPSIRPASELKGHKDGQGTRYVFVDSKLVPAANFYTIVRVVKNVKEDKISHVDIHKHDCDSAFIFLGDSPNFEGLTCEVMLDDETFTVQSPATVYIPAGVMHTYRFISGSGMYWNIVLSGDYNSRTMLQQQSIPFAAGRKEIIQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWD8</accession>
    <name>A0A075MWD8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein uS11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rps11</name>
        <name evidence="9" type="ORF">NTE_02936</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Located on the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_075054699.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWD8"/>
    <dbReference type="STRING" id="1459636.NTE_02936"/>
    <dbReference type="GeneID" id="41598614"/>
    <dbReference type="KEGG" id="nev:NTE_02936"/>
    <dbReference type="eggNOG" id="arCOG04240">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072439_6_0_2"/>
    <dbReference type="OrthoDB" id="12054at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022626">
        <property type="term" value="C:cytosolic ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044391">
        <property type="term" value="C:ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.80:FF:000018">
        <property type="entry name" value="40S ribosomal protein S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="entry name" value="Ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_uS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_uS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019961">
        <property type="entry name" value="Ribosomal_uS11_archaeal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018102">
        <property type="entry name" value="Ribosomal_uS11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_uS11_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03628">
        <property type="entry name" value="arch_S11P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007176">
        <property type="entry name" value="PRK09607.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S14/30S RIBOSOMAL PROTEIN S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002131">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00054">
        <property type="entry name" value="RIBOSOMAL_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF84972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="135" mass="14345" checksum="0A05BB1CDC3EC884" modified="2014-10-29" version="1">MSEQDEVTQTRWGVAHIFSSYNNTLVHITDLSGSETISFSSGGRHVTADRYESSPYAAMKSAVAAAEVAKGKGINALHIRVRAVGGVGPRIPGPGAQAAIRALARAGFRIGRIDDVTPIPHDTTRKPGGRRGRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWE8</accession>
    <name>A0A075MWE8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWE8"/>
    <dbReference type="STRING" id="1459636.NTE_03430"/>
    <dbReference type="KEGG" id="nev:NTE_03430"/>
    <dbReference type="HOGENOM" id="CLU_2419877_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="91" mass="10079" checksum="327B9F28266AF603" modified="2014-10-29" version="1">MRSCRIISISRFKSGLSISRTNFFMYMKVKETTAQNYCFGIAMVLIALAIIFVSLSASSHYELATVVAYLTIPTAIVLGAVGMVIKYNQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWK4</accession>
    <name>A0A075MWK4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWK4"/>
    <dbReference type="KEGG" id="nev:NTE_03480"/>
    <dbReference type="HOGENOM" id="CLU_2874909_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="63" mass="7082" checksum="1E234BEB1D499031" modified="2014-10-29" version="1">MDHDFIMLAVILAAIGSAGIYTGVISHPIMYINSVVIFGGLGYMVWQLDRDQRVTKKDARWNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWP2</accession>
    <name>A0A075MWP2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01622</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700411.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWP2"/>
    <dbReference type="GeneID" id="41597401"/>
    <dbReference type="KEGG" id="nev:NTE_01622"/>
    <dbReference type="HOGENOM" id="CLU_2230257_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="105" mass="11109" checksum="5FE3530CEF56B534" modified="2014-10-29" version="1">MKRVKRSTLVVIGIVGLAGLVPVLIVNQIQGQPLPPVINFALSPIPFAFLAVGALIVRQGFTMWEHVGEPNYEPDYVLGAMILIVGMVFTGAGSFGMLLIFGGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWP9</accession>
    <name>A0A075MWP9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Zn-dependent hydrolase of beta-lactamase fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03037</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701537.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWP9"/>
    <dbReference type="STRING" id="1459636.NTE_03037"/>
    <dbReference type="GeneID" id="41598706"/>
    <dbReference type="KEGG" id="nev:NTE_03037"/>
    <dbReference type="eggNOG" id="arCOG00497">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070010_0_1_2"/>
    <dbReference type="OrthoDB" id="28313at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050114">
        <property type="entry name" value="UPF0173_UPF0282_UlaG_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43546:SF8">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43546">
        <property type="entry name" value="UPF0173 METAL-DEPENDENT HYDROLASE MJ1163-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13483">
        <property type="entry name" value="Lactamase_B_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="217" mass="23962" checksum="0BFD18A3C01AC76C" modified="2014-10-29" version="1">MLDYKGIKFHWLGHDGFRIVAGGKTIYVDPYEMTKAQHGKNDADIVMITHNHYDHLSMDDLKQVVGKKTELVAAKECAEQLKPLGLAVKAVAPGDRVTVQGVQVEAVAAYNTNKKFHPKGDKKVGYVITLNGMRVYHSGDTDDIQEMSQVQPDIALVPVSGTYVMTADEAAKAVNEKIKPKMLAIPMHYASIVGSEKDAARFKELVRACPVEILERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWR7</accession>
    <name>A0A075MWR7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative Fe-S oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NTE_01648</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700432.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWR7"/>
    <dbReference type="STRING" id="1459636.NTE_01648"/>
    <dbReference type="GeneID" id="41597423"/>
    <dbReference type="KEGG" id="nev:NTE_01648"/>
    <dbReference type="eggNOG" id="arCOG00938">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_803196_0_0_2"/>
    <dbReference type="OrthoDB" id="6098at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050377">
        <property type="entry name" value="Radical_SAM_PqqE_MftC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11228:SF7">
        <property type="entry name" value="PQQA PEPTIDE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11228">
        <property type="entry name" value="RADICAL SAM DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01067">
        <property type="entry name" value="SPASM/twitch_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="49"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF83709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="387" mass="44383" checksum="69AA803ACACF79CE" modified="2014-10-29" version="1">MPSLLAFAYGITRQKYSGHFTKNITMGGVDTIRTLKLLGKWSANRAVGRRRPLIAVFSMTHYCNFYCPMCPFGDADKEGQIATAKRRDLTTEQWKAVFDKVSKYCVWAIVEGGEPTSRPDFMELVKYLHGLKMPITLISNCSLLHTIDLDELKKHIQFVTCSIDSTYEEPYCKVRGVNPHMYRRVMDNLRLLTEHKVPHYLNSVITKYNTEEFIDQTYFDRAKELGASAVSFTFVEDRSDVDYSLLPDRQTMNKVCESILDYMGKQQKAGGLPVMIPQEYFQQILEHGRGLFDECGVWKSIFVNGDGTVMVPCWKFNSPENTYSLLEHSVDEIWSAPQWDIARTCHDCEVLGCIWYSSQPVSTFARNYMRGLGKIISQERPELAEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWT9</accession>
    <name>A0A075MWT9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AAA family ATPase, CDC48 subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NTE_01658</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. CDC48 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWT9"/>
    <dbReference type="STRING" id="1459636.NTE_01658"/>
    <dbReference type="KEGG" id="nev:NTE_01658"/>
    <dbReference type="eggNOG" id="arCOG01308">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_12_2_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000007">
        <property type="entry name" value="AAA family ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000057">
        <property type="entry name" value="AAA family ATPase, CDC48 subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001025">
        <property type="entry name" value="ATPase family, AAA domain-containing 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000012">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005938">
        <property type="entry name" value="AAA_ATPase_CDC48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004201">
        <property type="entry name" value="Cdc48_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003338">
        <property type="entry name" value="CDC4_N-term_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01243">
        <property type="entry name" value="CDC48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF171">
        <property type="entry name" value="NUCLEAR VALOSIN-CONTAINING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02933">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02359">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01072">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01073">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CDC48 N-terminal subdomain" evidence="8">
        <location>
            <begin position="18"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="CDC48" evidence="7">
        <location>
            <begin position="119"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="223"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="496"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF83719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="734" mass="81399" checksum="9224394A1D5DCB3E" modified="2014-10-29" version="1">MYRLKKAKAGSDESPQVQLRVAEAKHRDVGKCRARLDPHYMEQIGVQPGEVIEITGKRATAVTAWPADDEEQDTDIIRIDGQTRKNAGVGLNDLLNVRKAESKAAKSITLMPIGDSNITVDKEFCEFVKGRLKGFPMSEGDEISVVILGNSMDFKVQKISPKAIVRVERSTKLAIMAETAQDRKPRVTYEEIGGMKEQIKRLREIVELPMRHPEVFARLGIEPHSGILMYGPPGTGKTLIAKALASESEANFFIINGPEIMNKYYGETEARLRDIFKEAKESSPSIIFIDEIDAIAPKREEAFGDVEKRVVAQLLALMDGMQERGQVIVLGATNRPESLDPALRRPGRFDREIEIGVPNAEGRLEILQIHTRGMPLDDDINLQELASELHGYTGADIKALCREAAMKALRRYLPEIDLEGDKISPEVLEQMVITTKDFRDGIKEIVPTAMREFYVEVARVKWTEVGGLYDAKRVLHDNLITSIKEPESFSKMGIKPPKGALLYGPSGTGKTLIAKALATESNANIIIVRGPEVLSKWVGESEKAIREIFRKAKTSSPCIVVFDELDSLARPRGQSEDGAGNERVVSQILTEMDDAGNSGVIIVGITNRPDLIDPSLLRPGRLDLIVYIGQPDEKARFEILKIITQPMPLESDVDLASIAQTTRNFSGADLFALCREAAVSAMQRKSPTISNTDFAQALRAARPSITKEVEEWYESMKKSLTYAMPKPIDKSFYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWU2</accession>
    <name>A0A075MWU2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Plastocyanin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NTE_01663</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700443.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWU2"/>
    <dbReference type="STRING" id="1459636.NTE_01663"/>
    <dbReference type="GeneID" id="41597438"/>
    <dbReference type="KEGG" id="nev:NTE_01663"/>
    <dbReference type="eggNOG" id="arCOG02926">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG02929">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG04151">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051300_0_0_2"/>
    <dbReference type="OrthoDB" id="11836at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000923">
        <property type="entry name" value="BlueCu_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028096">
        <property type="entry name" value="EfeO_Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052721">
        <property type="entry name" value="ET_Amicyanin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36507">
        <property type="entry name" value="BLL1555 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36507:SF1">
        <property type="entry name" value="BLL1555 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00127">
        <property type="entry name" value="Copper-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13473">
        <property type="entry name" value="Cupredoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="EfeO-type cupredoxin-like" evidence="6">
        <location>
            <begin position="191"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Blue (type 1) copper" evidence="5">
        <location>
            <begin position="356"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="184"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="270"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="207"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="271"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF83724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="436" mass="44072" checksum="4F5FB43BDDE35DEA" modified="2014-10-29" version="1">MTDWDLLTPGIGLTSIGIVGVGISLAGIAKTFIDGMHAVSLLTMFIGMIFLASGLFKDGFPSTGRAKSATFITLGFLVTFGVAAAVTVSVQVPSIFAYIGLMAMIGIPGAVLAVTSFRKPQYVKAMGVIFIAGAAVGGITFYAFGLVTPKPPQPAEEEQQQPAAPAAPATPPANVIKASIPAGASAQGNPSYDPNPLTVAKGDGVEWTNNDNVPHTVTSKADSGKTFDSKVMAAGKTFLLNTATLKEGDYEYYCQLHPFMDGMLKVGGAGASSAAGGNATSSSGNATGGNAATQSSGGNATTGSSAATANNNTNATAPSGNATSAPSTASGGAKTAATVTSVSIVLGASTPTNGQFFSPAEAKSAVGSMVTWTNHDTTLHTVTSGKVVNNTPAPDKVFDSGLMKAGASYSYVFEKAGEYDYYCMLHPYMTGKVTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWU6</accession>
    <name>A0A075MWU6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03088</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701574.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWU6"/>
    <dbReference type="STRING" id="1459636.NTE_03088"/>
    <dbReference type="GeneID" id="41598750"/>
    <dbReference type="KEGG" id="nev:NTE_03088"/>
    <dbReference type="HOGENOM" id="CLU_2379519_0_0_2"/>
    <dbReference type="OrthoDB" id="381305at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="99" mass="10573" checksum="9E525E4B0155C264" modified="2014-10-29" version="1">MAADKDDDEDNDSNNIIDILDTPDVAVWAKGIGKGAGAPSDRVKEPSKIVSMMPHIVKATTKKEGKGGMELMIDPASKKDMAKVSAEHASLTDESDYAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MX60</accession>
    <name>A0A075MX60_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rpl5</name>
        <name evidence="11" type="ORF">NTE_01824</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 50S ribosomal subunit; contacts the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MX60"/>
    <dbReference type="STRING" id="1459636.NTE_01824"/>
    <dbReference type="KEGG" id="nev:NTE_01824"/>
    <dbReference type="eggNOG" id="arCOG04092">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061015_3_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1440.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01333_A">
        <property type="entry name" value="Ribosomal_uL5_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_uL5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022804">
        <property type="entry name" value="Ribosomal_uL5_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_uL5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_uL5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057266">
        <property type="entry name" value="Ribosomal_uL5_euk/arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031310">
        <property type="entry name" value="Ribosomal_uL5_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003258">
        <property type="entry name" value="PRK04219.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00281">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002161">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="RL5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL5 N-terminal" evidence="9">
        <location>
            <begin position="5"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL5 C-terminal" evidence="10">
        <location>
            <begin position="61"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIF83884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="170" mass="18952" checksum="5459F41535054CDD" modified="2014-10-29" version="1">MESSSMKRIAVDKVVINIGVGKSGEPMEKAKKALTELTGHQPAIRGAKKTVRDFGIHQGEPIGAMVTLRRQEAIEFLKRVIAAKRNVLKESSFDNFGNLSIGIHEHIDIPGTKYNPEIGIFGMDVNIVLIRPGYRIARKSRKRAKVGKSHRITKEDAIAYFREQFGAEVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MXF9</accession>
    <name>A0A075MXF9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative zinc ribbon domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03273</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701732.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MXF9"/>
    <dbReference type="GeneID" id="41598928"/>
    <dbReference type="KEGG" id="nev:NTE_03273"/>
    <dbReference type="eggNOG" id="arCOG07681">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_175260_0_0_2"/>
    <dbReference type="OrthoDB" id="72884at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025868">
        <property type="entry name" value="Zn_ribbon_dom_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12674">
        <property type="entry name" value="Zn_ribbon_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative zinc ribbon" evidence="1">
        <location>
            <begin position="11"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="89" mass="9702" checksum="959B9F9652251338" modified="2014-10-29" version="1">MSDPSSTTSRCQSCGIPLGDGFYGTDGNGSATKEYCKFCFQAGAFTMPDLTVEDMIKRSVDFMTKNLGIPAQKAEEMSRAVISGLKRWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MXL5</accession>
    <name>A0A075MXL5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Methionine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Methionyl-tRNA synthetase</fullName>
            <shortName evidence="8">MetRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">metG</name>
        <name evidence="12" type="ORF">NTE_03323</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>tRNA(Met) + L-methionine + ATP = L-methionyl-tRNA(Met) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="8"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701771.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MXL5"/>
    <dbReference type="STRING" id="1459636.NTE_03323"/>
    <dbReference type="GeneID" id="41598974"/>
    <dbReference type="KEGG" id="nev:NTE_03323"/>
    <dbReference type="eggNOG" id="arCOG00810">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009710_1_2_2"/>
    <dbReference type="OrthoDB" id="371856at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07957">
        <property type="entry name" value="Anticodon_Ia_Met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.20">
        <property type="entry name" value="Methionyl-tRNA synthetase, Zn-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00098">
        <property type="entry name" value="Met_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041872">
        <property type="entry name" value="Anticodon_Met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023458">
        <property type="entry name" value="Met-tRNA_ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029038">
        <property type="entry name" value="MetRS_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001100">
        <property type="entry name" value="PRK00133.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765">
        <property type="entry name" value="METHIONINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765:SF1">
        <property type="entry name" value="METHIONINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19303">
        <property type="entry name" value="Anticodon_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57770">
        <property type="entry name" value="Methionyl-tRNA synthetase (MetRS), Zn-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Methionyl/Leucyl tRNA synthetase" evidence="10">
        <location>
            <begin position="9"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl-tRNA synthetase anticodon-binding" evidence="11">
        <location>
            <begin position="407"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="8">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="331"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF19303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIF85352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="553" mass="63516" checksum="49DA4CC2454803E3" modified="2014-10-29" version="1">MPESSKSAIITSALPYANGEIHLGHIASTYLPADIFTRFSRLNGREAYHICASDDFGTPILIKAEKEGKTPEEYVALWNRRDYDDFAALGISFDFFYRTSSPENVGFVQYVFTKLRENGHTYEHDIVQFYCEFDDKFLPDRYVVGRCPFCGAENQYSDLCEKCGRVPDEILDPKCAICGRPPVKKHSTHYFFKLSNFSDKLKSWLLSNQNLQPDVKNYVINWIDEGLQEWDITRDLSWGVPIPLPDAKGKVFYGWFDNHLCYISTMTKFMEDKGRDGKKFWNESEIYHFIGKDIVYHHYLFLPAMRLGINEEYKLPDWIPTRGHLMLQNQKISKSRNWYIGLKQFLEAFPADYLRFYMASIVTYSQDDLNFDFDSFAEKINNELIANVGNFVNRALSFTQKAYSGKVPEPGELGGDERIAKGMIESAVRDVGELLSANETDKALKKIMELSTYFNQYFQKKKPWSEKETAGTTLYVAVNAARTLAILLEPFIPFSCEKIWAQLNLQGSVHGQSWQSAAEFAVPAGHQLGKVEPIFKKIEAKEIEQQKAKLGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MXW9</accession>
    <name>A0A075MXW9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative esterase of the alpha-beta hydrolase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_03444</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MXW9"/>
    <dbReference type="KEGG" id="nev:NTE_03444"/>
    <dbReference type="eggNOG" id="arCOG09020">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042894_1_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF57">
        <property type="entry name" value="BLR7027 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="4">
        <location>
            <begin position="1"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF85472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="358" mass="40398" checksum="ECA1A29CBEE18DAC" modified="2014-10-29" version="1">MQGGGSLGAYECGVYKALSKRDIKFDIVAGTSIGAVNAAIVAGSKNDNPEGDLEDFWLDVAERVTGSIISDNLRAVMSSWYAALYGNAKIFSPAWYTTPSLNYTPLGHFTSIRPPYMYDLAILKRTLERYVDFSKLNSNNVPRLIVTATDIKNSKAVLFDSMATNIDADHILACASYPFYGIGWTEKDGKFLWDGALLSNTPLREVIEASPKRDKKVYIVNLFPHVQEELPENMFDIWHRARDIMHTDKTDSNVRLSKAISGYLLLLREMHDILSNAPLDKELHERFTKIEPEYHKLADARGAIIDEITKIERREKVHFLFEDADFSLATIKNLIKQGEEDAEKVIVEKEKGKADDRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MY02</accession>
    <name>A0A075MY02_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MY02"/>
    <dbReference type="KEGG" id="nev:NTE_03494"/>
    <dbReference type="HOGENOM" id="CLU_2874909_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="65" mass="7288" checksum="42A9B699A25BC6FD" modified="2014-10-29" version="1">MDRDFIILAAILVAIGLAGIYAGLISHPIMYINSAVLFGYAGYVTWQSFRVRKAATTRRRKKEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MZ99</accession>
    <name>A0A075MZ99_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701123.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MZ99"/>
    <dbReference type="STRING" id="1459636.NTE_02525"/>
    <dbReference type="GeneID" id="41598226"/>
    <dbReference type="KEGG" id="nev:NTE_02525"/>
    <dbReference type="HOGENOM" id="CLU_961738_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="289" mass="33885" checksum="584A662BD8D2CF73" modified="2014-10-29" version="1">MTKVIEAKVYKPITGPFLEDEIRLMSRHRAEQIRWYGAQKVISEEMISDLQVDSEQELKNQILSLCQHYDSYPVLIELDNTTLNRTFIVDHMTGISDKKAIFENVYYAYTEKAKIIQASMDEKMERHRQQLQATLQQHGYSMYLFIDAITGGKAIPINEYLTDEEIEENLKEQHPRERAILLDIVKKFRGWAPRMYAEIASEFEIPVESFRTDDGLNPIYYSPYVIASKAEERDSQPLDINSVKYWFLEERGRIIGRVDAKARVDFQSWFTSFHLKMASNDTRYISNAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N1I0</accession>
    <name>A0A075N1I0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase involved in chromosome partitioning</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701749.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N1I0"/>
    <dbReference type="STRING" id="1459636.NTE_03295"/>
    <dbReference type="GeneID" id="41598949"/>
    <dbReference type="KEGG" id="nev:NTE_03295"/>
    <dbReference type="eggNOG" id="arCOG00589">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096711_0_0_2"/>
    <dbReference type="OrthoDB" id="36110at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050678">
        <property type="entry name" value="DNA_Partitioning_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13696">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13696:SF52">
        <property type="entry name" value="PARA FAMILY PROTEIN CT_582"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobQ/CobB/MinD/ParA nucleotide binding" evidence="1">
        <location>
            <begin position="8"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="291" mass="32221" checksum="1D385CBAE6329267" modified="2014-10-29" version="1">MPTTKCVAFHSYKGGTGKTTIAANCAALLAKKGFKVALLDLDVYAPSLYTYFGSEPRKWLNDYLLGDAAVEDVMTDVTETVREYTRKYDAGGRVQDGGRLWLGFCSMRKEEVYKLDSSTAESSKSQLRRFILLREQLISNYDLDYIIIDTSPGIRYWSINALAVADALFLTLKMGDIDIEGTNKLASEIYSSLTKYGTRSFLLLNRVAGYCVPEAHFAGSDDVRMAVTEEGDSADIAGVLAGKTGMEVISSIPCYCDIQFSRKEFLTALVQPGHPFTKQVERLIEAVQIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N1V2</accession>
    <name>A0A075N1V2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03406</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701846.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N1V2"/>
    <dbReference type="STRING" id="1459636.NTE_03406"/>
    <dbReference type="GeneID" id="41599051"/>
    <dbReference type="KEGG" id="nev:NTE_03406"/>
    <dbReference type="HOGENOM" id="CLU_2930034_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="60" mass="6971" checksum="9544A8C88E000585" modified="2014-10-29" version="1">MEPELLTIAGQFGLGGFGLYLLFRIFQIQQKTFSCHLTDLHKDNVRTHNLLEDLLRALRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N256</accession>
    <name>A0A075N256_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03501</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N256"/>
    <dbReference type="KEGG" id="nev:NTE_03501"/>
    <dbReference type="HOGENOM" id="CLU_2765847_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="69" mass="8046" checksum="0F96AB7B9501ED11" modified="2014-10-29" version="1">MNFKSFPDYWEPFLMGQGPAGAYLKHIGHDHLPILREEVKRQLRLRDETAPFILRGQVWAVRGSVPESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLN7</accession>
    <name>A0A075MLN7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Short-chain alcohol dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_00111</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987088.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLN7"/>
    <dbReference type="STRING" id="1459636.NTE_00111"/>
    <dbReference type="GeneID" id="41596053"/>
    <dbReference type="KEGG" id="nev:NTE_00111"/>
    <dbReference type="eggNOG" id="arCOG01264">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_44_5_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05327">
        <property type="entry name" value="retinol-DH_like_SDR_c_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF82193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="288" mass="31088" checksum="70860C600606200E" modified="2014-10-29" version="1">MMTMEGKICLVTGSTSGIGKEIAAGLAEMGAKVVLVGRSREKCETAIQDVIAMTADSRVSSGLLSYLVADLSSQQSVRQLAKDFADSHDRLHVLVNNAGVFMSKRELTVDGIEYTLAVNHLAPFLLTNLLLGRLKAGAPSRIITTSSVAHRGIKIDFDDLQMMNKGYSGIRAYGQSKLANILFTRELARRRLQGTGVTANCFHPGAVRTNLVRGSSYGLVWGAASVFFTSPQKGADTAIYLASSDEIKNVSGEYFVKRKQAKASDAAYDDDAAERLWRASEQLTGIQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MM38</accession>
    <name>A0A075MM38_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methylase involved in ubiquinone/menaquinone biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699324.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MM38"/>
    <dbReference type="STRING" id="1459636.NTE_00231"/>
    <dbReference type="GeneID" id="41596150"/>
    <dbReference type="KEGG" id="nev:NTE_00231"/>
    <dbReference type="eggNOG" id="arCOG01792">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037990_2_4_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="1">
        <location>
            <begin position="36"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="265" mass="30002" checksum="95BC51ABF46EF749" modified="2014-10-29" version="1">MFTNAHAYDRFMGRWSRLVAPLLIEFAKLPESGQILDVGCGIGSLAFTIARLRPHCNVLGIDASSDYIGYAKSQIRSSSRRIQLKVGDAQNLPFPDAMFDSSLSLLVLNFIPDARRAVYQMTRVTRPRGRVVAAVWDYGGRMEMLRIFWDAAVALDTDAERFDERKMPLCHEGELSALWRSAGLYDISEHPLEVKMNFKSFPDYWDPFLLGQGPAGAYVRRIGKDRSLMTLREDLRERLGLQDETTPFTLHGQVWAVRGSVPESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MM44</accession>
    <name>A0A075MM44_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Late embryogenesis abundant protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00241</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699330.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MM44"/>
    <dbReference type="STRING" id="1459636.NTE_00241"/>
    <dbReference type="GeneID" id="41596156"/>
    <dbReference type="KEGG" id="nev:NTE_00241"/>
    <dbReference type="HOGENOM" id="CLU_2856917_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.700">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="64" mass="6697" checksum="AE3BF7B59C573211" modified="2014-10-29" version="1">MSDIEQDAKNAAKKAREGVEDAAEDARKSTEDAATKVKEGAADAADKASSAFDKAKEKAKDALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MM74</accession>
    <name>A0A075MM74_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MM74"/>
    <dbReference type="STRING" id="1459636.NTE_00505"/>
    <dbReference type="KEGG" id="nev:NTE_00505"/>
    <dbReference type="HOGENOM" id="CLU_087546_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="237" mass="26175" checksum="9409F577C02A3E38" modified="2014-10-29" version="1">MADLIRVQEPFYNSRTNANQVLSSFPRSPRLIKGALISYDPAGFVPQVIIFQYNPETLTRQVQSNRLQQTISTVETQRLTGPPKETITLKIEIDAADRLEKPEQNPSTVAMGIYPQLSALEMMIYPKSSWAIEKNALAATGAIEIAPPEGPFTLFVWGPSRVVPVKISNFTITEQYYDQLLNPIVAEVSVSLDVLTYNDFRVTHPGYSVFLSHQILKETMAAIGSITSVSGTISGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMB5</accession>
    <name>A0A075MMB5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699556.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMB5"/>
    <dbReference type="GeneID" id="41596411"/>
    <dbReference type="KEGG" id="nev:NTE_00540"/>
    <dbReference type="HOGENOM" id="CLU_2313648_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="99" mass="11595" checksum="5AB2B3F353772C1A" modified="2014-10-29" version="1">MRDWEEPDNNNGGRKKKTLVNRMYEQMNALTPRRGYNLVRIDPWSIQDEDDALTLIGHFDTYQEAADAKKKYPTHNTTIYGPRNREVDIKGWQRAVALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMD3</accession>
    <name>A0A075MMD3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Zinc metalloprotease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">NTE_00331</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">SR1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="14 16">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14 16">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the peptidase M50B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699396.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMD3"/>
    <dbReference type="STRING" id="1459636.NTE_00331"/>
    <dbReference type="GeneID" id="41596228"/>
    <dbReference type="KEGG" id="nev:NTE_00331"/>
    <dbReference type="eggNOG" id="arCOG00607">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037123_1_2_2"/>
    <dbReference type="OrthoDB" id="12044at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06164">
        <property type="entry name" value="S2P-M50_SpoIVFB_CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016483">
        <property type="entry name" value="UCP006404_Pept_M50_CBS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39188">
        <property type="entry name" value="MEMBRANE-ASSOCIATED ZINC METALLOPROTEASE M50B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39188:SF3">
        <property type="entry name" value="STAGE IV SPORULATION PROTEIN FB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006404">
        <property type="entry name" value="UCP006404_Pept_M50_CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 17" id="KW-0129">CBS domain</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 14 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 14 19" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9 14 16" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="197"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="18">
        <location>
            <begin position="252"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="18">
        <location>
            <begin position="319"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="active site" evidence="15">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR006404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR006404-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR006404-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="AIF82413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="383" mass="42220" checksum="FA16F399F6759B4F" modified="2014-10-29" version="1">MSVQIGRVKGVPIRLHFTLLIVFSLVTWSLAANFMPQFFPGLSSAEYWIMGVAGAILLFISVLLHELSHSVLAMRFGIKVRQIMLFIFGGVSDIEEEPKNPQKEFQIAIAGPATSFVLSAIFAGLWAISAAINDVPVFEGIMLYGAIINALLGAFNLLPAFPLDGGRVLRAVLVKRTKRDFDQATDTSVKVGIAISYVMMGLGFVTILTGNGFVSGIWLILIGWFLQSGAQSYRYQHELTAILSKVRMRDIMNISFIAIPPETSLQESLQRYFSVYMKSAFPVTDAAGRLLGMVTLKRVMDSSGDDESKRQVLTVREVMMPLEELNVVSPDTRGDEAVKKMTSSGIGKIFVCDLEGRLLGMVTKTDLLNVVSERQEYSKTVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMD4</accession>
    <name>A0A075MMD4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699566.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMD4"/>
    <dbReference type="GeneID" id="41596423"/>
    <dbReference type="KEGG" id="nev:NTE_00555"/>
    <dbReference type="HOGENOM" id="CLU_2461617_0_0_2"/>
    <dbReference type="OrthoDB" id="375486at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="88" mass="9518" checksum="A287007FADC6705A" modified="2014-10-29" version="1">MSADGATTTNNTNPSSSSPPSKPKSNKIAFAVIRMPDGIEHEIPLPPKTFSSGREGCYAQIPGFFYNDEVYGGQIQVWKKGEKGQQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMF6</accession>
    <name>A0A075MMF6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Archaeal serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_00351</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699409.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMF6"/>
    <dbReference type="GeneID" id="41596241"/>
    <dbReference type="KEGG" id="nev:NTE_00351"/>
    <dbReference type="eggNOG" id="arCOG01937">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_867689_0_0_2"/>
    <dbReference type="OrthoDB" id="15525at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="ATP DEPENDENT LON PROTEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lon proteolytic" evidence="3">
        <location>
            <begin position="196"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="44"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF82433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="320" mass="33880" checksum="0E626C60A4FBD6A5" modified="2014-10-29" version="1">MTAKITILLGILIIASAFANVYLYQKTASLENTVTQLQNTNRKLTDSLGNANSNNNNNNQNSTTIGSSSPPPPATGVLPPTSNRSQQQNSKFLLNTTSQSITAVAVKAVPVTDGFFQTVQYQGVAIDITVDIRDNGKGLVLVNTEIPTGVDFQTSARTAVKVAQSMTKADLSNKDVIFSIKSKGGNSTSTDLQAVDGPSAGAAMTALLAAELGAIGNNNAELKQDVVMTGTIEPDGTIGPVGGVPEKAIAAGQYGAKIFLVPSGQAVYNEQTCEKKQEGIFIYQTCRSQEKPLSDYTEKNYGMKVIEVKNIKDALTYFQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMI6</accession>
    <name>A0A075MMI6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00381</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMI6"/>
    <dbReference type="STRING" id="1459636.NTE_00381"/>
    <dbReference type="KEGG" id="nev:NTE_00381"/>
    <dbReference type="HOGENOM" id="CLU_206903_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="64" mass="7201" checksum="091F6374EE3B1165" modified="2014-10-29" version="1">MNGNNQELGSLIPNLYVTWSAMNLLESISWVALGFVPTFAAMEAAWRMAKWRQAKLFGATQVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMQ2</accession>
    <name>A0A075MMQ2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribonuclease VapC</fullName>
            <shortName evidence="8">RNase VapC</shortName>
            <ecNumber evidence="8">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Putative toxin VapC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">vapC</name>
        <name evidence="10" type="ORF">NTE_00471</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Toxic component of a toxin-antitoxin (TA) system. An RNase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the PINc/VapC protein family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="8"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699503.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMQ2"/>
    <dbReference type="GeneID" id="41596346"/>
    <dbReference type="KEGG" id="nev:NTE_00471"/>
    <dbReference type="eggNOG" id="arCOG02219">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118482_3_2_2"/>
    <dbReference type="OrthoDB" id="11616at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:RNA nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09881">
        <property type="entry name" value="PIN_VapC4-5_FitB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00265">
        <property type="entry name" value="VapC_Nob1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050556">
        <property type="entry name" value="Type_II_TA_system_RNase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022907">
        <property type="entry name" value="VapC_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33653">
        <property type="entry name" value="RIBONUCLEASE VAPC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33653:SF1">
        <property type="entry name" value="RIBONUCLEASE VAPC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0800">Toxin</keyword>
    <keyword evidence="2 8" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="domain" description="PIN" evidence="9">
        <location>
            <begin position="8"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="5"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIF82553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="129" mass="14432" checksum="7165B23B1D690CED" modified="2014-10-29" version="1">MVCADSDFIADLDRGSPAAIAKLDELEQRGEPVYTTTINVAELYHGAHASRNTDRAIGRIEKILSRFSILNLDYGSARLWGELADKLKSNSIGELDLFIASMALTNKQSIVTRNRKHFERVPGLRIESW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMR4</accession>
    <name>A0A075MMR4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00363</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699420.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMR4"/>
    <dbReference type="GeneID" id="41596255"/>
    <dbReference type="KEGG" id="nev:NTE_00363"/>
    <dbReference type="eggNOG" id="arCOG10358">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124267_0_0_2"/>
    <dbReference type="OrthoDB" id="12289at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="151" mass="16349" checksum="DF86EA5E24E1CA82" modified="2014-10-29" version="1">MSIKRNSSRLILGLAFAAVLIFSAASMGKSVSAQGNNNNNATASGGETAATITPLQYIANIKQLLGEIQTEYNNGNATRAEELAVQAYLDNFENVEGPLAQAGQRDLMEQLEHMLREELRQKIRDKVSSDELAAFISTINTKLGEAEKAFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMR8</accession>
    <name>A0A075MMR8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CHAD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699198.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMR8"/>
    <dbReference type="STRING" id="1459636.NTE_00053"/>
    <dbReference type="GeneID" id="41596004"/>
    <dbReference type="KEGG" id="nev:NTE_00053"/>
    <dbReference type="HOGENOM" id="CLU_1003323_0_0_2"/>
    <dbReference type="OrthoDB" id="11137at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.40.20.10">
        <property type="entry name" value="CHAD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007899">
        <property type="entry name" value="CHAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038186">
        <property type="entry name" value="CHAD_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39339:SF1">
        <property type="entry name" value="CHAD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39339">
        <property type="entry name" value="SLR1444 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05235">
        <property type="entry name" value="CHAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00880">
        <property type="entry name" value="CHAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHAD" evidence="1">
        <location>
            <begin position="12"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="279" mass="30994" checksum="2FC6B579FFFB222C" modified="2014-10-29" version="1">MQQGKTTQFEKNFEASSARVKKRLAAYLRDPEDGKNVHAMRTSLRRLEAAFLLLPKKERKRNKKQADACKAFFRANSRVRDLDIISAKITALGGDPFVDAIAGKRKAALVHALALARSLEKNKMPLAANAIKKKKSIDGDKLAARMDKVAGRLVCAIEERLPVVVGDSSKKEELHGLRKDLKKLRYMLEILPAGRRKKYERAVAKVVVGGSNSNSGSNNVMARLKELQGTLGLVRDCDITIEYLQRVKGAGAVLQKGKDERDALYEKFAKNMMMTIMAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMX8</accession>
    <name>A0A075MMX8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF3892 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00542</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699557.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMX8"/>
    <dbReference type="GeneID" id="41596412"/>
    <dbReference type="KEGG" id="nev:NTE_00542"/>
    <dbReference type="HOGENOM" id="CLU_2433695_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024997">
        <property type="entry name" value="DUF3892"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13031">
        <property type="entry name" value="DUF3892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="90" mass="10275" checksum="D0B25B7052751F6F" modified="2014-10-29" version="1">MEEFRIRCKVNDASGRLAKVAIGVDQFTVEQIWNWIATNKYAFYTEENGIKAPVKHVQKGRRKYITTAPDGITENNLAELQICKVNMGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMY0</accession>
    <name>A0A075MMY0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Lysine biosynthesis enzyme LysX</fullName>
            <ecNumber evidence="12">6.3.2.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NTE_00733</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SR1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amino-acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RimK family. LysX subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.-" evidence="12"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699709.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMY0"/>
    <dbReference type="STRING" id="1459636.NTE_00733"/>
    <dbReference type="GeneID" id="41596585"/>
    <dbReference type="KEGG" id="nev:NTE_00733"/>
    <dbReference type="eggNOG" id="arCOG01589">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054353_2_1_2"/>
    <dbReference type="OrthoDB" id="33241at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043774">
        <property type="term" value="F:coenzyme F420-2 alpha-glutamyl ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009085">
        <property type="term" value="P:lysine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000058">
        <property type="entry name" value="Alpha-aminoadipate--LysW ligase LysX protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013651">
        <property type="entry name" value="ATP-grasp_RimK-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054562">
        <property type="entry name" value="LysX/ArgX_preATP_grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011870">
        <property type="entry name" value="LysX_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004666">
        <property type="entry name" value="Rp_bS6_RimK/Lys_biosynth_LsyX"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02144">
        <property type="entry name" value="LysX_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00768">
        <property type="entry name" value="rimK_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21621:SF2">
        <property type="entry name" value="COENZYME GAMMA-F420-2:ALPHA-L-GLUTAMATE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21621">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 MODIFICATION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22626">
        <property type="entry name" value="LysX_preATP_grasp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08443">
        <property type="entry name" value="RimK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="11">
        <location>
            <begin position="96"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIF82811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="287" mass="31687" checksum="F34569CDC5A3317E" modified="2014-10-29" version="1">MAVELCIIYDKVRFEEKALYDKALEKGLKAQIVDGKNITVGTESKKSDLALGDVVMQRSVSHYRGLYLTACLEFLDYPVINKFQTAETCGNKLVTSLVLAKNNIPTPKTQMAFSAESAIEVIRKTGLPLVLKPIVGSWGRGVFPLRDDETASMIVEMREENDSPLARIYYVQEMIDRPPRDIRCIVVGDRVVTAIYRYSAENEWRTNVARGGKAELAPMTKELEDLALRAAKAVGGGIVGVDLMEDKNRGLVVHEVNNTVEFRGAASVSTNDIPGAMIDYAVSLVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMY9</accession>
    <name>A0A075MMY9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HEPN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00438</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMY9"/>
    <dbReference type="STRING" id="1459636.NTE_00438"/>
    <dbReference type="KEGG" id="nev:NTE_00438"/>
    <dbReference type="HOGENOM" id="CLU_1830655_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="149" mass="17201" checksum="F1895882ABE609FB" modified="2014-10-29" version="1">MGRHSCSAHMPPYQDADEGHRILIDDVLAHCRQVFGQGLQLEAILLAHEYLEQRLNNFYKHGDVQVHRKFKHIIDALHSNRHLSDEDYTVLNEFNRLRNINSHRALDDTLELRGAKKGDMARAMDLAQECDAIISRLPKKRAAGKKKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMZ2</accession>
    <name>A0A075MMZ2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CBS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_00552</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699563.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMZ2"/>
    <dbReference type="STRING" id="1459636.NTE_00552"/>
    <dbReference type="GeneID" id="41596420"/>
    <dbReference type="KEGG" id="nev:NTE_00552"/>
    <dbReference type="eggNOG" id="arCOG00606">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040681_12_1_2"/>
    <dbReference type="OrthoDB" id="65817at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051257">
        <property type="entry name" value="Diverse_CBS-Domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43080:SF2">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43080">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN CBSX3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="4">
        <location>
            <begin position="30"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="4">
        <location>
            <begin position="121"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF82633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="216" mass="23302" checksum="9FBEC5FAB796056E" modified="2014-10-29" version="1">MTTTASSGNSRSNNDTAASSINVMPISSIMVQDVKTVSEEQTILDVCRVMHNNNIGSVVVVASKGQNKNPASYSSSSSSSSTTDGKQPSFDEPTGIITERDIVRHIALKLIAIQAPVHDVMSKPIVTVRPETSLTEAIQIMQTRDFRRLIVVNNEGGIIGIITDKDIFRAIARSRALISGLLSEQQPLPSSPTDRGGLLDQLEMEALTELFRPKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMZ5</accession>
    <name>A0A075MMZ5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Aminopeptidase N</fullName>
            <ecNumber evidence="12">3.4.11.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NTE_00443</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SR1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.2" evidence="12"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699479.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMZ5"/>
    <dbReference type="STRING" id="1459636.NTE_00443"/>
    <dbReference type="GeneID" id="41596319"/>
    <dbReference type="KEGG" id="nev:NTE_00443"/>
    <dbReference type="eggNOG" id="arCOG02969">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014298_0_1_2"/>
    <dbReference type="OrthoDB" id="139771at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016285">
        <property type="term" value="F:alanyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09603">
        <property type="entry name" value="M1_APN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000013">
        <property type="entry name" value="Aminopeptidase N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF174">
        <property type="entry name" value="PUROMYCIN-SENSITIVE AMINOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13646">
        <property type="entry name" value="HEAT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="11">
        <location>
            <begin position="28"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="10">
        <location>
            <begin position="234"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="798"/>
            <end position="825"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIF82525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="828" mass="94930" checksum="5164BAF56985E236" modified="2014-10-29" version="1">MQEETRRKFELAGSKAHYAPSLVFTISHMRLEIEPDLKAHTISCRQGLDIVAVQNTDEIELDAAELEVKSVLFGSSKKAVSFRNIDDRLVIKLPKPLKEGDRAQISISYSAKPRKGFYFVAPDKHYPNKRVEAWTQGETVEAKHWFPCIDHPQVKFSSETIVTVPEGFTAISNGRLANSEKNNSSKKCKYHWVESNSHPAYLTSVVVGKYVEINEGSLYYYVPTELAHDAKRSFDRTGDMVQFFEEYLGTRYPYEKYSQVCVQDFVYGGMENSSCTTLTQDTLHDRKAHVDFTSDHLVSHELAHQWFGDLVTCRDWQHIWLNEGFATYCEALYWEASRGINEFHYYTIQTADDYFDEAASRYVRPIVTKTYKHPDDLFDRHTYEKGGCVLHMLRNFVGDKYFRRSLKTYLQRFANGTAETDDLRKVFELETGKSLQQFFDQWVFREGHPDLKVEFSQDNKKTARIRVEQAQQQEPFSFALEVKLAFARGGDAKTYTFDVTGKESVFQIPVERQIEWFSVDPEFKVLKTVSVKAPKEMLVKQLHSGQTVVERVEAARALKEHSADIVVDALYKAVMNDRFWGVAAEAAKTLGAIRTDRAYRALEKCLKVSHPKARRAVVKALGDFKRHETIAMLRPYLHEESYFVESEALTAMGRTKSSDAVPILKKAVETTSFQNVVAQGAISGLKEFPDDRDIASLLVEKSRVGNHHRIREAATFALAKFVDSSNSNAVVDQLKLLLTDSWFRVRINACRAFADAEYVKAIPDLTRVSETDLDHRVRRVAEECINLIKDAAKKPKEVAQMRDELDRMKAKSLEMMQRMDRLERGGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MN22</accession>
    <name>A0A075MN22_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BFN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00823</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987152.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MN22"/>
    <dbReference type="GeneID" id="41596667"/>
    <dbReference type="KEGG" id="nev:NTE_00823"/>
    <dbReference type="eggNOG" id="arCOG01759">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1782437_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.690.10">
        <property type="entry name" value="Bifunctional nuclease domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036104">
        <property type="entry name" value="BFN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003729">
        <property type="entry name" value="Bi_nuclease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02577">
        <property type="entry name" value="BFN_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103256">
        <property type="entry name" value="Hypothetical protein TM0160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51658">
        <property type="entry name" value="BFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BFN" evidence="1">
        <location>
            <begin position="8"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="139" mass="15685" checksum="B843CE99D4CF8EBA" modified="2014-10-29" version="1">MLGREDEYVSARISYVGFVDQVGLEGVVILKAEDGREFPMRAFSGEVARHISRFQEGDKGAIPTIYNLVEEIAAMADLMLTEVRVYQSGTVLRANLYFQGRKGEIVLRNYRASDSIALASYYDTPIKVRKSLFEEALEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNB9</accession>
    <name>A0A075MNB9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNB9"/>
    <dbReference type="KEGG" id="nev:NTE_00220"/>
    <dbReference type="HOGENOM" id="CLU_2433694_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="90" mass="9028" checksum="258AAA61196DA69A" modified="2014-10-29" version="1">MTRTKTSCSRRTILLTGGSLLLVSVLAMAIFGTLAGPLHIAGIQSASAQGNNLTAFGNQTSGNMTASGNQTSSSDEEGDLAQGDPDGDGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNF0</accession>
    <name>A0A075MNF0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Fe-S cluster protector protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00658</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_075054845.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNF0"/>
    <dbReference type="STRING" id="1459636.NTE_00658"/>
    <dbReference type="GeneID" id="41596519"/>
    <dbReference type="KEGG" id="nev:NTE_00658"/>
    <dbReference type="eggNOG" id="arCOG10584">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2340016_0_0_2"/>
    <dbReference type="OrthoDB" id="6721at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3880.10">
        <property type="entry name" value="Fe(II) trafficking protein YggX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007457">
        <property type="entry name" value="Fe_traffick_prot_YggX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036766">
        <property type="entry name" value="Fe_traffick_prot_YggX_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04362">
        <property type="entry name" value="Iron_traffic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111148">
        <property type="entry name" value="YggX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="86" mass="9784" checksum="707EAEAAA5902CFF" modified="2014-10-29" version="1">MSGKTCLKCGKPIDAPSEDPAADKYPACNACWKEWTTYAIMVMNELRLDMSLPEHRKALRKYERAFFGLEKGIGEIEKKPEQPPSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNP0</accession>
    <name>A0A075MNP0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Phosphoglycerate dehydrogenase-like oxidoreductase</fullName>
            <ecNumber evidence="8">1.1.1.95</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NTE_00750</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.95" evidence="8"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699722.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNP0"/>
    <dbReference type="STRING" id="1459636.NTE_00750"/>
    <dbReference type="GeneID" id="41596602"/>
    <dbReference type="KEGG" id="nev:NTE_00750"/>
    <dbReference type="eggNOG" id="arCOG01754">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019796_1_3_2"/>
    <dbReference type="OrthoDB" id="7437at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004617">
        <property type="term" value="F:phosphoglycerate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12173">
        <property type="entry name" value="PGDH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000203">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase (SerA)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="D-2-hydroxyacid_DH"/>
    </dbReference>
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        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
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        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
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        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
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        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42789">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42789:SF1">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="6">
        <location>
            <begin position="7"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="7">
        <location>
            <begin position="109"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF82828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="310" mass="33405" checksum="69EEE70BBD54EEFA" modified="2014-10-29" version="1">MQVSGRVLVCDSIDQAGIDSMKRAGLAVDYKPEIKANELVATVKDYDVIVVRSRTKVTKEVIDAASSAKIIARVGVGLDNVDVKTAEAKKIRVINAPEAASVAVAELAIGLMISLARSIPRADAETKKGSWIKKDLMGTQLSGKYLGIVGVGNIGRHIGRMAKALHMNLIGYDPYPINKEFISETGMIVTDFNTLLESADYITCHVPSTPETKHMFNAERLAKMKPTAYLVNTSRGEIIDENALYEALKNGKLAGAALDVFEVEPPTNKLLLGLPNLVCTPHIGAQTKEGQELASTVIAEKIIQILRGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNQ9</accession>
    <name>A0A075MNQ9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Post-segregation antitoxin CcdA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_00685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNQ9"/>
    <dbReference type="STRING" id="1459636.NTE_00685"/>
    <dbReference type="KEGG" id="nev:NTE_00685"/>
    <dbReference type="HOGENOM" id="CLU_175270_1_2_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009956">
        <property type="entry name" value="Post-segregation_anti-tox_CcdA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07362">
        <property type="entry name" value="CcdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="24"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF82765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="76" mass="8792" checksum="07ABF09AD4E337AB" modified="2014-10-29" version="1">MLATETVSFRLSKELKDLAKKYGLNVSKIAKEKVEEELEKLQKEERKKMLEKAADVLEDVTKQDIVTAVRKSREAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MP80</accession>
    <name>A0A075MP80_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zn-dependent alcohol dehydrogenase</fullName>
            <ecNumber evidence="9">1.1.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NTE_00889</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.1" evidence="9"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699828.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MP80"/>
    <dbReference type="STRING" id="1459636.NTE_00889"/>
    <dbReference type="GeneID" id="41596729"/>
    <dbReference type="KEGG" id="nev:NTE_00889"/>
    <dbReference type="eggNOG" id="arCOG01455">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_2_2"/>
    <dbReference type="OrthoDB" id="73567at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05284">
        <property type="entry name" value="arabinose_DH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF8">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="8">
        <location>
            <begin position="17"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF82965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="353" mass="38107" checksum="3D72397CD7E65BF0" modified="2014-10-29" version="1">MTQTMLSARLHEYQKPLIVENVKVPNALGEGVVVKVGGAGLCHSDLHLINGEWKNAIPLALPKTPGHEVAGWVEEMGNLVPKGMFERGDLVAVFGGWGCGSCLACKRGDEQMCLIAKWPGLSQHDGGYSQYIAVPSYRFLIKVEGSRLRPEEIAPLTDAGLTPYRAIRRFRHVLVPGTAIAVIGIGGLGSYGIQYAKMLAPNSTTIAVDRSDKKLRFAKNLGAEHAIKLSENTRKEVMEITQGRGVDVVVDCVGAENTISASVALLAKGGALTLVGLFGTKICAPLMSTVINEYQITGSLWGNYNELREVIELAKQGKVKHTIQTFKLEDINNAINLLRNGQITGRAVITPNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPB7</accession>
    <name>A0A075MPB7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00556</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPB7"/>
    <dbReference type="KEGG" id="nev:NTE_00556"/>
    <dbReference type="HOGENOM" id="CLU_1212635_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="226" mass="24030" checksum="88AD503C5E52CB79" modified="2014-10-29" version="1">MRAVVVVILTAATATALLSFGMTAQADAQRVIVKPILQDTYRVKFIQVKVLNDHEGALSGDGEFKMFGGANGKQIFIDTCTPAAGKSDCDGGMNDVSPGEVVKLPASKYVDINVAPGGAINVGAYGIEEDWEGWTPPKLPTWAETTCKPIPGAHYVCDYWPQISKVASWLGAHLNSNEKLGVVNVAYTAPNYPSGNISVRSSTGDYILTFSIEKIGGVSPPLARQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPG8</accession>
    <name>A0A075MPG8_9ARCH</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">NTE_00960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_264357939.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPG8"/>
    <dbReference type="STRING" id="1459636.NTE_00960"/>
    <dbReference type="GeneID" id="75933613"/>
    <dbReference type="KEGG" id="nev:NTE_00960"/>
    <dbReference type="HOGENOM" id="CLU_3227630_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="43" mass="4563" checksum="8476C3109CB8C4AA" modified="2014-10-29" version="1">MADAMSTYAITIGIFVFLVGVLFATRAKRGHSPEAHEGHSESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPH3</accession>
    <name>A0A075MPH3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-propeller domain-containing protein, methanol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_00617</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699617.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPH3"/>
    <dbReference type="STRING" id="1459636.NTE_00617"/>
    <dbReference type="GeneID" id="43870433"/>
    <dbReference type="KEGG" id="nev:NTE_00617"/>
    <dbReference type="HOGENOM" id="CLU_965061_0_0_2"/>
    <dbReference type="OrthoDB" id="12136at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007621">
        <property type="entry name" value="TPM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30373">
        <property type="entry name" value="UPF0603 PROTEIN YGCG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30373:SF2">
        <property type="entry name" value="UPF0603 PROTEIN YGCG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04536">
        <property type="entry name" value="TPM_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="TPM" evidence="3">
        <location>
            <begin position="44"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF82697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="288" mass="29732" checksum="A6FAB55F11C988F3" modified="2014-10-29" version="1">MSAVVARALAFAFVFVVAAIVIVAFTVTPAFSQAAAKGSRPKYIYDNAEVITPEYRQLIDTYLRGLDDATTNEIVIYTIPSFVGHGIKKDGIEIHDRNMLANYIYNELPLDGIKGIGKSGKDNGVLVLMSLERDAGGGSMRIEVGRGLEGDITDGTAGEILDRYLVPARQEYEDTGSTAAFGRAFYNTVIALGAQADGTSVPTTDNSRPAADNDNTDAIMFGVFIAIFVAIVALNAKYGRRRRRGGYFVGGGYGGGYGGGWGGGGGGGGGGGGFGGGGGRSGGGGAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPH8</accession>
    <name>A0A075MPH8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699944.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPH8"/>
    <dbReference type="STRING" id="1459636.NTE_01045"/>
    <dbReference type="GeneID" id="41596868"/>
    <dbReference type="KEGG" id="nev:NTE_01045"/>
    <dbReference type="eggNOG" id="arCOG06357">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1021636_0_0_2"/>
    <dbReference type="OrthoDB" id="11273at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="280" mass="29611" checksum="D3CF6876D46594A3" modified="2014-10-29" version="1">MNARMIAAIFIIAGLVAVVYVFSIVPYLFGSSGKPSSALPVIQIIIPALAFPLIAVLVFLVPKRQVVTQAVSEHKTRDEAEYRYRIRSLWSGTAAGFFAAAILVSLIIGGDALLGLPLGTFYSIIGIAMGGLDVPVAIFFGTVLHLIMGTLIGAVFGYITTVVGPFNITSMAKGTGVGILAGFIAFSVLFVPLTRFEVEPSLVKVLASIYPPGTSAEVLQNKAIDVMSSVLAGSILLHVVYGAIMGSTTALLLGFPASETKREDYRADDAHNNHHNLTKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPK7</accession>
    <name>A0A075MPK7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01432</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700256.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPK7"/>
    <dbReference type="STRING" id="1459636.NTE_01432"/>
    <dbReference type="GeneID" id="41597227"/>
    <dbReference type="KEGG" id="nev:NTE_01432"/>
    <dbReference type="eggNOG" id="arCOG11426">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1387627_0_0_2"/>
    <dbReference type="OrthoDB" id="12196at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="188" mass="19159" checksum="5B06CB238F3D6232" modified="2014-10-29" version="1">MAQPNKSLLLGAVPGIALAALMVFVIPSSALVGAQNVTTDGLTPRGYVVVSVTRDGQEIYHNEQHNLITNAGKDFISAQIGSDSTGSNGANYIALTNTAITPVAGDTTLSGEITNNGLSRAQGTYAHTNGQSTFTVSKTFTATGATAAQAAGLFTASSGGTMMAENTFNAVSLAANDQLTITWTITLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPY9</accession>
    <name>A0A075MPY9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700369.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPY9"/>
    <dbReference type="GeneID" id="41597353"/>
    <dbReference type="KEGG" id="nev:NTE_01573"/>
    <dbReference type="eggNOG" id="arCOG01055">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_159725_0_0_2"/>
    <dbReference type="OrthoDB" id="140255at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038723">
        <property type="entry name" value="ArnR1-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14947">
        <property type="entry name" value="HTH_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ArnR1-like winged helix-turn-helix" evidence="1">
        <location>
            <begin position="4"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="95" mass="10889" checksum="DBC387785EFD37AC" modified="2014-10-29" version="1">MKNRSRMDIASAMLEIAQDGAIKTRIMYSAFISFPQLKEYLEILVDRGMLEYAPKEGVYRTTESGRRFLKTYKEVGQALYPKESKITKIASAGMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQ13</accession>
    <name>A0A075MQ13_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00876</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQ13"/>
    <dbReference type="STRING" id="1459636.NTE_00876"/>
    <dbReference type="KEGG" id="nev:NTE_00876"/>
    <dbReference type="HOGENOM" id="CLU_2313654_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="87" mass="9820" checksum="B205567413EB7723" modified="2014-10-29" version="1">MSKKGFYEILKYIDSRGPLHYNDILRHAQGTKVVDSRGQVNIIVNGLTSLGLLDRAVSLDKPVRTSYSISKKGKLVLEFLMRLEKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQ68</accession>
    <name>A0A075MQ68_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01258</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700116.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQ68"/>
    <dbReference type="STRING" id="1459636.NTE_01258"/>
    <dbReference type="GeneID" id="41597064"/>
    <dbReference type="KEGG" id="nev:NTE_01258"/>
    <dbReference type="eggNOG" id="arCOG08663">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1514546_0_0_2"/>
    <dbReference type="OrthoDB" id="8428at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="191" mass="21729" checksum="4C0191C468848A1F" modified="2014-10-29" version="1">MASLLPSSSSSSAVFRYYGASAWEIETLYDTLSRSYDVQDSEVPADDPQFVTMVEIGFPSPFGEPFFQEFTMESWFKVKGVLKDMKKRRGRKGVKTYIRFASFEGGKTPVVFPLLSKGDRQYEMGVEKLEYLVDIVPLQLKTVPKDAEEVWYSYEEATFKWSPATAMVNGVNYLYKNNEWVPPSAAKKSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQG2</accession>
    <name>A0A075MQG2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQG2"/>
    <dbReference type="STRING" id="1459636.NTE_01710"/>
    <dbReference type="KEGG" id="nev:NTE_01710"/>
    <dbReference type="eggNOG" id="arCOG10521">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_175994_0_0_2"/>
    <dbReference type="OrthoDB" id="5596at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="77" mass="8503" checksum="BC8D197DF2265721" modified="2014-10-29" version="1">MMQAEHCPVCAGKGVIEITDSQCPFCNGTGEPSRAAESYMKVHICQCIFLDRKNCPICGKKCHHNTPNRPKILIAPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQU5</accession>
    <name>A0A075MQU5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01856</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQU5"/>
    <dbReference type="KEGG" id="nev:NTE_01856"/>
    <dbReference type="HOGENOM" id="CLU_1280732_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="199"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="215" mass="25073" checksum="B7C2F87E39C2FBF8" modified="2014-10-29" version="1">MVGFRKKYKPYVPKYLPPQPKKVTWGFDSRDLIIKLFKRGFGIDDICRQTRNRRFFVESIIQRYEAGLPTCRQCGKRLSHNAHGEFYCSHRCYWDSRFNPYFPGQENRYHLPNCRNCGKPFKPRSDANLFCSWQCYIQCPNRMEIIPKRESTRSVVNNCRFCNAPVRVPKSHLKMGKGKYCGRACYAKARRSRHAPSHNPATATPNSPAPLQATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQZ0</accession>
    <name>A0A075MQZ0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700029.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQZ0"/>
    <dbReference type="STRING" id="1459636.NTE_01159"/>
    <dbReference type="GeneID" id="41596971"/>
    <dbReference type="KEGG" id="nev:NTE_01159"/>
    <dbReference type="HOGENOM" id="CLU_2447518_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="89" mass="10190" checksum="C34A4FE64E5C2B45" modified="2014-10-29" version="1">MSSDNDVDATEHQEIQEENDELQDEEQFEKDEEFEDQGFEYGTTLDDNPEHEYSEGRSEEKTEAAEEESDSARTETTSRRKRGGKGGHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MR58</accession>
    <name>A0A075MR58_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MR58"/>
    <dbReference type="KEGG" id="nev:NTE_01620"/>
    <dbReference type="HOGENOM" id="CLU_1782436_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="145" mass="16539" checksum="6DDA9426E8B075D9" modified="2014-10-29" version="1">MITGVLATSIRLPSTEEVRKLDISDLAIASALSDALRDRMREYVAIDPFTVVDPFDGDHTYSAVIDKENPNRVVAIIVNKRDSLPQLPWSTIMGERLAKIQMTKEEAKALKHEMMPKEWGNFYPYRRNGRVAGYFMFAFQVCGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRF2</accession>
    <name>A0A075MRF2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01672</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRF2"/>
    <dbReference type="STRING" id="1459636.NTE_01672"/>
    <dbReference type="KEGG" id="nev:NTE_01672"/>
    <dbReference type="HOGENOM" id="CLU_3194332_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="45" mass="5218" checksum="EA6FDAB7A7AF4DAB" modified="2014-10-29" version="1">MDGFRLLSGPLSALHGLKYKANLKVGLRHMVTDQYYLSIDNYFDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRF3</accession>
    <name>A0A075MRF3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SnoaL-like domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01607</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700398.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRF3"/>
    <dbReference type="STRING" id="1459636.NTE_01607"/>
    <dbReference type="GeneID" id="41597385"/>
    <dbReference type="KEGG" id="nev:NTE_01607"/>
    <dbReference type="HOGENOM" id="CLU_127472_0_0_2"/>
    <dbReference type="OrthoDB" id="10046at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030638">
        <property type="term" value="P:polyketide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009959">
        <property type="entry name" value="Cyclase_SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38436:SF3">
        <property type="entry name" value="CARBOXYMETHYLENEBUTENOLIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38436">
        <property type="entry name" value="POLYKETIDE CYCLASE SNOAL-LIKE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07366">
        <property type="entry name" value="SnoaL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="183" mass="20981" checksum="7F792628F53C4384" modified="2014-10-29" version="1">MKNDESSFKKHDNERFDARLDLGKVFDKHIQYEFENKDVDATMQTMTKEPYVHHVPVMTSGIGYEGVHNFYKDHFIGKMPADTKMERISRTVGKDHVVDELVISLTHDREIDFLLPSVKPTGKYLQIPVVVVMKFDEDGKIAHEHIYWDQASVLAQIGLLDAGVLPIVGLEQSRKLLELSKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRJ4</accession>
    <name>A0A075MRJ4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome segregation ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_01644</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700428.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRJ4"/>
    <dbReference type="STRING" id="1459636.NTE_01644"/>
    <dbReference type="GeneID" id="41597419"/>
    <dbReference type="KEGG" id="nev:NTE_01644"/>
    <dbReference type="eggNOG" id="arCOG00371">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001042_2_2_2"/>
    <dbReference type="OrthoDB" id="9143at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051276">
        <property type="term" value="P:chromosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43977">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="3">
        <location>
            <begin position="524"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="175"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="249"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="340"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="431"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="688"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="833"/>
            <end position="916"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF83705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="1184" mass="132437" checksum="D258CFE3C5A8D852" modified="2014-10-29" version="1">MVHIKKLEVYGFKSFGFRNTIVQFEKGLVAITGPNGSGKSNILDAIMFAIGENSPKAMRVDKFQSLFHDANNPGHRLIRVSVTFDNTDRGIPMDEDTVTLTREMEGQSGESQYLLNGKKVSKTAIMELLEVVLSAPNKLNIVQQGMITRISELNSEERRKIIEDIVGLSYFDEKKAEALKQLDEADRRLEVAFARMGEIRKRIDELEAERNDQLRYEQIGSELKRFKAVQLSNNIRVVRSKLATSTQILDGNNQRSAQLTKHLDELRQEIEGLETEKAKFMEEVDAANKAKAQLASKTASIVHDSERTKAMLGESQRRISDIERRLPQIEGGKQAIVQRAEGMKADADRLQASVAQKKEALAALRARLDQINAQVEEVSAVISRYTGLRQKLEGRLKRISSLKNSIEVSATRVEEKLKTNAYKKDAGDSALASLASEVDSAKARIAELQKSLESDKSRLQETINTISTLAETKIALERELAGSAAILSKADTMATKFEERASVAKHAMNEDFAIAELSKYSEKFGIKGIVHDLIRWDKGYERAVLAAGTEWMKAFVVEDVKSMIAIAAYAKEKKLPRLRIIPLDVVARYKSKRTEEFRGDTNVVGRVSDFVYCEYEALPEFLFSDSIVVKNSSAAYMLARQGFRAVSVEGELFEPAGGSMALDFGSKISDLTKAIILGDSVESLRDMLGKLSKVVEKKNAQLREAAERIASAESEKIRLEIQISSNETRLAQESASIAGKEKTMQEMQVQGQTLAHEAQILEAELEKYRRRLTLILPAVDRLSVRLQGIDESNAKAQLAEINVERNQIVKQADSANIELSQISSSLGGIESRLEFDQRELVQMDEEKERLTAELDQRKKQVEEMQSKAQALETELKALRDQEQQIIDSSGNAYSVLQEYERKIKGLSEEERKVSKEHNIIERESALLRKDVSDLTAQESRLVNDLVWLGYKNLLDPMDVEGGIKELSDEYEQVKSRINLRADESYVQVMEGYRGMSTRRNQLESERNSIVSFIEQIVKEKKEMFMDAFGKVDGDIRTTFSKLTGGNARLELENPEDVFAGGVMLLVAFPGKIARESTALSGGEKTIAATVFLLALQSLKPSPFYLMDEVDAHLDAQNTDRLSKILVERSKDNQIIMVTLKDSTVAKATLIYGVYPRQGVSQVVKYRNPGQVPLAQINSSTAEGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRR4</accession>
    <name>A0A075MRR4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative flavin-nucleotide-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_01719</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700488.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRR4"/>
    <dbReference type="STRING" id="1459636.NTE_01719"/>
    <dbReference type="GeneID" id="41597488"/>
    <dbReference type="KEGG" id="nev:NTE_01719"/>
    <dbReference type="eggNOG" id="arCOG00516">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1922684_0_0_2"/>
    <dbReference type="OrthoDB" id="4669at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070967">
        <property type="term" value="F:coenzyme F420 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052019">
        <property type="entry name" value="F420H2_bilvrd_red/Heme_oxyg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35176">
        <property type="entry name" value="HEME OXYGENASE HI_0854-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35176:SF6">
        <property type="entry name" value="HEME OXYGENASE HI_0854-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="PNPOx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine 5'-phosphate oxidase N-terminal" evidence="2">
        <location>
            <begin position="4"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF83780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="132" mass="15199" checksum="04D8973B883A012F" modified="2014-10-29" version="1">MISFTKAEKEFLLANEACRLATCHDNTPHVVPVSYVFEDGAFYFATDLETRKLENLKKNDKVALVVDVYNSSVGNKAVCVQGKAEIIERGKEFARLYRIFHEKFEWVRREPWKEGEAPFVRVVPTTKVSWGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRR8</accession>
    <name>A0A075MRR8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RecA/RadA recombinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_01724</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700491.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRR8"/>
    <dbReference type="STRING" id="1459636.NTE_01724"/>
    <dbReference type="GeneID" id="41597493"/>
    <dbReference type="KEGG" id="nev:NTE_01724"/>
    <dbReference type="eggNOG" id="arCOG00417">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041732_2_0_2"/>
    <dbReference type="OrthoDB" id="17644at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942:SF30">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN DMC1_LIM15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942">
        <property type="entry name" value="RECA/RAD51/RADA DNA STRAND-PAIRING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01874">
        <property type="entry name" value="DNAREPAIRADA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="4">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF83785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="218" mass="23604" checksum="E0E478CA0F77A0FF" modified="2014-10-29" version="1">MFIQTGSQSLDALLGGGIRTGMVTDIYGESGSGKSQLCFSLCASCTKAGFRAFFVDTAGTFRPERVSEMAGTKEALDRITFVRALNTRDQINVVERVRDADARLLVIDTLTSLFSAEYSAGPARHLAVMSHLHDLATFAISTDCAVVVTNMVRNAPTETGKYIQREYLGSSVSIYSHIRMKLALEDPSRGWFHAALLQPSTGTAQFAIIPRGLSDIGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRX0</accession>
    <name>A0A075MRX0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">anthranilate synthase</fullName>
            <ecNumber evidence="3">4.1.3.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NTE_01784</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21732"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="4.1.3.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the anthranilate synthase component I family.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.27" evidence="3"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRX0"/>
    <dbReference type="STRING" id="1459636.NTE_01784"/>
    <dbReference type="KEGG" id="nev:NTE_01784"/>
    <dbReference type="eggNOG" id="arCOG02014">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006493_9_3_2"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="entry name" value="Anthranilate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006805">
        <property type="entry name" value="Anth_synth_I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="AMINOBENZOATE/ANTHRANILATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236:SF9">
        <property type="entry name" value="ANTHRANILATE SYNTHASE COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04715">
        <property type="entry name" value="Anth_synt_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00095">
        <property type="entry name" value="ANTSNTHASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="ADC synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Anthranilate synthase component I N-terminal" evidence="7">
        <location>
            <begin position="17"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate-utilising enzyme C-terminal" evidence="6">
        <location>
            <begin position="186"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF83845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="453" mass="51313" checksum="D6F825F2A7760070" modified="2014-10-29" version="1">MGGKIRIEPLAATEDQFTLFKKLYSSSDRAFILESLIGPKELAEMSVIGFDPEVTVTCDSETFTVERRGRIKKQKVREPLSQLRQLVPEVKDGTFRYIGGAVGYISYDAIRFWESLPVDKRKGKNTFPMMEFGIYTDGILYNHMENRAYYFYLGKSRLKEIECLLSKPPAKSPPFTHTAPRRNMTKEHFAGMVRKAKKYVYDGDTFQVVLAKNIKFGVSGDMLRFYEALREVNPSPYMYFMKMGKRCIIGSSPEMLVRVTKGHVETFPIAGTRPIVEDEKKNEEMRQDLLKDEKELAEHTMLVDLARNDIGRVCRYGTVKVDELMTVKRFSHVQHIVSHVAGNLQESYDSYDALRAVFPAGTVSGAPKVRAMEIINELEPDLRGPYAGALGYFSFNGSCDFAITIRSLFVDGNKAYIQSGAGIVMDSDPEKEWDETEHKANALLSALRKAAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MS20</accession>
    <name>A0A075MS20_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">N5-carboxyaminoimidazole ribonucleotide mutase</fullName>
            <shortName evidence="3 4">N5-CAIR mutase</shortName>
            <ecNumber evidence="3 4">5.4.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">5-(carboxyamino)imidazole ribonucleotide mutase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">purE</name>
        <name evidence="7" type="ORF">NTE_01845</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + H(+) = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate</text>
            <dbReference type="Rhea" id="RHEA:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58730"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="EC" id="5.4.99.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AIR carboxylase family. Class I subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.18" evidence="3 4"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700591.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MS20"/>
    <dbReference type="STRING" id="1459636.NTE_01845"/>
    <dbReference type="GeneID" id="41597609"/>
    <dbReference type="KEGG" id="nev:NTE_01845"/>
    <dbReference type="eggNOG" id="arCOG02464">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094982_2_0_2"/>
    <dbReference type="OrthoDB" id="9473at2157"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00943"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034023">
        <property type="term" value="F:5-(carboxyamino)imidazole ribonucleotide mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1970:FF:000013">
        <property type="entry name" value="Phosphoribosylaminoimidazole carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01929">
        <property type="entry name" value="PurE_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033747">
        <property type="entry name" value="PurE_ClassI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000031">
        <property type="entry name" value="PurE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024694">
        <property type="entry name" value="PurE_prokaryotes"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01162">
        <property type="entry name" value="purE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23046:SF2">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23046">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00731">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001338">
        <property type="entry name" value="AIR_carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01001">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52255">
        <property type="entry name" value="N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1 3 4" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PurE" evidence="6">
        <location>
            <begin position="9"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR001338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001338-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF83905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="182" mass="19147" checksum="8579FD880A4540A8" modified="2014-10-29" version="1">MATATTKKPLVGIIMGSDSDLPVMKEAAEFLDSFGVPNEVTIVSAHRTAKRMYDYAKSAKKRGIEVIIAGAGGAAHLPGMTASLTPLPVIGVPIKTKSLDGIDSLLSIAQMPPGVPVATVAINGAKNAGILACQILAAKHPAIAKRIEKFKQEMEGSVLEKAQSLEDMGIGKYLAKDRRLQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MS73</accession>
    <name>A0A075MS73_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3-dehydroquinate dehydratase</fullName>
            <shortName evidence="4">3-dehydroquinase</shortName>
            <ecNumber evidence="4">4.2.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Type I DHQase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Type I dehydroquinase</fullName>
            <shortName evidence="4">DHQ1</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">aroD</name>
        <name evidence="5" type="ORF">NTE_01955</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>3-dehydroquinate = 3-dehydroshikimate + H2O</text>
            <dbReference type="Rhea" id="RHEA:21096"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="EC" id="4.2.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the type-I 3-dehydroquinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.10" evidence="4"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MS73"/>
    <dbReference type="STRING" id="1459636.NTE_01955"/>
    <dbReference type="KEGG" id="nev:NTE_01955"/>
    <dbReference type="eggNOG" id="arCOG02097">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064444_2_1_2"/>
    <dbReference type="OrthoDB" id="34329at2157"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00086"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046279">
        <property type="term" value="P:3,4-dihydroxybenzoate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00502">
        <property type="entry name" value="DHQase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00214">
        <property type="entry name" value="AroD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001381">
        <property type="entry name" value="DHquinase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050146">
        <property type="entry name" value="Type-I_3-dehydroquinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01093">
        <property type="entry name" value="aroD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43699">
        <property type="entry name" value="3-DEHYDROQUINATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43699:SF1">
        <property type="entry name" value="3-DEHYDROQUINATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01487">
        <property type="entry name" value="DHquinase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="2 4 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0704">Schiff base</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="4">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="4">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>3-dehydroquinate</name>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="34"/>
            <end position="36"/>
        </location>
        <ligand>
            <name>3-dehydroquinate</name>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>3-dehydroquinate</name>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>3-dehydroquinate</name>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>3-dehydroquinate</name>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF84013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="227" mass="24996" checksum="2BB3D4973963A3AB" modified="2014-10-29" version="1">MPLAKICASIAAENASDLVAQAKTAFDLGADFIEARLDFIVAQDQVMQAADGIDKDRAVFTLRSKSQGGRFSGTEQERVKLLRKLAEKRPMLLDVELETLQANDNLADYLELASIPTLVSWHDFEKTPPNDNLADIITEMRLYSNYVKIVTTANSVEDSVRLMSLYENAMLGLHPIIFAMGEAGVMTRVLCALYGAPYTYAAVEKAVAPGQLTIAQMKQLYGSIRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSE9</accession>
    <name>A0A075MSE9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Zn-ribbon RNA-binding protein with a function in translation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01656</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700436.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSE9"/>
    <dbReference type="STRING" id="1459636.NTE_01656"/>
    <dbReference type="GeneID" id="41597431"/>
    <dbReference type="KEGG" id="nev:NTE_01656"/>
    <dbReference type="eggNOG" id="arCOG01989">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_196471_1_0_2"/>
    <dbReference type="OrthoDB" id="35104at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044720">
        <property type="entry name" value="HVO_2753-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011668">
        <property type="entry name" value="HVO_2753-like_ZBP"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011481">
        <property type="entry name" value="PRK14890.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40733:SF1">
        <property type="entry name" value="SMALL ZINC FINGER PROTEIN HVO-2753-LIKE ZINC-BINDING POCKET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40733">
        <property type="entry name" value="ZINC-RIBBON RNA-BINDING PROTEIN INVOLVED IN TRANSLATION-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07754">
        <property type="entry name" value="HVO_2753_ZBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small zinc finger protein HVO-2753-like zinc-binding pocket" evidence="1">
        <location>
            <begin position="10"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="59" mass="6722" checksum="F9B0242E1A23D8CC" modified="2014-10-29" version="1">MSKQLSLPVCTSCSRPIMPNDECVKFYCPNCGYVLMWRCESCREFARPYKCVGCGFEGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSJ8</accession>
    <name>A0A075MSJ8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Iron-sulfur cluster carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NTE_01706</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700477.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSJ8"/>
    <dbReference type="STRING" id="1459636.NTE_01706"/>
    <dbReference type="GeneID" id="41597476"/>
    <dbReference type="KEGG" id="nev:NTE_01706"/>
    <dbReference type="eggNOG" id="arCOG00585">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG01846">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024839_0_0_2"/>
    <dbReference type="OrthoDB" id="8297at2157"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:ATP hydrolysis activity"/>
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        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:iron-sulfur cluster assembly"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Iron-sulfur cluster carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fe-S cluster assembly (FSCA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000808">
        <property type="entry name" value="Mrp-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
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        <property type="entry name" value="NUBPL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961">
        <property type="entry name" value="IRON-SULFUR PROTEIN NUBPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961:SF2">
        <property type="entry name" value="IRON-SULFUR PROTEIN NUBPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="Fe-S cluster assembly (FSCA) domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01215">
        <property type="entry name" value="MRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIP18 family-like" evidence="9">
        <location>
            <begin position="5"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="348"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="349"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="104"/>
            <end position="111"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIF83767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="370" mass="39534" checksum="D800E54FDA486CD1" modified="2014-10-29" version="1">MVTVDQVLGSLKKVVDPELHKDIVSMGMIKDLSINDGKVSFTLELTTPACPFNSDIERDVRAAIAGIGVKDLQMRVTARVMEGRALNLDELLPGVKNIVAVASGKGGVGKTTVSVNLALSLAKTGAKVGLLDADIYGPSVPLMLGLKAQPEVENNKIQPPEVAGVKVISMGFFYEQSQQAGIYRGPIVSGIVKQFLTDVNWGELDYLIIDLPPGTGDAPLTIAQTIPITGILIVTTPQDVAMNVAVKAVGMFHKLNVPIIGVVENMSFLNCPHCNEQIYLFGKGGGKRISDDFNIPFIGEIPLHQHISQGSDTGKPTVLSEPQSFQAQSFEKAAKMIAGRISIIAAEMRAQEEAEGKDPQEGTKDPENKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSK5</accession>
    <name>A0A075MSK5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Amino acid ABC transporter substrate-binding protein, PAAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_02082</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700769.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
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    <dbReference type="STRING" id="1459636.NTE_02082"/>
    <dbReference type="GeneID" id="41597817"/>
    <dbReference type="KEGG" id="nev:NTE_02082"/>
    <dbReference type="eggNOG" id="arCOG01799">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019602_18_2_2"/>
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    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13530">
        <property type="entry name" value="PBP2_peptides_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35936:SF19">
        <property type="entry name" value="AMINO-ACID-BINDING PROTEIN YXEM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35936">
        <property type="entry name" value="MEMBRANE-BOUND LYTIC MUREIN TRANSGLYCOSYLASE F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Solute-binding protein family 3/N-terminal" evidence="2">
        <location>
            <begin position="41"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="3">
        <location>
            <begin position="41"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF84138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="275" mass="29402" checksum="4A9E434E925351CF" modified="2014-10-29" version="1">MKSDTKLWIFMGLGLLSAALLAILPGGISTQERLPDLGGQTIRVAVENAYVPFNFVDNKTGQAAGWDYDTVGEICKRLNCKPEFVQAGWDSMITAVARGEYDVAADGITIKPDRAQLVDFSQGYLTLQQVLLVRAGEDRFHNAKELASGAGLKVGVQAETTNYDVAAGLVKGGSNSGDNGGRLVTYRTFPETVQALVAGDVDAVVIDDVAGQGYVGKDAEKVMVAGKPLTPKEELGFIFPRGSELTKAFDTGLDSMRDDGTLQAINDKWFRGTSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSN0</accession>
    <name>A0A075MSN0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">IPT/TIG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSN0"/>
    <dbReference type="KEGG" id="nev:NTE_02089"/>
    <dbReference type="HOGENOM" id="CLU_795969_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="158"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="348" mass="35156" checksum="5A3D64CB345ABFCA" modified="2014-10-29" version="1">MCKNRSNIHMFGEKKYTILATIVGLAILSAVVVPALIASGNTATAQVTTTTTQPEQQGTDQAQTTIDQQQTQNQTLTNETSTGGNNSFTSSVNISPTADSNAKVTIEGTGLTAKEMNVNQERQDDGTVKITIEGVFAVKEGGVTPEQTGGNETTPAAPSSENETSSSTTTITPSGNETSTNNTAAGAGSINLTPTSGSAGSNIDINGTGFSPNQTFSFTFDGQQLFTNDMTQFATGDFSTAATVPANATSGEHEIVATGDSGESARATFTVMGEESGNATSQSSGNVTSPTTPPSGNETSLTPPPGNTTSPTIPSGNETTTSSPPPATPMPSGNETSGNMTASGAASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSQ3</accession>
    <name>A0A075MSQ3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NADH dehydrogenase subunit A</fullName>
            <ecNumber evidence="8">1.6.5.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NTE_02559</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I subunit 3 family.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.3" evidence="8"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSQ3"/>
    <dbReference type="STRING" id="1459636.NTE_02559"/>
    <dbReference type="KEGG" id="nev:NTE_02559"/>
    <dbReference type="eggNOG" id="arCOG01557">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119549_1_2_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030964">
        <property type="term" value="C:NADH dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1610">
        <property type="entry name" value="NADH:ubiquinone/plastoquinone oxidoreductase, chain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000440">
        <property type="entry name" value="NADH_UbQ/plastoQ_OxRdtase_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038430">
        <property type="entry name" value="NDAH_ubi_oxred_su3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11058">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11058:SF9">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00507">
        <property type="entry name" value="Oxidored_q4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF84606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="127" mass="14195" checksum="C735AC02E49E8E07" modified="2014-10-29" version="1">MGDLAGETAADFTPILYMLGFGLVASVPALILSRLVSPRRRYNPVKFLPMECGQMPTGEGRSHFMMQYYAYILMFVVFDVMSIFLYAWGTALFNIPRTATLPIIAFLGIMFAAMGYALYLAGRKGIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSV6</accession>
    <name>A0A075MSV6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02618</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSV6"/>
    <dbReference type="STRING" id="1459636.NTE_02618"/>
    <dbReference type="GeneID" id="43502655"/>
    <dbReference type="KEGG" id="nev:NTE_02618"/>
    <dbReference type="HOGENOM" id="CLU_2893047_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="62" mass="6618" checksum="F46D6FEDEB69AD4D" modified="2014-10-29" version="1">MELAAMAEIVNRGNPDNQVNPENQGKVAGNPDNQVNPENQERLEIALNKATINAFILSAACG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSY4</accession>
    <name>A0A075MSY4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02648</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701217.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSY4"/>
    <dbReference type="STRING" id="1459636.NTE_02648"/>
    <dbReference type="GeneID" id="41598340"/>
    <dbReference type="KEGG" id="nev:NTE_02648"/>
    <dbReference type="HOGENOM" id="CLU_2021575_0_0_2"/>
    <dbReference type="OrthoDB" id="8956at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="121" mass="13597" checksum="4A66072994BAF804" modified="2014-10-29" version="1">MRSEKDIRLRIDLLEGQASSIAKMLAKAMQEHNEEAVKQYSEKLAQRKGKVEELLWVLGVKTGQSVLDTKAAVPGRQEMTVRDILDLLKEGRIKMDDLALDVQALVRKGALEAKNAMRHTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MT72</accession>
    <name>A0A075MT72_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Isopentenyl-diphosphate delta-isomerase</fullName>
            <shortName evidence="11">IPP isomerase</shortName>
            <ecNumber evidence="11">5.3.3.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Isopentenyl diphosphate:dimethylallyl diphosphate isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Isopentenyl pyrophosphate isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Type 2 isopentenyl diphosphate isomerase</fullName>
            <shortName evidence="11">IDI-2</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">fni</name>
        <name evidence="13" type="ORF">NTE_02264</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>isopentenyl diphosphate = dimethylallyl diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23284"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="5.3.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10 11">Homooctamer. Dimer of tetramers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the IPP isomerase type 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.3.3.2" evidence="11"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226986951.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MT72"/>
    <dbReference type="STRING" id="1459636.NTE_02264"/>
    <dbReference type="GeneID" id="41597979"/>
    <dbReference type="KEGG" id="nev:NTE_02264"/>
    <dbReference type="eggNOG" id="arCOG00613">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065515_1_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004452">
        <property type="term" value="F:isopentenyl-diphosphate delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02811">
        <property type="entry name" value="IDI-2_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00354">
        <property type="entry name" value="Idi_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011179">
        <property type="entry name" value="IPdP_isomerase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02151">
        <property type="entry name" value="IPP_isom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43665">
        <property type="entry name" value="ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43665:SF1">
        <property type="entry name" value="ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003314">
        <property type="entry name" value="IPP_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01240">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 11" id="KW-0288">FMN</keyword>
    <keyword evidence="9 11 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 11" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="6 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0521">NADP</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN-dependent dehydrogenase" evidence="12">
        <location>
            <begin position="185"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="16"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="75"/>
            <end position="77"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="105"/>
            <end position="107"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="283"/>
            <end position="285"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="304"/>
            <end position="305"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIF84318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="362" mass="38653" checksum="1EAC7E6E23FA398F" modified="2014-10-29" version="1">MPDADVPSDIEIIKQRKKDGIDIPLQKDVQARATSTYLEYVKLVHNALPELDYDDIDLSTTFLGHRFSAPLIIDSMTGGTDEATVINGRLGELAEKYGLGMGLGSQRAGLKSEELASTYSVARKNAPNAFLIANIGGAQLAKGLSVDDARKIVRMIRANALVVHLNPLQELVQPEGEPRYRGVYAKIVELVKSMDVPVIVKEVGAGISREVAIKLEMAGVSAINVAGSGGTSWAGVEKLRADMVKDRKKARLGEMFWDWGIPTAASLIEARKAVKVPLVASGGLRNGLEVAKCVALGASMSAMAYPFLKAAAQSREALFEFADSVLAELQSAMFLVGAANVRALASSRYILTGALAQEVSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MT90</accession>
    <name>A0A075MT90_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphate uptake regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_00452</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699487.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MT90"/>
    <dbReference type="STRING" id="1459636.NTE_00452"/>
    <dbReference type="GeneID" id="41596328"/>
    <dbReference type="KEGG" id="nev:NTE_00452"/>
    <dbReference type="eggNOG" id="arCOG00318">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069302_1_0_2"/>
    <dbReference type="OrthoDB" id="40991at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:intracellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045936">
        <property type="term" value="P:negative regulation of phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="entry name" value="Phosphate transport system protein phou homolog 2, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028366">
        <property type="entry name" value="PhoU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026022">
        <property type="entry name" value="PhoU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42930">
        <property type="entry name" value="PHOSPHATE-SPECIFIC TRANSPORT SYSTEM ACCESSORY PROTEIN PHOU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42930:SF2">
        <property type="entry name" value="PHOU DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04014">
        <property type="entry name" value="MazE_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01895">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00966">
        <property type="entry name" value="SpoVT_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="AbrB/MazE/MraZ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109755">
        <property type="entry name" value="PhoU-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="2">
        <location>
            <begin position="25"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF82534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="359" mass="40570" checksum="36DBAF54DAC1C50A" modified="2014-10-29" version="1">MESNVENGGNGKGDGRGEETRKLQYTGGSSYIVSLPKKWIQELGLKQGDHVTILRQGNSTLQIAPASKRITKEQKDATIEVAKDNNPYFIARKLIALYFLGYNVINIVPKDGRLQVEQREVIKNIARRILMGTEIIADSASGITLQVLINLLDLSVDAAFKRMLLIAKSMYRDVMIALRENNAELAEEVIKSDDEVDRFSFYIVRQLKIAIKNEHLLKEIGLEEPRNCLGYRLIAKSVERVADHAAIIAKDIIEMHQPANKEVIEKIDEMCGFALEVLDDACLSMFKRDYEAADRAIEKARKVDEMEKAIIKSISKPKDASEMYRIKLITENVRRVSEYASDIAEIVLNMTVQQTIRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTA2</accession>
    <name>A0A075MTA2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CobQ/CobB/MinD/ParA nucleotide binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699494.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTA2"/>
    <dbReference type="STRING" id="1459636.NTE_00462"/>
    <dbReference type="GeneID" id="41596337"/>
    <dbReference type="KEGG" id="nev:NTE_00462"/>
    <dbReference type="eggNOG" id="arCOG00589">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096711_0_0_2"/>
    <dbReference type="OrthoDB" id="36110at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050678">
        <property type="entry name" value="DNA_Partitioning_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13696">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13696:SF52">
        <property type="entry name" value="PARA FAMILY PROTEIN CT_582"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="4"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="298" mass="33561" checksum="B5B3243FF6CBFA12" modified="2014-10-29" version="1">MTTRSIAFHSYKGGTGKTTLAANLAAKLASEGYNVTLLDLDVYAPSLQVYFDYYPETWLNDLLSGNAKLSEVMVDISSTVSKLVADPGKKTGKLWVGFSNPQKEEIYKMEGGIGKQKNDKIEFLRKFIQVREEIIDRYDCDYIIVDTSPGVRYWSINALALADAIFLTLKFGDLDIEGTRKMATDLYNSFTRFGAKSYLLLNRVAGYCVPESSQAPHLHIHHDKQEMTRMISSLPVTDEQEIGKTLSEQVGMDLISAVPCYCDIQFSRKEFLTVLEHPEHPFAKQLEKLAMSQQIKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTE4</accession>
    <name>A0A075MTE4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0166 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTE4"/>
    <dbReference type="STRING" id="1459636.NTE_02425"/>
    <dbReference type="KEGG" id="nev:NTE_02425"/>
    <dbReference type="eggNOG" id="arCOG04967">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_146749_2_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003793">
        <property type="entry name" value="UPF0166"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35983">
        <property type="entry name" value="UPF0166 PROTEIN TM_0021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35983:SF1">
        <property type="entry name" value="UPF0166 PROTEIN TM_0021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02641">
        <property type="entry name" value="DUF190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="GlnB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="99" mass="11048" checksum="62D3643EAAE533CF" modified="2014-10-29" version="1">MVALAIRIKKNDEFEGKRLERVLLDFFVESGISGSTVWAGVDGFGKRGRSKVQIEGITVNMPLLIEVVDERQRIEPLLAEIKRMVGDNGLVTLHDVDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTF0</accession>
    <name>A0A075MTF0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="STRING" id="1459636.NTE_02010"/>
    <dbReference type="GeneID" id="41597757"/>
    <dbReference type="KEGG" id="nev:NTE_02010"/>
    <dbReference type="HOGENOM" id="CLU_1860617_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="137" mass="15232" checksum="19925E67353F2119" modified="2014-10-29" version="1">MDAKAPAYNIGRWHRPRVYGTIVALYFLVVGAVGFIPLGVVSLMFIPFLGLSILAGIITLRESEGKYVRAFQYGMLIGWLLPSVWVVHLVAGIGGSQPDDATSTPIMVSMWTANILMYIFLYKRYSRSPTKSALFQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTQ4</accession>
    <name>A0A075MTQ4_9ARCH</name>
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        <submittedName>
            <fullName evidence="5">Pyridine nucleotide-disulfide oxidoreductase</fullName>
            <ecNumber evidence="5">1.5.5.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_02474</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.5.5.-" evidence="5"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701082.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTQ4"/>
    <dbReference type="STRING" id="1459636.NTE_02474"/>
    <dbReference type="GeneID" id="41598179"/>
    <dbReference type="KEGG" id="nev:NTE_02474"/>
    <dbReference type="eggNOG" id="arCOG00570">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG01984">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_438458_0_0_2"/>
    <dbReference type="OrthoDB" id="7950at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039651">
        <property type="entry name" value="FixC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43624">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN-QUINONE OXIDOREDUCTASE YDIS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43624:SF2">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN-QUINONE OXIDOREDUCTASE YDIS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF84523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="623" mass="68938" checksum="2B4331ED03AF3F78" modified="2014-10-29" version="1">MTERYDVAVIGGGSAGLAALKKLADLGRQAVLIEAGRQVGTKNVSGGILYSKKPRHGKVHNVEDVYGNFSEAPVERKITKYILHAVSKDKDFAIDLTAAHEYQANFGYSVLLGRLNAWFAKQAAEAAEKAGGGIVSGVHVRSIGWGDEGRAVIETDELEPFEVKAVIAADGVNSEIAVMTGARPKFSPAQLYQGVKVIAKLPEQVLEERFGMGPDEGAAHLFAGDVTLGHIGGGFAYTNRDTLSIGAVYHFDSLMDKPAEPSALVDALLRNPLVSEFVRDEVAVKQEIDRNLPKEEQLRVRFAVSKLVKTWNELRDAYYSPSARKKLVESGKYKSDDEIRSRLESIKNDLQSKYGAKFETDYVELEYSAKLVPDGKRCMMKKPYHKNILFVGDAAGRGVFIGPRIEGLNVGIDDAVRAAESIVRAIDRNNFAPEYMGEYYSQQVEASPYTRDMREIDKDYLKTFLDATKDVPKDIVGQRYGMIFRLISSSAFRGLAVGLANMLGYDKLLPLVESEETYVQVPIEIAERLGKQVTASYTPTIPSVAERVASLKYDDDRQSHIKVTKPESEFMKKMVTLCPTKCYSLEDGKVVLQHEACIECGTCAKETEWRHPRGEKGIVYQYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTT3</accession>
    <name>A0A075MTT3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00614</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699614.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTT3"/>
    <dbReference type="STRING" id="1459636.NTE_00614"/>
    <dbReference type="GeneID" id="41596477"/>
    <dbReference type="KEGG" id="nev:NTE_00614"/>
    <dbReference type="eggNOG" id="arCOG02046">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_703251_0_0_2"/>
    <dbReference type="OrthoDB" id="9050at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048068">
        <property type="entry name" value="LarA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043166">
        <property type="entry name" value="LarA-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33171">
        <property type="entry name" value="LAR_N DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33171:SF17">
        <property type="entry name" value="LARA-LIKE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="377" mass="39068" checksum="12891469CEBBE368" modified="2014-10-29" version="1">MVLDIKFENLSSQVSSTFLAMPDEQAKAALDSIPVTDNMLVLALASSKAAARTIASISDAAKTKGFAPITVDVPAKAAGALRANLASIANATPAVGDPQQTAAAAIPSINRIDYQSLEDRIKKFQSAVVVSQAGFDPLFGFSGAPTALVRALLPEKMAEAFLARKGNVPAPGEQGEPLKIAVSSVQNISAITSVELVANGAGIAGVHTGTVHEAFSKAAEQLKAVATVEADPVRSAVISAGSEAGTHATLAGALYSLWNAVHIVRDGGSAVLLAECREGIGGGALQAFVEGRLKPEQLAAAQYIDGLEHLLYMQELKQKCELGLVSSLPHYYADTKLGLATYAGARDALEKLLVRNGKGHKALVVSDADITLLKPRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTV0</accession>
    <name>A0A075MTV0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03026</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701530.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTV0"/>
    <dbReference type="GeneID" id="41598696"/>
    <dbReference type="KEGG" id="nev:NTE_03026"/>
    <dbReference type="eggNOG" id="arCOG08645">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2177768_0_0_2"/>
    <dbReference type="OrthoDB" id="7214at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="111" mass="12993" checksum="A0585F8850EDE8E6" modified="2014-10-29" version="1">MTKKQVTLDSWVTERLRDRLRRASIIATRTGKPVVLYRHTVEEMDQSAEEEIATVNEQYVVVQVITHGGFIPPNFQQQYVFTFEQFPEYIMKRSNELLALCLDSLDQEIVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTY1</accession>
    <name>A0A075MTY1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03082</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_193354078.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTY1"/>
    <dbReference type="STRING" id="1459636.NTE_03082"/>
    <dbReference type="GeneID" id="59387796"/>
    <dbReference type="KEGG" id="nev:NTE_03082"/>
    <dbReference type="HOGENOM" id="CLU_955171_0_0_2"/>
    <dbReference type="OrthoDB" id="384111at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="361" mass="39681" checksum="FC085414052E152F" modified="2014-10-29" version="1">MSNSIIKNKTAFLSMLIVGAAIASYAFGAPANAFAAGDGGNGGNGGDGGNGGNGGLLNEVVGNGGDGGNGGDGGDGGDGGDSSGSGDGGNGGNGGNGGDGGDGGLLIGNGGNGGNGGNGGNGGDGGDSDADHSDKKQWNNNYDSDNDDNDDNSSKGDEKHWKNSDDSDYGYKKQWKNNYDDDDNDKDHGDKKKHYSNDNEEDDDDHYDRKYKRNYDDNDDKYYGPKHFKYKEKFNDDDDDGYHYSAHWKKKFRYHHDDSYYNNIKIIIHNHYYKDYDAGAFFVHFDTEDYDGNESTKVFKFYDQHFEDHQWDEEGKFYYDEDGNEYQCDDFYMGSVYYDYDGAFYKCDDLTFSEDFEEGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUE0</accession>
    <name>A0A075MUE0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03237</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701698.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUE0"/>
    <dbReference type="STRING" id="1459636.NTE_03237"/>
    <dbReference type="GeneID" id="41598892"/>
    <dbReference type="KEGG" id="nev:NTE_03237"/>
    <dbReference type="HOGENOM" id="CLU_202280_0_0_2"/>
    <dbReference type="OrthoDB" id="11887at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="59" mass="6617" checksum="ABFFEBB476356EFC" modified="2014-10-29" version="1">MDKLESSLIEKQEPFSGPELNIFICENTDGILDPMEQMIYALNELQVSYGSVVILKNAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUF4</accession>
    <name>A0A075MUF4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DNA/RNA helicase, superfamily II</fullName>
            <ecNumber evidence="11">3.6.4.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NTE_02701</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="11"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUF4"/>
    <dbReference type="STRING" id="1459636.NTE_02701"/>
    <dbReference type="KEGG" id="nev:NTE_02701"/>
    <dbReference type="eggNOG" id="arCOG00558">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_1_3_2"/>
    <dbReference type="OrthoDB" id="4631at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140097">
        <property type="term" value="F:catalytic activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00268">
        <property type="entry name" value="DEADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044742">
        <property type="entry name" value="DEAD/DEAH_RhlB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="10">
        <location>
            <begin position="9"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="40"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="228"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="392"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="5">
        <location>
            <begin position="9"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="395"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIF84743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="427" mass="47657" checksum="EC5201C2D628006F" modified="2014-10-29" version="1">MTVPRESAITFNELGLDGKVQRALAENGFEKPFPIQEMAIPLILQGKDVIGQAHTGTGKTAAFGLPLLSKMRNDTRQVQALILVPTRELAVQVTSELIKFSKYAQIWTVSIYGGQSFGVQTGLLKRGAHVVVATPGRLIDHIKRGTIKLDGVKFVVLDEADRMLDMGFIEDIEFILSRLGKSGSSKDRQTLLFSATMSPEILRLAKGHMREGQIREIRLNTKEVGLDNIEQSYLLVGEQQKFNHLTNLIRPHKEQVIVFAATKRRADKLAANLKAGGFRASAIHGDLSQKERDHVMNRFRKGADSVLVATDIAARGIDVPAVGHVINYDVPNEPETYFHRIGRTARAGAEGTAVSLVSPDRFGEFERILRQTKLPISRLNEAMGIEVPAMQQRHPNQHGRQQHPQQHRRSNRNRSGFGGGRRRNWRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUG6</accession>
    <name>A0A075MUG6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Membrane protease subunit, stomatin/prohibitin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_02810</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701356.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUG6"/>
    <dbReference type="STRING" id="1459636.NTE_02810"/>
    <dbReference type="GeneID" id="41598497"/>
    <dbReference type="KEGG" id="nev:NTE_02810"/>
    <dbReference type="eggNOG" id="arCOG01915">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024949_3_3_2"/>
    <dbReference type="OrthoDB" id="10752at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000004">
        <property type="entry name" value="Putative membrane protease family, stomatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043202">
        <property type="entry name" value="Band-7_stomatin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264:SF19">
        <property type="entry name" value="AT06885P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264">
        <property type="entry name" value="BAND 7 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="Band 7" evidence="4">
        <location>
            <begin position="59"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF84850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="325" mass="35852" checksum="4EE4B211382469C2" modified="2014-10-29" version="1">MSTRTFLNFDRLVSQKGSGSQAIAGVVILIVGLAVANVIGSAALAYVVAIIGVAVIISAFLMIIKQYERAVILRLGRFQRQVGPGVQIRIPFADNILVIDVREKVREFTAERMLTKDNVPVTIDAILRYRIIEDRARDAILNVENFNDMIQQVSQTTLRNNIGASYFQDILSKREEVNKHIKEVIAEESRSWGIEVRGVEIRQVAIPKELEDAMSMQAQAEREKNARVTYGESEVLVAKQFEEAAKVYTDNPVAYALRQSNMLYESIKVQGNTIVMVPSESLNSIGFGNLALTQAYLDNIKSVAAAKAATAVADDKSGSEGEKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUS3</accession>
    <name>A0A075MUS3_9ARCH</name>
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        <recommendedName>
            <fullName evidence="1">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701398.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUS3"/>
    <dbReference type="STRING" id="1459636.NTE_02865"/>
    <dbReference type="GeneID" id="41598547"/>
    <dbReference type="KEGG" id="nev:NTE_02865"/>
    <dbReference type="eggNOG" id="arCOG10406">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_198693_0_0_2"/>
    <dbReference type="OrthoDB" id="36578at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="38"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="76" mass="9112" checksum="7D659F2EC7BE4463" modified="2014-10-29" version="1">MAGFFFTAKHECEKCGKKFRKVEEFMQHQQVAHENKQYVCEKCGMGFDGMEQMRDHAKKFHSYNRMLDDRKKKSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUT7</accession>
    <name>A0A075MUT7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zonular occludens toxin (Zot)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03398</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701839.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUT7"/>
    <dbReference type="STRING" id="1459636.NTE_03398"/>
    <dbReference type="GeneID" id="41599044"/>
    <dbReference type="KEGG" id="nev:NTE_03398"/>
    <dbReference type="HOGENOM" id="CLU_1187739_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="233" mass="27187" checksum="5207EBC65EEAC8FC" modified="2014-10-29" version="1">MAIDYQDHFNFKWEVGTENSVVIGAHWQGKTHLAANLIARSILGAYPLWAWDYHGKLRKELLSRHLTPQQQALVYHGTCKRVEMIRKGTNFVVPLDLGIRHFDEFCNLVNRQANMHVMIDEAHNYSSAHRILPSYERLVRDKGNQNVSYTAIFQRPAENHKSIISNATHLFIFKLPLHTDVDYLRKWVGAEVELLLQPEFRKFYEKEPELPNRSFIYKDTRASRPVVVRGGLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUX2</accession>
    <name>A0A075MUX2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987177.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUX2"/>
    <dbReference type="STRING" id="1459636.NTE_01020"/>
    <dbReference type="GeneID" id="41596844"/>
    <dbReference type="KEGG" id="nev:NTE_01020"/>
    <dbReference type="eggNOG" id="arCOG08662">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_182705_1_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="88" mass="9829" checksum="62CB2ED0AEA6A9E9" modified="2014-10-29" version="1">MLNIVTQWIILLAAHSSLMSCRGICEDYRATKTRGLGRYASGQKRCQICDLFIMCDGNVCPCCGYRLRTKPRGQKYKQRIRAAAGAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUX3</accession>
    <name>A0A075MUX3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4396 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_02417</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701037.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUX3"/>
    <dbReference type="STRING" id="1459636.NTE_02417"/>
    <dbReference type="GeneID" id="41598127"/>
    <dbReference type="KEGG" id="nev:NTE_02417"/>
    <dbReference type="HOGENOM" id="CLU_100611_0_0_2"/>
    <dbReference type="OrthoDB" id="10425at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025509">
        <property type="entry name" value="DUF4396"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14342">
        <property type="entry name" value="DUF4396"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4396" evidence="2">
        <location>
            <begin position="22"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF84467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="161" mass="17319" checksum="0E42CC9491A9DC87" modified="2014-10-29" version="1">MQEHNDKDAHPHHGGGSLRWATAKHALRCLIGCNIGEGIGAAVGFALGWDVTSTLVLAVALAFAVGYAFTMIPMLRTMPWRQAAKVTVIGDTASISAMELTENLLAFAIPGFMMASLADAMFWIGMGIILPAGFAVSYPAMYWAMKREQKEGGSMMQAHHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUY9</accession>
    <name>A0A075MUY9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02942</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701459.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUY9"/>
    <dbReference type="GeneID" id="41598620"/>
    <dbReference type="KEGG" id="nev:NTE_02942"/>
    <dbReference type="HOGENOM" id="CLU_800774_0_0_2"/>
    <dbReference type="OrthoDB" id="11385at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="346" mass="39781" checksum="0BB2F9B148FA40B8" modified="2014-10-29" version="1">MQKGVGEERQQGLSSKKPSLKHLSRKQKVADSAPSGKNYLDFSQISALDIKAKKLCTLQGKDFIEGLDELSRFLAAVDPAQSALFQAIDQKGQDFATYFFAAYSDTRNVRVSLRIYNTIKSLVRYIVLMDRYYEIGNRKYKRMADELLRSVKADSEGYLKYAIHFSFAQCWPFWDSEKMMKERMLNGFNFSYKEIRYHNMFKSSDAPTIYGRVLDSELKNYNPNVSLVLHYNQALQDIQDDLDDLEEDLYDKLPNIFILGTVESIPFSTLAANPDSIREAVVKSKSLDKILELAREYESSVEGILLPSQYNFLKDLAHGYAKKLYESIRVCKEKYGMLQVADTTVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MV08</accession>
    <name>A0A075MV08_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Di-/tricarboxylate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NTE_03463</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701888.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MV08"/>
    <dbReference type="STRING" id="1459636.NTE_03463"/>
    <dbReference type="GeneID" id="41599097"/>
    <dbReference type="KEGG" id="nev:NTE_03463"/>
    <dbReference type="eggNOG" id="arCOG00238">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005170_0_0_2"/>
    <dbReference type="OrthoDB" id="19068at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008514">
        <property type="term" value="F:organic anion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905039">
        <property type="term" value="P:carboxylic acid transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001898">
        <property type="entry name" value="SLC13A/DASS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283:SF82">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00939">
        <property type="entry name" value="Na_sulph_symp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="329"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="415"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="460"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="486"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="551"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="188"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF85491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="570" mass="60098" checksum="1C563E21D57F01B1" modified="2014-10-29" version="1">MSLDILGGHKAWFVKKENIGLILGPLLFIAIILIPAPQSMAKAASDKSLPAFAPQLALGTMIWMVVWWVTECAPLGITGLIAPLVFVISGILTIQNAVQNFADPIIWIFIAGFVLAAAFQRSGLDTRIAYSLALLYRGSNPRIATFFVACLPVFLLTMTGSITASTTIVFPFLVAFMNILNIPVRSNDGRNKGGTDDDNDAVDASLTSGSLPSSRGEYKQQKRSNYAEASFLSLGQAASAGAMLLLISTAPNLIAKATVEEFVSAEGGQTISFTDWFVIGTPHAIMGLLVSWFIIFLMIKPEIKSLPATRSQFKARLKSMGKMQRQEKAVLAILIAAMFLWTVPSLLRSSSEASASLAGDSGSVFSNLVAAFAKNMTEAVPALMIIVAVALVRVGRNRPPLLKWEEMTKAVDWNIVLLFGGGLALGMGIEASGLADWIGLQLSSSSLIAGDPAAAAANNNVPWIVFAISAIMAFAISYAASNTASAVITCPIAATLAIGAGVNPVPPIIAAGLACSISTAIPSTTPPMAIIYSSRAVRISGMLKTGIVSDFVRLVLLILLGPPLISLVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MV09</accession>
    <name>A0A075MV09_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10 11">Phosphoenolpyruvate carboxykinase (ATP)</fullName>
            <shortName evidence="10">PCK</shortName>
            <shortName evidence="10">PEP carboxykinase</shortName>
            <shortName evidence="10">PEPCK</shortName>
            <ecNumber evidence="3 10 11">4.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">pckA</name>
        <name evidence="12" type="ORF">NTE_02447</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>oxaloacetate + ATP = phosphoenolpyruvate + ADP + CO2</text>
            <dbReference type="Rhea" id="RHEA:18617"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.1.1.49"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="10">Binds 1 Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.49" evidence="3 10 11"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MV09"/>
    <dbReference type="STRING" id="1459636.NTE_02447"/>
    <dbReference type="KEGG" id="nev:NTE_02447"/>
    <dbReference type="eggNOG" id="arCOG06073">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018247_0_1_2"/>
    <dbReference type="OrthoDB" id="192074at2157"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004612">
        <property type="term" value="F:phosphoenolpyruvate carboxykinase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00484">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.8.10:FF:000001">
        <property type="entry name" value="Phosphoenolpyruvate carboxykinase (ATP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.449.10">
        <property type="entry name" value="Phosphoenolpyruvate Carboxykinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.8.10">
        <property type="entry name" value="Phosphoenolpyruvate Carboxykinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00453">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001272">
        <property type="entry name" value="PEP_carboxykinase_ATP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013035">
        <property type="entry name" value="PEP_carboxykinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008210">
        <property type="entry name" value="PEP_carboxykinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015994">
        <property type="entry name" value="PEPCK_ATP_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00224">
        <property type="entry name" value="pckA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006820">
        <property type="entry name" value="PRK09344.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006821">
        <property type="entry name" value="PRK09344.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30031:SF0">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYKINASE (ATP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30031">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYKINASE ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01293">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006294">
        <property type="entry name" value="PEP_crbxkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68923">
        <property type="entry name" value="PEP carboxykinase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53795">
        <property type="entry name" value="PEP carboxykinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00532">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="4 10" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-0464">Manganese</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="10">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="213"/>
            <end position="221"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="418"/>
            <end position="419"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="424"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="NCBIfam" id="TIGR00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIF84497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="508" mass="56576" checksum="4FB811A45BE97066" modified="2014-10-29" version="1">MNLSVPCLLEHALRLKEGRFASNGAFCVETGRFTGRSPEDRYIVLDDVTRDTVNWNHINRPISPDKFEQIFFGMGSYMSHKDLFVFDGFVGANPENGRLGVRVITDRAWQCLFASQLFIKPSKEELESFKPDFLLLSMNDFKAMPLVDGTRSETFIVLNLSRHIVLIGSTSYAGEIKKAMFSAMNYFLPEEGVLPMHCAANVDNSGQVALFFGLSGTGKTTLSADPGRSLIGDDEHGWSETGVFNFEGGCYAKCINLKEENEPQIWNAIKFGSIMENVVIKDDTREPDYSDARLTENTRVAYPLDHIPGSVKPSIGGHPDVIIFLTADAFGVMPPISKLSIEGAMYHFLSGYTSKLAGTERGITEPKETFSECFGAPFMPRHPLVYARLLGEKIKKHGSRVYLVNTGWIGGPYGIGKRIELKYTRAMVTAALDGTLDSIQGQKDEIFNLDVPLSCPGVPPEVLDQKRMWKEKLEYEKQAKKLASMFIKNFEKFGDVAKRLSVAGPQIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MV58</accession>
    <name>A0A075MV58_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zn-dependent alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_03106</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701588.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MV58"/>
    <dbReference type="STRING" id="1459636.NTE_03106"/>
    <dbReference type="GeneID" id="41598766"/>
    <dbReference type="KEGG" id="nev:NTE_03106"/>
    <dbReference type="eggNOG" id="arCOG01458">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_3_4_2"/>
    <dbReference type="OrthoDB" id="8709at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051603">
        <property type="entry name" value="Zinc-ADH_QOR/CCCR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44154">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44154:SF1">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="12"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF85140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="352" mass="38552" checksum="1D06F1E415A71421" modified="2014-10-29" version="1">MKAAVFREYNKDPTKVVKIEDIDVPKLKPNEVLIKVESASYNYNDLWAIWGEPVKTPLPHISGSDVAGTIVEVGSDVLKLKVGDRVVSHSNMSCRVCDACTSGREYDCNDRQIWGFQTGPLWGGFAQYTRLPEVNVVKIADNVSFENAAAVSMVGMTSWHMLVGRAKIKPGQVVLIMGGGSGVGMVGIQIAKLYNCTVIATAGKKDKMDKCLELGADYVVNHREADWYKKVRAINKELNQPGVDVVFEHIGKSVFPQEVGLLKMGGTLVATGATTGYDSTIDLRYLFFRGTNLLGSTQGTKAELEDVVYWVSKGKIKPVIDTVLPFSDMVKGHVMMAEAQQFGKILTTPQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MV64</accession>
    <name>A0A075MV64_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SPFH domain, Band 7 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_03513</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_264357926.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MV64"/>
    <dbReference type="STRING" id="1459636.NTE_03513"/>
    <dbReference type="GeneID" id="41599134"/>
    <dbReference type="KEGG" id="nev:NTE_03513"/>
    <dbReference type="eggNOG" id="arCOG01915">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047969_1_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03401">
        <property type="entry name" value="SPFH_prohibitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000163">
        <property type="entry name" value="Prohibitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222">
        <property type="entry name" value="PROHIBITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222:SF0">
        <property type="entry name" value="PROHIBITIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00679">
        <property type="entry name" value="PROHIBITIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="3">
        <location>
            <begin position="2"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="221"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="120"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF85541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="246" mass="27051" checksum="85A03F9E44FF4B1A" modified="2014-10-29" version="1">MDVRTQKTSEVAASASKDLQDVRTEVALNYHLNPDSAQIVYQQLGFGYAERVISPAIQESVKQVTARFNAEELITKRETVKTEIEEQIKQRLAIYNIVVETISITEFKFSEQFTKAVESKVEAEQRALQASNELRRIQIEAQQAEAKAIGEQKANVARAEGIRQSNILHAEGESQAIQIIDQKLRESPSYLEWLKTQKWDGKLPFVVGGGDGGATPFIQIPTGGSASATDEDGGGEGAIQNATRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVE4</accession>
    <name>A0A075MVE4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_01151</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700021.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVE4"/>
    <dbReference type="STRING" id="1459636.NTE_01151"/>
    <dbReference type="GeneID" id="41596963"/>
    <dbReference type="KEGG" id="nev:NTE_01151"/>
    <dbReference type="eggNOG" id="arCOG06256">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049413_6_1_2"/>
    <dbReference type="OrthoDB" id="10258at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF17">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="3">
        <location>
            <begin position="24"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF83224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="222" mass="24392" checksum="29CEF7B413384980" modified="2014-10-29" version="1">MSRPDLGFIHRFVPPSATRKEVKDKRQIITLLLLHGTGGNEDDMIPLGQALAPTSATAILSPRGKVLENGVAPRFFKRLEEGVFDMQDLKFRTHELADFVEAASKAYGFDLKHIVAVGYSNGANIATSIMLLRPKTLSAAILFRPMVPLVPDMTPDLSDVNVFISAGLHDRIVARKETEQLVNLLSKAGAKVVLHWHEGGHELGREEIVAAKDWLATNITPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVI1</accession>
    <name>A0A075MVI1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Glutamine synthetase, type I</fullName>
            <ecNumber evidence="13">6.3.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">NTE_02629</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SR1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="7">Binds 2 Mg(2+) ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9 10">Belongs to the glutamine synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="13"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVI1"/>
    <dbReference type="STRING" id="1459636.NTE_02629"/>
    <dbReference type="KEGG" id="nev:NTE_02629"/>
    <dbReference type="eggNOG" id="arCOG01909">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017290_1_2_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamine synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019740">
        <property type="term" value="P:nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
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        <property type="entry name" value="Gln_synt_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
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    </dbReference>
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        <property type="entry name" value="Gln_synth_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027302">
        <property type="entry name" value="Gln_synth_N_conserv_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00653">
        <property type="entry name" value="GlnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43407">
        <property type="entry name" value="GLUTAMINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LENGSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00180">
        <property type="entry name" value="GLNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51986">
        <property type="entry name" value="GS_BETA_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51987">
        <property type="entry name" value="GS_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GS beta-grasp" evidence="11">
        <location>
            <begin position="44"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="GS catalytic" evidence="12">
        <location>
            <begin position="137"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="291"/>
            <end position="292"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="365"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="377"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="397"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
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            <position position="399"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="O-AMP-tyrosine" evidence="8">
        <location>
            <position position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
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        <source>
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        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIF84672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="508" mass="56760" checksum="ED9C1479A12521E8" modified="2014-10-29" version="1">MIIVNGLISYKRHIYGIDMSFRDASSLEELQQKNNSSSGPDDITSAEFLQLRYTDVPGRFLAKYVFSGNKSLREYFKSGVGLDGSSVRGFATIDESDLLLVPDRSTLRRLPLPDFNVATVIADVYRGFGRGRLPRDPRHVSQCVEERLAYDGLACQVGPEVECFIFDDMVFSGGHEAKIVSVEDEGQSKYPLRRKGGYDAPPFQDSLMEFRFEVADMLEKYYSIEVTNLNHEVASSGQIEINFLHDTLTKAADNVQVYKDVVRNVAKKHNKVANFMPKPIFDESDRRAGDNGSGMHVSVSLWTKSHAAKDSNNHRNIFYDPSDEYAEFSQAGRYFIGGLLDHAASLACLVAPTVNSYYRMVPGFEAPVYAAWSRGNRSAIIRVPVNERGSSGSKRIEFRAPDPSANPYLAFSAVVSAGLDGIKKKTDPGDPINENIYKMTDDQRRSLGIKPLPGSLQDSIAALESDLGYLKSCFSDELLETYLSLKEKEVEEAGDCSKERQFRMYYDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVN2</accession>
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        </submittedName>
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        <name evidence="1" type="ORF">NTE_01290</name>
    </gene>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
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        <property type="entry name" value="Dimeric_a/b-barrel"/>
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        <property type="entry name" value="DUF1428"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="134" mass="15126" checksum="DBEFD7ED922A99E9" modified="2014-10-29" version="1">MNNSTTEPAREIEIGSYVALTFWRAPKKNRDAVVQVGRQNDQIWRKHGMLRSETFLLGTRDVPTGCKSIANILSAADEGEDLWVLQQFFRDRDHADKVLSNVIKDESINKVVKEFYGEIAQGQSLVTGGFSRIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVP2</accession>
    <name>A0A075MVP2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cell division protein 48 (CDC48), domain 2/Cell division protein 48 (CDC48), N-terminal domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_03286</name>
    </gene>
    <organism evidence="5 6">
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            <taxon>Nitrososphaerales</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="AAA family ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Cdc48_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003338">
        <property type="entry name" value="CDC4_N-term_subdom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02933">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02359">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01072">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01073">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CDC48 N-terminal subdomain" evidence="4">
        <location>
            <begin position="15"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="CDC48" evidence="3">
        <location>
            <begin position="113"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF85315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="275" mass="30819" checksum="0B537B393B131A66" modified="2014-10-29" version="1">MLSSSNTEGDNEKAYLTVHEGYTRDIGRGVARIDRESMDSAGIAEGDIIQIIGKRKTVARCHALYPSDEGRRKIIRIDGVIRANSDTKIGETVRVRKIIAPSASRVVVRPRESIPPLDEHYLTDALNGVPLVQGDNFLVPYFGGRLAFQAVSTEPQGAIVVDQQTIFFIANGESLIRFTITDLVRQEERGRSYLVLKFTLQGFGVSEAGEFQRRIEEDSDLAKTCNRHLDVITKEVAKKNDNPSTTIDIVTEANRKDILREIKFDIIKKMMNLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MW73</accession>
    <name>A0A075MW73_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_03472</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MW73"/>
    <dbReference type="KEGG" id="nev:NTE_03472"/>
    <dbReference type="HOGENOM" id="CLU_851570_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF85500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="350" mass="36599" checksum="79F0A11F3B63329F" modified="2014-10-29" version="1">MLILSSATIVIGPFNVAYAHTFQGGESAEFLTMVQVIKTETALAGNNTGSADKDIAIDHIEHASEALTNSTLKEIAERNQRLATDLPASIEQLRMSISSGVSASQIEQDVKTISDLLDETVQVRIEKSQLTNSTVQAVIVANLVNEALEHYGEAIGYEGNMTDMSSMAGMTSSMSGNESSTTSSSMSMNTGSSSNSGSTQGMNSSNISSSSGSSGMSMSKAVIVSEANYQSAKAFAQKAWGLYQQIKPQATDGGSGNSVEKLDKSFPAFLSAIESKASAMDIMSIAHLQIHPNLMTAYNLQVVPEFPIPLLISLPALAAAVLYGRFRMNAKNSGGDGGSAAGNGGSPKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWA6</accession>
    <name>A0A075MWA6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Universal stress protein UspA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_02899</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWA6"/>
    <dbReference type="STRING" id="1459636.NTE_02899"/>
    <dbReference type="KEGG" id="nev:NTE_02899"/>
    <dbReference type="eggNOG" id="arCOG02053">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049301_16_5_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00293">
        <property type="entry name" value="USP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46268">
        <property type="entry name" value="STRESS RESPONSE PROTEIN NHAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46268:SF6">
        <property type="entry name" value="UNIVERSAL STRESS PROTEIN UP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006276">
        <property type="entry name" value="UspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UspA" evidence="2">
        <location>
            <begin position="11"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF84937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="159" mass="16976" checksum="4FD757E592E99497" modified="2014-10-29" version="1">MIMTGSEVSVKKILVPVDGSPVSNKAAQYAMHLAKMEGAKLVIMHVVENVKQGGAIGLQARYGNVRLVEGFQRARIKSAEEWMSKIMDNAAGQGISAKTEILSDDGTHEVGVITEYAKKNGADLIVMGSRGQSTFKKLLVGSVTNAVINHSPCPVLVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWJ6</accession>
    <name>A0A075MWJ6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Putative [LysW]-lysine/[LysW]-ornithine hydrolase</fullName>
            <ecNumber evidence="8">3.5.1.130</ecNumber>
            <ecNumber evidence="8">3.5.1.132</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">lysK</name>
        <name evidence="10" type="ORF">NTE_01581</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the release of L-lysine from [LysW]-gamma-L-lysine and the release of L-ornithine from [LysW]-L-ornithine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>[amino-group carrier protein]-C-terminal-gamma-(L-lysyl)-L-glutamate + H2O = [amino-group carrier protein]-C-terminal-L-glutamate + L-lysine</text>
            <dbReference type="Rhea" id="RHEA:48684"/>
            <dbReference type="Rhea" id="RHEA-COMP:9693"/>
            <dbReference type="Rhea" id="RHEA-COMP:9715"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:78525"/>
            <dbReference type="ChEBI" id="CHEBI:78526"/>
            <dbReference type="EC" id="3.5.1.130"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>[amino-group carrier protein]-C-terminal-gamma-(L-ornithyl)-L-glutamate + H2O = [amino-group carrier protein]-C-terminal-L-glutamate + L-ornithine</text>
            <dbReference type="Rhea" id="RHEA:52676"/>
            <dbReference type="Rhea" id="RHEA-COMP:9693"/>
            <dbReference type="Rhea" id="RHEA-COMP:13328"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:78525"/>
            <dbReference type="ChEBI" id="CHEBI:136763"/>
            <dbReference type="EC" id="3.5.1.132"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <text evidence="8">Binds 2 Zn(2+) or Co(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis; L-arginine biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (Thermus route): step 5/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase M20A family. LysK subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.130" evidence="8"/>
    <dbReference type="EC" id="3.5.1.132" evidence="8"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWJ6"/>
    <dbReference type="STRING" id="1459636.NTE_01581"/>
    <dbReference type="KEGG" id="nev:NTE_01581"/>
    <dbReference type="eggNOG" id="arCOG01107">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021802_2_0_2"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER00039"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:L-arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01120">
        <property type="entry name" value="LysK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010175">
        <property type="entry name" value="LysK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050072">
        <property type="entry name" value="Peptidase_M20A"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01902">
        <property type="entry name" value="dapE-lys-deAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43808:SF28">
        <property type="entry name" value="[LYSW]-LYSINE_[LYSW]-ORNITHINE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43808">
        <property type="entry name" value="ACETYLORNITHINE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0170">Cobalt</keyword>
    <keyword evidence="1 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="9">
        <location>
            <begin position="158"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIF83644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="380" mass="41222" checksum="EB68654957E351C2" modified="2014-10-29" version="1">MVSPSYAVELLQKALELYTPSRSEAALANMIKDKCTNELGFEQVSIDSVGNVIASKGTGEPRILLCGHMDTVPGQVPVRIEDGYLYGRGASDAKAPLIAMLLAASQFPKQSGTVIFAGVVDEEGNATGVKNLVKSKIGLDYAMFGEPSGIDNITIAYKGRLAIRLTCDVGDSAHASAPWLARNSIEEMHDFWRAIKAEIEKVGTADTKANSISCTLTEISGGSSHNVTPQKCKITIDMRIPTITTCQNVLDTVDNVITRVAKEKGVKATYRIEDRTDPFEADHSSALVRALSLGILDVRKKRPVLLRKTGTGDMNVLGNTFKIPVVTYGPGDPHASHTADERVNVEEYVNSIEVFSRALFHMSRIHHIRKQQNGDGKKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWN7</accession>
    <name>A0A075MWN7_9ARCH</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83679.1"/>
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    </dbReference>
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    <dbReference type="GeneID" id="41597394"/>
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    <dbReference type="eggNOG" id="arCOG08750">
        <property type="taxonomic scope" value="Archaea"/>
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        <property type="component" value="Chromosome"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="103" mass="11085" checksum="BEAB16B9D44DAD18" modified="2014-10-29" version="1">MNWMAQTMMWIMVSLGISIALNFLLGPYLGWLTIIPIIGVFLAMSYVIRRRQMARMGMGGQGGGFGGMLGGGGGINYVCIACGHKFKGGACPRCGSKMRRADF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWQ4</accession>
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        <name evidence="1" type="ORF">NTE_03042</name>
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    <organism evidence="1 2">
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AIF85077.1"/>
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    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="68225781"/>
    <dbReference type="KEGG" id="nev:NTE_03042"/>
    <dbReference type="HOGENOM" id="CLU_2856921_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="64" mass="7837" checksum="A82C5F1D30F62A2A" modified="2014-10-29" version="1">MSCIFRKKEIHPTSRPRNLIREIHLTRVFLYADVFKDKKPRSFDEVFEMEKQVEDDTATYNRIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWV9</accession>
    <name>A0A075MWV9_9ARCH</name>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">NTE_01693</name>
    </gene>
    <organism evidence="1 2">
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWV9"/>
    <dbReference type="GeneID" id="43502618"/>
    <dbReference type="KEGG" id="nev:NTE_01693"/>
    <dbReference type="HOGENOM" id="CLU_3020784_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="55" mass="6131" checksum="9E79018CA5EBFEFE" modified="2014-10-29" version="1">MQVADSFAIEEISVKNYNNKTREGQSCRTFIPHDPITAPFAITFSAYPLTFCTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWZ2</accession>
    <name>A0A075MWZ2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphosulfolactate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphosulfolactate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701611.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWZ2"/>
    <dbReference type="STRING" id="1459636.NTE_03133"/>
    <dbReference type="GeneID" id="41598793"/>
    <dbReference type="KEGG" id="nev:NTE_03133"/>
    <dbReference type="eggNOG" id="arCOG00394">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG04896">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062679_2_0_2"/>
    <dbReference type="OrthoDB" id="6405at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003830">
        <property type="entry name" value="ComA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036112">
        <property type="entry name" value="ComA_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48413">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48413:SF1">
        <property type="entry name" value="PROTEIN HEAT-STRESS-ASSOCIATED 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02679">
        <property type="entry name" value="ComA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102110">
        <property type="entry name" value="(2r)-phospho-3-sulfolactate synthase ComA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="328" mass="36747" checksum="49F1A835DEBF8AF7" modified="2014-10-29" version="1">MLESYVKNRVDVKKPRKEGRTYVIDKLQGLDKENFEALAPFIDAVKIYGVLPLLLSESVLQKKIKFYQDLGVKVSTGSTISEYMVSENAFDKFVGDAARVGFNIIEIGENGIDLTFEQKKKLTDTILARNLDFQWKVGKKDPRHQISIDATIAKVEEAVKLGSDKVVLEANEGFSVGIYDEKGAVRWNAVGALTAKYPPTTFIFEAPLEHQQSALIAEFGQRVNLAEIHIDAVSSIESQRRGFPSKASFGVSYLRKDPEGGPAAKFVYFIIKSKHPIDQVELMEMSRLPRRTVQSAVEDLKSQGLIIERSSLDDARKKMYAPVQSVWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MXH5</accession>
    <name>A0A075MXH5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03288</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701744.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MXH5"/>
    <dbReference type="GeneID" id="41598942"/>
    <dbReference type="KEGG" id="nev:NTE_03288"/>
    <dbReference type="HOGENOM" id="CLU_1444625_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="187" mass="20040" checksum="DCBA8C185447997C" modified="2014-10-29" version="1">MMSLIAAAIVVSVLGVATADTTTRDAVARKVDLSTVRITEVGKDTYTTKLLSNMNAAATAQVQNVAQIDTANIGKQSAFLFSADWIKANKNDESFKQFLKTAMDKRGVVMAVGNNTDILGSALESAGVHGGFGTGGADTPVVAYKITDYTDVAGNPRQLYHEYHSGTPEGYYYDDSDMQKLAEWLTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MY27</accession>
    <name>A0A075MY27_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Plastocyanin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_03534</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701936.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MY27"/>
    <dbReference type="STRING" id="1459636.NTE_03534"/>
    <dbReference type="GeneID" id="41599152"/>
    <dbReference type="KEGG" id="nev:NTE_03534"/>
    <dbReference type="eggNOG" id="arCOG02926">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_867690_0_0_2"/>
    <dbReference type="OrthoDB" id="4392at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000923">
        <property type="entry name" value="BlueCu_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052721">
        <property type="entry name" value="ET_Amicyanin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36507">
        <property type="entry name" value="BLL1555 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36507:SF1">
        <property type="entry name" value="BLL1555 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00127">
        <property type="entry name" value="Copper-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Blue (type 1) copper" evidence="4">
        <location>
            <begin position="235"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="216"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF85562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="320" mass="35773" checksum="A8881B72A06833C5" modified="2014-10-29" version="1">MVLAFAVLGALLYVSAIQTSGRIAHDSKAIPTEPKISQLQAIETAEKHLQSKVKGVQEIRLEFPLYNFSMQRYTSDPSYVEYIEKNNLRHGSLLSQVKEHPELLNLPLYFVHANGTLYSVNATGHTFEKVCEEPSFRCPLPVLAINASRDKLVYRVYITWPKPSIPTNEALYLVNAETGEITMNFVDAVLNRLPTPNVNFDNRTISQLYNELANPPQTTNIDIEQGASDQGANKGYSPKEIRVVLGTNNRVVWTNRDTVPESVVSDSGYIDELTGKKFESGLILPGGTFEFTFTKEGEYSYHAEPHPWMTGKISVVEGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MY29</accession>
    <name>A0A075MY29_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histidine kinase N-terminal 7TM region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MY29"/>
    <dbReference type="STRING" id="1459636.NTE_02129"/>
    <dbReference type="KEGG" id="nev:NTE_02129"/>
    <dbReference type="eggNOG" id="arCOG10526">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1003322_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="259" mass="27245" checksum="04D79D9618E4237F" modified="2014-10-29" version="1">MAAIAASIALAGDKSDLARDMSINATAIAAAGSSVFAVRAQKVPAGKRLVGFLAAALFSWLAAELAWSYMLFVLDIDPYPSAADLLYLAGYGFAAYVVFSLYRTLAARTQETRMVLLVGAVTVEALFLNLFLIQIVESAMGFGTAGNNNDPVVLAISVAYPLLDGALIVPAAVIVVGYRSALIDKFSIIMLVAALISIAVADTGFGYVALQDRSAEGAEWDLLYCLSYLCFAGAMLNTYSRLKGAKTLSVKEQTAAGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MYM5</accession>
    <name>A0A075MYM5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02311</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700947.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MYM5"/>
    <dbReference type="GeneID" id="41598026"/>
    <dbReference type="KEGG" id="nev:NTE_02311"/>
    <dbReference type="HOGENOM" id="CLU_2911321_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="61" mass="6820" checksum="B291AD9DCDB2123A" modified="2014-10-29" version="1">MPKSSKADTIAAVLEAHMHSMRLMHDVIVENNKILKDISKKLDAVNDDLHALVRNLETKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MZ01</accession>
    <name>A0A075MZ01_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02434</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701051.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MZ01"/>
    <dbReference type="STRING" id="1459636.NTE_02434"/>
    <dbReference type="GeneID" id="41598142"/>
    <dbReference type="KEGG" id="nev:NTE_02434"/>
    <dbReference type="HOGENOM" id="CLU_1493024_0_0_2"/>
    <dbReference type="OrthoDB" id="11453at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="180" mass="20151" checksum="35C502C0038E3AE3" modified="2014-10-29" version="1">MDPKSQSAAEQLISQEVDAVGASPARVKGNGCAACHVLFTLVDKMGLSETDAADLLSQVLTDRPALNDRFIEMVENIHMKQRMAGVAFAIKTREAKDRYIDSQFKNSLDELLGDAANFGAELAMRKLVMTHISLQIAQNLGIDYHAATEELYYYMRKRDEETHSQLMQLVRSMIERGARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MZE1</accession>
    <name>A0A075MZE1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CRISPR-associated endoribonuclease Cas2</fullName>
            <ecNumber evidence="8">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cas2</name>
        <name evidence="9" type="ORF">NTE_02570</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer, forms a heterotetramer with a Cas1 homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="8"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701154.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MZE1"/>
    <dbReference type="STRING" id="1459636.NTE_02570"/>
    <dbReference type="GeneID" id="41598265"/>
    <dbReference type="KEGG" id="nev:NTE_02570"/>
    <dbReference type="eggNOG" id="arCOG04194">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_161124_2_0_2"/>
    <dbReference type="OrthoDB" id="75992at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09725">
        <property type="entry name" value="Cas2_I_II_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01471">
        <property type="entry name" value="Cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021127">
        <property type="entry name" value="CRISPR_associated_Cas2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019199">
        <property type="entry name" value="Virulence_VapD/CRISPR_Cas2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01573">
        <property type="entry name" value="cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34405">
        <property type="entry name" value="CRISPR-ASSOCIATED ENDORIBONUCLEASE CAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34405:SF3">
        <property type="entry name" value="CRISPR-ASSOCIATED ENDORIBONUCLEASE CAS2 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09827">
        <property type="entry name" value="CRISPR_Cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143430">
        <property type="entry name" value="TTP0101/SSO1404-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="4 8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF84614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="99" mass="11272" checksum="BC7B4E798CFF464E" modified="2014-10-29" version="1">MKGNSYYAVYDISDDLVRKNVIRILKNAGFIRIQKSAFCGTLVNQKKKDLLEDIKKVIADERDSFYLILTCEQCFGRISIVGKGFDRQYAAGKRSAEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MZL0</accession>
    <name>A0A075MZL0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Micrococcal nuclease-like nuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02636</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MZL0"/>
    <dbReference type="STRING" id="1459636.NTE_02636"/>
    <dbReference type="KEGG" id="nev:NTE_02636"/>
    <dbReference type="eggNOG" id="arCOG03192">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1080170_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016071">
        <property type="entry name" value="Staphylococal_nuclease_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00565">
        <property type="entry name" value="SNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00318">
        <property type="entry name" value="SNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50199">
        <property type="entry name" value="Staphylococcal nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TNase-like" evidence="1">
        <location>
            <begin position="159"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="272" mass="29640" checksum="D7D1302120D058B0" modified="2014-10-29" version="1">MTCFPRIVLKALFLVVLALAPLPVFALAAAASNDDDYAGVTIDKLLVVPEGGQFEAGRQMSIRVNITSSSQQQGPIFYIVQVQDPDGYTDYLKWEQVAFTGQRTFEFSWTPQKEGRYIIQAFVWDSLSSPKPLSQASAGFLDIAGTTSVAHCVGAAVCFSGTVTKITDGDTIRVNNIAIRLALVNTPERGQPGYKEATDFTRALCPVGSTALVDEDDEQQAGSYDRMVAKVFCGDKVLNAELLNAKHAVILTTFCDKSEFASEPWARQYGCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MZR4</accession>
    <name>A0A075MZR4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02671</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701234.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MZR4"/>
    <dbReference type="STRING" id="1459636.NTE_02671"/>
    <dbReference type="GeneID" id="41598361"/>
    <dbReference type="KEGG" id="nev:NTE_02671"/>
    <dbReference type="HOGENOM" id="CLU_2911662_0_0_2"/>
    <dbReference type="OrthoDB" id="374222at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="64" mass="7202" checksum="C0DA1B17E405666B" modified="2014-10-29" version="1">MEPLMLGFVSLDMTVGMLLGMAASPVMMKGIKVIRQRRRINRMLHEIAEIRRTTTCSSGLNQPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MZV0</accession>
    <name>A0A075MZV0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glutamyl-tRNA(Gln) amidotransferase subunit E</fullName>
            <shortName evidence="6">Glu-ADT subunit E</shortName>
            <ecNumber evidence="6">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">gatE</name>
        <name evidence="8" type="ORF">NTE_02722</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-glutamyl-tRNA(Gln) + L-glutamine + ATP + H2O = L-glutaminyl-tRNA(Gln) + L-glutamate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterodimer of GatD and GatE.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the GatB/GatE family. GatE subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="6"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701280.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MZV0"/>
    <dbReference type="STRING" id="1459636.NTE_02722"/>
    <dbReference type="GeneID" id="41598412"/>
    <dbReference type="KEGG" id="nev:NTE_02722"/>
    <dbReference type="eggNOG" id="arCOG01719">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030702_0_0_2"/>
    <dbReference type="OrthoDB" id="7316at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070681">
        <property type="term" value="P:glutaminyl-tRNAGln biosynthesis via transamidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.30">
        <property type="entry name" value="GAD-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.380">
        <property type="entry name" value="GatB domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00588">
        <property type="entry name" value="GatE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017959">
        <property type="entry name" value="Asn/Gln-tRNA_amidoTrfase_suB/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006075">
        <property type="entry name" value="Asn/Gln-tRNA_Trfase_suB/E_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018027">
        <property type="entry name" value="Asn/Gln_amidotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004115">
        <property type="entry name" value="GAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029351">
        <property type="entry name" value="GAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042114">
        <property type="entry name" value="GatB_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023168">
        <property type="entry name" value="GatB_Yqey_C_2"/>
    </dbReference>
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        <property type="entry name" value="GatE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017958">
        <property type="entry name" value="Gln-tRNA_amidoTrfase_suB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00134">
        <property type="entry name" value="gatE_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003107">
        <property type="entry name" value="PRK04028.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659">
        <property type="entry name" value="GLUTAMYL-TRNA GLN AMIDOTRANSFERASE SUBUNIT B MITOCHONDRIAL AND PROKARYOTIC PET112-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659:SF2">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02938">
        <property type="entry name" value="GAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02934">
        <property type="entry name" value="GatB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02637">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00845">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55261">
        <property type="entry name" value="GAD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="GatB/YqeY motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01234">
        <property type="entry name" value="GATB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 6 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Asn/Gln amidotransferase" evidence="7">
        <location>
            <begin position="485"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF84764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="636" mass="69174" checksum="C0376308B0C92692" modified="2014-10-29" version="1">MTTDLSSLDLKVGFEIHQQLATKSKLFCNCSCAEAETYGRTFVRRLRPTQSELGAYDPAAMFEFSKMRLAEYHASAGTSCLVEADEEPPHEVNPEALETALVFALALHSRVMDEVHVMRKIVIDGSNTSGFQRTMLVASGGYLDVSGKKVGVQSICLEEDASKALGDDKQIKKYGLDRLGVPLVEIALEPVTGKPDEIMQVALTLGRLLRASKRVARGLGSIRQDVNVSILGGAVVEVKGVQQLDQLIKVIEHEATRQHGFVLIAEKLKENKIAKDGIGDRVEDVTDLLSKSQSKVVKKIFEGIRPVFRAIRVRGFAGMIGYEPYPGIRLGKELGELVRFYDLGGVFHSDELPNYGITKEEVESVRARLDLGGNDAFVIVGGPEEKVSFATDAIVRRLAAALDGVPAETRAATLDGRTVFSRPRPGAARMYPETDIPTIPVTGKMLDALSGKVPRPWDEVVDAIAKKYSMNKKLASQIFDSDYLSVFEQVVASTKVQPTFVASKLTEDITSLQRQGLDPAALTDQIIAEVFAKLDAGQIAKESVILIFEKLMKKEAGTVDDAVKALGVSSISDDELAFALDKVIGDNMAQVREKGMGALSMLMGRSMAILRGKADGQKINAMLKEKLEKMVGSGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MZV7</accession>
    <name>A0A075MZV7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase</fullName>
            <ecNumber evidence="8">2.7.8.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NTE_02732</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.8.15" evidence="8"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226986998.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MZV7"/>
    <dbReference type="STRING" id="1459636.NTE_02732"/>
    <dbReference type="GeneID" id="41598422"/>
    <dbReference type="KEGG" id="nev:NTE_02732"/>
    <dbReference type="eggNOG" id="arCOG03199">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023982_4_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003975">
        <property type="term" value="F:UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044038">
        <property type="term" value="P:cell wall macromolecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22926">
        <property type="entry name" value="PHOSPHO-N-ACETYLMURAMOYL-PENTAPEPTIDE-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22926:SF3">
        <property type="entry name" value="UNDECAPRENYL-PHOSPHATE ALPHA-N-ACETYLGLUCOSAMINYL 1-PHOSPHATE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="312"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF84774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="339" mass="35738" checksum="31E11F96A18583DA" modified="2014-10-29" version="1">MIAAVGYEALAYAAIVSAISFLAVYFLTPLAIRSLVAKGSVVQDYHKPGKPSVPRPAGPVLMIGIAAAELVLFAVTTNYAVLAILAATVIAFVVGYVDDKKVMPGWFKPVALIAAAVPIIVLGAHANSLNLVFGSAFIPLLYIPLILVIIPIAGNTVNSIDVLNGVASGFVAIATVPLLAAIAIFGSLDVFLAGLPLFFASIAFFKFHKYPSKIFPGDSGTLLLGAMYGALAIAGRAEIIGVVALLPAVVNSFLFLSSVKRIVEHRQVKARPVALLDDYKLAPSLDKAAPATLVRLILADGPLSEKEVAQKIFWLSMFSALLAFATIAIQYYFLMVVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N0L8</accession>
    <name>A0A075N0L8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helicase, type I site-specific restriction-modification system restriction subunit</fullName>
            <ecNumber evidence="3">3.1.21.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_02989</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.21.3" evidence="3"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N0L8"/>
    <dbReference type="STRING" id="1459636.NTE_02989"/>
    <dbReference type="REBASE" id="90010">
        <property type="entry name" value="NevSR1ORF2988P"/>
    </dbReference>
    <dbReference type="KEGG" id="nev:NTE_02989"/>
    <dbReference type="eggNOG" id="arCOG00880">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009326_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009035">
        <property type="term" value="F:type I site-specific deoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18032">
        <property type="entry name" value="DEXHc_RE_I_III_res"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18799">
        <property type="entry name" value="SF2_C_EcoAI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013670">
        <property type="entry name" value="EcoEI_R_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050742">
        <property type="entry name" value="Helicase_Restrict-Modif_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007409">
        <property type="entry name" value="Restrct_endonuc_type1_HsdR_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47396:SF1">
        <property type="entry name" value="ATP-DEPENDENT HELICASE IRC3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47396">
        <property type="entry name" value="TYPE I RESTRICTION ENZYME ECOKI R PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08463">
        <property type="entry name" value="EcoEI_R_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04313">
        <property type="entry name" value="HSDR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="179"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="416"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF85024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="932" mass="108807" checksum="AA3A23F3D8A18EC0" modified="2014-10-29" version="1">MVTTDSEFLTRREKIDVLLKEAGWDVKNVSQAILEVDTLQSDFKSQLYRTVSDTLKNEKDSKYADYLLLDGSGDPLAVIEAKKTSKDPILGEKQAELYAQDIKNQTGKDIFIYFTNGYEIWFWNKPHDNPRMVKGFHGRDALERLRFQNISKKDFEEIPINREITDRPYQIESIKRVLEGIGRGRRKFLIVQATGTGKTRVAMSLIDILLRSNRAQKILFLADRKALRDQAYEEGFKIFFPSESKTKVFSGDVDLKNHRLYASTIQTFMECYRDFSIGDFDVIISDEAHRSIYNKWKDVFTYFDCIQIGLTATPAQLIDRDTFRFFDCLDGKPTALYTYEQAVHDGYLVDFKVHEAQTHFQIEGIKSKDIPEEVKKKLLAEGKDEEDLDFEGTEIEKRVIVTGTNEAIICEYYEYSLKDKSGTLPAKTIIFAISKKHAKRLWESIERLYPEHRGRLANVIVSEDSRAQETLRQFKRENYPRIAISVDMLDTGVDIPEVCNLVFAKPVFSNIKFWQMIGRGTRSNEACKNHDWLPDGKKTEFLIFDFWKNFEFFDMHPEGKISTSSEALPTKIFLVRLQQYQYFKRNGDLQNAEAVLAKLIKSVDELPKDSANIRERLRDVEIVTQGKLFDNIAIEDEVVFLKEKIAPLMRYASDININRETFRLKTEQLGLAILTKNNEEFERAKETIGDYLMRLPRTIKEVERKEIIIDQILSKNYWKFIEYKDAMAMQEQLVEIMDNVRPEPVPKIVLDIDDLIQERKKILYGFPAKEEYIDVYKEKVEAHIKRLAFDNEVVKKLQTNQQLTEEDLHDLEDKLNSPDLFITEELLRKVYSQKRATIVDFVKHILGLYRFASPQDKISEAFKTYMIERNYLNANQVNFLRTLQTVFTKKKHIELDDLFESPFTNFGADAPIPLFSQEELHELVQLCNKLEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N0N8</accession>
    <name>A0A075N0N8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03004</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701509.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N0N8"/>
    <dbReference type="GeneID" id="41598674"/>
    <dbReference type="KEGG" id="nev:NTE_03004"/>
    <dbReference type="eggNOG" id="arCOG08805">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100103_1_0_2"/>
    <dbReference type="OrthoDB" id="9412at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="175" mass="19763" checksum="6A5CBF95E0B1A0BC" modified="2014-10-29" version="1">MSPKLKNESVTFRISGDILLAMRQLSQEGGVSLNTLVNNVLKSYVDWESTAVKAGFGVFQREVVKEAINSLDEDTLKKIAANTADTYKDMLLLMKGSSDLDSFIYMVKERAKRAGFNLREFEEEEGKKIVLQHDMGANWSTYCKIYHEKVINSIGHPVKIETTDNSLIIWVPKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N0T8</accession>
    <name>A0A075N0T8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HhH-GPD superfamily base excision DNA repair protein</fullName>
            <ecNumber evidence="5">3.2.2.21</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_03049</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alkylbase DNA glycosidase AlkA family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.21" evidence="5"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701548.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N0T8"/>
    <dbReference type="STRING" id="1459636.NTE_03049"/>
    <dbReference type="GeneID" id="41598717"/>
    <dbReference type="KEGG" id="nev:NTE_03049"/>
    <dbReference type="eggNOG" id="arCOG00464">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_72_5_2"/>
    <dbReference type="OrthoDB" id="8200at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032993">
        <property type="term" value="C:protein-DNA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032131">
        <property type="term" value="F:alkylated DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008725">
        <property type="term" value="F:DNA-3-methyladenine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043916">
        <property type="term" value="F:DNA-7-methylguanine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.30:FF:000004">
        <property type="entry name" value="DNA-3-methyladenine glycosylase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051912">
        <property type="entry name" value="Alkylbase_DNA_Glycosylase/TA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43003">
        <property type="entry name" value="DNA-3-METHYLADENINE GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43003:SF5">
        <property type="entry name" value="DNA-3-METHYLADENINE GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="4">
        <location>
            <begin position="42"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF85084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="202" mass="22277" checksum="630BE69A954149E8" modified="2014-10-29" version="1">MDAILHHLSGVDERLGSIITSVGSYTIATGGDPFQSLVRSIMYQQLAGSAADAIHARFLGLYRGRFPSPVRLAATPEAQLRAIGLSGRKTEYVKGLAADVSGGRLDLASLAAMEDELVIEQLTTVRGIGRWTAEMFLIFCLGRPDVLPVGDLGPQKAVQKAYFLRKLPSPERMEKIARPWRPYRSVATWYLWKSLEKFKTIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N0W1</accession>
    <name>A0A075N0W1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PepSY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701571.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N0W1"/>
    <dbReference type="GeneID" id="41598747"/>
    <dbReference type="KEGG" id="nev:NTE_03085"/>
    <dbReference type="HOGENOM" id="CLU_873205_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="318" mass="34157" checksum="D0C69A346B1DBD18" modified="2014-10-29" version="1">MSNLTGNKNKFLIPVFLVAILTVASFTIVMPRVLAQDTTGQENNDDNDATAPSENNTMTAPSENDNGDNTSTAPLEDNSTTTNENTGNNAMIAPSENDTMATPEESNNTTTTPEEDNGLNGSSENNNTATTPEGNAMNAPEENNTLTTPSENNTMTAPPEGSNDNNTLTAPSENNNTNTNNIINNNTNVNNAQVTQQIVGTVKVNNNQKASDFSEANLKIKRSGAEEAAKAHFDKGEVIDSHLSVVNNFLVFTVVVANVQFNTVNIVFVDAGNGDVIFISPPIPADHDDISNGRNNDCDCNCDDDGQKEHRQRHHHWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N184</accession>
    <name>A0A075N184_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03184</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701650.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N184"/>
    <dbReference type="STRING" id="1459636.NTE_03184"/>
    <dbReference type="GeneID" id="41598840"/>
    <dbReference type="KEGG" id="nev:NTE_03184"/>
    <dbReference type="eggNOG" id="arCOG13317">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2067697_0_0_2"/>
    <dbReference type="OrthoDB" id="384240at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="118" mass="13031" checksum="CBEBA7BE03E78320" modified="2014-10-29" version="1">MKKSIEGDYQVRIKLAEKVTANRDTDITFELADAKGTPVHDLEPIMGAGGHCVIISGDAKEFLHVHPVEQVGSTWRGGPQVTFMANFPRPGLYKIWGQFQRKGGTITESFTVRVTDNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N1H4</accession>
    <name>A0A075N1H4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N1H4"/>
    <dbReference type="KEGG" id="nev:NTE_03290"/>
    <dbReference type="HOGENOM" id="CLU_1943762_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="129" mass="14109" checksum="C33AE9C5D2F196D7" modified="2014-10-29" version="1">MIGAGASILCALALHADTMAAKSSMLEHCVTLNSKIDYSDLYRRIPVGLFNRWKPKGKMYSLKCTQCGAGFLSSYNLDAPICGKCLQKAKSLDSTVDHEKVCVKCGNSGVIYGKELCHACYFGFNKQQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N1Z1</accession>
    <name>A0A075N1Z1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase</fullName>
            <ecNumber evidence="4">3.2.2.21</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_03441</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.2.21" evidence="4"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701873.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N1Z1"/>
    <dbReference type="STRING" id="1459636.NTE_03441"/>
    <dbReference type="GeneID" id="41599079"/>
    <dbReference type="KEGG" id="nev:NTE_03441"/>
    <dbReference type="eggNOG" id="arCOG00464">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_72_3_2"/>
    <dbReference type="OrthoDB" id="8200at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032993">
        <property type="term" value="C:protein-DNA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032131">
        <property type="term" value="F:alkylated DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008725">
        <property type="term" value="F:DNA-3-methyladenine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043916">
        <property type="term" value="F:DNA-7-methylguanine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.20">
        <property type="entry name" value="DNA-3-methyladenine glycosylase AlkA, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037046">
        <property type="entry name" value="AlkA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051912">
        <property type="entry name" value="Alkylbase_DNA_Glycosylase/TA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43003">
        <property type="entry name" value="DNA-3-METHYLADENINE GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43003:SF5">
        <property type="entry name" value="DNA-3-METHYLADENINE GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="2" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="3">
        <location>
            <begin position="140"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF85469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="312" mass="35542" checksum="8ED1ACE934719DDC" modified="2014-10-29" version="1">MVDSIALSAVATFQLDFTVWALRRRDTNIIDRWDGTKYVRVLTFNNEPVKIAVRQEGTINDPKIAITLQSKKRAMTPVRARKDAQVLVQKMLGLDRDLTPLYTRARNNKDAVLISLGQQFLGVKPPCFSSIFETLINAIACQQVTLDLAILMLNRLSVKFGLEFEDDVDGTLLHAFPRPEDLADVSEQEMRKLGFSRQKARAIKELAMAVVDNETKLSNLSEMTNEQIVEYLSSIRGIGRWSAEYALLRGFGRIDTFPGDDIGAQNNLERLFHLDKKPDYAEVKKLTSRWHPYEGLVYFHLLLNKLQMRGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N207</accession>
    <name>A0A075N207_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701884.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N207"/>
    <dbReference type="STRING" id="1459636.NTE_03456"/>
    <dbReference type="GeneID" id="41599091"/>
    <dbReference type="KEGG" id="nev:NTE_03456"/>
    <dbReference type="eggNOG" id="arCOG08677">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_166567_0_0_2"/>
    <dbReference type="OrthoDB" id="12305at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="111" mass="12287" checksum="3E84A41A24DC1D8E" modified="2014-10-29" version="1">MSDRKEKSSEANSNQRGTKKFSSENTLDEGVIAFGEWLMSAEDLSARCGPLSLRKMINDDEILLFDAMLNQDVIVKMIGGVPECGACHNDTECMHIGFSICVAQMNRRNAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLE1</accession>
    <name>A0A075MLE1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2H2-type zinc finger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_00154</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699271.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLE1"/>
    <dbReference type="STRING" id="1459636.NTE_00154"/>
    <dbReference type="GeneID" id="41596092"/>
    <dbReference type="KEGG" id="nev:NTE_00154"/>
    <dbReference type="HOGENOM" id="CLU_2857227_0_0_2"/>
    <dbReference type="OrthoDB" id="378006at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="31"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF82236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="65" mass="7357" checksum="6C2BE85BE9DC6F91" modified="2014-10-29" version="1">MNGNMEKEGKQVPLAKKEEVKAQVPAERPRFECEECNKTFPSSLDLEEHRKQDHVAKNTSSTTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLI4</accession>
    <name>A0A075MLI4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mn-containing catalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00239</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the manganese catalase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699328.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLI4"/>
    <dbReference type="STRING" id="1459636.NTE_00239"/>
    <dbReference type="GeneID" id="41596154"/>
    <dbReference type="KEGG" id="nev:NTE_00239"/>
    <dbReference type="eggNOG" id="arCOG07055">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057467_1_0_2"/>
    <dbReference type="OrthoDB" id="195771at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd01051">
        <property type="entry name" value="Mn_catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007760">
        <property type="entry name" value="Mn_catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039377">
        <property type="entry name" value="Mn_catalase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05067">
        <property type="entry name" value="Mn_catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="302" mass="33488" checksum="2765273ABAF1846E" modified="2014-10-29" version="1">MWLSVEKLVNEIKQDKPDPAAAKALQEGLGGQFGEMRTLMQYQFQNFNFRGDAKPFRDVVRAVGTEEIGHVELISTTINMLLDGSSTSSSTKAVDPDSLPLADALDGNGNIHHFLVAAQSSRPVDAAGNPWSALYVYDSGNLVLNLFYNLMLEATGRLQKCRLYEMSKNKTFRSTVSYLIVRDLAHEKVFAKALEVLGVNWGKVLPVPKVDTDKMPEVKALEKKNLHNQQWTFSKESQLGQIFKGESPFGDGEIETMDGLPDGFDVPVLPDREEEFAPGLDKDLKSKAQEIAGITRQQRAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MM54</accession>
    <name>A0A075MM54_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">eCIS core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_00485</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MM54"/>
    <dbReference type="STRING" id="1459636.NTE_00485"/>
    <dbReference type="KEGG" id="nev:NTE_00485"/>
    <dbReference type="eggNOG" id="arCOG10869">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_414830_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025295">
        <property type="entry name" value="eCIS_core_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13699">
        <property type="entry name" value="eCIS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eCIS core" evidence="2">
        <location>
            <begin position="108"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="480"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="488"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF82566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="661" mass="72921" checksum="3AD32A703B6BEAB2" modified="2014-10-29" version="1">MSTINRSRPMSFASSYRRKDSTTDSKSLGVVKAPSYRNDSGEYSGNSIIHLRQAIGNQAIRRLMYSDAGFDFANITIQPKLKVNHPHDAHEQEAESKIDGARSGGGSPLDTGTREFMESRFGHDFSNVRLHTDEKAARSARSLNALAYTIGNDITFGKGQYQPGTRQGRELLAHELAHTIQQRGADAPPSNDPQGIHETSARTAAQNVVNGQSVRTELPASGVGLSMQPAEDEERKKAIAEAEAGAARIDQLLKEDEEESLPEMPRRPTTLSLIKPDPRFQARMVTDEQIYAPLKEFDEREKAAKTKKRIVEEALDETRPERFQMFRKVLNEHGFAGDVLASFMSERIPMRDLQVLRRYGLEWPHWYNRSKFQGKVEDALDRFFADQHYIQYGRSPVVNEFTKEDQEALEREQMRQRVIQAWLTTISHATGSLGGALGAGITDLFTDDPEKIAAGGGLGTAATGVLGAFAQARINQGTYVPDVENPLRPEPTPQPKPARPKGYGNPEASAKAAIKSETKKAPEPSLTELQQEIVQDLMSQGHKLAPRTATEAAKGAAEAIPTSEVRSSDVRLVNGKLREVTAFEGKLDNLGGRLARKGGQKPDEIFVQVNTPGVKKEDIIRLIQGPNGIRYGYQELAGVYVKVFDSEGAVLWSGTFGSFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMA2</accession>
    <name>A0A075MMA2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00163</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMA2"/>
    <dbReference type="STRING" id="1459636.NTE_00163"/>
    <dbReference type="KEGG" id="nev:NTE_00163"/>
    <dbReference type="HOGENOM" id="CLU_200166_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="69" mass="8133" checksum="87D9BEA021C05BF1" modified="2014-10-29" version="1">MLYQSTEFIARMQIKPIEIKKLQWRAGRGLPYCHTCGEYATSEAYFDVQNYVVVQRYCEKCLLAGEYDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMN3</accession>
    <name>A0A075MMN3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, ribosomal protein N-acetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00441</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699477.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMN3"/>
    <dbReference type="STRING" id="1459636.NTE_00441"/>
    <dbReference type="GeneID" id="41596317"/>
    <dbReference type="KEGG" id="nev:NTE_00441"/>
    <dbReference type="eggNOG" id="arCOG00845">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_951933_0_0_2"/>
    <dbReference type="OrthoDB" id="43754at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43072:SF52">
        <property type="entry name" value="GCN5-RELATED N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43072">
        <property type="entry name" value="N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="291" mass="33970" checksum="CD33AE228B8EA978" modified="2014-10-29" version="1">MTIKIRRAKSSDKEEILSFCTNTFSWGDYIDQVWDYWFSGKNGRLFVVEDDKGRRRIGMSHVAMCPRGRSAWLEGVRVRPEYRRFNIATELLNEMLAYAGRHGARQASAIVSSENVPSQRMMEKNGFAVVSRWVYYSTDQKFGRQKTKARLATSADIDRIWTYLQKSRIYRLSAGTYVRAWHWYPLDKKALRGLIRKKSVVMTGEIDGVVIINAKGYWKRTDVLQIVYLDSASKKSLQDLLAFAANMYSKGRYERMHVVCYDSKSITSMLKSFKKEEDSELFLLYNKKFKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMS2</accession>
    <name>A0A075MMS2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Permease, glycerol uptake facilitator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NTE_00058</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987080.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMS2"/>
    <dbReference type="STRING" id="1459636.NTE_00058"/>
    <dbReference type="GeneID" id="41596009"/>
    <dbReference type="KEGG" id="nev:NTE_00058"/>
    <dbReference type="eggNOG" id="arCOG04431">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020019_3_1_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45724:SF13">
        <property type="entry name" value="AQUAPORIN NIP1-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45724">
        <property type="entry name" value="AQUAPORIN NIP2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
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    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
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        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF82142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="231" mass="24108" checksum="CED42B68C2A24F5E" modified="2014-10-29" version="1">MSETSKTAVRLAADKKRFLAELVGTFVIVVFATGSVVIDARLGGVLGTPFAAICPAIAVALMVYAFGKISMAHFNPAVTLGFLITGHITPRQFPVYFAAEIIGALLASAFVAFAIGTEANLGANAPNYSFPLPLIIAAEVLATGLLMAVIYVAVYTRGLRGFGGIAIGGMIGLDILFLSFVSGASMNPARSLAPALLSGFITDLWLYWTATFAGAAVVATVVARKKKLLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMV8</accession>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMV8"/>
    <dbReference type="KEGG" id="nev:NTE_00696"/>
    <dbReference type="HOGENOM" id="CLU_3075138_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="52" mass="6264" checksum="E3FF4806BB3A29A9" modified="2014-10-29" version="1">MSMIFYPELAVGEHLTIWHGGVEHTHTERFFLFTFVCRPARLILSFEMLEWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMX4</accession>
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        <name evidence="2" type="ORF">NTE_00100</name>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMX4"/>
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    <dbReference type="KEGG" id="nev:NTE_00100"/>
    <dbReference type="eggNOG" id="arCOG00062">
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    </dbReference>
    <dbReference type="GO" id="GO:0016787">
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07581">
        <property type="entry name" value="nitrilase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
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    </dbReference>
    <dbReference type="InterPro" id="IPR001110">
        <property type="entry name" value="UPF0012_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088:SF27">
        <property type="entry name" value="DEAMINATED GLUTATHIONE AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088">
        <property type="entry name" value="NITRILASE-RELATED"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00795">
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
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    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
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    </dbReference>
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        <property type="entry name" value="UPF0012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="263" mass="28700" checksum="FD32AEFBEFFAC57B" modified="2014-10-29" version="1">MKSSEDKQDNLRQSVAYIEQAAAGKAQLVCFPEFQMAFSPGTQTAFELSKLAETVQGSFVTTLRKAAKAGKVEVVAAMYEKGAGNRVYDTAVVISSKGAITSVYRKLHLYDALGFKESKKLIPGKKLVKPAKTAAAGNIGVMICYDIRFPELSRLLTIKGASVLVAPSGWVQGPMKEEHWQTMLKARAIENGSYVVAPDQVGNIYAGRSMVIDPFGAVLLDMGQREGMETVELDMDKVKQVRQSLPLLKNRRTDVYSLSSKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMZ7</accession>
    <name>A0A075MMZ7_9ARCH</name>
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        <submittedName>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMZ7"/>
    <dbReference type="KEGG" id="nev:NTE_00768"/>
    <dbReference type="HOGENOM" id="CLU_3039192_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="54" mass="6471" checksum="3779550C504BBA80" modified="2014-10-29" version="1">MKSRMEDLVWECRQEDDMDKKVKLFNRIRKLLPNPPKMPSMVTDDYINSALDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MN32</accession>
    <name>A0A075MN32_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699792.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MN32"/>
    <dbReference type="STRING" id="1459636.NTE_00845"/>
    <dbReference type="GeneID" id="41596688"/>
    <dbReference type="KEGG" id="nev:NTE_00845"/>
    <dbReference type="eggNOG" id="arCOG10526">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1003322_0_0_2"/>
    <dbReference type="OrthoDB" id="10916at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="286" mass="30688" checksum="FCD3D86009212E31" modified="2014-10-29" version="1">MQQKKTPGGRSTTATTLAAVLPAVVVAGLLVLTASGDLKAPIEDLTVAAASLSAAAISIPVMLGQKTRHGYKPFLALSVGLALWAVAEILWAYFELVAGIEVPYPSVPDIFYLSGYAFVALFLFSLYRVSPRAFENKMVVIVIAITVESFFLNFFLIQLVENIVGFAQPTADDWLLLAVSVAYPLLDGILLVPAAVLITGYQLGIMSRFSILLFAAAVVLFAVGDTGFSYFALTDFAALQDEKVWNTFYAVSYVLFAGSLLSVLLEMRASPKQVGGIKAGATKDYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MN54</accession>
    <name>A0A075MN54_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">NTE_00885</name>
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    <organism evidence="1 2">
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
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            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MN54"/>
    <dbReference type="STRING" id="1459636.NTE_00885"/>
    <dbReference type="KEGG" id="nev:NTE_00885"/>
    <dbReference type="HOGENOM" id="CLU_1615363_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="165" mass="18719" checksum="7CFB949EA3676E3C" modified="2014-10-29" version="1">MGPILQCSVMHDVYNFQSRSEGTPVSKKTQKKQVDTQELKRLLRDPIIVRIVTVLDIASLSVLELFEYGLTRKDVNHAMVNGVIELNKAKESSPELGEYSTEALFAIAGDVYFQEFLFSKARLTELGLYLLDCLKGCQTEQDIIEKVMQRFDTGTFIPPEHPHKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNA7</accession>
    <name>A0A075MNA7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00559</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNA7"/>
    <dbReference type="STRING" id="1459636.NTE_00559"/>
    <dbReference type="KEGG" id="nev:NTE_00559"/>
    <dbReference type="HOGENOM" id="CLU_3093924_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="51" mass="5795" checksum="66C8B3C2F2C3146C" modified="2014-10-29" version="1">MSLTCPKCCTVLNMKYFDGGYWVASKDPVWTCSSCNTFYRAKELKKSLCSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNG5</accession>
    <name>A0A075MNG5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PRC-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00673</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699661.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNG5"/>
    <dbReference type="STRING" id="1459636.NTE_00673"/>
    <dbReference type="GeneID" id="41596532"/>
    <dbReference type="KEGG" id="nev:NTE_00673"/>
    <dbReference type="HOGENOM" id="CLU_1302578_0_0_2"/>
    <dbReference type="OrthoDB" id="9507at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018684">
        <property type="entry name" value="DUF2171"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09939">
        <property type="entry name" value="DUF2171"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="195" mass="21862" checksum="2E978B42C7F39D58" modified="2014-10-29" version="1">MTDDVTSYVDWSELKGKEARGTQGDVDLGEVRELGRNYIVTQKGRVSREKFYIPKYLAVGYDGHTVYFNVTEAQTQRFSREAPPSYEEYAQYRVAHVPPDIETRVHVIKSRRTVDPTRESPVLDWDSIVHKNVRAADGEPVGSVVAVLGDAIHVETQGSRSQFLIPKERVQGFDGAEVRLDAPVSDLGQYARPGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNH4</accession>
    <name>A0A075MNH4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_00275</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNH4"/>
    <dbReference type="STRING" id="1459636.NTE_00275"/>
    <dbReference type="KEGG" id="nev:NTE_00275"/>
    <dbReference type="eggNOG" id="arCOG01962">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2461614_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF82357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="88" mass="9679" checksum="BEC4B80D118AC90C" modified="2014-10-29" version="1">MMPRGLAAAVLATLPLTLGLPNAGAYPQIVFVIILSSVVITTGGLVKYRKRQEQSTQALRRQKKEKKEEDQKKSLLQSSAAAREMIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNJ7</accession>
    <name>A0A075MNJ7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutamate--cysteine ligase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01058</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385110.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNJ7"/>
    <dbReference type="STRING" id="1459636.NTE_01058"/>
    <dbReference type="GeneID" id="41596879"/>
    <dbReference type="KEGG" id="nev:NTE_01058"/>
    <dbReference type="eggNOG" id="arCOG04732">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_665016_0_0_2"/>
    <dbReference type="OrthoDB" id="7289at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004357">
        <property type="term" value="F:glutamate-cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042398">
        <property type="term" value="P:modified amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050141">
        <property type="entry name" value="GCL_type2/YbdK_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006336">
        <property type="entry name" value="GCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36510">
        <property type="entry name" value="GLUTAMATE--CYSTEINE LIGASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36510:SF1">
        <property type="entry name" value="GLUTAMATE--CYSTEINE LIGASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04107">
        <property type="entry name" value="GCS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="415" mass="47667" checksum="B644BAC33A4A4836" modified="2014-10-29" version="1">MAHPKKIYAQADELKARVKRHARRRDETFRVGVEIEMCLLDGKDGRPANAAPVIECLSRRHHQIDYEYGKCQLEFKTDPVSMDKIEGLNLQFEEFIEHLEKAVRKAGKDVVPVFLGANPSPFALADGLITDRPRYARLAHWQKKLPDIEMDGQKFKAVHVAPAIQGFHLHLQGKNPHFTAMMFNHILNLVPSVILLGANSRLFAGRVFSLHEPRLFMYDQSEQQNSGFPGIPRYLAGVEDYIDYIISRKPVIAKDYLEMEKERHDDCRIRLNASSYRVEARVMSVQPTPRTMMAMIEFFIGYLQKSIHEERELRPLAALREERQSVVRSGFNAKTHFDVVQTAKHQVELARKGLADLGIKPAFLNILENRIENRTTAGEYVAHLWQSKFNGSVEKTLAEVIADVWEKTRNNRAIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNL0</accession>
    <name>A0A075MNL0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Copper-containing nitrite reductase</fullName>
            <ecNumber evidence="3">1.7.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">NTE_00315</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>nitric oxide + Fe(III)-[cytochrome c] + H2O = Fe(II)-[cytochrome c] + nitrite + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15233"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.7.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Cu(+)</name>
            <dbReference type="ChEBI" id="CHEBI:49552"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotrimer.</text>
    </comment>
    <dbReference type="EC" id="1.7.2.1" evidence="3"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699387.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNL0"/>
    <dbReference type="STRING" id="1459636.NTE_00315"/>
    <dbReference type="GeneID" id="41596219"/>
    <dbReference type="KEGG" id="nev:NTE_00315"/>
    <dbReference type="eggNOG" id="arCOG02926">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG03914">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032707_0_0_2"/>
    <dbReference type="OrthoDB" id="12293at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050421">
        <property type="term" value="F:nitrite reductase (NO-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd11024">
        <property type="entry name" value="CuRO_1_2DMCO_NIR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000923">
        <property type="entry name" value="BlueCu_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052721">
        <property type="entry name" value="ET_Amicyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001287">
        <property type="entry name" value="NO2-reductase_Cu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36507">
        <property type="entry name" value="BLL1555 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36507:SF1">
        <property type="entry name" value="BLL1555 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00127">
        <property type="entry name" value="Copper-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00695">
        <property type="entry name" value="CUNO2RDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 10" id="KW-0186">Copper</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="15">
        <location>
            <begin position="138"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="14">
        <location>
            <begin position="276"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="Blue (type 1) copper" evidence="13">
        <location>
            <begin position="507"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="66"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="84"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="binding site" description="type 1 copper site" evidence="10">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="type 1 copper site" evidence="10">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="type 1 copper site" evidence="10">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="type 1 copper site" evidence="10">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="type 1 copper site" evidence="10">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="type 1 copper site" evidence="10">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="type 1 copper site" evidence="10">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601287-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AIF82397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="591" mass="63120" checksum="30409EE6D5B6374C" modified="2014-10-29" version="1">MSSLTVSVDNNDNNNSYNHSSSSNSGSSQNRSAGGGEGGWGKLTVAILAGMLLVSTLIVGITLPLSSSLSPSSSPSEERETMVAAERSSVAATAAANAERDAEKSADDDDFELYGHTSSAADEAAVKELTLVAQEAELEIAPGKVVKTWTFNGTVPGPALMFAEGDHVRIKFINKTPIPHTLHLHGNHDDANDGVLPQIMPNDSYIYNITAGPAGALMYHCHAHPTSLHIRMGMYGAMIIDPKDKPLQPAREFVMVMGEYDSKDVMKFEAEYYPINGYADQYMKYPLEARNGELVRMYVINIGTTIPYQFHLHSTIFKAYPSGLLSNEPIDAQTIAVGPGDATIVEARWKYPGDYLFHSHGIQEERGNMGQIHVVDSNQANNSNNGSTLANNNSSTALTNATTTTISAGKSVSMFDWQYELQNKLQKPKVFNYTDDELMGKSVAQNNNHGAVTHDEAAGAASHNNTHSDEGTAVATTETRTTAATTNNSTAKQTTAVSIASGASNPNSGLSYEPLEVTVKSGSTIIWANKDSIMHTATSGSPEAGPSGVFDTGIIGGSGEVSETAINAKPGIYDYYCTLHPHMKGRLTVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNR7</accession>
    <name>A0A075MNR7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385043.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNR7"/>
    <dbReference type="STRING" id="1459636.NTE_00695"/>
    <dbReference type="GeneID" id="43502576"/>
    <dbReference type="KEGG" id="nev:NTE_00695"/>
    <dbReference type="eggNOG" id="arCOG07781">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_898946_0_0_2"/>
    <dbReference type="OrthoDB" id="11838at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17963">
        <property type="entry name" value="Big_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="196"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="309" mass="32258" checksum="91CD400BEFCFB1B1" modified="2014-10-29" version="1">MTTYRKSEDKSRIAIFALVAVLAFGFVISQPALAANNGNGNNGNGNNGNGNNGNGNNGNGNNGNGNNGNLSADSQSVVIDENTSVEITLTGSGPSGFTYEIGTNPTHGTLTGTAPNMMYTPDTDYFGTDSFTFHTHKGGNDSPDATVSITVNEVVVVVTPPSDDEDDDDNNNSIGDNGSGSGDDDQGTGDNGSDGGNDNDNQGVQDDNDNDNTNNSGGNDDNQQESHVGNSHSWSVAIQFADKTADMDFTQVPESTTGVTLYNAVRGPLGVNFVDLLMSFDLKGIHSGDLTDGQMVWLLEHFDELLRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNX0</accession>
    <name>A0A075MNX0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zn-dependent alcohol dehydrogenase</fullName>
            <ecNumber evidence="9">1.1.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NTE_00762</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.1" evidence="9"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699733.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNX0"/>
    <dbReference type="STRING" id="1459636.NTE_00762"/>
    <dbReference type="GeneID" id="41596613"/>
    <dbReference type="KEGG" id="nev:NTE_00762"/>
    <dbReference type="eggNOG" id="arCOG01455">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_2_2"/>
    <dbReference type="OrthoDB" id="73567at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030554">
        <property type="term" value="F:adenyl nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043168">
        <property type="term" value="F:anion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051262">
        <property type="term" value="P:protein tetramerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08240">
        <property type="entry name" value="6_hydroxyhexanoate_dh_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000039">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050129">
        <property type="entry name" value="Zn_alcohol_dh"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43401:SF4">
        <property type="entry name" value="D-ARABINOSE 1-DEHYDROGENASE (NADP(+))"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43401">
        <property type="entry name" value="L-THREONINE 3-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="8">
        <location>
            <begin position="8"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF82840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="350" mass="36764" checksum="26CE2F486260CEC9" modified="2014-10-29" version="1">MKAARIIKTKEPLKVEDIATPKPSGEQVLVKVDSAGVCHSDLHLWEGGYAGPQGVFMKVEDRGVKFPLTPGHEVAGSIVEMGDKVTGYAKGEKVLVYPWIGDGVCPACKAGEENLCDAPRSLGVYQDGGYGEYALVPSYKYLVKLGNYDTAAAASLACSGLTAFTAVKKAAVKDGETLVIVGAGGLGLMAVQIAKAITGAKIAVVDIDDKKLDEAKKLGADIAVNSGKGDPVQGVKDATKGLGAEAVIDFVNNAKTAPNSFNMLRKRGKLVMVGLFGGSMELNLPLIPLRAFTLTGAYTGKYADLVELVEIAKKGKIQSVVSRRFKLDEVNTALEELKAGKILGRAVINP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPB4</accession>
    <name>A0A075MPB4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01323</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700171.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPB4"/>
    <dbReference type="GeneID" id="41597124"/>
    <dbReference type="KEGG" id="nev:NTE_01323"/>
    <dbReference type="HOGENOM" id="CLU_126369_0_0_2"/>
    <dbReference type="OrthoDB" id="6536at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="183" mass="20629" checksum="34EE3E86B3C26B8D" modified="2014-10-29" version="1">MSEPIDPQEGINVNTQSELRLDEVDLKLIDLLLSGHTTRQSAQILERPLSTIQRRARLLIQNGALKPTFELGYSRLRVKKGFLHVYLDDGNVSDAVDKLLARDGIYSVGAHIGNSDIVGFFVFQDSREVLDLIAWTKQMNGVERVVWSEEVYAMSTSPKLTKILGKNKREKTSKRVTTTTTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPC3</accession>
    <name>A0A075MPC3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00919</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPC3"/>
    <dbReference type="KEGG" id="nev:NTE_00919"/>
    <dbReference type="HOGENOM" id="CLU_3194328_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="45" mass="4885" checksum="6538A55B8574AF5F" modified="2014-10-29" version="1">MVDFSTFAFPIMYVAIAGLGITLAYVVAGSKIRQLLHKTPVQSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPD1</accession>
    <name>A0A075MPD1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00999</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699911.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPD1"/>
    <dbReference type="GeneID" id="41596826"/>
    <dbReference type="KEGG" id="nev:NTE_00999"/>
    <dbReference type="HOGENOM" id="CLU_1673902_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="157" mass="16903" checksum="A2FCE365D2A8813A" modified="2014-10-29" version="1">MGTVMNTFRTKKWNLFLLAAAAIVLAAPLSYASAQEAAAEASSMPSFAANGNDNQSVKVTAQGNDIIVKFYGNDVYRGYGEFKASGEHLYACDKKGDGKTVTTWLFWNGEWRGSVSDHTGVKDGCGHKNLSIKEGTSVWLSVCLEGFGCSYPVWGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPH9</accession>
    <name>A0A075MPH9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF309 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01394</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385181.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPH9"/>
    <dbReference type="STRING" id="1459636.NTE_01394"/>
    <dbReference type="GeneID" id="41597190"/>
    <dbReference type="KEGG" id="nev:NTE_01394"/>
    <dbReference type="eggNOG" id="arCOG03705">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1465195_0_0_2"/>
    <dbReference type="OrthoDB" id="28179at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3450.10">
        <property type="entry name" value="TTHA0068-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005500">
        <property type="entry name" value="DUF309"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023203">
        <property type="entry name" value="TTHA0068_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34796">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34796:SF1">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03745">
        <property type="entry name" value="DUF309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140663">
        <property type="entry name" value="TTHA0068-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="188" mass="21526" checksum="03A511A0FA31416E" modified="2014-10-29" version="1">MQRYFVHLKNSAYTPKDAAVLLARARELADDEKAIVRDSRVSKKYIEFDTSIPDGVDISGLVGRLEKISPLASYEHIVERHVEKGEAIKRAIELFNDEKYWGTHEALEAVWKETPSGQERDLLNGVILVAAAFVHDEKDEREICMSILRRARKKLEGATGKYHGIDMDRFVERVQEILNTGIIERFTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPL1</accession>
    <name>A0A075MPL1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Permease, glycerol uptake facilitator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NTE_00672</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699660.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPL1"/>
    <dbReference type="STRING" id="1459636.NTE_00672"/>
    <dbReference type="GeneID" id="41596531"/>
    <dbReference type="KEGG" id="nev:NTE_00672"/>
    <dbReference type="eggNOG" id="arCOG04431">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020019_3_1_2"/>
    <dbReference type="OrthoDB" id="36050at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45724:SF13">
        <property type="entry name" value="AQUAPORIN NIP1-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45724">
        <property type="entry name" value="AQUAPORIN NIP2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF82752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="235" mass="24332" checksum="6D8F157AD4E7B93A" modified="2014-10-29" version="1">MKRKDPSDAEKVIPLSKRIVAEFIGTFTLVFAAAGASVADTLSGHELGALAVVAAPGLAIAAMIYAVDKISGAYFNPAISIGFALTGHLRKRDLPFYIAVQVAAAIVASLVVAFAIAPYGHSDATGLTVPHTGWLASFVIEIVFTFILMFVAISLKEDVGYKAFGGIAIGAAITALGIMGMPVSGASMNPARSFGPALVAGNFSDQWVYWVAPIIGAVVAVLAFEMAKDNKKKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPP8</accession>
    <name>A0A075MPP8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Esterase/lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_00744</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699717.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPP8"/>
    <dbReference type="STRING" id="1459636.NTE_00744"/>
    <dbReference type="ESTHER" id="9arch-a0a075mpp8">
        <property type="family name" value="Hormone-sensitive_lipase_like"/>
    </dbReference>
    <dbReference type="GeneID" id="41596596"/>
    <dbReference type="KEGG" id="nev:NTE_00744"/>
    <dbReference type="eggNOG" id="arCOG02638">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012494_6_0_2"/>
    <dbReference type="OrthoDB" id="33195at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="92"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF82822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="331" mass="35758" checksum="DB94E33D5791B667" modified="2014-10-29" version="1">MSSGNVTVSEITKVEQKTREFLEGLKKQGGPPIQTLSPKDARAVLSSLQSGPVTKLPAEIEDRTIPGGPGGKEVSIRIVRPQGSGNKTLQAVMYFHGGGWVLGGSDTHDRLVRELASKANVAIVFVNYTPSPEARYPVPLEEVYAATKWVAQNGKSVNVDASRLAVAGDSVGGNMAIAVTLLAKERGGPKMTFQALFYPVTDANLDSPSYTMYQDGFWLTREGMRWFWNNYAPDNNSRKEPTASPLQAPIDQLKGLPPALIITDEFDVLRDEGEAYAHKLMQAGVPVTATRYLGTIHDFVMLNAIADTPAARGAIDQASEMLKRAVLSSAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPS3</accession>
    <name>A0A075MPS3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPS3"/>
    <dbReference type="STRING" id="1459636.NTE_01130"/>
    <dbReference type="KEGG" id="nev:NTE_01130"/>
    <dbReference type="eggNOG" id="arCOG00833">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060131_7_2_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="117"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="205" mass="22718" checksum="66F2B750D4CC59D3" modified="2014-10-29" version="1">MITSTRAMTASLIKTTTTDNEAAAAIDVLVLAFSADPAARWAWPDPLQYLTHFPSFVKAFGGRAFTHGSAYYVDGYAGVALWLPPDVHPDEDELTTLLQRTVPEEIQKDALAVFEQMGSYHPSEPHWYLPLIGVDPSQQGKGFGSALMQHALVTCDRDHKLAYLESSNPKNIPLYERHGFELLGTIHAGKSPTIFPMLRKPRTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPV5</accession>
    <name>A0A075MPV5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00809</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPV5"/>
    <dbReference type="KEGG" id="nev:NTE_00809"/>
    <dbReference type="HOGENOM" id="CLU_2165139_0_0_2"/>
    <dbReference type="OrthoDB" id="6489at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="110" mass="12968" checksum="66BFECB12A1C3B7D" modified="2014-10-29" version="1">MLWKTRCGHFATRSYADAHGGLCRKCHANFAALVELEKRYGEDALVEYWYSAILINLPESKEEMKCFISHLIDFYQQKLIEMPSKQRYIRKMLYMLQSVLEPASDVETLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPX4</accession>
    <name>A0A075MPX4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01558</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPX4"/>
    <dbReference type="STRING" id="1459636.NTE_01558"/>
    <dbReference type="KEGG" id="nev:NTE_01558"/>
    <dbReference type="HOGENOM" id="CLU_2032936_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="103" mass="11734" checksum="942FE46FB9C460C4" modified="2014-10-29" version="1">MDDEKLGVKPEILFRIYGQIEAQAKDSAPVQVRNELRISQDARIKTRFYIAVSDRMAQYLITAVQKQTSGDAIGLKSYFYKLQEQLMGQMFAGAKDTINISLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQ29</accession>
    <name>A0A075MQ29_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Universal stress protein UspA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_00896</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699835.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQ29"/>
    <dbReference type="STRING" id="1459636.NTE_00896"/>
    <dbReference type="GeneID" id="41596736"/>
    <dbReference type="KEGG" id="nev:NTE_00896"/>
    <dbReference type="eggNOG" id="arCOG02053">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049301_11_0_2"/>
    <dbReference type="OrthoDB" id="105697at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00293">
        <property type="entry name" value="USP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46268">
        <property type="entry name" value="STRESS RESPONSE PROTEIN NHAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46268:SF6">
        <property type="entry name" value="UNIVERSAL STRESS PROTEIN UP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UspA" evidence="2">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF82972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="149" mass="16100" checksum="D979AEE321118A61" modified="2014-10-29" version="1">MYRKILVPYEGSQFSERAAEHAAYLAKLSGAKVTFLTVTALPSLIYTYNEAVNAAISEAAELLIMSSESPVVRSLKSRVEKCKKRGIDAKLVHTVGDPAMLVLETARKEGTDLIVLGSKGLKGVSKLKVFGSVARKVTELLVCPVLLVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQ38</accession>
    <name>A0A075MQ38_9ARCH</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00911</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQ38"/>
    <dbReference type="STRING" id="1459636.NTE_00911"/>
    <dbReference type="KEGG" id="nev:NTE_00911"/>
    <dbReference type="HOGENOM" id="CLU_2662138_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="75" mass="8546" checksum="79780D828D9E34DE" modified="2014-10-29" version="1">MGWRIALSILTFFGSVIGIILWLFFYAENFNVYQNIAVVVVILIGFMAIMGATWVSWGMKQQRAWGSKRGDPRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQH8</accession>
    <name>A0A075MQH8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PDK repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_01408</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQH8"/>
    <dbReference type="STRING" id="1459636.NTE_01408"/>
    <dbReference type="KEGG" id="nev:NTE_01408"/>
    <dbReference type="eggNOG" id="arCOG02508">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1736337_0_0_2"/>
    <dbReference type="OrthoDB" id="103676at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00146">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022409">
        <property type="entry name" value="PKD/Chitinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18911">
        <property type="entry name" value="PKD_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00089">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="PKD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="2">
        <location>
            <begin position="83"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF83473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="150" mass="16504" checksum="3BFEA8F219FE42D4" modified="2014-10-29" version="1">MDAYLYKFDLNCVHCLPRVSSKNNALVFGIIGAVAIALVVVYTVPLKLPGEKPKTFRVNADNFFKIKVGEKAPFVGVARDGVEPYRYAWNFGDGGTSQLQNTTHVYTKEGSYKVTLAVTDAAGTVTSISNTVTVYPPDANFTRQDRLLDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQJ1</accession>
    <name>A0A075MQJ1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NTE_01281</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700135.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQJ1"/>
    <dbReference type="STRING" id="1459636.NTE_01281"/>
    <dbReference type="GeneID" id="41597084"/>
    <dbReference type="KEGG" id="nev:NTE_01281"/>
    <dbReference type="eggNOG" id="arCOG01972">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090389_10_2_2"/>
    <dbReference type="OrthoDB" id="35385at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000001">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45663">
        <property type="entry name" value="GEO12009P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45663:SF11">
        <property type="entry name" value="GEO12009P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4 6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Thioredoxin" evidence="7">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <feature type="site" description="Deprotonates C-terminal active site Cys" evidence="5">
        <location>
            <position position="30"/>
        </location>
    </feature>
    <feature type="site" description="Contributes to redox potential value" evidence="5">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <feature type="site" description="Contributes to redox potential value" evidence="5">
        <location>
            <position position="38"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="6">
        <location>
            <begin position="36"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF83350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="114" mass="12590" checksum="E808DEDD1E0FFB71" modified="2014-10-29" version="1">METTNNSVLHVNTKTWDSEVIKSDLPVFVDFWAEWCGPCRMVGPAVEQIAKVMAGKVKVAKLNVDENQEIAMKYGVQSIPSLIIFKGGKEVGRTIGAMPKESYLKFIESTLAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQQ6</accession>
    <name>A0A075MQQ6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent dethiobiotin synthetase BioD</fullName>
            <ecNumber evidence="1">6.3.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">DTB synthetase</fullName>
            <shortName evidence="1">DTBS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Dethiobiotin synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">bioD</name>
        <name evidence="2" type="ORF">NTE_01810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(7R,8S)-7,8-diammoniononanoate + CO2 + ATP = (4R,5S)-dethiobiotin + ADP + phosphate + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15805"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:149469"/>
            <dbReference type="ChEBI" id="CHEBI:149473"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the dethiobiotin synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.3" evidence="1"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700566.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQQ6"/>
    <dbReference type="STRING" id="1459636.NTE_01810"/>
    <dbReference type="GeneID" id="41597575"/>
    <dbReference type="KEGG" id="nev:NTE_01810"/>
    <dbReference type="eggNOG" id="arCOG00100">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072551_3_1_2"/>
    <dbReference type="OrthoDB" id="50320at2157"/>
    <dbReference type="UniPathway" id="UPA00078">
        <property type="reaction ID" value="UER00161"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004141">
        <property type="term" value="F:dethiobiotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03109">
        <property type="entry name" value="DTBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00336">
        <property type="entry name" value="BioD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004472">
        <property type="entry name" value="DTB_synth_BioD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00347">
        <property type="entry name" value="bioD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43210">
        <property type="entry name" value="DETHIOBIOTIN SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43210:SF5">
        <property type="entry name" value="DETHIOBIOTIN SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13500">
        <property type="entry name" value="AAA_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006755">
        <property type="entry name" value="DTB_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="1">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="12"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="116"/>
            <end position="119"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="231" mass="25064" checksum="303E7D961951DEFC" modified="2014-10-29" version="1">MRGVFVTGTDTGIGKTVVAAGIAWLLKKKGIDVAAMKPFATGGKFFSKKFKSEDTAILAAATRAVESDEELNPVFFRVPASPLMAAQILKKSPPDVHGALFPLKKLGIKHQFVVVEGIGGLMVPLTEREFVADFVRLADLPVVVVTHPRLGTLNHTLLTVRVCRDFGLDIRGIIVNLMPKKPSAVERNAPHVMQRLAGVPVLAVLPEMKKPDYKEIGRLLEKTSIAEKILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQT9</accession>
    <name>A0A075MQT9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700228.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQT9"/>
    <dbReference type="STRING" id="1459636.NTE_01393"/>
    <dbReference type="GeneID" id="41597189"/>
    <dbReference type="KEGG" id="nev:NTE_01393"/>
    <dbReference type="eggNOG" id="arCOG10172">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG10597">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_613420_0_0_2"/>
    <dbReference type="OrthoDB" id="12184at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049886">
        <property type="entry name" value="CFI_box_CTERM_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041770">
        <property type="entry name" value="CFI_box_CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="344"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="410"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="437" mass="46334" checksum="A0428F11A8134FA3" modified="2014-10-29" version="1">MRGLLAIPAIVAMLLLVIAMQYAAAAEEGNFTFHNETKYVDESKILHIYGEIKNESTTTAMKNILITASFYDATGALLSQSQQAPKLRVINPGSVAPFDMVFLDTANAGKVASYSLSARGQPTETKPASLTITSSNSRLDVLGLYYINVGIRNDGNQTVTNPIAIATLYDSAGKVVAIGEAPAESESRVVEDMAPGDRGGSGIVVSERLQTYKAASYALVADSDQYVSDVAKYKAAGPGANSGTPANGTQSGCLIATAAFESELAPQVQELRNFRDGLALKTMAGASFMNVFNGWYYSFSPHVADYEREQDWLKSTVRTSVYPLLGILDLSTSVFHALSFNNEAAIVGAGLTASSLIGLLYFAPLSAVLAIAGRKKRWDMKYAKYALVIAWAASLAAVAAGEAAASTEVLMFGTALLVLSAISTVVLAVVRVARFRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQY2</accession>
    <name>A0A075MQY2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Type-4 uracil-DNA glycosylase</fullName>
            <ecNumber evidence="3">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">NTE_01560</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="3"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987222.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQY2"/>
    <dbReference type="STRING" id="1459636.NTE_01560"/>
    <dbReference type="GeneID" id="41597342"/>
    <dbReference type="KEGG" id="nev:NTE_01560"/>
    <dbReference type="eggNOG" id="arCOG00905">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044815_1_3_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10030">
        <property type="entry name" value="UDG-F4_TTUDGA_SPO1dp_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="entry name" value="Uracil-DNA glycosylase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051536">
        <property type="entry name" value="UDG_Type-4/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005273">
        <property type="entry name" value="Ura-DNA_glyco_family4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00758">
        <property type="entry name" value="UDG_fam4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33693:SF1">
        <property type="entry name" value="TYPE-4 URACIL-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33693">
        <property type="entry name" value="TYPE-5 URACIL-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00987">
        <property type="entry name" value="UreE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="Uracil-DNA glycosylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Uracil-DNA glycosylase-like" evidence="12">
        <location>
            <begin position="44"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIF83623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="213" mass="23108" checksum="8FFE431493928700" modified="2014-10-29" version="1">MYTHRDMSSSSQKLPVTDSLEKVAAEVRGCPKCKLSRTRKNAVPGEGQLSAKVMFVGEAPGRSEDEKGRPFVGAAGRILDEMLAKAGISRSQVFITNVVKCRPPNNRVPEDDEVQACIPYLERQIALIRPRIICILGRTAYSSILGGGSITANRGKIIEKAGQKYFLTIHPAAAIYNKSMLSLLEADLKKLAKEIGAGSKAGGKRSESLEDFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MR23</accession>
    <name>A0A075MR23_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">IPT/TIG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01487</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MR23"/>
    <dbReference type="KEGG" id="nev:NTE_01487"/>
    <dbReference type="HOGENOM" id="CLU_898947_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="309" mass="30320" checksum="95CB329FC397D454" modified="2014-10-29" version="1">MFETSRHTVLAVLVGLAILSAVAAPGLIVSNAAAQTTQGNETTITPPGNETSTIPSGNETSTTTAPAGNETSAGTTTITLTPNSGGAGTNVTIAGTGFSPGQTFRFTFDNGYLLTGNMIQFATGEFNTTALVPDNATSGDHEVTVAGSMGENATATFSVVEGPANTTSSSSAAAGAPSGNETSIPSPGNETATTPGNATSLPPPNPGIGIATLVLTPTSVSTGSELNIAGTGFSNDQNVTLAIDDNTVDTNSTITTDANGAFTVAVTIPENVTAGDHQVTATDGSGVKASATLSITAAASTNMPPSPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MR27</accession>
    <name>A0A075MR27_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700389.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MR27"/>
    <dbReference type="STRING" id="1459636.NTE_01595"/>
    <dbReference type="GeneID" id="41597375"/>
    <dbReference type="KEGG" id="nev:NTE_01595"/>
    <dbReference type="eggNOG" id="arCOG10581">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1880970_0_0_2"/>
    <dbReference type="OrthoDB" id="9797at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="128" mass="14503" checksum="3559B7297B2E896D" modified="2014-10-29" version="1">MGKKAFDIFVSALVMFFFAGYLNIHSDLIGLHEPPIPVTKEVEEFWDLFSWAVFGVLAFDIALKYRQVRDPKLFVKKHWLDILMLCLMPLFAGFKAAKFSIKLVKGLKMAKSGFKAAHGAKKIGKAKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MR67</accession>
    <name>A0A075MR67_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700098.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MR67"/>
    <dbReference type="GeneID" id="41597045"/>
    <dbReference type="KEGG" id="nev:NTE_01237"/>
    <dbReference type="HOGENOM" id="CLU_2857216_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="69" mass="7753" checksum="ABAE21845B736FBC" modified="2014-10-29" version="1">MNRYLATLLIIWWAGAAVATVALFIPIYNNYVVAGSIGWGIVVVCTFLIFFEMKRVKAEDKKKENLKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRB2</accession>
    <name>A0A075MRB2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01572</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700368.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRB2"/>
    <dbReference type="GeneID" id="41597352"/>
    <dbReference type="KEGG" id="nev:NTE_01572"/>
    <dbReference type="HOGENOM" id="CLU_2712609_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="72" mass="7753" checksum="0ED9C744574A5859" modified="2014-10-29" version="1">MTSPNIAKLKEDAKDAAFGDLDDSEKAANNVTVAAKAVANKAKGAGGRDLDTKYKKIEKVTQAFDQLTFFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRK0</accession>
    <name>A0A075MRK0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01722</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRK0"/>
    <dbReference type="KEGG" id="nev:NTE_01722"/>
    <dbReference type="HOGENOM" id="CLU_904941_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="328" mass="35928" checksum="3E276A1340E81F0E" modified="2014-10-29" version="1">MPEDSASLGNVLSSSLDMLKIEDAEIRKKAVEFVGNVSLATVNAYGKWIASIKAVADACTVSGHAFSQSELCDFLTVAAKGMDSKRAGTKAVNDATFYIYMDIMENHQKAPAQLKLHFPRIIVDVISILDKGVDTRGEAVGVYGIERYYQERKASAPLEDPVASYTAAVAARPLTGGKRSSSSPSSSANNSQPNLPAITFNDDLVDNLAIITGRPKKELEASLASLPAADIKKITDLSVNYKRLQKYSKLSKPEHLKMEVEKDLGRKLTDNQLQHAANSIRKAKTYIENVLDGKFVPHGTHGINHVKHNLEYGYQLMGLIEPRKRRSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRN8</accession>
    <name>A0A075MRN8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Oligopeptide/dipeptide ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_01674</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700452.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRN8"/>
    <dbReference type="STRING" id="1459636.NTE_01674"/>
    <dbReference type="GeneID" id="41597447"/>
    <dbReference type="KEGG" id="nev:NTE_01674"/>
    <dbReference type="eggNOG" id="arCOG00181">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_2"/>
    <dbReference type="OrthoDB" id="18209at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03257">
        <property type="entry name" value="ABC_NikE_OppD_transporters"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000016">
        <property type="entry name" value="Oligopeptide ABC transporter ATP-binding component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43067:SF3">
        <property type="entry name" value="MALTOSE ABC TRANSPORTER, ATP-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43067">
        <property type="entry name" value="OLIGOPEPTIDE/DIPEPTIDE ABC TRANSPORTER, ATPASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="17"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF83735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="335" mass="36225" checksum="CCB17AACF500D9E4" modified="2014-10-29" version="1">MPSHSSSAAGESNNKKLAVKGLSAYYLTERGPVKAVDAVNFALSESESLGIVGESACGKSTLGSALMRSMQSPGRIVGGAIVLAGEDIARMSDRDFGKNVRWKKIAMVFQGAMNALDPVYTVESQLRELLQEHGFEGDVDAKISESLKQVGLAPAVASRYPHELSGGMKQRVVIAMALLLEPDLLVADEPTTALDVLVQSQIIALLKKLHREKGVTVILISHDLALVSQIADKIGIMYAGQLVEAGSTQDIYKNPKHPYTQALIAAVPRLHSDEKKIRFIPGSPPSLLDPPAGCRFYPRCPHAMDVCKQDPPEFATDTGYVRCWLYDPTLKSTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRQ4</accession>
    <name>A0A075MRQ4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01433</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700257.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRQ4"/>
    <dbReference type="STRING" id="1459636.NTE_01433"/>
    <dbReference type="GeneID" id="41597228"/>
    <dbReference type="KEGG" id="nev:NTE_01433"/>
    <dbReference type="HOGENOM" id="CLU_1763929_0_0_2"/>
    <dbReference type="OrthoDB" id="376230at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="149" mass="16148" checksum="4B0C99AC50BDDE05" modified="2014-10-29" version="1">MPGTKKQYAIAAAAGGAAAVFAIFVALAQTNAIAVPYFTPVALQVDGLKEKYAAGENASFAVTANGYGSNCHSLEVEATHNDNGERASYYNKEDDCRFMTITHGKYNFTQSFDYGSKVMGKAGMYTVDIKFKDLVDNKEARVTKTFEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRU2</accession>
    <name>A0A075MRU2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein uS17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rps17</name>
        <name evidence="8" type="ORF">NTE_01828</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700581.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRU2"/>
    <dbReference type="STRING" id="1459636.NTE_01828"/>
    <dbReference type="GeneID" id="41597593"/>
    <dbReference type="KEGG" id="nev:NTE_01828"/>
    <dbReference type="eggNOG" id="arCOG04096">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073626_0_3_2"/>
    <dbReference type="OrthoDB" id="10698at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00364">
        <property type="entry name" value="Ribosomal_uS17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01345_A">
        <property type="entry name" value="Ribosomal_uS17_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_uS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028333">
        <property type="entry name" value="Ribosomal_uS17_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019978">
        <property type="entry name" value="Ribosomal_uS17_archaeal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019979">
        <property type="entry name" value="Ribosomal_uS17_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006345">
        <property type="entry name" value="PRK08572.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03630">
        <property type="entry name" value="uS17_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744:SF9">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00973">
        <property type="entry name" value="RIBOSOMALS17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00056">
        <property type="entry name" value="RIBOSOMAL_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF83888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="113" mass="12649" checksum="4307F6502D853023" modified="2014-10-29" version="1">MVRNIGVSVIAPRKTCEDELCPFHGTLPVRGKLLTGIVASAKAKKMVVVTQEYPRPVQKYKRYERSRSKVHAYLPTCMDVKEGDEVRIAECRPLSKTVSFVVIEVNTKDGGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MS00</accession>
    <name>A0A075MS00_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NTE_01820</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700575.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MS00"/>
    <dbReference type="STRING" id="1459636.NTE_01820"/>
    <dbReference type="GeneID" id="41597585"/>
    <dbReference type="KEGG" id="nev:NTE_01820"/>
    <dbReference type="eggNOG" id="arCOG02358">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015921_0_0_2"/>
    <dbReference type="OrthoDB" id="342253at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00075">
        <property type="entry name" value="HATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000006">
        <property type="entry name" value="Sensor histidine kinase WalK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050736">
        <property type="entry name" value="Sensor_HK_Regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43711:SF1">
        <property type="entry name" value="HISTIDINE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43711">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="342"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="308"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF83880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="555" mass="62243" checksum="9394313F5C55222D" modified="2014-10-29" version="1">MSNAPSNPQTKVFYGTEETTAAIIAFLNNTHSTMSICADSTWPSVVMGIEIFKTQFHALKDRNVKSRFITNITKENLPYCKEVMQLGELRHMDGVKGGMGVTETEFMATAVLQEAQLLSQVIYSNVKEVIEQQQYLFEALWSKAIPASRRIREIEDGIQTETIELIHSPSKSLSMYKDLISEARREILVVIPTINAVRRQDRAGIFKLISEAARDRHVEVRILMPKHQSSKELSRRLKDDKNLTIRFFEQFEGSKSTFLIVDRSVSLVIELIDDSKERFEEAGGFSTYSTSTPGILSYVFVFENLWLQTELSKKLKESNEQLETANEQLELRDKMLNEFISVAAHEIRNRVAPILLTAEGIEGQEEDKERVEIILRNARRLQGLLQDVLDVTKIDNQTLKLNKEKFDLTELAEGLVNDAKRQSKNDRLQLLCEGSKGTTSAFADRGRIMQVLANLVGNAINYTKEGTISVSVKKEGSVFVVSVKDEGTGIAANIFPRLFSKFATGSSQGTGLGLYISKSIIEAHGGKIWAENNSNGRGATFTFTLPAQDLEIANK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MS28</accession>
    <name>A0A075MS28_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_02267</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700916.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MS28"/>
    <dbReference type="STRING" id="1459636.NTE_02267"/>
    <dbReference type="GeneID" id="41597982"/>
    <dbReference type="KEGG" id="nev:NTE_02267"/>
    <dbReference type="eggNOG" id="arCOG00235">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028458_3_1_2"/>
    <dbReference type="OrthoDB" id="6242at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000002">
        <property type="entry name" value="2-hydroxyhepta-2,4-diene-1,7-dioate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051121">
        <property type="entry name" value="FAH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42796:SF4">
        <property type="entry name" value="FUMARYLACETOACETATE HYDROLASE DOMAIN-CONTAINING PROTEIN 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42796">
        <property type="entry name" value="FUMARYLACETOACETATE HYDROLASE DOMAIN-CONTAINING PROTEIN 2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="82"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF84321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="289" mass="32613" checksum="E9C952683F2B9D67" modified="2014-10-29" version="1">MKIARINDSKFQETYALVSDDGKHLVTRQEIQEQTGIPVPPSIKDFMFNGWLDEVRKAKDRLTYKHRVEEAELLVPIPNPPKIVCLAFNYYDHARDAGLTPSDEPVIFLKPRTALNKPYGEVHCPSFVTRLDYEAELAVVIGKQAKKLSEEDALDCVFGYMIFHDVSARDIQFKDKQFTRGKGIDTFAPCGPWITTKDEVPDPQNLMITTKVNSETRQNSSSSNMVLSIRRIISGLTRTMTLEPGDIISTGTPAGVAMSMKEPRYLKNGDVVEIAIERLGVIRHKIIFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MS38</accession>
    <name>A0A075MS38_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mn2+-dependent serine/threonine protein kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02283</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700930.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MS38"/>
    <dbReference type="STRING" id="1459636.NTE_02283"/>
    <dbReference type="GeneID" id="41597998"/>
    <dbReference type="KEGG" id="nev:NTE_02283"/>
    <dbReference type="eggNOG" id="arCOG01185">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1145252_0_0_2"/>
    <dbReference type="OrthoDB" id="10402at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="233" mass="26004" checksum="FF460D731B1051A2" modified="2014-10-29" version="1">MYFVNWQRDISVEERDGRKVVVKRNKPTKGFHEYILLCTYTFISIFLAHPSAPPAPGDITRNEGPETRKTLERVGIPTPHLVSMTGKELVEEYVDGGDLYRSLAAGTRRSSLAQEAGRLTALAHTAGLVFTDNKAQNFLVQGESLLRTDLAFLQKSRSTFARSMDVGSFLASVVDLPNYREIEQAFYRGYRLQSGDNFPYLSLVIRNILATGFSADGRTALRNMMLDSSDVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSC7</accession>
    <name>A0A075MSC7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase (GNAT) domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSC7"/>
    <dbReference type="STRING" id="1459636.NTE_01646"/>
    <dbReference type="KEGG" id="nev:NTE_01646"/>
    <dbReference type="eggNOG" id="arCOG05161">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1182907_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="99"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="237" mass="26643" checksum="67621AB95D520BFC" modified="2014-10-29" version="1">MEENEWAFCSLWSKKIEIKCATALVNPKLEGDYFFNRATVENCNVPYEQVAQVFWDAGIDCHLYFRSQPPPRLRMVDTMYVLRAAKKKAGEPRDSRRIKITAACKPSEVAIWIDVFCRSFSVPEWKDEVARIITSNAKKLELLRAYNNENNMPAGCGALFTTKNNSMTGLYCLGTVPAQRSKGVAKSILNFARALAEKQGTLLFLQTLGSENLLGLYKSSGFETAYTKTICAVPRIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSD0</accession>
    <name>A0A075MSD0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01962</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385307.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSD0"/>
    <dbReference type="STRING" id="1459636.NTE_01962"/>
    <dbReference type="GeneID" id="41597710"/>
    <dbReference type="KEGG" id="nev:NTE_01962"/>
    <dbReference type="eggNOG" id="arCOG08680">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2204200_0_0_2"/>
    <dbReference type="OrthoDB" id="10998at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="122" mass="13654" checksum="0591AF8550016276" modified="2014-10-29" version="1">MVRFFRTNDVKTAYIMSYEPDDGGGGMFARTSGKRLAILFGLAFFGAFMLIQVVQGFPLRDILIREKITEERAIAIKQGDLCVIDTPDHPREIKNCPYNVGDRVIVTYSKNNAAIEAHRLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSH5</accession>
    <name>A0A075MSH5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Universal stress protein UspA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_02018</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700722.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSH5"/>
    <dbReference type="STRING" id="1459636.NTE_02018"/>
    <dbReference type="GeneID" id="41597763"/>
    <dbReference type="KEGG" id="nev:NTE_02018"/>
    <dbReference type="eggNOG" id="arCOG02053">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049301_16_2_2"/>
    <dbReference type="OrthoDB" id="105697at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00293">
        <property type="entry name" value="USP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46268">
        <property type="entry name" value="STRESS RESPONSE PROTEIN NHAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46268:SF25">
        <property type="entry name" value="USPA DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006276">
        <property type="entry name" value="UspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UspA" evidence="2">
        <location>
            <begin position="3"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF84075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="142" mass="15080" checksum="8BD8C8B692CF9134" modified="2014-10-29" version="1">MPSKILVPVDGSKYSKKALEQALSIAKGTGASVTVIHVIETPPTVYVESQKVLDSAMAKYKSESARMLDEYKAAAEELGFRIDTAIVAEGDPAASIVAFCEKGGFDMIAMGSRGHGKLKEMVLGSTTSKVLRQAKCSVLIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSI6</accession>
    <name>A0A075MSI6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00227</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699321.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSI6"/>
    <dbReference type="STRING" id="1459636.NTE_00227"/>
    <dbReference type="GeneID" id="41596147"/>
    <dbReference type="KEGG" id="nev:NTE_00227"/>
    <dbReference type="HOGENOM" id="CLU_1197599_0_0_2"/>
    <dbReference type="OrthoDB" id="386207at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="231" mass="26179" checksum="9E75FAFC65EF80AA" modified="2014-10-29" version="1">MKDAIVSSNAPSLSLSSSLSSQQQAAPVIVNSSSTTNSTDVPTRALYPFFPKGLEPDHEHVILGLEVSVPATNIVFKRWKGKPIKDDMAGKPVVEYEGKPMFAELAIVKMAVRSGWSAFWQKAYPVRQSGPYYYSEWREDVPRKDQVTSSSLNSAYQEQVQASIARYNGNSFRGCWEVIAWNKGRTLYMKSMQSKKDTIRDNQVRWFSASLSAGLRRKENFLVVNWQFEDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSJ0</accession>
    <name>A0A075MSJ0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00232</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSJ0"/>
    <dbReference type="STRING" id="1459636.NTE_00232"/>
    <dbReference type="KEGG" id="nev:NTE_00232"/>
    <dbReference type="HOGENOM" id="CLU_3362467_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="35" mass="3992" checksum="EFD2D341119FB744" modified="2014-10-29" version="1">MYTEDKVKAAAKCSTIPQNRLDLDSDADAFRKKNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSJ9</accession>
    <name>A0A075MSJ9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ODP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700763.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSJ9"/>
    <dbReference type="GeneID" id="41597811"/>
    <dbReference type="KEGG" id="nev:NTE_02077"/>
    <dbReference type="eggNOG" id="arCOG00509">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100517_0_0_2"/>
    <dbReference type="OrthoDB" id="6433at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045761">
        <property type="entry name" value="ODP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43717">
        <property type="entry name" value="ANAEROBIC NITRIC OXIDE REDUCTASE FLAVORUBREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43717:SF1">
        <property type="entry name" value="ANAEROBIC NITRIC OXIDE REDUCTASE FLAVORUBREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19583">
        <property type="entry name" value="ODP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ODP" evidence="1">
        <location>
            <begin position="38"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="257" mass="29085" checksum="24B27A489D186998" modified="2014-10-29" version="1">MPEVSKTFRVAKDTTASISEITDGIYRISGFVNEYGITFNQFLINDEKPTLIHTGPVGMYEGVAEKVKEVIPLEKLAYVAFLHFESDEWGGMEFLKSPDVKLLCSDLSSRLNLMGWDGVPVHHISFWDSEVLKTGRRSLRFLMTPHVHHWDSMMIFEDTTKSLFPSDLFIQPGDNKPVISDDLSKEMIQLYRGAGIFASEIPVRQTAQRLLKMGPKMTFPMHGSCIDQGSFTRYVDALMNNEFAYSGMLLGQKLEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSK2</accession>
    <name>A0A075MSK2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oligoketide cyclase/lipid transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02507</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701110.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSK2"/>
    <dbReference type="STRING" id="1459636.NTE_02507"/>
    <dbReference type="GeneID" id="41598211"/>
    <dbReference type="KEGG" id="nev:NTE_02507"/>
    <dbReference type="eggNOG" id="arCOG05400">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131895_0_0_2"/>
    <dbReference type="OrthoDB" id="7914at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="139" mass="15211" checksum="8C70BD8F578A76CF" modified="2014-10-29" version="1">MPTINVSREIGAPLDRVWSIISDVDNEAQYWHGTKSVRNISKNDNVIQREVVIAFKDAKTMQTVTLNPMTSIDTRITEGPITGSRIVTLNSVGGGDKTKVDVTWDFKLAGLLSVFGGMVKKHIAEGTEQALERIAKAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSS4</accession>
    <name>A0A075MSS4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700816.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSS4"/>
    <dbReference type="STRING" id="1459636.NTE_02146"/>
    <dbReference type="GeneID" id="41597871"/>
    <dbReference type="KEGG" id="nev:NTE_02146"/>
    <dbReference type="HOGENOM" id="CLU_670173_0_0_2"/>
    <dbReference type="OrthoDB" id="132546at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase subfamily 4-like N-terminal" evidence="1">
        <location>
            <begin position="64"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="408" mass="46556" checksum="CDE9FF2102723FED" modified="2014-10-29" version="1">MRILHLSHDGLPDWRVEKSALTSSKQGYEVFFAGKKIADGYDATKVFSQAYEINWTAKALCGMPYYWHSVRNQLAKVIKQVRPDMVHAHNLFSAKLVQDLGERFVYDDHESWSKHSLLLSEMEEAVQQQEAQQYVSNASSGGSLVHSIMSMAARTKRSAVNRRTTGLWAKWEKEVLDSSAATITVSNRIAKELRLASGSGSSSRIVVVPNYPTKQETSDLEKPRYLDRLSSVYSGSDGQSNGSRRLPNRNMDGLYDLFNNDSSSSNKNTGTLTILGWQGTTTDPSSRVEFAGFLSRKEMFKEMSNHSIGLLPWKRHWSHYFVNPNKVYEYAHAGLHVMCTSSFDTVIETFQGNCTTFDDYKDLASQLEYYDENMEELYKKRVKTYEFAHSNLVWENFEPEILRAYQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MST2</accession>
    <name>A0A075MST2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01781</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700540.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MST2"/>
    <dbReference type="STRING" id="1459636.NTE_01781"/>
    <dbReference type="GeneID" id="41597547"/>
    <dbReference type="KEGG" id="nev:NTE_01781"/>
    <dbReference type="HOGENOM" id="CLU_1998650_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033496">
        <property type="entry name" value="DUF2080_fam_acc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="124" mass="14645" checksum="D314AFB87B836B81" modified="2014-10-29" version="1">MSELEITQQRLFLNEAKARHRDLITWQERNEFFIKNHPDLPGWVRSRGYKHIISEIEKHYRYDLIRYLFKEGRTITRTKQHADKSTPKEIVATATAIGGGAHVYVPKQWMGKRLKIIVEEAANE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSU3</accession>
    <name>A0A075MSU3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01796</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSU3"/>
    <dbReference type="STRING" id="1459636.NTE_01796"/>
    <dbReference type="KEGG" id="nev:NTE_01796"/>
    <dbReference type="HOGENOM" id="CLU_2392748_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="93" mass="10601" checksum="5BD1DECCA8A96075" modified="2014-10-29" version="1">MTLAHDFFCGLGQCWIGDLVDGVWQFGSVLLQYAVPLMQVFALFYLLYWVGLIIRVVRQGDIAPVVDHVMKIWHLLSSIANMFVNMIQAVIPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSU5</accession>
    <name>A0A075MSU5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative snRNP Sm-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_02161</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015019730.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSU5"/>
    <dbReference type="STRING" id="1459636.NTE_02161"/>
    <dbReference type="GeneID" id="41597885"/>
    <dbReference type="KEGG" id="nev:NTE_02161"/>
    <dbReference type="eggNOG" id="arCOG00998">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076902_11_1_2"/>
    <dbReference type="OrthoDB" id="371816at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01731">
        <property type="entry name" value="archaeal_Sm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044641">
        <property type="entry name" value="Lsm7/SmG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022901">
        <property type="entry name" value="snRNP_Sm-like_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553:SF5">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Sm" evidence="4">
        <location>
            <begin position="5"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF84215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="76" mass="8220" checksum="54CB4079691359E2" modified="2014-10-29" version="1">MSVDMAVKVLDESLGKVVLIKLKGGKVIRGNLHGFDQHMNLLLEDSVEILEEGKSNDLGTIVVRGDNVVIISPPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSY3</accession>
    <name>A0A075MSY3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02241</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSY3"/>
    <dbReference type="KEGG" id="nev:NTE_02241"/>
    <dbReference type="eggNOG" id="arCOG04668">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1088211_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046666">
        <property type="entry name" value="DUF6775"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20565">
        <property type="entry name" value="DUF6775"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="246" mass="28379" checksum="30A58C4BF3CDB12E" modified="2014-10-29" version="1">MLDFHRVHFYPEPSSSSGIDLDRIISDVAQVFTNCILDVCKPFFFEHHRIDIERARVSEIKQPFERQPKEHQDFDLYGRPTALYDGFELQRILAPAFQTDVHIIFTDLLTCTFSEDDWRYHARAVICGTPSIISTTGIVEAPAKPREFYISQFGADINSLKKKLAGRFIDYGDKRMTEVAAGYVLQALFFFVADGEPFCESDACRLYNAHWQEDLIRTQVENPMLCLKHRSLANKFNRRLAAKGMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MT12</accession>
    <name>A0A075MT12_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01872</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MT12"/>
    <dbReference type="STRING" id="1459636.NTE_01872"/>
    <dbReference type="KEGG" id="nev:NTE_01872"/>
    <dbReference type="eggNOG" id="arCOG04291">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2010008_0_0_2"/>
    <dbReference type="OrthoDB" id="35747at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.410">
        <property type="entry name" value="Protein of unknown function UPF0759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002763">
        <property type="entry name" value="DUF72"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036520">
        <property type="entry name" value="UPF0759_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01904">
        <property type="entry name" value="DUF72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117396">
        <property type="entry name" value="TM1631-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="123" mass="14334" checksum="E56E00D62CDD503D" modified="2014-10-29" version="1">MEIYILNKQYRYAVEIRHPSWFNDELYDFLKRKGICLVWNQLDDIKAPPIVTTDFIYLRLIGDRSISEHEFGRIQKDRVPEMELLAQEVKKATATGALGGSQPASDCIRYSCLNHHMQSTFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MT79</accession>
    <name>A0A075MT79_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hydrolase or acyltransferase of alpha/beta superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00442</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158384984.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MT79"/>
    <dbReference type="STRING" id="1459636.NTE_00442"/>
    <dbReference type="GeneID" id="41596318"/>
    <dbReference type="KEGG" id="nev:NTE_00442"/>
    <dbReference type="eggNOG" id="arCOG01648">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG07416">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_13_4_2"/>
    <dbReference type="OrthoDB" id="9890at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46438">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="31"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="275" mass="29945" checksum="CE4E2B31462811E9" modified="2014-10-29" version="1">MMMALAMDFKFLQVGGLRVRYVDLGNSGSRPLLLLHGLGGAIESWTNNIDRLAKEENLRVVALDLPGFGFSDKPKMRYTIKFYVDFVAKFAKALDIAPFAVAGSSLGGHVACELALTHPDLVSKLILISPSGALPKSFKGSPALWRYVKVLKAKSVGGAKKALYAVDNKPVSDAYAKAAYDKFAMPGAKEAFLSALAGSARAPRLTISRLSKIRAPALVLWGKDDTMIPAKYVEPFVKTKNIRVVLLENCGHRPHVDRPQLFDKIVADFVKENDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTA3</accession>
    <name>A0A075MTA3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13 14">Multifunctional fusion protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="13">DNA-directed RNA polymerase subunit Rpo1C</fullName>
                <ecNumber evidence="13">2.7.7.6</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="13">DNA-directed RNA polymerase subunit A''</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="14">DNA-directed RNA polymerase subunit Rpo1N</fullName>
            </recommendedName>
            <alternativeName>
                <fullName evidence="14">DNA-directed RNA polymerase subunit A'</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="13" type="primary">rpo1C</name>
        <name evidence="14" type="synonym">rpo1N</name>
        <name evidence="14" type="synonym">rpoA1</name>
        <name evidence="13" type="synonym">rpoA2</name>
        <name evidence="17" type="ORF">NTE_02749</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms part of the jaw domain.</text>
    </comment>
    <comment type="function">
        <text evidence="12 14">DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms the clamp head domain.</text>
    </comment>
    <comment type="function">
        <text evidence="15">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 14 15">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14">Binds at least 2 Zn(2+) per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Part of the RNA polymerase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 13 15">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="13"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701304.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTA3"/>
    <dbReference type="STRING" id="1459636.NTE_02749"/>
    <dbReference type="GeneID" id="41598438"/>
    <dbReference type="KEGG" id="nev:NTE_02749"/>
    <dbReference type="eggNOG" id="arCOG04256">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG04257">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000487_3_1_2"/>
    <dbReference type="OrthoDB" id="371812at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06528">
        <property type="entry name" value="RNAP_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02582">
        <property type="entry name" value="RNAP_archeal_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00411">
        <property type="entry name" value="RNApol_arch_Rpo1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00863">
        <property type="entry name" value="RNApol_arch_Rpo1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
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        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
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        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
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        <property type="entry name" value="RNA_pol_Rpb1_5"/>
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    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
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        <property type="entry name" value="Rpb1_funnel_sf"/>
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        <property type="entry name" value="RPO1C"/>
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    <dbReference type="InterPro" id="IPR012758">
        <property type="entry name" value="RPO1N"/>
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    <dbReference type="NCBIfam" id="NF006336">
        <property type="entry name" value="PRK08566.1"/>
        <property type="match status" value="1"/>
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    <dbReference type="NCBIfam" id="TIGR02390">
        <property type="entry name" value="RNA_pol_rpoA1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNA_pol_rpoA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376:SF32">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC1"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 13 15" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="8 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 13 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 13 15" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 13 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="16">
        <location>
            <begin position="208"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
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    <feature type="binding site" evidence="14">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
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    <feature type="binding site" evidence="14">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
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        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="459"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="461"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
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    <feature type="binding site" evidence="14">
        <location>
            <position position="463"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
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    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00006460"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00053389"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="HAMAP-Rule" id="MF_00411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AIF84791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="1269" mass="141061" checksum="5B537737A828CB07" modified="2014-10-29" version="1">MMEESAKILGGIKFSVWSPTEVRKFSVAEVTAPETYDEDGMPVQGGLMDNRLGTLEPGQKCATCGNTSAKCPGHFGHIELAEPVLHIAFVDDVHKLLLTTCRSCNRIKLDPEELAHYKAIRESKAPYAVITLENIRDEIIEKAKKVKSCPHCGKEQYDLIFTKPTIFVERTEAGENRLLPITIRERLSHVPDEDLMLLGYDPTTARPEWFVLQVLPVPPVTVRPSIILETGIRSEDDLTHKLVDIIRVNQRLKESKEAGTPPLIVQDLVDLLQYHVTTYFDNEVSGIPQAHHRSGRPLKTLTQRLKGKEGRFRGSLSGKRVDFSSRTVISPDPNLTISNVGVPTDVAKKLTIPETVSQWNLEKLKALVTNGPNTYPGANYIIRPDGVKIRLDYVTDRKTIADSLAPGYIVERHLSDGDIVIFNRQPSLHRMSIMAHSVVVLPYRTFRLHPAVCPPYNADFDGDEMNLHVPQSEEARAEATLLMRVQDQLISPRYGGPIIGGIRDFITGAFMLTRDETVLTRDEFANLALVGGYRGPLPEPAVATKDGQKLYSGRQLFSLFLPKDFNFVITSKWNKAAKGEGRDVVIKNGQLISGVIDKASIGAEEPDSVLHRIAKDYGTDVARKFLDSILIMLKTYITHRGFTYGYSDLWLSPETRQEISDIIQKTYDKVHELIQQYRDGSLPLTRGLSAEEALELYVVNELSRARDRAGRTADRAFPDNNSGIIMASTGARGSTLNIGQMTAALGQQSIRGKRIQKGYRNRALPHYIPNETSPDARGFVKSNYRDGLSPLEFFFHAMGGREGLVDTAVRTQQSGYMQRRLINALEHLKIEYDQTVRDPHGNIVQYLYGEDGIDPAKSDHGEAVNISRLIEAEAIVDEGRKATEEAIKKIIEEHGASLNPRMRASLEKALLENKLSREGVEKVMRKVVDLVDRALAEPGEAIGVVTAQSIGEPGTQMTLRTFHFAGVKERNVTLGLPRLIELVDARKKPVTPTMDIYLDEAHRGSREKALEVAREILFTQVGDLIEKSETDYSGVLTFYFSEAKLAERGCTLEEANAVLEGTKKKYEVKMNEGKRSIKVTVPDEPDAQTLLTLKNKLLNTRVKGVPDIERVTIVKQDEEWVIQTAGSNLAKVVLVDGVDTSRIATNNVYEIWQTLGIEAARTALVKEITNTLEEQGLEVDVRHIMLVADLMTSKGYLQQIGRHGIAGTKTSVLARAAFEITVPTIARASLEGQVETLRGVTENVIVGATVPVGTGMVDLYMKVKEGKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTB9</accession>
    <name>A0A075MTB9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701325.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTB9"/>
    <dbReference type="STRING" id="1459636.NTE_02775"/>
    <dbReference type="GeneID" id="41598464"/>
    <dbReference type="KEGG" id="nev:NTE_02775"/>
    <dbReference type="eggNOG" id="arCOG10597">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1105172_0_0_2"/>
    <dbReference type="OrthoDB" id="12184at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049886">
        <property type="entry name" value="CFI_box_CTERM_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041770">
        <property type="entry name" value="CFI_box_CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="251" mass="25985" checksum="F6B0399CB373C6D4" modified="2014-10-29" version="1">MRKTAFYGVALATFVAVSLALLLLLPTLPAMAEEGDSLGFGDNVSAQVKRANNQTGTVQPARQPSGCLIATAAFGSELTPQVQFLRGFRDNHILSTAAGSSFMNVFNGWYYSFSPSVADYERANPWAQATIKTAIYPLLGILQVAEKGYGMSAGEGGAVVAGFAASALIGAVYLSPAAVALRNRAPGKKLLMALGISAIASLAAVAAGVAAGNAIVLMASTALFVLSSIGVGLFAVMTLAKKIEEKQQHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTI6</accession>
    <name>A0A075MTI6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Phosphomethylpyrimidine kinase</fullName>
            <ecNumber evidence="7">2.7.1.49</ecNumber>
            <ecNumber evidence="7">2.7.4.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NTE_02040</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.49" evidence="7"/>
    <dbReference type="EC" id="2.7.4.7" evidence="7"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700736.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTI6"/>
    <dbReference type="STRING" id="1459636.NTE_02040"/>
    <dbReference type="GeneID" id="41597780"/>
    <dbReference type="KEGG" id="nev:NTE_02040"/>
    <dbReference type="eggNOG" id="arCOG00020">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG00021">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035788_0_0_2"/>
    <dbReference type="OrthoDB" id="43786at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008902">
        <property type="term" value="F:hydroxymethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008972">
        <property type="term" value="F:phosphomethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01169">
        <property type="entry name" value="HMPP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.20:FF:000003">
        <property type="entry name" value="Phosphomethylpyrimidine kinase ThiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004399">
        <property type="entry name" value="HMP/HMP-P_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019293">
        <property type="entry name" value="ThiN"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00097">
        <property type="entry name" value="HMP-P_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20858:SF17">
        <property type="entry name" value="HYDROXYMETHYLPYRIMIDINE_PHOSPHOMETHYLPYRIMIDINE KINASE THI20-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20858">
        <property type="entry name" value="PHOSPHOMETHYLPYRIMIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyridoxamine kinase/Phosphomethylpyrimidine kinase" evidence="5">
        <location>
            <begin position="14"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine-phosphate synthase ThiN" evidence="6">
        <location>
            <begin position="276"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF84097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="450" mass="47916" checksum="8E1D4E512718508D" modified="2014-10-29" version="1">MTTTKVALSIAGSDSGAGAGIQADLKTFSALGVYGCTAITALTAQNTEKVAKIHEVPADIVEAQVTSIMADMPPAVIKVGMVYSRQVIDAVAKPLRKAKAPIVLDPILAAGTGAKLLKDDALDSFVSRLIPLATLVTPNRMEAEKLSGVTIRNEGGDGIEAAKKLKALGARNVIVKGGHFGKKTVTDILLLDDNKVVEITNPRVDIKESHGSGCNFSAAVTAYLARGMALEEACRMANEYVHDAIKNAVAVGRGLPVTNPLSSIYKDAMRHRVLAELQAAVDRLVSLDGLYRLIPETQTNFAYALPDAANHSEVAAVRGRMARAGNAVVQVSRVEFGASRHMASAVLAYMSIRPATRAVANIRFGQEVLAACKTLFKEQVSSYDRSKEPADVKKKEGSTISWGTRAALAKNPKAEVIYHKGDVGKEPMITVFGRSPAEVVYKIEQILKIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTS0</accession>
    <name>A0A075MTS0_9ARCH</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">NTE_02107</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTS0"/>
    <dbReference type="STRING" id="1459636.NTE_02107"/>
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    <dbReference type="HOGENOM" id="CLU_2230259_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="105" mass="11553" checksum="35AB87B043C5F038" modified="2014-10-29" version="1">MTPEQEGEMLQLLRGISTKLSILTDTSPFARMSKAEIERAVDLKLETVSLGEVCEVTGKQADSGTNIGEVARAIEDKKRDDFERNYEARAEAIAKAAKEIGVIIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTS8</accession>
    <name>A0A075MTS8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nitrososphaera output domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_02499</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTS8"/>
    <dbReference type="KEGG" id="nev:NTE_02499"/>
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    <dbReference type="InterPro" id="IPR041226">
        <property type="entry name" value="NitrOD2"/>
    </dbReference>
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    </dbReference>
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    <feature type="domain" description="Nitrososphaera output" evidence="2">
        <location>
            <begin position="25"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF84548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="128" mass="14458" checksum="0667A83C6AD8BC8F" modified="2014-10-29" version="1">MFVSLYSDTPPMESKPHRGQRRQQQAIADAILANIKEIFGWNVYDMMTRKIMENYLNNKIDIRTAIVEHPAVFERAFIGLIGPLGEKFLADVCEKVQSELDLDQSTRYSKAGDLAKYIRTASNSSSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTU8</accession>
    <name>A0A075MTU8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02519</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
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            <taxon>Nitrososphaerota</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_264357909.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTU8"/>
    <dbReference type="STRING" id="1459636.NTE_02519"/>
    <dbReference type="GeneID" id="75933631"/>
    <dbReference type="KEGG" id="nev:NTE_02519"/>
    <dbReference type="HOGENOM" id="CLU_210695_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="43" mass="4968" checksum="BED9FFC8EECE8723" modified="2014-10-29" version="1">MFEASPFVVIFQYAFIAAFPLVGLAVVTKWVFDDWKKSRRTQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTX7</accession>
    <name>A0A075MTX7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02153</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTX7"/>
    <dbReference type="STRING" id="1459636.NTE_02153"/>
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    <dbReference type="HOGENOM" id="CLU_145173_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="128" mass="14846" checksum="6245942AE4342EFB" modified="2014-10-29" version="1">MDEIIYQLNKTKRMFIMMIITIIVIVPVSIVAIFATFGPIGGRGGGWWWHDGVGGGPPTFSPAFDAVRLLITVVVLVWLVLGIRQWFILSKWTKKYETYKELQKKIEDKLDFEKDDDEEREEGRDNNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTY9</accession>
    <name>A0A075MTY9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CRISPR-associated protein Cas5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
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        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701158.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTY9"/>
    <dbReference type="STRING" id="1459636.NTE_02574"/>
    <dbReference type="GeneID" id="41598269"/>
    <dbReference type="KEGG" id="nev:NTE_02574"/>
    <dbReference type="eggNOG" id="arCOG02758">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1113831_0_0_2"/>
    <dbReference type="OrthoDB" id="42959at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021124">
        <property type="entry name" value="CRISPR-assoc_prot_Cas5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013422">
        <property type="entry name" value="CRISPR-assoc_prot_Cas5_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02593">
        <property type="entry name" value="CRISPR_cas5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09704">
        <property type="entry name" value="Cas_Cas5d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="249" mass="28526" checksum="3E89A6F42EAEF288" modified="2014-10-29" version="1">MLNSIVSFCISGEFAAFRDPSVTSNQTVYYIPSKSAVIGLLGAILGVERDHSLGEIYGGDYIKLFKKTKIGMELESDPRKISFFTNHRSLKEPKTKPFKTEVLVSPSYRIYVKTDDSIMDTLYAALKENDFKYPPYLGHAYCPARISDAKMQEIAVFDGRKFETSSVILDESETYNTRFSVTAEPVNDNSRIIIERHLHHFFENEKLERRVLRHWIPARGSAYEVRISEKPKLSSYYSLQDGGKVVCFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MU11</accession>
    <name>A0A075MU11_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03122</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701601.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MU11"/>
    <dbReference type="STRING" id="1459636.NTE_03122"/>
    <dbReference type="GeneID" id="41598782"/>
    <dbReference type="KEGG" id="nev:NTE_03122"/>
    <dbReference type="eggNOG" id="arCOG04331">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119426_0_1_2"/>
    <dbReference type="OrthoDB" id="359228at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025540">
        <property type="entry name" value="FlK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054485">
        <property type="entry name" value="FlK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36934">
        <property type="entry name" value="BLR0278 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36934:SF1">
        <property type="entry name" value="THIOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22636">
        <property type="entry name" value="FlK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF014972">
        <property type="entry name" value="FlK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fluoroacetyl-CoA-specific thioesterase-like" evidence="1">
        <location>
            <begin position="21"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="140" mass="15770" checksum="D83F15CBA72A7491" modified="2014-10-29" version="1">MSIDFGSRVRVGAVKERTITVDSNMTTSFLWEGENVLSTPAMIMEMEETCRLLLKEQAIPEAEWDSVGTIVDIRHLAATPVGAQVFLKAKVTSVNGRQVMFEVEASDRLEKIGEGRHERFIINVPRFRAKFGEKQKQLGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MU28</accession>
    <name>A0A075MU28_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription initiation factor IIB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NTE_02637</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TFIIB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_075054465.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MU28"/>
    <dbReference type="STRING" id="1459636.NTE_02637"/>
    <dbReference type="GeneID" id="41598330"/>
    <dbReference type="KEGG" id="nev:NTE_02637"/>
    <dbReference type="eggNOG" id="arCOG01981">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043736_0_1_2"/>
    <dbReference type="OrthoDB" id="7429at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20550">
        <property type="entry name" value="CYCLIN_TFIIB_archaea_like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000023">
        <property type="entry name" value="Transcription initiation factor IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.170:FF:000001">
        <property type="entry name" value="Transcription initiation factor IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023486">
        <property type="entry name" value="TFIIB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618:SF13">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="Zn_Ribbon_TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00782">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Cyclin-like" evidence="7">
        <location>
            <begin position="119"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="7">
        <location>
            <begin position="213"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00053882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF84680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="301" mass="33520" checksum="FDD0A865CA450F61" modified="2014-10-29" version="1">MKTSLVSPCKHEKTVTDPESGEIICRSCGLVISDKIQEMRPEWRAFTSQEADDRARTGIPSSLARHDMGLSTVIARTDKDASGRLIEGVMKSTMDRLRAWDFRTQAHSPTDRNLRQAFSELDRLKDKLSLSDAVVEKTAYIYRKAQERGLVRGRTISATLGAALYIAIRETGMSRTLKDIAETSNVKRKDLARMYRLVVLELDLKIPMIDPMKCIARVASKSGLSEKTKRHAMNIMYDVVKSGMSAGKDPMGLAASVLYMASLETGENRTQTDIAEAAGVTEVTVRNRYKNLKSRLDSLAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MU62</accession>
    <name>A0A075MU62_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Signal recognition particle 54 kDa protein</fullName>
            <shortName evidence="10">SRP54</shortName>
            <ecNumber evidence="10">3.6.5.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">srp54</name>
        <name evidence="14" type="ORF">NTE_00776</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.4"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9 10">Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="10">The SRP-RNC complex is targeted to the cytoplasmic membrane.</text>
    </comment>
    <comment type="domain">
        <text evidence="10">Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the GTP-binding SRP family. SRP54 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.4" evidence="10"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699743.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MU62"/>
    <dbReference type="STRING" id="1459636.NTE_00776"/>
    <dbReference type="GeneID" id="41596627"/>
    <dbReference type="KEGG" id="nev:NTE_00776"/>
    <dbReference type="eggNOG" id="arCOG01228">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009301_6_0_2"/>
    <dbReference type="OrthoDB" id="52849at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048500">
        <property type="term" value="C:signal recognition particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17875">
        <property type="entry name" value="SRP54_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000022">
        <property type="entry name" value="Signal recognition particle 54 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="entry name" value="Signal recognition particle SRP54, nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.30">
        <property type="entry name" value="Signal recognition particle, SRP54 subunit, M-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00306">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036891">
        <property type="entry name" value="Signal_recog_part_SRP54_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004125">
        <property type="entry name" value="Signal_recog_particle_SRP54_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 54K PROTEIN SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564:SF5">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02978">
        <property type="entry name" value="SRP_SPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="Domain of the SRP/SRP receptor G-proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47446">
        <property type="entry name" value="Signal peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 10" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="Signal recognition particle SRP54 helical bundle" evidence="13">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="115"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="SRP54-type proteins GTP-binding" evidence="12">
        <location>
            <begin position="116"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="123"/>
            <end position="130"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="205"/>
            <end position="209"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="263"/>
            <end position="266"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00064051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AIF82854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="457" mass="50173" checksum="D53F89C1312C2923" modified="2014-10-29" version="1">MFDNLRDGLRSALKKIVGASDINEELIDSLCKDIQRSLLLSDVKAGLVKTITDNLKQRALTEQPPKGLSRKDHIVTILYGELARMLGYSGEVITTIDKKGIDDDPGVTAFFKPGKQNVVLLLGIQGSGKTTVTAKLARWLTRHGYRVGVVGTDTWRPGALTQLKMNCAKINVEVYGEEESKDAVGIARHGLEHFKPQNLDVIIIDTAGRHKEEAGLLQEMAEMHKASTPDLALLVLDGTIGQQAYSQAEAFHKAAPLGGIIITKLDGTAKGGGALAASAATGAKVMFIGTGERIDDLEQFSPTRFVGRLLGMGDIKALLEMAKGLEMQADENQAKRVLSGKMTIEDFYAQMEQVSKIGFRNVIENMPGLSGMVKEDQLDAMQARMEKWRFIIQSMTKDEKKDPDLINEARRKRIARGSGMPESEVKHMITQYNNSKAMMKQSKGRQMQGLMRKFGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MU70</accession>
    <name>A0A075MU70_9ARCH</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02208</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MU70"/>
    <dbReference type="STRING" id="1459636.NTE_02208"/>
    <dbReference type="KEGG" id="nev:NTE_02208"/>
    <dbReference type="HOGENOM" id="CLU_2802397_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="74" mass="8279" checksum="7119001C52F5EDC0" modified="2014-10-29" version="1">MLSVTTAIDELKALLHKGCKVQKVQPAVFASDAEVNIVIVTVACPDGRIHTVKAYREEAKELREFTRKQQTLQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MU93</accession>
    <name>A0A075MU93_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TRASH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701258.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MU93"/>
    <dbReference type="STRING" id="1459636.NTE_02698"/>
    <dbReference type="GeneID" id="41598387"/>
    <dbReference type="KEGG" id="nev:NTE_02698"/>
    <dbReference type="HOGENOM" id="CLU_185152_1_1_2"/>
    <dbReference type="OrthoDB" id="37898at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="entry name" value="Ribonucleotide Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011017">
        <property type="entry name" value="TRASH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007029">
        <property type="entry name" value="YHS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04945">
        <property type="entry name" value="YHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00746">
        <property type="entry name" value="TRASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRASH" evidence="1">
        <location>
            <begin position="4"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="47" mass="5233" checksum="B57DC0A305435F09" modified="2014-10-29" version="1">MFKDPVCKMMVDERTAKHVSEAGGRKVYLCSAACKSQFDANPSKFGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUM1</accession>
    <name>A0A075MUM1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aspartokinase</fullName>
            <ecNumber evidence="7">2.7.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NTE_00933</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-aspartate + ATP = 4-phospho-L-aspartate + ADP</text>
            <dbReference type="Rhea" id="RHEA:23776"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the aspartokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.4" evidence="7"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUM1"/>
    <dbReference type="STRING" id="1459636.NTE_00933"/>
    <dbReference type="KEGG" id="nev:NTE_00933"/>
    <dbReference type="eggNOG" id="arCOG00861">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009116_6_0_2"/>
    <dbReference type="OrthoDB" id="8904at2157"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00015"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00461"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00462"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009090">
        <property type="term" value="P:homoserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04924">
        <property type="entry name" value="ACT_AK-Arch_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2130.10:FF:000001">
        <property type="entry name" value="Bifunctional aspartokinase/homoserine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2130.10">
        <property type="entry name" value="VC0802-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054352">
        <property type="entry name" value="ACT_Aspartokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005260">
        <property type="entry name" value="Asp_kin_monofn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001341">
        <property type="entry name" value="Asp_kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00656">
        <property type="entry name" value="asp_kin_monofn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00657">
        <property type="entry name" value="asp_kinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004938">
        <property type="entry name" value="PRK06291.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21499">
        <property type="entry name" value="ASPARTATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21499:SF59">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22468">
        <property type="entry name" value="ACT_9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000726">
        <property type="entry name" value="Asp_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="9">
        <location>
            <begin position="326"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIF83009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="470" mass="49957" checksum="0434B4F0EFE2A8D8" modified="2014-10-29" version="1">MIIVMKFGGTAVDSPDKVRHVAQLIKSHKAGNDVVCVVSAVRGMTDGLLSIADSVRRGDRTSIEDFVKKSLKTHTDIVNGAISDKKLREDALASMKKTIGELEDVLGGIVLLGEVTPKSLDYLMSFGERLSTPIVAYALADMGVDSEYLTGKEAGIVTDSNFGEARPLMDTTKLRVSHRLGPVTKRGAVPVITGFIGADQHGNTTTIGRGGSDYTATIVAASIGASEVWLWSDVDGLMTADPKIVKGAQVLKEVSFAEAMEMALFGAKYMHPRALEPVMDTKIPIRIRNTFNVKHPGTVITQNPSRDSQKIVKSVSAIRHTALIDVSGGGMVGAPGTAAKIFDTLAKNRVNIMMISQSPSESSISMVVRKSDLDKATTTLELNLLGKVIKQVNVSDDVAVIAVVGSGMRGIKGVAAKVFGAVAKRKINVIMIAQGSSELNLAFVVNDSDCEGAVNALHDEFGLGKTRVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUN5</accession>
    <name>A0A075MUN5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein uL18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpl18</name>
        <name evidence="8" type="ORF">NTE_02798</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701345.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUN5"/>
    <dbReference type="STRING" id="1459636.NTE_02798"/>
    <dbReference type="GeneID" id="41598486"/>
    <dbReference type="KEGG" id="nev:NTE_02798"/>
    <dbReference type="eggNOG" id="arCOG04088">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056222_2_0_2"/>
    <dbReference type="OrthoDB" id="8644at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00432">
        <property type="entry name" value="Ribosomal_L18_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01337_A">
        <property type="entry name" value="Ribosomal_uL18_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057267">
        <property type="entry name" value="Rbsml_uL18_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005485">
        <property type="entry name" value="Rbsml_uL18_euk_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057268">
        <property type="entry name" value="Ribosomal_L18"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006342">
        <property type="entry name" value="PRK08569.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23410:SF12">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23410">
        <property type="entry name" value="RIBOSOMAL PROTEIN L5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17144">
        <property type="entry name" value="Ribosomal_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="187"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF84838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="242" mass="26593" checksum="98CCE1C338621C6C" modified="2014-10-29" version="1">MTYVRTLKRIRLDKTNYRKRAAVIVGRHSFATVKVTDQNVAAQILKPTPTGDLVIASAHSHELVTKHGWKGSTNSLPACYLTGLLLGKKALEKGTNKAVLYIGKDHFTTRVATCAKGIADSGVNIPISEESLPDAERISGQHIADYASSLKANEEEYKSRFSALLKNGLKPEDYPAHFEEVRFKISGKAAEEAPKPKKEKKEQAAPAKEGKSSKDNKKASPKKQEAKEEKPKKSEKAGKKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUT0</accession>
    <name>A0A075MUT0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00984</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUT0"/>
    <dbReference type="STRING" id="1459636.NTE_00984"/>
    <dbReference type="KEGG" id="nev:NTE_00984"/>
    <dbReference type="HOGENOM" id="CLU_3379840_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="33" mass="3906" checksum="980D873AE3CA5CAE" modified="2014-10-29" version="1">MFSINKEIMREMQKIAIHDNIEVELAKLKSECI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUU3</accession>
    <name>A0A075MUU3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03403</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701844.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUU3"/>
    <dbReference type="STRING" id="1459636.NTE_03403"/>
    <dbReference type="GeneID" id="41599049"/>
    <dbReference type="KEGG" id="nev:NTE_03403"/>
    <dbReference type="HOGENOM" id="CLU_2055956_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="119" mass="12712" checksum="4322D4CBD66F2BB9" modified="2014-10-29" version="1">MRVVTESTKFLTVLIPAGQTGVFQPTTPLALKSVVRIRQVGISAPTHDATTIITVRAGQHNLIDQYPDLQSFETAPHSGPESAPEIGQSDEITASVKVANAYLANTTVVIAVSYWVVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUV7</accession>
    <name>A0A075MUV7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nitrososphaera output domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUV7"/>
    <dbReference type="KEGG" id="nev:NTE_03418"/>
    <dbReference type="HOGENOM" id="CLU_160434_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041226">
        <property type="entry name" value="NitrOD2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18550">
        <property type="entry name" value="NitrOD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitrososphaera output" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="107" mass="12380" checksum="769F8C5CC14D00A5" modified="2014-10-29" version="1">MAEEILHRLEEIFSRQIFNAICEKITEDFFGNEMDLRTAIVARPDLFERAFHSIFGNTGFRILEPVYDELHKEFGLDKDLTYLGRGDFAKFMGMKSVNSNTPRLASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUW5</accession>
    <name>A0A075MUW5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Exonuclease of the beta-lactamase fold involved in RNA processing</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_02920</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701442.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUW5"/>
    <dbReference type="STRING" id="1459636.NTE_02920"/>
    <dbReference type="GeneID" id="41598598"/>
    <dbReference type="KEGG" id="nev:NTE_02920"/>
    <dbReference type="eggNOG" id="arCOG00545">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050517_0_0_2"/>
    <dbReference type="OrthoDB" id="40950at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240">
        <property type="entry name" value="DNA CROSS-LINK REPAIR PROTEIN PSO2/SNM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240:SF8">
        <property type="entry name" value="PROTEIN ARTEMIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="320"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF84958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="345" mass="38273" checksum="569C6D198D74F4E1" modified="2014-10-29" version="1">MPSSIFHGKSGITVRQKDGTTIALDPSRASDCDYAFVSHAHIDHMHRKGKKSKSRLIVSKETSLLAGARGYSIEGEEEHDGFTLVDTGHILGSRGLLINDKDVYYTGDLSIRERAFMKPAKMPHASTLIIESTFGRPGYKFPAVEEVTHRTNKVISEMYDMGIPVILMGYALGKAQLLTKLFGHWDPVYVHDSVAKMNSVYLDLGVDLKNAISHTEAEERGLLSKSKPWIMVAPLMSGRSAFVQEMKRKYGAVTVGFSGWALDAGYRYRMGLDYAFPMSDHCDYSELVQAVKACAPDKVYTFHGFAEEFATSLKKMGFDAEPVENNDDDEKKSKRGATVSLDSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUZ3</accession>
    <name>A0A075MUZ3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701514.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUZ3"/>
    <dbReference type="GeneID" id="41598680"/>
    <dbReference type="KEGG" id="nev:NTE_03010"/>
    <dbReference type="HOGENOM" id="CLU_2230260_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="105" mass="11389" checksum="A9AA99EA866B7948" modified="2014-10-29" version="1">MLAKARGKRLYRIILILGAIIFIIGFGLHLVKVELTPQETEQLRHMLTCPSGPCTGPFYKAPYAEVGDYMMYAGIAIMIVDGVLLSIRIVTLSGKTSSTTTVAGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MV26</accession>
    <name>A0A075MV26_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Archaeal DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02978</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701486.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MV26"/>
    <dbReference type="GeneID" id="41598649"/>
    <dbReference type="KEGG" id="nev:NTE_02978"/>
    <dbReference type="eggNOG" id="arCOG01753">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1567060_0_0_2"/>
    <dbReference type="OrthoDB" id="12138at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.20">
        <property type="entry name" value="Alba-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036882">
        <property type="entry name" value="Alba-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82704">
        <property type="entry name" value="AlbA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="170" mass="18242" checksum="3E0BFFAEAE15EDE8" modified="2014-10-29" version="1">MMTSVVQESTTTTSLPTTATITTQTRSADNTIPPHVLIVGKKNALDYIAPALFRIGTFGELVVRAKGSMSIVTAVNVAEMVKKDVAELETRSVSIGTEEIVIEGMPKRVSYIEIHLAKPLPKAVVVEAPLPQDKLAETASTAKKIRAKAKKSTTTKKRATATVRKKKADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MV59</accession>
    <name>A0A075MV59_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03508</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701918.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MV59"/>
    <dbReference type="STRING" id="1459636.NTE_03508"/>
    <dbReference type="GeneID" id="41599130"/>
    <dbReference type="KEGG" id="nev:NTE_03508"/>
    <dbReference type="eggNOG" id="arCOG08805">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100103_1_0_2"/>
    <dbReference type="OrthoDB" id="6105at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="Ribbon-helix-helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="186" mass="21856" checksum="2C3019E2C4F9C8F9" modified="2014-10-29" version="1">MQWDNDSKDSDVKKAKTETITFRLPTVLIDELRMDADLEGVTLNSYVARIFVNHVQWERYERKVGLLPMTEAFLGEALIRLSDEQIVNLAQKIEKQRFKRILAFMNDSPNIDDFVEIMRTWLTVSWIQQNIEFRDGKYYFKIQHNLGSKWSLYVKTLISELSQDVLGKQTDIRMMDGDTICFTFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVE0</accession>
    <name>A0A075MVE0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01146</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVE0"/>
    <dbReference type="STRING" id="1459636.NTE_01146"/>
    <dbReference type="KEGG" id="nev:NTE_01146"/>
    <dbReference type="HOGENOM" id="CLU_3056948_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="53" mass="6054" checksum="81BD4F5EFC8CA0ED" modified="2014-10-29" version="1">MDFFNKSDLLHKAVVNRKILNSFTSWDFQLKVSSNNPSAIRYNSAPGKKPMPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVG6</accession>
    <name>A0A075MVG6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVG6"/>
    <dbReference type="STRING" id="1459636.NTE_01181"/>
    <dbReference type="KEGG" id="nev:NTE_01181"/>
    <dbReference type="HOGENOM" id="CLU_2534503_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="83" mass="9145" checksum="8035A11C898FFA6C" modified="2014-10-29" version="1">MAVIIIVKTILALLAIGVASFTLTPVMYSLKENPSLWTHCSSQCLQIRDNLYNIYFYIPVALVGVVVLFAIMSASRRAPDEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVK5</accession>
    <name>A0A075MVK5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03236</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVK5"/>
    <dbReference type="STRING" id="1459636.NTE_03236"/>
    <dbReference type="KEGG" id="nev:NTE_03236"/>
    <dbReference type="HOGENOM" id="CLU_2519587_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="84" mass="9699" checksum="6D06FA2BE589E443" modified="2014-10-29" version="1">MYACVRWCMSSKHPIQQDKADEVKALIARYVLLKIEQKKIEAKLGEITQFYDEESLRRIFEPIGDSMMGIIGLELPRKKDANIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVM9</accession>
    <name>A0A075MVM9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative nucleoside-diphosphate sugar epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700139.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVM9"/>
    <dbReference type="GeneID" id="41597088"/>
    <dbReference type="KEGG" id="nev:NTE_01285"/>
    <dbReference type="eggNOG" id="arCOG03015">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_10_5_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051604">
        <property type="entry name" value="Ergot_Alk_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43162">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43162:SF1">
        <property type="entry name" value="PRESTALK A DIFFERENTIATION PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="1">
        <location>
            <begin position="11"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="306" mass="33108" checksum="BB4920DDD7C861C8" modified="2014-10-29" version="1">MANNKDNGTTYAVVGASGNTGRIVAEQLLASGKNVRAISRNADHLKALVDKGAEPFIASIEDKPALTKAFTGARAVYSMIPPNMAAVDRTSYIDKVGEALAGAIAEAHVPYVVNLSSMAANKDEQGFQGRMYEQEQRLNRLPDAINVVHLRPPMFMENFLASINAIKKAGVIAYPIKPDIAIPMIATQDIASEAARLLLDLNFSGKSAKTLLGQRDVSMAEAAKIIGRAINKDVRYVQVPYDEHIKTLVQAGIPLDVARTLTGLYRRMNEGTGIPLEKRTSENTTPTSFEQFAQKFAAIYNNGSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVT1</accession>
    <name>A0A075MVT1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein translation factor SUI1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NTE_03331</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the SUI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVT1"/>
    <dbReference type="STRING" id="1459636.NTE_03331"/>
    <dbReference type="KEGG" id="nev:NTE_03331"/>
    <dbReference type="eggNOG" id="arCOG04223">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082805_6_1_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002188">
        <property type="term" value="P:translation reinitiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11567">
        <property type="entry name" value="YciH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050318">
        <property type="entry name" value="DENR/SUI1_TIF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005872">
        <property type="entry name" value="SUI1_arc_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12789:SF0">
        <property type="entry name" value="DENSITY-REGULATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12789">
        <property type="entry name" value="DENSITY-REGULATED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037511">
        <property type="entry name" value="Transl_init_SUI1_pro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="SUI1" evidence="5">
        <location>
            <begin position="15"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR037511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF85360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="89" mass="10097" checksum="1CCA1B66E7F41923" modified="2014-10-29" version="1">MDELVKELDKERTRIIISKDIRKWNKPTTVISGLHDRKDAPEITKKLKTKIGTGGTFKDGQIILQGDHRDTVKNMLVSMGFGEDSIEVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVT4</accession>
    <name>A0A075MVT4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Prokaryotic metallothionein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVT4"/>
    <dbReference type="STRING" id="1459636.NTE_02690"/>
    <dbReference type="KEGG" id="nev:NTE_02690"/>
    <dbReference type="HOGENOM" id="CLU_2874906_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="63" mass="7054" checksum="242B2333B6588260" modified="2014-10-29" version="1">MLGLLQKHCPVCGMDVDKNTAMKRFGKYFCSEEHAGQYAEMKMARDIERKDYEDRGSGGGGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MW25</accession>
    <name>A0A075MW25_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nicotinamide-nucleotide adenylyltransferase</fullName>
            <ecNumber evidence="4">2.7.7.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">NAD(+) diphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">NAD(+) pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">NMN adenylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NTE_03324</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>beta-nicotinamide D-ribonucleotide + ATP + H(+) = diphosphate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:21360"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="EC" id="2.7.7.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from nicotinamide D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the archaeal NMN adenylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.1" evidence="4"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701772.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MW25"/>
    <dbReference type="STRING" id="1459636.NTE_03324"/>
    <dbReference type="GeneID" id="41598975"/>
    <dbReference type="KEGG" id="nev:NTE_03324"/>
    <dbReference type="eggNOG" id="arCOG00972">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108783_0_0_2"/>
    <dbReference type="OrthoDB" id="264480at2157"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000309">
        <property type="term" value="F:nicotinamide-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00243">
        <property type="entry name" value="NMN_adenylyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006418">
        <property type="entry name" value="NMN_Atrans_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002243">
        <property type="entry name" value="PRK01153.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21342:SF0">
        <property type="entry name" value="BIFUNCTIONAL NMN ADENYLYLTRANSFERASE_NUDIX HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21342">
        <property type="entry name" value="PHOSPHOPANTETHEINE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 4 6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="5">
        <location>
            <begin position="9"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF85353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="184" mass="20726" checksum="5B868ADBC54BF7D4" modified="2014-10-29" version="1">MSKFKRGLMTGRFQPFHNGHLALAKQALEECDELAIVIGSAQFNFIEKDPFTAGERVLMIHAALDEAGIDLSRCYIIPVANDENNARWLAYLRSQVPPFDALYSGNDFVDHLARSQDPSLAVRKPEFAKRQEYNGTNIRSLIVTGKEERWEHLVPPAVAKVIKDVGGVERMKMLSRSDSNPAKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MW41</accession>
    <name>A0A075MW41_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03442</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701874.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MW41"/>
    <dbReference type="STRING" id="1459636.NTE_03442"/>
    <dbReference type="GeneID" id="41599080"/>
    <dbReference type="KEGG" id="nev:NTE_03442"/>
    <dbReference type="eggNOG" id="arCOG00723">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077467_0_1_2"/>
    <dbReference type="OrthoDB" id="15220at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007438">
        <property type="entry name" value="DUF488"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014519">
        <property type="entry name" value="UCP024492"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39337">
        <property type="entry name" value="BLR5642 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39337:SF1">
        <property type="entry name" value="BLR5642 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04343">
        <property type="entry name" value="DUF488"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF024492">
        <property type="entry name" value="UCP024492"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="178" mass="20233" checksum="8F6F6DEDC66F71E0" modified="2014-10-29" version="1">MKTGAIVYTIGHSTRTINEFVKILRAYKIQTVVDVRTIPKSRHNPQFNEEELRANLLKNDIGYIHMEGLGGLRHTTKASVNTAWRNSSFRGFADYMQTSEFKNSIELLIKISAKKQAVIMCAEAVPWRCHRSLIGDALVIRNIRVEDIMSENTSKPHTLTWFAKVGGNEITYPEVDDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWH8</accession>
    <name>A0A075MWH8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Kef-type K+ transport system, predicted NAD-binding component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NTE_03455</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWH8"/>
    <dbReference type="STRING" id="1459636.NTE_03455"/>
    <dbReference type="KEGG" id="nev:NTE_03455"/>
    <dbReference type="eggNOG" id="arCOG01955">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005126_1_2_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42751">
        <property type="entry name" value="SODIUM/HYDROGEN EXCHANGER FAMILY/TRKA DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42751:SF3">
        <property type="entry name" value="SODIUM_GLUTAMATE SYMPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="283"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="8">
        <location>
            <begin position="25"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF85483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="414" mass="42998" checksum="E0932EABD31745D2" modified="2014-10-29" version="1">MIEITQDMAEIAAAQVIQDFAIIMVVASVMALVSYKLKQPMVIGYIAAGMIIGPHTPPFSLILHPEILNLLAEIGIVLLLFVVGLEYPIAKLRAVGKKALVIAFAEAFGTFGIGIAVGQAMGMTLFDSMFIALAISVTSTVVLSQVMREFGIAKTDTASLILGVTVIEDIIIVSTLAVLQSVASTGNLTIVEIGTSVGLVLAFIGGALFIGSKTVPKFVDMVGKTNHFDVLLVAILGVAFGLAFIANELGISVAAGAFFAGVLVAESKGHATAHVLTTPLKDMFAALFFVSIGALMDISQLPLFIVPALIFIAVSFASKFATVYLSAKSQGLDKKTALQAAFGSSASGGELALVTAKGGADVGATSGFVLPMVGAMTIITSFLSPYVVKFGFKIGERIAPSSEVKKDDKEGKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWK0</accession>
    <name>A0A075MWK0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_01586</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700381.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWK0"/>
    <dbReference type="STRING" id="1459636.NTE_01586"/>
    <dbReference type="GeneID" id="41597366"/>
    <dbReference type="KEGG" id="nev:NTE_01586"/>
    <dbReference type="HOGENOM" id="CLU_2447521_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF83649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="89" mass="9555" checksum="9E1574DEBEE29F64" modified="2014-10-29" version="1">MLALIVKNKRIVQGTGMSFLVIGTTMHAFNVANLMTPTLSHTWSAVAISGFVLTASSQIGGNLVKKVRHIRKSKPGSRSSNNHDDVVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MXV5</accession>
    <name>A0A075MXV5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03424</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385673.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MXV5"/>
    <dbReference type="GeneID" id="43502683"/>
    <dbReference type="KEGG" id="nev:NTE_03424"/>
    <dbReference type="HOGENOM" id="CLU_3075141_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="52" mass="6271" checksum="3CE0A9409514A4C5" modified="2014-10-29" version="1">MSLPLLHFLPYSTGPRFFNSNLQFVKKWFDVDYIDYGITWRRRQKCATERAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MXW4</accession>
    <name>A0A075MXW4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MXW4"/>
    <dbReference type="STRING" id="1459636.NTE_02073"/>
    <dbReference type="KEGG" id="nev:NTE_02073"/>
    <dbReference type="eggNOG" id="arCOG01055">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_159725_1_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038723">
        <property type="entry name" value="ArnR1-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14947">
        <property type="entry name" value="HTH_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ArnR1-like winged helix-turn-helix" evidence="1">
        <location>
            <begin position="8"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="106" mass="12126" checksum="539016C7B3670412" modified="2014-10-29" version="1">MIVLPKPKRNKMEIYNDILSAIAQELTNGEAKPTRVQTLSNLAYDKLARYLDELESKKMIIQDPLGITEKGRDFLQDYDRIKDFVIAMGVKYLDVPSGGEMGVYER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MXY8</accession>
    <name>A0A075MXY8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Putative asparagine synthetase [glutamine-hydrolyzing]</fullName>
            <ecNumber evidence="8">6.3.5.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">NTE_03474</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>L-aspartate + L-glutamine + ATP + H2O = L-asparagine + L-glutamate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12228"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.4" evidence="8"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701894.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MXY8"/>
    <dbReference type="STRING" id="1459636.NTE_03474"/>
    <dbReference type="GeneID" id="41599104"/>
    <dbReference type="KEGG" id="nev:NTE_03474"/>
    <dbReference type="eggNOG" id="arCOG00071">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG00093">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014658_4_0_2"/>
    <dbReference type="OrthoDB" id="8692at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00352">
        <property type="entry name" value="Gn_AT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006426">
        <property type="entry name" value="Asn_synth_AEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050795">
        <property type="entry name" value="Asn_Synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01536">
        <property type="entry name" value="asn_synth_AEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11772">
        <property type="entry name" value="ASPARAGINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11772:SF2">
        <property type="entry name" value="ASPARAGINE SYNTHETASE [GLUTAMINE-HYDROLYZING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13522">
        <property type="entry name" value="GATase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001589">
        <property type="entry name" value="Asn_synthetase_glu-h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 9" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="4 8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="1 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 8 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="12">
        <location>
            <begin position="2"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="9">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="447"/>
            <end position="448"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR001589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIF85502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="665" mass="74593" checksum="723639BBFA0B6A48" modified="2014-10-29" version="1">MCGIAGVLGKSENKKQKKTNVVPLVKSMLSCMVHRGPDGAGIAADDEVIINTNSIASLAAYKIRASSSVVGHNRLAIVGGTTCGSQPFVSCDKRLVLEHNGEIYNYKLLRKKLENCHNFKTLTDSEVIVHLLEDNLKTIEEQSEEKERERREKKTSEKEENSKAKILELEATASEEAGAILLKAIQKTIAELDGVYALVIRDTKTGYTALVRDRLGVRQLYYAQTDKFLAFASELKALWKIGINEQIERVMPCTAVMISPGCEKIETHAVASIMSDIVLVAADDNRRWKERRKKKKVGGGRRSNDNNNNYWKPRYYRTMRKSLREYRLALLKSMQKRTQDFERIGIIFSGGIDSVMIAHLAKQMVPNIICYTGGIKGSSDIEYARQIAKELDLDLRVNEMTRQDIEELVPEIITVIEDNNAGQVEVALPVYAAVELAHKDGIRVMLSGQAADELFGGYPWYAKVVEREGYDKLREHMTEDLFLLYKETLEREDKITMAHSVELRVPFLDPEVVNVAMRINPCFNVKGGDDIFGKHVHRELAVAMGIPRNIAYRVKEAAQHGSGTHGALDAIARRSGFASSDVPDSYLEELRGRERIGSSQRYGYLFGNKRSWVAEPHVQMYLDKMARTVLPNFDTLVRSSVSSSSMTPLALVKEKAGSRNSAKFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MZU2</accession>
    <name>A0A075MZU2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_02712</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385539.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MZU2"/>
    <dbReference type="STRING" id="1459636.NTE_02712"/>
    <dbReference type="GeneID" id="41598402"/>
    <dbReference type="KEGG" id="nev:NTE_02712"/>
    <dbReference type="eggNOG" id="arCOG01057">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111585_5_3_2"/>
    <dbReference type="OrthoDB" id="10490at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33204">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR, MARR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33204:SF18">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="4">
        <location>
            <begin position="22"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF84754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="137" mass="15907" checksum="02768C75AD12C39D" modified="2014-10-29" version="1">MSDKECSMIMEAVYDMPELKSCPIETTFKIIGKRWTVLIIRELLRGTTQFNRFLENIEGITPKVLTERLRELQRFGIVRRQIVSDSPIRVEYGLTDLGKEFEPVLLAAASFSMRHMPTTVFKDGKPRTPDDILMRQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N0K7</accession>
    <name>A0A075N0K7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">methionine synthase</fullName>
            <ecNumber evidence="5">2.1.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">5-methyltetrahydrofolate--homocysteine methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">NTE_02979</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">SR1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>methylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:28115"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetH route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the vitamin-B12 dependent methionine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.13" evidence="5"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987025.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N0K7"/>
    <dbReference type="STRING" id="1459636.NTE_02979"/>
    <dbReference type="GeneID" id="41598650"/>
    <dbReference type="KEGG" id="nev:NTE_02979"/>
    <dbReference type="eggNOG" id="arCOG08715">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004914_3_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008705">
        <property type="term" value="F:methionine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050667">
        <property type="term" value="P:homocysteine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046653">
        <property type="term" value="P:tetrahydrofolate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.330:FF:000001">
        <property type="entry name" value="Methionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.330">
        <property type="entry name" value="Homocysteine-binding-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017226">
        <property type="entry name" value="BHMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003726">
        <property type="entry name" value="HCY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036589">
        <property type="entry name" value="HCY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050554">
        <property type="entry name" value="Met_Synthase/Corrinoid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45833">
        <property type="entry name" value="METHIONINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45833:SF1">
        <property type="entry name" value="METHIONINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02574">
        <property type="entry name" value="S-methyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037505">
        <property type="entry name" value="Betaine_HMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82282">
        <property type="entry name" value="Homocysteine S-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50970">
        <property type="entry name" value="HCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="14" id="KW-0170">Cobalt</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="6 17" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="9 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Hcy-binding" evidence="16">
        <location>
            <begin position="7"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AIF85014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="320" mass="35114" checksum="DD02CBE8FC1228FB" modified="2014-10-29" version="1">MSPSQAREPFLEAAKKRRLLFDGAMGTEIQKLSPRPEDFPNGKDGFNDGLVLTRPEWIKNIHRSYLKAGADCIETNTFGSNKFKLEEYGYGDQTVKFNKKAAQLAREVADEFEGRYVIGSMGPTGFLPSSNDPDLGQKPLDEIREAFALQAEGLILGGVDALLIETSQDILEVKLAIEASHQAMEKVGKKVPIIANVTLDQYGKMLLGTSVQAAYTTVSDMGIDFFGLNCSTGPAEMEPSVKWLAEQDLPILVMPNAGMPHNEGGKAVYKMKPKDVAHKMEDFVKSYENVRLIGGCCGTNPKHIAELRRVLEMTPPSSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N1L4</accession>
    <name>A0A075N1L4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N1L4"/>
    <dbReference type="STRING" id="1459636.NTE_03325"/>
    <dbReference type="KEGG" id="nev:NTE_03325"/>
    <dbReference type="HOGENOM" id="CLU_3210881_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="47" mass="5082" checksum="26FB0668A0C00A85" modified="2014-10-29" version="1">MHEMGKGLRACPICPGCGSKKFRIIERDDSAGKVTVECASCARRITV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N1Q3</accession>
    <name>A0A075N1Q3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03361</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N1Q3"/>
    <dbReference type="STRING" id="1459636.NTE_03361"/>
    <dbReference type="KEGG" id="nev:NTE_03361"/>
    <dbReference type="HOGENOM" id="CLU_3263612_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="41" mass="4754" checksum="1B4176AE2BDA38E0" modified="2014-10-29" version="1">MYVYEIARNRSQYHKMLFVTMHIASGTSEGQLSYFPTADLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N1Z6</accession>
    <name>A0A075N1Z6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03446</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N1Z6"/>
    <dbReference type="KEGG" id="nev:NTE_03446"/>
    <dbReference type="HOGENOM" id="CLU_3194333_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="45" mass="5157" checksum="C2BAC7A339B32A90" modified="2014-10-29" version="1">MFVEISKKRSGYGSEGCWKINAEEIATNECSIKLEKSYERALLML</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N230</accession>
    <name>A0A075N230_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03476</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N230"/>
    <dbReference type="KEGG" id="nev:NTE_03476"/>
    <dbReference type="HOGENOM" id="CLU_3056954_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="53" mass="6005" checksum="BE270E1740F7A74D" modified="2014-10-29" version="1">MYMSQEREGKRAPPVKEIDSNTPVEEAPRTNTGVKIDDPEEIEAADEEEDKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLG7</accession>
    <name>A0A075MLG7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00029</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLG7"/>
    <dbReference type="KEGG" id="nev:NTE_00029"/>
    <dbReference type="HOGENOM" id="CLU_1163761_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="238" mass="26216" checksum="AD7933BB6035B91C" modified="2014-10-29" version="1">MAVFLLVVLLVASLFACMTPLVIAWAADSGYPYMMEGRGKITTEFEGHKESSIVNATDYYYIYTEFSNPAEQPKDLVRVFYVVNVIDSYGYPQYVDANNYGNRTVAGHASSGYALLWNPLVPGNYTIKTFLVSSYDAPQALSSVATFHVNVDEKVDTLGEGESNNRLRVESINKADNSVTIAYDYCDEIIPYMHSTKAALHSGEHVSINSVDAYLADIRGGNATFRFVSNGGSDFCLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLH5</accession>
    <name>A0A075MLH5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00229</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLH5"/>
    <dbReference type="KEGG" id="nev:NTE_00229"/>
    <dbReference type="HOGENOM" id="CLU_2765842_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="69" mass="7995" checksum="FB8275D44BEF09E7" modified="2014-10-29" version="1">MCVCMYVCVLNKCVLKTFAFSLIKPQLPAIFVLRAEALVAVNICQFDRARFIKCKTFKVVPRVLFHRDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLL2</accession>
    <name>A0A075MLL2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA polymerase II large subunit</fullName>
            <shortName evidence="14">Pol II</shortName>
            <ecNumber evidence="14">2.7.7.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Exodeoxyribonuclease large subunit</fullName>
            <ecNumber evidence="14">3.1.11.1</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">polC</name>
        <name evidence="18" type="ORF">NTE_00079</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 14">Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2 14">Heterodimer of a large subunit and a small subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 14">Belongs to the archaeal DNA polymerase II family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="14"/>
    <dbReference type="EC" id="3.1.11.1" evidence="14"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699217.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLL2"/>
    <dbReference type="STRING" id="1459636.NTE_00079"/>
    <dbReference type="GeneID" id="41596027"/>
    <dbReference type="KEGG" id="nev:NTE_00079"/>
    <dbReference type="eggNOG" id="arCOG04447">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001154_0_0_2"/>
    <dbReference type="OrthoDB" id="7529at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008310">
        <property type="term" value="F:single-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00324">
        <property type="entry name" value="DNApol_II_L_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004475">
        <property type="entry name" value="PolC_DP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056172">
        <property type="entry name" value="PolC_DP2_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056171">
        <property type="entry name" value="PolC_DP2_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016033">
        <property type="entry name" value="PolC_DP2_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00354">
        <property type="entry name" value="polC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003103">
        <property type="entry name" value="PRK04023.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42210">
        <property type="entry name" value="DNA POLYMERASE II LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42210:SF1">
        <property type="entry name" value="DNA POLYMERASE II LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24846">
        <property type="entry name" value="PolC_DP2_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24844">
        <property type="entry name" value="PolC_DP2_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03833">
        <property type="entry name" value="PolC_DP2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016275">
        <property type="entry name" value="PolC_DP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 14" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10 14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 14" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="8 14" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 14" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6 14" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4 14 18" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14 18" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA polymerase II large subunit DP2 N-terminal" evidence="15">
        <location>
            <begin position="21"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase II large subunit DP2 central" evidence="16">
        <location>
            <begin position="302"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase II large subunit DP2 catalytic" evidence="17">
        <location>
            <begin position="712"/>
            <end position="1009"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF24844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF24846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="AIF82163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="1137" mass="125790" checksum="F735118E184C4C69" modified="2014-10-29" version="1">MMLSEGEARLKDIRMPAYYRRYQHDILASVQKYYEHALRARRKGIDVADVVEPKIAFDLADRVAKMHNIEIAERLRALLGQTTKEKAALKIAEEIAKGEYGTGDLRTRLDNAVRVSLAVVTEGVTVAPLQGISDVTIKNNADGSQYLSVSFAGPIRSAGGTEAALTMLIADHARKVAGLGTYKANSFDDETGRFVEELRIYEREVMGFQFKVLDEDVVKCIASLPVELDGVDTDPVDVVGHKGMRRIATDRVRGGALRVMNDGLIGRSRKLLKLVETLKLDGWQWLKELKGAIQTGDDDAAHHRMSEVITGRPVLSMVKKVGGFRLRYGRSPNTGFATVGIHPAVPALLNYAIVAGTQIKMDIPGKASTIALVDTVEPPVVRMDDGRVLAVNSVEQAEKIRPRVQKILYLGDMLISYGDFLENNAQLPPASYVEEIWALQLRSKLAAASIDDDNNNGINRDRLVQLIENPLTITPTVDEAFEVSKKFGVPLHPRYSFYFDVVTVQELLYLKEKLAEDLPNDPELKTILEKLGVSHSISNNNNKIVLDDPSQAKSLAALLSGPMPVGEAKDAIEFVTKSSGITVMQKFASSIAVRVGRPEKAAERKMKPPVHVLFPIGAKGGATRDIIKACGEESLFTQIANRYCETCHLPSLGTHCRSCGASTMLRSQCPICKGEVEEGEKCPRCNRDGRTYASMNFPLKSALQMAEKKLGIRAQEPLKGVKSLMSRDKAAEPLEKGILRQKHELHAFKDGTIRFDATNEPLTHFVPAWIGVSVDKLKELGYTRDYLGRELVSSDQLVELMMQDVIIPRDSAKHLVNAAKFIDEELEKLYEQEPFYNVDAVSDLVGHLVVGLAPHTSVGIMGRIIGFTDSQVCLGSPIWHSAKRRDCDGDADSIMLLMDAFLNFSFDFLPDKIGGLMDAPLLIQPTVLPHEVQRQAHNVDIASSYPLEFYEATWKQAKAADVASMIEIVKSRIGEETQFFGYGFTHPTTGLTTKQQRSAYSTLNTMDEKLKMQFDTAKLISAVDADEVAAMVLTTHILPDIMGNMRSYSSQTFRCTNCGEKFRRMPLVGKCTECGNGLTQTVTRGAVEKYLGIATGFCQEYKINEYLKSRVESISAELKLIFQEEKKVQSSLTEFMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLY2</accession>
    <name>A0A075MLY2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00166</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLY2"/>
    <dbReference type="KEGG" id="nev:NTE_00166"/>
    <dbReference type="HOGENOM" id="CLU_3038858_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="54" mass="5854" checksum="6AD73AF738B383A8" modified="2014-10-29" version="1">MLGAMVVIGSLLVIVLLFAFYIFPTVMCGPDQTSGNRGNADFKDPIVEFCKVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMA6</accession>
    <name>A0A075MMA6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cation diffusion facilitator family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NTE_00173</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699282.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMA6"/>
    <dbReference type="STRING" id="1459636.NTE_00173"/>
    <dbReference type="GeneID" id="41596104"/>
    <dbReference type="KEGG" id="nev:NTE_00173"/>
    <dbReference type="eggNOG" id="arCOG01480">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021126_0_1_2"/>
    <dbReference type="OrthoDB" id="290964at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006829">
        <property type="term" value="P:zinc ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040177">
        <property type="entry name" value="SLC30A9"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13414">
        <property type="entry name" value="HUEL-CATION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13414:SF9">
        <property type="entry name" value="PROTON-COUPLED ZINC ANTIPORTER SLC30A9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="7">
        <location>
            <begin position="10"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF82255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="324" mass="35483" checksum="8B628DB70B64F266" modified="2014-10-29" version="1">MAGGSKKAIYAALFGNLGIAIAKLIAAIFTGSTAMWAETYHSFSDTFNQILLLVGIRTSAKAATERHPFGYGKEQFFWSFLVATMLFGISGVLSLEQGATSLLVAPHHIQNVSVSYIILAISAAFEGNALRVAFVVFKQAIEARGEKVSLRTLYNEFRESKDPSILTVMVEDSAALLGITIAAVGIFLSEATGNTIYDAVSSLAIGVILMVFASFLAKENKALLIGEAISRKEWKRIVDSVLQIREVNRVVSLRTMHFAPQDVLVAMEVNLKDGLDTDKIELVIDKIEKQVKVTIPYINPSKIYVELEQDSCPTDFKRKPEKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMB8</accession>
    <name>A0A075MMB8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00316</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMB8"/>
    <dbReference type="KEGG" id="nev:NTE_00316"/>
    <dbReference type="HOGENOM" id="CLU_156997_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="95" mass="11229" checksum="B41C1EB972228476" modified="2014-10-29" version="1">MQKTVVKYVKGLSETASAFEKRNHKKYGGLNHICRQIEYDVKHGVTEKEVISMLQKVRNHPSYSELRKGNGSMERLKEVEVHFTRPRIEFQQKPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMH0</accession>
    <name>A0A075MMH0_9ARCH</name>
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        <recommendedName>
            <fullName evidence="3">Deazaflavin-dependent oxidoreductase, nitroreductase family</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00585</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMH0"/>
    <dbReference type="KEGG" id="nev:NTE_00585"/>
    <dbReference type="eggNOG" id="arCOG07802">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2379252_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004378">
        <property type="entry name" value="F420H2_quin_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04075">
        <property type="entry name" value="F420H2_quin_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="94" mass="11233" checksum="A62A06BE1428832F" modified="2014-10-29" version="1">MGWKTGKRHQIEIWFVKYDDKYYVMSEHGERSHWVQNIAHDPNVSFRVSDKRFEGTARIVKQRDEPRLAKEVAKLMNAKYRWDDGLIVELKPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMJ4</accession>
    <name>A0A075MMJ4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00605</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699607.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMJ4"/>
    <dbReference type="STRING" id="1459636.NTE_00605"/>
    <dbReference type="GeneID" id="41596468"/>
    <dbReference type="KEGG" id="nev:NTE_00605"/>
    <dbReference type="HOGENOM" id="CLU_1418731_0_0_2"/>
    <dbReference type="OrthoDB" id="6293at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="190" mass="21259" checksum="3265AF976826814A" modified="2014-10-29" version="1">MPIFAVDALVEALAALGYACKEGARSDVMPDRWPYFERWLQNRDGFVTMESGHVDFIGIEEVVRMGPFFNVYCLVGNDSLSGNDDNAHNLLDASPYFQLHNGRPKNLGWSGGVLSNLLAQDAELSAELAKNIMKEECRRINVRAHNYCCVVETSVWDPAGLASVFGIIDRMAMHARKLMKQVHFGESEYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMT4</accession>
    <name>A0A075MMT4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, AsnC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00068</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699210.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMT4"/>
    <dbReference type="STRING" id="1459636.NTE_00068"/>
    <dbReference type="GeneID" id="41596018"/>
    <dbReference type="KEGG" id="nev:NTE_00068"/>
    <dbReference type="eggNOG" id="arCOG01117">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_170329_2_2_2"/>
    <dbReference type="OrthoDB" id="8136at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription regulator AsnC/Lrp ligand binding" evidence="1">
        <location>
            <begin position="18"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="76" mass="8571" checksum="19DC23B79D5E6FD9" modified="2014-10-29" version="1">MTKAFVLISADTGVEGLLHEEIKALDGVKEVYELYGEYDIMAVVEEPTEKEVQRVVSWELRKIKGVRSTNTMVVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMT5</accession>
    <name>A0A075MMT5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00507</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMT5"/>
    <dbReference type="KEGG" id="nev:NTE_00507"/>
    <dbReference type="HOGENOM" id="CLU_2629525_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="77" mass="9115" checksum="CCB95BF6947B7B6D" modified="2014-10-29" version="1">MVLFVKAMHPLDSEHRITKSVIKDWVWTEYNRSLYVGGAGKALQRNVCMYMYVCFRMHVCVRMRVDTISECLENIQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMU8</accession>
    <name>A0A075MMU8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00078</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699216.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMU8"/>
    <dbReference type="STRING" id="1459636.NTE_00078"/>
    <dbReference type="GeneID" id="41596026"/>
    <dbReference type="KEGG" id="nev:NTE_00078"/>
    <dbReference type="eggNOG" id="arCOG08800">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_941989_0_0_2"/>
    <dbReference type="OrthoDB" id="382053at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="295" mass="31091" checksum="8D910F888F015506" modified="2014-10-29" version="1">MANNHRSDLHWAGILAVIASMLLVGSPALIALANAEEANSSHSPGKVVVASSPVYLADKNDKHGGGSSGGSGSGSSSDSGDTTTTNNGDNNSSSSGSGSSDSSSNEGDNSGSGTTDNQEENEETSASGANDESGNDDSQAILVAQEAQQQDDEQPETPLKEEEKSYPEDTYPDSYFSDRPLKKMELQRYLILDEDGNAVSDAKPGDSIKIVASYKNLQQKEQRYALITQIVDQDGVTLDVSWSMDMVESGGYIDWFKLWKPSGPAVCTIKTVVWSGVGENPVPLSETSVTAVVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MN43</accession>
    <name>A0A075MN43_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699812.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MN43"/>
    <dbReference type="STRING" id="1459636.NTE_00870"/>
    <dbReference type="GeneID" id="41596712"/>
    <dbReference type="KEGG" id="nev:NTE_00870"/>
    <dbReference type="HOGENOM" id="CLU_357771_0_0_2"/>
    <dbReference type="OrthoDB" id="373133at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="754" mass="83200" checksum="3223DBC0491CAC53" modified="2014-10-29" version="1">MAASRIPATNNNSDKTLELRFLGSTEKDQAPRVALFAVEKGVVRKLGSIQGNKIQLSELARNVKEGASYGFGPDIDEKEVTREMLVTFRPREKVAEWSRTGVIEVTPKWRDWILPIVCVHGDVHRCRPRPWLLADIALAKTTTFTDVLTLRPEISKATTITPSLTLPTICAPICNAVVEVYEKTCCCRLRPPFDIDDILDRLKDLIERVPPIPDPDPGPISPWPELGPIPIPGPGPDPVPIRQMEKAASLVRATGAKVPLGNPPEKLAEDYYMLMSLPLQDRLAYIDAHYYLYPIFCTCSSRKVGETPVNEDGEFSFCYWRPFVRAGCRITYYYKVRQWQDNQWVYIYDGSTTHDYFTASDDAHLRTWKGRACDPGSDVPDPGTNFVMLENIGYIPSWKLASPAQDSELGVSSANPGDGLVNNNYTGQPWGQTLSFRLKFHEGMKGIGAKYYRVSVVRANSSGDPDGVPQVLTDPVAWSRWKWVGTQLQTEAVALGPNAVGSNSGLYLIPYESDAPDGGWLWFQFHQSWNTTMHDNGKHLVIVEVFDGAGNRIKPAGAAGAGIDKPFTFRRWSTETATDAVNYAALVHMFHADNVACYGDIVALRKNDAPVEGSCLFLTGCSGDKFTVRFYAFHVNKFMHSYNLWFVRGLNDTSGTIETGTANAPSTVPPIPSPLNAANAKAAEKTFGEMLGAHQKCSFAIELRVYPKHTNGFGIITGYGASDTAAVALEQVPCVDLGSIPRIAAATEKRELPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MN48</accession>
    <name>A0A075MN48_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699816.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MN48"/>
    <dbReference type="STRING" id="1459636.NTE_00875"/>
    <dbReference type="GeneID" id="41596716"/>
    <dbReference type="KEGG" id="nev:NTE_00875"/>
    <dbReference type="HOGENOM" id="CLU_2021395_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="122" mass="13730" checksum="9C3380D28ED98BD6" modified="2014-10-29" version="1">MPRKEEELLNARLLEGLLKLSEREHAKLDIDILTVIANKPVNYTGMKKYTLYELQAIAGNYARIRRVDIKESDISNSIRRIQALFAASRIDIITLEGLQLAPSKGAAREANSMKSWKTSCVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNA9</accession>
    <name>A0A075MNA9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">KH domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_00633</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699629.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNA9"/>
    <dbReference type="STRING" id="1459636.NTE_00633"/>
    <dbReference type="GeneID" id="41596496"/>
    <dbReference type="KEGG" id="nev:NTE_00633"/>
    <dbReference type="eggNOG" id="arCOG04150">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064992_3_0_2"/>
    <dbReference type="OrthoDB" id="7870at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22390">
        <property type="entry name" value="KH-I_Dim2p_like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000076">
        <property type="entry name" value="KH domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019964">
        <property type="entry name" value="KH_domain_protein_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055211">
        <property type="entry name" value="KH_PNO1_2nd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03665">
        <property type="entry name" value="arCOG04150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826">
        <property type="entry name" value="RIBONUCLEASE Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826:SF13">
        <property type="entry name" value="RNA-BINDING PROTEIN PNO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22891">
        <property type="entry name" value="KH_PNO1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="87"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="187"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="187"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF82713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="214" mass="24400" checksum="1C14098EB173F3C4" modified="2014-10-29" version="1">MSFQHNIKLPRERIAVLIGKGGRIKQEIEKRCGVAIEVDSESGDAVITTGENKPVEQIEMFKAVEIISAISRGFSPQRAMRLLEEEEMLFQQIDLRDYTGRSPNALERVKGRIIGEGGKSRRTIEELSGASVSVYGHTVSLIGTYHEVRLATDAIDMLCRGSMHKSVYNMLQEARRRDKMDRMRLWEDDKHDVEGREEGKEDEEEGITEEEKTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNR2</accession>
    <name>A0A075MNR2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF2283 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699673.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNR2"/>
    <dbReference type="GeneID" id="41596546"/>
    <dbReference type="KEGG" id="nev:NTE_00690"/>
    <dbReference type="HOGENOM" id="CLU_2730597_0_0_2"/>
    <dbReference type="OrthoDB" id="371681at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019270">
        <property type="entry name" value="DUF2283"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10049">
        <property type="entry name" value="DUF2283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="75" mass="8397" checksum="6441D17B99E05342" modified="2014-10-29" version="1">MALVTFDPDAKTMYVSLEKKKVRIAKTIPMGEGKYLDVTENNEPVGLEIILPRNVSEEVVDAIVNRGKSKIEVKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNS6</accession>
    <name>A0A075MNS6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Spermidine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01123</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700006.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNS6"/>
    <dbReference type="STRING" id="1459636.NTE_01123"/>
    <dbReference type="GeneID" id="41596937"/>
    <dbReference type="KEGG" id="nev:NTE_01123"/>
    <dbReference type="eggNOG" id="arCOG00050">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018383_0_0_2"/>
    <dbReference type="OrthoDB" id="10538at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004766">
        <property type="term" value="F:spermidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001045">
        <property type="entry name" value="Spermi_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11558:SF11">
        <property type="entry name" value="SPERMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11558">
        <property type="entry name" value="SPERMIDINE/SPERMINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01564">
        <property type="entry name" value="Spermine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="622"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="663"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="696"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="728"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="763"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="809"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="838"/>
            <end position="858"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="874" mass="95221" checksum="90B483C60B7A1358" modified="2014-10-29" version="1">MLDYSLKTNRNMLAFLMAVLFFASLSTVLFELALTRVFSIILWYDYAFMAISVAFFGLGIGSLLVHMQKDYGNGTQHRGGIWRWLSTPQTMMTPAALAKKITEHSIAYAISVPLFILAIALIPPDTSYIYVFYLISSIPFFFAGSIMALVFFAMPRQISKLYFADLVGASSAALMLDPLMLGLGAESVLLLTSLLVAGSAIIGALLLLRNGNSRQKAAGPPEAMVMTKRSKITAAVVLAGIAILLVVSSPAAMAAMQPQVAKGIDTFAKVHPGPNKGLYWQLKNPAFEHLSAMWNSFSRVDVTTQHSLEGVDVGAGTPVRSSHELAHIIIDADAGTPIYGWSGDRADLAWMRDYMDYVPYNLTRAGHVLVIGGGGGEDIMMALAGGADKVTAVEINPLIVSAVKRFGGPANVYDNPNVDLFIDDGRRFISSTIDKYDVITIKLVDSWAAQLAGGYALSENYLYTVEAFQQYYRHLSNDDGMLVMIRWNFELPRLMPIVAESVARETGQSMEDASKQIMVVEDRPGLYFGRTQDSQQYYPVLVMVKASPFTDEQVNLVKQKAEAGRADVTMLADSMINPPYDKLFSSASTYGDYVAASSLGNPKVPTDDSPFYFAKEPVPQQMVILLETVLVISAALSVILVYHARKTGTKFRQRGEPGMTARTAGFVMFAVFIGLGFMILEITFIQKFLLLLGTPIMALTVILFSILLSSGIGAYVSGRMFRDRPHRAVFVSVPILVSIILSYFFFLQGIIDSSITMELSSRAALTFALLFPSGLLMGFQFPALIRMASTPLRFANGARENKNNNNTTLLWGINVIASILGTVLAAMLAMIIGFNGNLLVGLAMYAGAGASALLSFVAGKRYYANQAPPLTERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MP44</accession>
    <name>A0A075MP44_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00859</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_075055571.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MP44"/>
    <dbReference type="GeneID" id="41596702"/>
    <dbReference type="KEGG" id="nev:NTE_00859"/>
    <dbReference type="eggNOG" id="arCOG04362">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1922676_0_0_2"/>
    <dbReference type="OrthoDB" id="6902at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="131" mass="14836" checksum="ECA85F250D79F26A" modified="2014-10-29" version="1">MAKSQTTATVLRTISDDRSMELFRTIAHGSIDSESLKGKTKLTRKQYYSRLSRMTKSGLVRKKSGKYTLTAFGKVVYDSQMTVDNALTNFWKLKAIDSLEMSNELPKEEQQKLIDTLLDNQELKGILVKGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPF5</accession>
    <name>A0A075MPF5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPF5"/>
    <dbReference type="STRING" id="1459636.NTE_01368"/>
    <dbReference type="KEGG" id="nev:NTE_01368"/>
    <dbReference type="HOGENOM" id="CLU_1369470_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="77"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="199" mass="23337" checksum="5E6173441EC0E11F" modified="2014-10-29" version="1">MELNDYYCRRMLASLEKRGKLGSNEFKRVMTAGPNPIMSERPFRERLRLLVEAGLVTRLPDKEDSGKVWYTLEPGILDNERALFNEIQERLEEMDRQYAQMEKNISAISTVDKAYQLSLAMRELASIEYRLWILKVIFRRNKRPKVLSKKIEELKGKLFHLTHIGNADKWTVQVILGVLERLEAELHRELVASQEEMTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPJ6</accession>
    <name>A0A075MPJ6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Purine nucleoside phosphorylase</fullName>
            <shortName evidence="5">PNP</shortName>
            <ecNumber evidence="5">2.4.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NTE_00642</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Purine nucleoside phosphorylase involved in purine salvage.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a purine D-ribonucleoside + phosphate = a purine nucleobase + alpha-D-ribose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:19805"/>
            <dbReference type="ChEBI" id="CHEBI:26386"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Purine metabolism; purine nucleoside salvage.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 5">Homohexamer. Dimer of a homotrimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="5">Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it lacks several conserved amino acids in the substrate binding pocket that confer specificity towards MTA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.1" evidence="5"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPJ6"/>
    <dbReference type="STRING" id="1459636.NTE_00642"/>
    <dbReference type="KEGG" id="nev:NTE_00642"/>
    <dbReference type="eggNOG" id="arCOG01327">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054456_0_2_2"/>
    <dbReference type="UniPathway" id="UPA00606"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017061">
        <property type="term" value="F:S-methyl-5-thioadenosine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09010">
        <property type="entry name" value="MTAP_SsMTAPII_like_MTIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1580:FF:000012">
        <property type="entry name" value="Probable 6-oxopurine nucleoside phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01963">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010044">
        <property type="entry name" value="MTAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018099">
        <property type="entry name" value="Purine_phosphorylase-2_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01694">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006334">
        <property type="entry name" value="PRK08564.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42679">
        <property type="entry name" value="S-METHYL-5'-THIOADENOSINE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42679:SF3">
        <property type="entry name" value="S-METHYL-5'-THIOADENOSINE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01240">
        <property type="entry name" value="PNP_MTAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5 7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3 5" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="6">
        <location>
            <begin position="8"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="57"/>
            <end position="58"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="90"/>
            <end position="91"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="213"/>
            <end position="215"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="5">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="5">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00063054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF82722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="267" mass="29642" checksum="F14D2E721EC8EBCB" modified="2014-10-29" version="1">MAMTEKADIGIIGGTGVYDSGLFSDKKEIKVHTPYGEPSDLITIGEYAGRKVAFLPRHGRGHRIPPHMINFRANIWALKQLGVKRIIAPSAVGSLGFDYKPGHIALPDQFIDFTKKREYTFYDGGQVAHVSMADPFCPEIRDVAAQVIERLKFPFQPKATYVCIEGPRFSTRAESKFFRDVMKADIIGMTLVPEVTLAREAEICYLSVATVTDYDVWAEIPVTSKEIIETLHKNVEKTKKLVAELIPAVPLERTKCACGNALEGSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPK3</accession>
    <name>A0A075MPK3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00657</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPK3"/>
    <dbReference type="KEGG" id="nev:NTE_00657"/>
    <dbReference type="eggNOG" id="arCOG08772">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_137737_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="192" mass="21716" checksum="197F6C67AD627359" modified="2014-10-29" version="1">MYAGVFGMSSLFNLSCCIFYHSIRIKLSHTIKHRLLGAKEQQDLGGAAGNIIQILANLPEFLRKPMLQKRLSEFFDMAEKERQETIALALAAAPTIDQQKLSVLVKTWLEVLAGFDAEKRTSIFEVYCSQIAKQPESLQRLNFRSLTDTFLSLGEKEREILADSFKEVLFAFPKREKVLAAVPDYSRKALGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPL8</accession>
    <name>A0A075MPL8_9ARCH</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1459636.NTE_00687"/>
    <dbReference type="KEGG" id="nev:NTE_00687"/>
    <dbReference type="eggNOG" id="arCOG00367">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR018977">
        <property type="entry name" value="NurA_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09376">
        <property type="entry name" value="NurA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00933">
        <property type="entry name" value="NurA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NurA" evidence="1">
        <location>
            <begin position="54"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="293" mass="32157" checksum="DA926A2CAC92E6C5" modified="2014-10-29" version="1">MLTLAVAVVFNELILDAIKNREAKLARLKDANHNHIIAEAKSRWVAHDAKPQVCMSAGVDSSWNKRALQGFDLYAIAAVAVTSTNEIIAKEWDNDIGGSIRAEQLESRAMEMESLVAQKAHASGMVKIVCVDGSLISRLLKSTPSVAVETVRKYGDAIFISKTSESRSQFGALGSRAGDIYYYRQATMQAGFSVPAQVQSRGGSVYEIYMRLRAGMPVLRVELIKGSSSSFASASEQEIRNMMDLLRYHSVSGYPYCLKLAHKNCKISNDDIDRLASIYGLQNEPGARDALNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPQ5</accession>
    <name>A0A075MPQ5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1326 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00754</name>
    </gene>
    <organism evidence="1 2">
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        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPQ5"/>
    <dbReference type="STRING" id="1459636.NTE_00754"/>
    <dbReference type="GeneID" id="41596606"/>
    <dbReference type="KEGG" id="nev:NTE_00754"/>
    <dbReference type="eggNOG" id="arCOG11393">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092801_0_0_2"/>
    <dbReference type="OrthoDB" id="6311at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009758">
        <property type="entry name" value="DUF1326"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014581">
        <property type="entry name" value="UCP033303"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07040">
        <property type="entry name" value="DUF1326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033303">
        <property type="entry name" value="UCP033303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="211" mass="23457" checksum="5558537460247A28" modified="2014-10-29" version="1">MTASVVEIPSWRTKSDYIETCNCDYGCPCNFNGYPTYGFCRALVLYPIREGHYGNDVKLDNIDVVYAASWPKAIHEGNGTMQLFISGNTTPEQRNAVVNIFSGKAKGEGPFSIFATTIKYMLEPQFVDINVKLDGKKSSFSVPGVLDVRLESFKNPVTCEEQDTKVQLPKGFVWKIADAAKSSVMRIMTPNLNFDDSGKNAYASTVEYRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPS2</accession>
    <name>A0A075MPS2_9ARCH</name>
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        <submittedName>
            <fullName evidence="3">C2H2 type zinc-finger (2 copies)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_01498</name>
    </gene>
    <organism evidence="3 4">
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        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPS2"/>
    <dbReference type="STRING" id="1459636.NTE_01498"/>
    <dbReference type="GeneID" id="41597287"/>
    <dbReference type="KEGG" id="nev:NTE_01498"/>
    <dbReference type="HOGENOM" id="CLU_2379516_0_0_2"/>
    <dbReference type="OrthoDB" id="11401at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041661">
        <property type="entry name" value="ZN622/Rei1/Reh1_Znf-C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12756">
        <property type="entry name" value="zf-C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF83561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="104" mass="11785" checksum="873B1CD4764D76E8" modified="2014-10-29" version="1">MADTSERRDENNNDAANNNSSKNVRVDEESSSAIPDSRQSFHGIEKVTADFQCFVCGAVFNTDEDRKQHLEKEAHGTLHEESTEEDMEIAKEQEELNESHAHHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPV4</accession>
    <name>A0A075MPV4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01533</name>
    </gene>
    <organism evidence="2 3">
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        <lineage>
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            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385225.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPV4"/>
    <dbReference type="STRING" id="1459636.NTE_01533"/>
    <dbReference type="GeneID" id="43502609"/>
    <dbReference type="KEGG" id="nev:NTE_01533"/>
    <dbReference type="HOGENOM" id="CLU_210074_0_0_2"/>
    <dbReference type="OrthoDB" id="373175at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="47" mass="5408" checksum="BD6206C4788D2274" modified="2014-10-29" version="1">MEQDSGTLLQDRLFYCERCSTVFLSDEDAHMHEKLLGHIMCHLAPEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPX0</accession>
    <name>A0A075MPX0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00829</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699781.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPX0"/>
    <dbReference type="STRING" id="1459636.NTE_00829"/>
    <dbReference type="GeneID" id="41596673"/>
    <dbReference type="KEGG" id="nev:NTE_00829"/>
    <dbReference type="HOGENOM" id="CLU_2257461_0_0_2"/>
    <dbReference type="OrthoDB" id="7362at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="103" mass="12190" checksum="2532B0F589D07E94" modified="2014-10-29" version="1">MTKQDGQWLNNIDGNWRDTRCPCGSTFHFRGKVDELFAWERIHLRHMASDSENHEMLSFYPKDMVIIYHASSGYVVERRKHRREEINEVHQARLYGNAKLAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPX3</accession>
    <name>A0A075MPX3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BED-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00836</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699786.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPX3"/>
    <dbReference type="STRING" id="1459636.NTE_00836"/>
    <dbReference type="GeneID" id="41596681"/>
    <dbReference type="KEGG" id="nev:NTE_00836"/>
    <dbReference type="HOGENOM" id="CLU_2766229_0_0_2"/>
    <dbReference type="OrthoDB" id="10983at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="68" mass="7505" checksum="F600333A4BB87FC1" modified="2014-10-29" version="1">MAAAYDEHIVKCSICGRALIVKDTVNNGVAFLSHLKIDHGITYFVQQMTTEEAKAAQKRTNQTLAPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPX5</accession>
    <name>A0A075MPX5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00841</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385065.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPX5"/>
    <dbReference type="STRING" id="1459636.NTE_00841"/>
    <dbReference type="GeneID" id="43502581"/>
    <dbReference type="KEGG" id="nev:NTE_00841"/>
    <dbReference type="HOGENOM" id="CLU_210694_0_0_2"/>
    <dbReference type="OrthoDB" id="11651at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="50" mass="5785" checksum="B17618E74B428017" modified="2014-10-29" version="1">MKETSGAPKDGHERIVADRDGGKHLEYFRNGSWRHDATRCKAKINKECRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQ66</accession>
    <name>A0A075MQ66_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed RNA polymerase subunit Rpo11</fullName>
            <ecNumber evidence="3">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">DNA-directed RNA polymerase subunit L</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpo11</name>
        <name evidence="3" type="synonym">rpoL</name>
        <name evidence="5" type="ORF">NTE_00946</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the RNA polymerase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="3"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385081.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQ66"/>
    <dbReference type="STRING" id="1459636.NTE_00946"/>
    <dbReference type="GeneID" id="41596781"/>
    <dbReference type="KEGG" id="nev:NTE_00946"/>
    <dbReference type="eggNOG" id="arCOG04111">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090381_5_0_2"/>
    <dbReference type="OrthoDB" id="6541at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00261">
        <property type="entry name" value="RNApol_arch_Rpo11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009025">
        <property type="entry name" value="RBP11-like_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022905">
        <property type="entry name" value="Rpo11-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13656">
        <property type="entry name" value="RNA_pol_L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3 5" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RBP11-like dimerisation" evidence="4">
        <location>
            <begin position="12"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF83022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="91" mass="10287" checksum="B2F6C057E30FFD92" modified="2014-10-29" version="1">MLAEITDFKDNELELKVREEDISILYIVQHELLKEKSVDFAGVMLQHPLTKDFKMRVVTKRKDPAEVIQDAAVSAADYSKELAGLVKAALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQC0</accession>
    <name>A0A075MQC0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Subtilase family protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NTE_01198</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700063.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="STRING" id="1459636.NTE_01198"/>
    <dbReference type="GeneID" id="41597007"/>
    <dbReference type="KEGG" id="nev:NTE_01198"/>
    <dbReference type="eggNOG" id="arCOG00704">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG03439">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003710_0_0_2"/>
    <dbReference type="OrthoDB" id="27270at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044016">
        <property type="entry name" value="Big_13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF11">
        <property type="entry name" value="CEREVISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19077">
        <property type="entry name" value="Big_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1562"/>
            <end position="1583"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="6">
        <location>
            <begin position="196"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="domain" description="Bacterial Ig-like" evidence="7">
        <location>
            <begin position="1393"/>
            <end position="1468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF19077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF83270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="1588" mass="167856" checksum="7B39C816270A1C96" modified="2014-10-29" version="1">MIRLAAVVILLALVASAFVAPAYSLAPSREQVLSGGISESRPLSSLPMQTPAANSDDTVASIFGRNVPKSAIRSDFGSINLGSLQYNGNVGRTLVLGPGDPQALAGAHVVGMGGSPTQGSFLGVAFSKNPLAQSGNGFGYATDTPLAFDSLPHNNNNNNNSNTLAGYDNNNSASGRLSGTSITGADRAASLYNATGDGVKVAIVDTGSDFSNPDMRDAVARDAKGVPIMLDSDGQGLVLTRAKYVANINQQTGVIMNYTTGSNGKVQLPENTTSYTYVNGTGVYLRTSEGRIPVYNMLYPTFGAPELSATANVDWKIGKSSTDYIRSMSGVYHFGVVYQATTKLGTISLTLIPVLVVDSTEPGVYDTIVADMSYGWYYFTLGIAGAFPQTNHLMPAQLTFDFTDEKPFKLGDGNEFLTYDYNKDGVPDYSAGIAGARVLDIWRITDNKTQVVVADKSGVSGAVSAKLLEPMDPDGNYFGLMFDFAGHGTSTAATVASRGHAQYDIYNNATRYTLAGMAPGAKIIPVKSLWMGDALYGWLWASGFDLKESDGRWAYTGSHKADVMSNSWGISNFPLLKYGPGYDILSVFSSLLMVPHALAKDYPGTLVVDSVGNNGLGYGSVGAPNTSPLAISVGATTNNVHLQYGPFANITRFGTSAASYDDVAEFSSRGPSLLGDPKPELMAVGSYGFTPTDVTMKNLESKEGDPNDDGAFALFGGTSMAAPMVAGAAALVVQEMNETGKAPDPFAVKSILMSTAKDLKNDPFVQGSGRVDALAAVQLALGDTGFSVYTDDTAKTIMDSLRPSILTYAPTLGIINNGYPVQIPGTVPATAIDGARETRWFAGRIEPGKKASTDVVIENPSKQKDLTVELSSTIEKLVARYEVKNATKLFLEDPTHSNKTFGYEPNYYDLTKLAGVEGGKLPDSDLMVARVNFPFSSFMNQTELFADHLRIASVYSYDWHDANKDGKISYAEIGMVNRGGAWGTTQEVRISDPKDKFTGTPVVGVYPVPTVFSFWSGDKLINSTSMNYTLTVELYKRMPNPDVQLDKSLVTVPPGGTAKVNATIAARNDTLSGIYFGEIMAKGPRNSVVMPVSYVVTTKPVPKDVPVVLSPPAAGSAQKQPESEIEGSLGLKPNGYVGGLSDMVSRYAAGDWRSYYFTVTDPTVTAMTLKVSWPHNSTSVNAMAYGPDGRMVASSVPAGVFQEFVSWPSNDWLGTSAVSEGGAFFFSQNAGERSTVLHVPVNATGIYSLLVHNTLFHGESLYEPLSVEAKFSTLLPDTTPPKLTADVPKFVRGDAVAVPVTIDDSNPAGLSYSVDGKAEPSSGNQVRIEGGTLAEGPHLLTIESKDTVGNLASSSWQFTVDKTPPATELFVRDGNNNSTDAIVAGKHLVVSKQATLAWNVTDANGVAGKVTVRLPDANNSTKPASYDPDSSMVFNSTALADGHYNFTISSRDLPGNKATRTWDLVVDNTPPKASVGVSGGDVQGITKVALGAQDENLKSATLSVGGNRMVVNVTGLGEYDLDTTGLPDGKYEVKLAALDTAGNEGTASATLTVANVQPMIEMVAILGVVGGLAGGAAIAWVIASRRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQD8</accession>
    <name>A0A075MQD8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700461.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQD8"/>
    <dbReference type="STRING" id="1459636.NTE_01685"/>
    <dbReference type="GeneID" id="41597457"/>
    <dbReference type="KEGG" id="nev:NTE_01685"/>
    <dbReference type="HOGENOM" id="CLU_184936_0_0_2"/>
    <dbReference type="OrthoDB" id="9475at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="84" mass="9461" checksum="64D8408F03E232D7" modified="2014-10-29" version="1">MNIADSEVAQLIIARTCGCNELGRRKVTYNFADPYHALCLDKKDIILAQLEACETLLKYASDDPDKKVVEKEIAELRMAMDLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQF6</accession>
    <name>A0A075MQF6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed RNA polymerase subunit Rpo7</fullName>
            <ecNumber evidence="4">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">DNA-directed RNA polymerase subunit E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpo7</name>
        <name evidence="4" type="synonym">rpoE</name>
        <name evidence="6" type="ORF">NTE_01705</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the RNA polymerase complex. Forms a stalk with Rpo4 that extends from the main structure.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="4">Forms 2 domains with an elongated structure; Rpo4 packs into the hinge region between the 2 domains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="4"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700476.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQF6"/>
    <dbReference type="STRING" id="1459636.NTE_01705"/>
    <dbReference type="GeneID" id="41597475"/>
    <dbReference type="KEGG" id="nev:NTE_01705"/>
    <dbReference type="eggNOG" id="arCOG00675">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117966_0_0_2"/>
    <dbReference type="OrthoDB" id="7927at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04331">
        <property type="entry name" value="RNAP_E_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04460">
        <property type="entry name" value="S1_RpoE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00865">
        <property type="entry name" value="RNApol_arch_Rpo7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004519">
        <property type="entry name" value="RNAP_E/RPC8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046399">
        <property type="entry name" value="RNApol_Rpo7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005576">
        <property type="entry name" value="Rpb7-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006333">
        <property type="entry name" value="PRK08563.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00448">
        <property type="entry name" value="rpoE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF4">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03876">
        <property type="entry name" value="SHS2_Rpb7-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88798">
        <property type="entry name" value="N-terminal, heterodimerisation domain of RBP7 (RpoE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 6" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4 6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S1 motif" evidence="5">
        <location>
            <begin position="82"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF83766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="200" mass="21506" checksum="5CF6DD37E4ED92C3" modified="2014-10-29" version="1">MFAIVHMSDVVRIPPSRLTNSLKDAAIQILKEKYESMLSPDVGYVVMITDAEVSSTGKLVAGDGATYHKVTFKALTFYPKLQEIVEGEVVEITDFGAFVRIGPTDALLHLSQITDDYLKSDVKQGVIVANQSSRALKIGSKIRARITAVSLGKGAGMGKIGITCRQPFLGALEWIQEEIKKGKSGEATAPAAPKEKKGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQG6</accession>
    <name>A0A075MQG6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700109.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQG6"/>
    <dbReference type="STRING" id="1459636.NTE_01250"/>
    <dbReference type="GeneID" id="41597056"/>
    <dbReference type="KEGG" id="nev:NTE_01250"/>
    <dbReference type="eggNOG" id="arCOG01055">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_159725_1_2_2"/>
    <dbReference type="OrthoDB" id="4292at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038723">
        <property type="entry name" value="ArnR1-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14947">
        <property type="entry name" value="HTH_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ArnR1-like winged helix-turn-helix" evidence="1">
        <location>
            <begin position="5"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="93" mass="10305" checksum="70EA1B9B04DE380D" modified="2014-10-29" version="1">MAPYRNSVKILGDVLQITEEHGIGGVNLTSLLRKANLSYGRLAAVAGRLIQAGMIQEQVLDGQRIYVITPQGKEYLHRYNQFAEMANSFGLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQW1</accession>
    <name>A0A075MQW1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01876</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700615.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQW1"/>
    <dbReference type="GeneID" id="41597635"/>
    <dbReference type="KEGG" id="nev:NTE_01876"/>
    <dbReference type="HOGENOM" id="CLU_2177770_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="109" mass="11825" checksum="DFE5832A072FC084" modified="2014-10-29" version="1">MVLDPPREQVNVKRMMIYSFIPFLSIYAGWRIQKFWLLTGINFGLGLVIGGLTGGIANSIDNYAASLAIIISGIAAEIAISLLLVKHYATEYNEKISAASGTESQSTTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQW4</accession>
    <name>A0A075MQW4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NTE_01426</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700250.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQW4"/>
    <dbReference type="STRING" id="1459636.NTE_01426"/>
    <dbReference type="GeneID" id="41597221"/>
    <dbReference type="KEGG" id="nev:NTE_01426"/>
    <dbReference type="eggNOG" id="arCOG01096">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038957_2_0_2"/>
    <dbReference type="OrthoDB" id="42847at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008217">
        <property type="entry name" value="Ccc1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31851">
        <property type="entry name" value="FE(2+)/MN(2+) TRANSPORTER PCL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01988">
        <property type="entry name" value="VIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF83490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="248" mass="26247" checksum="AF74D2972E5355A7" modified="2014-10-29" version="1">MAERVTHVEPHIKESNYIRDLVFGFGDGVNTSLGIVAGVGGAIISADVVILAALIGMFTGAKAMAVQNYLAVKSQREILESEIKREEHEIETVPELEREEVEDIYREKGFEGEELNRVVSKITSNKDVWLKTMLTEELGLNLEILGNPLKGALVMFGSFLLGGILPILPYFAVKAGLMSPIAAIVIAIVISVASSFIVGALKGRMAKKSWIKGGIEMAGLGTGIALVGYGIGAELAKAGIVSVPPAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MR05</accession>
    <name>A0A075MR05_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">NTE_01471</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700291.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MR05"/>
    <dbReference type="STRING" id="1459636.NTE_01471"/>
    <dbReference type="GeneID" id="41597264"/>
    <dbReference type="KEGG" id="nev:NTE_01471"/>
    <dbReference type="eggNOG" id="arCOG02358">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_62_2"/>
    <dbReference type="OrthoDB" id="342253at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06225">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000006">
        <property type="entry name" value="Sensor histidine kinase WalK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.350">
        <property type="entry name" value="CHASE domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006189">
        <property type="entry name" value="CHASE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042240">
        <property type="entry name" value="CHASE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050736">
        <property type="entry name" value="Sensor_HK_Regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43711:SF1">
        <property type="entry name" value="HISTIDINE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43711">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03924">
        <property type="entry name" value="CHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01079">
        <property type="entry name" value="CHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50839">
        <property type="entry name" value="CHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="CHASE" evidence="13">
        <location>
            <begin position="70"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="340"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="12">
        <location>
            <begin position="409"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AIF83535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="634" mass="70526" checksum="176C8F540C119E37" modified="2014-10-29" version="1">MQRDGLLIPFAALAVAVALTIFAWYTVTVFVNGIEQARFEDEVLATVFSINNRMQEYEQVLFGGKGLFASSQQVERAEWKAFVDNQMIQNRFPGVQGVGFVERVTAGELASHVASVRNEGFAGYVVRPDVQKEVYYPVVFIEPFDAKNRQALGFDISSEQVRNAAISRALESGQTTITGKITLVTETQSDMQSGFLMLVPVYENGMPAGTPDERRENIRGFVYAPFRMDDLMKGITGLAARDITFSIHDGQNQTTNENLMFDLSSVAGTRGGDIDRSLEKTVIMDIGGRQWTLEFAALRSIHSGFDIFIPYIVLVVGFTLSGVLFYVMYSASRQREETAELVWAAEEIARGNLDIRLDDNLLASQDRIGNLARVFDEMRKSVKAGTDDLKKMNEDLVRIDKMKEEFSSMVSHELKSPLTPIKFGADSLLDPESTGNLTEEQRGYARMVMRNATKMENLINDLMDSYKLDIDKLTFVMTENDIGQMVSQCVADLAPYAKDKAIKLEADTKASGTITCDRKRIDQVIANLVKNSVDFVPESGGRITVRAEDTGNKEVVFSVEDNGVGIRADKVDKLFEKFYQIDTTAKRKFGGSGLGLPISKGIVEAHGGRIWVDREYKGGAAIRFSLPRKSLQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MR08</accession>
    <name>A0A075MR08_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700043.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MR08"/>
    <dbReference type="STRING" id="1459636.NTE_01174"/>
    <dbReference type="GeneID" id="41596985"/>
    <dbReference type="KEGG" id="nev:NTE_01174"/>
    <dbReference type="HOGENOM" id="CLU_273275_0_0_2"/>
    <dbReference type="OrthoDB" id="386880at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="1178" mass="126801" checksum="F465620F49ABE0F2" modified="2014-10-29" version="1">MSTLAERYAAFQQANLAAQQQAIQTGQQQQITSSRDASGNVSFGYSPTGAPASPPTGSTPSPIGRIDRGAGGGGSGGSRASKTIIDVGNELQVRQEQEQAARQAAAGAAQNRSQGSKPGMVDYYRQQIEQSQVAAEQRRMAQQTTITVQHPPEYIGPYSRTSPGPMGFDPFKNARFEYDESGKVKNVTIGAQSDIGFDAKGIVKLEEKDGQQYAVYQPTEAETKRFYGYSESLTLPVGAMQTLLYGGFQAANRAAQEQALATGKPVTLTADKINEQALAMVKPGGKYESGIPIQQDQGDYQRWAYDVVKSGRNPPNELKTFGTLTVQEAREKFAGHNARNFQRYYIDPATGQPVDPFHSYAQQQAANERWANQVQNADWSAAYTAQRAGMRPTNPFALEMRNAAGFYGSMQIVGQYRPHSAEGKEPLVKDAPAPTPGFFGPVIDAAKGTKVEAENLVANLAYGAQGVAALLAPRQIPRRTLDLEGNEISRNIPKPPELKSGVGTDLSSLAIQSAYQLATTGKTDVKAADLQKIGENIIKNIPYAAGNLALEALSFIGPGLVTKGARVAQVGTTVSKAEEIAAMAAKRVGYQETTVQALGKAETPLTRGPFGTFWRPLWESGRVIYPKMEITGEAATLAAGKVQLKVPTMPEAFAIRAGADVTAPTIGRILPRAGEVRIATAPLSEEQKIALRGFEQPKVGQGPPAPRTLQPGELAAKDIKDYYGRGFTGAVAGKILGTDARVATEAADISLQKAAVSITGKTPKLGEFGLDLAEQLPQRTVRASPLIPVSSDVPLWSRVTFDLKEVKAAASALAKRASQVRGAEEALKDLPGTSANKTMRPFDFTPAAEVTKIGKTSLTPLERADAFTFDASLQEEASKAAEKSLSNALGASAAAALAASSAAGGFGYAAAAAETGPQQQETITDLAQVVAFPAPSSSGRGPPSMGEIFTNRVQMNLAKFVDNKPGQAVEQARKASENMINALAKMQNSKGTEKQIATQQLLGNLKLEGESDLDRALRKNIRETAIEKRGLQQLQTPVENSQRFLKQITNFGESRDTGSLIRSQQTQIPVQTPAELFKLQQQLATRFDFHGLPRVPPERRPPDFPPFFLPETTGKYARASRREQSNYFERLFAVPDPLVAVFGTKQAKRLPGYRMDDYGDYLREFLPGSKKSRSRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MR28</accession>
    <name>A0A075MR28_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01948</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700663.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MR28"/>
    <dbReference type="STRING" id="1459636.NTE_01948"/>
    <dbReference type="GeneID" id="41597695"/>
    <dbReference type="KEGG" id="nev:NTE_01948"/>
    <dbReference type="HOGENOM" id="CLU_2581534_0_0_2"/>
    <dbReference type="OrthoDB" id="6387at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="80" mass="9387" checksum="FA10E1F524E040D6" modified="2014-10-29" version="1">MTLLWRDPWLKPLTDGDVGTENCAFCKKEFKEIEFVTACDFCDFGIMHDSCANKHTLQKHRKELESKISSHKDKPLHDYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MR57</accession>
    <name>A0A075MR57_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Muconolactone delta-isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01517</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700325.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MR57"/>
    <dbReference type="STRING" id="1459636.NTE_01517"/>
    <dbReference type="GeneID" id="41597304"/>
    <dbReference type="KEGG" id="nev:NTE_01517"/>
    <dbReference type="HOGENOM" id="CLU_1987691_0_0_2"/>
    <dbReference type="OrthoDB" id="8109at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1060">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026029">
        <property type="entry name" value="MLI_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02426">
        <property type="entry name" value="MIase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Muconolactone isomerase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="113" mass="12513" checksum="C24EEFE799CFCF87" modified="2014-10-29" version="1">MLFLVIDTVKLEFVGPEVAVAQMKMLQQTFATYQELKEQGKIKFAYAFADSPGGIIVLDVASNDELQQVLFLLPSMPLVQRTVRPLTEIKSVEGIVSELQTIVSSMPNPEKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRD4</accession>
    <name>A0A075MRD4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Succinate dehydrogenase, hydrophobic anchor subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NTE_01592</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148702072.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRD4"/>
    <dbReference type="STRING" id="1459636.NTE_01592"/>
    <dbReference type="GeneID" id="41597372"/>
    <dbReference type="KEGG" id="nev:NTE_01592"/>
    <dbReference type="eggNOG" id="arCOG04162">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2067882_0_0_2"/>
    <dbReference type="OrthoDB" id="10105at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase, transmembrane subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000701">
        <property type="entry name" value="SuccDH_FuR_B_TM-su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01127">
        <property type="entry name" value="Sdh_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="Fumarate reductase respiratory complex transmembrane subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="5"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF83655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="109" mass="12064" checksum="00F126BF53906FBE" modified="2014-10-29" version="1">MKIHYITGIAAIFVVAVHIMMRLVMPYGLSLEYANVIANYHNVPYIMLLESILVLIAIHGFNGLRIILLEMRQSKNWEGMVTAVTIAAMIGIVAYGTRTIIVVNGFSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRH6</accession>
    <name>A0A075MRH6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative RNA-binding protein, contains TRAM domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01697</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRH6"/>
    <dbReference type="STRING" id="1459636.NTE_01697"/>
    <dbReference type="KEGG" id="nev:NTE_01697"/>
    <dbReference type="eggNOG" id="arCOG01641">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_182721_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRAM" evidence="1">
        <location>
            <begin position="30"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="100" mass="11149" checksum="FA651838735863F4" modified="2014-10-29" version="1">MNNFYSLYREQCLRSIRMSYGRRDNFGPKPVEMGKEYDVQITEISRKGDGIARIQGFVIFVKDGKVGQNAKIRVTQIGPRFATAEVVNGAAATTTDNPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRP3</accession>
    <name>A0A075MRP3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphopantetheine adenylyltransferase</fullName>
            <ecNumber evidence="7">2.7.7.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Dephospho-CoA pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Pantetheine-phosphate adenylyltransferase</fullName>
            <shortName evidence="7">PPAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">coaD</name>
        <name evidence="9" type="ORF">NTE_01423</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(R)-4'-phosphopantetheine + ATP + H(+) = 3'-dephospho-CoA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19801"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57328"/>
            <dbReference type="ChEBI" id="CHEBI:61723"/>
            <dbReference type="EC" id="2.7.7.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cofactor biosynthesis; coenzyme A biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the eukaryotic CoaD family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.3" evidence="7"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRP3"/>
    <dbReference type="STRING" id="1459636.NTE_01423"/>
    <dbReference type="KEGG" id="nev:NTE_01423"/>
    <dbReference type="eggNOG" id="arCOG01223">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035272_5_0_2"/>
    <dbReference type="OrthoDB" id="53228at2157"/>
    <dbReference type="UniPathway" id="UPA00241"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004595">
        <property type="term" value="F:pantetheine-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00647">
        <property type="entry name" value="PPAT_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050385">
        <property type="entry name" value="Archaeal_FAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023540">
        <property type="entry name" value="PPAT_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001985">
        <property type="entry name" value="PRK00777.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43793">
        <property type="entry name" value="FAD SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43793:SF1">
        <property type="entry name" value="FAD SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 7 9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="8">
        <location>
            <begin position="9"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF83487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="156" mass="16916" checksum="CA64492ECA11F9F4" modified="2014-10-29" version="1">MKRFRVVATGGTFDEIHAGHIALLSKAFEVGDKVIIGVTSDEFVKGKKKINHDFSRRIANLKDMIRKEFGDNANYEIAKLDSEFGPAVTTGDVGALVASAETQEKGARLNEIRRKNGLAPAQVISVPLIKAEDGKPISSTRIRAGEIDKSGRLLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRR0</accession>
    <name>A0A075MRR0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Translation initiation factor 6</fullName>
            <shortName evidence="3">aIF-6</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">eif6</name>
        <name evidence="4" type="ORF">NTE_00015</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eIF-6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699170.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRR0"/>
    <dbReference type="STRING" id="1459636.NTE_00015"/>
    <dbReference type="GeneID" id="41595969"/>
    <dbReference type="KEGG" id="nev:NTE_00015"/>
    <dbReference type="eggNOG" id="arCOG04176">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071894_1_0_2"/>
    <dbReference type="OrthoDB" id="33582at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.75.10.10">
        <property type="entry name" value="L-arginine/glycine Amidinotransferase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00032">
        <property type="entry name" value="eIF_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002769">
        <property type="entry name" value="eIF6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00323">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10784">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01912">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006413">
        <property type="entry name" value="IF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00654">
        <property type="entry name" value="eIF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55909">
        <property type="entry name" value="Pentein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3 4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2 3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF82099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="221" mass="23747" checksum="6A5978B113C5E5FD" modified="2014-10-29" version="1">MAIYRYTVYKSPNIGIFIRANDKVMLIPHGFAETKTEKLSEYLQVEEVHASVAGTRLLGPMTVMNNNGILLPPIAEEEEVQFLRERTRLRVERVKSKFTAVGNLIAANDNGAIVSPLLESEVDEQVRDVLGVPAHRMEVGGFVQAGSMIVATNAGAGVHPKATEEEVKAVSEALQVPAEPLTINGGVPFLSSGIVANTKAVVVGSLTSGPELIMLSRIFQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MS29</accession>
    <name>A0A075MS29_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01554</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MS29"/>
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    <dbReference type="GeneID" id="41597336"/>
    <dbReference type="KEGG" id="nev:NTE_01554"/>
    <dbReference type="HOGENOM" id="CLU_2165352_0_0_2"/>
    <dbReference type="OrthoDB" id="12284at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="93"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="122" mass="14278" checksum="AF423FFE2C3112B6" modified="2014-10-29" version="1">MKRRKIKPDRKVRPRNEITGQEVETFLSAIRGFENGHYPKLRDLRTLIPSMDLYKINVILRYLERSKAIIVDNDGYIVWTRKDAPDQLTLGDVADISDDLKKFLEEKKQEEGEAEEEEEGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MS91</accession>
    <name>A0A075MS91_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nicotinamidase-like amidase</fullName>
            <ecNumber evidence="3">3.5.1.110</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_00137</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
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            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.1.110" evidence="3"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MS91"/>
    <dbReference type="STRING" id="1459636.NTE_00137"/>
    <dbReference type="KEGG" id="nev:NTE_00137"/>
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068979_8_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00431">
        <property type="entry name" value="cysteine_hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
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    </dbReference>
    <dbReference type="InterPro" id="IPR050272">
        <property type="entry name" value="Isochorismatase-like_hydrls"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540:SF6">
        <property type="entry name" value="ISOCHORISMATASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540">
        <property type="entry name" value="PEROXYUREIDOACRYLATE/UREIDOACRYLATE AMIDOHYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="2">
        <location>
            <begin position="11"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF82219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="224" mass="25157" checksum="005D3A57683ECCBC" modified="2014-10-29" version="1">MLLKGQEVHPALLVIDVQNCFMSEGGSYDILGINISDYNRVLPNICSMVSLCRDKGIPIFYMMAVREPSGVDLLTKTHKFLPKPREERIESAPICVKGTWDADIIDSIKKSVDTSSPNVIIKRRDSAFFGTELDKKLCDLKVDTVIICGVDTSICVETSLRDAFNLGYDVVLVSDATASMDAKRYECTLEDVRNFFGLVLDSKSLLKEVGQQVPEKDYYHLYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSB6</accession>
    <name>A0A075MSB6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator with CheY-like receiver, AAA-type ATPase, and DNA-binding domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_00162</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSB6"/>
    <dbReference type="STRING" id="1459636.NTE_00162"/>
    <dbReference type="KEGG" id="nev:NTE_00162"/>
    <dbReference type="eggNOG" id="arCOG02391">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_15_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050595">
        <property type="entry name" value="Bact_response_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44591:SF3">
        <property type="entry name" value="RESPONSE REGULATORY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44591">
        <property type="entry name" value="STRESS RESPONSE REGULATOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="2"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF82244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="133" mass="15383" checksum="485B33BEBD00601C" modified="2014-10-29" version="1">MRILVAEDEPNILLMYRVFLEGEGNEVTTARDGEECLHHYMLSDHQNKPFDVVILDYRMPKMNGRDVAKEILARHSGQTIIMITAFSKELTDFSGIEKIEVLQKPFELEDLTRLLMKLFEPKIHSTSFDQAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSI0</accession>
    <name>A0A075MSI0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02487</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSI0"/>
    <dbReference type="STRING" id="1459636.NTE_02487"/>
    <dbReference type="KEGG" id="nev:NTE_02487"/>
    <dbReference type="HOGENOM" id="CLU_2140090_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="112" mass="12900" checksum="204B089F180DDE7B" modified="2014-10-29" version="1">MHGRYIYLWWRRGVSAFDDNPYSVHFAHFASKLEQYLRKNGISCDDADMIIEESSAIYFEKLGSSTNRLLKAFKKQDPADVFVDSAHKAIERHIPEAKDTFGSTAEISKLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSN4</accession>
    <name>A0A075MSN4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700777.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSN4"/>
    <dbReference type="GeneID" id="41597827"/>
    <dbReference type="KEGG" id="nev:NTE_02094"/>
    <dbReference type="HOGENOM" id="CLU_2839494_0_0_2"/>
    <dbReference type="OrthoDB" id="372339at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="65" mass="7861" checksum="D2DEE14A7218087D" modified="2014-10-29" version="1">MSSIKYKVNHNPITYDHRTKMYQVGNRVFETYQDARANQWQCDKCSDAFFSFKELRLHKNKAHAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MST0</accession>
    <name>A0A075MST0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ferritin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02587</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="41598281"/>
    <dbReference type="KEGG" id="nev:NTE_02587"/>
    <dbReference type="HOGENOM" id="CLU_1850702_0_0_2"/>
    <dbReference type="OrthoDB" id="7962at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="143" mass="16041" checksum="E4FEF0C58761DE4F" modified="2014-10-29" version="1">MDPRLKQLEKKQKLYSLLKAQHEAEVKELMHYMSVLTTVENNLVRSYLHTLLSDGLRHIEYISRIMADIEGATGSASLTKKGIEESIADERESHDALLKCAEMADDPETAALLKSISVDEEHHMRILEHLSELVESAAAGTTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSV0</accession>
    <name>A0A075MSV0_9ARCH</name>
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        <submittedName>
            <fullName evidence="2">Putative phosphoesterase, ICC</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">NTE_02171</name>
    </gene>
    <organism evidence="2 3">
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        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
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            <taxon>Nitrososphaerota</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385390.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSV0"/>
    <dbReference type="STRING" id="1459636.NTE_02171"/>
    <dbReference type="GeneID" id="41597895"/>
    <dbReference type="KEGG" id="nev:NTE_02171"/>
    <dbReference type="eggNOG" id="arCOG01150">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075478_0_0_2"/>
    <dbReference type="OrthoDB" id="10013at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07391">
        <property type="entry name" value="MPP_PF1019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39323">
        <property type="entry name" value="BLR1149 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39323:SF1">
        <property type="entry name" value="BLR1149 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="1">
        <location>
            <begin position="20"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="254" mass="27770" checksum="7632E14ECCCAF73E" modified="2014-10-29" version="1">MKVRPLHPHAALLAEDEARRYVVVSDLHIGLEAELGARGITVQSSLMREMQEELLSILSKEKADGLILLGDIKNTVGAISKQEWDDIPAFFKSLSSAADVYLVPGNHDSNIRHLVPDSVNVAASKGMAIGDTLFVHGHSMPSETRSHVRRIVMGHVHPVFLKKGSVVSGERVWISIQAKKEALFPSEQGAIDIVVVPSFNKYLYSSGERGYHHRKSVSPITSRIMDANAVERCMVITLDGSIVGDDESMLASVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSY8</accession>
    <name>A0A075MSY8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01847</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSY8"/>
    <dbReference type="STRING" id="1459636.NTE_01847"/>
    <dbReference type="KEGG" id="nev:NTE_01847"/>
    <dbReference type="eggNOG" id="arCOG08726">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2010013_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="122" mass="13935" checksum="ABA5263587D4F302" modified="2014-10-29" version="1">MPLPYGALDYYQVHYIVQTGDDVNTQKFLARCEPITKGHFSEKRVVAVKWTGASAFADKLQQDERLTELLKQVLLHEREVRVDPLDGHVRIYGRWNHDENLKANPVMVEIADIIAGHIKAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MT00</accession>
    <name>A0A075MT00_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01857</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700601.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MT00"/>
    <dbReference type="STRING" id="1459636.NTE_01857"/>
    <dbReference type="GeneID" id="41597619"/>
    <dbReference type="KEGG" id="nev:NTE_01857"/>
    <dbReference type="HOGENOM" id="CLU_175243_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="107" mass="12086" checksum="99D37ECCAD2CAF54" modified="2014-10-29" version="1">MPRKLTETEKLKIVRRAAKQKRLAEKAVKARADELSRLEEIKQAEAQHAEFEQARQRYLAESESAASLNESRMLKSMEKAKSKIGITGKSTVTFFRTSTQPGVPLPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MT18</accession>
    <name>A0A075MT18_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01883</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MT18"/>
    <dbReference type="STRING" id="1459636.NTE_01883"/>
    <dbReference type="KEGG" id="nev:NTE_01883"/>
    <dbReference type="HOGENOM" id="CLU_2930028_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="60" mass="6927" checksum="0DCA764369B8694F" modified="2014-10-29" version="1">MYSEQTTLKRLTCGKCAYEWLYKGRSPFWTSCPRCRTNVKTNVDGMAGLAEFNKKEAVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MT41</accession>
    <name>A0A075MT41_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00407</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MT41"/>
    <dbReference type="STRING" id="1459636.NTE_00407"/>
    <dbReference type="KEGG" id="nev:NTE_00407"/>
    <dbReference type="HOGENOM" id="CLU_1340767_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="197" mass="22069" checksum="82CDB334D8D2245B" modified="2014-10-29" version="1">MIVADSHMAMVLPDDISERISAFVAGKRAFPFIEKDELACIMYLYGRSAGVRHEEVAEAAALAQRTAGQVSIDIDSYLNSSAGKLDSEYIRSKYLNRELQLAVEKKNSSGAGRLAGDPAIISDCFAQHVAFYKQDYFFGLYGPLKEGELTADIRSMLLGRMIMVCYNRKSEQELGSHPLIPVYVWFKERLQRQSSNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTA9</accession>
    <name>A0A075MTA9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">OBG-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_02760</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RelA/SpoT family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148702164.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTA9"/>
    <dbReference type="STRING" id="1459636.NTE_02760"/>
    <dbReference type="GeneID" id="41598449"/>
    <dbReference type="KEGG" id="nev:NTE_02760"/>
    <dbReference type="eggNOG" id="arCOG00357">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037276_1_0_2"/>
    <dbReference type="OrthoDB" id="5875at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01669">
        <property type="entry name" value="TGS_MJ1332_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01899">
        <property type="entry name" value="Ygr210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000002">
        <property type="entry name" value="GTP pyrophosphokinase (RelA/SpoT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013646">
        <property type="entry name" value="YGR210-like_G4"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007171">
        <property type="entry name" value="PRK09602.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305">
        <property type="entry name" value="OBG GTPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305:SF1">
        <property type="entry name" value="OBG-TYPE G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08438">
        <property type="entry name" value="YGR210-like_G4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="3">
        <location>
            <begin position="1"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="4">
        <location>
            <begin position="326"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF84801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="400" mass="42881" checksum="A0CC23885054D7E0" modified="2014-10-29" version="1">MIIGLIGKANVGKSTFFNAATELAVPAANYPFTTIEPNVGVAYARVKCVCREFGVQDNPVHSMCIDGNRFIPVKLIDVAGLVPGAHAGKGLGNKFLDDARQADVLIHVVDASGSTDSAGKTVPAGTGDPMFDINFVEEEFDLWMAGIVSRDWSKTAREAENQGQKLEQMLAKRLSGLAIPEHQIFAAVHESGLASKKPTLWSEADILHFCKVLRAKAKPFLVAANKADLPTAEANIDRMKKAGLTVVPCASEAEAMLKKASKKGILHYLPGDDSFDVKPDVALNDQQKKALDIVRALIEKYGSTGVQEAINIACFDLLHLVAVYPVEDEFKLADKKGNVLPDVRLLPTGSTAKDLAGTVHADLAKGFLYAVDARTKQRIGADHQLKSGDVIKIVSASSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTE1</accession>
    <name>A0A075MTE1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Proteasome subunit beta</fullName>
            <ecNumber evidence="9">3.4.25.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">20S proteasome beta subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Proteasome core protein PsmB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">psmB</name>
        <name evidence="11" type="ORF">NTE_02325</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.25.1" evidence="9"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700959.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTE1"/>
    <dbReference type="STRING" id="1459636.NTE_02325"/>
    <dbReference type="GeneID" id="41598041"/>
    <dbReference type="KEGG" id="nev:NTE_02325"/>
    <dbReference type="eggNOG" id="arCOG00970">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035750_7_2_2"/>
    <dbReference type="OrthoDB" id="6330at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02113_A">
        <property type="entry name" value="Proteasome_B_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019983">
        <property type="entry name" value="Pept_T1A_Psome_bsu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03634">
        <property type="entry name" value="arc_protsome_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF0">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE SUBUNIT HSLV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0645">Protease</keyword>
    <keyword evidence="7 9 11" id="KW-0647">Proteasome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0888">Threonine protease</keyword>
    <keyword evidence="8 9" id="KW-0865">Zymogen</keyword>
    <feature type="propeptide" id="PRO_5005001787" description="Removed in mature form; by autocatalysis" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023362651" description="Proteasome subunit beta" evidence="9">
        <location>
            <begin position="20"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9 10">
        <location>
            <position position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIF84378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="219" mass="24160" checksum="B07080D896923AD0" modified="2014-10-29" version="1">MHPKDNRYPEYIAEQIKKGTTTCALTCKDGVVLAADTRASAGFFIADRHVMKIQKVDNHLAMTIAGGVADAQNLVDTMRYNANIFRLENKENIPVKSAARLCSNILFNNRYFPYYVQIIMAGYTNEEGGRIYNIDLFGSLTTEKFISTGSGSPVAYGYLEPEYKEGMSVNDAYKVAMQAIAAAIRRNAGTGDNINVAIIDKDGYRELSKEQKAAVGVVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTH2</accession>
    <name>A0A075MTH2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">3-oxoacyl-[acyl-carrier-protein] reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_02873</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701403.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTH2"/>
    <dbReference type="STRING" id="1459636.NTE_02873"/>
    <dbReference type="GeneID" id="41598553"/>
    <dbReference type="KEGG" id="nev:NTE_02873"/>
    <dbReference type="eggNOG" id="arCOG01259">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_2"/>
    <dbReference type="OrthoDB" id="24596at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005559">
        <property type="entry name" value="PRK07231.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF115">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE FABG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF84911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="254" mass="26858" checksum="6E2C1CB061BF214B" modified="2014-10-29" version="1">MVLLQGKVAIVTGAGGGVGRAIVKRLVSEGCKVVLIGRNRDRLAKAAAEAGNKENTLTVAADITKEAEVLSAVEQTISSFDRIDILVNNAGSINDPVCFHEMTEDQWSGLVDTNLIGTFQMTKAVIPVMMNGNKGGSIVNVSSVLGIRSIPKVPLAVYGATKAGVIMFTRSIAVEYGQYGIRSNCVAPSTIRSSMIEPYLQDENAKKVLESTFPLRKIGEPEDVASAVSYLASDDAKWVTGTILVVDGGVTAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTK0</accession>
    <name>A0A075MTK0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Succinate dehydrogenase/fumarate reductase flavoprotein subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NTE_00538</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699555.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTK0"/>
    <dbReference type="STRING" id="1459636.NTE_00538"/>
    <dbReference type="GeneID" id="41596409"/>
    <dbReference type="KEGG" id="nev:NTE_00538"/>
    <dbReference type="eggNOG" id="arCOG00571">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014312_8_1_2"/>
    <dbReference type="OrthoDB" id="23539at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.700.10:FF:000005">
        <property type="entry name" value="Succinate dehydrogenase flavoprotein subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.100">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE 2 FLAVOPROTEIN SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632:SF51">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000171">
        <property type="entry name" value="SDHA_APRA_LASPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="7">
        <location>
            <begin position="15"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal" evidence="8">
        <location>
            <begin position="469"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="430"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="439"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000171-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF82619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="624" mass="69440" checksum="C9E3DB8A6FB4BBE1" modified="2014-10-29" version="1">MADHAKKESNYFLCDVLVLGGGSAGLRAAIAAHDAGTNVLIVSRSKRGDPHTTLARGGINAALGTMDPEDNWMVHASDTLREGEFIADYEKVEVLCKNAPDAIMELVNWGARFHREKDGRLTQRFFGAHTYRRTVFYGDSTGQEIIRVLMEQVNQRKIKMIDNVYITKLLKSNDSSNNDDGNDDDDYHGEVNGALGIDIENKGLVRFVCKSLVIAAGGYTRVYPVSSSRLFENYGEGVALAYEAGVDLVDMEMVQFHPTGMVWPEKAVGVLATEAIRGEGGILLNSKGERFMKNYDPERMELAPRDVVARANYNEIISGRGTEHGGVWLDVTHLRKEVIQDRLPTMYQQFLELDGIDISKEKMEVAPTAHYSMGGVVADIKCRTRIRGLFAVGEVISQIHGANRLGGNSLLDTMVFGKIAGEEAARLAKQQKEGVAGEGGREDAKKTNDDDNYHDEGIIFVVKEPIKFHNEIQEIMKQNAGIIREETRLQNGLKGILELKDKFYSKDNIVEVSKVDDNNSENIVMTLQVKSSLVACEAIIRSALMRQESRGAHHRSDFPKLDDERWKANIYCRKKEGKEVSGTAFVAAEAAEMVLFKQNVKEIKGPLSDFLKVHVKAAHQREFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTN5</accession>
    <name>A0A075MTN5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02501</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701104.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTN5"/>
    <dbReference type="GeneID" id="41598205"/>
    <dbReference type="KEGG" id="nev:NTE_02501"/>
    <dbReference type="HOGENOM" id="CLU_2313877_0_0_2"/>
    <dbReference type="OrthoDB" id="11467at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="101" mass="11047" checksum="DD0012491DCE7891" modified="2014-10-29" version="1">MSSEDRSYEEGAAGTEKKRKGDPLKEYEEKEPMTPAKIKEHEPTAVKRDSSDQKIVERGQEGTDPERAKEIARSKGMAKGTAGAWKSGDEYEQGAAGTSTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTV7</accession>
    <name>A0A075MTV7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">rRNA biogenesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_00624</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NOP5/NOP56 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699622.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTV7"/>
    <dbReference type="STRING" id="1459636.NTE_00624"/>
    <dbReference type="GeneID" id="41596487"/>
    <dbReference type="KEGG" id="nev:NTE_00624"/>
    <dbReference type="eggNOG" id="arCOG01923">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015495_1_2_2"/>
    <dbReference type="OrthoDB" id="11877at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.90:FF:000007">
        <property type="entry name" value="Pre mRNA splicing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045056">
        <property type="entry name" value="Nop56/Nop58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047099">
        <property type="entry name" value="Nop5_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894">
        <property type="entry name" value="NUCLEOLAR PROTEIN 5 NUCLEOLAR PROTEIN NOP5 NOP58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nop" evidence="3">
        <location>
            <begin position="262"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="379"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="379"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="411"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="425"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF82704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="441" mass="48845" checksum="5E085F5D972DECC8" modified="2014-10-29" version="1">MSSSNSSCSVVLLELGIAAFDGAGNVVASRKFDSALRSYRMLKSGGTPEEIKPFVDQLRSYNTISVNDASVAIVLRQAGLANAQMMQEAQQQEIQGSKPDYIVKAGFAASPQDAMQALRDFAIDLSSSRVKEASEKLDLHIVQSINALDELDKIINTIGTRMREWYGLHYPELDNLVQSQVAHAEIISRAGSRDKITKEILESAGIQDKKAEIILDGARRSRGGDMTPENLAIVKKLADQVILQSDLRRILSDHIEAAMEVVAPNVKELLTAAVGARLIAKAGSLARLAVLPASTIQVLGAEKALFRALKTGARPPKHGILFQHPLIHSAPKWQRGKIARAVASKVAIAARIDYYRHAGKDTQITEKLNTRLEEIREKYKEPVPEKERDKKYREHERRQDRGPRRFGGGGGRDRRQEGGRDRFGGGKKKGKDRKRFGKRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTX3</accession>
    <name>A0A075MTX3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_02148</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700818.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTX3"/>
    <dbReference type="STRING" id="1459636.NTE_02148"/>
    <dbReference type="GeneID" id="41597873"/>
    <dbReference type="KEGG" id="nev:NTE_02148"/>
    <dbReference type="eggNOG" id="arCOG03911">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2165347_0_0_2"/>
    <dbReference type="OrthoDB" id="53394at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018649">
        <property type="entry name" value="SHOCT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09851">
        <property type="entry name" value="SHOCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="SHOCT" evidence="2">
        <location>
            <begin position="96"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF84202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="135" mass="15714" checksum="1454A5035C41A8E4" modified="2014-10-29" version="1">MSYQGPNRIRQIAGWSIIGVIAAVVMTIASIAIYSYLVPRPPGAFYYPFFPFHFGWLGGIFLIFAGLWIARWLLWPWRRGWGGYYYYYPRQQGADAVSIVRERYARGEITKEQFEQMLCDLRGQDGAQSTHEHRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MU34</accession>
    <name>A0A075MU34_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00726</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MU34"/>
    <dbReference type="KEGG" id="nev:NTE_00726"/>
    <dbReference type="eggNOG" id="arCOG08805">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100103_1_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="230" mass="25901" checksum="BBC9F9A7066E358F" modified="2014-10-29" version="1">MPEPYPRVITHEKQADCPALAPYVLVNIVTVSIIAIPCIHVQIHMYETDPKHGVHSEDSINATFRVNASVMKKLRAESEKRQTSLNAYINQVLLQHVEWDLFESRIGMMPFPKPVLANIFASLSTEEIKMLATGIGKNTAIEMSIFVQGRFNVETFISWIETRMKNSGCEVVYHTGGDDGARKTIVIKHDLGKNWSLYMKTMIESALEEVLGKVSNSFISDSLVSLEYKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MU75</accession>
    <name>A0A075MU75_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_00796</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699757.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MU75"/>
    <dbReference type="STRING" id="1459636.NTE_00796"/>
    <dbReference type="GeneID" id="41596646"/>
    <dbReference type="KEGG" id="nev:NTE_00796"/>
    <dbReference type="eggNOG" id="arCOG00235">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028458_3_3_2"/>
    <dbReference type="OrthoDB" id="6242at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000002">
        <property type="entry name" value="2-hydroxyhepta-2,4-diene-1,7-dioate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051121">
        <property type="entry name" value="FAH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42796:SF4">
        <property type="entry name" value="FUMARYLACETOACETATE HYDROLASE DOMAIN-CONTAINING PROTEIN 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42796">
        <property type="entry name" value="FUMARYLACETOACETATE HYDROLASE DOMAIN-CONTAINING PROTEIN 2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="81"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF82874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="291" mass="32159" checksum="0F95B897A3A64742" modified="2014-10-29" version="1">MKIARISTKGGRETYALVSPEGDGGMATRDEVERQAGVKLPAALEDFVFGDYAQKVTTGKISYAHKPGEFRLLPPIRRTFKIICLAFNYSDQASWVRFGKSPPKDPVIYLKPRTSLCGPADDIACPKSVTQLDYEGELAVVIGKECRNMSEETALGCVAGYFVINDISARDVQFIDKQYTRAKGFDTFGPCGPWLTTKDEIADPCDLRLTTRVNGEVRQDSSTKNLVLKIDRIIHSLSKVMTLEPGDIISTGTPSGTVLSLSSHVKYLQHGDVVEVEIEKLGRIKNRVTFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MU86</accession>
    <name>A0A075MU86_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02682</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701245.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MU86"/>
    <dbReference type="GeneID" id="41598372"/>
    <dbReference type="KEGG" id="nev:NTE_02682"/>
    <dbReference type="eggNOG" id="arCOG08818">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1182846_0_0_2"/>
    <dbReference type="OrthoDB" id="7396at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="234" mass="25740" checksum="D58CBD988901A87D" modified="2014-10-29" version="1">MRLLRPALAVFGFLVIVLVPLQQALGQEEIQPTNVIKSPKDESFVLPYQAANRDIRNPVVYKYDQSKGQNWIFTVDDKLSYVPRNDSKVVITIKEPAPSEKYIQIFMYGGDEQKFVVAVNAPQTGYQIIESGNWVYEELVTLTHSDNSGLTVTDGKRIVVDRLDIQGFNPASIEVYGMDEAGALANAYGGTLGIGILYGSPSDTPIYYVPAAVMIGVGALMGVLLWKKKRSSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MU87</accession>
    <name>A0A075MU87_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphoserine phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NTE_00821</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 3/3.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.3" evidence="3"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699775.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MU87"/>
    <dbReference type="STRING" id="1459636.NTE_00821"/>
    <dbReference type="GeneID" id="41596665"/>
    <dbReference type="KEGG" id="nev:NTE_00821"/>
    <dbReference type="eggNOG" id="arCOG01158">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1259134_0_0_2"/>
    <dbReference type="OrthoDB" id="10041at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036424">
        <property type="term" value="F:L-phosphoserine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050582">
        <property type="entry name" value="HAD-like_SerB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01488">
        <property type="entry name" value="HAD-SF-IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43344">
        <property type="entry name" value="PHOSPHOSERINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43344:SF2">
        <property type="entry name" value="PHOSPHOSERINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12710">
        <property type="entry name" value="HAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0718">Serine biosynthesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF82899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="220" mass="23765" checksum="29C1E778D9753480" modified="2014-10-29" version="1">MAQLAAFDMDGTLLDGRLVFALAERFGLDGKVRSVQADSKLVNYEKTIAIAALFAGLTRQDLLAAIESVPLAANCERAISLLKEQGWKVGIITDSYATAASVVAERLRMDFLAANELEFKGDKITGTVHMPLGWQEIGCTCKLSVCKRFHLEKYATKFGVPLENTAAIGDTRADICMVRRAGAGIAFMPKDDDIASATKSVVRKPDMMQVAQLLLLGAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUB5</accession>
    <name>A0A075MUB5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent DNA helicase Hel308</fullName>
            <ecNumber evidence="10">5.6.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">DNA 3'-5' helicase Hel308</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">hel308</name>
        <name evidence="13" type="ORF">NTE_02733</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the helicase family. Hel308 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="10"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701290.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUB5"/>
    <dbReference type="STRING" id="1459636.NTE_02733"/>
    <dbReference type="GeneID" id="41598423"/>
    <dbReference type="KEGG" id="nev:NTE_02733"/>
    <dbReference type="eggNOG" id="arCOG00553">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006553_3_0_2"/>
    <dbReference type="OrthoDB" id="371946at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00442">
        <property type="entry name" value="Helicase_Hel308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048772">
        <property type="entry name" value="Hel308-like_dom4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022965">
        <property type="entry name" value="Helicase_Hel308"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF10">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE HEL308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21280">
        <property type="entry name" value="Helicase_dom4_arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14520">
        <property type="entry name" value="HHH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 10 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 10 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="29"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="235"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIF84775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="712" mass="78007" checksum="20C7D32B18A00FCC" modified="2014-10-29" version="1">MQTIPDTIKAILGSLGYESLYPPQEKAMAAGILDGKNVLVTTPTASGKTLVAMMAIARTLQRSKKAVYLTPLRALASEKASDLKALEGIDLGLGRKAKVMVATGDYDSSGKELAFADVIVLTNEKMDTLFRHGVGWLGEVGLFVADEVHLIGDRERGPTLEMMLTRIRKLYSDAQIVALSATVSNADEISDWLSCTLVESCWRPTKLVEGVYEYGSVRMGDGRTFRVQTAGTSASVDLAIDALDNGGQALIFAETRKRASSLAAKAAEGVYKRLDKGARELAAKASAEILDKGDDAELTRTLAQLVGKGVAFHHAGLAPSSRKIVEESFKAGIVKLLTATPTLAAGVNLPARRVVVASILRYDAEYGGNVPISVMEYKQLCGRAGRPKYDTAGEAIIVAESTTATNGDEIYDHYVLGTPEPLRSQLAGDRAIRFHLLSTIASVPGMKKPEILEVFASTLFARQYRSATVQFKVESALEYLESEELVKARNERYIATEFGKRTSLLYIDPQTAVDFRDALNRAEKGRRKRTLGFLHLVTQSPDFYPKLSLRKKDPDEVSLLLQERRGELLYDISEYDCSRSFWALAEWMEEAGDRVLGDRMGVEPGDMHRMVETGEWLAYSLYEVAKLLGREDMLSDLYALRTRIRYGIKDELISLVALEGVGRVRARALYNAGLTDVPKVAKAPQAKLASIPKIGPAVAEKIKAQLARRQTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUB6</accession>
    <name>A0A075MUB6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Diaminopimelate decarboxylase</fullName>
            <ecNumber evidence="5">4.1.1.20</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_03207</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="4.1.1.20" evidence="5"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUB6"/>
    <dbReference type="STRING" id="1459636.NTE_03207"/>
    <dbReference type="KEGG" id="nev:NTE_03207"/>
    <dbReference type="eggNOG" id="arCOG02268">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026444_0_1_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008836">
        <property type="term" value="F:diaminopimelate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="entry name" value="Lyase, Ornithine Decarboxylase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43727">
        <property type="entry name" value="DIAMINOPIMELATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43727:SF2">
        <property type="entry name" value="GROUP IV DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="Alanine racemase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn/DAP/Arg decarboxylase 2 N-terminal" evidence="4">
        <location>
            <begin position="52"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="370"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600183-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF85236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="447" mass="49606" checksum="D2D64A5DCB47C118" modified="2014-10-29" version="1">MAENTQVQLVPKQTSALLNRFATPLDVKSLVAQYGTPLYLVDEDTLHAKARELQRAYSKFKGPVKVAYSIKANFSPAIVRAFMKDGLTFDLTSLGELHFIKQCNADPENVIYTSVTEEPEEYVEVLKSGVRRIVVSSHKGMMNLALAAGQVGVRPLTMIRVNPEVATDAKVRASYKNGKFGVPFNGGTIDSATKMVKYLMGSDLLKFEGFHFHLGSQITDFSCYTHALDKMDAFMTKMKKEYPNFQVNTFDIGGGTPVFYNDPVPTPAEMAQNHLARLNQLAETHGIFTLMIESGRFLVAESSILVSRIVNTKEYNEHKIVIVDAGYHILLDAALLKQEYPQEVIPVVDSQDRTTALATPKNTHLAGRLCDTYDVFPLSKASDMSGAEVGNYVSFYNVGAYSVVFNMPFHCQTKPPVVMKDSDGKYRLVRKGTTYEQLFVEEGGDIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUH1</accession>
    <name>A0A075MUH1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative signal-transduction protein containing cAMP-binding and CBS domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_03282</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUH1"/>
    <dbReference type="STRING" id="1459636.NTE_03282"/>
    <dbReference type="KEGG" id="nev:NTE_03282"/>
    <dbReference type="eggNOG" id="arCOG00606">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040681_7_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044065">
        <property type="entry name" value="ACP_MB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051257">
        <property type="entry name" value="Diverse_CBS-Domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43080:SF2">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43080">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN CBSX3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51901">
        <property type="entry name" value="ACP_MB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="26"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="90"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="ACP-type MB" evidence="4">
        <location>
            <begin position="163"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF85311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="202" mass="21947" checksum="5C06ECFDF6BA892F" modified="2014-10-29" version="1">MHVVKKPVRQHADPNMTTRVVVRDIMNSPVISASPKDTVRDVAKKMKSEKIGSIIIMDKDKPVGLVTDYDIVTQAVAKDAKPSSVTASDVMQDLHSIESEESITEAARLLRKHGIKRLGVVYKDRLVGIISASDVIAVTPDLVDVVSEKAGIIRGELGRPAGKVSGYCDECGEWSDLLQYDEEGTFICEVCRGEATTTPEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUI2</accession>
    <name>A0A075MUI2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome c biogenesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_03292</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701746.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUI2"/>
    <dbReference type="STRING" id="1459636.NTE_03292"/>
    <dbReference type="GeneID" id="41598946"/>
    <dbReference type="KEGG" id="nev:NTE_03292"/>
    <dbReference type="eggNOG" id="arCOG02398">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053225_2_0_2"/>
    <dbReference type="OrthoDB" id="115386at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051790">
        <property type="entry name" value="Cytochrome_c-biogenesis_DsbD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039447">
        <property type="entry name" value="UreH-like_TM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31272:SF9">
        <property type="entry name" value="BLL1027 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31272">
        <property type="entry name" value="CYTOCHROME C-TYPE BIOGENESIS PROTEIN HI_1454-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13386">
        <property type="entry name" value="DsbD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Urease accessory protein UreH-like transmembrane" evidence="2">
        <location>
            <begin position="61"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF85321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="263" mass="27667" checksum="2F7049660F83AD38" modified="2014-10-29" version="1">MVETSVLVSALAGAGSFFSPCILPILPAFISYLSGTTLSEVRNQNQGQQPAASGSSGSSSSVTLKRSTRLNIFLNTVYFVLGFSLVFAVLGVIFNSVLAGVGTGFQGTLQTAGGVVIIVFGAYLILSTRFARLNFEKRMTNLPRFKASYITSFVFGAAFASGWTPCVGPILGSTLALAATSPGAAYNSLLAYAIGLGVPFLITGAFFSQATGVIRRMVKHLKYFNPIMGGILIVLGILVFTNQLAVIANFPLADQIINLQRGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUN2</accession>
    <name>A0A075MUN2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Adenylate kinase</fullName>
            <shortName evidence="12">AK</shortName>
            <ecNumber evidence="4 12">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 12">ATP-AMP transphosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">adkA</name>
        <name evidence="13" type="ORF">NTE_02793</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the archaeal adenylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="4 12"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701341.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUN2"/>
    <dbReference type="STRING" id="1459636.NTE_02793"/>
    <dbReference type="GeneID" id="41598481"/>
    <dbReference type="KEGG" id="nev:NTE_02793"/>
    <dbReference type="eggNOG" id="arCOG01039">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119371_0_0_2"/>
    <dbReference type="OrthoDB" id="26198at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00234">
        <property type="entry name" value="Adenylate_kinase_AdkA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023477">
        <property type="entry name" value="Adenylate_kinase_AdkA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003122">
        <property type="entry name" value="PRK04040.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13207">
        <property type="entry name" value="AAA_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 12 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12 13" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="16"/>
            <end position="24"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIF84833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="206" mass="22604" checksum="66E893FA2DA42498" modified="2014-10-29" version="1">MAGNNNNHRKRAIIVGIPGVGKTTVITRAAELLSSSPEKRKATIVTYGTLMFEEAQKIGVKNRDEMRRLPVEQQKKLQEQAARRIAEMQDDVVIVDTHLFISTREGYYPGLPMRLVTIMNPTNLIMVAADPYEIAERRKNDPTRQRDEASPEAIKNDLDFSKMMLASCSILTGAPFAIVINGDGQVDDAAAGVAGILAEGGEPLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MV03</accession>
    <name>A0A075MV03_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 8">Isoleucine--tRNA ligase</fullName>
            <ecNumber evidence="1 8">6.1.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NTE_03025</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>tRNA(Ile) + L-isoleucine + ATP = L-isoleucyl-tRNA(Ile) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="1 8"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701529.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MV03"/>
    <dbReference type="STRING" id="1459636.NTE_03025"/>
    <dbReference type="GeneID" id="41598695"/>
    <dbReference type="KEGG" id="nev:NTE_03025"/>
    <dbReference type="eggNOG" id="arCOG00807">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001493_1_1_2"/>
    <dbReference type="OrthoDB" id="30823at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023586">
        <property type="entry name" value="Ile-tRNA-ligase_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780:SF1">
        <property type="entry name" value="ISOLEUCINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780">
        <property type="entry name" value="SOLEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19302">
        <property type="entry name" value="DUF5915"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 9 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="10">
        <location>
            <begin position="42"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="11">
        <location>
            <begin position="696"/>
            <end position="843"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="NCBIfam" id="TIGR00392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIF85060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="1078" mass="123081" checksum="9490908B67907942" modified="2014-10-29" version="1">MEFNSRFDAKAVENEVRTHLDSLDLRAMLENELAGKPLVGYIEGPPTMNGEPHAGHLRGRVIKDLWYRFNTLRKNKVIFRAGWDTQGLPVELAAEKELGLTGSKAENVSKVGVEKIVETCKKLIHTYNEKWRAMDALLGMSFNYEKAYWTYKDEYIEREWQFLKKAWETGVLKEWFRVVAYCPSCQTSLSNAEVNQGYETVEDPSFYYKVKLADEDAFLIVWTTMPFTIVTDEMVGTNPKADYSYVWVTKDTSEGGERWVVGSDRLAELMKELRIEDYKVEKTVKGSELDGRRYVHPLLDMIPGLDELARTGSIHFVVAEDFVDTATGSGLVHLSPANGEEDFEIATKRNVPIFVPIDDRVVFTEKAGAFGGMFVRDADMKVFEAMKAKGASVKMGKLKHQYPTCWRSHHKVVWLARREYFYILSNLGDRPLEAAQKVDYFFDQPKNRFVEIIREQHPWCISRERVWGTPLPIWACGKCGHKEPLFSRADIVKKAAELPDGAEFELHRPWIDRIKVKCEKCGAEMQREPFVLDTWHNSGAAPYASLTDEEYRDLIPAAFLTEGIDQTRGWAYTLLMENVIMQGAAPYRSFLFQGHVLDEKGNKMSKSLGNVIEARKLLSENPVDLIRLYFMWKSSPIEALNFSLDEMKTRTYQILSTLHNLHVYFRQNSEFDHFDREKHTVEWALENNLLAPTEVWLLSKMQGLIAEVTAAFERCRFHEGAKAIDEFIINHLSQTYVPLTRNVIWDDSAENLDKRLAVYATLGHVLLQIDIMLHPLSPFISDYMYLSCLVGRKKSVLLETWPVRDERLANTKVEGAFDMIKEVVSTANAARNLASLKRRWPIRDAIICGTHTELKPLEVEGVSESLKSQLNTEQYRMVQINAGSQLDKVSSLLENNLPITVSVSLVRKSVAPRVKADINSVLQAFEKIDKLALIRELKSSGKFVLAYNDGKTTEILPSDVDVAYKAQEGYSSSERANLVVFISTKRDKELIAKGLLRDLARNLQQLRKERQYNPTDILSAAYVAGLDDEEETAALSAMKDEMTYLVRVKAAVLSKEPLDKVSYKQVEIDGREFQISVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MV37</accession>
    <name>A0A075MV37_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative metal-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385114.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MV37"/>
    <dbReference type="STRING" id="1459636.NTE_01076"/>
    <dbReference type="GeneID" id="41596894"/>
    <dbReference type="KEGG" id="nev:NTE_01076"/>
    <dbReference type="eggNOG" id="arCOG02625">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065947_2_2_2"/>
    <dbReference type="OrthoDB" id="308128at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07344">
        <property type="entry name" value="M48_yhfN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.10">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053136">
        <property type="entry name" value="UTP_pyrophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002725">
        <property type="entry name" value="YgjP-like_metallopeptidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30399">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YGJP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30399:SF1">
        <property type="entry name" value="UTP PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01863">
        <property type="entry name" value="YgjP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YgjP-like metallopeptidase" evidence="1">
        <location>
            <begin position="32"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="235" mass="27110" checksum="654660B3914DECB0" modified="2014-10-29" version="1">MLSLPLDDGSVLCINVRTSSRARRLRLVSGIRGVEAVVPAAGYDEGKLQEFVQYKRDWIIKTANYYSKLREKTGHTESNVVYYLGKRYSVRLVKDRLVSAVVSDALGMATFHVTDMRRYKREIEQWYKEQTAKVIAEHLPPLSARLGLSYNKFTVKRQKSRWASCSKKRNLNFNLLLSAAPAEVIDYVIVHELCHIAEMNHSKRFWQLVEFADPGYRKHKEWLEDHAPVIGVQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MV71</accession>
    <name>A0A075MV71_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase</fullName>
            <ecNumber evidence="3">4.3.1.32</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NTE_02503</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + S-adenosyl-L-methionine = 7,8-didemethyl-8-hydroxy-5-deazariboflavin + 5'-deoxyadenosine + L-methionine + NH4(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:55204"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:59904"/>
            <dbReference type="ChEBI" id="CHEBI:85936"/>
            <dbReference type="EC" id="4.3.1.32"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; coenzyme F0 biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.32" evidence="3"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MV71"/>
    <dbReference type="STRING" id="1459636.NTE_02503"/>
    <dbReference type="KEGG" id="nev:NTE_02503"/>
    <dbReference type="eggNOG" id="arCOG00657">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054174_0_0_2"/>
    <dbReference type="OrthoDB" id="35347at2157"/>
    <dbReference type="UniPathway" id="UPA00072"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044689">
        <property type="term" value="F:7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01611">
        <property type="entry name" value="FO_synth_sub1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019939">
        <property type="entry name" value="CofG_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034405">
        <property type="entry name" value="F420"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03550">
        <property type="entry name" value="F420_cofG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004884">
        <property type="entry name" value="PRK06245.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43076:SF15">
        <property type="entry name" value="7,8-DIDEMETHYL-8-HYDROXY-5-DEAZARIBOFLAVIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43076">
        <property type="entry name" value="FO SYNTHASE (COFH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00294">
        <property type="entry name" value="7_8-didemethyl-8-hydroxy-5-dea"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01388">
        <property type="entry name" value="7_8-didemethyl-8-hydroxy-5-dea"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01064">
        <property type="entry name" value="F420__menaquinone_cofactor_bio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="11">
        <location>
            <begin position="52"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIF84552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="395" mass="43784" checksum="709767F31AE25989" modified="2014-10-29" version="1">MLADLETLLGLVERPGALTRPDAARLMAECSTEELVTAAGRVRDLTRPGGIITYSRKVFINLVNLCRDTCSYCTYKKEPGDPMLSMLNPEQVLAIAEAGRRARCTEALFVTGERPEQKYGEARSWLSSMGHSSTVDYIREMSELVLAKTGLLPHTNAGSLTKKEMAQLRDTNVSMGVMLETSSERLMSKGMAHEGAPSKNPRVRIKTLTSAGELRIPMTTGILVGIGETPEELVDSLFVIKELHEKHGHIQEVILQNFEPKPGTGMANFASTEKEYFLRAVAVCRLVMPFMNIQVPPNLNPAIYGRYVDAGINDWGGISPVTIDHVNPEFPWPTIDSVKQVTEEKGKRLRARLPVYPEYLLKKDGGFISERLEEYVRLLSDSSGLVKEEYVINGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MV74</accession>
    <name>A0A075MV74_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Asparagine synthase (Glutamine-hydrolyzing)</fullName>
            <ecNumber evidence="4">6.3.5.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_01106</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.3.5.4" evidence="4"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MV74"/>
    <dbReference type="STRING" id="1459636.NTE_01106"/>
    <dbReference type="KEGG" id="nev:NTE_01106"/>
    <dbReference type="eggNOG" id="arCOG00071">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG04741">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050152_0_0_2"/>
    <dbReference type="OrthoDB" id="8692at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050795">
        <property type="entry name" value="Asn_Synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11772">
        <property type="entry name" value="ASPARAGINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11772:SF46">
        <property type="entry name" value="ASPARAGINE SYNTHETASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asparagine synthetase" evidence="3">
        <location>
            <begin position="18"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Asparagine synthetase" evidence="3">
        <location>
            <begin position="168"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF83179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="320" mass="35863" checksum="357FED8BEBB60921" modified="2014-10-29" version="1">MDYYCDDLVQRLAKAVEKNRADALLLSGGLDSAIIASILKPRYCVTAALGKDAPDLAYARQVAQKYCRVHAEAVFGPEKMVELVDIVVQVFKTFDPIEVRNSCVALAALLRAKEDGYRAVVTGDGGDELFAGYNYLSRYYGDYEKLGQELARLWQVMHFSSRALGEKMGVEVRAPFLDREFAEYAKSMPAGEKVGERDGEKWGKFVLRKCFERDLGGLAWRKKMAQEQGAGTDQFHKYVEDMIDDSTYANRAKIALLEGVKLRSKEHLHYYAMFRSYNPPPKEEAGGCSRRCPECGGCFEWTGKFCRTCGAFPVTPVASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVC0</accession>
    <name>A0A075MVC0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Endonuclease related to archaeal Holliday junction resolvase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_02560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701146.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVC0"/>
    <dbReference type="GeneID" id="41598256"/>
    <dbReference type="KEGG" id="nev:NTE_02560"/>
    <dbReference type="eggNOG" id="arCOG05252">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1551749_0_0_2"/>
    <dbReference type="OrthoDB" id="29270at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019287">
        <property type="entry name" value="Hday_junct_resolvase-rel_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10107">
        <property type="entry name" value="Endonuc_Holl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Holliday junction resolvase-related" evidence="2">
        <location>
            <begin position="56"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="44"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF84607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="172" mass="20159" checksum="E67483ADC4686943" modified="2014-10-29" version="1">MANDILELFQSFRTILCLCPYCNQIQRLSDINPRYGGRIKKTWLDIYESRVKALEKKVEAFEEKAEELRQSATEKGRKQVPDILRRSMSIEFMNLSYNPYDIKALMHPVDFIIFDGLHSAENVKEIIFLSKKISNNGLNKIRESIRDAIRNGSYNWQVARVDLEGKITYHQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVG0</accession>
    <name>A0A075MVG0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Arabinose efflux permease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NTE_03191</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701656.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVG0"/>
    <dbReference type="STRING" id="1459636.NTE_03191"/>
    <dbReference type="GeneID" id="41598847"/>
    <dbReference type="KEGG" id="nev:NTE_03191"/>
    <dbReference type="eggNOG" id="arCOG00144">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_34_0_2"/>
    <dbReference type="OrthoDB" id="117970at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17504">
        <property type="entry name" value="MFS_MMR_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF9">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="241"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="270"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="436"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="484"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="34"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="513"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF85220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="561" mass="58930" checksum="E5357AA51902ED0F" modified="2014-10-29" version="1">MDISTSSNNNRVNTAKEEETAAVVVNDSRSAWFTLAILSSTLLAVMFSETMLLPAIPEIMQEFNIPYSTSAWIFSAYLIVAAVMTPIAGKLSDIYGKKKVLLILLAIYVAGITAGGFANNITFLLASRVIQGVGLAAVPAAFSLLRDSFPPSKLAIAVGVFGSAYSGGSVVGLLVGASIIQHFGWHTTFFSIAPVAAIVALMIAKFVKDNGSKEARLQLLSVKGTGHTTGAEKPTIDIKGALALSATISSFLLALTLIETGISPANLPQIVGALAASAASLAAFVFIEKRATAPLLDLRLLKHKILLPSYIILMATGITMFLVYPSIVQLVRSPQPFGFGGDAVDAANVQLPFMIMFLIFASATAFIINRIGNIRPTMLGAIISSVGAFGLLAFHSTGLMVSTNLAIIATGLSLTSTAGWNIIVSSSPKEFTGISVGVGALLFFVGMAIGPALAGLYMQSYHTSPSIGGAAGGPSYPAPESYNLVFATAGLFSITTLAFSILLRRKASLMSQQQQQNTAEEKIQQHPAEPNSNSSTEAGDKSLEEEEMSCINCTDSKKRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVJ0</accession>
    <name>A0A075MVJ0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03151</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701625.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVJ0"/>
    <dbReference type="STRING" id="1459636.NTE_03151"/>
    <dbReference type="GeneID" id="41598810"/>
    <dbReference type="KEGG" id="nev:NTE_03151"/>
    <dbReference type="HOGENOM" id="CLU_2784241_0_0_2"/>
    <dbReference type="OrthoDB" id="5693at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="71" mass="7821" checksum="FFCCF8F1FD684F52" modified="2014-10-29" version="1">MTAIMSLHNEAARSNFTTGQSWGALRKAWKGYRIAKVQGDASRMREYAGKIRKIQGELGVSVASFPHLGIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVL8</accession>
    <name>A0A075MVL8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PepSY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03176</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701644.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVL8"/>
    <dbReference type="STRING" id="1459636.NTE_03176"/>
    <dbReference type="GeneID" id="41598834"/>
    <dbReference type="KEGG" id="nev:NTE_03176"/>
    <dbReference type="HOGENOM" id="CLU_117489_0_0_2"/>
    <dbReference type="OrthoDB" id="12249at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="186" mass="19404" checksum="D6D76F7971E8BE49" modified="2014-10-29" version="1">MSATKNFLSKKVIVVSILAIGAVSAILVASSMIAQATAQQQQQQTMMWMRGAGQGTMMTTMPEIKGSVSVANETAGFISENLKVPFDAAAKTAQEQVANGTVLGGHVGVVQGYLVYTFFVVDTSNQTAGHLVIVDAGNGQALYTSEGHPLGSSFGPMSGHWGGGPGFGGWWGGPWKGHGFGWGMWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVQ4</accession>
    <name>A0A075MVQ4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03301</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVQ4"/>
    <dbReference type="KEGG" id="nev:NTE_03301"/>
    <dbReference type="eggNOG" id="arCOG07781">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_598002_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="457" mass="49782" checksum="74860C15AD08E893" modified="2014-10-29" version="1">MYTFFCGGKLVASLPGRLLPYYLRSRTLHEKIVRFLSIDGTKLAIFLVFSFIALMFFASIAAFLWPAVLVGGLYYFFLLEVFQVPSQLLGLDYHPPLADTTFLVTLATTVMEYFYLLASYITHVARRKMDLANMLMILSLVLVFISPFVILSYQPAPSTGAVVRYDIADGESCVGVPVSGAPMEWDQGRRTCHMRGSFIVGGGDEIRIAGDVTLEILSGGNLTTTRLISNNGTLVVNGGILKNNEGYIYNNGVIFHRNGTFVNSGIIENGRDFGGAVAAKNLPAPRIVNEATIENNYYIYNYANFTNRGLVDNKGQAQFFDESVAINAGTISNKGRINMAGEFDNEGGISNSGTIVIYRHFGPITGGVVTVLDNFGEIENTVGEIYNLGTINNHGRISNDVGRFVNRLDEDKAIINNEGVISNVAGEFLNDGIIANSCSGVIDGEIQNSLPADVCDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVV1</accession>
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            <fullName evidence="1">Cytidylate kinase</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">NTE_03352</name>
    </gene>
    <organism evidence="1 2">
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            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1459636.NTE_03352"/>
    <dbReference type="GeneID" id="41599000"/>
    <dbReference type="KEGG" id="nev:NTE_03352"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41930:SF1">
        <property type="entry name" value="DEPHOSPHO-COA KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41930">
        <property type="entry name" value="UPF0200 PROTEIN MJ1399"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13238">
        <property type="entry name" value="AAA_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="180" mass="19972" checksum="06F9278E1C29BDCD" modified="2014-10-29" version="1">MKPLILAFAGRIGSGKSTLSKEISEKMKWRRISFGDYVRSVASDRNLDHSRETLQQLGEALIVELGWKPFCKAVLDFGNWDPSEPLIVDGVRHLEALNAIKDIVYPARVALIFITLPEAERLERIERRDGVGRVGLTAVDSHSTESQVGFQLVELADLKVDGSTPVDKLVAQVTSFLQTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVX2</accession>
    <name>A0A075MVX2_9ARCH</name>
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            <fullName evidence="4">Large ribosomal subunit protein eL19</fullName>
        </recommendedName>
    </protein>
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        <name evidence="7" type="ORF">NTE_01387</name>
    </gene>
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            <taxon>Nitrososphaerales</taxon>
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            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1459636.NTE_01387"/>
    <dbReference type="GeneID" id="41597183"/>
    <dbReference type="KEGG" id="nev:NTE_01387"/>
    <dbReference type="eggNOG" id="arCOG04089">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083919_1_1_2"/>
    <dbReference type="OrthoDB" id="11624at2157"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0022625">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01475">
        <property type="entry name" value="Ribosomal_eL19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035970">
        <property type="entry name" value="60S_ribosomal_eL19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039547">
        <property type="entry name" value="Ribosomal_eL19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000196">
        <property type="entry name" value="Ribosomal_eL19_dom"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR057259">
        <property type="entry name" value="Ribosomal_L19e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057260">
        <property type="entry name" value="Ribosomal_L19e_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006343">
        <property type="entry name" value="PRK08570.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L19"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF01280">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25476">
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    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF48140">
        <property type="entry name" value="Ribosomal protein L19 (L19e)"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
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        <location>
            <begin position="4"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="57"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF83454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="149" mass="17290" checksum="8E79FE6CBB41AEDC" modified="2014-10-29" version="1">MVVNIRKKRELVARILGVGVNRVRFEPDKLEDVADSITRDNIRSLVKSGAIWTVKPKGTSRGRAEEKRSVWKKMHGKGQGSKKGKKTARIGKKEVYVVRVRSMRYHLRVMKERKDITNEIYWNLYKQVNGGHVRSLAHLRDLVKEAKTR</sequence>
</entry>
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    <accession>A0A075MW63</accession>
    <name>A0A075MW63_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02832</name>
    </gene>
    <organism evidence="2 3">
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            <taxon>Nitrososphaerota</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MW63"/>
    <dbReference type="STRING" id="1459636.NTE_02832"/>
    <dbReference type="KEGG" id="nev:NTE_02832"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="31" mass="3358" checksum="7AB80085463904F3" modified="2014-10-29" version="1">MKILDASEPGLGSAMTEDEAKNFQQVGDLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MW72</accession>
    <name>A0A075MW72_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01475</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
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            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
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    </dbReference>
    <dbReference type="RefSeq" id="WP_148700293.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="41597267"/>
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    <dbReference type="HOGENOM" id="CLU_2165351_0_0_2"/>
    <dbReference type="OrthoDB" id="6778at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="109" mass="12312" checksum="EC19C6661605EA4D" modified="2014-10-29" version="1">MQGNRVPRWLVESDPSWEKSIDSDLGMLKWTKKGTNIQAVCPPTSMFCDVLGQDDAQGGLVDLRAGIERMNRQQQANPAQGISKYLSSRYLNPGINGPARFDLRRMRKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWB4</accession>
    <name>A0A075MWB4_9ARCH</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">NTE_03512</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
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        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
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            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
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            <dbReference type="PubMed" id="24999826"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="KEGG" id="nev:NTE_03512"/>
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    <dbReference type="Proteomes" id="UP000028194">
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="176" mass="19460" checksum="FE082261C56B1540" modified="2014-10-29" version="1">MNTEDREVRRSTTVKASFLFLVSMDFNSIIKVCLVLDDRSISAKRSILGAFTEPAIGAEPTRFIHEILPIKAVPLKTLSLFYHYLDDFICHGGADRRPQFRRSLSLSARHCPVGAIRTISVLYSQKTPTILSSPIGTASEIDMMFPLRGSTTTLYSVALSISATVMVYTPLPCITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWE4</accession>
    <name>A0A075MWE4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWE4"/>
    <dbReference type="STRING" id="1459636.NTE_03425"/>
    <dbReference type="GeneID" id="41599067"/>
    <dbReference type="KEGG" id="nev:NTE_03425"/>
    <dbReference type="HOGENOM" id="CLU_1313078_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="209" mass="24272" checksum="1C68FFF12F7E22A3" modified="2014-10-29" version="1">MTYSSIMRSQYAQQHRNHRRKTPEYFFLSFFILKDMYLVKTRRKVIVTATLAAIATTALFLYYYFYVNYAQLTLRQIPPNQISTTMPFMEISQKTVDHTPVLARAIREVTIKYDRATQDCPARQLVLCDIPSATRYTTGMSIDEYEYLRDSGKISFKAAGGKDSSNNDAAVRETNIKYRCSHANLADATFEEYCYYTLKVERTPANWFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWN9</accession>
    <name>A0A075MWN9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03027</name>
    </gene>
    <organism evidence="1 2">
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        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
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            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWN9"/>
    <dbReference type="STRING" id="1459636.NTE_03027"/>
    <dbReference type="GeneID" id="41598697"/>
    <dbReference type="KEGG" id="nev:NTE_03027"/>
    <dbReference type="eggNOG" id="arCOG08805">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100103_1_0_2"/>
    <dbReference type="OrthoDB" id="9879at2157"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="177" mass="20304" checksum="867584DCBC713609" modified="2014-10-29" version="1">MKARQKTTIRTIRLQSNLDSVLQKDAEEKRTTVNSLISSIITRYAEWDRYADSFGFICLPRNGFKLILDALDDETVKKMAEEIGSRQPKELMMFVFKKTSLDAFISQFSLFSRYAGFGTYEIGSDGKNYTFVVHHELGRKWSLYLAHLGAQGLKSAINIMPRFHVTENSVVFEFSIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MX12</accession>
    <name>A0A075MX12_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative exosome subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01758</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MX12"/>
    <dbReference type="STRING" id="1459636.NTE_01758"/>
    <dbReference type="GeneID" id="41597528"/>
    <dbReference type="KEGG" id="nev:NTE_01758"/>
    <dbReference type="eggNOG" id="arCOG01042">
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR002739">
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    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_uL5_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38816:SF1">
        <property type="entry name" value="EXOSOME SUBUNIT"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR38816">
        <property type="entry name" value="EXOSOME SUBUNIT, DUF54 FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01877">
        <property type="entry name" value="RNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="RL5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="150" mass="16286" checksum="2876BF536A365AA0" modified="2014-10-29" version="1">MSEDTVVKFSSAEVQLVLHATEGHDKVLAAVEKALSVPAASFGGEQSEGHYGNAIMLLGAVVSSSKEAGALASRIISALNHTDRQELTDHIEEYSDEKGNLYLRLDKQRLCQGKVSLAESDAVRVKFKPVHRYKPSSSLQSYRGLLSSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MX78</accession>
    <name>A0A075MX78_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">NTE_03193</name>
    </gene>
    <organism evidence="1 2">
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701659.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MX78"/>
    <dbReference type="GeneID" id="41598850"/>
    <dbReference type="KEGG" id="nev:NTE_03193"/>
    <dbReference type="HOGENOM" id="CLU_2930033_0_0_2"/>
    <dbReference type="OrthoDB" id="378520at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="60" mass="6747" checksum="28B96BF71E2E6938" modified="2014-10-29" version="1">MSGKNASNIWKEAPMSRIDDRYNKLRRDIGNDFASNNGAAQVAELYSFHCGNCGYRISMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MXB4</accession>
    <name>A0A075MXB4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MXB4"/>
    <dbReference type="STRING" id="1459636.NTE_03233"/>
    <dbReference type="KEGG" id="nev:NTE_03233"/>
    <dbReference type="HOGENOM" id="CLU_2270920_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="102" mass="10912" checksum="75B429808D9E84FC" modified="2014-10-29" version="1">MCKRLLELYQRDKKKNLTMTATKLKGSNLLIMSGIVAILLATATAVIAPAMADNGNGEGGDNDIADCQHDKNTHKQEGTGSEGDAEFHIDQLLTEGETPICP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MXT3</accession>
    <name>A0A075MXT3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700742.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MXT3"/>
    <dbReference type="STRING" id="1459636.NTE_02047"/>
    <dbReference type="GeneID" id="41597786"/>
    <dbReference type="KEGG" id="nev:NTE_02047"/>
    <dbReference type="eggNOG" id="arCOG08683">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_147146_0_0_2"/>
    <dbReference type="OrthoDB" id="11172at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="148" mass="15150" checksum="85596AE140353669" modified="2014-10-29" version="1">MKLETWISVGSIALSAMFVALILSFYNFLISQGENPSRIIDPAGLLVQEVAISAAPGIVLAGVVFVMSRTTGNKPAGLLLVASGAIMTAGMVAALGMLPQIHPQYVQGGVGIVPYVFAAAGAGVAGLGGYLAVTSKRSRYAGNLDDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MYP4</accession>
    <name>A0A075MYP4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02331</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700965.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MYP4"/>
    <dbReference type="STRING" id="1459636.NTE_02331"/>
    <dbReference type="GeneID" id="41598047"/>
    <dbReference type="KEGG" id="nev:NTE_02331"/>
    <dbReference type="HOGENOM" id="CLU_2271130_0_0_2"/>
    <dbReference type="OrthoDB" id="375305at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="103" mass="11330" checksum="99F7F8A6923B34C8" modified="2014-10-29" version="1">MNPQAVLLKCAWEALSTLGEPTMQSIVWHLSNAGVEMVPETFDIRKFYPALADMIGDSGADIIMEIAARSMVLELQLDVPTDPRDPALEKVLKVLEVAQKVAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MYS7</accession>
    <name>A0A075MYS7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02367</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MYS7"/>
    <dbReference type="KEGG" id="nev:NTE_02367"/>
    <dbReference type="HOGENOM" id="CLU_2177772_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="109" mass="12130" checksum="437DFE65A8078E0D" modified="2014-10-29" version="1">MVRSSVVEFAGDMCSHFLPAFNAVVQVVILKDLCLFVAHAASLVIFHEKSLAVWLLQCLHVKTKTYAYYKIPAKEERRAIAKSPMNTIAARPASMYTRNGMPGMTQTPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MYW7</accession>
    <name>A0A075MYW7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Glycosyl transferase</fullName>
            <ecNumber evidence="10">2.4.1.212</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NTE_02402</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NodC/HAS family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.212" evidence="10"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701026.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MYW7"/>
    <dbReference type="STRING" id="1459636.NTE_02402"/>
    <dbReference type="GeneID" id="41598113"/>
    <dbReference type="KEGG" id="nev:NTE_02402"/>
    <dbReference type="eggNOG" id="arCOG01389">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029695_1_0_2"/>
    <dbReference type="OrthoDB" id="43988at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050501">
        <property type="term" value="F:hyaluronan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085029">
        <property type="term" value="P:extracellular matrix assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030213">
        <property type="term" value="P:hyaluronan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06423">
        <property type="entry name" value="CESA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22913">
        <property type="entry name" value="HYALURONAN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22913:SF12">
        <property type="entry name" value="MANNURONAN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="371"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="400"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="433"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="9">
        <location>
            <begin position="107"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIF84454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="464" mass="52459" checksum="2A7841B69AA76E90" modified="2014-10-29" version="1">MELVTRENYTPQKLTPRKKAVRSLIIAGAGALIATKLYMLFFYLDPILGIYSFLTTFLVFSSFIVSYTMYRDPVYGKKKGKKEEDGKNVNGDGGAGAPFSAQEPLVSVIIPAKNDPVMIIEAAKSCLASTYQNIEVIMVNDGSTDDTGHAMDLLRKEFPDRISVIHLAQNVGKRKAVREGIVSGPAKGDIILLIDSDCIIEKTAIERMVKVFDDPDVGAVSGHGRAVNAEQNTLTKMQDTWYDGQFSIMKAMESAFGTVTCCPGILSAYRKEAIMPALDKWANDVFLGADFTLGDDRHLTSYVIGGNKHYLDKEQKVWKAMYSESAIVYTEVPHRFKKFMWQQIRWKKSWLRVFFFTAPYYYKDRNPFAAAVYYLQMIWSFLSPVVAIRSLILLPLQGEYWSAVVYVAGLLFIGLLFAAEFKLRNPDTGGKWAYRLTWSVMGFFLSSLEYYSFLTVRNKSWLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MZ78</accession>
    <name>A0A075MZ78_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701108.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MZ78"/>
    <dbReference type="STRING" id="1459636.NTE_02505"/>
    <dbReference type="GeneID" id="41598209"/>
    <dbReference type="KEGG" id="nev:NTE_02505"/>
    <dbReference type="eggNOG" id="arCOG01055">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_159725_0_1_2"/>
    <dbReference type="OrthoDB" id="140255at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038723">
        <property type="entry name" value="ArnR1-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14947">
        <property type="entry name" value="HTH_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ArnR1-like winged helix-turn-helix" evidence="1">
        <location>
            <begin position="10"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="102" mass="11910" checksum="0D0EA21D9608CDFF" modified="2014-10-29" version="1">MSIPERKNNRGRIQIMGDVLGLATSGIRKTHIMYRANLSYEQVHMYLSELIERGLLVQHATDEGVVYRTTERGREFLYFYNKIVDFLEIPQQAGLEMPYLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MZF8</accession>
    <name>A0A075MZF8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Enolase</fullName>
            <ecNumber evidence="6">4.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">2-phospho-D-glycerate hydro-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">2-phosphoglycerate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">eno</name>
        <name evidence="12" type="ORF">NTE_02591</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible conversion of 2-phosphoglycerate (2-PG) into phosphoenolpyruvate (PEP). It is essential for the degradation of carbohydrates via glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(2R)-2-phosphoglycerate = phosphoenolpyruvate + H2O</text>
            <dbReference type="Rhea" id="RHEA:10164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.2.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds a second Mg(2+) ion via substrate during catalysis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Mg(2+) is required for catalysis and for stabilizing the dimer.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cell surface</location>
        </subcellularLocation>
        <text evidence="6">Fractions of enolase are present in both the cytoplasm and on the cell surface.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the enolase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="6"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701170.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MZF8"/>
    <dbReference type="STRING" id="1459636.NTE_02591"/>
    <dbReference type="GeneID" id="41598285"/>
    <dbReference type="KEGG" id="nev:NTE_02591"/>
    <dbReference type="eggNOG" id="arCOG01169">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031223_0_1_2"/>
    <dbReference type="OrthoDB" id="8680at2157"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00318">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020810">
        <property type="entry name" value="Enolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020811">
        <property type="entry name" value="Enolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902:SF1">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00113">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03952">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001400">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00148">
        <property type="entry name" value="ENOLASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01192">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01193">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 6 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 6 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Enolase N-terminal" evidence="11">
        <location>
            <begin position="7"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Enolase C-terminal TIM barrel" evidence="10">
        <location>
            <begin position="133"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6 7">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6 7">
        <location>
            <position position="334"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>(2R)-2-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 9">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 9">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 9">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>(2R)-2-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="361"/>
            <end position="364"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="363"/>
        </location>
        <ligand>
            <name>(2R)-2-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>(2R)-2-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="385"/>
        </location>
        <ligand>
            <name>(2R)-2-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="385"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIF84634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="415" mass="44679" checksum="7EFCE99524105B98" modified="2014-10-29" version="1">MPSSPSITALDARIVFNSRGSKTIEVDVVTDKEFSGRACAPSGASVGKLEAQSFPDNKPEKALAAFNANKKKFIGLDASDTKAVFDALRSIDNTDNYSKIGGSVAYALSIAAVDSAAKAKGVPLFQLLNPQKPYRFPFPLGNVLGGGAHAGPGTPDIQEILACPVGAKGIMEALEMNFRFHSEMRKVIESMDSRFTYGRGDEGAWAPNVNNDQALEIAEKTIERCGYSLGKDMALGIDFASSSFWDEENSVYDYARQGIKRDTGEQIEFAGRLIKDFKLAYAEDAVHEADFQSMAVLTKKYPRTLVTGDDMLVTNASMVKKAVEFGACSGAILKVNQAGSLYDALQFARECTKNGIGIITSHRSGESVDSHIAHIAVATGSKMIKTGVLGGERIAKLNELVRLSEYDLIADMQDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MZN7</accession>
    <name>A0A075MZN7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Selenophosphate synthase</fullName>
            <ecNumber evidence="1">2.7.9.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02661</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.9.3" evidence="1"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701228.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MZN7"/>
    <dbReference type="STRING" id="1459636.NTE_02661"/>
    <dbReference type="GeneID" id="41598353"/>
    <dbReference type="KEGG" id="nev:NTE_02661"/>
    <dbReference type="eggNOG" id="arCOG00643">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_583458_0_0_2"/>
    <dbReference type="OrthoDB" id="6643at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004756">
        <property type="term" value="F:selenide, water dikinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF038049">
        <property type="entry name" value="SelD_rel_HyperS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="465" mass="51043" checksum="6D8FD6C0B3809E6D" modified="2014-10-29" version="1">MSNNFWENVEQYRKLGADPLRWLSSCSLEADSNIVKSALAEIKRSTIKLASPFWFDSYFHIEGKEPELTRRVYDLASPVVDKEVEVKRALAILRVHSATAESPQALAETLGKFFSVFRAKVAVTSAPVATTEHPGAQFALLDYIELRRGNKDGYMPALSSFEQVADITKAPDDEVHVRIALTDAVERLNLLGCGNSALFKFFPIYDAPDEGMLDRIRTNLDAFMSRYNLVMEDYSSLKRGRLFYGTSAVAITNKELPTRYEQIEEGMEVMITNKFGGLAAVSLHALALSDPANALKFEQAGVSMPDLTAARDEALKSLSEPHFALGKIISKYCPDFGQGYDKSAHITAVYPVGAKGLFALGALAELANAHIAVNELPVRHEEVARLATKESLVENSTASQHGCHILVGTKDVLNLAAEDLRQHHFAPERIGFVAKKGAPSIAIEKDASMYVAQKAKLARLLKPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N025</accession>
    <name>A0A075N025_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ornithine cyclodeaminase</fullName>
            <ecNumber evidence="8">4.3.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Archaeal ornithine cyclodeaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">NTE_02809</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the conversion of ornithine to proline, with the release of ammonia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-ornithine = L-proline + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:24368"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="4.3.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the AgrE/ArgZ ornithine cyclodeaminase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.12" evidence="8"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701355.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N025"/>
    <dbReference type="STRING" id="1459636.NTE_02809"/>
    <dbReference type="GeneID" id="41598496"/>
    <dbReference type="KEGG" id="nev:NTE_02809"/>
    <dbReference type="eggNOG" id="arCOG04422">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056125_0_0_2"/>
    <dbReference type="OrthoDB" id="64170at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008473">
        <property type="term" value="F:ornithine cyclodeaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd12144">
        <property type="entry name" value="SDH_N_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2690">
        <property type="entry name" value="LOR/SDH bifunctional enzyme, conserved domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10690">
        <property type="entry name" value="putative lor/sdh protein like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005239">
        <property type="entry name" value="ArgZ/ArgE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048964">
        <property type="entry name" value="ArgZ/ArgE-like_C_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048963">
        <property type="entry name" value="ArgZ/ArgE-like_C_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007545">
        <property type="entry name" value="LOR/SDH_bifunc_enz_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043009">
        <property type="entry name" value="LOR/SDH_bifunc_enz_cons_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00300">
        <property type="entry name" value="TIGR00300 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21571">
        <property type="entry name" value="ArgZ-like_C_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21570">
        <property type="entry name" value="ArgZ-like_C_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04455">
        <property type="entry name" value="Saccharop_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LOR/SDH bifunctional enzyme conserved" evidence="11">
        <location>
            <begin position="8"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Arginine dihydrolase ArgZ/ArgE-like C-terminal first subdomain" evidence="13">
        <location>
            <begin position="107"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Arginine dihydrolase ArgZ/ArgE-like C-terminal second subdomain" evidence="12">
        <location>
            <begin position="192"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00052109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00056756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00061348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00066346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00081581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF21570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF21571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AIF84849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="415" mass="45629" checksum="962F710C0A3E2F6E" modified="2014-10-29" version="1">MAAGKHEQEIEVKGHLIDSMILTRIFDHVMDLKGDFQVLEFTVGKKKKDPSYARLLVRGKDEEHLERILEAVYREGAQPVSVQEARLVPASADCVMPDDFYSTTNNPTQVFHSGRWIDVQNMMMDKCIVVDVKSMTAECKMIRDLKKGDMIVVGERGVKITPQERPREGVDIFQFMSSSSSSERPTQHIARKVADDIYNTKKEGGKIIVVSGPVLVHSGASEALARLIRMGYIDGLLAGNAIAVHDVENALLGTSLGMHVKDGTLAVRGHRNHMQAINEVFKAGGLKAMVEKKILKSGVMYECIKHDVPFVLAGSIRDDGPIPDVVTDVVEAQRRYKKVLKGAKMVLMFSTMLHSIAVGNMLPSSVKVVAVDISQPVVTKLVDRGTAQAVGIVTDVGAFLPIVADHLEEKVARRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N0U5</accession>
    <name>A0A075N0U5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5679 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987284.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N0U5"/>
    <dbReference type="STRING" id="1459636.NTE_03059"/>
    <dbReference type="GeneID" id="68225782"/>
    <dbReference type="KEGG" id="nev:NTE_03059"/>
    <dbReference type="eggNOG" id="arCOG07442">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_200516_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044044">
        <property type="entry name" value="DUF5679"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18930">
        <property type="entry name" value="DUF5679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5679" evidence="1">
        <location>
            <begin position="4"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="45" mass="4979" checksum="237B83EEF47EC1DF" modified="2014-10-29" version="1">MEAYCVKCKAKREMKDPKKITMKNGKPATQGICPKCGTKMFKIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N0X7</accession>
    <name>A0A075N0X7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Citrate lyase beta subunit</fullName>
            <ecNumber evidence="5">4.1.3.34</ecNumber>
            <ecNumber evidence="5">4.1.3.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_03105</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="4.1.3.34" evidence="5"/>
    <dbReference type="EC" id="4.1.3.6" evidence="5"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701587.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N0X7"/>
    <dbReference type="STRING" id="1459636.NTE_03105"/>
    <dbReference type="GeneID" id="41598765"/>
    <dbReference type="KEGG" id="nev:NTE_03105"/>
    <dbReference type="eggNOG" id="arCOG00760">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044864_0_0_2"/>
    <dbReference type="OrthoDB" id="9170at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008816">
        <property type="term" value="F:citryl-CoA lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011206">
        <property type="entry name" value="Citrate_lyase_beta/mcl1/mcl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32308:SF0">
        <property type="entry name" value="HPCH_HPAI ALDOLASE_CITRATE LYASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32308">
        <property type="entry name" value="LYASE BETA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G13030)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015582">
        <property type="entry name" value="Cit_lyase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH/HpaI aldolase/citrate lyase" evidence="4">
        <location>
            <begin position="4"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF85139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="287" mass="30980" checksum="B4965B7074FAF4D0" modified="2014-10-29" version="1">MMFRTLIFVPGANARFVEKAKTLAADIVCFDLEDSVPANEKEAARKVIAGALAKRQEYQKPVYVRTNSPESGLIDADIKAVLQKGIDGLVIPKVNDANEVAEIVRAVSALEKERGTGRVALIPSIETARGVVNTYAISSADDRVSAVVFGVFDFLHDMRMDYDERDGSGYAYARAKIPVDARAAGVAAIDAIWQKVDDVEGLTQDAAVAKRLGYSGKSIIHPGQIEPVHKVFLPSKSEVEWAKKVVAALGEAMEKGTGRLAVRLEGRMIDAVHYKQAKSILEAAGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N1U1</accession>
    <name>A0A075N1U1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701837.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N1U1"/>
    <dbReference type="STRING" id="1459636.NTE_03396"/>
    <dbReference type="GeneID" id="41599042"/>
    <dbReference type="KEGG" id="nev:NTE_03396"/>
    <dbReference type="HOGENOM" id="CLU_1032901_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="269" mass="29438" checksum="E68371E84B569E6C" modified="2014-10-29" version="1">MSSNSEAPATADKPSETQRILKELAAAIDSGSDLTNKETRVRVCHDIEARLQVPYGNVTKQVNRALREAAQKAGAPPASVKRNLGGSTTEVKIPPLAQAEQAATSTEPAARSTEPAAPGQQASQPQRPENAILAKYNNLEELMAGPEYQRLYLTFYSAFSEVHGMYARIGIPPFEEEIEFTVVGSDGTTRKQKMLRTQHLAQQWALAMIKFGWDFPPWLEKGMLIGGTLLTLAMPPLAHFGLLDDIKSGFGRKNKKDAKPEPEKSENPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N251</accession>
    <name>A0A075N251_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase propeptide domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N251"/>
    <dbReference type="KEGG" id="nev:NTE_03496"/>
    <dbReference type="HOGENOM" id="CLU_102442_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025711">
        <property type="entry name" value="PepSY"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03413">
        <property type="entry name" value="PepSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PepSY" evidence="1">
        <location>
            <begin position="90"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="247" mass="25188" checksum="2D308C9BF5CF6738" modified="2014-10-29" version="1">MRSRAAVAIIIGLVIAALPSVGMGMTTSTATTVTPLSAFAQAGPITSDNNNTTNSNTSNVTTAMPQLNGSINVKQAAKDFLNQHINATLVDATDLAEEQVTNGTVVAGSLDAVQDSLVYNITVADLNSELAYKVYVDPSTGRVLARSTEGRPLVELGAAAGNVTTFGNLTITLVDAANLAENQIPNGIAIAGEIEGSEGGNVGVVYSITVADVNGGTLYKMTVDPNTSAVSTPQMMPMGNLAIGGVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLD7</accession>
    <name>A0A075MLD7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aspartate carbamoyltransferase</fullName>
            <ecNumber evidence="7">2.1.3.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Aspartate transcarbamylase</fullName>
            <shortName evidence="7">ATCase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pyrB</name>
        <name evidence="11" type="ORF">NTE_00009</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">Catalyzes the condensation of carbamoyl phosphate and aspartate to form carbamoyl aspartate and inorganic phosphate, the committed step in the de novo pyrimidine nucleotide biosynthesis pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>carbamoyl phosphate + L-aspartate = N-carbamoyl-L-aspartate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20013"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterooligomer of catalytic and regulatory chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.2" evidence="7"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699164.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLD7"/>
    <dbReference type="STRING" id="1459636.NTE_00009"/>
    <dbReference type="GeneID" id="41595963"/>
    <dbReference type="KEGG" id="nev:NTE_00009"/>
    <dbReference type="eggNOG" id="arCOG00911">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043846_1_2_2"/>
    <dbReference type="OrthoDB" id="7792at2157"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00116"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004070">
        <property type="term" value="F:aspartate carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1370:FF:000021">
        <property type="entry name" value="Aspartate carbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="entry name" value="Aspartate/ornithine carbamoyltransferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00001">
        <property type="entry name" value="Asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002082">
        <property type="entry name" value="Asp_carbamoyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00670">
        <property type="entry name" value="asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002032">
        <property type="entry name" value="PRK00856.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45753:SF6">
        <property type="entry name" value="ASPARTATE CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45753">
        <property type="entry name" value="ORNITHINE CARBAMOYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00101">
        <property type="entry name" value="ATCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="Aspartate/ornithine carbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aspartate/ornithine carbamoyltransferase carbamoyl-P binding" evidence="10">
        <location>
            <begin position="9"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Aspartate/ornithine carbamoyltransferase Asp/Orn-binding" evidence="9">
        <location>
            <begin position="156"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00043884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIF82093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="312" mass="34880" checksum="DE41908159976CC5" modified="2014-10-29" version="1">MPNNHFYDRDIVSIKDFSKADLEYVFSATDKIRTMKPGERGELGRGRTLGYIFYEPSTRTRMSFEAAMASLGGSFIGISELKSSSVEKGESLADTIRVIDLYSDVIVLRHPMDGSSRFAAELSQNPIINAGSGSEEHPTQALLDLYTIMKEKGRIDGLSIAIVGDLKYGRTVYSLLYGLANYRVDVHLVSPPSLAVRKESIYDVQGKLKIKEHHELDDVLAHADVLYVTRIQRERFPDVQEYEKVKGSYTVDSATLEKAKQDVAVMHPLPRLDEISHSIDHTKNAVYFRQAANGKELRAALLALMLNESPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLX4</accession>
    <name>A0A075MLX4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Probable thymidylate kinase</fullName>
            <ecNumber evidence="7">2.7.4.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">dTMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tmk</name>
        <name evidence="9" type="ORF">NTE_00051</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>dTMP + ATP = dTDP + ADP</text>
            <dbReference type="Rhea" id="RHEA:13517"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58369"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the thymidylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.9" evidence="7"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987079.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLX4"/>
    <dbReference type="STRING" id="1459636.NTE_00051"/>
    <dbReference type="GeneID" id="41596002"/>
    <dbReference type="KEGG" id="nev:NTE_00051"/>
    <dbReference type="eggNOG" id="arCOG01891">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049131_1_1_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004798">
        <property type="term" value="F:dTMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006233">
        <property type="term" value="P:dTDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006227">
        <property type="term" value="P:dUDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01672">
        <property type="entry name" value="TMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00165">
        <property type="entry name" value="Thymidylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039430">
        <property type="entry name" value="Thymidylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018094">
        <property type="entry name" value="Thymidylate_kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00041">
        <property type="entry name" value="DTMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10344">
        <property type="entry name" value="THYMIDYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10344:SF1">
        <property type="entry name" value="THYMIDYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02223">
        <property type="entry name" value="Thymidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate kinase-like" evidence="8">
        <location>
            <begin position="24"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="26"/>
            <end position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF82135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="245" mass="28799" checksum="81CC9736D6162E1C" modified="2014-10-29" version="1">MTMMMMSSVNNKNREIIPGRLIIVEGVDGSGKSTQIRLLEKWFRYMGLQVFFTEWNSSETVKEITSKGKKKALLTPITFSLLHATDFADRYERHILPLLRAGYIVLADRYIYTAFARDVVRGCHPRWVRHMYDFAVKPDISFYFRVPVDIAFDRIVKNRPKLKYYEAGMDLNLSNDPYESYRIFQGRIVEQYDSMVGPENFVVIDGTADIEEQQKVMRQKVMELLPRQFFRGKQQQQEEKEVPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLX9</accession>
    <name>A0A075MLX9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00161</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLX9"/>
    <dbReference type="KEGG" id="nev:NTE_00161"/>
    <dbReference type="HOGENOM" id="CLU_200166_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="60" mass="6753" checksum="0826F71F41CFBACD" modified="2014-10-29" version="1">MQKPFQIKPLKAEPGRGLPYCNACGAYATNEAHFDVGNYIVLRRYCDKCLPTAEYDPSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMH1</accession>
    <name>A0A075MMH1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00366</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158384958.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMH1"/>
    <dbReference type="GeneID" id="43502555"/>
    <dbReference type="KEGG" id="nev:NTE_00366"/>
    <dbReference type="HOGENOM" id="CLU_2968266_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="58" mass="6519" checksum="DA8E1B1617FF574D" modified="2014-10-29" version="1">MKIDVEVVVKSDLTCDMAYERLRSLGVNVPAVIEANLTDEELALLTHKIMELMEKDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMH7</accession>
    <name>A0A075MMH7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00371</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMH7"/>
    <dbReference type="KEGG" id="nev:NTE_00371"/>
    <dbReference type="HOGENOM" id="CLU_3038861_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="54" mass="6264" checksum="BD8B389F931A4F93" modified="2014-10-29" version="1">MTMITRLDAHFIPQGLAMMQTGIYLYFLLLLRMACRVRAIIVPACFFGKHFLTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MN16</accession>
    <name>A0A075MN16_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00458</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699491.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MN16"/>
    <dbReference type="GeneID" id="41596334"/>
    <dbReference type="KEGG" id="nev:NTE_00458"/>
    <dbReference type="HOGENOM" id="CLU_1113907_0_0_2"/>
    <dbReference type="OrthoDB" id="379126at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="257" mass="26323" checksum="DD736AEF2F277BB8" modified="2014-10-29" version="1">MSFFNKKKSVRGSNGSGGFSPRNAAMLILVVAAFSLVIAPAVSSSMARPAAAASAEPTFRTQQAPIATDAVGNLSGNEGAADSGNNTGGGGNENGNAQCPPGFQCLIRGDVGATKQFALDISATGKVSGSNALATAKIEAIVDIDTKKGSILRVQENSVSGSAEIKDRNGNTAATLDLSNITFDVKGAKLTVNADFTDQDDDKGKFTASLFAKDKIDANSSTVTLNSKSNSLSINYNTVNQRFTATGNSVEAELSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNI1</accession>
    <name>A0A075MNI1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type I restriction-modification system methyltransferase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_00285</name>
        <name evidence="4" type="ORF">NTE_01143</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699365.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNI1"/>
    <dbReference type="STRING" id="1459636.NTE_00285"/>
    <dbReference type="REBASE" id="90018">
        <property type="entry name" value="M.NevSR1ORF1143P"/>
    </dbReference>
    <dbReference type="REBASE" id="90020">
        <property type="entry name" value="M.NevSR1ORF285P"/>
    </dbReference>
    <dbReference type="GeneID" id="41596956"/>
    <dbReference type="KEGG" id="nev:NTE_00285"/>
    <dbReference type="KEGG" id="nev:NTE_01143"/>
    <dbReference type="eggNOG" id="arCOG02632">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008343_0_2_2"/>
    <dbReference type="OrthoDB" id="45790at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003356">
        <property type="entry name" value="DNA_methylase_A-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029464">
        <property type="entry name" value="HSDR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052916">
        <property type="entry name" value="Type-I_RE_MTase_Subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42998:SF1">
        <property type="entry name" value="TYPE I RESTRICTION ENZYME HINDI METHYLASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42998">
        <property type="entry name" value="TYPE I RESTRICTION ENZYME HINDVIIP M PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13588">
        <property type="entry name" value="HSDR_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02384">
        <property type="entry name" value="N6_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00507">
        <property type="entry name" value="N12N6MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Type I restriction enzyme R protein N-terminal" evidence="2">
        <location>
            <begin position="31"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="DNA methylase adenine-specific" evidence="1">
        <location>
            <begin position="284"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF82367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF83216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="656" mass="75294" checksum="06F5552EBB2B0BDD" modified="2014-10-29" version="1">MDRFVDGNSVSYVPPGKLQSYLTQELIKETPEEHVRQRVIRSLVEEYGYDLSQIRVNFKLAVGGKRLPVDIAVFHDGKPPLQENIYIIVETKRPEIKSTDKESGIDQLGSYVSSAMNCEFALWTNGLEKLCFQKIESKTKGQKYEPKPVIDIPIHGKTIEEYEKPDFTQLRPATELKSVFKRINDYIYGRQGMREDQAFHELLKLIFCKVYDERSDEIHFYVTNKEIGSDMGAMSVKKRIDELFDSVRKQYQYIFKNDPKILLNPRVLAYVVGQLQNYYLLRTDADVKGDAYEELVGKNLRGSLGEYFTPRNICRLAVRILLAMHTKQQIQDAKIIDPACGTGGFLISVIDTMRQYYYDREIAKDPSHERAMQIVDDEIRMYCARCLYGIDFNEVLVQAAQMNEVIHGNGSSNLFSVDSLKAPGEWPIDVAEKVKLGSFDMLMTNPPFGENIIIDDRHLLSQYDLAHVWKENDDGILERTDDIKSRMPPQLLFIERSVQLLKPNGKLAIVLPDSVLSNPGLKYVRHWILTHTKVIASIDLAKEAFEPSTGTKTSLLILERKNETEMALEKKGGKLPDYDVFMAIAGKVGKNSRGDSIFKRTPEGEMIEIEKETYIVKIVDRSKVREKLVTKEPILDDDLPHIGDEFVEWWNRKGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNI4</accession>
    <name>A0A075MNI4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01043</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNI4"/>
    <dbReference type="STRING" id="1459636.NTE_01043"/>
    <dbReference type="KEGG" id="nev:NTE_01043"/>
    <dbReference type="HOGENOM" id="CLU_119362_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="197" mass="22413" checksum="512E9310E6D6F4F8" modified="2014-10-29" version="1">MCILNYQTTVHYFINYLLAHFPQDSDNNNKTQITFSWLEQSGMGRKKNKTAVISGTSNIARTIADFQSNIRKDWCACVDSSIPAFSMSDGIRQGYVLAKKRGVRIRYVTEITAENLEYCKELMTFVELRHFAGVRGSFAVSETEFVAGIRGNNKKKTPLAKLVYSNVKEVVAHQRDAFETLWENATPAVRRIKELES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNK5</accession>
    <name>A0A075MNK5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative xylanase/chitin deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNK5"/>
    <dbReference type="STRING" id="1459636.NTE_00310"/>
    <dbReference type="KEGG" id="nev:NTE_00310"/>
    <dbReference type="eggNOG" id="arCOG02508">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG02876">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019209_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059177">
        <property type="entry name" value="GH29D-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050248">
        <property type="entry name" value="Polysacc_deacetylase_ArnD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13290">
        <property type="entry name" value="CHB_HEX_C_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0858">Xylan degradation</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="49"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="798" mass="85747" checksum="3781D307D58CD2D3" modified="2014-10-29" version="1">MMRLSSKPSRHGAPAFVLAVMLLASSTTLFLGSSDYYYHPKQAYAAPCNCVIFRIDDIQDSWINNVQVAVMDKFIAHSQKATLAEIMNFFGSDSLVLDKTKQGGNAGLFEYALHGWNHDDYTTLSQSQQQSDLQKANDKMQSLYGKKTNIFITPYNVFNANTLTAMKNLNLKIISADTFASYYDSHPSTPFVTSPDSNGIYHAPEITAFSVWTNDQNIQQSASKILSDIDSSISQRGWVVVTMHPQDFANFSSSGEALNSVNQNSIARIDTVLNGINSRGYSIKSFNELVGLAQGGGGDTTPPVVTATPPGGSYSSAQSVTLSANEPVTIYYTTNDSTPTTSSPVYSSPISITSTTTLKFFAVDTAGNASPIKSETYTISGSSFPITHMSDTTKTFGLAMYAGTQQAYAEFVTPGSQLAGKSIDQMTIELRKTGSPTGTVQVGVFNSDSTVKKLFGTKDASTLTSTYMDYTFSLASNDLYTIQSGDRIGVKYSGGNSANFVAVMLDKDAADPFDGANSHLQQYDGTSWLDFTADDLYMILKQTHGATDTTPPTVTAMPAGGTYLTTVSVTLAANEPATTYYTLDGSTPTTSSNVYTTSIQISTTTTLKFFARDTAGNASPVKSETYTINSSPSFPVTHMSDTTQTFGLATNAAAMPSHVEFASSTSQLVGKSIDQITLKMRKTGSPTGTVQVGVFNSDLSVKKLFGTRDAATGITSTYTDYVFSLTNNELYTIQPGDRIGIKYAGGDASNFVAVMLDKDAADPFDGANTYRQQFSTSTNSWTSLTPDDMYMILVQTHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNP1</accession>
    <name>A0A075MNP1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNP1"/>
    <dbReference type="KEGG" id="nev:NTE_00345"/>
    <dbReference type="HOGENOM" id="CLU_2783846_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="68" mass="7835" checksum="A4B8897B669A35D2" modified="2014-10-29" version="1">MHIDEDICTHMPAPSQARVHTHVHLSGSDMMVLYSSNSRTRVFVCMIFSFTYKKDIEQSEGAPLRCQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNV0</accession>
    <name>A0A075MNV0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNV0"/>
    <dbReference type="STRING" id="1459636.NTE_00815"/>
    <dbReference type="KEGG" id="nev:NTE_00815"/>
    <dbReference type="HOGENOM" id="CLU_2802412_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="67" mass="7931" checksum="C218EE98AD699817" modified="2014-10-29" version="1">MIIHLPQGRQITRNRYWTNFQLLFGHVDLGCYDGKKFCLFKCHEHGVVLDYERGYEGHLNCPLCSMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNV8</accession>
    <name>A0A075MNV8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nitroreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_00742</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nitroreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNV8"/>
    <dbReference type="STRING" id="1459636.NTE_00742"/>
    <dbReference type="KEGG" id="nev:NTE_00742"/>
    <dbReference type="eggNOG" id="arCOG00288">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070764_6_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02138">
        <property type="entry name" value="TdsD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="entry name" value="NADH Oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43673">
        <property type="entry name" value="NAD(P)H NITROREDUCTASE YDGI-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43673:SF10">
        <property type="entry name" value="NADH DEHYDROGENASE_NAD(P)H NITROREDUCTASE XCC3605-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="FMN-dependent nitroreductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="3">
        <location>
            <begin position="23"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Nitroreductase" evidence="3">
        <location>
            <begin position="82"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF82820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="200" mass="22414" checksum="F2770EFEF87D684C" modified="2014-10-29" version="1">MLCVKQEQQALGRKATYEINPLILNRWSARAMSGEALSHEELMPLFEAARWAPSAFNGQPWRFVYAKRDTPHWSRLFGLLMDLNKSWAKDAAALAVVVSKKTSDYNGQPNATHQFDTGAAWQNLALEATSRGLVAHAMGGFDHDGARHELDLPDDYEPLAMVAIGRPAPKEKLDPALREREYPSDRKPLAEIVMEGKFRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MP42</accession>
    <name>A0A075MP42_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01219</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MP42"/>
    <dbReference type="STRING" id="1459636.NTE_01219"/>
    <dbReference type="KEGG" id="nev:NTE_01219"/>
    <dbReference type="HOGENOM" id="CLU_3338261_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="37" mass="4324" checksum="8B70F81FE73D79C7" modified="2014-10-29" version="1">MNKITIPPIMEREEALERVALFLIAKEVSVLRKWLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MP56</accession>
    <name>A0A075MP56_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Type VI secretion system effector, Hcp1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00869</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987156.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MP56"/>
    <dbReference type="STRING" id="1459636.NTE_00869"/>
    <dbReference type="GeneID" id="41596711"/>
    <dbReference type="KEGG" id="nev:NTE_00869"/>
    <dbReference type="HOGENOM" id="CLU_112762_0_3_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.20">
        <property type="entry name" value="Hcp1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036624">
        <property type="entry name" value="Hcp1-lik_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053165">
        <property type="entry name" value="HSI-I_assembly_Hcp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008514">
        <property type="entry name" value="T6SS_Hcp"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03344">
        <property type="entry name" value="VI_effect_Hcp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36152">
        <property type="entry name" value="CYTOPLASMIC PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36152:SF5">
        <property type="entry name" value="PROTEIN HCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05638">
        <property type="entry name" value="T6SS_HCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141452">
        <property type="entry name" value="Hcp1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="209" mass="21614" checksum="647D80227675F2F6" modified="2014-10-29" version="1">MPNLGKMQVVASVAVVTSILAGYVAVASFSSASQKISASEALLGIPSADAATVDYFLKIDGIEGESTSDRHKGEINIESFSWGASNTGSASAGGGAGAGKVSFQDISFTKVIDKSSPKLMLATATGQHIKQVTLTGEMSGKKGQQFLQIKLTDVLISSYQQGGSSGAVPTDSFSLNFAKIEFTYYPTNPDGSLGAPMTGGWDIKENKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MP61</accession>
    <name>A0A075MP61_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Coenzyme F420-0 gamma-glutamyl ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NTE_01256</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MP61"/>
    <dbReference type="STRING" id="1459636.NTE_01256"/>
    <dbReference type="KEGG" id="nev:NTE_01256"/>
    <dbReference type="eggNOG" id="arCOG02714">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051152_1_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052618">
        <property type="term" value="F:coenzyme F420-0:L-glutamate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.100">
        <property type="entry name" value="CofE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1660.10">
        <property type="entry name" value="CofE-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008225">
        <property type="entry name" value="F420-0_g-glutamyl_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002847">
        <property type="entry name" value="F420-0_gamma-glut_ligase-dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01916">
        <property type="entry name" value="F420_cofE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47917">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47917:SF2">
        <property type="entry name" value="COENZYME F420:L-GLUTAMATE LIGASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01996">
        <property type="entry name" value="F420_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144010">
        <property type="entry name" value="CofE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Coenzyme F420:L-glutamate ligase-like" evidence="8">
        <location>
            <begin position="21"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF83326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="250" mass="27138" checksum="904AD83F958D8339" modified="2014-10-29" version="1">MEILTVKVARKSGRFNLFESLQGFDYKDGDIIVVSSKFVSMAEGSVVDMGRIRVSRKAKVLAKKCHMEPRLAELVLRESDYIVKGVPGFLLAIRDGMIAPNAGIDKSNVPKGFAILYPRDPFASAEDLKDAFLANLGIKVGIVIADSRLMPTRIGTTGVAIACAGFEPVEDLRGKKDLFGNVLRVTFRAVADGLATMGVAAMGESDESTPAAVVRGARVQWTDKRLSWRDMAVAPEQDIYLRGLKSESLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPB0</accession>
    <name>A0A075MPB0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00551</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPB0"/>
    <dbReference type="KEGG" id="nev:NTE_00551"/>
    <dbReference type="eggNOG" id="arCOG12810">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025660_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="560" mass="60412" checksum="B4EB57AEA3F0B430" modified="2014-10-29" version="1">MRASSNVHVIVTVTFMVLILAGSLAHSLLPSLGVGAAEGAQSKVLIVNALSLPSNGSNKPISIPVEIWSGDHPPSVPPPPPNHGQENQQQALKKGNTPMAFVGKEGATYVVKVNDNQQFTFDHWKDGDTNSVKQVKLSKSLPVIELTAFFKKKTEPPSPSSTLVVNALTANGEPLHMSATIRSGKAVVKTGLLTPFTFHGTPGKTYTLTLDEKNNGKSAVAASSLSSFPILGNDDSGGNKKQPDQSKKGALPPLSVIFNHWNDTGNTNRVRSITMPANDGGVLKLVGIYNKGDRVTLEDLGVLQLVSHDLYNTIRDGPNPGSIEDERLNLSTLLDHGDDQIILGGEPRNSENIAIHTVAVNLGKMYLGLVGSGIDPADARNQTIQVYLAKLEKAYNHAFHEPLPAPAPNPHEEKPDSAENLTGDLSLRAVHSYVPGHIMVNGVDTPILDPSLRGKTLSAKDMQQLSKPLDGTFDPVFRNVTIFLPPPNPPPNLFTIDLFERDSSFAKQFGTDVSFEEFMGELKDGRFDKDEQVMNYLREDVAAGLLLSSSEEDNEEEVDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPL7</accession>
    <name>A0A075MPL7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_01442</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700266.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPL7"/>
    <dbReference type="STRING" id="1459636.NTE_01442"/>
    <dbReference type="GeneID" id="41597237"/>
    <dbReference type="KEGG" id="nev:NTE_01442"/>
    <dbReference type="eggNOG" id="arCOG01389">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020629_1_0_2"/>
    <dbReference type="OrthoDB" id="46222at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43630">
        <property type="entry name" value="POLY-BETA-1,6-N-ACETYL-D-GLUCOSAMINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43630:SF1">
        <property type="entry name" value="POLY-BETA-1,6-N-ACETYL-D-GLUCOSAMINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13641">
        <property type="entry name" value="Glyco_tranf_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="305"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="351"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="389"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF83506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="434" mass="48981" checksum="2584C6B455667FAA" modified="2014-10-29" version="1">MAALAAFAALAPSAFLFSLAVGITAIYTAWGVYHLVVAMSGIKPPMSFDTRLEAYPKISVIIPARNEPILGRTIESCLYHVDYPLDKKEIIVVVDDEGGERIAFWYQQKHPEAVKVLARRQFFPTKPSALNDAMLLCSGEIVVIMDVEDIPDRDVFKKAAAAIQGGGKQAVQVMLRIGNTEDSWISKIFAMEYAGWFRIMLNGRSNLGMFAPLGGTGNYFSRAALRYVGGYEPTNLAEDAELAIRLRIARWNVSTLDARHWEEAPVKFDAWLKQRTRWFRGWMQSFWKYSGILLLQPTVAKRMGFLGIFSTLVMLVSPLIVVLNLVAYAITALWLLGGSGLVPRLITADTVPFWTIIPLGFNGLYYYIWIKGARLEGIEVKTLKYLPHMFFYMNVMMPIASLRAFYQELFKSVFWEKTTHHGRGVRSTAVEKHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPN8</accession>
    <name>A0A075MPN8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ammonia monooxygenase/methane monooxygenase, subunit C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699988.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPN8"/>
    <dbReference type="STRING" id="1459636.NTE_01100"/>
    <dbReference type="GeneID" id="41596916"/>
    <dbReference type="KEGG" id="nev:NTE_01100"/>
    <dbReference type="eggNOG" id="arCOG08699">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1444620_0_0_2"/>
    <dbReference type="OrthoDB" id="5728at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22188">
        <property type="entry name" value="arch-AMO_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.50">
        <property type="entry name" value="Particulate methane monooxygenase subunit c2. Chain: C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006980">
        <property type="entry name" value="NH3_CH4_mOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023349">
        <property type="entry name" value="NH3_CH4_mOase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04896">
        <property type="entry name" value="AmoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="187" mass="21117" checksum="F6E6EB942E3DBCD5" modified="2014-10-29" version="1">MAQMPALIPKEVEIQRLKKIYIMVIMLGSIAASVEVDNFVDGSLHQTAIRDSAFTPAHWWLYSHFVALPVGWGMVAVYDRRVPILRGPGNSMNTGLKITIIGYLATMFTIGVNEMWHFWFVEEIFSVPNHWMFNMGVVVAFMGALAYVVRVYARLVELGAETPAKNPYVAEMYKLALEGKLYSRSIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPU4</accession>
    <name>A0A075MPU4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nicotinamidase-like amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_00794</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987148.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPU4"/>
    <dbReference type="STRING" id="1459636.NTE_00794"/>
    <dbReference type="GeneID" id="41596644"/>
    <dbReference type="KEGG" id="nev:NTE_00794"/>
    <dbReference type="eggNOG" id="arCOG01943">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068979_8_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00431">
        <property type="entry name" value="cysteine_hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050272">
        <property type="entry name" value="Isochorismatase-like_hydrls"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540:SF9">
        <property type="entry name" value="FAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540">
        <property type="entry name" value="PEROXYUREIDOACRYLATE/UREIDOACRYLATE AMIDOHYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="3">
        <location>
            <begin position="79"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF82872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="294" mass="32817" checksum="5BD11B10C6BA8AA6" modified="2014-10-29" version="1">MTKEKMPQPPTPNRDFTSAAREEVLKRVEKDYEEFKKTKTFKFPAWLYGPPRGKLFKVEVEDCPRFGDKAWVEFDSARTAFVSIDMQIDFCGPKGYVDVMGYDLGLTSAPIKPIHYVLHNIRNGTDIKVIHTREGHLPDLSDAPYNKVLRSKIIGDGVGIGDIPKGGLGRLLTRGEKNWDIIDDLYPMPGEYVIDKAGKGAFGQSNMPLLLKNLGITHLVITGITTDVCVHTIMREANDYGYWCLLLKDGTGATDYGNYQAAIKQIKMQGGVFGWVSDSKKFIDGVRSAFPDTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPW4</accession>
    <name>A0A075MPW4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptide methionine sulfoxide reductase MsrA</fullName>
            <shortName evidence="2">Protein-methionine-S-oxide reductase</shortName>
            <ecNumber evidence="2">1.8.4.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Peptide-methionine (S)-S-oxide reductase</fullName>
            <shortName evidence="2">Peptide Met(O) reductase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">msrA</name>
        <name evidence="4" type="ORF">NTE_00819</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-methionyl-[protein] + [thioredoxin]-disulfide + H2O = L-methionyl-(S)-S-oxide-[protein] + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:14217"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12315"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:44120"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>[thioredoxin]-disulfide + L-methionine + H2O = L-methionine (S)-S-oxide + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:19993"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58772"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MsrA Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.11" evidence="2"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699774.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPW4"/>
    <dbReference type="STRING" id="1459636.NTE_00819"/>
    <dbReference type="GeneID" id="41596664"/>
    <dbReference type="KEGG" id="nev:NTE_00819"/>
    <dbReference type="eggNOG" id="arCOG02816">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031040_10_0_2"/>
    <dbReference type="OrthoDB" id="7150at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033744">
        <property type="term" value="F:L-methionine:thioredoxin-disulfide S-oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008113">
        <property type="term" value="F:peptide-methionine (S)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1060.10">
        <property type="entry name" value="Peptide methionine sulphoxide reductase MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01401">
        <property type="entry name" value="MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002569">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036509">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00401">
        <property type="entry name" value="msrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43774">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43774:SF1">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE MSRA 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01625">
        <property type="entry name" value="PMSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55068">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptide methionine sulphoxide reductase MsrA" evidence="3">
        <location>
            <begin position="2"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="9"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF82897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="159" mass="18122" checksum="C19C28191728F55D" modified="2014-10-29" version="1">MKATFGMGCFWCSEDVFGRVKGVKSTTVGYMGGKIEHPTYEQVCTDRTGHAEVVQIEYDPAQVSYEEILSVFWANHDPTIPNRQGWDVGTQYRSAVFYHSPEQKAAAEAIKQKLQDSGAFKRKIVTEVSPASAFWKAEEYHQKYYQKCGLKMHGYGTFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQ11</accession>
    <name>A0A075MQ11_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01191</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700057.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQ11"/>
    <dbReference type="GeneID" id="41597001"/>
    <dbReference type="KEGG" id="nev:NTE_01191"/>
    <dbReference type="HOGENOM" id="CLU_199455_0_0_2"/>
    <dbReference type="OrthoDB" id="10068at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="75" mass="8864" checksum="77700F48F9404A7C" modified="2014-10-29" version="1">MKKCAACARESGDKKYCRYHAKALEQLKSHYDSWVDAYDDGSAISWQDYLTRLQKMEEAGQWVREVIEAEMKKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQ20</accession>
    <name>A0A075MQ20_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleoside diphosphate kinase</fullName>
            <ecNumber evidence="3">2.7.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">NTE_01201</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">SR1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 13 14">Belongs to the NDK family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="3"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700066.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQ20"/>
    <dbReference type="STRING" id="1459636.NTE_01201"/>
    <dbReference type="GeneID" id="41597010"/>
    <dbReference type="KEGG" id="nev:NTE_01201"/>
    <dbReference type="eggNOG" id="arCOG04313">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060216_6_3_2"/>
    <dbReference type="OrthoDB" id="6874at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04413">
        <property type="entry name" value="NDPk_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.141:FF:000003">
        <property type="entry name" value="Nucleoside diphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001908">
        <property type="entry name" value="PRK00668.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11349">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51374">
        <property type="entry name" value="NDPK_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside diphosphate kinase-like" evidence="15">
        <location>
            <begin position="3"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="13">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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    <feature type="binding site" evidence="13">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012966"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00017632"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00706"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AIF83273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="134" mass="14747" checksum="94240EE5B5A6D597" modified="2014-10-29" version="1">MAVEQTLIVVKPDGFRRGLTGKILARFEEKGFLIKNLRYYNFTKEKAQEFYSVHKAKPFFGELVSFISSGPVVACILEGNNAVGTTRIMIGATKSFEAAPGTIRGDFGLGFTDNIIHASDSSESFIKESRVIFG</sequence>
</entry>
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    <accession>A0A075MQ34</accession>
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        <name evidence="6" type="ORF">NTE_01608</name>
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            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
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                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6 7">SR1</strain>
        </source>
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    </dbReference>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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            <begin position="34"/>
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        </location>
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            <begin position="181"/>
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        </location>
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        </location>
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    <feature type="binding site" evidence="3">
        <location>
            <position position="41"/>
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        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
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        <ligand>
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        </ligand>
    </feature>
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        <ligand>
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        </ligand>
    </feature>
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        <ligand>
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        </ligand>
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        <ligand>
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        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022434"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF83671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="200" mass="22717" checksum="0EF0A518232EFE33" modified="2014-10-29" version="1">MSEDNHHNNDKINVVGINVLKQNGANVDEIVRLLVYNASVEFTAYYYFTNLRAHCTGLDGEGLKGVIEDARLEDLSHFESCIQRIYELGGTLPNDAMEFVRMSGCEFLQLPTPTTNIQEILKKCLAAEQGAIVNWNKLCNLTIGKDPATYEIAKDILKEEIEHEAWFLELIYGRPSGHMRRKYAGERPHTHKHSRALSQL</sequence>
</entry>
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    <accession>A0A075MQ48</accession>
    <name>A0A075MQ48_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
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    <dbReference type="STRING" id="1459636.NTE_01232"/>
    <dbReference type="KEGG" id="nev:NTE_01232"/>
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    <dbReference type="Proteomes" id="UP000028194">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="147" mass="15439" checksum="B56E46F230E81996" modified="2014-10-29" version="1">MFFLFLVTYAHDGNAVQAAAAVALAAVAVAAAGALIAFGDISYRMQDGKTVSIIGQMVCLPHKQDLFGRYGTGLCVPGFKGSDGSHYALSNIEQLSRGEPALGFTNAQFQISGVFSYGATEQYRNYDVAGMIEADSVLPISPPPAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQA2</accession>
    <name>A0A075MQA2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fructose-2,6-bisphosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_00987</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
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                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AIF83062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQA2"/>
    <dbReference type="STRING" id="1459636.NTE_00987"/>
    <dbReference type="KEGG" id="nev:NTE_00987"/>
    <dbReference type="eggNOG" id="arCOG01991">
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    <dbReference type="Proteomes" id="UP000028194">
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    </dbReference>
    <dbReference type="GO" id="GO:0005737">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF1">
        <property type="entry name" value="HISTIDINE PHOSPHATASE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="1">
        <location>
            <position position="3"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="2"/>
            <end position="9"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF83062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="201" mass="22988" checksum="FD9F6B633C7DFB29" modified="2014-10-29" version="1">MRHGQADNNVNRILVGRHIESHLTEQGRKQVEYAAKDLKNVQIDRVVVSPVIRAVETAEIICKEVGTGYEIDERLYEIELGKLVGMNFDEVVSKYGNLFLKFYDEHDPALESFGVEPFTSVKKRVKSLLEEAAEKHVDRNILCVTHLDPIKAAISTILELNPEALYRWHIRNASMTILRQDDGLYSLSGVNVMSMHRYVHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQE2</accession>
    <name>A0A075MQE2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative signal-transduction protein containing cAMP-binding and CBS domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_01690</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQE2"/>
    <dbReference type="STRING" id="1459636.NTE_01690"/>
    <dbReference type="KEGG" id="nev:NTE_01690"/>
    <dbReference type="eggNOG" id="arCOG00606">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040681_12_1_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051257">
        <property type="entry name" value="Diverse_CBS-Domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43080:SF2">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43080">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN CBSX3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="26"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="97"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF83751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="156" mass="17211" checksum="AFD33EB7F7ACCF4C" modified="2014-10-29" version="1">MLFCGQIYTYMERAGRAVSLKAGKVADKAFVSMDENTLVADAAKTMYERKECTIIVTRNDPNTRSRIPAGIITERDIIYRIVAQNRGPFKVTLKDIMSAPLITVDSEATAEQALSIMKENDIGRLPVISRKGVIMGLLTMKMLVKRVSIGNAAQAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQE9</accession>
    <name>A0A075MQE9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">2-oxoacid:acceptor oxidoreductase, beta subunit, pyruvate/2-ketoisovalerate family</fullName>
            <ecNumber evidence="12">1.2.7.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NTE_01234</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SR1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.2.7.3" evidence="12"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700096.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQE9"/>
    <dbReference type="STRING" id="1459636.NTE_01234"/>
    <dbReference type="GeneID" id="41597042"/>
    <dbReference type="KEGG" id="nev:NTE_01234"/>
    <dbReference type="eggNOG" id="arCOG01599">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048564_0_0_2"/>
    <dbReference type="OrthoDB" id="30755at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047553">
        <property type="term" value="F:2-oxoglutarate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044272">
        <property type="term" value="P:sulfur compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03375">
        <property type="entry name" value="TPP_OGFOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053399">
        <property type="entry name" value="2-oxoacid:Fd_oxidored_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051457">
        <property type="entry name" value="2-oxoacid:Fd_oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011896">
        <property type="entry name" value="OFOB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032686">
        <property type="entry name" value="PFO_beta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041171">
        <property type="entry name" value="Oxoac_fdxbeta_Archa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02177">
        <property type="entry name" value="PorB_KorB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48084">
        <property type="entry name" value="2-OXOGLUTARATE OXIDOREDUCTASE SUBUNIT KORB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48084:SF2">
        <property type="entry name" value="PYRUVATE FERREDOXIN_FLAVODOXIN OXIDOREDUCTASE, BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12367">
        <property type="entry name" value="PFO_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="10">
        <location>
            <begin position="49"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate ferredoxin oxidoreductase beta subunit C-terminal" evidence="11">
        <location>
            <begin position="200"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIF83305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="325" mass="35850" checksum="4A674784B9614525" modified="2014-10-29" version="1">MALKLADYKTDVHNDWCPGCGDFGILNSIQMALADMQIPPHKATIFSGVGCSGKTPHFIRTYGIHTLHGRVMPFAQGAKLSNPDLEVIAVGGDGDGLGIGAGHFVSAGRRNVDMTYIIFNNAVYGLTKGQASPTLKLGMKTKSLPQPNVNNSVNPIALALVAGFTFIARGYSYDVRHLKDLIKKAVEHKGLAFVDVLQPCPTYNDINTKEWFSGSNNIDPVTKKVMPRIYKLEETGYDGIVRDPAEINEKMGKVIEKANEWGDKIPIGVFYQNEHIPTFQERISARIPNYVESPPAKQEIADLSGKTITNIEKLLDDYRLDRENF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQF5</accession>
    <name>A0A075MQF5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQF5"/>
    <dbReference type="KEGG" id="nev:NTE_01240"/>
    <dbReference type="eggNOG" id="arCOG08678">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_186514_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="92" mass="10521" checksum="26C0DAA6CFFB7143" modified="2014-10-29" version="1">MSSTYINFLWNLLHFIAIALFGMTFIPPSYTRQLLQNMAKSAGKCAVCGADLTFKYRPMEGWNVSGFICGSCYSQKLLEHYIEPDRRSITKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQL4</accession>
    <name>A0A075MQL4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01307</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700158.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQL4"/>
    <dbReference type="STRING" id="1459636.NTE_01307"/>
    <dbReference type="GeneID" id="41597109"/>
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    <dbReference type="eggNOG" id="arCOG10523">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2216928_0_0_2"/>
    <dbReference type="OrthoDB" id="5972at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="119" mass="13969" checksum="03321F925F85B28D" modified="2014-10-29" version="1">MLKSPQQEKFAEKSEDKGKHASSTENRRMVWENVVWPLILDINRSYFTLKEYHAKRNEFCRATGVPPSRVAGGFVSLLIKGIIARNKNIYSIHYRLIPYMRKKAQLEYGQVIREVNTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQN3</accession>
    <name>A0A075MQN3_9ARCH</name>
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            <fullName evidence="5">Threonine synthase</fullName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_01785</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="4.2.3.1" evidence="5"/>
    <dbReference type="EMBL" id="CP007174">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQN3"/>
    <dbReference type="STRING" id="1459636.NTE_01785"/>
    <dbReference type="GeneID" id="41597551"/>
    <dbReference type="KEGG" id="nev:NTE_01785"/>
    <dbReference type="eggNOG" id="arCOG01434">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028142_5_0_2"/>
    <dbReference type="OrthoDB" id="6371at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:threonine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004795">
        <property type="term" value="F:threonine synthase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006565">
        <property type="term" value="P:L-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01563">
        <property type="entry name" value="Thr-synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000013">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050147">
        <property type="entry name" value="Ser/Thr_Dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078:SF6">
        <property type="entry name" value="L-THREONINE DEHYDRATASE CATABOLIC TDCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0456">Lyase</keyword>
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        <location>
            <begin position="117"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF83846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="446" mass="49259" checksum="52EECA0393593A38" modified="2014-10-29" version="1">MAEHAIKKCINPDCGKSYGIDNDIYRCTCGSLLDIKYSKRPSRDLIERFYQRRNHGGNIYNESGVWRFRDLVNFAGIDTEDFNECARVLVSLDGSEGRLSKPYNMSKAADYADMSHDSFFLQPEGYNPSGSFKDNGMSTAVTHAKMLKVKKIICASTGNTSASAAMYAANEDIQCDVYIPKGEIAPGKLGQAFQFGAQVIQVQGNFDDALATSLKNAKETGGYTVNSVNPFRIEGQKTIVYRVMEHLNWNPPDWIVYPGGALGNTSSCGKALIELYEWGWIKKIPRIVVVNAEGANTLYELYNGMFEGKKLSWNDGRPDLGMVDRYYADLDKQGIRPKTHATAIQIGRPANIVKALRALHFTNGIVVQATDREMSDGMSIVGLNGFDCEMASGAVPAGVRKLRKEGTIKKDDVVVGILTGRQKDPSLAVEYHMNADNMFARPPTNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQW0</accession>
    <name>A0A075MQW0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01421</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="STRING" id="1459636.NTE_01421"/>
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    <dbReference type="eggNOG" id="arCOG10585">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2392743_0_0_2"/>
    <dbReference type="OrthoDB" id="10573at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="98" mass="10671" checksum="D69A3C3BDA9444CE" modified="2014-10-29" version="1">MKSLKFACDDRYEAEKLAGLVSVQKDGTVYVDGVTAVIGNEIVIKLKDKSSHAVVLKDRENVTKLEALLCDIAKGKTTIVSSDFEGAVAEIKIKEEQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQY6</accession>
    <name>A0A075MQY6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01456</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
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    </dbReference>
    <dbReference type="RefSeq" id="WP_148700279.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQY6"/>
    <dbReference type="STRING" id="1459636.NTE_01456"/>
    <dbReference type="GeneID" id="41597251"/>
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    <dbReference type="HOGENOM" id="CLU_2217139_0_0_2"/>
    <dbReference type="OrthoDB" id="372908at2157"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="107" mass="12372" checksum="5D509B45AB82B2DF" modified="2014-10-29" version="1">MAGGLRMIKIDFYVPTKTKDGRDIDPKKVDDIINQIWPRYRGATKLTGTGYYRAKSGKDEVTESYLLSIITGYDKPFKADLKKFKEKIRNELCQETVLITWHSIKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRR9</accession>
    <name>A0A075MRR9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02157</name>
    </gene>
    <organism evidence="1 2">
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        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
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            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
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            <taxon>Nitrososphaeraceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700826.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRR9"/>
    <dbReference type="STRING" id="1459636.NTE_02157"/>
    <dbReference type="GeneID" id="41597881"/>
    <dbReference type="KEGG" id="nev:NTE_02157"/>
    <dbReference type="HOGENOM" id="CLU_2874903_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="63" mass="6913" checksum="ADDD826313B75D2B" modified="2014-10-29" version="1">MARHLSDKKERIADAYDKLGTLGVNVQAIRKMNLSADQLEDIYHGIASLAEKHRTLFGKGCGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRX2</accession>
    <name>A0A075MRX2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Flavodoxin reductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NTE_02202</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SR1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700863.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRX2"/>
    <dbReference type="STRING" id="1459636.NTE_02202"/>
    <dbReference type="GeneID" id="41597923"/>
    <dbReference type="KEGG" id="nev:NTE_02202"/>
    <dbReference type="eggNOG" id="arCOG02200">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG02852">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_709037_0_0_2"/>
    <dbReference type="OrthoDB" id="35401at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00322">
        <property type="entry name" value="FNR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050415">
        <property type="entry name" value="MRET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47354">
        <property type="entry name" value="NADH OXIDOREDUCTASE HCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47354:SF6">
        <property type="entry name" value="NADH OXIDOREDUCTASE HCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="10">
        <location>
            <begin position="5"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="11">
        <location>
            <begin position="144"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIF84256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="397" mass="43680" checksum="F1FD7E9D5B7FAE80" modified="2014-10-29" version="1">MPRYTTALRKGDLQEGKPVRVDVGGKAIVLVMVSGKVYAMDAVCSHEGGPLEDGTIEEYSLICPWHQGIFDIRTAKASPETDWVTDLHSYGVVIEDKSGLISIDTNPSASNSPSSVGGGGGASHGIAPQETAVAEEDVVVPARPLKFELKLLEKVSHAGTDVMSFRFSRTDDQDKTSNNKLNYRAGQYSVVDLGTREDPEGPTRSFTIASSPTEKDAIMITTRIRDTPFKQKLSKLEEGTAVKITAPAGKFTLPEEDYSRPLVFLSGGIGVTPFRSMIKYASDKQLPIKITMFDANRNKANIIFKEEFDSCAKANAKLKIIYTISEEEAKIPSSDWNGERGYIDKTMLTKYLTKDELANSIFYICGPPAMLNAMRQLLSEEIRVPQDRIKIEVFTGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRX7</accession>
    <name>A0A075MRX7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">P-type Cu(+) transporter</fullName>
            <ecNumber evidence="3">7.2.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">NTE_02207</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.8" evidence="3"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700868.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRX7"/>
    <dbReference type="STRING" id="1459636.NTE_02207"/>
    <dbReference type="GeneID" id="41597928"/>
    <dbReference type="KEGG" id="nev:NTE_02207"/>
    <dbReference type="eggNOG" id="arCOG02763">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001771_0_3_2"/>
    <dbReference type="OrthoDB" id="8588at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043682">
        <property type="term" value="F:P-type divalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140581">
        <property type="term" value="F:P-type monovalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055070">
        <property type="term" value="P:copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd02094">
        <property type="entry name" value="P-type_ATPase_Cu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000005">
        <property type="entry name" value="Copper-exporting P-type ATPase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000144">
        <property type="entry name" value="copper-transporting ATPase 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000002">
        <property type="entry name" value="Copper-transporting ATPase 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006122">
        <property type="entry name" value="HMA_Cu_ion-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01511">
        <property type="entry name" value="ATPase-IB1_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00003">
        <property type="entry name" value="copper ion binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520">
        <property type="entry name" value="ATP7, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520:SF8">
        <property type="entry name" value="P-TYPE CU(+) TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00943">
        <property type="entry name" value="CUATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-0186">Copper</keyword>
    <keyword evidence="11" id="KW-0187">Copper transport</keyword>
    <keyword evidence="21" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="18 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="14" id="KW-1278">Translocase</keyword>
    <keyword evidence="7 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="230"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="445"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="770"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="20">
        <location>
            <begin position="14"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="20">
        <location>
            <begin position="82"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="AIF84261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="822" mass="85770" checksum="E63E9D01B93D4AEC" modified="2014-10-29" version="1">MEKEASTQAENNNKKALLKIGGMHCAGCVNSIQRHVSTVDGVSKVEVNLASEKAAVEFDPAKVGLPDIEKAIEEVGYKVVYEKVSLKVGGITDSADAQRLEEGVSRMEGVRSASANYGNAQVLVEYNPALVSLADIRKKVGDYGYSVIGESAQASAHDIEARKLKGLFLLGVAFTIPAVLFSYPEVFSFLPLAGTNAAAYIAFAAASVVQFVTGGRFYSGAFRIARMKSANMDTLVVLGTTATYAFSAYNTFPVPTWHGIYYDASSLVITFILLGKYLELKTKGKTGAVIRKMLELQPKTARVKKADGSEVETRVELIQPGDIMIVRPGEKIPVDSTVVQGESAVDESMATGESAPVHKKSGDSAIGGTVNREGVLLVKATRVGSDSFLSQVVKLVEEATGKKPTMQKLVDRVAGYFAYAVMAVAIATFGVWYALAASSAGTEAAIIPAVAILVVACPCALGLATPTAIMVGMGKGAAHGVIFKSGDAIEALSKVKAIVFDKTGTLTQGRPQVTDVIQLKQEIGAQGQSVQDSNAGVLLLAATAENYSEHPLAKAIVGHAKGAGIEPKEVSDFQVTPGMGVTAVWDGVTVRVGSREFIEEEAGMGTSSSAQSVVEKLQSQGKTAVLVSANSDVVGVIGLMDAPKQGAREAIEALKGLGIEPVMVTGDNRRTAEEIARQVGIERVYAGVLPSGKVDAINEIRNKNGIVAMVGDGINDAPALTAADVGMAIGSGTDLAIEAGNIVLVKSDIRDVVSAVEIARKTVGKIKQNLAYAFLYNVVLIPVAAMGLLYPALAGLAMAASSVSVTASSLALKRWRPGLAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MS16</accession>
    <name>A0A075MS16_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Proteasome subunit beta</fullName>
            <ecNumber evidence="9">3.4.25.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">20S proteasome beta subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Proteasome core protein PsmB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">psmB</name>
        <name evidence="10" type="ORF">NTE_01899</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.25.1" evidence="9"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226986920.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MS16"/>
    <dbReference type="STRING" id="1459636.NTE_01899"/>
    <dbReference type="GeneID" id="41597649"/>
    <dbReference type="KEGG" id="nev:NTE_01899"/>
    <dbReference type="eggNOG" id="arCOG00970">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035750_7_2_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02113_A">
        <property type="entry name" value="Proteasome_B_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019983">
        <property type="entry name" value="Pept_T1A_Psome_bsu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF0">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE SUBUNIT HSLV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0645">Protease</keyword>
    <keyword evidence="7 9 10" id="KW-0647">Proteasome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0888">Threonine protease</keyword>
    <keyword evidence="8 9" id="KW-0865">Zymogen</keyword>
    <feature type="propeptide" id="PRO_5005001810" description="Removed in mature form; by autocatalysis" evidence="9">
        <location>
            <begin position="1"/>
            <end position="8"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023284454" description="Proteasome subunit beta" evidence="9">
        <location>
            <begin position="9"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIF83958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="200" mass="21680" checksum="96BC3096B29158AF" modified="2014-10-29" version="1">MAFEFMPGATVVGISYSNGVVLAADKRISFGNFVVNKNMKKTFPVTPHVGAACAGMVADMTVLVRQVEALAKIRKLETRREVAPNSVAKLMSVIMFERRYFPLLTQVIVGGVNDKPEIYTLDPLGSVLPDQYAAVGTGAEMALGIMDAEFKQDMSEENARELAIRAVRSATQRDAASGDGIEVLVVSRNGTREETVPIRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSE4</accession>
    <name>A0A075MSE4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700727.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSE4"/>
    <dbReference type="STRING" id="1459636.NTE_02026"/>
    <dbReference type="GeneID" id="41597769"/>
    <dbReference type="KEGG" id="nev:NTE_02026"/>
    <dbReference type="HOGENOM" id="CLU_2103383_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="115" mass="12674" checksum="40AD35AFFC873954" modified="2014-10-29" version="1">MSAVRKIAGVKSSAWTRRALPVLTKLAVVAILAAGLISISMYTSVAQVYAAVTKPHVITGDTPELVKHEGLEPEPQPWEDGMRTDPTSNTYEWWYFEAVLDDNSTAIFTFFKALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSG1</accession>
    <name>A0A075MSG1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00202</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSG1"/>
    <dbReference type="KEGG" id="nev:NTE_00202"/>
    <dbReference type="HOGENOM" id="CLU_2856916_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="64" mass="7196" checksum="23BC4414EFD3AA9C" modified="2014-10-29" version="1">MLTQVSTNEPLYGKVEHIIISHEKMKAFLVPIDQEHYLGIGCAKPYDAAIIIRNAERIMAEADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSK3</accession>
    <name>A0A075MSK3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">D-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="7">1.1.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NTE_01711</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.4" evidence="7"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSK3"/>
    <dbReference type="STRING" id="1459636.NTE_01711"/>
    <dbReference type="KEGG" id="nev:NTE_01711"/>
    <dbReference type="eggNOG" id="arCOG00337">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017779_9_2_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004458">
        <property type="term" value="F:D-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008720">
        <property type="term" value="F:D-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903457">
        <property type="term" value="P:lactate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748:SF111">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="8">
        <location>
            <begin position="46"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF83772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="507" mass="54992" checksum="6B8DE97B8566EEC4" modified="2014-10-29" version="1">MKFVILAPPRLGILTTIGDGLARIAKGEVLSDEWSRQVYSMDASHYEIKPALAACPKDAGDVQAICHYAFSKKVPLTGRGAGTGLLGQSLSDGGLVLDFAKHMNRVLEVGDDYVVVEPGIVKGILDKELKKRNKFLPPDPASSNYCTIGGMIADNSSGVHCLGYGNTIDFIEALDLVYANGSAGHADKNSFDARMEKLRGLLGQSAEMINSSYPRVSKNSCGYRLDAAIRHGFEPHKVISASEGTLALVTSARFRILDLPLHRFLLVLGFEDLLAAVRAVPAILESSPVALEMLDATVLALEKNAETGCLLYVEFAGDNRTQVEAQMARCQQRMMTAAGTRIVEYATDEQSLTRIWAARKGALGNIMKLTVGSRKPVGLVEDTVVRPEMLAAHTENLLAAYRDNNLCYVMYGHVGDGNIHTRPLVDTGSKAESEMIRALAARVFAQVIANGGTITGEHGDGLARVGYIEQMYGKKMTALFKTVKELFDPDYLLNPGKKVPFKSRRNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSM1</accession>
    <name>A0A075MSM1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1428 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02074</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700761.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSM1"/>
    <dbReference type="STRING" id="1459636.NTE_02074"/>
    <dbReference type="GeneID" id="41597808"/>
    <dbReference type="KEGG" id="nev:NTE_02074"/>
    <dbReference type="HOGENOM" id="CLU_1840470_0_0_2"/>
    <dbReference type="OrthoDB" id="8813at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009874">
        <property type="entry name" value="DUF1428"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07237">
        <property type="entry name" value="DUF1428"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="139" mass="16057" checksum="0CB5BD4D6360FE96" modified="2014-10-29" version="1">MNNNNKTESAAQKTTATTSSSSHLEAFLYRVPKKNHDAVAQNLKQFVPWFEKQGVRIEYYQLGNYKIMEGIDGIAKTLSAGEDEDIWMELQYFRDYKHCEDAYAKMMQDKSIEQLGKEFFGLITQGTSLVNGRFNRLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSV8</accession>
    <name>A0A075MSV8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01811</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700567.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSV8"/>
    <dbReference type="GeneID" id="41597576"/>
    <dbReference type="KEGG" id="nev:NTE_01811"/>
    <dbReference type="eggNOG" id="arCOG08721">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_127468_0_0_2"/>
    <dbReference type="OrthoDB" id="12086at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="180" mass="20005" checksum="F0857C2F5B602F61" modified="2014-10-29" version="1">MRKDVKQVLYAVIDDIGREKIRADVSSDIESSKKYCAEIMKRCMRDLGDEANDDETLGNLCEALLHFMLTASLLPSERKVTVDGMELDIVVPSVKSLAKNPDKTLVIQVVKTSADLAKVKQAQAVQKNAENLWIISARKIEYKGRNYHLGNANLQYSSAVSDIHAFLARKGVSSLKMLHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSY9</accession>
    <name>A0A075MSY9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GTPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02251</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSY9"/>
    <dbReference type="STRING" id="1459636.NTE_02251"/>
    <dbReference type="KEGG" id="nev:NTE_02251"/>
    <dbReference type="eggNOG" id="arCOG00353">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1673904_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030394">
        <property type="entry name" value="G_HFLX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016496">
        <property type="entry name" value="GTPase_HflX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10229">
        <property type="entry name" value="GTP-BINDING PROTEIN HFLX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10229:SF8">
        <property type="entry name" value="GTPASE HFLX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51705">
        <property type="entry name" value="G_HFLX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hflx-type G" evidence="1">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="157" mass="17200" checksum="6AD8BBB79A8D8CA4" modified="2014-10-29" version="1">MLTEEHRETSSSLFTTLSTTTQAFRVGGTVSNDILLTDTVGFISRLPTYMIDAFKSTLEESLTAALVLLLIDASEDMRSIRIKYITCMNILKELKANGSKVLVVFTKCDKVMGSEEAISQIADDLGVQDAMAISAKTGYGIHKLKSIIVQLSSRKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSZ6</accession>
    <name>A0A075MSZ6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Haloacid dehalogenase superfamily enzyme, subfamily IA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NTE_02658</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HAD-like hydrolase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226986991.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSZ6"/>
    <dbReference type="STRING" id="1459636.NTE_02658"/>
    <dbReference type="GeneID" id="41598350"/>
    <dbReference type="KEGG" id="nev:NTE_02658"/>
    <dbReference type="eggNOG" id="arCOG02291">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_8_3_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044281">
        <property type="term" value="P:small molecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051400">
        <property type="entry name" value="HAD-like_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46470:SF2">
        <property type="entry name" value="GLYCERALDEHYDE 3-PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46470">
        <property type="entry name" value="N-ACYLNEURAMINATE-9-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF84701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="239" mass="27061" checksum="C9F950F71C5C0539" modified="2014-10-29" version="1">MHRQQPFVFFDLGQTLVTEWDFINHFDGKFLELLNGYGARIDMRNYRAVRDSMIRDRRIGHGSVKELVIEICRAVLPSGYENAILQKIDPQVKAGRRELFRFADGAEQVLKELSQGKKCDLGIIANQSEDIVALLQGAGLDKYFKVTAISGAIKMKKPDPRIFQLALKQAGREAQECVMVGDRLDTDVCPANRLGMTTMRITDSLFALQQPREDCERPDYTIAKLTEVPATVEKIISRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MT21</accession>
    <name>A0A075MT21_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00387</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699435.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MT21"/>
    <dbReference type="GeneID" id="41596270"/>
    <dbReference type="KEGG" id="nev:NTE_00387"/>
    <dbReference type="HOGENOM" id="CLU_1870623_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="136" mass="14028" checksum="9F111B44DA61B960" modified="2014-10-29" version="1">MNSVRDGRFKSVARTFTGAHKTSVNGKAAAPVVGLLLLGMLATSLLSFSTNSALAATSSSSSSSLVGDSSRDAFQLAVTPIAPKLPADGNDYLIMVQLQTAKDGKPREAPYDIDVTLLTSDNTVASPQGKVTIKTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MT31</accession>
    <name>A0A075MT31_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01898</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700627.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MT31"/>
    <dbReference type="GeneID" id="41597648"/>
    <dbReference type="KEGG" id="nev:NTE_01898"/>
    <dbReference type="HOGENOM" id="CLU_084395_0_0_2"/>
    <dbReference type="OrthoDB" id="12176at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13412">
        <property type="entry name" value="HTH_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="227" mass="25163" checksum="008F8D1368FF6734" modified="2014-10-29" version="1">MTNLGQDAPIVKTTTTHARNVSRQAIVAELENIGVNASLFESLTIDQLSDLLYNLNKVIINSNGNPMNSQRTKGVILSAVDRKILKALLECGGNPSSLQLSRELDIPLSTVQRRRKRLEEEFISESYGLRYEKFGKRHITFIVSLGVGDRSEVTKEILVLEKVSALTRTFGDGADLKVEAILDSNQEFIEISEKIKSISGIQKISWFESIEVVGRKKETDLSIIGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MT51</accession>
    <name>A0A075MT51_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SSU ribosomal protein S26E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_01923</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MT51"/>
    <dbReference type="STRING" id="1459636.NTE_01923"/>
    <dbReference type="KEGG" id="nev:NTE_01923"/>
    <dbReference type="eggNOG" id="arCOG04305">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129451_3_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1740.20">
        <property type="entry name" value="Ribosomal protein S26e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000892">
        <property type="entry name" value="Ribosomal_eS26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038551">
        <property type="entry name" value="Ribosomal_eS26_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006816">
        <property type="entry name" value="PRK09335.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12538">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12538:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01283">
        <property type="entry name" value="Ribosomal_S26e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF83982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="100" mass="10821" checksum="6412A18CCC20C57B" modified="2014-10-29" version="1">MPIPPMPKKRASRGRSKGGKGSSGVVHCSQCGALVPRDKAKKVTGRITLVEPTLAKELKAQGAYIPMSTDVKFYCVSCAVHRGIVKVRSEAERRTGGRLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MT80</accession>
    <name>A0A075MT80_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701272.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MT80"/>
    <dbReference type="GeneID" id="41598404"/>
    <dbReference type="KEGG" id="nev:NTE_02714"/>
    <dbReference type="eggNOG" id="arCOG03788">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1607211_0_0_2"/>
    <dbReference type="OrthoDB" id="10027at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117070">
        <property type="entry name" value="LEA14-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="164" mass="17860" checksum="9C0146968496E4B9" modified="2014-10-29" version="1">MLIGPRRALLIGVIAAVAATIILVPIIFTLNAPDFNQIGVRLSNVTIADSTEQSMEIKPIFTIMNPTDVTITTSKVDYELFADGVSLGSHTLSYEDVPLNGRPAIFSGMSVPVPDSFTLQFDDKVADIYNKIKDNPDSIKWRASGTAQIESTLTIATRDFNNEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MT82</accession>
    <name>A0A075MT82_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ferredoxin--NADP(+) reductase</fullName>
            <ecNumber evidence="2">1.18.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_02274</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ferredoxin--NADP reductase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.18.1.2" evidence="2"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700923.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MT82"/>
    <dbReference type="STRING" id="1459636.NTE_02274"/>
    <dbReference type="GeneID" id="41597989"/>
    <dbReference type="KEGG" id="nev:NTE_02274"/>
    <dbReference type="eggNOG" id="arCOG02200">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1006919_0_0_2"/>
    <dbReference type="OrthoDB" id="35401at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004324">
        <property type="term" value="F:ferredoxin-NADP+ reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06195">
        <property type="entry name" value="FNR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033892">
        <property type="entry name" value="FNR_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051930">
        <property type="entry name" value="FNR_type-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47878">
        <property type="entry name" value="OXIDOREDUCTASE FAD/NAD(P)-BINDING DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47878:SF2">
        <property type="entry name" value="OXIDOREDUCTASE FAD_NAD(P)-BINDING DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF84328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="280" mass="31953" checksum="C72D0340CD080EF5" modified="2014-10-29" version="1">MVVDNKGKITYLQVIKEDLAVFRITPENGQIPDFKAGQFLTIGTHVPSEGKIIRRAYSIASPPEQKKCWELYIRWVRKPVPGRLTTQLFNMKEGDEISWVRPTGIFTINEKMHDGSPDNRRMVLIGGGTGLAPFVSYSMHLHATQSKREIVVLHGASYVDELGYRELLTALEDESLDKGKDKWNFRYRASVSRPQEWFNRTWNGQKGRVESFLRPKAGKDLSPLEELVGEKVTPENTSFYICGWQGTVDGALDYLIPKGFVTERNKRKDGSYDIKFESYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MT89</accession>
    <name>A0A075MT89_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CAAX protease self-immunity</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_02724</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701282.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MT89"/>
    <dbReference type="STRING" id="1459636.NTE_02724"/>
    <dbReference type="GeneID" id="41598414"/>
    <dbReference type="KEGG" id="nev:NTE_02724"/>
    <dbReference type="HOGENOM" id="CLU_1307858_0_0_2"/>
    <dbReference type="OrthoDB" id="8232at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004175">
        <property type="term" value="F:endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080120">
        <property type="term" value="P:CAAX-box protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1/LyrA-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="CAAX prenyl protease 2/Lysostaphin resistance protein A-like" evidence="2">
        <location>
            <begin position="68"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF84766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="215" mass="23948" checksum="55037CCCE3D4457A" modified="2014-10-29" version="1">MAEAKRGRFADEKADFNPRTWLTKYRRNSIGYLVKMLLFYHGIGVGLLVAGTLILEQIIPGYQEPDIPRSLIGVLSAGPLEETVFFGVPFYVFNSSHAVIVTGAMWAVLHIFNTPNIELASLAFGNWLFVIPSLFFSLRTWASGKGWFSVVVHSAWNGIFFAAGCWGGDINCTMLEPDPFTNFLMAGLSAALLAGTYVLYRWRKKREQAATGRIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTG0</accession>
    <name>A0A075MTG0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Plastocyanin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_02853</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148702171.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTG0"/>
    <dbReference type="STRING" id="1459636.NTE_02853"/>
    <dbReference type="GeneID" id="41598535"/>
    <dbReference type="KEGG" id="nev:NTE_02853"/>
    <dbReference type="eggNOG" id="arCOG02926">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG08033">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083799_0_0_2"/>
    <dbReference type="OrthoDB" id="4392at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000923">
        <property type="entry name" value="BlueCu_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052721">
        <property type="entry name" value="ET_Amicyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027560">
        <property type="entry name" value="PEFG-CTERM"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04296">
        <property type="entry name" value="PEFG-CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36507">
        <property type="entry name" value="BLL1555 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36507:SF1">
        <property type="entry name" value="BLL1555 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00127">
        <property type="entry name" value="Copper-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Blue (type 1) copper" evidence="4">
        <location>
            <begin position="46"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF84891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="289" mass="28919" checksum="74559B0B75C53848" modified="2014-10-29" version="1">MNAKIALAVGMTAILAAVLAIPSQAAFAATVNITIVPGASTKTNDAFSPNPAQANVGDTVIWTNKDGALHTVNSGTGGTADKKFGLKEDGSPVLIPPSKTFEWKATEAGDYPYFCSLHPAMVGDLKVAAAGSGGGATTGGNTTTGGNATGGGNATMQQGTATAQLDGKSYTVTSKSATSKVTTATITAGKSVNVAFDKAGEMELTLPKAMISGIQSVTANGQTVQFTSTNSTDSTTIKFTAPTGATSVDITGTMVVPEFGVIAALVLAVSLVAVIGVARFKGQAFGFRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTI0</accession>
    <name>A0A075MTI0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Purine-cytosine permease-like transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NTE_02035</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700732.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTI0"/>
    <dbReference type="STRING" id="1459636.NTE_02035"/>
    <dbReference type="GeneID" id="41597776"/>
    <dbReference type="KEGG" id="nev:NTE_02035"/>
    <dbReference type="eggNOG" id="arCOG03447">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048240_1_1_2"/>
    <dbReference type="OrthoDB" id="27121at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015209">
        <property type="term" value="F:cytosine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030191">
        <property type="entry name" value="CodB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30569:SF0">
        <property type="entry name" value="CYTOSINE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30569">
        <property type="entry name" value="CYTOSINE TRANSPORTER CODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="305"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="370"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="400"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF84092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="431" mass="45941" checksum="864224E8E30FCEB5" modified="2014-10-29" version="1">MAIIRAPEWGITPISEKGRRLGGLDYFILWSSLGVGLLVLSAGSFLSSASFVDATLAIVAGSVGGSVLLALAGKIGSDHGVTSLVSMRPAFGIRGSYLPAILNVMQLVGWTTFEIMIMARAAALLSGNAIPYPALAAAFGAVVALLGIAGPLAVARQWLGKFAVWIAYGTSGIIIVTLLMAPGAHDIITSQGKGMSFFTALDLVIAMPISWMPLVADYNRFAKKSRTAFWATLIGFALTNMMFYFGGVLLGTFDVLAIIVAMQAIFFGFLMLLLLVDEADNAFADLYSAAVSVQDILPRLSQKHLIIGFTAFSTVLATVVTIQDYETFLLLIGAIFVPLFGVVLTDYYLVKRQKYTEGMMFGISNKGIAWPAVAAWAIGALLNFVMSPLSPLYVPSMPTIGATMPSFAAASLAYLAIVRFMQRRPKAELAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTL7</accession>
    <name>A0A075MTL7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02486</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701092.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTL7"/>
    <dbReference type="GeneID" id="41598190"/>
    <dbReference type="KEGG" id="nev:NTE_02486"/>
    <dbReference type="HOGENOM" id="CLU_2679063_0_0_2"/>
    <dbReference type="OrthoDB" id="10975at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="74" mass="8042" checksum="161C09D143188B26" modified="2014-10-29" version="1">MVEKSGSNIPGPDLYVWPLVAGKMATEMAIMASVSFARIVQIAAQSADTALGKYIELAEQEMQKAQRKESVKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTL8</accession>
    <name>A0A075MTL8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02929</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701449.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTL8"/>
    <dbReference type="GeneID" id="41598607"/>
    <dbReference type="KEGG" id="nev:NTE_02929"/>
    <dbReference type="eggNOG" id="arCOG08812">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1607074_0_0_2"/>
    <dbReference type="OrthoDB" id="4392at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="165" mass="17079" checksum="550F6CB7A13361B7" modified="2014-10-29" version="1">MEGTKKRITVLLSSTILAAGLVVVVAIGSGFSGALATTMTATPSAPPVNLKTDNESVDITVDWSPQEIQQGSATEFSINFQDPSSGASLEHVNYNLEVKDADGNTVESLTDLHSHTGKDTQTVTFDNSGDFQLAITVIGTGLTMPFDTSKSGTAETPITVAAGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTS4</accession>
    <name>A0A075MTS4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02112</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTS4"/>
    <dbReference type="STRING" id="1459636.NTE_02112"/>
    <dbReference type="KEGG" id="nev:NTE_02112"/>
    <dbReference type="HOGENOM" id="CLU_1965442_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="127" mass="14900" checksum="6B69A29D2C0C56ED" modified="2014-10-29" version="1">MLRKTIQLVLPIQIQVSMTTEDERREIYYLRLLVIVKEGAKGKYFEVRGEKKWSYSADIASQFEKKYNEYTSARTVAMNMRYLQSKGLVVSTKSRDGKRTLWAIEQKADFELNHSGNLDDHRESIEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTV1</accession>
    <name>A0A075MTV1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Secondary thiamine-phosphate synthase enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00619</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699618.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTV1"/>
    <dbReference type="STRING" id="1459636.NTE_00619"/>
    <dbReference type="GeneID" id="41596482"/>
    <dbReference type="KEGG" id="nev:NTE_00619"/>
    <dbReference type="eggNOG" id="arCOG04214">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096980_1_2_2"/>
    <dbReference type="OrthoDB" id="6663at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.460">
        <property type="entry name" value="YjbQ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001602">
        <property type="entry name" value="UPF0047_YjbQ-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035917">
        <property type="entry name" value="YjbQ-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00149">
        <property type="entry name" value="TIGR00149_YjbQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30615">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YJBQ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30615:SF2">
        <property type="entry name" value="YJBQ FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01894">
        <property type="entry name" value="YjbQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004681">
        <property type="entry name" value="UCP004681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111038">
        <property type="entry name" value="YjbQ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="138" mass="15675" checksum="AE280CDB174CBBCD" modified="2014-10-29" version="1">MKSKTAYLTFNTPKRHAFVNITPQVRKVVEESGVKEGMVLINAMHISASVFINDDESGLHQDFEKWLEKLAPYSPESYLHNRTGEDNADAHLKRQVMGREVVVAITAGKLDFGPWEQIFYGEFDGQRPKRVLVKVIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTV9</accession>
    <name>A0A075MTV9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Deoxyhypusine synthase</fullName>
            <ecNumber evidence="3">2.5.1.46</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_03041</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the deoxyhypusine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.46" evidence="3"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701541.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTV9"/>
    <dbReference type="STRING" id="1459636.NTE_03041"/>
    <dbReference type="GeneID" id="41598710"/>
    <dbReference type="KEGG" id="nev:NTE_03041"/>
    <dbReference type="eggNOG" id="arCOG04142">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039781_1_0_2"/>
    <dbReference type="OrthoDB" id="17730at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034038">
        <property type="term" value="F:deoxyhypusine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.910.10:FF:000010">
        <property type="entry name" value="Deoxyhypusine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.910.10">
        <property type="entry name" value="Deoxyhypusine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002773">
        <property type="entry name" value="Deoxyhypusine_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036982">
        <property type="entry name" value="Deoxyhypusine_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002294">
        <property type="entry name" value="PRK01221.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703">
        <property type="entry name" value="DEOXYHYPUSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703:SF0">
        <property type="entry name" value="DEOXYHYPUSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01916">
        <property type="entry name" value="DS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF85076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="325" mass="35864" checksum="C4CF12FADF845335" modified="2014-10-29" version="1">MASKTKKSRDDLLHSAVKDHAISKDSDVNSIFTSMASSGGFESRNLSDGVDILKRMIVDEPQCTKFLSFVAALMSTGARGIVRDMLKNRMFDVVITTCGALDHDIARSYDKYYAGDFRMDDTTLLKKKVHRLGNVLVPMTAYGPLIEEKVQECLSGMYKAGHRDVSTYEIADYIGSTLDESSFLYWAHKNKIPVIVPGIVDGAVGSQIWLFNQQHKDFKLNLLKDETKLSDMVFDAKKSGAFMIGGGISKHHTLWWNQYRGGLDYAVYITTAPEWDGSLSGALVAEAISWGKVTTKARQTTIHGEASTLLPFIYAAIAAAAAARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MU16</accession>
    <name>A0A075MU16_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative nucleic acid-binding protein, contains PIN domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_00684</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699669.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MU16"/>
    <dbReference type="STRING" id="1459636.NTE_00684"/>
    <dbReference type="GeneID" id="41596541"/>
    <dbReference type="KEGG" id="nev:NTE_00684"/>
    <dbReference type="HOGENOM" id="CLU_121774_5_0_2"/>
    <dbReference type="OrthoDB" id="168412at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd09873">
        <property type="entry name" value="PIN_Pae0151-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044153">
        <property type="entry name" value="PIN_Pae0151-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051619">
        <property type="entry name" value="TypeII_TA_RNase_PINc/VapC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35901:SF1">
        <property type="entry name" value="EXONUCLEASE VAPC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35901">
        <property type="entry name" value="RIBONUCLEASE VAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIN" evidence="2">
        <location>
            <begin position="8"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF82764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="151" mass="17280" checksum="3D7FD489B712EBA6" modified="2014-10-29" version="1">MTKKDSFLFDTSSLLYILKAKQYQRLSKKCHILDLTFYEYGNAVLNILGKRNVKDSSPRPSAEEGTKLLLHAYEKIAEQITILTYQCNPALLLDIFELAKKENLTFYDASYLHYCLIHNLSFVTEDKQLAAAAIRNSIDAMDADRWTTTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MU19</accession>
    <name>A0A075MU19_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00694</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MU19"/>
    <dbReference type="KEGG" id="nev:NTE_00694"/>
    <dbReference type="HOGENOM" id="CLU_1478848_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="182" mass="20219" checksum="6B9942EF07E41E01" modified="2014-10-29" version="1">MVLGMKRTISYITLAVVLGLVSNSAITSLAFGQEEPQQTHTWIFVTGPAKYCDENTQVLSDYISSATAYLAYIGRHDIVCFPSAGDVMNVRDNVELIRTLYPDDKMVFTYDLRNPAKDRDFKLFLGTVDSFNHKNSLGKAFISEGWAVSAFSGEVAAHELAHLTTHKDHPPGTDMNDPATWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MU49</accession>
    <name>A0A075MU49_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_02188</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700853.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MU49"/>
    <dbReference type="STRING" id="1459636.NTE_02188"/>
    <dbReference type="GeneID" id="41597910"/>
    <dbReference type="KEGG" id="nev:NTE_02188"/>
    <dbReference type="eggNOG" id="arCOG04362">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062767_3_0_2"/>
    <dbReference type="OrthoDB" id="11410at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057527">
        <property type="entry name" value="HVO_A0261-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25213">
        <property type="entry name" value="HVO_A0261_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HVO-A0261-like N-terminal" evidence="2">
        <location>
            <begin position="20"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="35"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF84242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="276" mass="32175" checksum="127F34A6D6B2033D" modified="2014-10-29" version="1">MPPAQDEDLVSAYANTEKTFFELASEQRLSILFRLNEKKAKISQLAKDLNITMQEAHRNVNRLQDAGLIEKDPEGIFSLTTFGNTIIKQIPTFNYLSKHKEYFSEHILGELPFKFIMRLGALDQCEFIKGVVAILERWKDIYRESDEYIYEIVPQVPIDLIEPALSRVKEKGVKYSYVLPKNVIIPKGRKDLLKKLGHSELLTKGAIERRMVDRVQVAVILNEKQAAVMFPTQKGETDMNMIFFSTDPLFHEWCLDYFRYRWYGSDIFDESHLKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MU72</accession>
    <name>A0A075MU72_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC-type transport system involved in Fe-S cluster assembly, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_02650</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron-sulfur cluster assembly SufBD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701219.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MU72"/>
    <dbReference type="STRING" id="1459636.NTE_02650"/>
    <dbReference type="GeneID" id="41598342"/>
    <dbReference type="KEGG" id="nev:NTE_02650"/>
    <dbReference type="eggNOG" id="arCOG01715">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026231_3_1_2"/>
    <dbReference type="OrthoDB" id="300624at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055346">
        <property type="entry name" value="Fe-S_cluster_assembly_SufBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000825">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037284">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045595">
        <property type="entry name" value="SufBD_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30508">
        <property type="entry name" value="FES CLUSTER ASSEMBLY PROTEIN SUF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30508:SF1">
        <property type="entry name" value="UPF0051 PROTEIN ABCI8, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01458">
        <property type="entry name" value="SUFBD_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19295">
        <property type="entry name" value="SufBD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101960">
        <property type="entry name" value="Stabilizer of iron transporter SufD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUF system FeS cluster assembly SufBD N-terminal" evidence="3">
        <location>
            <begin position="99"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="SUF system FeS cluster assembly SufBD core" evidence="2">
        <location>
            <begin position="179"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00043967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF84693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="474" mass="52330" checksum="83B6008DB6308D54" modified="2014-10-29" version="1">MPTTLANINASNVIDEVSPKDPAWLAEERKKAIAKYLSLPNEVSPLYSKYSDANRIKPQGVHLNFGQGNSRHVLSSDLAKRLEELEKETGILQVGPEINKVVIKENVAKQGVIVTGIKDAISRHADLVKAHIEANPLDHGEDKFLALEAAAFQSGVFVYVPRNVVLEEPIRIITSLADDGTSLVSRNIFAVEQGAKATVVQELYAPGTGNAAETQQGYFELIETSVKPNAHLEAVTLQAMGTDTVCVSNRKAFVERDGKMSWYVGLFGTMLSRFKTDSVMKGQGASAEDVEIVFGVGNQSFDIMSNLIHNGQFSRGKVQVKSVMKDTSKSLFKGMIKIGKDGKGTESYLAGHAILLDKGAKSDSIPGLEILTNEVRATHSASVAQIDENQIFYLTTRGLSREGAKREIVSGFLEPLSRKMGPTIRAWINYLIENKWQGNPLMLRADEAMEQILEVEKSRYRETQDIFEKHYKYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUB2</accession>
    <name>A0A075MUB2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NTE_02728</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the HerA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701286.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUB2"/>
    <dbReference type="STRING" id="1459636.NTE_02728"/>
    <dbReference type="GeneID" id="41598418"/>
    <dbReference type="KEGG" id="nev:NTE_02728"/>
    <dbReference type="eggNOG" id="arCOG00280">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_571898_0_0_2"/>
    <dbReference type="OrthoDB" id="6931at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008571">
        <property type="entry name" value="HerA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002789">
        <property type="entry name" value="HerA_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42957">
        <property type="entry name" value="HELICASE MJ1565-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42957:SF1">
        <property type="entry name" value="HELICASE MJ1565-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01935">
        <property type="entry name" value="DUF87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase HerA central" evidence="5">
        <location>
            <begin position="167"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00048954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF84770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="478" mass="53490" checksum="FD56F1A57897EA66" modified="2014-10-29" version="1">MKILSKNGNELLLLAMKDDSAAKGDYLLIEDRGRSMVVQVYDEEYLSSQALVEDIVKEEVVNATSAENLHDPLNIGSLSRLVRDARIFKAKIRAAVADGRLASDVTWLPSRVESRIRRLKAKELDALLGRSGVYPIPLGRAGDNEDFEIFAEDLDGKLTIITGKKESGKSHLSKLLVKTLVQHGAFVVVFDLNNEYSGLRWNRDGTPSQVHDRVMVLEPGKGLQFSLDYCGKAAVAGMLKNALDIPAASMREFFRIWDWLENKRTLGIEAIGNAINTWNINELVRDALVSRYHSIQQSRLFTDNGNAGFRFEEAMKSGGAAMVINMGESSGTTRRMTVELVLSKIVDLLERKAIPPIFLFAEEAHLYIRETYWEDLITRMRHFGVYTTFVTNQPDAINDGIYRQVDNIFLFNFTNDSDLDKIAKVSLADSDTIRSIVRTLPQRQCLAIGKAVCDLPVVVKVAAAEVLALGETKRFFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUD5</accession>
    <name>A0A075MUD5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Plastocyanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701693.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUD5"/>
    <dbReference type="STRING" id="1459636.NTE_03232"/>
    <dbReference type="GeneID" id="41598887"/>
    <dbReference type="KEGG" id="nev:NTE_03232"/>
    <dbReference type="HOGENOM" id="CLU_088474_0_0_2"/>
    <dbReference type="OrthoDB" id="4392at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052721">
        <property type="entry name" value="ET_Amicyanin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36507">
        <property type="entry name" value="BLL1555 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36507:SF1">
        <property type="entry name" value="BLL1555 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="212" mass="22736" checksum="E04F19397015C8C9" modified="2014-10-29" version="1">MAVAGAASLTNASQEQFAQQQQDATKSPTSTSAATTVHAGSGGPVGPLTIFSPSRVEIKVGEKVVWTNPSLVSEPHTVTFMKDNSTFADFGSPFIVSKNTTFTPVSPGSNGEPFVVPNDNDTNIVVTLNKRSFFPVIINSEDKTSYLAPNAEYTMDGTEKYVNSGWIWPKDQAPQGVPPINQFAVTFTQAGTYNYVCLVHPWMKGQVVVAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUE2</accession>
    <name>A0A075MUE2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701702.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUE2"/>
    <dbReference type="STRING" id="1459636.NTE_03242"/>
    <dbReference type="GeneID" id="41598897"/>
    <dbReference type="KEGG" id="nev:NTE_03242"/>
    <dbReference type="HOGENOM" id="CLU_202282_0_0_2"/>
    <dbReference type="OrthoDB" id="379897at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="69" mass="8288" checksum="E53847D6976DA1F8" modified="2014-10-29" version="1">MKVELEMYINEDDESAVMNKVSEITKHVKELGFKIGELEFKNKEEGEDNHHRYKGKEKGKEDKKRRRHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUE9</accession>
    <name>A0A075MUE9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cobalt transporter subunit (CbtA)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02784</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701334.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUE9"/>
    <dbReference type="STRING" id="1459636.NTE_02784"/>
    <dbReference type="GeneID" id="41598473"/>
    <dbReference type="KEGG" id="nev:NTE_02784"/>
    <dbReference type="eggNOG" id="arCOG06353">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090632_0_0_2"/>
    <dbReference type="OrthoDB" id="382153at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012666">
        <property type="entry name" value="CbtA_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09490">
        <property type="entry name" value="CbtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="234" mass="24511" checksum="838F71E29C38230E" modified="2014-10-29" version="1">MQAQRAFFLAIIAGIIGGAIAVAINFVVVQARQSEIANFYTDEFVAPSIIDEGEFDQKLQELQIQNVALPIAIGVGGGVLVAAVYLRVGAGAFKVAVAVAGAAWLALYVMPAVKYPANSDTAFNPEGDGGYSMLYAGYMAASGLAALGSAIAFSKTKRKNWYVGAAGLYIGIIAALYVSFPAFSGLEFVPQQLLAGWRSSMAAGMTALWFALGIIAGALLEREEKKEKGVEKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUF3</accession>
    <name>A0A075MUF3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03262</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701722.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUF3"/>
    <dbReference type="GeneID" id="41598917"/>
    <dbReference type="KEGG" id="nev:NTE_03262"/>
    <dbReference type="HOGENOM" id="CLU_2893379_0_0_2"/>
    <dbReference type="OrthoDB" id="384067at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="66" mass="7100" checksum="86799027B51AC7C8" modified="2014-10-29" version="1">MPAAPVFVINPAFIQSLFDAQQQNSMLLNQIQMDDMSLIAVGLVIGLIIIVVVALMSMVGGLHVFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUH4</accession>
    <name>A0A075MUH4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Iron (Metal) dependent repressor, DtxR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NTE_02294</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DtxR/MntR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUH4"/>
    <dbReference type="STRING" id="1459636.NTE_02294"/>
    <dbReference type="KEGG" id="nev:NTE_02294"/>
    <dbReference type="eggNOG" id="arCOG02100">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069532_3_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000189">
        <property type="entry name" value="HTH-type transcriptional regulator MntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.10">
        <property type="entry name" value="Iron dependent repressor, metal binding and dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050536">
        <property type="entry name" value="DtxR_MntR_Metal-Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001367">
        <property type="entry name" value="Fe_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036421">
        <property type="entry name" value="Fe_dep_repressor_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022687">
        <property type="entry name" value="HTH_DTXR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022689">
        <property type="entry name" value="Iron_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003025">
        <property type="entry name" value="PRK03902.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33238">
        <property type="entry name" value="IRON (METAL) DEPENDENT REPRESSOR, DTXR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33238:SF7">
        <property type="entry name" value="IRON-DEPENDENT TRANSCRIPTIONAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02742">
        <property type="entry name" value="Fe_dep_repr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01325">
        <property type="entry name" value="Fe_dep_repress"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00529">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47979">
        <property type="entry name" value="Iron-dependent repressor protein, dimerization domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50944">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH dtxR-type" evidence="5">
        <location>
            <begin position="27"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF84347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="152" mass="17387" checksum="756C9AF0A0886E62" modified="2014-10-29" version="1">MARKKTDQKGDRLESIRDAHNAEKMARTTRMEDYLEVIYELIQHKGYATTVDISNYLNVSSPSVTKMLQRLSESGHVNYEKYRGITLTEAGVAVAKNMHDRHGVLAEFLMMIGVDEDTANRDAEGIEHHLHPETLKKLEEFVKLAKNQGLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUI7</accession>
    <name>A0A075MUI7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA/RNA-binding protein Alba</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">albA</name>
        <name evidence="8" type="ORF">NTE_02304</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds double-stranded DNA tightly but without sequence specificity. Involved in DNA compaction.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="5">Acetylated. Acetylation at Lys-30 decreases DNA-binding affinity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the histone-like Alba family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700941.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUI7"/>
    <dbReference type="STRING" id="1459636.NTE_02304"/>
    <dbReference type="GeneID" id="41598019"/>
    <dbReference type="KEGG" id="nev:NTE_02304"/>
    <dbReference type="eggNOG" id="arCOG01753">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110989_1_1_2"/>
    <dbReference type="OrthoDB" id="10360at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.20">
        <property type="entry name" value="Alba-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01122">
        <property type="entry name" value="AlbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036882">
        <property type="entry name" value="Alba-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013795">
        <property type="entry name" value="DNA/RNA-bd_Alba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002775">
        <property type="entry name" value="DNA/RNA-bd_Alba-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01918">
        <property type="entry name" value="Alba"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82704">
        <property type="entry name" value="AlbA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="2 5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="3 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA/RNA-binding protein Alba-like" evidence="7">
        <location>
            <begin position="25"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="5">
        <location>
            <position position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF84357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="110" mass="11900" checksum="632B578B58663E8C" modified="2014-10-29" version="1">MSEAQPSTPQDSSAPQGSRDGPHDTIYIGKKPLMAYVTSTLIQLANQPKVTIKARGLSIGRAVDVSQITIKRMESAGYKIGDVRIGSETVKSEDGRTRNVSTIEIEIRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUJ8</accession>
    <name>A0A075MUJ8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein involved in tolerance to divalent cations</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02314</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CutA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700950.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUJ8"/>
    <dbReference type="STRING" id="1459636.NTE_02314"/>
    <dbReference type="GeneID" id="41598030"/>
    <dbReference type="KEGG" id="nev:NTE_02314"/>
    <dbReference type="eggNOG" id="arCOG04231">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098807_3_1_2"/>
    <dbReference type="OrthoDB" id="8015at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010038">
        <property type="term" value="P:response to metal ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053426">
        <property type="entry name" value="CutA_tolerance"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004323">
        <property type="entry name" value="Ion_tolerance_CutA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041095">
        <property type="entry name" value="dival_cat_tol_CutA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23419">
        <property type="entry name" value="DIVALENT CATION TOLERANCE CUTA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23419:SF8">
        <property type="entry name" value="FI09726P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03091">
        <property type="entry name" value="CutA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="GlnB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="120" mass="13297" checksum="F79CD982051AEC74" modified="2014-10-29" version="1">MSKAKAVIVISTFSTEESAAEIGKKLVEKGLCACVNFAKIRSIYSWKGKLEDQPEYIAFFKVAKGSAKALKQELARVHPYDVPEIVEIKMSDVSKPYLSWLADAGSAHRVAKKRNHSAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUK8</accession>
    <name>A0A075MUK8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PepSY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00918</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUK8"/>
    <dbReference type="KEGG" id="nev:NTE_00918"/>
    <dbReference type="HOGENOM" id="CLU_1222565_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="242" mass="24659" checksum="CB9F279740F7384F" modified="2014-10-29" version="1">MITATFGIMSSLTGSKTVFSLSLLVMGFAVASSVMIVPAAFAQNTTSPGGNQTMPGGNQTTPGGNSTQPVAFPGSNSIVNVQLNGNQTMTPEQGAQMPGQMNGSINVKQAIKDFLTDNLNVTLGDAIATAEAQVANGTTVAAHLDVVQGFLVYRVIVVDINNEIIHNVIVDAGNGSVLASQAISLAELAAMHGGMMMGPHGGMFGGGGPGSQMMMQPPPEMMQPPSGNETSEGPMMGMGFQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUS2</accession>
    <name>A0A075MUS2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">Citrate synthase</fullName>
            <ecNumber evidence="6">2.3.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NTE_02917</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>oxaloacetate + acetyl-CoA + H2O = citrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16845"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism; tricarboxylic acid cycle.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 8">Belongs to the citrate synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.16" evidence="6"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701439.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUS2"/>
    <dbReference type="STRING" id="1459636.NTE_02917"/>
    <dbReference type="GeneID" id="41598595"/>
    <dbReference type="KEGG" id="nev:NTE_02917"/>
    <dbReference type="eggNOG" id="arCOG04237">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025068_2_1_2"/>
    <dbReference type="OrthoDB" id="21302at2157"/>
    <dbReference type="UniPathway" id="UPA00223"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036440">
        <property type="term" value="F:citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="entry name" value="Citrate Synthase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011278">
        <property type="entry name" value="2-MeCitrate/Citrate_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024176">
        <property type="entry name" value="Citrate_synthase_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01800">
        <property type="entry name" value="cit_synth_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739:SF4">
        <property type="entry name" value="CITRATE SYNTHASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001369">
        <property type="entry name" value="Citrate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="active site" evidence="7">
        <location>
            <position position="259"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001369-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF84955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="394" mass="43881" checksum="E6FB9DBB06D55FCC" modified="2014-10-29" version="1">MDARNIGLRNIEVADTKICSIDGENGKLIYRGFDILDLVNHSTFEETSYLLLFGELPSPEQLTDFGRRLREARGIPEPMIKSMKNRPKRAQPMDVLQSCVAELADYDLNIDDFSKEAHTRRAITLIAKIPSIVAAWNRVRTGQHVVDPMEEGSHAANFLYMLRGVEPSAEEAKVMDICFILHAEHSFNASTFAAREISSTRASMYAAISGAVGALSGELHGGANVQVMKMLLEIGDPANVEKWVASRLSSGGRIMGMGHAVYRTTDPRADILSRLSKAISKEKNNKWFEITERAEKATKKWMLENKGQAIYPNVDLYSASIYYSMGIPMDLNTPIFAISRISGWASHVIEEKFAEAAPKPALYRPKAVYIGRYCGPMGCEYVPLSERKQQQQVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUX7</accession>
    <name>A0A075MUX7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02932</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701451.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUX7"/>
    <dbReference type="STRING" id="1459636.NTE_02932"/>
    <dbReference type="GeneID" id="41598610"/>
    <dbReference type="KEGG" id="nev:NTE_02932"/>
    <dbReference type="HOGENOM" id="CLU_2304331_0_0_2"/>
    <dbReference type="OrthoDB" id="383523at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="99" mass="11283" checksum="6040B53A30E5EF35" modified="2014-10-29" version="1">MPVVMIMTWEGVKKEDYEALRKTVNWEGNVPQGAMFHVSAFDGKGIRVTDVWENEQDFKKFVDSRLMPEAKKMGLKSEPKVEILPVHAVFAPAYKRAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUZ6</accession>
    <name>A0A075MUZ6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hydrolase or acyltransferase of alpha/beta superfamily</fullName>
            <ecNumber evidence="2">3.1.1.24</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03453</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.1.24" evidence="2"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUZ6"/>
    <dbReference type="STRING" id="1459636.NTE_03453"/>
    <dbReference type="KEGG" id="nev:NTE_03453"/>
    <dbReference type="eggNOG" id="arCOG01648">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG07416">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_13_3_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047570">
        <property type="term" value="F:3-oxoadipate enol-lactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="24"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="275" mass="30945" checksum="77E388EA577EFB3E" modified="2014-10-29" version="1">MPYLQIAPHSINLYYEDHGHLDSYPLILIHPIGGNVLIWEYEISLLLKNGFRIIAYEIRGHHRTNMGKSNAYAMQDLADDLGALLTHLDIRRCTIIGHSIGGIIGSIYAAQNPEKVDGLVLINSSPKKFQDFDLEKHFKTRAIAITRGIEALAEHKLKSFDEFKDLAKEKRYSDFFKNVFTKTSVGGFVAATVALYSIPEDAARKLRMSGCRVLAIVGSDDSAFIRLSKETKEMMPEMELKVIEGSDHWVIIEKPKEMYDILMGFLGKIIGVSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MV61</accession>
    <name>A0A075MV61_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protoheme IX farnesyltransferase</fullName>
            <ecNumber evidence="11">2.5.1.141</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Heme B farnesyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Heme O synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ctaB</name>
        <name evidence="12" type="ORF">NTE_03111</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>heme b + (2E,6E)-farnesyl diphosphate + H2O = Fe(II)-heme o + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:28070"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:60530"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.141"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Porphyrin-containing compound metabolism; heme O biosynthesis; heme O from protoheme: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Cell membrane</location>
            <topology evidence="2 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="11">Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.141" evidence="11"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MV61"/>
    <dbReference type="STRING" id="1459636.NTE_03111"/>
    <dbReference type="KEGG" id="nev:NTE_03111"/>
    <dbReference type="eggNOG" id="arCOG00479">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029631_0_1_2"/>
    <dbReference type="UniPathway" id="UPA00834">
        <property type="reaction ID" value="UER00712"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008495">
        <property type="term" value="F:protoheme IX farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048034">
        <property type="term" value="P:heme O biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13957">
        <property type="entry name" value="PT_UbiA_Cox10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00154">
        <property type="entry name" value="CyoE_CtaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006369">
        <property type="entry name" value="Protohaem_IX_farnesylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01473">
        <property type="entry name" value="cyoE_ctaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003349">
        <property type="entry name" value="PRK04375.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448">
        <property type="entry name" value="PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448:SF2">
        <property type="entry name" value="PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 11" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIF85145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="301" mass="33225" checksum="7FEA4209375B3760" modified="2014-10-29" version="1">MDTVRQVSVGSKIKDYYEVTKPKIWYLLVFTTFGAALTASFYFDIPIEPMTWVLLIGGVTAGSAAAETLTGYIDRDIDAMMDRTKDRPIPSGRISPKNALAFGLILTAISLVMSWFVNIWAFSLMAFGLFDNVIVYSKWLKRRSQSNIILGGFSGGAPALIGYVAVTTQNLEIGLVMAGLVFLWIPTHIWSLALHIKKDYTKASVPMLPVVSSEKSSVRVIAGTTVMMVVFSLVPFFFGEFGLIYLTTAGVFGAVMLALSMWLLVKPTEKASWTVFKFSSPYLTALFIAFMVDAYYFKPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVA1</accession>
    <name>A0A075MVA1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVA1"/>
    <dbReference type="STRING" id="1459636.NTE_02540"/>
    <dbReference type="KEGG" id="nev:NTE_02540"/>
    <dbReference type="HOGENOM" id="CLU_2392750_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="93" mass="10646" checksum="2D8795AB2606DF08" modified="2014-10-29" version="1">MIIERGVDFLEKMAGVQPKKPEQKQFGVYFSPEEIQLLEIYARELFNDGYISRNSIGSLCRFCTIAFLKNSQNQALENVRARQAAQTKESGQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVA8</accession>
    <name>A0A075MVA8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03064</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVA8"/>
    <dbReference type="STRING" id="1459636.NTE_03064"/>
    <dbReference type="KEGG" id="nev:NTE_03064"/>
    <dbReference type="HOGENOM" id="CLU_3147799_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="48" mass="5703" checksum="B5FD15E5B496FD62" modified="2014-10-29" version="1">MLRVSEAMVEKFVVQKEHVDGLSFAETIMRYHPLHDRRSSKRKTNDKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVD1</accession>
    <name>A0A075MVD1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03089</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701575.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVD1"/>
    <dbReference type="STRING" id="1459636.NTE_03089"/>
    <dbReference type="GeneID" id="41598751"/>
    <dbReference type="KEGG" id="nev:NTE_03089"/>
    <dbReference type="HOGENOM" id="CLU_2340015_0_0_2"/>
    <dbReference type="OrthoDB" id="10196at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="97" mass="11392" checksum="ADF2E2E8374AAF18" modified="2014-10-29" version="1">MPDNNNNNKKTVKFHGQEVEDVVVLYLQQVRDKPGTTAIEEFDAERDPQVCETINVQVVSEFVTITFYKDEKANSIVRRELIPTYRVEHIWVRDLQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVF0</accession>
    <name>A0A075MVF0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pantoate kinase</fullName>
            <shortName evidence="5">PoK</shortName>
            <ecNumber evidence="5">2.7.1.169</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NTE_02599</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(R)-pantoate + ATP = (R)-4-phosphopantoate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28246"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61294"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.169"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; coenzyme A biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the GHMP kinase family. PoK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.169" evidence="5"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701176.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVF0"/>
    <dbReference type="STRING" id="1459636.NTE_02599"/>
    <dbReference type="GeneID" id="41598292"/>
    <dbReference type="KEGG" id="nev:NTE_02599"/>
    <dbReference type="eggNOG" id="arCOG04263">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081191_0_0_2"/>
    <dbReference type="OrthoDB" id="85822at2157"/>
    <dbReference type="UniPathway" id="UPA00241"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02223">
        <property type="entry name" value="Pantoate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012043">
        <property type="entry name" value="PoK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42282:SF1">
        <property type="entry name" value="PANTOATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42282">
        <property type="entry name" value="PANTOATE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016896">
        <property type="entry name" value="GHMP_arc_MJ0969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="3 5 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="6">
        <location>
            <begin position="89"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF84642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="308" mass="32462" checksum="04F9508147A49728" modified="2014-10-29" version="1">MASTVVTAPVAVAKAFSPGHVTGFFEIPKLPSSGPQYRGSRGAGFSIDRGISTTVYVFDGKTGSKVLINGRTAKPKDAEVSQWVIDRYAKSAEKPFFVRVEHEIDIPVGFGLGSSGAAALSLSYALNAALGSKQSMQQAAQLAHEAEIACKTGLGTVIAEYAGGFEMRTGAGAPGIGTVEKISLEDNYKAVILCISPISTKAFLANRMDMINGLGGRMLDKLAETKSIDDFMKMSYQFADTLGLTEGKCRAPVRALRAAGIECSVALFGETVFTIVPEACTNEAADVLQKFEGTLLVCDIDGRGARVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVG5</accession>
    <name>A0A075MVG5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dienelactone hydrolase-like enzyme</fullName>
            <ecNumber evidence="3">3.1.1.45</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_03129</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.1.45" evidence="3"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701608.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVG5"/>
    <dbReference type="STRING" id="1459636.NTE_03129"/>
    <dbReference type="GeneID" id="41598789"/>
    <dbReference type="KEGG" id="nev:NTE_03129"/>
    <dbReference type="eggNOG" id="arCOG01659">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054590_7_0_2"/>
    <dbReference type="OrthoDB" id="12289at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008806">
        <property type="term" value="F:carboxymethylenebutenolidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051049">
        <property type="entry name" value="Dienelactone_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46623:SF6">
        <property type="entry name" value="ALPHA_BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46623">
        <property type="entry name" value="CARBOXYMETHYLENEBUTENOLIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="Dienelactone hydrolase" evidence="2">
        <location>
            <begin position="62"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF85163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="277" mass="29513" checksum="FC775B9F3AE233DD" modified="2014-10-29" version="1">MNSKSVAKIGGAAAIAAAIAIAVWIGTQKGDSVESNVTMLGDGKDVSKVETSMVQYYDNASGFLAKPAGTGGKYPGIVMIHEWWGLNDNIKDMARHMASEGYVVLAADLYKGQVTTASSQAQQLATGVRNHPGEAVKNLQAAVSYLRNDSSVDASKIGSLGWCFGGDWSLQLALNEKMNATGLYYGRPVTDPKALSVIKWPVLGIFGSADQSIPVEQVNAFKQALDKDGIQNEIHVYNGVGHAFANPSGPNYAPTETKDAWQKTLAFFDKHLKGETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVK6</accession>
    <name>A0A075MVK6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2-oxoacid oxidoreductase (ferredoxin)</fullName>
            <ecNumber evidence="2">1.2.7.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NTE_01233</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 2-oxocarboxylate + 2 oxidized [2Fe-2S]-[ferredoxin] + CoA = an acyl-CoA + 2 reduced [2Fe-2S]-[ferredoxin] + CO2 + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42316"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="EC" id="1.2.7.11"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterodimer composed of an alpha and a beta subunit.</text>
    </comment>
    <dbReference type="EC" id="1.2.7.11" evidence="2"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVK6"/>
    <dbReference type="STRING" id="1459636.NTE_01233"/>
    <dbReference type="KEGG" id="nev:NTE_01233"/>
    <dbReference type="eggNOG" id="arCOG01606">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017038_1_0_2"/>
    <dbReference type="OrthoDB" id="31112at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018491">
        <property type="term" value="F:2-oxobutyrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019164">
        <property type="term" value="F:pyruvate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000022">
        <property type="entry name" value="2-oxoglutarate ferredoxin oxidoreductase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000009">
        <property type="entry name" value="2-oxoglutarate ferredoxin oxidoreductase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="entry name" value="Pyruvate-ferredoxin oxidoreductase, PFOR, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022367">
        <property type="entry name" value="2-oxoacid/accept_OxRdtase_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053400">
        <property type="entry name" value="2-oxoacid_Fdx_oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033412">
        <property type="entry name" value="PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050722">
        <property type="entry name" value="Pyruvate:ferred/Flavod_OxRd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019752">
        <property type="entry name" value="Pyrv/ketoisovalerate_OxRed_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002880">
        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03710">
        <property type="entry name" value="OAFO_sf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041170">
        <property type="entry name" value="Oxoac_fdxalpha_Archa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32154:SF16">
        <property type="entry name" value="PYRUVATE FLAVODOXIN_FERREDOXIN OXIDOREDUCTASE DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32154">
        <property type="entry name" value="PYRUVATE-FLAVODOXIN OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17147">
        <property type="entry name" value="PFOR_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01558">
        <property type="entry name" value="POR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01855">
        <property type="entry name" value="POR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53323">
        <property type="entry name" value="Pyruvate-ferredoxin oxidoreductase, PFOR, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyruvate/ketoisovalerate oxidoreductase catalytic" evidence="6">
        <location>
            <begin position="16"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding" evidence="7">
        <location>
            <begin position="256"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate:ferredoxin oxidoreductase core" evidence="8">
        <location>
            <begin position="533"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF83304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="650" mass="71040" checksum="E4F112EF2129D774" modified="2014-10-29" version="1">MMVVNSLSWVIGGAQGSGVDSAANIFSRACAVGGLHVFGKREYYSNIKGEHSYFTVRVAEKRIRSPVDEINILVSFDAETVFRHFDEVTPGGAIFYDSDAAETKLSEVPTIDDYAAARIQSTLEKAGLEPTVQGALEHAKKRGVTLYPLPYFQLLEDFAQKMKDPSLSKLARMTNVMALAASMALLEFDSEILAKGIRHIFHAKQRVAELNVKAAYHIYEYAKSKFARDGFNYRLTTKTPEPGIIAVQGSQSSALGKMVAGCRFQTYYPITPASDDSEFLESNEVLELYDSGKKGSTVVVQTEDEIAAITMAIGGALAGARSATATSGPGFSLMAEAMGWAGINEVPVVVSLYQRAGPSTGLPTRHEQGDLHFAIHAGHGEFPRIVLASGDIEESFYDTVKAFNFAEKYQVPVIHMLDKAIANSITTCPAFDPSRVKIERGAIATKITDAEKGAAGNYLRFKLSDNPVSPRIPLGTEGAIFWNTGDEHTEEGHITEDPEVRSRMVEKRMGKLEVALKEIPDEDKAVMYGDRDAKIAIIGWGSTKGVVLDAMEKLAEEGIKCKFVQVRLLNPFPADLVKSMIGNDAEVIVDIEMNYTAQLGALIRQHTGIEPDHLVVKYNGRPMSLEEVYNSVKRIISGKAPRRQVLKNGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVP9</accession>
    <name>A0A075MVP9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Superoxide dismutase</fullName>
            <ecNumber evidence="2 6">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NTE_01311</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the iron/manganese superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="2 6"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700161.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVP9"/>
    <dbReference type="STRING" id="1459636.NTE_01311"/>
    <dbReference type="GeneID" id="41597113"/>
    <dbReference type="KEGG" id="nev:NTE_01311"/>
    <dbReference type="eggNOG" id="arCOG04147">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031625_0_1_2"/>
    <dbReference type="OrthoDB" id="32917at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.990:FF:000001">
        <property type="entry name" value="Superoxide dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.55.40.20:FF:000004">
        <property type="entry name" value="Superoxide dismutase [Fe]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.990">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="entry name" value="Iron/manganese superoxide dismutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001189">
        <property type="entry name" value="Mn/Fe_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019833">
        <property type="entry name" value="Mn/Fe_SOD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019831">
        <property type="entry name" value="Mn/Fe_SOD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43595">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S26, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43595:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00081">
        <property type="entry name" value="Sod_Fe_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000349">
        <property type="entry name" value="SODismutase"/>
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    </dbReference>
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        <property type="entry name" value="MNSODISMTASE"/>
    </dbReference>
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        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), C-terminal domain"/>
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    </dbReference>
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        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00088">
        <property type="entry name" value="SOD_MN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Manganese/iron superoxide dismutase N-terminal" evidence="7">
        <location>
            <begin position="4"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="8">
        <location>
            <begin position="99"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000349-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF83379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="207" mass="23273" checksum="D646551813A3D758" modified="2014-10-29" version="1">MANFTLPQLPYAYDALEPHIDATTMQIHHTKHHQAYTDGLNKALGSLDAKFQSMDVVDILKNIDTVPESARGAVNFHGGGYNNHTLFWNNMKKGGGGEPSGELADAIKKAFGSFADFKTKFQTDSVAVQGSGWGWLVKNGSGGVQFITMPNQTSPWTRWKAEKMTPLLGLDVWEHSYYLKYQNRRADYVTAWWNVVNWDEVAKRFKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVW3</accession>
    <name>A0A075MVW3_9ARCH</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03367</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701808.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVW3"/>
    <dbReference type="GeneID" id="41599013"/>
    <dbReference type="KEGG" id="nev:NTE_03367"/>
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    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="203" mass="23060" checksum="30467D41B76474C7" modified="2014-10-29" version="1">MLEAPATESKPNEIRYRTGIPTLTSFENNFSDSIDYYKVKEGQYSYLDRAIQKGTTLLSNTEMDEYFKTFSDKGYKFAVTSADGIMTRYYTINYFEPPISLSNHNVLISILDKLDSSRQDLSQAETTYLSDAINRPYRWTQIGDSAASDIVKRISAQSNEFNVPTSQGEKTMRIMYIGPFSEELRLPEFQAMYGQITASTGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MW33</accession>
    <name>A0A075MW33_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NTE_02792</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="AIF84832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="STRING" id="1459636.NTE_02792"/>
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    <dbReference type="eggNOG" id="arCOG02673">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="8553at2157"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="EMC3/TMCO1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038978">
        <property type="entry name" value="MJ0935"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42198">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42198:SF1">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01956">
        <property type="entry name" value="EMC3_TMCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF84832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="197" mass="22550" checksum="1CD867CCBA6C3C5F" modified="2014-10-29" version="1">MIDFGSLILQLFSPQYTRHPIFPDFLTATLVAMAISVGMSFAFAMLRRKTTDIDRVNRIMKETNDWRKAYTAAVKKGNKDEIEELKKKQAYVNKMALEVQQQQMRPMLIYMLPSFLIWIFVFPSIFGQVVAISPIHIPWIMCSDQDVQNHQQLDDKGNPKGACEVPGEVYLWGWFLLTSFAFSGIVGKVTKTSMPSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MW62</accession>
    <name>A0A075MW62_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative Fe-S oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_03355</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MW62"/>
    <dbReference type="STRING" id="1459636.NTE_03355"/>
    <dbReference type="KEGG" id="nev:NTE_03355"/>
    <dbReference type="HOGENOM" id="CLU_826220_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF85383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="338" mass="38887" checksum="0BA1B27A83F04D2F" modified="2014-10-29" version="1">MTKTINTEEWSKYLRSKSVDLSNKRLLVSNLLGSEQEVDLSEAPNCGGLGRIRHFKIETSTGWPSNPLPIAPACKALNLPMQDVMRAQVFQNGACNWRCWYCFVPFNLLSADVERSRWVSASDLVNLYLNENDRPSVIDLSGGQPDLIPEWTPWMMEELIARGLQDSVYLWSDDNLSNDYFWRYLSGEQLELVRGYKNYGRVCCFKGFDRESFSFNTLADPDLFDFQFELIRKFIELGIDTYAYVTLTSPADTDRISLKVRNFVDKLQQVHTNLPLRTIPLEIAIFSPVKSRITTSNNDAISRALTNQEVAIQEWNNELRRRYSDNELARPITQVILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MW93</accession>
    <name>A0A075MW93_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA-like domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701821.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MW93"/>
    <dbReference type="STRING" id="1459636.NTE_03380"/>
    <dbReference type="GeneID" id="41599026"/>
    <dbReference type="KEGG" id="nev:NTE_03380"/>
    <dbReference type="eggNOG" id="arCOG00280">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_442559_0_0_2"/>
    <dbReference type="OrthoDB" id="45996at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd01127">
        <property type="entry name" value="TrwB_TraG_TraD_VirD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002789">
        <property type="entry name" value="HerA_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051162">
        <property type="entry name" value="T4SS_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30121:SF6">
        <property type="entry name" value="SLR6007 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30121">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YJGR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12846">
        <property type="entry name" value="AAA_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01935">
        <property type="entry name" value="DUF87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase HerA central" evidence="1">
        <location>
            <begin position="303"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="617" mass="68824" checksum="866768DB4FADE5AA" modified="2014-10-29" version="1">MDIFTYEIQPTNFDSLPDEKQETLLTRFASLLNTAGKITMTLARESVDFGGQRFYTNKTYVSSPEEQFGEYLASLGFKFRTVDAAPTLEILSENTRHVIAKYTHDGPDSPPTGRFGRLLVLTGLRPAMSPAWINSLLQHCHIVVVRTRKIDSDQALSMAQKYKSTIEAAAAKKPSLIPRLERAAAVYQGLQAQRTALFYTSVSCAILANSNKDLDIQSKSFIKSMKAAEVRFDVVPFLQRDAALGNWRKDLILELGSLAITFPFVSSDLLEVQGGMLLGQNVITKAPVVYDYRLRDNYNVWLLAASGSGKSVTAKVILRRMTENYPDAHVYVVDPQGEYEQISDYFGLTVTKLTDGINNKSVRRMGFDPYELFDPIDVPQVICDMAKADSLARNEITAKSASATSIFELYDKVDENTKKHLVQLVQGPFAELFKKGAGDTTEISTKTVISLEGAFDNEEREGVLLTLALARAWKSIVAAPRHLPKILVIDEGWLLFKIPTAARFVEMIARTGRKLNVLFLFITQRPADVLESEKGRVILENSDTRILLRNAEIASQEVANALWLSKRERDILPLLMKGEALIFTGEHRLRVRITPASPEELAIFSTSPNSFTPECPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWA9</accession>
    <name>A0A075MWA9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Na+/proline symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">NTE_02904</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701428.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWA9"/>
    <dbReference type="STRING" id="1459636.NTE_02904"/>
    <dbReference type="GeneID" id="41598582"/>
    <dbReference type="KEGG" id="nev:NTE_02904"/>
    <dbReference type="eggNOG" id="arCOG01319">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018808_15_3_2"/>
    <dbReference type="OrthoDB" id="9779at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046942">
        <property type="term" value="P:carboxylic acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11474">
        <property type="entry name" value="SLC5sbd_CHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018212">
        <property type="entry name" value="Na/solute_symporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050277">
        <property type="entry name" value="Sodium:Solute_Symporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48086">
        <property type="entry name" value="SODIUM/PROLINE SYMPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48086:SF3">
        <property type="entry name" value="SODIUM_PROLINE SYMPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00456">
        <property type="entry name" value="NA_SOLUT_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0915">Sodium</keyword>
    <keyword evidence="11" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="6" id="KW-0769">Symport</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="314"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="394"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="424"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="453"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AIF84942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="507" mass="54228" checksum="1FEA1067B00AE8E5" modified="2014-10-29" version="1">MAGLDGFGIAIAAFLVLSLVVGTLTSRLVKKSSKRYMVAGKSLPLFFVGTMLAAQSIDGNSSLGNVSLVYQFGFWAGAAIPIGLGVCLILTGTVYGKRLNKMALLTLPDFYYRRFGNGAEGISGVLMMISFIVLVAGNFAASGFILQSVFGIDLFWGMLIAALIVLVYTYAGGLFSSAYTDIFQIYLAIGAFWAAFLFFAGGFYGVDFGTILGNAPPAYLDLSGLVDPANGAYVNWASIMALGLGDIVALDFMERVFAARDGRTAQRGAFMGAGLTLFTVIPTSMMGIIALFVLPNIADPFTAYPELAINHMPFPIGAALMMGVLGASMSTANGGLLAISSVMSRNIIQRDILRRMLKRPGMEDKKLLMTTRLFTIPMMVAAFILGYLLPQPGIYLVLAFDIVFAGAWAPLTLGLFWKKANMPAAITSLIVGSSIRLLLFLTMPPDLAGLDTMIPPPISFAAFVIVALATQKRYPGAQRHGVIEYVPPEEDVVKGEDLKGYMEPVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWG1</accession>
    <name>A0A075MWG1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zn-dependent alcohol dehydrogenase</fullName>
            <ecNumber evidence="9">1.1.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NTE_03440</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.1" evidence="9"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701872.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWG1"/>
    <dbReference type="STRING" id="1459636.NTE_03440"/>
    <dbReference type="GeneID" id="41599078"/>
    <dbReference type="KEGG" id="nev:NTE_03440"/>
    <dbReference type="eggNOG" id="arCOG01455">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_2_2"/>
    <dbReference type="OrthoDB" id="73567at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030554">
        <property type="term" value="F:adenyl nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043168">
        <property type="term" value="F:anion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051262">
        <property type="term" value="P:protein tetramerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08240">
        <property type="entry name" value="6_hydroxyhexanoate_dh_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000039">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050129">
        <property type="entry name" value="Zn_alcohol_dh"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43401:SF4">
        <property type="entry name" value="D-ARABINOSE 1-DEHYDROGENASE (NADP(+))"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43401">
        <property type="entry name" value="L-THREONINE 3-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="8">
        <location>
            <begin position="8"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF85468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="351" mass="38044" checksum="575918892454E456" modified="2014-10-29" version="1">MKAARIVHVKEPLQIQQLETPKPKGIEVLVRIISSGVCHSDIHLWEGGYEGIEGQFMKTTDRGVKYPLTPGHEIAGVVEATGEGVEGLSRGDRVIVYPWIGDGTCPACRAGEENLCDKPRSLGVYTEGGYAEYVLASSYKYLIKIDDKLDFDVAAILSCSALTAYTAVKNASLRPDEDVVIVGVGGLGLMAIQVIKSLTGARVIAMDIDDEKLKVAKSNGADFVINSKKDDPVKGVMELTHKLGADSVIDFVNASKTVETDMQMLRRRAKVVLVGLYGGELKLNLVSMPTRAYRLIGSYTGNLRDLAELVSLTERGVIKPIVSHKFKLEQATEALTMLKEGKITGRGVLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWL5</accession>
    <name>A0A075MWL5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWL5"/>
    <dbReference type="STRING" id="1459636.NTE_03490"/>
    <dbReference type="KEGG" id="nev:NTE_03490"/>
    <dbReference type="HOGENOM" id="CLU_2490282_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="86" mass="9799" checksum="8101517FE0CAC4E4" modified="2014-10-29" version="1">MTAKSSRAIKEERVRIHPTFKDHLLEQLMTAFYDGRGHTDKIKGTFDLGDAFLMRISNFRTGELEVINNLCNFKVSKISSVPLILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWL6</accession>
    <name>A0A075MWL6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NTP pyrophosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NTE_03007</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701512.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWL6"/>
    <dbReference type="STRING" id="1459636.NTE_03007"/>
    <dbReference type="GeneID" id="41598677"/>
    <dbReference type="KEGG" id="nev:NTE_03007"/>
    <dbReference type="eggNOG" id="arCOG01072">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040940_5_2_2"/>
    <dbReference type="OrthoDB" id="51434at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:coenzyme A diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03426">
        <property type="entry name" value="NUDIX_CoAse_Nudt7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045121">
        <property type="entry name" value="CoAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992:SF11">
        <property type="entry name" value="MITOCHONDRIAL COENZYME A DIPHOSPHATASE NUDT8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992">
        <property type="entry name" value="NUDIX HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="7">
        <location>
            <begin position="27"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF85042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="191" mass="21562" checksum="D650850A1C0E9DC6" modified="2014-10-29" version="1">MQKEELLRHLGGALTKKGVHMPQDATTSIPAAVLVIIHYHHRKVPYVFLTKRSAGLRSHSSEISFPGGRHAEGDATLLETALRETQEEIGIVFSPSDIAGSLQVVRTMTSNHYIVPFVTVQDMLPRYRVSAHEVEEVLDAPLIETLRTIEPDTEHYRLSKNAYRFTYRGNVIWGATARIMKQLYDSLIRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWX9</accession>
    <name>A0A075MWX9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Dolichol-phosphate mannosyltransferase</fullName>
            <ecNumber evidence="8">2.4.1.83</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Dolichol-phosphate mannose synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Dolichyl-phosphate beta-D-mannosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Mannose-P-dolichol synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">NTE_01723</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.83" evidence="8"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWX9"/>
    <dbReference type="STRING" id="1459636.NTE_01723"/>
    <dbReference type="KEGG" id="nev:NTE_01723"/>
    <dbReference type="eggNOG" id="arCOG00894">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039727_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004582">
        <property type="term" value="F:dolichyl-phosphate beta-D-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06442">
        <property type="entry name" value="DPM1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000119">
        <property type="entry name" value="Dolichol-phosphate mannosyltransferase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039528">
        <property type="entry name" value="DPM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007267">
        <property type="entry name" value="GtrA_DPMS_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398:SF1">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04138">
        <property type="entry name" value="GtrA_DPMS_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 25" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16" id="KW-0464">Manganese</keyword>
    <keyword evidence="15 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 25" id="KW-0808">Transferase</keyword>
    <keyword evidence="11 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 22" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="23">
        <location>
            <begin position="15"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="GtrA/DPMS transmembrane" evidence="24">
        <location>
            <begin position="265"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00053724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00074878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00082336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00082614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00083744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF04138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="AIF83784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="390" mass="43536" checksum="C1AB25E0AFFBCF67" modified="2014-10-29" version="1">MPQELVVKQDKMPLSVILPTYNESQNITKMIDSIAEALPRNTPAEIIVVDDNSPDGTADIAANHAASLAKQDKRFRIRVVRRAGKQGLSSAILAGVHEATGEIVVVMDSDLSHPAHTIPKMLEEIKQSKCDIVVASRYIKGGAISGWPFKRKLMSKGATKIAKYSLGIKVKDPMSGFFAFRRHIIHGIKFDSIGYKMLLEMLVKVKGARIKEIPYTFTNRCAGASKLDSEVVFDYIRAVWRLYRYGRAAPSERRTSVRFFSKAGRFYTVGASGLLINYLVSFILTTLFQEIWYLHAAIVGITFSITSNFILNKIWTFEDMDFVARKTLLQYGMFAGFSSFGALVQLGMMYALVEYQGVGKEIALVLAVGAASIGNFLLNKKWTFKEKVWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWY6</accession>
    <name>A0A075MWY6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Plastocyanin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_03128</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701607.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWY6"/>
    <dbReference type="STRING" id="1459636.NTE_03128"/>
    <dbReference type="GeneID" id="41598788"/>
    <dbReference type="KEGG" id="nev:NTE_03128"/>
    <dbReference type="eggNOG" id="arCOG02926">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_982176_0_0_2"/>
    <dbReference type="OrthoDB" id="4392at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000923">
        <property type="entry name" value="BlueCu_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052721">
        <property type="entry name" value="ET_Amicyanin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36507">
        <property type="entry name" value="BLL1555 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36507:SF1">
        <property type="entry name" value="BLL1555 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00127">
        <property type="entry name" value="Copper-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="Blue (type 1) copper" evidence="4">
        <location>
            <begin position="203"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF85162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="283" mass="30760" checksum="D7B2FFDC2D9D16FF" modified="2014-10-29" version="1">MNYHINNYCNSSMKKELLIMAGVVAVFVAGGVALMSSGLLPEENARNFNALSNITLKTENIVIKEPTKDDNTYIYAINDVAKQAWEIAEQDSGVQDILAQAKGSAITIAAVQPTAFVDPSGKVTSSGAGQVIITANRQLVGGNPYSDAQSFSAIAGKQGESHQQIWNVFVDMDKNKVMNIANENERVMSNTLRKDIVYGGMNMYMPDAAVTQAGSTVKWINESNIPHNVVGTYRTESGKATSIDSGFFNNNESFQYKFAEKGTFEYHCTIHSEEGMKGTIVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MX21</accession>
    <name>A0A075MX21_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UDP-N-acetyl-D-mannosaminuronate dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.336</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_03160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.336" evidence="3"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MX21"/>
    <dbReference type="STRING" id="1459636.NTE_03160"/>
    <dbReference type="KEGG" id="nev:NTE_03160"/>
    <dbReference type="eggNOG" id="arCOG00252">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069297_0_0_2"/>
    <dbReference type="OrthoDB" id="59839at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089714">
        <property type="term" value="F:UDP-N-acetyl-D-mannosamine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028359">
        <property type="entry name" value="UDP_ManNAc/GlcNAc_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43491">
        <property type="entry name" value="UDP-N-ACETYL-D-MANNOSAMINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43491:SF1">
        <property type="entry name" value="UDP-N-ACETYL-D-MANNOSAMINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500136">
        <property type="entry name" value="UDP_ManNAc_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDP-glucose/GDP-mannose dehydrogenase dimerisation" evidence="2">
        <location>
            <begin position="187"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF85192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="300" mass="33740" checksum="1A0683AD2725591B" modified="2014-10-29" version="1">MAFNFLATLTPMNGKKVLVIGLGQIGYSNAEYMTMKGLTVDGYDISEKAVQRALDDQVIRKRASNFAGYDYYIICISTHRPEDMFQPYLDGLFDIARQLLYEGKQGALVGIDSTITRGTSEKVLEMLRHKMHVVHVPHRYFGPEKHDHGVNQTRVIGGCEPCCIDKARQFYGDMLDIPLHPVESVEVAELCKIVENSYRFMEIAFAEELKVFCDRSGIDFADLRSAINTKWNIKVLEPREGIGGHCLPKDSQMFLNLSKNLLATSIIDAAKKVDEEYRAHIGCPVPSSSSSKVQSMQQLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MX69</accession>
    <name>A0A075MX69_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl23</name>
        <name evidence="6" type="ORF">NTE_01834</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit. Contacts protein L29.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226986918.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MX69"/>
    <dbReference type="STRING" id="1459636.NTE_01834"/>
    <dbReference type="GeneID" id="41597598"/>
    <dbReference type="KEGG" id="nev:NTE_01834"/>
    <dbReference type="eggNOG" id="arCOG04072">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037562_4_1_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01369_A">
        <property type="entry name" value="Ribosomal_uL23_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_uL23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011118">
        <property type="entry name" value="PRK14548.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11620">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L23A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF83894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="111" mass="12123" checksum="A15C5B5BB18CA19A" modified="2014-10-29" version="1">MSKTDNSNKATATTAAAAPADTTMTAEEATVIILAPYVTEKTFNQIEKENKLSFMVADQASKHQIIEAMRILYETEVSEVNTARTIQGKKAFVKFKEPEGARNLATKLGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MX91</accession>
    <name>A0A075MX91_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01859</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700603.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MX91"/>
    <dbReference type="STRING" id="1459636.NTE_01859"/>
    <dbReference type="GeneID" id="41597621"/>
    <dbReference type="KEGG" id="nev:NTE_01859"/>
    <dbReference type="HOGENOM" id="CLU_1064034_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="283" mass="29829" checksum="F3E2DB1B687F5889" modified="2014-10-29" version="1">MLAGNNLLYVVVIIAVGGLLVVPLVANATQQQAYVGILPSGSRVVAGVRTDTATVITPVMSSLGFNNHRDYVAYVMHIDAINGNQGIGAGWLSYKDTSTSLVINYDLIYVKPNGSGPTHNLVNQLSSGSQPRLIVTQNAQSGTSANCWTGQAITGSLSNVYSYCFGTGTFSTGSIAGVTGRTFSIYGAGSNTMPGEFDGNHYYYWNSGVLTQDSSTYFSTGSLVKCYTTNGVSSPGWLIDYKAKYNAGGTQLIDKVDVGPSLATTDDCVTSGNFAQQWELPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MXF3</accession>
    <name>A0A075MXF3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700647.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MXF3"/>
    <dbReference type="STRING" id="1459636.NTE_01925"/>
    <dbReference type="GeneID" id="41597673"/>
    <dbReference type="KEGG" id="nev:NTE_01925"/>
    <dbReference type="HOGENOM" id="CLU_2534796_0_0_2"/>
    <dbReference type="OrthoDB" id="376488at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="83" mass="9053" checksum="7DC08BA85F4EB99D" modified="2014-10-29" version="1">MSFAPSSHDDNYNPDLRRAVEKALDSILGEDPKNALMRVLVESHGISFEGDRRSSLQDVEKALGTVLGAGSEIITELVRKELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MY11</accession>
    <name>A0A075MY11_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03509</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MY11"/>
    <dbReference type="KEGG" id="nev:NTE_03509"/>
    <dbReference type="HOGENOM" id="CLU_126923_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="182" mass="19618" checksum="53EF7ECB37F5E740" modified="2014-10-29" version="1">MIHARKKTNALETFQNKVNSFLICLCTALSATLVVSTDGSLINESFSAVQVPSESSSPPSTSSPLIQNSTRDTTKPFGAIISPAPLDVVPLNVPFIVNGTASDNVEISTVEVRAVNLADTNGTTYALATSSDRYAHWTFTLTIPDETFENITVRITDTSGNMKWMTHRVNITNIAATTLPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MYG8</accession>
    <name>A0A075MYG8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Myo-inositol-1-phosphate synthase</fullName>
            <ecNumber evidence="2">5.5.1.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.5.1.4" evidence="2"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700911.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MYG8"/>
    <dbReference type="STRING" id="1459636.NTE_02260"/>
    <dbReference type="GeneID" id="41597975"/>
    <dbReference type="KEGG" id="nev:NTE_02260"/>
    <dbReference type="eggNOG" id="arCOG04213">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050011_0_0_2"/>
    <dbReference type="OrthoDB" id="80661at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004512">
        <property type="term" value="F:inositol-3-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006021">
        <property type="term" value="P:inositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052199">
        <property type="entry name" value="MIPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013021">
        <property type="entry name" value="Myo-inos-1-P_Synthase_GAPDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43125">
        <property type="entry name" value="INOSITOL-3-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43125:SF1">
        <property type="entry name" value="INOSITOL-3-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01658">
        <property type="entry name" value="Inos-1-P_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myo-inositol-1-phosphate synthase GAPDH-like" evidence="1">
        <location>
            <begin position="184"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="342" mass="36557" checksum="C8539D99A67129F4" modified="2014-10-29" version="1">MADIRVAVIGVGNVGATFVQGVQYYGNSSSNNSKNAVGLWHQKVAGFHPSNVKIVAAFDVNPAKVGRPLAEVATSSTKKYCEVSSKVSVDAGLALDNAYDGQKPATTSPPDFARALEDSRADIVLNLISSGMDKSSAEYARAALKAGASFVNATPAKLANSPLAAKFAQKKLVLAGDDLLSQFGGTAFHKGMIDFMVERGVHVSKSYQLDVGGSEETKRTMDERIKMLKRGMKTGAIGMEAPYEFESVAGTTEYTDFLGDSRNSYYWMSSEGFLGSKIIMDLTLRTSDGANAGNVLIDVVRASMAKIPVAKKVPAINAYGFKNPPKKAKVRKAYADFVEMFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MZV4</accession>
    <name>A0A075MZV4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NurA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02727</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="STRING" id="1459636.NTE_02727"/>
    <dbReference type="GeneID" id="41598417"/>
    <dbReference type="KEGG" id="nev:NTE_02727"/>
    <dbReference type="eggNOG" id="arCOG00367">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_825391_0_0_2"/>
    <dbReference type="OrthoDB" id="8506at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018977">
        <property type="entry name" value="NurA_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09376">
        <property type="entry name" value="NurA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00933">
        <property type="entry name" value="NurA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NurA" evidence="1">
        <location>
            <begin position="75"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="336" mass="36541" checksum="E03ABE7E5C45D064" modified="2014-10-29" version="1">MATQLNPPASISLGDFGIMESVSKCLTPKLDELRGKKILFSSDDKTLVPAEGWGARPSSYCATTITTFRPIRESTMVAAIDSSSIKLAETEEGALYAIKCGIAMAYGGAALMHFKIGPMLFYLSESTVFDSELDDRLARLVLADSDIARRLVRVRAERAIQHELSSHLHNAIILVDGSLRTSVFEDRNRSMAKIAENCVLHKNLIAGISKNTKLKILERAAAPLAKVPGPAYIEVDVIIKSLVRGSVGNNLMAKLDKSTPVLRVDIVGDKNQALGRLLGNDPIACGYPETLRLAHHISTFTNTEVTCLRSHVLNSYDVTELAADDIRHTLLGSIMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N016</accession>
    <name>A0A075N016_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NCAIR mutase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02799</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701346.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N016"/>
    <dbReference type="STRING" id="1459636.NTE_02799"/>
    <dbReference type="GeneID" id="41598487"/>
    <dbReference type="KEGG" id="nev:NTE_02799"/>
    <dbReference type="eggNOG" id="arCOG02465">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065705_0_0_2"/>
    <dbReference type="OrthoDB" id="372165at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039476">
        <property type="entry name" value="P2CMN_synthase_LarB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000031">
        <property type="entry name" value="PurE_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033503">
        <property type="entry name" value="LarB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43064">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43064:SF1">
        <property type="entry name" value="SLL1489 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00731">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01001">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52255">
        <property type="entry name" value="N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PurE" evidence="1">
        <location>
            <begin position="125"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="262" mass="27257" checksum="BCCF9F4CBA4A756D" modified="2014-10-29" version="1">MDLRTILEKFAKGAITAEEAQKEISIHAIEHVDNIARLDVGREMRRGLPEIVFAERKEYADTLQIAVAAVKRNGQVVVSRVKKKDLAKLASALKKKGLFVEVGRNSTTILVAAANKSQKQKQALGRVGIMAAGTSDIGVAEEARLVAEAMGCDVITSYDVGIAGMHRVFPALKEMLAKKVGAIVVVAGMEGALASVVASMVDVPVVGVPTSVGYGFGADGIAALASMLQSCTLGLAVVNIDNGVGAGAFAASVAKSATRQTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N0A0</accession>
    <name>A0A075N0A0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Urease accessory protein UreF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_02886</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701412.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N0A0"/>
    <dbReference type="STRING" id="1459636.NTE_02886"/>
    <dbReference type="GeneID" id="41598565"/>
    <dbReference type="KEGG" id="nev:NTE_02886"/>
    <dbReference type="eggNOG" id="arCOG04530">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049215_4_0_2"/>
    <dbReference type="OrthoDB" id="1740at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4190.10">
        <property type="entry name" value="Urease accessory protein UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01385">
        <property type="entry name" value="UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002639">
        <property type="entry name" value="UreF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038277">
        <property type="entry name" value="UreF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33620">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33620:SF1">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01730">
        <property type="entry name" value="UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009467">
        <property type="entry name" value="Ureas_acces_UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF84924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="233" mass="25636" checksum="FC13CCF40B8B78C8" modified="2014-10-29" version="1">MSTSSDIADLSMMQLADSFFPTGMYTTSNGLEALFYSGKKLKVSELFALVKIFIEHQMGPADCAALGNAYEYASKSDVQNVIRVDKILHSMKLVQEIRNASARSGTQMLRCTNFFVTENTVLNEYAAAIKSGHAFGPYPVALAVACNALSIPKRKAGLAMLYSFSVGMVGAALRLGMFQHFEGQKIIDELKPVIVRTVNENIGRPVEGMWQFAPQIDIVQMSHEKMASKMFIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N0Y4</accession>
    <name>A0A075N0Y4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ribosomal RNA small subunit methyltransferase Nep1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NTE_03110</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_420835298.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N0Y4"/>
    <dbReference type="STRING" id="1459636.NTE_03110"/>
    <dbReference type="GeneID" id="41598770"/>
    <dbReference type="KEGG" id="nev:NTE_03110"/>
    <dbReference type="eggNOG" id="arCOG04122">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055846_1_3_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070037">
        <property type="term" value="F:rRNA (pseudouridine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18088">
        <property type="entry name" value="Nep1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005304">
        <property type="entry name" value="Rbsml_bgen_MeTrfase_EMG1/NEP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12636">
        <property type="entry name" value="NEP1/MRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12636:SF5">
        <property type="entry name" value="RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE NEP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03587">
        <property type="entry name" value="EMG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF85144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="216" mass="23576" checksum="FEE4BD884F7EE962" modified="2014-10-29" version="1">MPEEIASHPAVSSRARKLGCKAQETLLDRSYHHAAMKRLPDSGKRGRPDIVHFALMEALSTPLFIQGHLDVYVHTHGNMIISMAGGLRIPKSYFRFEGLMQGLFRDGVVKSDEGAVLMEMVKGTLAELIGEAKPGRVVGLSSAGVQSSAEQVVAKNDVDNCMFVIGGFPKGHFDDDTKALFNCTYSIEGMGLEAHVVIARILYECEKKKRKSSQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MKW5</accession>
    <name>A0A075MKW5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ApeA N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00002</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MKW5"/>
    <dbReference type="STRING" id="1459636.NTE_00002"/>
    <dbReference type="KEGG" id="nev:NTE_00002"/>
    <dbReference type="eggNOG" id="arCOG09518">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1444621_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041223">
        <property type="entry name" value="ApeA_NTD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18862">
        <property type="entry name" value="ApeA_NTD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ApeA N-terminal" evidence="1">
        <location>
            <begin position="8"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="187" mass="21339" checksum="7ECCA6106438D705" modified="2014-10-29" version="1">MFVLDAFEFKGAWWLPDHPDKKIPGVLKFHQSEGAILDLIGSFRTVNDNKTSFETVYGVNTDGKSITLFKVLESNLKFNGAYFSKYISTFIFEGGHFPKYDDIMLKSMSVSYSYLDEWIEISRLHLDDINAKSYTFTYTSPPPVQLGSYNGFDVEVVSSARSDFTLLGQRDFSLKQSLFIKINSTKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ML38</accession>
    <name>A0A075ML38_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ML38"/>
    <dbReference type="STRING" id="1459636.NTE_00062"/>
    <dbReference type="KEGG" id="nev:NTE_00062"/>
    <dbReference type="HOGENOM" id="CLU_896022_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="310" mass="34935" checksum="161350703A1D0EB6" modified="2014-10-29" version="1">MTNCVLLRNAEKHLFQFHSIVGNDSITAPVIAALAIGIVFVILFALFMTPMSAAITRERPPIQEFKRAEQLQEVQLFVKKYPDFTSGFSQNSTAITYHYEISRWGDADGDGYDESFRRLTLSATFEGNGFDIISKDATISGLKQIQIRCDAASIENRTLYNFIPPVYGEENVMNFLQSGRCIEFSTLHDDNNNDDDNKSYSPLTLTIEGFKSAYQAGKEIDFIVKVSGYGRLCTYPNVAIQNVNTKQVVWYSRSPIGYNCEPAHDINEEFHPRDIGINRGPLILNETGPYRLGASIQGEGRMMKYFEVVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLH3</accession>
    <name>A0A075MLH3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLH3"/>
    <dbReference type="STRING" id="1459636.NTE_00224"/>
    <dbReference type="KEGG" id="nev:NTE_00224"/>
    <dbReference type="HOGENOM" id="CLU_149772_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="162" mass="18597" checksum="C28C4A53E0E72A5C" modified="2014-10-29" version="1">MPIYATENEIHLIKRMLIQRDMTETDEIRTAYKTLQEKYRTYLPKVKPALIDSLLQRQMADPSDDPIFMVEVFTKPGLDPQRVRRYIIEKTGMSPEIYDHGTHYVTNQKLNLEILKEISDSDDVLEVTGEYTGRIGAYGASHEHREIEDTSGAARGRGEPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLR8</accession>
    <name>A0A075MLR8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00359</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLR8"/>
    <dbReference type="KEGG" id="nev:NTE_00359"/>
    <dbReference type="HOGENOM" id="CLU_2461616_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="88" mass="9762" checksum="09A4CBBE2A736CCE" modified="2014-10-29" version="1">MIIPLAELERMEKLIHTLEIVITILRYLPIIIGVLAAISLVLAAFNFVDKSYGWAVVNLLLGLAGVSFVLGVTRRRPRHFAKPSDVAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLS9</accession>
    <name>A0A075MLS9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00011</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699166.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLS9"/>
    <dbReference type="STRING" id="1459636.NTE_00011"/>
    <dbReference type="GeneID" id="41595965"/>
    <dbReference type="KEGG" id="nev:NTE_00011"/>
    <dbReference type="HOGENOM" id="CLU_1998817_0_0_2"/>
    <dbReference type="OrthoDB" id="372429at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="124" mass="14439" checksum="FB181D7D408BB85F" modified="2014-10-29" version="1">MEQADESLPELLELNYFSFSLMKNNREFSLHVESSDFGLSIDFAMKYGEFYDIVNLMQAVLYDDGYKGGPKDLDYLEFEKDNENGEYCLVIGKYVSSFSLYFKDDMEAKKFLSEFQRIAGAFDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MM05</accession>
    <name>A0A075MM05_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA polymerase beta</fullName>
            <ecNumber evidence="3">2.7.7.7</ecNumber>
            <ecNumber evidence="4">4.2.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">5'-deoxyribose-phosphate lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">AP lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">NTE_00434</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">Repair polymerase that plays a key role in base-excision repair. During this process, the damaged base is excised by specific DNA glycosylases, the DNA backbone is nicked at the abasic site by an apurinic/apyrimidic (AP) endonuclease, and POLB removes 5'-deoxyribose-phosphate from the preincised AP site acting as a 5'-deoxyribose-phosphate lyase (5'-dRP lyase); through its DNA polymerase activity, it adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases. It is also able to cleave sugar-phosphate bonds 3' to an intact AP site, acting as an AP lyase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>a 5'-end 2'-deoxyribose-2'-deoxyribonucleotide-DNA = (2E,4S)-4-hydroxypenten-2-al-5-phosphate + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:76255"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:18657"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:195194"/>
            <dbReference type="ChEBI" id="CHEBI:195195"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="3"/>
    <dbReference type="EC" id="4.2.99.18" evidence="4"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699473.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
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    <dbReference type="AlphaFoldDB" id="A0A075MM05"/>
    <dbReference type="STRING" id="1459636.NTE_00434"/>
    <dbReference type="GeneID" id="41596312"/>
    <dbReference type="KEGG" id="nev:NTE_00434"/>
    <dbReference type="eggNOG" id="arCOG00305">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017729_1_0_2"/>
    <dbReference type="OrthoDB" id="8999at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042578">
        <property type="term" value="F:phosphoric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00141">
        <property type="entry name" value="NT_POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07436">
        <property type="entry name" value="PHP_PolX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.110">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.210.10">
        <property type="entry name" value="DNA polymerase, thumb domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002054">
        <property type="entry name" value="DNA-dir_DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037160">
        <property type="entry name" value="DNA_Pol_thumb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002008">
        <property type="entry name" value="DNA_pol_X_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010996">
        <property type="entry name" value="HHH_MUS81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050243">
        <property type="entry name" value="PHP_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029398">
        <property type="entry name" value="PolB_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022311">
        <property type="entry name" value="PolX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047967">
        <property type="entry name" value="PolX_PHP"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006375">
        <property type="entry name" value="PRK08609.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36928">
        <property type="entry name" value="PHOSPHATASE YCDX-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36928:SF1">
        <property type="entry name" value="PHOSPHATASE YCDX-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14791">
        <property type="entry name" value="DNA_pol_B_thumb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14520">
        <property type="entry name" value="HHH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14716">
        <property type="entry name" value="HHH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005047">
        <property type="entry name" value="UCP005047_YshC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00870">
        <property type="entry name" value="DNAPOLXBETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00483">
        <property type="entry name" value="POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47802">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="PHP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="13" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="6" id="KW-0488">Methylation</keyword>
    <keyword evidence="9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0915">Sodium</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase X" evidence="24">
        <location>
            <begin position="1"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Helix-hairpin-helix DNA-binding motif class 1" evidence="22">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Helix-hairpin-helix DNA-binding motif class 1" evidence="22">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Helix-hairpin-helix DNA-binding motif class 1" evidence="22">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Polymerase/histidinol phosphatase N-terminal" evidence="23">
        <location>
            <begin position="343"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00035717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00035726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00044678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00045548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="SMART" id="SM00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="SMART" id="SM00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="AIF82516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="574" mass="62784" checksum="6A187600DD79F4E1" modified="2014-10-29" version="1">MKNGQVAKALRDIGFLTEVEDAENAQFKSRAYYKAADSIEVLEQDVADVYEKGGINALLELPGIGKAIASKIEEYLTTGRIKHLDELREKIPIDISQLGAIEGIGPKTLKAIHQKLGVTDLAGLEKAAREGRLKTVPGITARKEQDILKKIEFTKKSGGRSIIGEVWPLAKKIEARLKGLKGVKLAALAGSARRMKETIGDLDYIVCASEPESVMDFFVKMPEVEEIKSRGPAKAFVRLAGGIDCDLLAVPEKSWGSALLYFTGNKEHNVELRRIAIARGLRLNEWGVFENNEKMVAGASEEDVYKALGLAWIAPEMRENAGEIDLAAKGRLPSLIEYGSLKGDLQVHSDNSDGTATIQEMALAAKEFGLDYIAITDHTKSLAMAGGLDEQELLDQAQKIAELNDKLDSIRVLSSAEVNIGKDGSLDIANNVLDKLDIVGAAIHSHFGLPMEEQTARLVNAAKNPSVDIIFHPTGRLINRREGYPVDISKLTDVARDTSTALEIDAHYNRLDLKDEYVRMAVRKGVKLTIDSDAHHPVHYAFLQFGIGQTRRGWATAADVLNTLPADRLLKALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MM13</accession>
    <name>A0A075MM13_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NTE_00201</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699303.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MM13"/>
    <dbReference type="STRING" id="1459636.NTE_00201"/>
    <dbReference type="GeneID" id="41596126"/>
    <dbReference type="KEGG" id="nev:NTE_00201"/>
    <dbReference type="eggNOG" id="arCOG02358">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015921_0_0_2"/>
    <dbReference type="OrthoDB" id="342253at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050736">
        <property type="entry name" value="Sensor_HK_Regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43711:SF1">
        <property type="entry name" value="HISTIDINE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43711">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="509"/>
            <end position="760"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF82283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="775" mass="87647" checksum="09B09011C871D4A7" modified="2014-10-29" version="1">MSTSNQPEVKNKETAAAAATTEILYGAENAVERGIKFMSNVQKRMDITFDHRGPSIVVEIPSYWDGYLDIIRRGGEIRVVTEITSANVNYCKQIAKIAKVRHLNGMIGGIAMNETEYMATTTLEESRPLTQVIYSNVDEVVRQGRCLFESLWENAIPAEDRLREIEEGVEPERTRVMHGSDQILNWTMESFSKIRETFDSCMTSDGPSILFENAALMKAYAQLKDRGIKLRFLTEITADNLPYCKQIAKIAEVRHLDRVKGTFGIADKRQYAASGIAHKGEVPSRLIVSTVRVFVEHQQYSFDALWEKAMSAEQRIGQIEEGLEPEYIKTIDNSEVQRIVYELLDKAQEEVRIIFSTANAFRRQKRAGGLQHLIAIAKKRRLRIRLLAPLDKNIQKEYERFVRELPPASHHHHHPHNQDDKQIVDIRYIEPGWHSKISLLIVDSRFSLAAELRDDTKETVNEAIGLATLSNSKATVSSYVSMFESMWMQSELHEKLKVHSKMQHEFINIAAHELRTPIQPIIGLSDVLYINTTDDRQRELVTIINRNARRLKTLAEDILDVTKIESHSLKLQKEHFNLRELVADTIQDVKTSQEYKDSKVQLFYKSGGDQDEDSDGGSDDDIVVEADKEKIMQVIRNLLDNALEFTNEGGVVNVEVAKMHTNNDYGEAASDLAAVVSIKDTGAGIAPEILPVMFDKFVTKSNRGTGLGLFISKGIVEAHGGRIWGENNYYCYNRGDGGGSKEKKGKKKGATFTFTLPLKNKDCRFIRPSAKNIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMG1</accession>
    <name>A0A075MMG1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator with CheY-like receiver, AAA-type ATPase, and DNA-binding domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_00356</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699413.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMG1"/>
    <dbReference type="STRING" id="1459636.NTE_00356"/>
    <dbReference type="GeneID" id="41596248"/>
    <dbReference type="KEGG" id="nev:NTE_00356"/>
    <dbReference type="eggNOG" id="arCOG02391">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_15_2"/>
    <dbReference type="OrthoDB" id="2830at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050595">
        <property type="entry name" value="Bact_response_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44591:SF3">
        <property type="entry name" value="RESPONSE REGULATORY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44591">
        <property type="entry name" value="STRESS RESPONSE REGULATOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="2"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF82438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="132" mass="15241" checksum="59A5076DB79C4142" modified="2014-10-29" version="1">MRILVAEDESNILLMYKIFLEGEGHDVITSRDGIECVEQYELWNQKNLPFDVVMMDYRMPKMDGRDAAKRILAIHPGQTIVMITAYSKELEGLFSGIEEIQVLQKPFELDSLLELLKSVYERKRSQPTSSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMG8</accession>
    <name>A0A075MMG8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00248</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699336.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMG8"/>
    <dbReference type="STRING" id="1459636.NTE_00248"/>
    <dbReference type="GeneID" id="41596162"/>
    <dbReference type="KEGG" id="nev:NTE_00248"/>
    <dbReference type="HOGENOM" id="CLU_1912244_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="132" mass="15028" checksum="1A08068AA7F9F245" modified="2014-10-29" version="1">MLAEHQARGIIKTGMSRAWNKDFEYDNFGTKRVVEKVAELLAGKVNGATLSVEEVEEKMKNGSVLMNAISAITNSKYGLKVADIVKKPELTEILIRERVEKIREERNAGEWKPDLEIEKVLDKIFKMIPVNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMI8</accession>
    <name>A0A075MMI8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Probable transaldolase</fullName>
            <ecNumber evidence="5 12">2.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">tal</name>
        <name evidence="13" type="ORF">NTE_00600</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:17053"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the transaldolase family. Type 3B subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.2" evidence="5 12"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699602.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMI8"/>
    <dbReference type="STRING" id="1459636.NTE_00600"/>
    <dbReference type="GeneID" id="41596463"/>
    <dbReference type="KEGG" id="nev:NTE_00600"/>
    <dbReference type="eggNOG" id="arCOG05061">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079764_0_0_2"/>
    <dbReference type="OrthoDB" id="6661at2157"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004801">
        <property type="term" value="F:transaldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00956">
        <property type="entry name" value="Transaldolase_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000018">
        <property type="entry name" value="Probable transaldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00494">
        <property type="entry name" value="Transaldolase_3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022999">
        <property type="entry name" value="Transaldolase_3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004731">
        <property type="entry name" value="Transaldolase_3B/F6P_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018225">
        <property type="entry name" value="Transaldolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033919">
        <property type="entry name" value="TSA/FSA_arc/bac"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00875">
        <property type="entry name" value="fsa_talC_mipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683:SF40">
        <property type="entry name" value="FRUCTOSE-6-PHOSPHATE ALDOLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01054">
        <property type="entry name" value="TRANSALDOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 12" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0704">Schiff base</keyword>
    <keyword evidence="7 12 13" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="12">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00067532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIF82681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="221" mass="24366" checksum="1DD4CCF646181B9D" modified="2014-10-29" version="1">MKIFLDTANLESIKKYNDMGLVDGITTNPTLLSREKENPAQIMREIVRIVKGPVSLEVVGTTYDSMMEEAHRLKKYGKNVVVKIPMLPDGMRAVKKLKEEGIETNVTLVFSANQAVIAAKAGASYVSPFIGRLDDAGQDGMTLVREIVQIFSNYKFTTNVLVASVRHPMHVIEAGKIGAHVVTLPPDILGKMMAHPLTDKGLASFLADWEKVKKENPNLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MN06</accession>
    <name>A0A075MN06_9ARCH</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00562</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MN06"/>
    <dbReference type="KEGG" id="nev:NTE_00562"/>
    <dbReference type="HOGENOM" id="CLU_2490274_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="86" mass="9853" checksum="A355046CE679F9BD" modified="2014-10-29" version="1">MSQGMLTKEEKEHKDEIITLTEEVLHERGLKCDASIAKVSEAELKEILEKVRALRKKKKNVSNSEVIISEDRQREEEEEAEAITCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MN56</accession>
    <name>A0A075MN56_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative Na+-dependent transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NTE_00140</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699261.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MN56"/>
    <dbReference type="STRING" id="1459636.NTE_00140"/>
    <dbReference type="GeneID" id="41596080"/>
    <dbReference type="KEGG" id="nev:NTE_00140"/>
    <dbReference type="eggNOG" id="arCOG02191">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077102_0_0_2"/>
    <dbReference type="OrthoDB" id="11872at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002657">
        <property type="entry name" value="BilAc:Na_symport/Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004710">
        <property type="entry name" value="Bilac:Na_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10361:SF28">
        <property type="entry name" value="P3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10361">
        <property type="entry name" value="SODIUM-BILE ACID COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01758">
        <property type="entry name" value="SBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF82222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="327" mass="36188" checksum="988981DFE0C8DB92" modified="2014-10-29" version="1">MVEKYAPKRELDKNDILLFVAIVASMSAGVLVPSVGRIFQPYLLVWLGGLLFLNLIRMDLGELASTFKTPKKLAILSVTKLLILPLLMYAITKIVYEPLAIPVLLLSGISTGLGAPFVINVTLEGEKNRRQLSLVVAMVIVTSLAVPFVLPSMVYFLLGNSQFKIPILQMIFLLVTALFIPIAAGWFVKKRWPAVAEKVDKRSLPASIVFIALINFGVFAEFSNYFFKKPEFLFVEITASFVLFAAYSAIGYFTGRIVSGKKGKRKELIATGIVVMSYVNNVLVVVFASQFFGPDYAALAAFYNLPYYGLILLLKKLITAEQVKSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNB0</accession>
    <name>A0A075MNB0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ammonia monooxygenase subunit A</fullName>
            <ecNumber evidence="2">1.13.12.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00961</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.13.12.-" evidence="2"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699883.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNB0"/>
    <dbReference type="STRING" id="1459636.NTE_00961"/>
    <dbReference type="GeneID" id="41596792"/>
    <dbReference type="KEGG" id="nev:NTE_00961"/>
    <dbReference type="eggNOG" id="arCOG08676">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1329513_0_0_2"/>
    <dbReference type="OrthoDB" id="7458at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1450.10:FF:000002">
        <property type="entry name" value="Ammonia monooxygenase subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1450.10">
        <property type="entry name" value="Ammonia/particulate methane monooxygenase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024656">
        <property type="entry name" value="AmoA_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037001">
        <property type="entry name" value="NH3/CH4_mOase_suA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12942">
        <property type="entry name" value="Archaeal_AmoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="216" mass="24358" checksum="F6F4F2C11ADAD90F" modified="2014-10-29" version="1">MVWLRRTTHYLFIVVVAVNSTLLTINAGDYIFYTDWMWTSFVVFSVSQSTMLAVGAVYYMLFTGVPGTATYYATIMTIYTWVAKGAWFALGYPYDFIVVPVWIPSAMLLDLTYWATRRNKHAVIIIGGTLVGLSLPLFNMVNLLLIRDPLEVAFKYPRPTLPAYMTPIEPQVGKFYNSPVALGSGASAVLTVPMTALGAKLNTWTYRWMAAWSKWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNB1</accession>
    <name>A0A075MNB1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699308.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNB1"/>
    <dbReference type="STRING" id="1459636.NTE_00210"/>
    <dbReference type="GeneID" id="41596132"/>
    <dbReference type="KEGG" id="nev:NTE_00210"/>
    <dbReference type="HOGENOM" id="CLU_2419873_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="84" mass="10010" checksum="F1ABE803E1D6AD1A" modified="2014-10-29" version="1">MYETKVSARQHVRGDIIRKAIEKNGYFNERFSEVIIKTLEYHGIVFDAEHYYSLYDVERRMQKLLGKEISWSVSKLIEVGVRNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNF6</accession>
    <name>A0A075MNF6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable cytosol aminopeptidase</fullName>
            <ecNumber evidence="6">3.4.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Leucine aminopeptidase</fullName>
            <shortName evidence="6">LAP</shortName>
            <ecNumber evidence="6">3.4.11.10</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Leucyl aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pepA</name>
        <name evidence="8" type="ORF">NTE_00604</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly low.</text>
            <dbReference type="EC" id="3.4.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Release of an N-terminal amino acid, preferentially leucine, but not glutamic or aspartic acids.</text>
            <dbReference type="EC" id="3.4.11.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peptidase M17 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.1" evidence="6"/>
    <dbReference type="EC" id="3.4.11.10" evidence="6"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699606.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNF6"/>
    <dbReference type="STRING" id="1459636.NTE_00604"/>
    <dbReference type="GeneID" id="41596467"/>
    <dbReference type="KEGG" id="nev:NTE_00604"/>
    <dbReference type="eggNOG" id="arCOG04322">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013734_2_2_2"/>
    <dbReference type="OrthoDB" id="18419at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00433">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00181">
        <property type="entry name" value="Cytosol_peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011356">
        <property type="entry name" value="Leucine_aapep/pepB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000819">
        <property type="entry name" value="Peptidase_M17_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023042">
        <property type="entry name" value="Peptidase_M17_leu_NH2_pept"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008283">
        <property type="entry name" value="Peptidase_M17_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002073">
        <property type="entry name" value="PRK00913.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002074">
        <property type="entry name" value="PRK00913.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002083">
        <property type="entry name" value="PRK00913.3-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963:SF23">
        <property type="entry name" value="CYTOSOL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963">
        <property type="entry name" value="LEUCINE AMINOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00883">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02789">
        <property type="entry name" value="Peptidase_M17_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00481">
        <property type="entry name" value="LAMNOPPTDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00631">
        <property type="entry name" value="CYTOSOL_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 8" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytosol aminopeptidase" evidence="7">
        <location>
            <begin position="341"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="347"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF82685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="511" mass="55102" checksum="141B2409C31A6465" modified="2014-10-29" version="1">MVQIRVEKAKIDQKQTSLLVIGVFEGEQDFSQSKELDPSVLTYIKEALENKDFRGTFGSSMVAYTLGKGPMKKIMLLGLGKREKFTDEMARICAGKAAHRARDLGTKEFSILQFSNLDEGLVESMTEGIALALYTFDKYKAQDKDAARVEEVTILINSDSPRFSMIAERASHVADAVNFARDLGNLPPNDCPPAHLASVALSLAADYGMKARVIDRYELENMNMGGIVAVGKGSNNPPKLIILEYNGATASDARPYLLVGKAVTFDTGGISLKPGDKMDEMKFDKCGGCNVLAILRAVASLKLAVNVVGIVPSVENMPSSTAYRPGDIVRMYSGKTVEVLNTDAEGRMILADALAYGIATYNPKAVIDMATLTGAAIIALGANVAALVGNNKQLTDRVRRMAEKAGERVWDLPLYDEFHEQIKSPYADIKNIGGRSGGAITAAAFLSNFVSGTPWVHMDIAGTAWTQDGTYERSYNPKGATGFGIRTLLKLLGEEEKPSASSSSAQGQQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNM0</accession>
    <name>A0A075MNM0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aspartate kinase</fullName>
            <ecNumber evidence="2">2.7.2.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.2.4" evidence="2"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699706.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNM0"/>
    <dbReference type="STRING" id="1459636.NTE_00730"/>
    <dbReference type="GeneID" id="41596582"/>
    <dbReference type="KEGG" id="nev:NTE_00730"/>
    <dbReference type="eggNOG" id="arCOG01806">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103221_0_0_2"/>
    <dbReference type="OrthoDB" id="56543at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027795">
        <property type="entry name" value="CASTOR_ACT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13840">
        <property type="entry name" value="ACT_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CASTOR ACT" evidence="1">
        <location>
            <begin position="150"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="234" mass="26046" checksum="2B3E4F650567354D" modified="2014-10-29" version="1">MSVNEKSITNAVKEVVNNDLSFQDSLQRDYCNISALARIVKPQIDQMLGGKNTSVESIVTALKRSRRDYDVPERPIAAILAGSTVSVKTDVAKVSAAKSKKTIEKVAKSLTQNVDNFISVSESIMSITLVFDDVLLDDVKTMFAHDDVLEVEDDLAAIIVHSPEEIIKTPGCAIAFYNQLARRHINIEDTVSCYTDTIMLVRMDQVGKAFNALTDLISNSRKMPKKKHQHQQHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNN5</accession>
    <name>A0A075MNN5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed RNA polymerase subunit Rpo4</fullName>
            <ecNumber evidence="1">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">DNA-directed RNA polymerase subunit F</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpo4</name>
        <name evidence="1" type="synonym">rpoF</name>
        <name evidence="2" type="ORF">NTE_01093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is less well bound than the others.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the RNA polymerase complex. Forms a stalk with Rpo7 that extends from the main structure.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic RPB4 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="1"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699982.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNN5"/>
    <dbReference type="STRING" id="1459636.NTE_01093"/>
    <dbReference type="GeneID" id="41596909"/>
    <dbReference type="KEGG" id="nev:NTE_01093"/>
    <dbReference type="eggNOG" id="arCOG01016">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2191149_0_0_2"/>
    <dbReference type="OrthoDB" id="25158at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="entry name" value="HRDC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00864">
        <property type="entry name" value="RNApol_arch_Rpo4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005574">
        <property type="entry name" value="Rpb4/RPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010924">
        <property type="entry name" value="Rpo4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39646:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT RPO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39646">
        <property type="entry name" value="RNA POLYMERASE RPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03874">
        <property type="entry name" value="RNA_pol_Rpb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005053">
        <property type="entry name" value="RNA_pol_F_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="1 2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="110" mass="12502" checksum="7954BD675145EC71" modified="2014-10-29" version="1">MTETLEKEIITTAQVKEILDSVKADDMDQIQRWTSDYVGKFAKTDAKTAAKMVKQLVEQCDLTQEEAVEVVNVMPTTLEELRAFTFGWKKLILTETLEKMLSILKSESQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNR6</accession>
    <name>A0A075MNR6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148702006.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNR6"/>
    <dbReference type="STRING" id="1459636.NTE_00775"/>
    <dbReference type="GeneID" id="41596626"/>
    <dbReference type="KEGG" id="nev:NTE_00775"/>
    <dbReference type="eggNOG" id="arCOG00035">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010289_0_2_2"/>
    <dbReference type="OrthoDB" id="372052at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017178">
        <property type="term" value="F:diphthine-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01994">
        <property type="entry name" value="AANH_PF0828-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1490.10">
        <property type="entry name" value="putative n-type atp pyrophosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002761">
        <property type="entry name" value="Diphthami_syn_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030662">
        <property type="entry name" value="DPH6/MJ0570"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022427">
        <property type="entry name" value="MJ0570_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03679">
        <property type="entry name" value="arCOG00187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00290">
        <property type="entry name" value="MJ0570_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12196:SF2">
        <property type="entry name" value="DIPHTHINE--AMMONIA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12196">
        <property type="entry name" value="DOMAIN OF UNKNOWN FUNCTION 71 DUF71 -CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01902">
        <property type="entry name" value="Diphthami_syn_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039123">
        <property type="entry name" value="Diphthamide_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Diphthamide synthase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="229" mass="24752" checksum="468F5C19FDDA00D4" modified="2014-10-29" version="1">MRLAALFSGGKDSTFAIYRARQAGHAVECLITMHPAADDSALFHYPNSRVTRYLAEAMKIPLLESAAVTGTDRDAEIKALAAAVAQAKLLYRVEGIVNGGIASVFQKQAFEEACKEHGLVPVSPLWGAEPEKYMADLLASGFTVMIVGISAMGLEKEWLGKVIDGESLAKLVQLSKKYGFNLAFEGGEAETLVLDCPLYSKRLAVGQATAKWDGQRGIFEILEAELVNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNZ7</accession>
    <name>A0A075MNZ7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lysophospholipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00862</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699807.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNZ7"/>
    <dbReference type="STRING" id="1459636.NTE_00862"/>
    <dbReference type="GeneID" id="41596705"/>
    <dbReference type="KEGG" id="nev:NTE_00862"/>
    <dbReference type="eggNOG" id="arCOG01650">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_955169_0_0_2"/>
    <dbReference type="OrthoDB" id="7531at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051044">
        <property type="entry name" value="MAG_DAG_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11614">
        <property type="entry name" value="PHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="1">
        <location>
            <begin position="24"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="288" mass="33091" checksum="67D0B069DC10532B" modified="2014-10-29" version="1">MTCHYQTASGKINVFEFPSQNPKNDTILCIHGIPSNARIFTYVGTKLSQAGYNVLSMDLPGHGGSEGPRGDVDFEKCLQSINQIVADLKRSGSRVFIMAHSMGSTFALWYAHSFKNSVDGLIIMCPYIHINNIKRSDTEPSAGMFLYLLLRRILTPRSTADMMKVLPQYAKVSGEEFEEVVRKKMINTEYSYRFLVDVLATRNSKVAELADIVDPILLLHGQKDRNVYPQVSEEYLKMLRSQNKELKMFDCDHWFYDAMFFNQDSPKYSEESRIRFISTIRDWLSSFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MP33</accession>
    <name>A0A075MP33_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00897</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699836.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MP33"/>
    <dbReference type="STRING" id="1459636.NTE_00897"/>
    <dbReference type="GeneID" id="41596737"/>
    <dbReference type="KEGG" id="nev:NTE_00897"/>
    <dbReference type="eggNOG" id="arCOG08805">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100103_1_0_2"/>
    <dbReference type="OrthoDB" id="8756at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="203" mass="22918" checksum="B40A1BF9F424EAAA" modified="2014-10-29" version="1">MSGDSVGPEASSSYQSKKTRSVTFRIDSSVIDELQGEADTREISLNVLVNQVLKRYAEWDRYESKIGMMPVPKLMLSTLIDKAISSAKAGGIKEVEVYRDLIVKEAAQIAFNLMKDSVLFMKKHYNLWVVLSVLEEYMKVSGIKADHRIEGSSKHVFVVQHELGENWSLFTKELLTLIFQNLAKVRADIHVTPNTTVAEVILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MP39</accession>
    <name>A0A075MP39_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">polynucleotide 5'-hydroxyl-kinase</fullName>
            <ecNumber evidence="2">2.7.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NTE_00854</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of both single-stranded RNA (ssRNA) and single-stranded DNA (ssDNA). Exhibits a strong preference for ssRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 5'-end dephospho-2'-deoxyribonucleoside-DNA + ATP = a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15669"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:13184"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:136416"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.78"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 5'-end dephospho-ribonucleoside-RNA + ATP = a 5'-end 5'-phospho-ribonucleoside-RNA + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54580"/>
            <dbReference type="Rhea" id="RHEA-COMP:13936"/>
            <dbReference type="Rhea" id="RHEA-COMP:15179"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:138284"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.78"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="2.7.1.78" evidence="2"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699800.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MP39"/>
    <dbReference type="STRING" id="1459636.NTE_00854"/>
    <dbReference type="GeneID" id="41596697"/>
    <dbReference type="KEGG" id="nev:NTE_00854"/>
    <dbReference type="eggNOG" id="arCOG04127">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_738896_0_0_2"/>
    <dbReference type="OrthoDB" id="359472at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051734">
        <property type="term" value="F:ATP-dependent polynucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045116">
        <property type="entry name" value="Clp1/Grc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032319">
        <property type="entry name" value="CLP1_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755">
        <property type="entry name" value="CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755:SF3">
        <property type="entry name" value="POLYNUCLEOTIDE 5'-HYDROXYL-KINASE NOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16575">
        <property type="entry name" value="CLP1_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Clp1 P-loop" evidence="10">
        <location>
            <begin position="95"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIF82930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="374" mass="39976" checksum="1A6D40FF2FC896DE" modified="2014-10-29" version="1">MAPSAVQMVRGPATVQVIGRCHVLGMDVSLRTIEVRAGKALPFELDADCKLDVQGGESWIAGADNAGTCMWQEIAENILALGSAAATTVVVMVVGATDTGKSTFSTYLANLALGRGIVPCIVDGDIGQGDLAPPTALGAAVIKEQVVDLRDAQAGLFEFVGAITPAGAEKLVAQKLKSLVGRMKKTMMMTTTATPAAASLKIVNTDGYSDPLYKWMLASVVSPDVVICMGQDSSNNNNDLARALLSRWELFVAPSSSAQVLKTHSERVGRRMEQYIRHVGDGLVSKSTDAARFFYRNRPIPRNAVLALGPEGMFVALGSRRRIAGFGVIESMDAHQVSIRTGVQDFSTIHASEIRLRKNHEERITFFSSQARGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MP46</accession>
    <name>A0A075MP46_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peroxiredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987193.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MP46"/>
    <dbReference type="STRING" id="1459636.NTE_01225"/>
    <dbReference type="GeneID" id="41597033"/>
    <dbReference type="KEGG" id="nev:NTE_01225"/>
    <dbReference type="HOGENOM" id="CLU_2447520_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant" evidence="1">
        <location>
            <begin position="5"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="89" mass="10250" checksum="9495B7D3288E096B" modified="2014-10-29" version="1">MAAQWEHKNSQIQKIKALEAKVIGVNKETLYSRPKFVGKYRLDFLLLSDRTNKTIKAYCPYGGKGILDFGMTKKKTHILDNSEKNDQDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MP52</accession>
    <name>A0A075MP52_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative cation transport regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700097.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MP52"/>
    <dbReference type="STRING" id="1459636.NTE_01235"/>
    <dbReference type="GeneID" id="41597043"/>
    <dbReference type="KEGG" id="nev:NTE_01235"/>
    <dbReference type="eggNOG" id="arCOG06878">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_179907_0_0_2"/>
    <dbReference type="OrthoDB" id="144741at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1740.70">
        <property type="entry name" value="ChaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009317">
        <property type="entry name" value="ChaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037205">
        <property type="entry name" value="ChaB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06150">
        <property type="entry name" value="ChaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140376">
        <property type="entry name" value="ChaB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="92" mass="10705" checksum="E8082752818A5CD4" modified="2014-10-29" version="1">MPRGKLSERTRKQIDTLPEKAQRTFRKAHESALKQYKSPGKRRRKSDTAEAVAQKVAWSAVKKKYRKSGDKWVSKSSSNNRRSKKTKSKKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPD5</accession>
    <name>A0A075MPD5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Exosome complex component Rrp41</fullName>
            <ecNumber evidence="8">3.1.13.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rrp41</name>
        <name evidence="11" type="ORF">NTE_01343</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'-&gt;5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7 8">Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the RNase PH family. Rrp41 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.-" evidence="8"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700185.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPD5"/>
    <dbReference type="STRING" id="1459636.NTE_01343"/>
    <dbReference type="GeneID" id="41597141"/>
    <dbReference type="KEGG" id="nev:NTE_01343"/>
    <dbReference type="eggNOG" id="arCOG01575">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063514_0_0_2"/>
    <dbReference type="OrthoDB" id="24266at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11366">
        <property type="entry name" value="RNase_PH_archRRP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.70:FF:000004">
        <property type="entry name" value="Exosome complex component Rrp41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00591">
        <property type="entry name" value="Exosome_Rrp41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011807">
        <property type="entry name" value="Rrp41"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02065">
        <property type="entry name" value="ECX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF0">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5 8" id="KW-0271">Exosome</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="9">
        <location>
            <begin position="22"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="10">
        <location>
            <begin position="154"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00062149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIF83411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="246" mass="27242" checksum="0D9CA97DA670DBB6" modified="2014-10-29" version="1">MTQTRNLIDENGKRTDGRTIDELRNVKIVVGTVKNADGSAYIEFGKNKIVAAVYGPREVHPKHLAQPDRCVLRCRYHMSPFSTDTRKNPAPSRREVEISKVMREALEPALMLEDYPRAAIDVFVEVLQSDGGSRCAGITAASVALADAGINMRDIVAACAAGKVDEKIVLDINDTEDKEGGADMPVAYMPRLGQVTLMQLDGKLTKEQFSECLDKAITGCNMVYEIQRQALMQKYFGNETEVKEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPG4</accession>
    <name>A0A075MPG4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01378</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700216.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPG4"/>
    <dbReference type="STRING" id="1459636.NTE_01378"/>
    <dbReference type="GeneID" id="41597174"/>
    <dbReference type="KEGG" id="nev:NTE_01378"/>
    <dbReference type="eggNOG" id="arCOG07262">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_209485_0_0_2"/>
    <dbReference type="OrthoDB" id="8919at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="60" mass="6968" checksum="873F34D76EE0DE84" modified="2014-10-29" version="1">MAREEEKKKKKKEVEEFAEEDDDHFKLYGKRAWEVEYGEKCPTCGKRIDEFGFCACGSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPI9</accession>
    <name>A0A075MPI9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699898.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPI9"/>
    <dbReference type="STRING" id="1459636.NTE_00980"/>
    <dbReference type="GeneID" id="41596809"/>
    <dbReference type="KEGG" id="nev:NTE_00980"/>
    <dbReference type="HOGENOM" id="CLU_1965640_0_0_2"/>
    <dbReference type="OrthoDB" id="6395at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="130" mass="14975" checksum="8A7977A4760AF3B9" modified="2014-10-29" version="1">MIMKNKKKDSRLAGEGDVPAEKWLVAFRNPSGRGPEGSMLVRQFYAPGYYEAYDTVLTHAEKMNLEVLWFREKRNCGPYMNRNYPGLESRCTYCNKKFGHEPVPCASESCELEFCSKECMADHAACRHHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPN2</accession>
    <name>A0A075MPN2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dimethyladenosine transferase (RRNA methylation)</fullName>
            <ecNumber evidence="7">2.1.1.182</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NTE_01095</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.182" evidence="7"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699984.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPN2"/>
    <dbReference type="STRING" id="1459636.NTE_01095"/>
    <dbReference type="GeneID" id="41596911"/>
    <dbReference type="KEGG" id="nev:NTE_01095"/>
    <dbReference type="eggNOG" id="arCOG04131">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041220_0_2_2"/>
    <dbReference type="OrthoDB" id="9883at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052908">
        <property type="term" value="F:16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020598">
        <property type="entry name" value="rRNA_Ade_methylase_Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727:SF7">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00650">
        <property type="entry name" value="rADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA adenine methylase transferase N-terminal" evidence="6">
        <location>
            <begin position="20"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF83168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="239" mass="26818" checksum="ED279D62982A27FA" modified="2014-10-29" version="1">MPRRTKTQALGQHFLADLRVLAKILDASAIGRHETVCEAGTGNGILTKELCRRAKSVVSYEVDRALYAVAKTTLAFSNLELVNADLFKRDEQSFDVFVSNLPYSKSRDAFEWLATREFDRAIVMVQKEFVEKLLAKPGDPNYRAISAIASYCFDIEKLFDVEKECFNPPPLVESTVIRATLKHSMTRETVKNVNRLFSQRNKRASTVAAKLGIRMDFGDKRVDQLVPAQIVALAAGMVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPN6</accession>
    <name>A0A075MPN6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Trypsin-like serine protease with C-terminal PDZ domain</fullName>
            <ecNumber evidence="6">1.3.1.74</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NTE_01021</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1C family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.74" evidence="6"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699926.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPN6"/>
    <dbReference type="STRING" id="1459636.NTE_01021"/>
    <dbReference type="GeneID" id="41596845"/>
    <dbReference type="KEGG" id="nev:NTE_01021"/>
    <dbReference type="eggNOG" id="arCOG02833">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020120_2_0_2"/>
    <dbReference type="OrthoDB" id="350578at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032440">
        <property type="term" value="F:2-alkenal reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051201">
        <property type="entry name" value="Chloro_Bact_Ser_Proteases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43343">
        <property type="entry name" value="PEPTIDASE S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43343:SF3">
        <property type="entry name" value="PROTEASE DO-LIKE 8, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13365">
        <property type="entry name" value="Trypsin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="310"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF83095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="418" mass="43484" checksum="3879B8659A509999" modified="2014-10-29" version="1">MAESSRTPSTTVTMLAILFAGIIIGGVLGAGILTYAPQSLSFWSKPQQAPSAVAQQQQAKTTMTAATTTTTTTVPATPTTADHDLVSLFKQVEGSVVQITSTVSTVNNNIIINGDPLKSESKRLGSGFVYDAQGLIVTNNHVVDGTDTVDVTFTDGNTYSAKVLGKDAYSDLAVIKITDDFTEKLVPLKLGNSTDLQVGDQVVAIGNPFGLSNTMTTGIVSQLGRLIPNEDSTFSIPDVIQTDAAINPGNSGGPLLDMEGEVIGVNSAIQSNTGSFSGIGFAISSSAVQHIVPALIKDGKYDHPWLGIAGTSLTPDLVGKLGLPKNSKGVLITDVTAGGPAQKAGIMGTVFDRFTGDIRRAGDIVTAIDGHEVKRIEDVITYLEQHARPGDAVTLDLNRAGQVVQAHATLEARAGPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQF3</accession>
    <name>A0A075MQF3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQF3"/>
    <dbReference type="STRING" id="1459636.NTE_01700"/>
    <dbReference type="KEGG" id="nev:NTE_01700"/>
    <dbReference type="HOGENOM" id="CLU_1891321_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="134" mass="15475" checksum="8B5543EC24374C8B" modified="2014-10-29" version="1">MICIAMKRISLIDQNHKIFKDVRQILYPPILDNNNDVVDAESRIKAAIEELESAKRPELGGIYNEHIDRRIKLLQNFPKDLNLIENESQKLTNELIENGRKNLSDPAISLERIGLWERLGDLEFLKSILDSPNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQH1</accession>
    <name>A0A075MQH1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Plastocyanin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_01049</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699948.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQH1"/>
    <dbReference type="STRING" id="1459636.NTE_01049"/>
    <dbReference type="GeneID" id="41596872"/>
    <dbReference type="KEGG" id="nev:NTE_01049"/>
    <dbReference type="HOGENOM" id="CLU_1870626_0_0_2"/>
    <dbReference type="OrthoDB" id="3380at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000923">
        <property type="entry name" value="BlueCu_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052721">
        <property type="entry name" value="ET_Amicyanin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36507">
        <property type="entry name" value="BLL1555 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36507:SF1">
        <property type="entry name" value="BLL1555 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00127">
        <property type="entry name" value="Copper-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Blue (type 1) copper" evidence="3">
        <location>
            <begin position="46"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF83122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="136" mass="14793" checksum="B01A55763CEBA6DD" modified="2014-10-29" version="1">MPAAAGLAAGFAFVALFSAWAANPPLYRIDSWIVYAVKIPEGAAAQERNFEPEVIDMKSGSAIRWTNNETAPTTVVIGPACTPSSDVYKATTASRVKLEKQLAPGESFECRFNDMGEYTIHAEPWPWMRGTIKVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQI5</accession>
    <name>A0A075MQI5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01271</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQI5"/>
    <dbReference type="KEGG" id="nev:NTE_01271"/>
    <dbReference type="HOGENOM" id="CLU_181205_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="92" mass="10504" checksum="FCFC1EB9FA096248" modified="2014-10-29" version="1">MWDINGLIDKLLEVHAVEKQQKGVTFTVSFRRFLVCSLRGNQTKAETLEGWRFILADYHYSLVTLSAEEIGATVVLLDYYFQHLKAAAPDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQT6</accession>
    <name>A0A075MQT6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01846</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700592.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQT6"/>
    <dbReference type="STRING" id="1459636.NTE_01846"/>
    <dbReference type="GeneID" id="41597610"/>
    <dbReference type="KEGG" id="nev:NTE_01846"/>
    <dbReference type="eggNOG" id="arCOG08727">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2284913_0_0_2"/>
    <dbReference type="OrthoDB" id="9034at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="101" mass="11424" checksum="90775C64E7FC6899" modified="2014-10-29" version="1">MEYQEHNSSSHSHGELHKEEEHGHGDGEPVIVKRLAPNEMLANDLNEHGIIAETVAQGTHPIESKPCYSHMFGMNSKFTTNKGVIRVRNKNFDLVQVLQKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQU9</accession>
    <name>A0A075MQU9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Trypsin-like serine protease with C-terminal PDZ domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_01520</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQU9"/>
    <dbReference type="STRING" id="1459636.NTE_01520"/>
    <dbReference type="KEGG" id="nev:NTE_01520"/>
    <dbReference type="eggNOG" id="arCOG02833">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1691596_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06779">
        <property type="entry name" value="cpPDZ_Deg_HtrA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051201">
        <property type="entry name" value="Chloro_Bact_Ser_Proteases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43343">
        <property type="entry name" value="PEPTIDASE S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43343:SF3">
        <property type="entry name" value="PROTEASE DO-LIKE 8, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="40"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF83583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="165" mass="17494" checksum="AB2C2B6FCF802F94" modified="2014-10-29" version="1">MLSAPVWKYFVAHSLASTVAAFAILFVIVGISFAYVSANPVTVQNNPQTEQRPWTGISGSNLTPAIAKAMGTNEQSGFLVVEVAPNSPAEKAGIKGGDRAVTVDGRQVLVGGDIIIEVDGQPVTGFTDIQQHFQQKHVGDTMRFTVVRGSVTMQIPVVLEESPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQV3</accession>
    <name>A0A075MQV3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00289</name>
        <name evidence="3" type="ORF">NTE_01139</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQV3"/>
    <dbReference type="STRING" id="1459636.NTE_00289"/>
    <dbReference type="KEGG" id="nev:NTE_00289"/>
    <dbReference type="KEGG" id="nev:NTE_01139"/>
    <dbReference type="eggNOG" id="arCOG02751">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055957_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:DNA transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase IS4-like" evidence="1">
        <location>
            <begin position="153"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF83212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="345" mass="40164" checksum="F543D1C866050933" modified="2014-10-29" version="1">MTKRSKHKRRKVTTYLEDRRQLRMTQFPSDKRQTYAQNWKAYDDAQCGEQDTFLKLLSDLCRNVDQPAYDFGRPRLPLSDMVFASALKVYSTFSLRRFMSQMQKAVAEGHVDTFCSYSSVSNYMRKKELTPILYELIKLSSLPLASVETTFGVDSSGFGTSSRFARYFDFKHGKDKKYKKWVKAHICCGLKTNVITAVQLTDGDRPDHPYFQPLLEKTAQSFNLKEAVADKAYLSRTNLQFVEDLGGKPFIPFKVNSRGLAIGAPAWNRMYHYFNLHRDDFMKHYHKRSNVETAFHMIKTKFREYVRSKDETAQFNEVLLKILCHNICVVIQEIHELGIRADFSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MR44</accession>
    <name>A0A075MR44_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytosine/adenosine deaminase</fullName>
            <ecNumber evidence="4">3.5.4.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_01507</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.4.1" evidence="4"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700318.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MR44"/>
    <dbReference type="STRING" id="1459636.NTE_01507"/>
    <dbReference type="GeneID" id="41597296"/>
    <dbReference type="KEGG" id="nev:NTE_01507"/>
    <dbReference type="eggNOG" id="arCOG01488">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_681275_0_0_2"/>
    <dbReference type="OrthoDB" id="10653at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004131">
        <property type="term" value="F:cytosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="3">
        <location>
            <begin position="14"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF83570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="405" mass="44521" checksum="B788192D353B22F1" modified="2014-10-29" version="1">MNRNDSGVSLLAEKCAGIATEEAEKAAARGTFGVGGLLIENSTGKVLKKVPNRVIVRDTVVDPTAHVEKQLVDWYYLSKSSLPLAADMTIICSLDPCIMCTGAILRSGLNVIRISDDSECGVSCWGQNDLTTLPAELRQEKAARFSAFGLRGNKRAFAGSQGSIFSGIEIDPLFEKRSTKAFRSSLDKIRKSINKDWIFSPDSLENPRSLAKSKPLSRVVKTIKRYNPDAFSEKHTLDRGASCTALGHVLVDKARESHRYTGLFNSACIIDPFGNILLAGGANPVEQTPLLDIMRKYHSLVNDAGKNGKRYLAHPKYCKVAIFFGPARDPTGMMEVGSLGSFFEGKLPKESRGQLEYVLPRQDASELADMLRNLPPFYSETVNLKNVIQQTQDDALKEFCKARIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRA9</accession>
    <name>A0A075MRA9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Succinyl-CoA synthetase (ADP-forming) beta subunit</fullName>
            <ecNumber evidence="7">6.2.1.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NTE_02034</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.2.1.5" evidence="7"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700731.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRA9"/>
    <dbReference type="STRING" id="1459636.NTE_02034"/>
    <dbReference type="GeneID" id="41597775"/>
    <dbReference type="KEGG" id="nev:NTE_02034"/>
    <dbReference type="eggNOG" id="arCOG01337">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037430_0_2_2"/>
    <dbReference type="OrthoDB" id="146449at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042709">
        <property type="term" value="C:succinate-CoA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006104">
        <property type="term" value="P:succinyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013650">
        <property type="entry name" value="ATP-grasp_succ-CoA_synth-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017866">
        <property type="entry name" value="Succ-CoA_synthase_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005809">
        <property type="entry name" value="Succ_CoA_ligase-like_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815:SF10">
        <property type="entry name" value="SUCCINATE--COA LIGASE [GDP-FORMING] SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815">
        <property type="entry name" value="SUCCINYL-COA SYNTHETASE BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08442">
        <property type="entry name" value="ATP-grasp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001554">
        <property type="entry name" value="SucCS_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01217">
        <property type="entry name" value="SUCCINYL_COA_LIG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="6">
        <location>
            <begin position="9"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF84091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="369" mass="39557" checksum="D7E497F8F0374BCE" modified="2014-10-29" version="1">MRLLEYQGKELFDQYGIRIPRSYLANSLSEAREGAKKLGYPFVLKSQLTVGGRGKAGAILKCKTEAELEPKFTELVHKEVKGELPRGILLEEMADIKKELYLSLFLNRSKRCYSLIASAEGGVEIESTGNKVVVDVPIGGISPQVAEDTAGRLGLTGNAAVAFVDLATKLSRMAGEKEAELAEINPVAILGDGSMLALDAKVIIDDNAMFRHPELKKYEHVSELEKQAEESGFSLVELDGNIAIIGNGAGLVMSTLDLVSDAGGKAGTFLDFGGRATTETIYEALTVISKIKRVQAILVNLFGGIVRTDLVAQAIIDAYKNNIIAVPVFARISGAESEKARQMLNGSKAKLYPTVEEAIQAAVAAVGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRM8</accession>
    <name>A0A075MRM8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein S3AE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_01757</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700520.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRM8"/>
    <dbReference type="STRING" id="1459636.NTE_01757"/>
    <dbReference type="GeneID" id="41597527"/>
    <dbReference type="KEGG" id="nev:NTE_01757"/>
    <dbReference type="eggNOG" id="arCOG04186">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062507_1_0_2"/>
    <dbReference type="OrthoDB" id="30639at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001593">
        <property type="entry name" value="Ribosomal_eS1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01015">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01397">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF83818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="236" mass="26502" checksum="A9847ED9F769F4E7" modified="2014-10-29" version="1">MVKAAKKGGRVRDKWRDKQWVIVNKPSGFEPPGSVNYVPITDGEQAKGRVIENTLHDMMKGNPDQTMDQHQIKIFIQIDRISDGTASTRFKGHEYAKEFLRSLIRRGSSMVNFVHDYTTQDGHTFRVAVVAFTQRRVNASKKHEIRMIAHRILSEKIPQMTVEQFVQETTGSKAGDIPRETNSLLGAVIMDEAKKISNIRHLGIKKTKLISTPESRAVSDAKPVEATTTVAEPAPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MS14</accession>
    <name>A0A075MS14_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Transcription regulator AsnC/Lrp ligand binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02252</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MS14"/>
    <dbReference type="KEGG" id="nev:NTE_02252"/>
    <dbReference type="eggNOG" id="arCOG01117">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2893046_0_0_2"/>
    <dbReference type="OrthoDB" id="377711at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription regulator AsnC/Lrp ligand binding" evidence="1">
        <location>
            <begin position="2"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="62" mass="6691" checksum="FE42B0409D3B7699" modified="2014-10-29" version="1">MRAISGVSEATGVSGIYDIVAKLHTDSNDGIMGIVRKFHLIANVRSCLTMIVAGELDNWQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MS88</accession>
    <name>A0A075MS88_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MIP family channel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NTE_01609</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700400.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MS88"/>
    <dbReference type="STRING" id="1459636.NTE_01609"/>
    <dbReference type="GeneID" id="41597387"/>
    <dbReference type="KEGG" id="nev:NTE_01609"/>
    <dbReference type="eggNOG" id="arCOG04431">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020019_3_4_2"/>
    <dbReference type="OrthoDB" id="36050at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00861">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139">
        <property type="entry name" value="AQUAPORIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139:SF199">
        <property type="entry name" value="MIP17260P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="86"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF83672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="244" mass="25631" checksum="DBF3962976405108" modified="2014-10-29" version="1">MVNPRAWLAEAIGTYALVFFGPLAITIAIAMFGLSMGPDALLIISFAHGAVIGLMVYVFGHVSGTHINPAVTIAMMATRRINVKDGAAYIAFQLIGAVAASATLAAIIPTYASQVNYGVQGGPSEFLNNSAASGFAVEAILTFFLLTTIFMVAVHKKAAAGFAGIAIGGMIFLLHLVGVPLTGASMNPARTFGPALVSGHWDFHWIYWAGPIVGALVAAFIMNYIFVKKAEKEETEAPRAEKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSC3</accession>
    <name>A0A075MSC3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cation diffusion facilitator family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NTE_02426</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385456.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSC3"/>
    <dbReference type="STRING" id="1459636.NTE_02426"/>
    <dbReference type="GeneID" id="41598135"/>
    <dbReference type="KEGG" id="nev:NTE_02426"/>
    <dbReference type="eggNOG" id="arCOG01474">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013430_3_3_2"/>
    <dbReference type="OrthoDB" id="8907at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="entry name" value="Cation efflux protein, cytoplasmic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050291">
        <property type="entry name" value="CDF_Transporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840:SF15">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="7">
        <location>
            <begin position="15"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="8">
        <location>
            <begin position="229"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF84476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="287" mass="31534" checksum="A0E1B713B5AE957F" modified="2014-10-29" version="1">MDKSAVFDEARKAAWVSIWTLIAIGVAEVLLSFFTNSLTLFADGLDSLADALVSFVVWFGIRMIHRPKSRLFPFGYTKIESFAAFVAAVIILFLGGSIVYNAYQHFLHPEPVGNYPVTMAALAGAGAVSLHRAFKVRSVAKKYDLISLNLDAKNSIKDGTASFVGLASVIAAFFGIPYMDAIGSIMIAGYIFYMAFTALKESALVLVDAVKNPEMQAEMIAHIEKKFSVRVEKILLRPAGQEFYAQVHVELDKNMSLDKANELMSKIRASVMSEFETEDTVVIPKPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSE2</accession>
    <name>A0A075MSE2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Formate hydrogenlyase subunit 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NTE_02451</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701066.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSE2"/>
    <dbReference type="STRING" id="1459636.NTE_02451"/>
    <dbReference type="GeneID" id="41598158"/>
    <dbReference type="KEGG" id="nev:NTE_02451"/>
    <dbReference type="eggNOG" id="arCOG01545">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015134_2_0_2"/>
    <dbReference type="OrthoDB" id="15253at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052561">
        <property type="entry name" value="ComplexI_Subunit1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001694">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su1/FPO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43359">
        <property type="entry name" value="FORMATE HYDROGENLYASE SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43359:SF1">
        <property type="entry name" value="FORMATE HYDROGENLYASE SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00146">
        <property type="entry name" value="NADHdh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF84501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="315" mass="33585" checksum="B27B47FAAA9643B5" modified="2014-10-29" version="1">MAEALTIAVGIAQTSAIVALAPLLTGVMRKVKARTQKRVGASVLQPYYDLAKLMKKDEVVSDQSSWVFRSAPWVVMVAMITAALFVPAFLPFSPFGTVGDILVVLGLFGLARFFTMLVGLDVASTFGGLGASREMMISSLTEPALFLTIFVVSLSLGGTNLSSLVGAAAQYAGFAEAPSMLFALIAFFIVLLAETGRLPFDNPATHLELTMVHEAMVLEYSGKSLAMVQWSQSIKQLLLFALLVNLFIPAGIPASLDSGWSVAAGAAGFVAKVVLLAMLVAYVETRAAKWRLFRVPDLLAMAIASSMIGVIFFYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSE5</accession>
    <name>A0A075MSE5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BirA, biotin-(Acetyl-CoA-carboxylase) ligase</fullName>
            <ecNumber evidence="5">6.3.4.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_01982</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.3.4.15" evidence="5"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700692.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSE5"/>
    <dbReference type="STRING" id="1459636.NTE_01982"/>
    <dbReference type="GeneID" id="41597730"/>
    <dbReference type="KEGG" id="nev:NTE_01982"/>
    <dbReference type="eggNOG" id="arCOG01940">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051096_0_0_2"/>
    <dbReference type="OrthoDB" id="46252at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004077">
        <property type="term" value="F:biotin--[biotin carboxyl-carrier protein] ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16442">
        <property type="entry name" value="BPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00978">
        <property type="entry name" value="Bifunct_BirA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030855">
        <property type="entry name" value="Bifunct_BirA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004408">
        <property type="entry name" value="Biotin_CoA_COase_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003142">
        <property type="entry name" value="BPL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008988">
        <property type="entry name" value="Transcriptional_repressor_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00121">
        <property type="entry name" value="birA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12835">
        <property type="entry name" value="BIOTIN PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12835:SF5">
        <property type="entry name" value="BIOTIN--PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02237">
        <property type="entry name" value="BPL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50037">
        <property type="entry name" value="C-terminal domain of transcriptional repressors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="4">
        <location>
            <begin position="79"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF84040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="349" mass="38105" checksum="DF999E3B5AE7DDA5" modified="2014-10-29" version="1">MVRVAQSGDNSYHRLQEFLELLKKSQDFASGQSLAKRAGISRSAVWKQVRGLRQYGYKIESLHGKGYRLAGGTTHPVPWELAKILKTSFVGKGRIVYRDSADSTQNIAIALAEKHEDVHGAVVIAEQQVSGRGRMKRKWLSPRGGVWVSVVLKPPVPTAASTMLPFVAALAVCDAVRQETGLLATLKWPNDVMINGKKTAGILVDISAEAETVNYAVIGIGINANVDTSRIKNTIVGDRRGRPAITSLKEELGHDVNRLELARLLFEHLERFYGMLLESGGPEKIVAEWRRRSDMLGKKVSVAQAQHGKASSFVDGIAADINDDGSLLIETESGTTVNVVSGDVHVMRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSE7</accession>
    <name>A0A075MSE7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02456</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSE7"/>
    <dbReference type="KEGG" id="nev:NTE_02456"/>
    <dbReference type="HOGENOM" id="CLU_2629855_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="80" mass="9147" checksum="3BEF70098B3DFC2F" modified="2014-10-29" version="1">MEVNDATTEETVNDVPSKQTRVRINTEIEGEPAKILLELKQRGLVSDNTDAVNQGLLVLYDRVLKRDMARLQLQRLKEVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSF4</accession>
    <name>A0A075MSF4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protoheme IX farnesyltransferase</fullName>
            <ecNumber evidence="11">2.5.1.141</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Heme B farnesyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Heme O synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ctaB</name>
        <name evidence="12" type="ORF">NTE_01661</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>heme b + (2E,6E)-farnesyl diphosphate + H2O = Fe(II)-heme o + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:28070"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:60530"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.141"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Porphyrin-containing compound metabolism; heme O biosynthesis; heme O from protoheme: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Cell membrane</location>
            <topology evidence="2 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="11">Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.141" evidence="11"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700441.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSF4"/>
    <dbReference type="STRING" id="1459636.NTE_01661"/>
    <dbReference type="GeneID" id="41597436"/>
    <dbReference type="KEGG" id="nev:NTE_01661"/>
    <dbReference type="eggNOG" id="arCOG00479">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029631_0_1_2"/>
    <dbReference type="OrthoDB" id="131615at2157"/>
    <dbReference type="UniPathway" id="UPA00834">
        <property type="reaction ID" value="UER00712"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008495">
        <property type="term" value="F:protoheme IX farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048034">
        <property type="term" value="P:heme O biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13957">
        <property type="entry name" value="PT_UbiA_Cox10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00154">
        <property type="entry name" value="CyoE_CtaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006369">
        <property type="entry name" value="Protohaem_IX_farnesylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030470">
        <property type="entry name" value="UbiA_prenylTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01473">
        <property type="entry name" value="cyoE_ctaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003349">
        <property type="entry name" value="PRK04375.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448">
        <property type="entry name" value="PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448:SF2">
        <property type="entry name" value="PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00943">
        <property type="entry name" value="UBIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 11" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIF83722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="299" mass="32887" checksum="8C142A4DFD81B56A" modified="2014-10-29" version="1">MTARDFVEVSKPRIVVVLVITAVTSYLAATRFDATPSVAWDVDWFKLGFLTLAGALASMGASALNHYYDRDIDKVMERTAKRPIPAGRLSPKSVLAYGLGVSVLSVVIAWFTLNPMATGMIALGIFFYVIIYTAWLKRNNAWNIVIGGFAGSAASMAGWATVTGSMDLLGFLVGWLVFMWTPPHFWCLAIRAREEYASVRVPMLPVLIGNQKTASYILANTAILLPYSVGLYFLNPGPGLLYTIIAAISGSLMLIYHYKLTKNPTPEFAWKAYKVTAPYLVVIFVALAVDALFYYKIPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSJ1</accession>
    <name>A0A075MSJ1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02497</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701101.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSJ1"/>
    <dbReference type="GeneID" id="41598201"/>
    <dbReference type="KEGG" id="nev:NTE_02497"/>
    <dbReference type="HOGENOM" id="CLU_2874905_0_0_2"/>
    <dbReference type="OrthoDB" id="13672at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="63" mass="7300" checksum="421CAF6BBF4F529C" modified="2014-10-29" version="1">MSTANSAEFLTTTTVEDDFSYDRRKLTELGVNTEFLKFMNDEQARELLKSLLYLIVKKQDGYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MT40</accession>
    <name>A0A075MT40_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">3-isopropylmalate dehydratase</fullName>
            <ecNumber evidence="6">4.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Alpha-IPM isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Isopropylmalate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">NTE_02327</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterodimer of LeuC and LeuD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the LeuD family. LeuD type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="6"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700961.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MT40"/>
    <dbReference type="STRING" id="1459636.NTE_02327"/>
    <dbReference type="GeneID" id="41598043"/>
    <dbReference type="KEGG" id="nev:NTE_02327"/>
    <dbReference type="eggNOG" id="arCOG02230">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081378_0_3_2"/>
    <dbReference type="OrthoDB" id="6505at2157"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009316">
        <property type="term" value="C:3-isopropylmalate dehydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01577">
        <property type="entry name" value="IPMI_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.19.10:FF:000003">
        <property type="entry name" value="3-isopropylmalate dehydratase small subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01031">
        <property type="entry name" value="LeuD_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004431">
        <property type="entry name" value="3-IsopropMal_deHydase_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033940">
        <property type="entry name" value="IPMI_Swivel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050075">
        <property type="entry name" value="LeuD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00171">
        <property type="entry name" value="leuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002458">
        <property type="entry name" value="PRK01641.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43345:SF5">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDRATASE SMALL SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43345">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDRATASE SMALL SUBUNIT 2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="9 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="13">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AIF84380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="196" mass="22507" checksum="ADB776B02F106493" modified="2014-10-29" version="1">MEPFTVLKSKATPLDRVNVDTDQIVPKQFLKLVSRSGFGQYLFYDWRFDAEGRPRPDFVLNDPKYKGRQILLARDNFGSGSSREHAAWAILDYGFRAVVAPSFADIFYNNCFKNGVLPVRLAAQEVDYLFQDDGLEIEIDLAKQTVRAGQKEMHFEIDDFRKKLLLEGLDSIGLTLKLDSEISKYERQRQTFAPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MT95</accession>
    <name>A0A075MT95_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SprT-like family</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02734</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701291.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MT95"/>
    <dbReference type="STRING" id="1459636.NTE_02734"/>
    <dbReference type="GeneID" id="41598424"/>
    <dbReference type="KEGG" id="nev:NTE_02734"/>
    <dbReference type="eggNOG" id="arCOG11830">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1682759_0_0_2"/>
    <dbReference type="OrthoDB" id="10518at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="156" mass="18274" checksum="9DDC5C0A7D1CD612" modified="2014-10-29" version="1">MLRFTRVAEAKFSGEFQERVLKVYGLFPELAEHDIKCGYIRKGMRLLGTARGWTTPKQISLQPNVGRMTIAHELTHLLQGSDGVPHGEKACDIWAVARLPAEMLDEQPYYLLRHWHRERWLRNRVQAKALCERAIGVRRTERNYIKWLSGELRHLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTB8</accession>
    <name>A0A075MTB8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">OBG-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_01984</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700694.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTB8"/>
    <dbReference type="STRING" id="1459636.NTE_01984"/>
    <dbReference type="GeneID" id="41597732"/>
    <dbReference type="KEGG" id="nev:NTE_01984"/>
    <dbReference type="eggNOG" id="arCOG00357">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037276_1_0_2"/>
    <dbReference type="OrthoDB" id="5875at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006074">
        <property type="entry name" value="GTP1-OBG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013646">
        <property type="entry name" value="YGR210-like_G4"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007171">
        <property type="entry name" value="PRK09602.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305">
        <property type="entry name" value="OBG GTPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305:SF1">
        <property type="entry name" value="OBG-TYPE G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08438">
        <property type="entry name" value="YGR210-like_G4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00905">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="3">
        <location>
            <begin position="2"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF84042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="403" mass="44581" checksum="974C58729673AC05" modified="2014-10-29" version="1">MIKIGLIGKTNTGKTTFFNSATLASAEISNYPFTTKQANIGNAHAITVCVHKEFGVQDNPKNSRCIDGWRFIPVELVDLPGLIKGAWEGKGLGNQFLSIAAQSDALLHIVDASGSIDASGKIAEPGSGDPVADVGDIEEELVMWYLKLFEANRDKISRNVDSGIEPVAAITEVFRGIGVREDHVQMALAQNNLASVPLDDFGPQQSKDFCWSLRDISKPTLIVANKVDLPTATDNFRRLREEYKDMIVVPSSADAELTLRRAESRGLIRYIPGDERFEINEQTPLNDKQKWALNFIRKDILGEYMRTGVQFAINVAVFKLLKMNAVYPVADAKKMSDKHGNVLPDVYLMRSGSTVEDLAREIHSELAKGLLYALDARDGLHLPTNYHLKDRDVLSIVSAKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTC1</accession>
    <name>A0A075MTC1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative translation initiation inhibitor, yjgF family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701027.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTC1"/>
    <dbReference type="STRING" id="1459636.NTE_02403"/>
    <dbReference type="GeneID" id="41598114"/>
    <dbReference type="KEGG" id="nev:NTE_02403"/>
    <dbReference type="eggNOG" id="arCOG01630">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104845_0_1_2"/>
    <dbReference type="OrthoDB" id="371655at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd02199">
        <property type="entry name" value="YjgF_YER057c_UK114_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013813">
        <property type="entry name" value="Endoribo_LPSP/chorism_mut-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43760:SF1">
        <property type="entry name" value="ENDORIBONUCLEASE L-PSP_CHORISMATE MUTASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43760">
        <property type="entry name" value="ENDORIBONUCLEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14588">
        <property type="entry name" value="YjgF_endoribonc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endoribonuclease L-PSP/chorismate mutase-like" evidence="1">
        <location>
            <begin position="13"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="159" mass="16357" checksum="60F59D37319F5F58" modified="2014-10-29" version="1">MTTTSSTTAAEQTLKSLGITLPTPPAPAGSYVPVVVSGNLAFVAGQIPVEAGQVKFKGKVGRDVSIEAGQQAARLCTINAVAQLKAALGSLGRIKRIVKVTGFVNCEPSFADQPKVINGASDLLVQIFGESGKHARAAVGVSSLPLESAVEVEFIVEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTC7</accession>
    <name>A0A075MTC7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative flavin-nucleotide-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTC7"/>
    <dbReference type="STRING" id="1459636.NTE_02410"/>
    <dbReference type="KEGG" id="nev:NTE_02410"/>
    <dbReference type="eggNOG" id="arCOG00520">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067890_2_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024747">
        <property type="entry name" value="Pyridox_Oxase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34071">
        <property type="entry name" value="5-NITROIMIDAZOLE ANTIBIOTICS RESISTANCE PROTEIN, NIMA-FAMILY-RELATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34071:SF2">
        <property type="entry name" value="FLAVIN-NUCLEOTIDE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12900">
        <property type="entry name" value="Pyridox_ox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="218" mass="24731" checksum="AB8DC9545239D434" modified="2014-10-29" version="1">MCTAEAYMQLVKKFEIKSRDKIIDFLNSQPVGRVASIDKNGYPQVIPMNFVWSEGAVYMHSHPMGEKLENMLRDPKVGFEVDQHVCFLPSYYFHPTDASQADTLYISVVIKGRAVLVSDGNEKARALNALMEKYQKEGRYEPLAAEMPVVHEVAIIKIIPDEMRGKYKIGQHWSRPYRLKMAQNIIEREGLENAKPILAIMGIETKNGAPEAASELEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTF7</accession>
    <name>A0A075MTF7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701052.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTF7"/>
    <dbReference type="STRING" id="1459636.NTE_02435"/>
    <dbReference type="GeneID" id="41598143"/>
    <dbReference type="KEGG" id="nev:NTE_02435"/>
    <dbReference type="eggNOG" id="arCOG03008">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_149791_1_1_2"/>
    <dbReference type="OrthoDB" id="190812at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-2" evidence="1">
        <location>
            <begin position="37"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="105" mass="12001" checksum="8CAE452D1F004AA7" modified="2014-10-29" version="1">MKEKGQAFDLDDLLTKIDKDSYWVDFIKIRHLEAGVLRLYPNEEDTQTPHDADELYFVVEGSGFISMGKESKAVKKGSVLFVPAGMPHHFYGNRNTLVVLYMFAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTF8</accession>
    <name>A0A075MTF8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phage protein D</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00503</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699531.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTF8"/>
    <dbReference type="STRING" id="1459636.NTE_00503"/>
    <dbReference type="GeneID" id="41596376"/>
    <dbReference type="KEGG" id="nev:NTE_00503"/>
    <dbReference type="HOGENOM" id="CLU_730987_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69279">
        <property type="entry name" value="Phage tail proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="379" mass="41469" checksum="A5596756C596D47E" modified="2014-10-29" version="1">MEGLTNVYVILMAGPTIPTPVPEAVASAVESIEVTNRDIAPDGFEIIFNVGRSRQDLQDYALIANPLLNPFNQVRIIVTFGGIQTNLINGIITTKQLSPSQQPGQTRMVVTGEDLSFFMSKDESPTTHSSLDDKSIVEKIIAKYTQHGIEPDIHEVQSPVRHPEADQVPSQQSTDLDHIKDLARKYNYVFFLEPALLTNKSRAYWGPRKYTGAPQKALTLDMGSESNLKAISFQYNVTEPTIVTGKTVDIVTNKEVPVTVTGSSLPPLSLYPVLSMQASRVQKKKYNRSSASAAQAMSEAQAETDESTDAVIATGTLDSLAYGGVLQARKLVGLRGVGFLHDGYYYVKEVKHEIKKGEYKQSFKLVRDGLGSTASVLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTL0</accession>
    <name>A0A075MTL0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Putative asparagine synthetase [glutamine-hydrolyzing]</fullName>
            <ecNumber evidence="9">6.3.5.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">NTE_02481</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>L-aspartate + L-glutamine + ATP + H2O = L-asparagine + L-glutamate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12228"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.4" evidence="9"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701088.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTL0"/>
    <dbReference type="STRING" id="1459636.NTE_02481"/>
    <dbReference type="GeneID" id="41598186"/>
    <dbReference type="KEGG" id="nev:NTE_02481"/>
    <dbReference type="eggNOG" id="arCOG00071">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG00093">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014658_4_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00712">
        <property type="entry name" value="AsnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006426">
        <property type="entry name" value="Asn_synth_AEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050795">
        <property type="entry name" value="Asn_Synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033738">
        <property type="entry name" value="AsnB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01536">
        <property type="entry name" value="asn_synth_AEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11772">
        <property type="entry name" value="ASPARAGINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11772:SF2">
        <property type="entry name" value="ASPARAGINE SYNTHETASE [GLUTAMINE-HYDROLYZING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001589">
        <property type="entry name" value="Asn_synthetase_glu-h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="4 9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="1 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 9 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="12">
        <location>
            <begin position="2"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="10">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIF84530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="546" mass="60699" checksum="4F8A6F135DFAD180" modified="2014-10-29" version="1">MCGIAGVLSKRGENVAPLVGSMLFSMASRGPDGAGVSFEGQVIRSQSVADLDLGAMRAQSVIGHSRLAIVGGTCGTQPFRSCDGRLTLEHNGEIYNYKELRARLEGRHAFSTETDSEVIVHLLEEHYNSCRDLLGAVRRTVAELDGVYALAIRDEATDTTVLARDRLGVRPMYYAENERMVAFASERKALWAVGLKEPTLRVLPGHALVIENARTKPQVQVAGLLKAKVLHRTVASAVAAYEDALVAAMKKRTQDVQRIGIIFSGGIDSVLVAYLASKMVPEVICYTCGVEGSSDLEFARQIADTLGLKLRVNELSQDRVEQLAPELIRVIEESNAGQIEVALPVYGAVELAKQDGIRIMLTGQGADELFAGYNWYSCVAEREGYRKLRKRMAQDLSLLYKETLEREDKITMAHSIELREPYLDLYVIKASMEIDLRLNVRPGDRFGKRIHRKLAEKLGIPHDVAFRIKEAAQHGSGMHDMLEAVARKNGFDEEAITARYLSELQLKEKMGSSQRYGYLFEKESKMWVAEPHVQMYLDSIVHKKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTN0</accession>
    <name>A0A075MTN0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NTE_02940</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701457.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTN0"/>
    <dbReference type="STRING" id="1459636.NTE_02940"/>
    <dbReference type="GeneID" id="41598618"/>
    <dbReference type="KEGG" id="nev:NTE_02940"/>
    <dbReference type="eggNOG" id="arCOG02376">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_2_2"/>
    <dbReference type="OrthoDB" id="342253at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047:SF72">
        <property type="entry name" value="OSMOSENSING HISTIDINE PROTEIN KINASE SLN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="8">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="148"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="114"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF84976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="378" mass="41385" checksum="C73718E829226510" modified="2014-10-29" version="1">MQRRTSDFAENVPLLICFIGPDGRITDANSYFVQATGFSKDELTGMQVFDIVTQRAGTIKETIATIISSRQASVKEIDVLVRRKDGTEFPGILAASALPQQDNSSSESKVIGVAVTESSQLARAKEEAEAANKELRRKESLKDEFIAIASHELRTPIQPILGLALLAKKGQISQEEAWDSVLKEARRLTQLANDILDVSRIENGTLRYNFARANVSEIIEYVVNALRTSELGKDIDFSIVMDESARAAYCDLDRQRITQVLMNVIGNAAKFTIKGRVNIEARADVKNSRYDIMVSDTGGGIPEAVLPHMFKKFITKSVGEGEKHGSGLGLFISRAIIAAHNGAIYLYNNDENGATFVIRLPFEQPAARRALSSPPPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTW4</accession>
    <name>A0A075MTW4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl2</name>
        <name evidence="8" type="ORF">NTE_03051</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701550.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
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    <dbReference type="STRING" id="1459636.NTE_03051"/>
    <dbReference type="GeneID" id="41598719"/>
    <dbReference type="KEGG" id="nev:NTE_03051"/>
    <dbReference type="eggNOG" id="arCOG04067">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036235_0_1_2"/>
    <dbReference type="OrthoDB" id="5987at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="entry name" value="Ribosomal protein L2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01320_A">
        <property type="entry name" value="Ribosomal_uL2_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_uL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023672">
        <property type="entry name" value="Ribosomal_uL2_arc_euk"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_uL2_C"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ribosomal_uL2_RNA-bd_dom"/>
    </dbReference>
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        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
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        <property type="entry name" value="PRK09612.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="RIBOSOMAL PROTEIN L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002158">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL2 RNA-binding" evidence="7">
        <location>
            <begin position="11"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL2 C-terminal" evidence="6">
        <location>
            <begin position="89"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="203"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF85086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="246" mass="26100" checksum="4B886E3EE4A84F97" modified="2014-10-29" version="1">MGKRTLVRRRGRGGKQFRAIIVGKIAPAKYPNFKLEENHKGTVVDIVHERGRDAPLAKVSFDDGRHSYVPAPEGTIVGSTIQVGQGSPATKGNILALESVPDGTLVCNIEKNAGDGGKLIKAAGSGAIVFAHGTEGVTIKFPSGKFLTLNAKCRAMIGTIAGAGRKEKPFLKAGNRAKYMQAHGRLYPTVRGIAQAAVYHPHGGGRHQHIGRQSSVSRNTPPGRKVGNIAPKKTGRGRIKEVPQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MU18</accession>
    <name>A0A075MU18_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00689</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385041.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MU18"/>
    <dbReference type="STRING" id="1459636.NTE_00689"/>
    <dbReference type="GeneID" id="43502575"/>
    <dbReference type="KEGG" id="nev:NTE_00689"/>
    <dbReference type="HOGENOM" id="CLU_3162928_0_0_2"/>
    <dbReference type="OrthoDB" id="7794at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="47" mass="5425" checksum="B46D5621983C436A" modified="2014-10-29" version="1">MSTKPDEGKLSEGTIMDIEQSLEDAKADRTLSMKEVKERFKLNDDFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MU27</accession>
    <name>A0A075MU27_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">5-formyltetrahydrofolate cyclo-ligase</fullName>
            <ecNumber evidence="4">6.3.3.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_02168</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.2" evidence="4"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MU27"/>
    <dbReference type="STRING" id="1459636.NTE_02168"/>
    <dbReference type="KEGG" id="nev:NTE_02168"/>
    <dbReference type="eggNOG" id="arCOG00474">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066245_1_1_2"/>
    <dbReference type="OrthoDB" id="18307at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030272">
        <property type="term" value="F:5-formyltetrahydrofolate cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009396">
        <property type="term" value="P:folic acid-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002698">
        <property type="entry name" value="FTHF_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02727">
        <property type="entry name" value="MTHFS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23407:SF1">
        <property type="entry name" value="5-FORMYLTETRAHYDROFOLATE CYCLO-LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23407">
        <property type="entry name" value="ATPASE INHIBITOR/5-FORMYLTETRAHYDROFOLATE CYCLO-LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01812">
        <property type="entry name" value="5-FTHF_cyc-lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006806">
        <property type="entry name" value="FTHF_cligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF84222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="172" mass="19099" checksum="1DB83F0DD61E36F5" modified="2014-10-29" version="1">MARRDALAPLDIEQQSVLVQESVAQSKEFEQAQVIGAYYPKGSEVRTALLIGIAKDQGKKVALPRTEGSDMRFYEYEPADKLVQGNFGIMEPAPKRLVQHIDLVLVPGVAFDRKGCRIGYGKGYYDRFISEGRSSFSMGLAYSIQIVNEGLPSGRLDRKLDALATENGIMYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MU36</accession>
    <name>A0A075MU36_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zn-dependent oxidoreductase, NADPH:quinone reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_03144</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701620.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MU36"/>
    <dbReference type="STRING" id="1459636.NTE_03144"/>
    <dbReference type="GeneID" id="41598803"/>
    <dbReference type="KEGG" id="nev:NTE_03144"/>
    <dbReference type="eggNOG" id="arCOG01458">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_3_3_2"/>
    <dbReference type="OrthoDB" id="146629at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05289">
        <property type="entry name" value="MDR_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050700">
        <property type="entry name" value="YIM1/Zinc_Alcohol_DH_Fams"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695:SF294">
        <property type="entry name" value="RETICULON-4-INTERACTING PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="13"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF85176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="315" mass="33864" checksum="38AB66C977119581" modified="2014-10-29" version="1">MKSVRIKGYGSTGDVIEIDQNTPAPNDPSEGKVLVKVKAAGVNPTDWKISEGYMQQIMPIEFPATLGWDFSGTVEKAGAGLSDIKQGDEVYGQAAAVFGGSGTFAEMALANADNIAQKPKTLSHEEAAGLPTVGVTAWQALVDIIGLSKGQKILIHGGAGGVGSIAIQLAKYLGAYVATTVGEKDKQFVKGLGADEIIDYKTQTFEDLLSHDYNAVLDTVGGETYTRSFKILKRGTEIIVSTLEQPNQELMEKFGVKAIFVFSQVNRERLTKLAQWVDENNVRVNVDKTFPLDDAAKALDHQRVAHPRGKVVLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MU65</accession>
    <name>A0A075MU65_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Adenosine 5'-phosphosulfate reductase</fullName>
            <ecNumber evidence="9">1.8.4.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">5'-adenylylsulfate reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Thioredoxin-dependent 5'-adenylylsulfate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">NTE_02662</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of sulfite from adenosine 5'-phosphosulfate (APS) using thioredoxin as an electron donor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>[thioredoxin]-disulfide + sulfite + AMP + 2 H(+) = adenosine 5'-phosphosulfate + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:21976"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="1.8.4.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.10" evidence="9"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701229.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MU65"/>
    <dbReference type="STRING" id="1459636.NTE_02662"/>
    <dbReference type="GeneID" id="41598354"/>
    <dbReference type="KEGG" id="nev:NTE_02662"/>
    <dbReference type="eggNOG" id="arCOG00124">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044089_1_0_2"/>
    <dbReference type="OrthoDB" id="14887at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043866">
        <property type="term" value="F:adenylyl-sulfate reductase (thioredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004604">
        <property type="term" value="F:phosphoadenylyl-sulfate reductase (thioredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019379">
        <property type="term" value="P:sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23945">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00063">
        <property type="entry name" value="CysH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011798">
        <property type="entry name" value="APS_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004511">
        <property type="entry name" value="PAPS/APS_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02055">
        <property type="entry name" value="APS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00434">
        <property type="entry name" value="cysH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002537">
        <property type="entry name" value="PRK02090.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46482:SF9">
        <property type="entry name" value="5'-ADENYLYLSULFATE REDUCTASE 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46482">
        <property type="entry name" value="5'-ADENYLYLSULFATE REDUCTASE 3, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000857">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoadenosine phosphosulphate reductase" evidence="14">
        <location>
            <begin position="37"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AIF84705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="247" mass="28283" checksum="D2C39BFEFB88A4EA" modified="2014-10-29" version="1">MRFTAEQVEQLAKDFEGKTAQQVLEWALEEFGPKIGLASSFGAEDVAIIDMMAQINKDKTHVFTLETGRLNQETYDVMDDIRARYGISITAYFPDQKEVEEMIRARGMNLMYASVENRKLCCEIRKVHPLNRALASLDGWITGLRRDQVATRASTRKIEIDSAHGGIIKLNPIADWTSEMVWDYIKKNNVPYNKLHDMGYPSIGCEPCTRAVEPGEDPRAGRWWWENAAHKECGLHFDPVKMMKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MU97</accession>
    <name>A0A075MU97_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphoserine phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">O-phosphoserine phosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NTE_02233</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SR1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HAD-like hydrolase superfamily. SerB family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.3" evidence="4"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148702120.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MU97"/>
    <dbReference type="STRING" id="1459636.NTE_02233"/>
    <dbReference type="GeneID" id="41597953"/>
    <dbReference type="KEGG" id="nev:NTE_02233"/>
    <dbReference type="eggNOG" id="arCOG01158">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036368_4_3_2"/>
    <dbReference type="OrthoDB" id="10041at2157"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00198"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036424">
        <property type="term" value="F:L-phosphoserine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050582">
        <property type="entry name" value="HAD-like_SerB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004469">
        <property type="entry name" value="PSP"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01488">
        <property type="entry name" value="HAD-SF-IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00338">
        <property type="entry name" value="serB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43344">
        <property type="entry name" value="PHOSPHOSERINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43344:SF2">
        <property type="entry name" value="PHOSPHOSERINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0718">Serine biosynthesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIF84287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="218" mass="24194" checksum="4FEFAAE094DFC397" modified="2014-10-29" version="1">MLAVFDVEGVLLDAEYLPVLASIMGPEKEKEIWDITKAGIRGEINWEEGLVRRVHALRGIDHDKAKEIAENLPIMPGAKELCSALKNAGWRMIAVSGGFTIITDRLKHDLGIDKIFSNELIFKNNKLEDVKLNVTSDKAAAIKSTVQEWGVRRDDIVVVVDGANDLKLFALAGYTVGFCPVEIVKERADDTIERRDLSLLLHLLEKKYGKAVLATTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUG4</accession>
    <name>A0A075MUG4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">A-type ATP synthase subunit D</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">atpD</name>
        <name evidence="5" type="ORF">NTE_03277</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the A-type ATP synthase that produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Has multiple subunits with at least A(3), B(3), C, D, E, F, H, I and proteolipid K(x).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the V-ATPase D subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701734.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUG4"/>
    <dbReference type="STRING" id="1459636.NTE_03277"/>
    <dbReference type="GeneID" id="41598931"/>
    <dbReference type="KEGG" id="nev:NTE_03277"/>
    <dbReference type="eggNOG" id="arCOG04101">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069688_2_0_2"/>
    <dbReference type="OrthoDB" id="117390at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00271">
        <property type="entry name" value="ATP_synth_D_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002699">
        <property type="entry name" value="V_ATPase_D"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00309">
        <property type="entry name" value="V_ATPase_subD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11671">
        <property type="entry name" value="V-TYPE ATP SYNTHASE SUBUNIT D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01813">
        <property type="entry name" value="ATP-synt_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF85306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="220" mass="25134" checksum="C1FE92C206D7C75B" modified="2014-10-29" version="1">MSSRRVTATKIELIKIRRSMQVAKMVHKILDDKREVLLKKIDEMIEEANKAREDIWSPLGEIYSAVYNAYMTLGTTTLESISDSTPSVMETDVNVRRIVDVKIPTLTVKTREGSQHLSYGFIETNASVDKASKLIKNMLPSVCKAAEYENAIFSLAKELERTQKLINALEYIIIPQYQDAIYFIKATLEEREREEFVRIKKVKVVLDRKKLAEAEATTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUH7</accession>
    <name>A0A075MUH7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Periplasmic component of the Tol biopolymer transport system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_02825</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TolB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_420835311.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUH7"/>
    <dbReference type="STRING" id="1459636.NTE_02825"/>
    <dbReference type="GeneID" id="41598510"/>
    <dbReference type="KEGG" id="nev:NTE_02825"/>
    <dbReference type="eggNOG" id="arCOG03383">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065333_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="WD40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36842:SF1">
        <property type="entry name" value="PROTEIN TOLB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36842">
        <property type="entry name" value="PROTEIN TOLB HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69304">
        <property type="entry name" value="Tricorn protease N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF84865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="342" mass="37385" checksum="A541993A9E0C15D3" modified="2014-10-29" version="1">MGYNATNNKKSAIAAVSLSMLLVASIVVSTLGTLMIITMSSSAPQKASAAFPGKNGKIVFMSTRADGTQGISVIDADGTNERRLTNNTLDYSPRWSPDGKKIAFVSWRDGTGEIYVMNADGTNQTRLTNDYADNLSPNWSSDGKKIFFTKATHLSEGFLLGDLPLVTGIYVMNADGINQTRLTNSSAIVYWPKLSPDATKIVGTAKKDGDVLYELYVTDIYGSHPTRLTTNSLHNYSPNWSPDGKKIVFISTRDGAQARVCVTDIDGTHQKRLTAVNNNFSKTDNDVDPSWSPDGKKIVYSNNKDDGNRFQIYIMDADGTHQKRLTRNGNDDVQADFGPVEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUJ1</accession>
    <name>A0A075MUJ1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03302</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_264357920.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUJ1"/>
    <dbReference type="GeneID" id="75933637"/>
    <dbReference type="KEGG" id="nev:NTE_03302"/>
    <dbReference type="HOGENOM" id="CLU_3263943_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="41" mass="4904" checksum="DC8242C29EB9246D" modified="2014-10-29" version="1">MRTCESCGRVRFYSLNFLFSKTVCNECYLKMKERNADDSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUJ3</accession>
    <name>A0A075MUJ3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acetyltransferase (Isoleucine patch superfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_02309</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700946.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUJ3"/>
    <dbReference type="STRING" id="1459636.NTE_02309"/>
    <dbReference type="GeneID" id="41598024"/>
    <dbReference type="KEGG" id="nev:NTE_02309"/>
    <dbReference type="eggNOG" id="arCOG01848">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051638_9_0_2"/>
    <dbReference type="OrthoDB" id="30669at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009085">
        <property type="term" value="P:lysine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03358">
        <property type="entry name" value="LbH_WxcM_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050179">
        <property type="entry name" value="Trans_hexapeptide_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43300:SF10">
        <property type="entry name" value="2,3,4,5-TETRAHYDROPYRIDINE-2,6-DICARBOXYLATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43300">
        <property type="entry name" value="ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14602">
        <property type="entry name" value="Hexapep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="4" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF84362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="177" mass="19051" checksum="23A9B9430E333515" modified="2014-10-29" version="1">MAKAKKKIYRNVAGVRNQVDKSAKIGKNTRIWHFAYVGAKTVVGDNVKIGSLAHVDYGVKIGNNVKIEGMVYIPPLTVIGNDVFIGPGATFTNDPYPMSPKMIGVIVEDGAIIGARSVVRPGVRIGKNSVVAMGSVVTRDVPAETVVMGVPARIAYTRQDYDHKKKEWEEGSPSPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUJ7</accession>
    <name>A0A075MUJ7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00908</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUJ7"/>
    <dbReference type="KEGG" id="nev:NTE_00908"/>
    <dbReference type="eggNOG" id="arCOG11327">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123701_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="188" mass="20336" checksum="63F1A50FFA9EE093" modified="2014-10-29" version="1">MCTTQNVVDGSFDPSYAVHDSVLSLLIGVLCENHVVSQIPPLRISDGKLVLIALVGTIAAFGILLVLVSGGAVRHVAIFLPEKTEDTIAFRNIDGEVQVMGVKGIAGVNPTLLTRTGDYVLELTVINEDDRVHVLYIDGGIHTKVLRPGDSDVITFHSKDEATYNYYDWGSGRGPLGQIQAIKVTMYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUK3</accession>
    <name>A0A075MUK3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Arabinose efflux permease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NTE_02862</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987011.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUK3"/>
    <dbReference type="GeneID" id="41598544"/>
    <dbReference type="KEGG" id="nev:NTE_02862"/>
    <dbReference type="eggNOG" id="arCOG00144">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_28_3_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17504">
        <property type="entry name" value="MFS_MMR_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF192">
        <property type="entry name" value="TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="352"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="376"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="410"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="453"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="16"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF84900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="500" mass="52703" checksum="8C1ED29B5C3E6597" modified="2014-10-29" version="1">MGSVEKQDVNSSGWRTLIILSCLGLIVMFDETMILPAIPDFIRDFHISYSTSSWILASYIIAGAVMTPIAGKLSDIYGKKKILLIVMAVYAMGILSGRFAHSIEIMVAARVAQGVGMAMFPIAFGIIREVLPEKKLAIGQTIFSSTFSGGAVIGLVAGAAIIQNFGWQATFLAILPAAIALLLVIVKFVHVRHIPMPTMEAGGSGNLSNAQKIDIKGTLALAATIVTFLAGISLLETNSDNSVYQLAGLFAASGASLAAFIAIEKRVQMPLLDLKIMTSKLFLPPVIVIMLVFMSMFMVYQTIPVMVRSPEPLGFGGDAITSARVQLPFMIVLLAGTIMSGFLLNKVGNVRLLLIGTAISTMGFFSLLAFHSTEDIVSVGLGIIAAGLSLSITGAFNVILLSVPMQVTGIALGMAMLLNLVGMSIGPSFAGMFQQMDQGTVPGVPGTFPTEAAYNMIFLTAALVSIASVVMALSVARRKIAPAVMTGEQREADKGGFAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUU1</accession>
    <name>A0A075MUU1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">SSS sodium solute transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NTE_02895</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701421.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUU1"/>
    <dbReference type="STRING" id="1459636.NTE_02895"/>
    <dbReference type="GeneID" id="41598574"/>
    <dbReference type="KEGG" id="nev:NTE_02895"/>
    <dbReference type="eggNOG" id="arCOG01316">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG02053">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010778_1_0_2"/>
    <dbReference type="OrthoDB" id="105697at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015204">
        <property type="term" value="F:urea transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11476">
        <property type="entry name" value="SLC5sbd_DUR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00293">
        <property type="entry name" value="USP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031155">
        <property type="entry name" value="DUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154:SF4">
        <property type="entry name" value="UREA ACTIVE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="87"/>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="243"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="288"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="339"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="388"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="416"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="449"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="480"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="542"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="574"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="domain" description="UspA" evidence="9">
        <location>
            <begin position="643"/>
            <end position="776"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIF84933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="777" mass="82296" checksum="C1388F46434DD984" modified="2014-10-29" version="1">MAVVLSEGLGYFILLGVGLVMALAVILLVRVETKWLGTKKTFEWFSTAGRSVKVGLIASSVVSAWTWAATLLQSSTVAYQFGISGPFWYAAGASIQVVLFAILATALKRNAPSSHTFPEIIYARFGKGSHKVFLFFALLTNTVVTAMLVLGGAAALSSLTGINISLAAFLIPVGVIIYTFSGGLKATFLAEYMNTVFLFIVVLVFVTAVYFLNPQIGGISGMFEKLSAAAALRPVDGNATGSYLTLASTGALIFGVINITGNFGTVFVDQAYWQRAIAAGPRSAFRGFLVGGLAWFAIPFTLATTLGLAAVAVNVQLSPEEISMGLVAPTAASHVLGELGAILILTILFTAVTSAGSAELVAASSLVTYDVYRTYLKPSASGRELMRISRYSIVAFGIGMGVLALALLQIGVSLQYVYLAMGVLIGSAVIPVTLVLWKKTNRVAATAGALAGLVCGVSVWIGTAYVLYGEISVQSTGHNIPLLAGNLSSISIGAAVALIGSTVRPGNFDLSLMKQKILVVDGKIKGLFEGENEEYLKKSLKFGYKVAIALTIVLVVAWPMPLYLSGYVFSETTYAVWVGIAVAWAATAAAVIIFLPLIEARVGITKALRIMGQKTNAIATQDIVAERSHKSANAAADETYYSKRILVPIDGSGQSLRALNYATNIYGINEAKIYLLYVIEWSEEEEGGDESVDEELTSKMEKEGRILLNSVIVPRRAGEYVRIVKMGDPASKIIEVAEKIGASMIVMGINGINSATEMGSVTRKVLKASSTPVVLMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUX6</accession>
    <name>A0A075MUX6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701490.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUX6"/>
    <dbReference type="STRING" id="1459636.NTE_02985"/>
    <dbReference type="GeneID" id="41598655"/>
    <dbReference type="KEGG" id="nev:NTE_02985"/>
    <dbReference type="HOGENOM" id="CLU_1567061_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="170" mass="20202" checksum="D36276EAF0F6FAD5" modified="2014-10-29" version="1">MANMLDDPFAAIAEDVDIQKFIKITKKKESKVRTKLRRSLFEQKGIKARKYTLNSDSAWKRFSDSCFAPRRTDHNRGRTYTLNEWIEKQGWIVENEKGKHFTSLKDKEILFITAWDIEKDVRIIIDGFHRACAIKYLNHSPETLEEPFEVLECYGNNMEEVSREHRLFDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUX8</accession>
    <name>A0A075MUX8_9ARCH</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUX8"/>
    <dbReference type="STRING" id="1459636.NTE_01025"/>
    <dbReference type="GeneID" id="41596848"/>
    <dbReference type="KEGG" id="nev:NTE_01025"/>
    <dbReference type="eggNOG" id="arCOG08775">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2021399_0_0_2"/>
    <dbReference type="OrthoDB" id="8555at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="120" mass="13330" checksum="9A34CD6FD92148D5" modified="2014-10-29" version="1">MIMLILVKRRTGYVLQYHKAAHLGKQRAQKAQMKLFDYTGFAMLTYTIKQSGEGSFEPVGEEELAAKMTKGEEAMLFICDRDGYAKAQSKPMPLAQGEEAFKKMVADGIPAFSGEIKTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUY2</accession>
    <name>A0A075MUY2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methylase involved in ubiquinone/menaquinone biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02937</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701454.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUY2"/>
    <dbReference type="STRING" id="1459636.NTE_02937"/>
    <dbReference type="GeneID" id="41598615"/>
    <dbReference type="KEGG" id="nev:NTE_02937"/>
    <dbReference type="HOGENOM" id="CLU_049344_5_1_2"/>
    <dbReference type="OrthoDB" id="147504at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45180">
        <property type="entry name" value="OS01G0307686 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45180:SF1">
        <property type="entry name" value="OS01G0307686 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="1">
        <location>
            <begin position="42"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="248" mass="28583" checksum="AEA6CF618CAEB5AC" modified="2014-10-29" version="1">MVDFKDLFSRQSKEYAASRPTYPKALFEFLAGLVEHRELAWDCATGNGQAAAFLAGYFDSVVASDASKKQIENARAGPNVRFAVFPAEKPDLADASVDLITVAVALHWFRFDDFYREVRRVAKKGTVIAAWAYGLHSVSPEVDRITQTFYRDVLGRYWPAEVRYVENRYKDIPFPFPQIKAPNFQIELEWDIHNLIGYLYSWSGTQKYIEENKSDPLEMIYPELEAAWGKEHAKRKVVWPIYLKVGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUZ1</accession>
    <name>A0A075MUZ1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Universal stress protein UspA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_03005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701510.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUZ1"/>
    <dbReference type="STRING" id="1459636.NTE_03005"/>
    <dbReference type="GeneID" id="41598675"/>
    <dbReference type="KEGG" id="nev:NTE_03005"/>
    <dbReference type="eggNOG" id="arCOG02053">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049301_11_1_2"/>
    <dbReference type="OrthoDB" id="105697at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00293">
        <property type="entry name" value="USP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46268">
        <property type="entry name" value="STRESS RESPONSE PROTEIN NHAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46268:SF6">
        <property type="entry name" value="UNIVERSAL STRESS PROTEIN UP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UspA" evidence="2">
        <location>
            <begin position="7"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF85040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="153" mass="16302" checksum="073992ADFA897F6A" modified="2014-10-29" version="1">MSASPVRTILVPIDGSENAYRAASFAVDLARRYGAELVVVYALDINQSLVPLGVYGAAYPQNVDKILEAASKEADPWFDRIKKETDAANVKMTGKVIEAPLSLVGEIVNYAEKINAGLIVMGSRGRTGFKKLLMGSVASGVVTYAPCPVLVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MV42</accession>
    <name>A0A075MV42_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sce7726 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02993</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701498.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MV42"/>
    <dbReference type="GeneID" id="41598663"/>
    <dbReference type="KEGG" id="nev:NTE_02993"/>
    <dbReference type="HOGENOM" id="CLU_1381349_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="197" mass="22856" checksum="59E06578DA7BC345" modified="2014-10-29" version="1">MIRGIHEVPLISVVEDYFRIQGFTTYPHATLNIAWSNIVSDVDVLAIKEDQVIAIEVKSKKDVFEKAFTQLKDIAPFVDRTFIATDDEVKANKYRNSAEEFGILYLDLVYDETIVKKKPRAMTTKPSIKQICYLRRCCLEELARGYGIPPHQSKQYIALDLLRLKYTEKLRTQLKQIVALNRQRHLHSSNRIMQLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MV47</accession>
    <name>A0A075MV47_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methylenetetrahydrofolate reductase (NAD(P)H)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02998</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701503.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MV47"/>
    <dbReference type="STRING" id="1459636.NTE_02998"/>
    <dbReference type="GeneID" id="41598668"/>
    <dbReference type="KEGG" id="nev:NTE_02998"/>
    <dbReference type="eggNOG" id="arCOG00475">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1113833_0_0_2"/>
    <dbReference type="OrthoDB" id="10385at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="253" mass="27395" checksum="A30E474FE8CF7F40" modified="2014-10-29" version="1">MKIAYELNPPKVAREGRFDQQRLDSDMDALRERASQLGRHHVDGIHLTDSVLGVPRVSSITAASFVKKSAKDAKLGCSIRTSDRNIITLCQAAADAVISGVDSLLILLGDAPTDGRNSGLKPSQAVRMLREQGFDRKLKLDLSFPAKIIDKKAPAIQAKLDARPHALVTQSISSLSDLGEIVDFVKPHGIKVVACIMVPSKKNEQSARMIGLDWSGYKKEPAEFVKKAGRMAGTVLLTSPNSFQSGIDLLKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVA2</accession>
    <name>A0A075MVA2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7 8">6,7-dimethyl-8-ribityllumazine synthase</fullName>
            <shortName evidence="7">DMRL synthase</shortName>
            <shortName evidence="7">LS</shortName>
            <shortName evidence="7">Lumazine synthase</shortName>
            <ecNumber evidence="3 7 8">2.5.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ribH</name>
        <name evidence="9" type="ORF">NTE_03548</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>(2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:26152"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58201"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="2.5.1.78"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DMRL synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.78" evidence="3 7 8"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987072.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVA2"/>
    <dbReference type="STRING" id="1459636.NTE_03548"/>
    <dbReference type="GeneID" id="41599166"/>
    <dbReference type="KEGG" id="nev:NTE_03548"/>
    <dbReference type="eggNOG" id="arCOG01323">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089358_3_1_2"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00404"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009349">
        <property type="term" value="C:riboflavin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000906">
        <property type="term" value="F:6,7-dimethyl-8-ribityllumazine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09211">
        <property type="entry name" value="Lumazine_synthase_archaeal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.960:FF:000003">
        <property type="entry name" value="6,7-dimethyl-8-ribityllumazine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.960">
        <property type="entry name" value="Lumazine/riboflavin synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00178">
        <property type="entry name" value="Lumazine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034964">
        <property type="entry name" value="LS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002180">
        <property type="entry name" value="LS/RS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036467">
        <property type="entry name" value="LS/RS_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00114">
        <property type="entry name" value="lumazine-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058:SF0">
        <property type="entry name" value="6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058">
        <property type="entry name" value="6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE DMRL SYNTHASE LUMAZINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00885">
        <property type="entry name" value="DMRL_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52121">
        <property type="entry name" value="Lumazine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="5 7 9" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>5-amino-6-(D-ribitylamino)uracil</name>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="42"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>5-amino-6-(D-ribitylamino)uracil</name>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="66"/>
            <end position="68"/>
        </location>
        <ligand>
            <name>5-amino-6-(D-ribitylamino)uracil</name>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="71"/>
            <end position="72"/>
        </location>
        <ligand>
            <name>(2S)-2-hydroxy-3-oxobutyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>5-amino-6-(D-ribitylamino)uracil</name>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>(2S)-2-hydroxy-3-oxobutyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="NCBIfam" id="TIGR00114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF85576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="154" mass="16647" checksum="3E69C77F26FEC60C" modified="2014-10-29" version="1">MQLAIVVSEFNSKITLHMLEKAKEQAKRLGAQVSFVVYVPGAFDMPLAVEKLLKKRGVDAVVTLGAVIKGDTRHDDIVAENASRLIADLSLKYAKPVALGITGPGMTAEQARERQDIVPARAVNAAVNMALRLAKLEKTVGRKTVVIDDSAYNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVB3</accession>
    <name>A0A075MVB3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Exo-alpha-sialidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03069</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701561.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVB3"/>
    <dbReference type="GeneID" id="41598733"/>
    <dbReference type="KEGG" id="nev:NTE_03069"/>
    <dbReference type="eggNOG" id="ENOG502N5KX">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_651530_0_0_2"/>
    <dbReference type="OrthoDB" id="14285at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.70">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89372">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="Sialidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="421" mass="45356" checksum="1DAD5E64410B41F5" modified="2014-10-29" version="1">MSKTKLIAAALVCVLVVGILAIAGFTNLVNSDIKSKVYASEASHRVHTVARDNLTISPSAYDNSEGGRRLIPVDNHTFVAFYYDGSNILYKVSVNKGQTWGVPQSANTGIAGSDFARWTVAATPLHGETHIVLLYSNAVSNNTMTELHAKEGVFSPISRSIKWEDKPSTLGTVSNPSSCVGNIGGGACTAAVASTDTRGNIFAAFRWSANGTGFQYAIFESTDGGISWTTSMNATWAVAPGTRGEMSLARLSLGSMLFVYAPFDANELYYSVYHAGYWSPMNMTTGSGLHFGTVKQISSISDNRHFIYVFYVKDGNSGDLMVAKWNNMGVFKGVETVDSNLSHSLPAASLGPDGVIHVFTLANDKVYEITNTGSNWTSPLIPFGTNFRNPDELTSAEAIPAAIWREDVNPLNDLFAIRFGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVI5</accession>
    <name>A0A075MVI5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701675.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVI5"/>
    <dbReference type="STRING" id="1459636.NTE_03211"/>
    <dbReference type="GeneID" id="41598868"/>
    <dbReference type="KEGG" id="nev:NTE_03211"/>
    <dbReference type="eggNOG" id="arCOG08827">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1745473_0_0_2"/>
    <dbReference type="OrthoDB" id="12077at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="149" mass="15505" checksum="914D976B2BEBDE96" modified="2014-10-29" version="1">MAAKTFIAMLGAGAAFIVIGIAASIYANTAVAVSLDGTVKPGLADELSPDMNVGNTALMQVKGSTFDIQVKDPDGSIVTSQKDLSNFTYELTASKAGEYRIAIQNTGNQDVQITGTAQTKSSPLEFSGSLMLVVTGIIVIGLSLRFRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVW1</accession>
    <name>A0A075MVW1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_01376</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVW1"/>
    <dbReference type="STRING" id="1459636.NTE_01376"/>
    <dbReference type="KEGG" id="nev:NTE_01376"/>
    <dbReference type="eggNOG" id="arCOG08812">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_600797_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF83444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="455" mass="49551" checksum="4DEB684197D0A385" modified="2014-10-29" version="1">MQRDFSFTRQSTYKHRNNNHDFYYLKNAVTYSGLIRSIVFLVTTGNIVIMLILSSPPAFAGSVTQENLPPDYARWRETNPTLAMNVTHFASQNYTMISLRLYDNRTNQNIPFSTFLLDLTDAREGTAINSSRGTFSPPASLLKDFFQAEKGELTLKIIYDPVLSGPQIAGNREPFLNAWKADPGGYIIVRTPSISPTGSYILHVTIFGAFAPSAIFSDEDTPTAILSFNGDDVRNKTVVVTNHGLNAAPAPPATDKSSKTANDSQKQGETSVIAVTKGAIIPSSNISLSKGQTTVQVPLILTYKPSVNGSSNNSGLIPFVTVEGVGACDSGNFIPASIANKMTSEQRVAILMEKSAQIDAGNLTPPTNMDHGTFLRCQFLEAQGIRIDASFAPEKVTLKPGQSATLLLSISLPKDWPSDYVNREVPVSVMLSDADNPRRTDLYIDRITVYLNPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MW14</accession>
    <name>A0A075MW14_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03417</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701855.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MW14"/>
    <dbReference type="GeneID" id="41599060"/>
    <dbReference type="KEGG" id="nev:NTE_03417"/>
    <dbReference type="HOGENOM" id="CLU_1615235_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="164" mass="19050" checksum="F057800580DAAC10" modified="2014-10-29" version="1">MAHAWKKRGVGRTVASFFYHPSKSDRIKYTPCTDVRLGGIFEHKDVYLVDMHGDGNIHGHIDLIKAYRIKHVVMADSQYRKNEYKMTKDVMTLPGKLENELARFGWFRAVKPSASPEKVYEFVMKKMKEKATGEKIRTSNLGKVFEVVLEKVGEEPERVWNQFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MW32</accession>
    <name>A0A075MW32_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700264.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MW32"/>
    <dbReference type="STRING" id="1459636.NTE_01440"/>
    <dbReference type="GeneID" id="41597235"/>
    <dbReference type="KEGG" id="nev:NTE_01440"/>
    <dbReference type="HOGENOM" id="CLU_181972_0_0_2"/>
    <dbReference type="OrthoDB" id="376940at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.200">
        <property type="entry name" value="Protein of unknown function DUF3227"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044908">
        <property type="entry name" value="NitrOD5-like_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="98" mass="11175" checksum="0E29A9A0040D5617" modified="2014-10-29" version="1">MSAYDDRNQVVSRIQEKLREFLFTETEVFYYHLENVGVRRDEILDKPEEFVDALHDIFGNGAALIESAIISEIKASNSDTAAKQGLVDVLKSIERRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWG0</accession>
    <name>A0A075MWG0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Deacetylase, histone deacetylase/acetoin utilization protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03552</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701950.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWG0"/>
    <dbReference type="STRING" id="1459636.NTE_03552"/>
    <dbReference type="GeneID" id="41599169"/>
    <dbReference type="KEGG" id="nev:NTE_03552"/>
    <dbReference type="eggNOG" id="arCOG00324">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007727_8_0_2"/>
    <dbReference type="OrthoDB" id="147549at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004407">
        <property type="term" value="F:histone deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF10">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="1">
        <location>
            <begin position="21"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="319" mass="34857" checksum="F830EA5BFCE0BA29" modified="2014-10-29" version="1">MCNTAVFFGDELARYGFGGSHPWGADRIYAFWSKLQNEKDVANVVIVEQPEITTEEAVLSFHERDYVEMVKMASKQCRSIPLDRGDTPSFRGIFEATLYVVGSTLAALDTVVQGRDRAGRKIEHAFVPVAGLHHARRDSAGGFCVFNDVGVAIIQARKKYGIKRIAYVDIDAHHGDGVFYEFEDDQLLFFADIHEYGIYPGTGYASETGKGDAKGTKMNIPLEAGSGDSEFFAAFDRVKEFVDSCRPELVFLNCGADSLAGDPITNLRYSARAHSHAAQVLHDLAHKHCNGRIIAVGGGGYNRANIGAAWTEVVKALAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWG2</accession>
    <name>A0A075MWG2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02957</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385575.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWG2"/>
    <dbReference type="STRING" id="1459636.NTE_02957"/>
    <dbReference type="GeneID" id="43502667"/>
    <dbReference type="KEGG" id="nev:NTE_02957"/>
    <dbReference type="HOGENOM" id="CLU_210682_0_0_2"/>
    <dbReference type="OrthoDB" id="375663at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="46" mass="5319" checksum="47C0FFF73D8459A9" modified="2014-10-29" version="1">MTRETLYERLGSFGVDTAFIKKLNFTDDELAAFVDKLAEVMKNHRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWQ9</accession>
    <name>A0A075MWQ9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative Ser/Thr protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03047</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701546.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWQ9"/>
    <dbReference type="STRING" id="1459636.NTE_03047"/>
    <dbReference type="GeneID" id="41598715"/>
    <dbReference type="KEGG" id="nev:NTE_03047"/>
    <dbReference type="eggNOG" id="arCOG01182">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095575_0_0_2"/>
    <dbReference type="OrthoDB" id="86092at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052396">
        <property type="entry name" value="Meiotic_Drive_Suppr_Kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37171">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE YRZF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37171:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE YRZF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="260" mass="27819" checksum="FD8CF4D28F4389B0" modified="2014-10-29" version="1">MSRQRISFSSSSELVLGSPELAKILTYPRGSDEEYASRLAELKGLGVTAVFAGGRTVIGGTSIAGKGCVGLVVRAKAHGRTCALKIRRTDANRPTMHDEVKYHRIANGAGVGPELVGYSDNFMLMEFAEGTTIAEWAQGKKLIDIKQASAVARSALEQCYALDRAGLDHGELSHVDRHIIVDNDTKATTIIIDFESASTERKPSNVSAAGQSLLVSGAVASTLAQVLRVDREAAIGALKKYKRDQTRENFDAILALVAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWR8</accession>
    <name>A0A075MWR8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWR8"/>
    <dbReference type="KEGG" id="nev:NTE_03530"/>
    <dbReference type="eggNOG" id="arCOG07262">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_209485_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="58" mass="6802" checksum="C2B714DD44C2F45F" modified="2014-10-29" version="1">MGSNLRSEASVIPLEIDDHYKRYRKEPWEVKYDQFGYCDLCNSRIDEFGYCACRGSAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWR9</accession>
    <name>A0A075MWR9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dephospho-CoA kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03057</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987033.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWR9"/>
    <dbReference type="STRING" id="1459636.NTE_03057"/>
    <dbReference type="GeneID" id="41598725"/>
    <dbReference type="KEGG" id="nev:NTE_03057"/>
    <dbReference type="eggNOG" id="arCOG01045">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096329_1_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41930:SF1">
        <property type="entry name" value="DEPHOSPHO-COA KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41930">
        <property type="entry name" value="UPF0200 PROTEIN MJ1399"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13207">
        <property type="entry name" value="AAA_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="194" mass="21305" checksum="0C694E9C649D6452" modified="2014-10-29" version="1">MPDKKKRLIVCLTGMPGAGKSTVASYLKEKGFSVITMGDAVREEAKRQKLEPTDANLGSMMLKLRKELGQGAVAHLILKKLERDGNKNNLVIDGIRSIPEVEVLKKVGEVRLLAIHASQDTRFKHLTERGRSDAPTNQDEFAGRDKRELSVGISEAIALADETLSNNEITIDQLKEKAYAIVKGWLAEAAAEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWW7</accession>
    <name>A0A075MWW7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01708</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385259.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWW7"/>
    <dbReference type="STRING" id="1459636.NTE_01708"/>
    <dbReference type="GeneID" id="43502619"/>
    <dbReference type="KEGG" id="nev:NTE_01708"/>
    <dbReference type="HOGENOM" id="CLU_3163256_0_0_2"/>
    <dbReference type="OrthoDB" id="372372at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="47" mass="5064" checksum="479BEA865569387E" modified="2014-10-29" version="1">MKQQIGGMVCTFCNAKIDYGKSVCDACAKKFNIGKYDMSKDGCGCDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MX19</accession>
    <name>A0A075MX19_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF937 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01768</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700531.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MX19"/>
    <dbReference type="STRING" id="1459636.NTE_01768"/>
    <dbReference type="GeneID" id="41597538"/>
    <dbReference type="KEGG" id="nev:NTE_01768"/>
    <dbReference type="HOGENOM" id="CLU_1792193_0_0_2"/>
    <dbReference type="OrthoDB" id="378547at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="145" mass="14650" checksum="BF140308FC46E13E" modified="2014-10-29" version="1">MNIEELSSMLSNKTGMQQSIAGTVISAVLSYAVQHFMQKGASGFMGLGGSDAGSSLQSMLSQLTSGINDPGNPLVQQVKKDGGLNDDNQARQYTQQTVDVLKESANKDSAGLSSLIGSFLGANKQGGGGGVGDIIGGLLGGAGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MX43</accession>
    <name>A0A075MX43_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01793</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MX43"/>
    <dbReference type="KEGG" id="nev:NTE_01793"/>
    <dbReference type="HOGENOM" id="CLU_1718127_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="152" mass="17517" checksum="7C7FC4B8E7908266" modified="2014-10-29" version="1">MDYGHSICDSPDCQHPHFFHGVYGCLGRNKNNLKAFCDCRRDLNNERGTAFHGKLRAILEEYFGLIETEDWFRPEAPIEIEPLPRHEVDTKYSNLPPEIRNKLYYPEDYAFEIPGEGVDTKNVQSQESPKIATSSNLKPLPPHFVRAIDLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MXN9</accession>
    <name>A0A075MXN9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_02007</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700713.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MXN9"/>
    <dbReference type="STRING" id="1459636.NTE_02007"/>
    <dbReference type="GeneID" id="41597754"/>
    <dbReference type="KEGG" id="nev:NTE_02007"/>
    <dbReference type="eggNOG" id="arCOG01586">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_951887_0_0_2"/>
    <dbReference type="OrthoDB" id="6995at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043200">
        <property type="term" value="P:response to amino acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30154:SF53">
        <property type="entry name" value="HTH-TYPE TRANSCRIPTIONAL REGULATOR LRPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30154">
        <property type="entry name" value="LEUCINE-RESPONSIVE REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13412">
        <property type="entry name" value="HTH_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF84064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="292" mass="32395" checksum="8D1EB500225AD96E" modified="2014-10-29" version="1">MDSKDFQLLVALDDNARQSYQSLGRQVLLSAPAVRDRLKRLKSKRVLQGFNLMINPSVFDRIGLVLFFNGDFQRKTALAALAAPDTSWVRLKLDGQMIVGLWTKDEDKSADHLANILGTKPSGRIFTPRKKCAPVSITDLSIMDALVDDPKMPFGELLKTTGLSPKTVRKHLNLLLETKTISIVPLLGALADSGELIYPLVITGTVGMSEVQRIMGETALLRDIQEPPMKYVLCRSNSLADVTAKVRALEKVSGVKSVEISLNREVMVSTDLRHSLIREKIKELEMVRVETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MXX5</accession>
    <name>A0A075MXX5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700770.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MXX5"/>
    <dbReference type="STRING" id="1459636.NTE_02083"/>
    <dbReference type="GeneID" id="41597818"/>
    <dbReference type="KEGG" id="nev:NTE_02083"/>
    <dbReference type="HOGENOM" id="CLU_113174_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="211" mass="23512" checksum="43BCF2DD0778943F" modified="2014-10-29" version="1">MSNATGNGKMFFILALLAVGFAVASSAVTMPTAAFASSGYDDDKNGDDKCDDDNGHDYKWSSYSKDDDKNNNCKCDDDEDDDKDYKWSSYGKDDDKNDDEDDNGNNSCYCNDDNNDDDDNDNGHYWSSYNNSDEDDDDKNDCTCNNDDDNGDDNGHDYYKYTSYNSKDDNGDDNCDDDDNGDDNGHDHYWSGFKDSAALSIKLPGVRLSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MYX3</accession>
    <name>A0A075MYX3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02409</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701031.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MYX3"/>
    <dbReference type="GeneID" id="41598120"/>
    <dbReference type="KEGG" id="nev:NTE_02409"/>
    <dbReference type="HOGENOM" id="CLU_2678684_0_0_2"/>
    <dbReference type="OrthoDB" id="376031at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="74" mass="8589" checksum="6F9DC83F806F4A7E" modified="2014-10-29" version="1">MNNKRQQLRYGIYSCMAAMVGAVGYAFVRLYGLNQRVGFDIIIVNVVVFTISAGIMVYLSWKERDIEQEEMFRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MZ67</accession>
    <name>A0A075MZ67_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SnoaL-like domain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02495</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226986975.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MZ67"/>
    <dbReference type="STRING" id="1459636.NTE_02495"/>
    <dbReference type="GeneID" id="41598199"/>
    <dbReference type="KEGG" id="nev:NTE_02495"/>
    <dbReference type="HOGENOM" id="CLU_152487_1_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="106" mass="12074" checksum="8140CE903E7DB176" modified="2014-10-29" version="1">MKTRAEELTNPAVQAVVAAMRDGNREAFFAAFAPSAELTDDGHPQPLEQWADREIFQAHGHLDVEREDNNGLELVGPFHSDQWDMKTMWRFRVINGRVQRLDVSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MZI9</accession>
    <name>A0A075MZI9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="9">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NTE_02621</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the FKBP-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="9"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226986986.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MZI9"/>
    <dbReference type="STRING" id="1459636.NTE_02621"/>
    <dbReference type="GeneID" id="41598315"/>
    <dbReference type="KEGG" id="nev:NTE_02621"/>
    <dbReference type="eggNOG" id="arCOG00980">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073526_1_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040825">
        <property type="entry name" value="FKBP26_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054016">
        <property type="entry name" value="FKBP26_IF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048261">
        <property type="entry name" value="SlpA/SlyD-like_ins_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47861">
        <property type="entry name" value="FKBP-TYPE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE SLYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47861:SF3">
        <property type="entry name" value="FKBP-TYPE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE SLYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18046">
        <property type="entry name" value="FKBP26_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22199">
        <property type="entry name" value="FKBP26_IF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 9" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="11">
        <location>
            <begin position="6"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="231"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIF84664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="255" mass="28257" checksum="703B46F418F3C73D" modified="2014-10-29" version="1">MPLEKGSLVLVDYTAKVKDTNEVFETTREEEAKKTDLYDPTRKYEPRLVSVGEAWVLKGLDEALAKAGVGDKMNVEVTPDKGFGERDPNKVRMIPQRKLGDKADEVRVGDVVELDDRTGIIRYIGSGRLQVDFNHRLAGKTLVYDVNVIKKLDTDNDKITALIKRRIPIEDAKIKFNLSGANLDMELPEETYLAEGLQIIKRAVANDIFKFVPAVKNIKFIESYAAPQPAATAEKKEEAKPAAAAATEAKAEAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N0W9</accession>
    <name>A0A075N0W9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC-type phosphate transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_03095</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PstS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701579.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N0W9"/>
    <dbReference type="STRING" id="1459636.NTE_03095"/>
    <dbReference type="GeneID" id="41598756"/>
    <dbReference type="KEGG" id="nev:NTE_03095"/>
    <dbReference type="eggNOG" id="arCOG00213">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_649922_0_0_2"/>
    <dbReference type="OrthoDB" id="10255at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050962">
        <property type="entry name" value="Phosphate-bind_PstS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42996">
        <property type="entry name" value="PHOSPHATE-BINDING PROTEIN PSTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42996:SF1">
        <property type="entry name" value="PHOSPHATE-BINDING PROTEIN PSTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12849">
        <property type="entry name" value="PBP_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PBP" evidence="3">
        <location>
            <begin position="77"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="39"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF85129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="446" mass="46525" checksum="EE7832D55DEB085B" modified="2014-10-29" version="1">MSRRKKRAALVVVIIIIVAAVAAAASIILAMTFFSPNNNNDGTRGGPDRNQTVSTPPGVGINETAGGGGPAQGPVEKTPISALSSPSALPFVDKWVAQYNSEKNLGNVKVTYSDRVDDARIPLLYSNVSSFLADYSADLAIASRPAAAKDNFTYAGSVFLPVSAQAVAVVYNIPALPDVPSGLRFDPSTLYAVVSGNATYWDDPRIKSLNPGTSLPHEQIVVVHEGPAASASDMLARYLASSSASNNSSAIAWPESSLVADSANSLAAMVRQTPYSIGYVDFAFAVQTRMTYASLQNSDGQYLMPSADSIGAAVRNGTIVAVNPAMVNGTGSENPSPALVPPPPTVSIGQLGNGSYPVVGFYYGVFSDPNAAAPGATANETALAGRDAAIIDFMQWIVGSEGQQILQDMQYPSIYEQNNDLKAFADRVLGVKTEGPPASVKQEAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N155</accession>
    <name>A0A075N155_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03177</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701645.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N155"/>
    <dbReference type="STRING" id="1459636.NTE_03177"/>
    <dbReference type="GeneID" id="41598835"/>
    <dbReference type="KEGG" id="nev:NTE_03177"/>
    <dbReference type="HOGENOM" id="CLU_1369566_0_0_2"/>
    <dbReference type="OrthoDB" id="11761at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="226" mass="26228" checksum="B91FCDE10FA3ED03" modified="2014-10-29" version="1">MVYHTHDSLDNNNNKRSRIIFLTENIVSDERQKVLTLVSLANEAIARYFGAVTSFDIVICYGSWEMEVQVISREGKRKAVGEDNDNIISSMQKAPPRVIINSVGLTDYYAEEIIIRHDSAGYGHYLHELIHGVISKDHTHQLREGLAWYFTLKLTEDHKYVRPSHPSWVDHLYVFPVKELARIVGDDFLRDFALGKGSLEVEFLPPQVQELFLPEELFYAKKRYFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N1B5</accession>
    <name>A0A075N1B5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nitroreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_03225</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nitroreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N1B5"/>
    <dbReference type="STRING" id="1459636.NTE_03225"/>
    <dbReference type="KEGG" id="nev:NTE_03225"/>
    <dbReference type="eggNOG" id="arCOG00288">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070764_7_1_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="entry name" value="NADH Oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43673">
        <property type="entry name" value="NAD(P)H NITROREDUCTASE YDGI-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43673:SF10">
        <property type="entry name" value="NADH DEHYDROGENASE_NAD(P)H NITROREDUCTASE XCC3605-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="FMN-dependent nitroreductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="3">
        <location>
            <begin position="2"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF85254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="162" mass="18293" checksum="478326B0745824CC" modified="2014-10-29" version="1">MIRKYQVRSIPDSIINKIIENAHRAPSAGHTQVQEFIIVRDAETKKKLKRVSVNQEQVEEAPLLIVVCANTSRSIGRYRQRGKEFYSVMDGAFASILILLTAVNEGIGAGFVGAFEDDKVSEILGLPEYVRPIGIIALGFPDEEPKKLERIAKERLIHHERW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N1E7</accession>
    <name>A0A075N1E7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N1E7"/>
    <dbReference type="STRING" id="1459636.NTE_03265"/>
    <dbReference type="KEGG" id="nev:NTE_03265"/>
    <dbReference type="eggNOG" id="arCOG10415">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_163107_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="101" mass="10746" checksum="12813546429972FB" modified="2014-10-29" version="1">MPNVALDRVYYMRIVLGIIAGTIAGFAIAPGTDQGTAVGMALGIAIAFFLISVVIGRMFAKGQPKEVQKKAGYDGIVPFIFMNILAMVIVYTALHQGSILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N1L9</accession>
    <name>A0A075N1L9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Trypsin-like serine protease with C-terminal PDZ domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_03330</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1C family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701776.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N1L9"/>
    <dbReference type="STRING" id="1459636.NTE_03330"/>
    <dbReference type="GeneID" id="41598980"/>
    <dbReference type="KEGG" id="nev:NTE_03330"/>
    <dbReference type="eggNOG" id="arCOG02833">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020120_2_2_2"/>
    <dbReference type="OrthoDB" id="350578at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22939">
        <property type="entry name" value="SERINE PROTEASE FAMILY S1C HTRA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22939:SF129">
        <property type="entry name" value="SERINE PROTEASE HTRA2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13365">
        <property type="entry name" value="Trypsin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="222"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF85359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="313" mass="32651" checksum="37A2E6F3BB749BA3" modified="2014-10-29" version="1">MIPVDENTLVNAVDKVSGSVVNIASVRMMHDQLFRVFPVEGVGSGVVIDQQGYILTNNHVIDDAERLKVTFADGKVLRGKVVGTDEVTDLAVIKVESEGPLQAATLGDSAALKAGQIVIAIGNPFGLTGGPTVTAGIVSSLKRSIQARTGVLELIQTDAAINPGNSGGPLVNTKGEVIAINTANMPYAQGIGFAVPINTAKTILKELVEKGRVSRPWIGIASVKVTPQLARHFGLPPSSGGALVAGVEPYSPADDAGLRRGDIIEQIDGSTVDDPSQVASHVKGKKPGSRIAVTVNRYGRQFQVGVEVDERPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N1M4</accession>
    <name>A0A075N1M4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Proteasome subunit beta</fullName>
            <ecNumber evidence="9">3.4.25.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">20S proteasome beta subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Proteasome core protein PsmB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">psmB</name>
        <name evidence="11" type="ORF">NTE_03335</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.25.1" evidence="9"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701780.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N1M4"/>
    <dbReference type="STRING" id="1459636.NTE_03335"/>
    <dbReference type="GeneID" id="41598984"/>
    <dbReference type="KEGG" id="nev:NTE_03335"/>
    <dbReference type="eggNOG" id="arCOG00970">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035750_7_2_2"/>
    <dbReference type="OrthoDB" id="6330at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02113_A">
        <property type="entry name" value="Proteasome_B_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019983">
        <property type="entry name" value="Pept_T1A_Psome_bsu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF0">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE SUBUNIT HSLV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0645">Protease</keyword>
    <keyword evidence="7 9 11" id="KW-0647">Proteasome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0888">Threonine protease</keyword>
    <keyword evidence="8 9" id="KW-0865">Zymogen</keyword>
    <feature type="propeptide" id="PRO_5005002450" description="Removed in mature form; by autocatalysis" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023275387" description="Proteasome subunit beta" evidence="9">
        <location>
            <begin position="2"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9 10">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIF85364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="201" mass="21292" checksum="B4D8261959C141E4" modified="2014-10-29" version="1">MTTIVGIKTKEGVVLGSDKRASKGFFIGSKITQKIAKIDDTLAVAIAGQLSDAEYLIKVAKAERKLMELRRGFPLTVKESARLIANLTYSGLRNYQPYFVELLVAGVDEEGGHVYTADMSGAIIGEDFASSGSGSPIAYGVLESLYHKEITNDEAKDVASKAVAAAMERDPGSGNGIDTMVIPNLVTVSVGSNSRNKEASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N1P1</accession>
    <name>A0A075N1P1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PEFG-CTERM sorting domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03351</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701794.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N1P1"/>
    <dbReference type="STRING" id="1459636.NTE_03351"/>
    <dbReference type="GeneID" id="41598999"/>
    <dbReference type="KEGG" id="nev:NTE_03351"/>
    <dbReference type="eggNOG" id="arCOG08768">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1850536_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="138" mass="14832" checksum="12A2ECE3E35E5266" modified="2014-10-29" version="1">MLYHLVDNLHQVQANGTIVDLNLSSNAKISNVNFNEEEKRLSFRMEGVGNETGSMTSVSVDKLLDGPYVVTLDGQELTDAIVVDDGDNGTIRLLAPNAGAHEITISGTNVVPEFPFAMLALTAGMASLIIVFGRTRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N213</accession>
    <name>A0A075N213_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative transcriptional regulator, contains C-terminal CBS domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_03461</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701886.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N213"/>
    <dbReference type="STRING" id="1459636.NTE_03461"/>
    <dbReference type="GeneID" id="41599095"/>
    <dbReference type="KEGG" id="nev:NTE_03461"/>
    <dbReference type="eggNOG" id="arCOG00600">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076812_3_0_2"/>
    <dbReference type="OrthoDB" id="43333at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051257">
        <property type="entry name" value="Diverse_CBS-Domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43080:SF2">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43080">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN CBSX3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="18"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="91"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="169"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="262"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF85489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="321" mass="35275" checksum="15D3876F4615C753" modified="2014-10-29" version="1">MIGETTKDILERTVKELMTKQVMTLEPYDNLLRAQNEMSRYRIKKIVIANSSGKIARKIPIGIMTVKDMLKFLLNDKTDRSLYEMKISEAMTVKLVTADADERVVNCARILKDNHNISSLVIVREDSGFSKETQSSASSRILSGIVTSTDLSRFYSENCVGLSSVGEYMSQPVVTISIDEKISTAAQLMVEKNISQLAVTSNDTAKSILGILSEKDISSVTLALKSKTQRSVSEYIGTIFASSKQNFKAFSEPSLVRIGDIFTPDPITIEKDADLAVAAKILTSHRVSALPVVDSLEGETKRNQPIGIISKTDVVTALSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLG8</accession>
    <name>A0A075MLG8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00214</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLG8"/>
    <dbReference type="KEGG" id="nev:NTE_00214"/>
    <dbReference type="HOGENOM" id="CLU_2662137_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="75" mass="8276" checksum="52C935CBA820853D" modified="2014-10-29" version="1">MAVVAVVHSLSEKDNGSGSGSNIEDYGDCNNENAIQATLHVERISLKRPDWRSYNIDCIAIMDVMMNKPVSSYKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLJ3</accession>
    <name>A0A075MLJ3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00054</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLJ3"/>
    <dbReference type="STRING" id="1459636.NTE_00054"/>
    <dbReference type="KEGG" id="nev:NTE_00054"/>
    <dbReference type="eggNOG" id="arCOG02942">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1559542_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="190" mass="21650" checksum="4AD7827DC0136216" modified="2014-10-29" version="1">MTENAHISPAAHIRHVRQHSSIVIDADASPSGYIAWYNHYTGGKNIIPVRPSPKNERFGVQRMELLAIYFALKENLAHIRRAFKRSSKRRIVVEVRSDSKTTVDQLRGTTQIRDSLMRRIVSVIGRLLAGMDYCTTIVFDHLERSRNIAGLMLEQKRRKEQEHRMEMRSSLYDMTGFAPPISSSAAALCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLJ5</accession>
    <name>A0A075MLJ5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative nucleic acid-binding protein, contains PIN domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_00254</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699340.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLJ5"/>
    <dbReference type="STRING" id="1459636.NTE_00254"/>
    <dbReference type="GeneID" id="41596166"/>
    <dbReference type="KEGG" id="nev:NTE_00254"/>
    <dbReference type="eggNOG" id="arCOG00727">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121774_1_0_2"/>
    <dbReference type="OrthoDB" id="269293at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd09873">
        <property type="entry name" value="PIN_Pae0151-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044153">
        <property type="entry name" value="PIN_Pae0151-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051619">
        <property type="entry name" value="TypeII_TA_RNase_PINc/VapC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35901:SF1">
        <property type="entry name" value="EXONUCLEASE VAPC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35901">
        <property type="entry name" value="RIBONUCLEASE VAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIN" evidence="2">
        <location>
            <begin position="15"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF82336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="154" mass="17402" checksum="040170C82A41BB9B" modified="2014-10-29" version="1">MERSKKIVAPIVVVVADASVIVKWFVDEENTENALALRQLYIDGKVEIAVPHLLPYEVLNALRYNPEFGEEQVKIASKALEKYQLWLYPVLGDLAALCVQNSFAYGISLYDSSYISLAEYLDATLYTADERILAKVVMMKGKGENFRHISDLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLM1</accession>
    <name>A0A075MLM1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleotidyl transferase AbiEii/AbiGii toxin family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00294</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699372.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLM1"/>
    <dbReference type="STRING" id="1459636.NTE_00294"/>
    <dbReference type="GeneID" id="41596200"/>
    <dbReference type="KEGG" id="nev:NTE_00294"/>
    <dbReference type="eggNOG" id="arCOG03839">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058982_1_0_2"/>
    <dbReference type="OrthoDB" id="359531at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.620">
        <property type="entry name" value="JHP933, nucleotidyltransferase-like core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014942">
        <property type="entry name" value="AbiEii"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08843">
        <property type="entry name" value="AbiEii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="263" mass="29897" checksum="968E1DE47FA394DD" modified="2014-10-29" version="1">MITDRELRAVARERNLPVDVVEKDYVLGWILFGIASSAASGSLAFKGGTALSKIYFPGRWRLSEDLDFTAVDESEMLVLGTGVMYEVPGIVQKASGINIEMKGDPLANPEFFRGKIKYTGPLSKNNIKIEISREPFIGKVVRKSVPHTYDYPKFAVKVYALDNLLAEKMRAIIERGKIRDYYDVWRLLKIRKFDKQELKELFLQKCKSKGVTFTGVEQMFPADIAKKLEPYLDTWLTRLSPEPLPELETILAELKISLKDLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MM59</accession>
    <name>A0A075MM59_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Baseplate J-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385000.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MM59"/>
    <dbReference type="STRING" id="1459636.NTE_00490"/>
    <dbReference type="GeneID" id="41596363"/>
    <dbReference type="KEGG" id="nev:NTE_00490"/>
    <dbReference type="HOGENOM" id="CLU_008328_0_0_2"/>
    <dbReference type="OrthoDB" id="148267at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.200">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="918" mass="100563" checksum="A467BD47300A5DDD" modified="2014-10-29" version="1">MAEALQFKCGSDARRSAIRDDANLNGVDYLEVRTVHSMAGTFPYPLVILYCFKDVPPAALGAENVVIEGGVRIRGVSAQWVHTATELADNPPGPFRHLVSNEERDKVINKIEDPARAIVIRPSSCGDFSTYELTLKDSPGKPPLGFDPVLSRVRFSFMVECKAEFDCLCKEPSNEVLEEPAIDYMAKDYASFRKLVLDRLTLIMPNWKDRNPADIGMMLAEVIAYVGDHLSYYQDAVATEGYLGTARKRISAARHARLLDYPVNDGRNARAWVCFSVNSPMQLEKGTTLLTKVEGEAAAGAGVFRSIDEEVAKGAEVFETMYKATLYPGKNEMNFYTWGETDCWLPAGAISASIDGAGLESVDVFNWNAVPGADSEKLTGYLENNFGLGWVAKAAITKNSPDTLTMLSAGDKLVIKLDSANGKAVLSVNEEGLYEFAAEKVVAGNDHVIKTSCLQVGDVLVFAQRGSQSGIQDADISRRHAVRLTRLSTAVDPLTGASVLQVSWAREDALPFSLCLASGGKPASLVYGNTVLADHGLTVTENLENRVASGKYYPRLSERPLTMAGPGFDASSREGGSAASAFSYGADQVLPAIELVDKSNDRLTWEPDRDLLSNDEFARVFAVETEVDGISYIRFGESRRKAWALAIRQGKPVQFGATYRIGNGVRGNVGAESITRVVMQNGKLAEEIVAFNPLPAAGGQDPETLASISLHAPQAFRRQERAVTEADYEEVLKRHPQVQQAAAAKRWTGSWYTMFVAIDRKGGQQVDGAFRNEILDFLEKYRLAGYDIEVQPPIYVPLDIAIEVCLKEGHFKGEVKERLVDAFSNRVLPNGSRGFFHPDNFTFGQPVYLSKVYEAALAVDGVQSVVVKSFHRWAKKPNHELEDAAIRTGHMEIIRLDNDPNFAENGIIRFEFCGSGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MM88</accession>
    <name>A0A075MM88_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MM88"/>
    <dbReference type="STRING" id="1459636.NTE_00520"/>
    <dbReference type="KEGG" id="nev:NTE_00520"/>
    <dbReference type="HOGENOM" id="CLU_184936_0_0_2"/>
    <dbReference type="OrthoDB" id="9475at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="81" mass="9174" checksum="FCADE75D42EE8DEF" modified="2014-10-29" version="1">MNIGNSEVNHILIAKTCGCTSSGRVAYSFVDTYHALCLDRKEIIVAELQACERLLKYADEPESRIIQREIDDLKFALDLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMC1</accession>
    <name>A0A075MMC1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMC1"/>
    <dbReference type="STRING" id="1459636.NTE_00545"/>
    <dbReference type="KEGG" id="nev:NTE_00545"/>
    <dbReference type="HOGENOM" id="CLU_2433696_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="90" mass="10187" checksum="FCAABE049EAE92BD" modified="2014-10-29" version="1">MSYSHITKCSWFFRAFQKPAFLPTVKGLPMSHRHVLPSGWLRATSIAYTDICRDGEDIFHSVRINAMSPAWMTCLMLKSKEASPKQIVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMD0</accession>
    <name>A0A075MMD0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00208</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMD0"/>
    <dbReference type="STRING" id="1459636.NTE_00208"/>
    <dbReference type="KEGG" id="nev:NTE_00208"/>
    <dbReference type="eggNOG" id="arCOG08684">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1782435_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="145" mass="16056" checksum="B0428AB49117BFCF" modified="2014-10-29" version="1">MEFSGLFYSLTTPLNICRALLASHKGIRFVGLASRNGELVAHLQRRGMTALLDNSELEVSVVLSLIRMATRSSLSRKLGSVLYSITAYENIQRITVPIYNTVSELDGILMISVDADVEIRGNTGKMILDKAEELISPLRHSQSLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMF0</accession>
    <name>A0A075MMF0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMF0"/>
    <dbReference type="KEGG" id="nev:NTE_00228"/>
    <dbReference type="eggNOG" id="arCOG08825">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1472029_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="217" mass="24484" checksum="21D5EE166D67D226" modified="2014-10-29" version="1">MLLVINLSCCCIDEEFVHVRQQSALFFIMKKQFQKKMLEIAARTTIASIIVFMAAAPSIFLQPHNRAYAHVLGITREVDNKYLVSFQLIPQFPSAGNRTDLHFSIKENNSGLSNVNLALQIVDKKSGAIVHQMPYKTYEISDVSIPYTFQNNSQYTAKLLMRLDDGNAEHMKKPLEADFDVNVRHTSVISAQELLVVTVPFTAGLVGGIFFLFKKVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMM9</accession>
    <name>A0A075MMM9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative O-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_00008</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987074.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMM9"/>
    <dbReference type="STRING" id="1459636.NTE_00008"/>
    <dbReference type="GeneID" id="41595962"/>
    <dbReference type="KEGG" id="nev:NTE_00008"/>
    <dbReference type="eggNOG" id="arCOG00979">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067676_4_1_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050362">
        <property type="entry name" value="Cation-dep_OMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10509:SF14">
        <property type="entry name" value="CAFFEOYL-COA O-METHYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10509">
        <property type="entry name" value="O-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF82092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="204" mass="22854" checksum="EEF8A3F6E1C024F9" modified="2014-10-29" version="1">MVKTSRNEKLWRVISKLDRQSGNEKSGRARVKSGEEMLAITADTGMFFHILLKAIKARRVLEVGTSTGFSTLWLADAVGKSGKVVTIENDPLKIARAKKNFRDAGVDKIIKVRQGSALDVLHKLKGKRFDFVLLDADKENIIKYFDLVLQLVRVGGIIAADNMLFPPPYRPTMRKYARHAQSHPQVQSVTVPIGMGEEITIKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMR3</accession>
    <name>A0A075MMR3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ParB-like partition protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_00487</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ParB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158384998.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMR3"/>
    <dbReference type="STRING" id="1459636.NTE_00487"/>
    <dbReference type="GeneID" id="41596360"/>
    <dbReference type="KEGG" id="nev:NTE_00487"/>
    <dbReference type="eggNOG" id="arCOG11113">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023853_0_1_2"/>
    <dbReference type="OrthoDB" id="11840at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16396">
        <property type="entry name" value="Noc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2830:FF:000001">
        <property type="entry name" value="Chromosome partitioning protein ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2830">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1530.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050336">
        <property type="entry name" value="Chromosome_partition/occlusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041468">
        <property type="entry name" value="HTH_ParB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004437">
        <property type="entry name" value="ParB/RepB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00180">
        <property type="entry name" value="parB_part"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33375">
        <property type="entry name" value="CHROMOSOME-PARTITIONING PROTEIN PARB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33375:SF1">
        <property type="entry name" value="CHROMOSOME-PARTITIONING PROTEIN PARB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17762">
        <property type="entry name" value="HTH_ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109709">
        <property type="entry name" value="KorB DNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="ParB/Sulfiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB-like N-terminal" evidence="3">
        <location>
            <begin position="16"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF82568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="284" mass="32106" checksum="2C013AAFF4004A78" modified="2014-10-29" version="1">MSNSLGLLSSSRGLIQDINISQVRYSATPIRVQKESIAELADSIRENGLLQPILVRPKDGYFEIVAGNRRCKACEILKWRKITCHVVELDDKAAFECSIIENIQRETLSVIEEAEAFKRYVTDFGWGGVSELAKGIGKSPSYITKKIKLLDMPSDVISSIIDSSLNSSVAEELCSVKDPTKQSELAALINKRHLSLRKTRELVNQYKDEEGGIESRDVERRRRAFDKMIVILRVALNNTGQVISDNDDDWVVREMLMHHKNVLHEQIDILIREKVKLGHHALGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMS9</accession>
    <name>A0A075MMS9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">Adenylosuccinate synthetase</fullName>
            <shortName evidence="8">AMPSase</shortName>
            <shortName evidence="8">AdSS</shortName>
            <ecNumber evidence="8 9">6.3.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">IMP--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">purA</name>
        <name evidence="10" type="ORF">NTE_00656</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="6.3.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8 9">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the adenylosuccinate synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.4" evidence="8 9"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699647.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMS9"/>
    <dbReference type="STRING" id="1459636.NTE_00656"/>
    <dbReference type="GeneID" id="41596517"/>
    <dbReference type="KEGG" id="nev:NTE_00656"/>
    <dbReference type="eggNOG" id="arCOG04387">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029848_0_0_2"/>
    <dbReference type="OrthoDB" id="372247at2157"/>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004019">
        <property type="term" value="F:adenylosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046040">
        <property type="term" value="P:IMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03108">
        <property type="entry name" value="AdSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.440.10:FF:000007">
        <property type="entry name" value="Adenylosuccinate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.440.10">
        <property type="entry name" value="Adenylosuccinate Synthetase, subunit A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.170.10">
        <property type="entry name" value="Adenylosuccinate Synthetase, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Adenylosucc_synth"/>
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    </dbReference>
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    </dbReference>
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    <dbReference type="InterPro" id="IPR042111">
        <property type="entry name" value="Adenylosuccinate_synth_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001114">
        <property type="entry name" value="Adenylosuccinate_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003295">
        <property type="entry name" value="PRK04293.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846">
        <property type="entry name" value="ADENYLOSUCCINATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846:SF0">
        <property type="entry name" value="ADENYLOSUCCINATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00709">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00788">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS01266">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 8 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 8 9" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="12"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="8">
        <location>
            <begin position="13"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="8">
        <location>
            <begin position="40"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="42"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="8">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="8">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="8">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="249"/>
            <end position="255"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="8">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
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        </ligand>
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        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
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        <location>
            <begin position="281"/>
            <end position="283"/>
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        <ligand>
            <name>GTP</name>
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        <location>
            <begin position="321"/>
            <end position="323"/>
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        <ligand>
            <name>GTP</name>
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        </ligand>
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    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
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    </evidence>
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        <source>
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        <source>
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            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="335" mass="36202" checksum="D2040A17ECCBCCC2" modified="2014-10-29" version="1">MPCLVTVGGFFGDEGKGKIIAYLAKKDNPVIAVRGGVGPNAGHTFAFEGKEYKVRMLPSAALNPATRLLIGAGVLVNPQVLLKEIEMFKADDRTYVDAQCGIIEQSHIDRDKSEDHLKGKIGTTGTGTGPANADRALRTLKLARDVPELSLFIEDVSNSVNYALENNENVLVEGTQGTYLSLLHGGYPFVTSKDVTASGICSDVGIGPKKVDDVLVVFKAYVTRVGGGPLANELSEDEAKKRGWMEFGSVTGRQRRAAPFDFELAKKSIRINSATQIAVTKLDVMFPSCAGVRQYEKMPADAKKFIEEIEGELGVKVTLIGTGPDLDDVVDRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MN60</accession>
    <name>A0A075MN60_9ARCH</name>
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        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_00145</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
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            <taxon>Nitrososphaerales</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
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    <dbReference type="STRING" id="1459636.NTE_00145"/>
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    <dbReference type="OrthoDB" id="106287at2157"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021527">
        <property type="entry name" value="DUF2795"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
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    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
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    <dbReference type="Pfam" id="PF11387">
        <property type="entry name" value="DUF2795"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="4"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF82227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="189" mass="20616" checksum="D8DD10E4E96BB3A2" modified="2014-10-29" version="1">MAQFKCEICGDGFEQKSRFERHLATAHPDRAPSAADLEKALSGVQYPKTKEELLTAYASQQVSDDELRKLVESLPSRTYRDAAEVAIALGEVKKKQGIRSASEVAESEAPSARGGRTAASTATSAAAVAKALSGVDFPKRKDELKEYAQRHILESGLDNPKDIVDMIGMLPDKEYHDMSDVEKSLFAQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MN65</accession>
    <name>A0A075MN65_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type multidrug transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_00155</name>
    </gene>
    <organism evidence="5 6">
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        <dbReference type="NCBI Taxonomy" id="1459636"/>
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            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
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    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MN65"/>
    <dbReference type="STRING" id="1459636.NTE_00155"/>
    <dbReference type="KEGG" id="nev:NTE_00155"/>
    <dbReference type="eggNOG" id="arCOG00194">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025302">
        <property type="entry name" value="DrrA1/2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43582">
        <property type="entry name" value="LINEARMYCIN RESISTANCE ATP-BINDING PROTEIN LNRL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43582:SF2">
        <property type="entry name" value="LINEARMYCIN RESISTANCE ATP-BINDING PROTEIN LNRL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13732">
        <property type="entry name" value="DrrA1-3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="25"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF82237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="367" mass="40514" checksum="B83A481A3B9B5E37" modified="2014-10-29" version="1">MIFLRNKKMQKEEEKEMQLEKKNAIEVHNLTKTYRGNIPAVDSISFSVMPGEIFGLLGPNGAGKTSTIKMIVTLAKATFGRLEVFGVDVSRSPQIARGMMGYVPQSISVDADLTAYENLLIFSKLSYVSKQDRDERIREALQYMGLAGRANDLVKHFSGGMMRRLEIAQALVNRPRILLLDEPSIGLDPASKRQVWKSIKQLRQDYGTTVLITTHDMTEADVLCDRVAIMSAGNIAALGNPAELKRTIGGGDRVTVNFLASAVRPQDMEFLSSLGKVVAIGNNNDDEEGDETSVQILVGDGEEAVPHIMDSFRNNGIQIESISVSKPTLDDVFMKYANRRLDCEEEMVAAAKSNSSGARRDFVRHAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNM5</accession>
    <name>A0A075MNM5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699395.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNM5"/>
    <dbReference type="GeneID" id="41596227"/>
    <dbReference type="KEGG" id="nev:NTE_00330"/>
    <dbReference type="HOGENOM" id="CLU_1936375_0_0_2"/>
    <dbReference type="OrthoDB" id="9620at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046657">
        <property type="entry name" value="DUF6766"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20554">
        <property type="entry name" value="DUF6766"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="131" mass="15393" checksum="E340C3DDD4027821" modified="2014-10-29" version="1">MLDILKKSKRGYIWITLGFFVVSLTVHWTFAWFAYVQEQQEHNQPIEATGYFNQTMRDTMENWQSEFLQLMWQVGGLSFLLYVGSPQSKESSERMEAKIDLLINNLKVLAENPERVKASLDEIDKKYYKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNR3</accession>
    <name>A0A075MNR3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Universal stress protein UspA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385128.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNR3"/>
    <dbReference type="STRING" id="1459636.NTE_01113"/>
    <dbReference type="GeneID" id="41596928"/>
    <dbReference type="KEGG" id="nev:NTE_01113"/>
    <dbReference type="eggNOG" id="arCOG02053">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049301_16_2_2"/>
    <dbReference type="OrthoDB" id="105697at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00293">
        <property type="entry name" value="USP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31964">
        <property type="entry name" value="ADENINE NUCLEOTIDE ALPHA HYDROLASES-LIKE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31964:SF113">
        <property type="entry name" value="USPA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UspA" evidence="1">
        <location>
            <begin position="8"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="149" mass="16279" checksum="895D5E7CB5609FB7" modified="2014-10-29" version="1">MEGPGEKIRRIIVAVDSSENSRKCAGFAASLANATGCETIVLTVIKNSDIADTEGRIDHDKLQKAEEETRRLHESLVVGSNMFTFKNKIRSEIVRADDISDAICKYCAETNADIVIVGRRGLGFLKGMLIGSVSEKVTRNCQCSVMIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNX3</accession>
    <name>A0A075MNX3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Short-chain alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_00430</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699470.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNX3"/>
    <dbReference type="STRING" id="1459636.NTE_00430"/>
    <dbReference type="GeneID" id="41596309"/>
    <dbReference type="KEGG" id="nev:NTE_00430"/>
    <dbReference type="eggNOG" id="arCOG01265">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_10_2"/>
    <dbReference type="OrthoDB" id="7442at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000047">
        <property type="entry name" value="NADP-dependent L-serine/L-allo-threonine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43115">
        <property type="entry name" value="DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43115:SF4">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000126">
        <property type="entry name" value="11-beta-HSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="4">
        <location>
            <begin position="6"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF82512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="247" mass="26415" checksum="44E9E2C843DDD202" modified="2014-10-29" version="1">MTIKGKVAIVTGASSGIGQATALALAKAGAKVAGGARRTDKLDALKAEIKKAGGEAFVQKLDVTKKPECDAFVDAVVKEWGTVDILVNNAGLMPLSFFKNMKVDEWDRMIDVNLKGVIYCTAAAIPHMMAKKSGHIVNLSSIAGRVVFPAGSVYCATKHAVTAFSEGLRQEFSQRSGIRVTCIEPGVVDTELNNSITDASLAKFVESTKQMESLKAQDIANAILFAVDSPHYVNVNEIMLRPTSQER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNX6</accession>
    <name>A0A075MNX6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01153</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="KEGG" id="nev:NTE_01153"/>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="AIF83226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="114" mass="12607" checksum="D1F37CAD65AD330C" modified="2014-10-29" version="1">MDAGRRPAGPLSSLFAGSEAAKVIDFLLSKKDQHQTISEIHAGTRASLDMINKIIGNLLDIDAVGIGARRVDGLGNEDKSKDENTYYIRDDTDTGKSIKDLWYHLMQVQTKNFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNZ6</accession>
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    <organism evidence="1 2">
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        <lineage>
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            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1459636.NTE_01173"/>
    <dbReference type="KEGG" id="nev:NTE_01173"/>
    <dbReference type="HOGENOM" id="CLU_3371266_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="34" mass="3846" checksum="96B8E90052B5B399" modified="2014-10-29" version="1">MNLSEENAKAMKNDEARCSKSAFHTYRSIKSKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNZ8</accession>
    <name>A0A075MNZ8_9ARCH</name>
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        <submittedName>
            <fullName evidence="3">TIGR00270 family protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">NTE_00450</name>
    </gene>
    <organism evidence="3 4">
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        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNZ8"/>
    <dbReference type="STRING" id="1459636.NTE_00450"/>
    <dbReference type="KEGG" id="nev:NTE_00450"/>
    <dbReference type="eggNOG" id="arCOG01863">
        <property type="taxonomic scope" value="Archaea"/>
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    <dbReference type="HOGENOM" id="CLU_130237_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004451">
        <property type="entry name" value="MJ0586"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00270">
        <property type="entry name" value="multiprotein bridging factor aMBF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="95"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF82532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="161" mass="18143" checksum="1B69BECAEF80786B" modified="2014-10-29" version="1">MAGKVNFIRMRLAGWKKHKMSYCELCGRPAAERKMVVVDGTVFKVCMSCSKHGKPYTPAQVPASKKKKTTPAPARQPKIGMADDLVLDPEFPRLIREARMKKGITHEQLGMQMNEKANLLRRFETGALKPDELFAKKLERHLGIKLYISASTAATTEEKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MP13</accession>
    <name>A0A075MP13_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
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        <lineage>
            <taxon>Archaea</taxon>
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            <taxon>Nitrososphaerales</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="342"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="454" mass="51712" checksum="FCA4746AC1408224" modified="2014-10-29" version="1">MTAQTEEDVTMGILADHINNVPRKQIAERRSTSETNVQNKVSKFAKFVGGPDRLKAHREFAKTHNQSQMHPSKAVWGYETAVAFAKVGLDNAKEFADGLMPLMGPEVNRKTFGSTLRWTAAKYTVNPYLPLDEIPKKAEEDLQTFRNIRADIDAGLAKLEDVQRQENAARDQLAKKEAFDKLLTKNDLDYSDIPEISRMFVEYEKDGCSPKKMVGKLSDVENYDARVAAAKKYLAEVEKLTEQKIKELESANVAIELQRVANRGCLLPHQIEILAEKIAQIAIQRGVSKELAFPRFLHDVEEHYSPIVGFQKWLACQEQKLEEKNDECLGVMAETEAWRDERQICQASVEELEVKRATVEREYREFFTEIVSMLAQSISKNLPLYVYLNRYVTRQDRLVPLLKAAMGEAIENRKLVPALVYALGLAADSLPERNHVRYEIQESRKRIARTIGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MP19</accession>
    <name>A0A075MP19_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00827</name>
    </gene>
    <organism evidence="1 2">
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        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">SR1</strain>
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    </reference>
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    <dbReference type="STRING" id="1459636.NTE_00827"/>
    <dbReference type="GeneID" id="41596671"/>
    <dbReference type="KEGG" id="nev:NTE_00827"/>
    <dbReference type="eggNOG" id="arCOG08712">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140803_0_0_2"/>
    <dbReference type="OrthoDB" id="9852at2157"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="153" mass="17385" checksum="C6A616AD5FC8A0F5" modified="2014-10-29" version="1">MRVRYWRLGITDLLESAYPSEKANHWDIKCMQGEYEHFGVFWYRYGTPFDKEPVHGICFYFNDVPKKTVDDLAAFLQGKFGGQLLYRQARGFLQGSKEFADGKAVGVLANELSLKFNAPVELTVEFEKATKEEVDSEAWKLPAGKALPIPGPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MP66</accession>
    <name>A0A075MP66_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00506</name>
    </gene>
    <organism evidence="1 2">
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        <lineage>
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            <taxon>Nitrososphaerota</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MP66"/>
    <dbReference type="KEGG" id="nev:NTE_00506"/>
    <dbReference type="HOGENOM" id="CLU_1870624_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="136" mass="15668" checksum="B9B5AE63CE986790" modified="2014-10-29" version="1">MFDHRPSLLLRQNNNIKRKVLFASGLFLIVLVLLSTTIQAPPNAAVAGAYYPFKIDGPNSVVGFNYWKMMWHYDDAKTEKQNLKAFQTWWCIDSKGSMLKNCNNKEAEPVVRDMKGLMLFVKEHTLQIISIKVTEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MP78</accession>
    <name>A0A075MP78_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, AsnC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00937</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AIF83013.1"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="18"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="86" mass="9517" checksum="D88DD5F2346455F1" modified="2014-10-29" version="1">MIIVRKVIVLVNTSLGTDGHVAEELRKIEGVKEVYKVRGVYDILVKIEAPDPDKVKEIISSKLRKIDDIRSTITMVVTNDGISALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPC5</accession>
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    <organism evidence="5 6">
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            <taxon>Nitrososphaerota</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
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            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF83063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="95" mass="10826" checksum="A18F7BBCDE2793B2" modified="2014-10-29" version="1">MASYKLLLIAIPVVAVLFMDFSIAFAQGQGEQAGQTGQYIYGRVEIWALFYRLMVIAFVIGAILMGVIFYVVYRFRESHPKNRNLPVRSTEGEHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPJ5</accession>
    <name>A0A075MPJ5_9ARCH</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1459636.NTE_00985"/>
    <dbReference type="GeneID" id="41596813"/>
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    <dbReference type="eggNOG" id="arCOG08823">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_182719_0_0_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="97" mass="11490" checksum="D375AA8AC107ADF6" modified="2014-10-29" version="1">MGRWKEEKTRRGRNWMTAMGILFLITAAIIALRDLFLISTAYTFGFYLDNFVNSEINNEKFVIAMTIGGGILLFWGYYRKKEDYGPPDEHEWRRSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPM2</accession>
    <name>A0A075MPM2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">uroporphyrinogen-III C-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.107</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NTE_01011</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.107" evidence="1"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148702030.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPM2"/>
    <dbReference type="STRING" id="1459636.NTE_01011"/>
    <dbReference type="GeneID" id="41596835"/>
    <dbReference type="KEGG" id="nev:NTE_01011"/>
    <dbReference type="eggNOG" id="arCOG00644">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011276_7_0_2"/>
    <dbReference type="OrthoDB" id="24444at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004851">
        <property type="term" value="F:uroporphyrin-III C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11642">
        <property type="entry name" value="SUMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.950.10:FF:000001">
        <property type="entry name" value="Siroheme synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1010.10:FF:000001">
        <property type="entry name" value="Siroheme synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="entry name" value="Cobalt-precorrin-4 Transmethylase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="entry name" value="Methyltransferase, Cobalt-precorrin-4 Transmethylase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006366">
        <property type="entry name" value="CobA/CysG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050161">
        <property type="entry name" value="Siro_Cobalamin_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003043">
        <property type="entry name" value="Uropor_MeTrfase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01469">
        <property type="entry name" value="cobA_cysG_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004790">
        <property type="entry name" value="PRK06136.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45790:SF3">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT UROPORPHYRINOGEN III METHYLTRANSFERASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45790">
        <property type="entry name" value="SIROHEME SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="Tetrapyrrole methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00840">
        <property type="entry name" value="SUMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tetrapyrrole methylase" evidence="7">
        <location>
            <begin position="8"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF83085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="266" mass="28458" checksum="3D2F4616BF584433" modified="2014-10-29" version="1">MSTTAAGKVYICGAGPGDPKLMTVRAMELLKSCDVILYDRLVGQEIIDQIPENAEKVYVGRAVGDPTTHQKRTNELMVRYAKKENKSVLRLKGGDPFIFGRGAEEAEYLLERGVQFEIIPGITSAIAGPAYAGIPLTHRRYSSAVAIATGHEGVDNKGDVSVDWKKLPKAVDTVVVLMGIGQLDEIAKDLIKGGMKKNTKIAIIENGTTARQRVVMGTLATAAKVATKSGIKPPAIVVIGRVASLHKKIAWFRKGVEGGRGKGAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPN3</accession>
    <name>A0A075MPN3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00717</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPN3"/>
    <dbReference type="STRING" id="1459636.NTE_00717"/>
    <dbReference type="KEGG" id="nev:NTE_00717"/>
    <dbReference type="HOGENOM" id="CLU_3263608_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="41" mass="5011" checksum="5B34CD1C79BF48F5" modified="2014-10-29" version="1">MCPRSSDEFLLFLIMVRMKVKQKKKIYSNKYGGTDRLYYRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPR5</accession>
    <name>A0A075MPR5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699941.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPR5"/>
    <dbReference type="GeneID" id="41596865"/>
    <dbReference type="KEGG" id="nev:NTE_01042"/>
    <dbReference type="eggNOG" id="arCOG08812">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_786669_0_0_2"/>
    <dbReference type="OrthoDB" id="11069at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="352" mass="37081" checksum="3F43A71216B0430F" modified="2014-10-29" version="1">MSHSSSKTVAGFMAVLLAVTFASSFSSVQVYAQSSGHMTSDQSHLPTANIGDRQLALDFTTTPAAPLPGDQIDMDLSLIDKNTGKNAPHVSYTVIITKDDGTQVFSEVVHGHEGKVSIRFINDASAQTYRVSANYDNLAASYVSDFGSPIKVQGQVFSTASNYKVAIEVTGIDFDNTFLPEPLKYDFVLPLTPKQTLTVNYQDTAFDVGAYSSAIAISKAELKTENKQLILSSSSGSGNATGHSGDFTIRLEIPKQMMSGPFSAALGSGAALDVKEDASSSSDKITTLVLTGRHEDVVQADAPSGSSQSTIIVTAANVVPEFPVGLAGTIAAVGFAAIILYVRTLKAGKMQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPS4</accession>
    <name>A0A075MPS4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NTE_01052</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPS4"/>
    <dbReference type="STRING" id="1459636.NTE_01052"/>
    <dbReference type="KEGG" id="nev:NTE_01052"/>
    <dbReference type="eggNOG" id="arCOG02358">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015921_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000001">
        <property type="entry name" value="Two-component sensor histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050736">
        <property type="entry name" value="Sensor_HK_Regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43711:SF1">
        <property type="entry name" value="HISTIDINE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43711">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="488"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF83125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="707" mass="79442" checksum="B73BE362D25690B3" modified="2014-10-29" version="1">MEEGIEPEKTEIIQGVENVVALAETISQIRERLDTCMDSNGVSSVATNLYEKLARLKEKGVKLRYITEVTRGNVPQCKKLLNAVELRHLQGIKGNFGIADGVDFRSSASVVGGQHPTEVIRSTARQFVKQQQYFFDMLWEKAIPAEQRIKEIEEGIEPEITEIVTGWDGIFKRNIESFSKARQAVDHCCDALVPPKIVGSPVYEAGTDFVKRGGKIRMITEITAENLPSVKELMKTQEIRHVNGFNLNFGISEAVFLAPTSVYAMSSNPQLIYSNSRDLIRQHQYLFDTLWEKAIPAEQRIKEIEEGIGPEFIETIKDPDKVLKLGYDLLKEAKSEVLVIFSSANAFLRQERAGLMRLLTKMAEGHGGVQIRIMTPIDDRIKETVEKFEEHSQQKIKVKSIEPSLQTRVTLLIVDRRYSLAVELKDDAKETSLEAMGMATYSNSKATVLSYTSIFESLWNQAELYERIKQLYEQLKAHSEMQKEFISIAAHELRTPIQPIIGLTEILNQKEGNSSEYHQLLEIINRNANRLNRLTETLLDVARIDSQSLRLNKETLDLNDTIMEAIGDMEKSMDNNNNKTTLSFLRKEKEDVFVNADRGRITQVIYNLLSNAIKFAGGGTVTVMLGKESNDDGRFAIVSVRDSGSGIDPEIVPRLFTKFASKSEKGTGLGLFISKGIVEAHGGKIWAKNNKDSRGATFAFSLPLVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPX1</accession>
    <name>A0A075MPX1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lactoylglutathione lyase-like lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148702044.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPX1"/>
    <dbReference type="STRING" id="1459636.NTE_01150"/>
    <dbReference type="GeneID" id="41596962"/>
    <dbReference type="KEGG" id="nev:NTE_01150"/>
    <dbReference type="eggNOG" id="arCOG03101">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057821_0_0_2"/>
    <dbReference type="OrthoDB" id="9710at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08347">
        <property type="entry name" value="PcpA_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052537">
        <property type="entry name" value="Extradiol_RC_dioxygenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36110">
        <property type="entry name" value="RING-CLEAVING DIOXYGENASE MHQE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36110:SF2">
        <property type="entry name" value="RING-CLEAVING DIOXYGENASE MHQE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="6"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="155"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="324" mass="36453" checksum="86BF72E5024D9A8F" modified="2014-10-29" version="1">MKDILGIHHVTAIASNPQKNIDFYSSLLGLRLVKLTVNFDDPTTYHLYYGDEIGHPGTILTFFPWQDAPKGVHGTSQVIATSFLIPENATGYWTERLKKHHVAFQGPIARFDEQVIAFHDPDGLALELVAHKSAREREDRVWKQGPVPAEQTIRGFYSVTLSEEGYERTASVLTDKLGFSLLREENGRFRYTISGEGASSIVDLLCLPYSKRGRIGIGTVHHVAWRTPTDPQQEELRKSIVKAGLNATPVIDRKYFHSVYFREPGGILFEIATEPPGFMIDEKKEELGTHLVLPTWLETERNNLERVLPPVKVGEKLVVGRLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQ76</accession>
    <name>A0A075MQ76_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein-disulfide isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_01147</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutaredoxin family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family. DsbA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700019.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQ76"/>
    <dbReference type="STRING" id="1459636.NTE_01147"/>
    <dbReference type="GeneID" id="41596958"/>
    <dbReference type="KEGG" id="nev:NTE_01147"/>
    <dbReference type="eggNOG" id="arCOG02868">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_47_7_2"/>
    <dbReference type="OrthoDB" id="15256at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13887">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13887:SF55">
        <property type="entry name" value="SLR0313 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13462">
        <property type="entry name" value="Thioredoxin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="2"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="183"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="188"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF83220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="213" mass="24458" checksum="45621BC88F1CAACF" modified="2014-10-29" version="1">MSSKIDEAEIARLNQPVNERDHAQGQESAPVILVEYGDYECPYCGQAYPIVKSVQKNFGDKLRFIFRNFPITQAHPHAQHAAEAAEAAGVQGKFWEMHDYLYERQRELDENHLRQYASAVGLDIARFDDEMAKHIHAGRVHNDFMSGIRSGVNGTPTFYINDIRHDDSWNEETLVETIKQTIADQQRRHPITKGSKKIAGRNAQTPKRTHYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQA0</accession>
    <name>A0A075MQA0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01299</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQA0"/>
    <dbReference type="STRING" id="1459636.NTE_01299"/>
    <dbReference type="KEGG" id="nev:NTE_01299"/>
    <dbReference type="eggNOG" id="arCOG08781">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2103386_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="129" mass="14551" checksum="8EE4155341A3FFA4" modified="2014-10-29" version="1">MLSQTISVKPRPEFDPDRIAFHVACVDYDRASLLVSDLLENMARMVGIEPRLETGPAELALGWTFYTLSVNKEVARRFASLPESDILQSKGATLDQKFATWLNRQLAARMQGIQVRLLSDLKSSQFGFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQE5</accession>
    <name>A0A075MQE5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pyridoxal 5'-phosphate synthase subunit PdxS</fullName>
            <shortName evidence="7">PLP synthase subunit PdxS</shortName>
            <ecNumber evidence="7">4.3.3.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Pdx1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pdxS</name>
        <name evidence="10" type="ORF">NTE_01229</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + phosphate + 3 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31507"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="4.3.3.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">In the presence of PdxT, forms a dodecamer of heterodimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the PdxS/SNZ family.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.6" evidence="7"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700091.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQE5"/>
    <dbReference type="STRING" id="1459636.NTE_01229"/>
    <dbReference type="GeneID" id="41597037"/>
    <dbReference type="KEGG" id="nev:NTE_01229"/>
    <dbReference type="eggNOG" id="arCOG04075">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055352_1_0_2"/>
    <dbReference type="OrthoDB" id="6840at2157"/>
    <dbReference type="UniPathway" id="UPA00245"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036381">
        <property type="term" value="F:pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000001">
        <property type="entry name" value="Pyridoxine biosynthesis protein PDX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01824">
        <property type="entry name" value="PdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001852">
        <property type="entry name" value="PdxS/SNZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033755">
        <property type="entry name" value="PdxS/SNZ_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003215">
        <property type="entry name" value="PRK04180.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31829">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNZ1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31829:SF0">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNZ1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01680">
        <property type="entry name" value="SOR_SNZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029271">
        <property type="entry name" value="Pdx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51129">
        <property type="entry name" value="PDXS_SNZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0704">Schiff base</keyword>
    <feature type="domain" description="PdxS/SNZ N-terminal" evidence="9">
        <location>
            <begin position="34"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with D-ribose 5-phosphate" evidence="7">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="265"/>
            <end position="266"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIF83300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="326" mass="35369" checksum="2AF4B56117B5E239" modified="2014-10-29" version="1">MTISLVASEPGAKGIKVQDAVAGESARAVRGTTLLKRGFAHMQKHGVVMDVTSVEQAQIAEEAGAVAVMVLDKLPYDVRKAGGVARTASIKVIEEIMDAVTIPIMAKCRIGHIDEAKVLEVTGVDMIDESEVLTPADEERHIWKWDFTTPFVNGGKNLGEALRRIEEGAAMIRTKGEPGTGNVAEAVTHIRMVNNEIRRIRSHYLDDDKQELMKAARELKVSFAIVEETARLGRLPVVNFAAGGITTPADAAFLMNLGCDGVFVGSGIFKSDDPAQRARAVVLATTFYDDAKIVKEAQKMVDEKKSLLGLDTKNLELRMQERGQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQL5</accession>
    <name>A0A075MQL5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alternative thymidylate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01444</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
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    <dbReference type="STRING" id="1459636.NTE_01444"/>
    <dbReference type="GeneID" id="41597239"/>
    <dbReference type="KEGG" id="nev:NTE_01444"/>
    <dbReference type="eggNOG" id="arCOG01884">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024745_0_0_2"/>
    <dbReference type="OrthoDB" id="8310at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050797">
        <property type="term" value="F:thymidylate synthase (FAD) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004799">
        <property type="term" value="F:thymidylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006231">
        <property type="term" value="P:dTMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20175">
        <property type="entry name" value="ThyX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.170">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003669">
        <property type="entry name" value="Thymidylate_synthase_ThyX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036098">
        <property type="entry name" value="Thymidylate_synthase_ThyX_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34934">
        <property type="entry name" value="FLAVIN-DEPENDENT THYMIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34934:SF1">
        <property type="entry name" value="FLAVIN-DEPENDENT THYMIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02511">
        <property type="entry name" value="Thy1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69796">
        <property type="entry name" value="Thymidylate synthase-complementing protein Thy1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51331">
        <property type="entry name" value="THYX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="552" mass="63598" checksum="1C465FA3268848CC" modified="2014-10-29" version="1">MAADDHGAFLDSFTDEEKAVLAGHFSNADRAVFAVTTPRQVDRGALMSRYSRTDKSMRRVFLDEFAKNPNRGEEFYRKVLLEYGDDSVAELGEAQVALEGISNIAAKKIEDRRIGLSYLEKSSRYVPFDKKVAGGMYRYLREGRIMSSRHADHYLAACDLAFDTYSKSLLAMTNFLEEQEPIDKFSFFDSSLQKERQFGGLREQKDIDAAQRIYRATIRAKALDLLRGLLPASTLTNVGITGNGRAFEYLLTIMHGSRLSELRSLGEQLFSELNGVIPSFVRRANDKYGQAMQAYFAKTENAVRDLAKKHLSGMNSESSPEKVRLLEPEDNFAAEVKVASAILYEQADGRPLEKVMRYVKSMPSQDRHGIIRAYTRYRENRRQRPGRAFEMVDCIFELFTNFGMFRDLHRHRVLTLERQLLSTRHGYDMPGEIKEAGLGKEFQECMSASKDAYEAIAKEMPEEAQYVVNFAYRYPYFMKMNLREACHMVELRTVPQGHPDYRQVCQEMYRQLQKAHPVLAEGIKFADMNSYQLERFDAEKRTEKKRQESERQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQN5</accession>
    <name>A0A075MQN5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type antimicrobial peptide transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_01104</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987188.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQN5"/>
    <dbReference type="STRING" id="1459636.NTE_01104"/>
    <dbReference type="GeneID" id="41596919"/>
    <dbReference type="KEGG" id="nev:NTE_01104"/>
    <dbReference type="eggNOG" id="arCOG00922">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098796">
        <property type="term" value="C:membrane protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000032">
        <property type="entry name" value="Export ABC transporter ATP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015854">
        <property type="entry name" value="ABC_transpr_LolD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24220:SF86">
        <property type="entry name" value="ABC TRANSPORTER ABCH.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24220">
        <property type="entry name" value="IMPORT ATP-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="21"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF83177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="245" mass="26405" checksum="6E05F505F4939C56" modified="2014-10-29" version="1">MDTTRESALNNAGSDSQTVVMKVDNITKVFDSAAGRVAALRGVNISIRKGEFVAIVGPSGSGKSTLLNIIGALDKPTSGKVYINGIDVFALADSEMATMRNHLIGFIFQSYNLINRTTVLKNVELPGVLSGMGSAERQRRAEKLLEVLGIGNKAGFKPVNLSGGQQQRVAIARSLMNDPAIILADEPTGNLDTKTGNEVFDLLKMLSSKFRRTIVMVTHNPELAEACDRAIYIRDGKVEKEVVNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQX7</accession>
    <name>A0A075MQX7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Replication restart DNA helicase PriA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01441</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700265.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQX7"/>
    <dbReference type="STRING" id="1459636.NTE_01441"/>
    <dbReference type="GeneID" id="41597236"/>
    <dbReference type="KEGG" id="nev:NTE_01441"/>
    <dbReference type="eggNOG" id="arCOG06883">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_848878_0_0_2"/>
    <dbReference type="OrthoDB" id="8482at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040572">
        <property type="entry name" value="TackOD1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18551">
        <property type="entry name" value="TackOD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thaumarchaeal output" evidence="1">
        <location>
            <begin position="55"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="327" mass="36589" checksum="7F6461B09E1736D1" modified="2014-10-29" version="1">MSGMELDNNNNNSRSIIDLKDDSTLAFLASYAKKHREDIPPQFRHGIGIIYEIENADLSFERIRNYEQEKLLSVTGSKSYSACPRCKSLLLSLRLSCPDCKRPSLARSEIMIHYSCEYSGPVEEFVSQKDSEYVCPKCSKQMKRVGIEYGKPGIGFKCRDCGRVFQYPLVIAVCHNGHELKVDEIDLQHFPIYRINDEIRNFAEVTEYFTSVQQALTGRGLEAQVLCKIRGGSGVTHIIPLVVRTAKAPVIVDFILDESGFDAKILQKILRGADLSKYVMLLFVPEGLVSRLAPIVNPEKIKLVPLSSGSKREDPAEVAEEVIKAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MR77</accession>
    <name>A0A075MR77_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methylase involved in ubiquinone/menaquinone biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_01637</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700422.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MR77"/>
    <dbReference type="STRING" id="1459636.NTE_01637"/>
    <dbReference type="GeneID" id="41597413"/>
    <dbReference type="KEGG" id="nev:NTE_01637"/>
    <dbReference type="eggNOG" id="arCOG01778">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063529_1_1_2"/>
    <dbReference type="OrthoDB" id="8915at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053173">
        <property type="entry name" value="SAM-binding_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048711">
        <property type="entry name" value="WHD_Rv2258c"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45128">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45128:SF1">
        <property type="entry name" value="S-ADENOSYLMETHIONINE-DEPENDENT METHYLTRANSFERASE RV2258C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21320">
        <property type="entry name" value="WHD_Rv2258c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="S-adenosylmethionine-dependent methyltransferase Rv2258c-like winged HTH" evidence="2">
        <location>
            <begin position="23"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="170"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF83698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="358" mass="39359" checksum="35EBA1E419EB13FE" modified="2014-10-29" version="1">MSKEENENNDFGGRFLQILNDGMLCLMTSVGHKTGLFDAMARLSPSTSIEIAKAAKLNERYVREWLGAMVTGRIIDYEPSTGRYSLPAAHASCLTRDAGIDNLAMFTQYIALMGNVEDDIVKCFKKGGGVPYSAFPKFQEIQAEETARVFDARLVGDILPLAQGLTGRLKSGIDVLDVGCGTGHAINLMAKAFPKSRFWGYDISREGIGAARAEAKKMKLKNAKFKIVDASKIGDREKFDLVTAFDTIHDQARPAKVLKCIHRALRKGGTFLMQDIAASSRLHENMENPLAPSLYTISTMHCMTVSLAYGGEGLGTVWGEQKAKEKLAEAGFESIDVRQVEGDILNYYYVTTKMSKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MR89</accession>
    <name>A0A075MR89_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cysteinyl-tRNA synthetase</fullName>
            <ecNumber evidence="5">6.1.1.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_01647</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.1.1.16" evidence="5"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385247.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MR89"/>
    <dbReference type="STRING" id="1459636.NTE_01647"/>
    <dbReference type="GeneID" id="41597422"/>
    <dbReference type="KEGG" id="nev:NTE_01647"/>
    <dbReference type="eggNOG" id="arCOG00486">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013528_0_1_2"/>
    <dbReference type="OrthoDB" id="9445at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006423">
        <property type="term" value="P:cysteinyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.640">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890:SF3">
        <property type="entry name" value="CYSTEINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="CYSTEINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA synthetases class I catalytic" evidence="4">
        <location>
            <begin position="22"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF83708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="371" mass="41080" checksum="0A4D95E06325F8C6" modified="2014-10-29" version="1">MKVYDTLAAKKKDFVPGSAAAAARIFLCGPTVYDYSHVGHARMLLFYDAVTRYLRFLGAETRVIVNITDIDPKIFARAKAEGMAPKELATYYISELLYDAAALGIDGFAFARVSDHVHTAQALARRLLDEGKAYIASGNVYLDAKSAGFGRLSKMTDKELADCRLDIAPGKKSPLDILLWSTNDDFGISFSDRVLGSGIPWWHMQDTSVAVASFGGAYDMHGGADELVYPHHESHLAQMSAITSEKEPVKLWTHVGLVYVKGKKMSKSLGNAVAIKRLLQDHSANAVRLYLYSTHYRERLDFAENRLAKYAELDDIISSAADKKCKPAHMKKFMQKMDDDFDTQGAMRVMLEAARAGAGTREMAEILGLRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRH2</accession>
    <name>A0A075MRH2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01623</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRH2"/>
    <dbReference type="STRING" id="1459636.NTE_01623"/>
    <dbReference type="KEGG" id="nev:NTE_01623"/>
    <dbReference type="HOGENOM" id="CLU_1673903_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="157" mass="17533" checksum="1FC145888FA57472" modified="2014-10-29" version="1">MTKYFFSPCNDELGQIGRYSLFVGVLIFLFSVYIFSLAKRNEAKQSYEPIMIMPILRHYGDDDISRSSDGTQICTFSLKNVGDGSAKNLQIKATSSSDGRQLTVDPRTPGKNEAWEVSEWNVQDLKTGEKVDIEVNYTDIKGNPCSALRFTVGAEAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRM3</accession>
    <name>A0A075MRM3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidyl-tRNA hydrolase</fullName>
            <ecNumber evidence="2">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NTE_01654</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PTH2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="2"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRM3"/>
    <dbReference type="STRING" id="1459636.NTE_01654"/>
    <dbReference type="KEGG" id="nev:NTE_01654"/>
    <dbReference type="eggNOG" id="arCOG04228">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073661_2_2_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02430">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1490.10:FF:000001">
        <property type="entry name" value="Peptidyl-tRNA hydrolase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1490.10">
        <property type="entry name" value="Bit1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023476">
        <property type="entry name" value="Pep_tRNA_hydro_II_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002833">
        <property type="entry name" value="PTH2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00283">
        <property type="entry name" value="arch_pth2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003314">
        <property type="entry name" value="PRK04322.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649:SF11">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01981">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102462">
        <property type="entry name" value="Peptidyl-tRNA hydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF83715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="117" mass="12697" checksum="F80A3AB49BF8F6AC" modified="2014-10-29" version="1">MDFKQVMVIRRDLGMGTGKIAAQVAHAAVMAAERTKQKKPDWFDSWFEGGQAKVVVKVQSFEELIDVKNHAESLKLPVVLVQDSGLTQVPPGTATCVGIGPAPADLVDKVTERLKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRP4</accession>
    <name>A0A075MRP4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01684</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385251.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRP4"/>
    <dbReference type="STRING" id="1459636.NTE_01684"/>
    <dbReference type="GeneID" id="43502617"/>
    <dbReference type="KEGG" id="nev:NTE_01684"/>
    <dbReference type="HOGENOM" id="CLU_3130976_0_0_2"/>
    <dbReference type="OrthoDB" id="372383at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="57" mass="6394" checksum="88C082C1203C44BB" modified="2014-10-29" version="1">MVASSEARLAKRFCEHCFYRGAESEFLAAADFCIECMSVHAHCPKCKSSFHSVHVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRV5</accession>
    <name>A0A075MRV5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphoribosylaminoimidazole-succinocarboxamide synthase</fullName>
            <ecNumber evidence="7">6.3.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">SAICAR synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">purC</name>
        <name evidence="9" type="ORF">NTE_01843</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate + ATP = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:22628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SAICAR synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.6" evidence="7"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700590.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRV5"/>
    <dbReference type="STRING" id="1459636.NTE_01843"/>
    <dbReference type="GeneID" id="41597607"/>
    <dbReference type="KEGG" id="nev:NTE_01843"/>
    <dbReference type="eggNOG" id="arCOG04421">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045637_0_1_2"/>
    <dbReference type="OrthoDB" id="10775at2157"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004639">
        <property type="term" value="F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01414">
        <property type="entry name" value="SAICAR_synt_Sc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00137">
        <property type="entry name" value="SAICAR_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028923">
        <property type="entry name" value="SAICAR_synt/ADE2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001636">
        <property type="entry name" value="SAICAR_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018236">
        <property type="entry name" value="SAICAR_synthetase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00081">
        <property type="entry name" value="purC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43700">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43700:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01259">
        <property type="entry name" value="SAICAR_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01057">
        <property type="entry name" value="SAICAR_SYNTHETASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01058">
        <property type="entry name" value="SAICAR_SYNTHETASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAICAR synthetase/ADE2 N-terminal" evidence="8">
        <location>
            <begin position="4"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF83903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="277" mass="31804" checksum="E3B2B0D6A9341A67" modified="2014-10-29" version="1">MRLIRKGKVKDIYQLDDGNILFHFSDRVSAFDVKMATPIPRKGEVLCRFGEFWFNTLGTPHHMLRVQDKDKMVVKKLTMIPLECVVRGYFYGSFAERFKDHLGKSLPADYKPVMAGKLPRPIFDPTTKSEEHDMPVNKEQAISMGLVSKDDYEFLEKTSISLYEKMSAIVEKAGFIIADVKFEFGRDESGRIVLGDSLGPDEYRLWLKADYQPGRIQEAYDKQLLRDWLIKTGFKAEIDRLAKEGKKPEPPAVAPEIAGELSRRYILAYERISGRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MS06</accession>
    <name>A0A075MS06_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription initiation factor IIB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NTE_02242</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TFIIB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MS06"/>
    <dbReference type="STRING" id="1459636.NTE_02242"/>
    <dbReference type="KEGG" id="nev:NTE_02242"/>
    <dbReference type="eggNOG" id="arCOG01981">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043736_0_1_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023486">
        <property type="entry name" value="TFIIB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618:SF13">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00782">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Cyclin-like" evidence="7">
        <location>
            <begin position="87"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="7">
        <location>
            <begin position="178"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF84296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="281" mass="31336" checksum="3D0CA162A6157A30" modified="2014-10-29" version="1">MSDKASETRAEWRDFGSESEKRIRTGRHTSLARHDMGLSTTIGKTNRDASGRLIDAENRHMIDRLRVWDHRIQLGAPSERGLTKAFDELNRTRVKLSLSETMVEKAAYLYRKAYERKLVRGRSISSLLGACIYLACRELDTPITLKDITAAGNIKRRDVSRSYRLLLTELDIKVPLVDPMRCVAKIANKAQLNERILRQALSLMRDVAGTGVQVGKAPMCFAATVLYIACRKSGSNITQRNIAEAAGVTEVSIRNRVREFTKGLDSIDTTTAVPSSPISDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MS45</accession>
    <name>A0A075MS45_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">META domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700935.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MS45"/>
    <dbReference type="STRING" id="1459636.NTE_02298"/>
    <dbReference type="GeneID" id="41598013"/>
    <dbReference type="KEGG" id="nev:NTE_02298"/>
    <dbReference type="HOGENOM" id="CLU_139555_0_0_2"/>
    <dbReference type="OrthoDB" id="379136at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005184">
        <property type="entry name" value="DUF306_Meta_HslJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038670">
        <property type="entry name" value="HslJ-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03724">
        <property type="entry name" value="META"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF306" evidence="1">
        <location>
            <begin position="10"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="129" mass="14122" checksum="22FF311AA6372408" modified="2014-10-29" version="1">MKGNSNATNEELTAYAWQMRSFSLDGHDIIDVRDYEIALSVNRTQIDGRICNGFGGSVQYVNSSTIKGQQIAFTTALCTAPTRGPIMMEVEDAFKNGLNNGMTISKEGDTLVLKDVVTNSTFTYGKPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MS95</accession>
    <name>A0A075MS95_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF2203 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01975</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700686.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MS95"/>
    <dbReference type="STRING" id="1459636.NTE_01975"/>
    <dbReference type="GeneID" id="41597723"/>
    <dbReference type="KEGG" id="nev:NTE_01975"/>
    <dbReference type="eggNOG" id="arCOG05495">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_137908_1_0_2"/>
    <dbReference type="OrthoDB" id="7857at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018699">
        <property type="entry name" value="DUF2203"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09969">
        <property type="entry name" value="DUF2203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016498">
        <property type="entry name" value="UCP016498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="133" mass="15261" checksum="42496D3BC00BD836" modified="2014-10-29" version="1">MFTLYTPQTANKALPEVKRMFAGIVAQKNHVMVLQQELQMIVDSGSDFERFMKKKQELNTAITNLYKAIETLEATGVMLKSVDEGLLDFPSKRFDEEVWLCWKAGEDEIKFWHGKDEGFMGRKPLETTGVIEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSE1</accession>
    <name>A0A075MSE1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycogen debranching enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01977</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700688.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSE1"/>
    <dbReference type="STRING" id="1459636.NTE_01977"/>
    <dbReference type="GeneID" id="41597725"/>
    <dbReference type="KEGG" id="nev:NTE_01977"/>
    <dbReference type="eggNOG" id="arCOG03287">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG05512">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_331686_0_0_2"/>
    <dbReference type="OrthoDB" id="7795at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032790">
        <property type="entry name" value="GDE_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34987:SF6">
        <property type="entry name" value="ALPHA-L-RHAMNOSIDASE SIX-HAIRPIN GLYCOSIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34987">
        <property type="entry name" value="C, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06202">
        <property type="entry name" value="GDE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycogen debranching enzyme C-terminal" evidence="1">
        <location>
            <begin position="439"/>
            <end position="789"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="873" mass="97424" checksum="744CAB6F7A546C08" modified="2014-10-29" version="1">MTRALDSIHTSLSYVKGSLKNATVVVGGEEHKAFSFSLLNPPVPLGGNVVSLDVFVDDIPVQKKMVYIATQESIVNASSLSDSRPIAFKPFQSARFLVINDSWLGRGKHRITLVSKLEGFELIAIPFTFSDTAGRQNERIVLPSDLSVDLVAVSDSVFRNFSTPLALSGKRAYILCSSNGSLSAPWEWMGVKYDNGGLYVPPARVFGRIIVEISMDDGVRKRLPNFVVWSRHENGVLTTRHELGGIEVQRKLFVPPESRGFVIAMEMRMSTGGLSNGSRKKRKLRIHFIIDGNITSYGLAAVSQSNVARFDTKNQCLHIRTAHQKAAQYFGTIGVAPKMLSPCNILVNSFDNDTELSYDVEVGNKEPVQVALVGAGSFTSARGSLAEFLHMRNHYQELLQETEQSFRDHASSTVVLRQSGSTPGNDMARLLSAYEKAKASLQYLKGEYDGLGEGICAGLPRFPNYWARDTGWSLRGYLAIGDYSFARTTIDNFLSHQARNVPGVTRGELPMIISGKAFLHSTTYGSADSTFLFPWAIREYALATGDIAYLKKRWKQIVDLVDWGLHKDLDNDGFVEHGFSGIAMKLPIQDSTWMDHIDRRKSANDVQALFYESLVVGSDLARLAGDAESEKRWAHRADELKRKINEEYWRPDAGFYFDTIRKDLTKDASIRPNALVLVLAGVAEEERARLVVERLEKDDITTPWGVRTLSNLDLKYQPALYHDGAVWPLVTGWMALAELRLGRREAAYRYVRMMADRILEENGMFAETYRGDRPEPFNSCILQAWSAGMYVKAFLDMALGMKIDMVNDTVSINPQIPESLKAGCGKMEFSGPLFVKGRQSKFSMTLDVENEKLSVDFGNLPKKPQVQSSRYAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSG6</accession>
    <name>A0A075MSG6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158384914.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSG6"/>
    <dbReference type="GeneID" id="43502544"/>
    <dbReference type="KEGG" id="nev:NTE_00207"/>
    <dbReference type="HOGENOM" id="CLU_3162925_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="47" mass="5280" checksum="18E1E63CD68880FC" modified="2014-10-29" version="1">MSEDVRKDEEAKKPQSAPAELKQNPHDPTKVNKKDLEHLQNPKEGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSR7</accession>
    <name>A0A075MSR7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Stress-induced acidophilic repeat motif-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700811.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSR7"/>
    <dbReference type="GeneID" id="41597864"/>
    <dbReference type="KEGG" id="nev:NTE_02136"/>
    <dbReference type="eggNOG" id="arCOG12348">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2490277_0_0_2"/>
    <dbReference type="OrthoDB" id="106906at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="86" mass="9012" checksum="39D96F27242CA92D" modified="2014-10-29" version="1">MPSSERDRGSKRGLASADAQTRKRVARAGGEAPHEERGLQAADEQTRERVAREGGQASHGGGSSNEGSQGGSEKRGYASRSEEESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSU1</accession>
    <name>A0A075MSU1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Roadblock/LAMTOR2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00337</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699401.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSU1"/>
    <dbReference type="STRING" id="1459636.NTE_00337"/>
    <dbReference type="GeneID" id="41596233"/>
    <dbReference type="KEGG" id="nev:NTE_00337"/>
    <dbReference type="HOGENOM" id="CLU_1987509_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="125" mass="13790" checksum="7E40DF3EF9C74CBC" modified="2014-10-29" version="1">MTGASNSDLNSILEMRADVTFAGLVLKGKPLQMQLRPGVPMPSENDMQRMLLQVEMFSSMISTNEKVAGETQFILISHSNVKVLIVPLVANNNNNTGKTLVVTFTQFKGIESLVRLILERAKTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSW4</accession>
    <name>A0A075MSW4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02628</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701201.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSW4"/>
    <dbReference type="STRING" id="1459636.NTE_02628"/>
    <dbReference type="GeneID" id="41598321"/>
    <dbReference type="KEGG" id="nev:NTE_02628"/>
    <dbReference type="eggNOG" id="arCOG01117">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_170329_2_0_2"/>
    <dbReference type="OrthoDB" id="8136at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription regulator AsnC/Lrp ligand binding" evidence="1">
        <location>
            <begin position="7"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="83" mass="9465" checksum="11B7811C090BE171" modified="2014-10-29" version="1">MPSSAYILINCELGCENAVIDELKTLPGVVEASQIYGSTFDIIVKVWAETEERLKEIINRRIRRIEKVKATQTMMVVELHSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MT27</accession>
    <name>A0A075MT27_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01893</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700623.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MT27"/>
    <dbReference type="STRING" id="1459636.NTE_01893"/>
    <dbReference type="GeneID" id="41597644"/>
    <dbReference type="KEGG" id="nev:NTE_01893"/>
    <dbReference type="HOGENOM" id="CLU_2839205_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="65" mass="7853" checksum="A0394961524735A3" modified="2014-10-29" version="1">MPAKENSMYKTNEPLLTALQRNDLEELRRKVNGEKGTYFDFYSVAKKYCNRYEDMMRSHGIRREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MT59</accession>
    <name>A0A075MT59_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02249</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700903.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MT59"/>
    <dbReference type="STRING" id="1459636.NTE_02249"/>
    <dbReference type="GeneID" id="41597967"/>
    <dbReference type="KEGG" id="nev:NTE_02249"/>
    <dbReference type="HOGENOM" id="CLU_2340286_0_0_2"/>
    <dbReference type="OrthoDB" id="5850at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="97" mass="11353" checksum="977CB090D2C7B472" modified="2014-10-29" version="1">MSRIQIFKRNSTFVDLPDLVEEISNIGLEETLKKYYNPPFEHDAKSIVAGPSFMHYLNRLFKTQIAAGDILQFESSDYHKYFMFSPTGTWDEIIKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MT78</accession>
    <name>A0A075MT78_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RecA-superfamily ATPase possibly involved in signal transduction</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02363</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MT78"/>
    <dbReference type="STRING" id="1459636.NTE_02363"/>
    <dbReference type="KEGG" id="nev:NTE_02363"/>
    <dbReference type="eggNOG" id="arCOG01171">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023669_4_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051347">
        <property type="entry name" value="Circadian_clock_KaiC-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014774">
        <property type="entry name" value="KaiC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010624">
        <property type="entry name" value="KaiC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42926">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42926:SF1">
        <property type="entry name" value="CIRCADIAN CLOCK OSCILLATOR PROTEIN KAIC 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06745">
        <property type="entry name" value="ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01874">
        <property type="entry name" value="DNAREPAIRADA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51146">
        <property type="entry name" value="KAIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KaiC" evidence="1">
        <location>
            <begin position="15"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="261" mass="28902" checksum="DBC717AE7CDAF0E2" modified="2014-10-29" version="1">MGDSREVPERKMAKGRAPTGISEFDAMLNGGFMKGDCVLVTGAAGTGKTNLALQFLYNGVVKYGENAVYVTFEQMPDQIYRDAKNLGMNLEKLEEENRLKVISTSPDVLVQNQDMISEFSSERAERIVIDSISYFELSRKNSVRDEIYTLIRYLKTKGATSMLLHEAQADTAHGFGSYDHGLSFLADTVVVLKYVEIESAIRRAVAILKMRGSDHEKTLREIRITSKGIEVGGSFEQWEGVLSGAPHKSFALRVSKAFGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTC4</accession>
    <name>A0A075MTC4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative CoA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01989</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700697.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTC4"/>
    <dbReference type="GeneID" id="41597736"/>
    <dbReference type="KEGG" id="nev:NTE_01989"/>
    <dbReference type="eggNOG" id="arCOG04227">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112567_0_1_2"/>
    <dbReference type="OrthoDB" id="42776at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33303:SF2">
        <property type="entry name" value="COA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33303">
        <property type="entry name" value="CYTOPLASMIC PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA-binding" evidence="1">
        <location>
            <begin position="13"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="139" mass="15623" checksum="FE07D33C71EEB4B7" modified="2014-10-29" version="1">MNTDSCSDAEIREFYKLKNIAVVGMSKADGKPANYVPKYLIEQGYNVIPVNPTAPEIMGRKSYPNVSSVPDQIDIVDVFRPSDDVLPVVMDAVKKAGIKVVWMQLGIYNEQAEKLAKEKGIKVVYNRCMLEEHQRLFGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTE3</accession>
    <name>A0A075MTE3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00493</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699521.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTE3"/>
    <dbReference type="STRING" id="1459636.NTE_00493"/>
    <dbReference type="GeneID" id="41596366"/>
    <dbReference type="KEGG" id="nev:NTE_00493"/>
    <dbReference type="HOGENOM" id="CLU_270384_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045392">
        <property type="entry name" value="DUF6519"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20129">
        <property type="entry name" value="DUF6519"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="1204" mass="132568" checksum="6D993F9102FF12E4" modified="2014-10-29" version="1">MTQDITRSTFRKGNHYSSVDMQQGRVQVDADWNEQNDIRSHHEHTFLSDLIGKSGTMQQDDGFEISTFLFKWSDIKTKAEVDALDVKKRIQYLKDTESLRGFLRGNFGLLWISDSLPFTASGDTITITNGDHKATLERANTGATKVLLKVDGGSTVLYEFPSQAGQVSVPNYMIRRGNYYVDGILCENDYDMEASRQPDIDVSDAKFYLFDWPGANGIPAVRDAVAGFVAGMIPSMPDTRAMTVAFDSGNANKLVVSMPASGSPVKATLERAGGKVTLQGPAGAVAAEIIAENNGKVWHVLGNPSLPKKDGKYLAYLDVWDRNVTFLDDAYIREKALGGPDTSTRTRTAWQVKLDLLTEGNDVPDRCDAQSLVNGFSPRPGKLKARAQPTVPPANSCDLYETAGYRGLENHLYRVEVHNGGKPQEATFKWSRDNGVVVSTIKFGAIQNTIELGSRGRDANLDFGPSDWIEIIDDVHEELGIPGTLVQIKTVKGLIVEYDSATIRGHAITRVNFPQNPKARRWDRSGNSDILLSSASDKDADGYILLEDGVQIKIITEAADEGLRTGDYWLIPARANSSESVEWPTMPGNSADPLALPPAGVAHHYAPLAIVQYSGGKYSTKDEWDVRSFFSSVADLVTLHYAGGDGQEALPDNHLAAPLRVVALLGRTPLDKTYLGSKATVKFALAKYPQVPPGSTGGLSLTEDGPLQLSQSVQVVNGIAKCYWTLGEGMVDQQVEATLSDCAGLPALHFNAKQRLSFYYISGDGVEVPPGVSVTLAAGVAIGNTSVSSTDYEVRFEKVPPNAGGNLSSDRDNPANGIASVELKLDGTSEICQVKAELWYRKSAAAQLHKASIQPLYFNVRLQSAVSAANTGILELTVPQKSLPMPLVYGPFEHYLPRLSVPPAVMLGLAIEEKYLAWLNADEIKYLMDFIIKHSKRQTINKWEIRSALYDVLKRLTEEKQLDKKEVDLFLSIYDRLFMQAAISKKEADFFLKIAQKVVTNTSQFLEILKKLVERKRHPSKESRVEYTEDYPSKDDLRFKPVMITPTSFKVHLWIDPKVALKKEMVLLRWWAVPPEEKRPQYGEPISIGFDKAVYDIPLTTRDPVAVVVFAIDPLNTEDSLKATFAISQTGTVPVTVPLELKRNDKLGRYGAVLKITTMRGGGKITTADGKTFQFNGKTQQTMTATYDEEPSISGRALYKILSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTG1</accession>
    <name>A0A075MTG1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700979.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTG1"/>
    <dbReference type="STRING" id="1459636.NTE_02346"/>
    <dbReference type="GeneID" id="41598062"/>
    <dbReference type="KEGG" id="nev:NTE_02346"/>
    <dbReference type="eggNOG" id="arCOG02391">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_15_2"/>
    <dbReference type="OrthoDB" id="2830at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052048">
        <property type="entry name" value="ST_Response_Regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43228">
        <property type="entry name" value="TWO-COMPONENT RESPONSE REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43228:SF1">
        <property type="entry name" value="TWO-COMPONENT RESPONSE REGULATOR ARR22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="1">
        <location>
            <begin position="8"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="126" mass="13743" checksum="A2D6923212616E9B" modified="2014-10-29" version="1">MSSRSSTKILVVDDALFMRTILKDILQSNGFTNILEAGDGAAAIDAYRKNKPDLVTMDINMPGTDGIQALKSIISIDPTAKIIMVTSVEQKQIMQEAIKVGAKDYVVKPFDRAMVAAVLNKVMRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTL2</accession>
    <name>A0A075MTL2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methylase involved in ubiquinone/menaquinone biosynthesis</fullName>
            <ecNumber evidence="1">2.1.1.163</ecNumber>
            <ecNumber evidence="1">2.1.1.201</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02923</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.163" evidence="1"/>
    <dbReference type="EC" id="2.1.1.201" evidence="1"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTL2"/>
    <dbReference type="STRING" id="1459636.NTE_02923"/>
    <dbReference type="KEGG" id="nev:NTE_02923"/>
    <dbReference type="eggNOG" id="arCOG04348">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037990_12_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008425">
        <property type="term" value="F:2-methoxy-6-polyprenyl-1,4-benzoquinol methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043770">
        <property type="term" value="F:demethylmenaquinone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01209">
        <property type="entry name" value="Ubie_methyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0830">Ubiquinone</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="233" mass="25907" checksum="26A1BBB93A325A34" modified="2014-10-29" version="1">MSGLGSQYWPEVIEVLRSIVPVYNKVNRVISLGKDEEYRHHAIKGRVMPENLVLDAGSGFGNMSRVALAEAGGNARIVMYDPLPEMLANTRTFFAGAYRPSLSSGIFEHMPFQDDTFDAVLCGYSLRDAIDLRKAIAEMHRVLVPGGRLIIVDLGKPDGAFKRWMVATYLKHFLGIFAYMAAGKPGLKFTTLYGTFLRWPKNSELEAMLAEKFSKVVFDKGMLDGAIMVAAYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTM1</accession>
    <name>A0A075MTM1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative esterase of the alpha-beta hydrolase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_02066</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226986937.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTM1"/>
    <dbReference type="GeneID" id="41597802"/>
    <dbReference type="KEGG" id="nev:NTE_02066"/>
    <dbReference type="HOGENOM" id="CLU_1529151_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF57">
        <property type="entry name" value="BLR7027 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="4">
        <location>
            <begin position="60"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF84122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="175" mass="18829" checksum="6B339DAE8D0E9150" modified="2014-10-29" version="1">MSQATSKALPVEDETSVEVRQLRLDPRSSTISASTLGTTAAATATNVRIDPGRMVPQVALVLSGGGAHGDFEVGVVNYLYRLRKIAPKIICGTSVGAINALKLAEGEPKEKMANRDSDGHLQGLAGLEEIWLLLKKNGNMYKDAIDTSKFEKDAKELLEDVTATAAPLYFWVLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTZ0</accession>
    <name>A0A075MTZ0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00634</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699630.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTZ0"/>
    <dbReference type="STRING" id="1459636.NTE_00634"/>
    <dbReference type="GeneID" id="41596497"/>
    <dbReference type="KEGG" id="nev:NTE_00634"/>
    <dbReference type="eggNOG" id="arCOG01841">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1718125_0_0_2"/>
    <dbReference type="OrthoDB" id="10797at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="165" mass="18261" checksum="B6E3F1239A85D704" modified="2014-10-29" version="1">MAKYTKKYSTGRSIGFIVPLLALMLVGAMYVMAARNGQNNGASFILITIAAGFVIYWVREIRKMSGPPEQKVIMPRDAEQQKKDWVYDLIKNNDGAMVFVAEVPGPEDQINVRLSEGVLKIKGGQNFSKDVQLDPTATTPAAAAEMGISDYKYRNGVLTIRMQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MU29</accession>
    <name>A0A075MU29_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ammonia monooxygenase/methane monooxygenase, subunit C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701615.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MU29"/>
    <dbReference type="STRING" id="1459636.NTE_03139"/>
    <dbReference type="GeneID" id="41598798"/>
    <dbReference type="KEGG" id="nev:NTE_03139"/>
    <dbReference type="eggNOG" id="arCOG08699">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1444620_0_0_2"/>
    <dbReference type="OrthoDB" id="373357at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22188">
        <property type="entry name" value="arch-AMO_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.50">
        <property type="entry name" value="Particulate methane monooxygenase subunit c2. Chain: C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006980">
        <property type="entry name" value="NH3_CH4_mOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023349">
        <property type="entry name" value="NH3_CH4_mOase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04896">
        <property type="entry name" value="AmoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="187" mass="21146" checksum="16DFDC1C03F50CB0" modified="2014-10-29" version="1">MALIPSLIPKELEIQRLKRIYVMIIVMLSVTASADLGYFVDTSLNQTIIRDSAFTPANWWLYSSLIALPLGWGIIAVYDRRVPVMRGPGNALNTGLKMAIIGYLASMFAIGVNELWHFWFVEEIFAVPPHWIFNMGIFVALMGSLAYLVRVYARLVELGVEMPARNPYLAEMYKLALEGKLYSRSIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MU39</accession>
    <name>A0A075MU39_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tissue inhibitor of metalloproteinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MU39"/>
    <dbReference type="STRING" id="1459636.NTE_02625"/>
    <dbReference type="KEGG" id="nev:NTE_02625"/>
    <dbReference type="HOGENOM" id="CLU_113253_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008993">
        <property type="entry name" value="TIMP-like_OB-fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50242">
        <property type="entry name" value="TIMP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="170" mass="17970" checksum="C3818DC5043E5CA4" modified="2014-10-29" version="1">MLGLAATLFEVPKAHACSCVGSISPGEQFEKSTAVFAGKVADIEAGDYSNTVHFDVERAWKGVSTTTLALTTSGSSDSCGYDFEKGKEYVVYAYSSDESSLRTSTCSRTQLVAYAYDDLAYLGAGYTPAPGQPATVAKEPGDPLLPFIGIGAAVTAAIVLFTRRKSKRQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MU60</accession>
    <name>A0A075MU60_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_02640</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385525.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MU60"/>
    <dbReference type="STRING" id="1459636.NTE_02640"/>
    <dbReference type="GeneID" id="41598333"/>
    <dbReference type="KEGG" id="nev:NTE_02640"/>
    <dbReference type="eggNOG" id="arCOG01259">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_9_2"/>
    <dbReference type="OrthoDB" id="10157at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44196">
        <property type="entry name" value="DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44196:SF1">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="4">
        <location>
            <begin position="2"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF84683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="269" mass="29260" checksum="78C15EA95321FFFD" modified="2014-10-29" version="1">MKSVIVTGASSGIGRAASSRLANAGYRVYGLARSYDKLQAMAGELANFVPVEFDVTKPDKFDKVLDPIIASSPSGIFGLVNNAGYVEPGAIEDLSMESIRMQFETNFFGLVGVTKKILPSMMAQKEGRIVNVSSMAGMVSLPTIGMYCATKHALEAFTEALRMELWNTGIKVASINPGIIETNIHFVTDEKVSQLKNSRFAKAYAKYLKETPRGLPSSIVADAIYDAVSTSKPKYRYLLGSAREKAGVRLRRIAPDDIIHSLVAKRVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MU74</accession>
    <name>A0A075MU74_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385621.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MU74"/>
    <dbReference type="GeneID" id="41598832"/>
    <dbReference type="KEGG" id="nev:NTE_03174"/>
    <dbReference type="HOGENOM" id="CLU_2433971_0_0_2"/>
    <dbReference type="OrthoDB" id="377990at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="94" mass="9908" checksum="A776B37ED73B1297" modified="2014-10-29" version="1">MLQFMRVLALGMTIFIASAVVIISNNTGLAYGHGCQAQGGCCTVGDACVEISASSPIYMMFAVVGAGAVMMLAFYGRSEQTRKSRLGAVFNIFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUM9</accession>
    <name>A0A075MUM9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02877</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701407.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUM9"/>
    <dbReference type="STRING" id="1459636.NTE_02877"/>
    <dbReference type="GeneID" id="41598557"/>
    <dbReference type="KEGG" id="nev:NTE_02877"/>
    <dbReference type="eggNOG" id="arCOG08781">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1965630_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="138" mass="16358" checksum="97A6054E78120238" modified="2014-10-29" version="1">MVNRKFADKPPMIAIQGACIDFEKEHARIMEFIGGLEWGAHTKGNVECSSAGKALGWDFFMLYFEPDFVEVLIDVYPDINKQEANTIEDRFVLWLAKIMKKKKLDYNLKLKDVPYEQTQGFRLNPDHYRNDEWMERYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUN3</accession>
    <name>A0A075MUN3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">K+-transporting ATPase, A chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NTE_00943</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUN3"/>
    <dbReference type="STRING" id="1459636.NTE_00943"/>
    <dbReference type="KEGG" id="nev:NTE_00943"/>
    <dbReference type="eggNOG" id="arCOG04804">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018614_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004623">
        <property type="entry name" value="KdpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30607">
        <property type="entry name" value="POTASSIUM-TRANSPORTING ATPASE A CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30607:SF2">
        <property type="entry name" value="POTASSIUM-TRANSPORTING ATPASE POTASSIUM-BINDING SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03814">
        <property type="entry name" value="KdpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="247"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="292"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIF83019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="322" mass="33551" checksum="DA12EFB0B5BB5137" modified="2014-10-29" version="1">MVMGPVASFLSIKQLGSNGGGYFSANSAHPFETFLMLVIPLSFPIAFAKLVGKGRGVSILIAMLAGFGVMLGIALVQASGPALLETRFGSFGSVLFNVGSLSTNTGAVASSLAGMSPSAVTGLFLGMFVQAIPGADGTGMMTMIVYVVLTLFIVGLMVGKTPEYLSMKISSHDIKLAVFIFLIHPALILIPTAVSLVSGDAQGVLGMQGQQTTAVTAAGYTQTLYEYTSAAANNGSDYFGTSANTPFWNYSTGIVMLLGRYIPIGLMLAIAGSFTVKDRKEVIEPIKTQGPLFIAVLVVMTFLLTALTFFPFLAIGPFSMGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUR0</accession>
    <name>A0A075MUR0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH arsR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701381.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUR0"/>
    <dbReference type="STRING" id="1459636.NTE_02845"/>
    <dbReference type="GeneID" id="41598527"/>
    <dbReference type="KEGG" id="nev:NTE_02845"/>
    <dbReference type="eggNOG" id="arCOG02611">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109676_2_0_2"/>
    <dbReference type="OrthoDB" id="28610at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056504">
        <property type="entry name" value="HTH_HVO_0163_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36216:SF1">
        <property type="entry name" value="HTH ARSR-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36216">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR, TRMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24266">
        <property type="entry name" value="HTH_HVO_0163_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="76"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="172" mass="19711" checksum="108BE810E766158D" modified="2014-10-29" version="1">MEELSETVSAQDLLLKLIEREPGIRYRELLRSTGFANGVLTYHLSALERASVIRVDRQQARITRYYPVNVPESESQVLGYIRHEPIREIVSFVLSQDMCTFAEIVEHTGKAPSTISAHLKRLKDAGILSVRYGEYQLYSLANKELIADVLSKYRQTFADKVVDNYVEMLDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUW6</accession>
    <name>A0A075MUW6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3108 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_01015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699922.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUW6"/>
    <dbReference type="STRING" id="1459636.NTE_01015"/>
    <dbReference type="GeneID" id="41596839"/>
    <dbReference type="KEGG" id="nev:NTE_01015"/>
    <dbReference type="eggNOG" id="arCOG08733">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1227690_0_0_2"/>
    <dbReference type="OrthoDB" id="10915at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.360.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049279">
        <property type="entry name" value="DUF3108-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21347">
        <property type="entry name" value="DUF3108_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3108" evidence="2">
        <location>
            <begin position="173"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF83089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="235" mass="25082" checksum="D7F21BAA4326A5A5" modified="2014-10-29" version="1">MTPKQQVAVMVGLFSALGIGVSVGIIAFGGGFSGGDAASILNPPTSADIYVIGAQVTDGLSMGYTVDSQGPPSLADAKVSITFAKAGDNSGSWRTTFNVVNGTQGTQNFDVMYSKELTKEGSISESARQYLEPIESSILAIRDMDYGGRDKYLVVGAPWNTIVTGSTTPITVKITSQEKVTTPAGTFDALVLSYKLNNNTSKIYVVKDLPMPVKAETYDINDQLYYKYELVSLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUX1</accession>
    <name>A0A075MUX1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA topoisomerase 1</fullName>
            <ecNumber evidence="3">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">DNA topoisomerase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NTE_02925</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type IB topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="3"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987022.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUX1"/>
    <dbReference type="STRING" id="1459636.NTE_02925"/>
    <dbReference type="GeneID" id="41598603"/>
    <dbReference type="KEGG" id="nev:NTE_02925"/>
    <dbReference type="eggNOG" id="arCOG08649">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009193_2_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.11.10">
        <property type="entry name" value="DNA Topoisomerase I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.15.10">
        <property type="entry name" value="Topoisomerase I, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.41">
        <property type="entry name" value="Yeast DNA topoisomerase - domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013034">
        <property type="entry name" value="DNA_topo_DNA_db_N_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013030">
        <property type="entry name" value="DNA_topo_DNA_db_N_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001631">
        <property type="entry name" value="TopoI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025834">
        <property type="entry name" value="TopoI_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014711">
        <property type="entry name" value="TopoI_cat_a-hlx-sub_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014727">
        <property type="entry name" value="TopoI_cat_a/b-sub_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013500">
        <property type="entry name" value="TopoI_cat_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008336">
        <property type="entry name" value="TopoI_DNA-bd_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036202">
        <property type="entry name" value="TopoI_DNA-bd_euk_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013499">
        <property type="entry name" value="TopoI_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051062">
        <property type="entry name" value="Topoisomerase_IB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10290:SF3">
        <property type="entry name" value="DNA TOPOISOMERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10290">
        <property type="entry name" value="DNA TOPOISOMERASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14370">
        <property type="entry name" value="Topo_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01028">
        <property type="entry name" value="Topoisom_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02919">
        <property type="entry name" value="Topoisom_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00416">
        <property type="entry name" value="EUTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00435">
        <property type="entry name" value="TOPEUc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56741">
        <property type="entry name" value="Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52038">
        <property type="entry name" value="TOPO_IB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="DNA topoisomerase I eukaryotic-type" evidence="10">
        <location>
            <begin position="169"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="104"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="453"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIF84963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="562" mass="65167" checksum="A154EF5BCDA8DFB9" modified="2014-10-29" version="1">MEEVAAAAPQPQVRIRWSSLVHRGVAFPPEHQPRGITISIMGEKIALNTDQEELVYAWAKKKDTHYVQDPVFQSNFLLDLKPMLPEKFRKMDLKISDFDFSQAYRLADEEKAIKEREKERIKNLPREEKKKMAEAKKAERERLKALYGKAIVDGQEVDIANWLVEPPGLFMGRGQHPLRGRWKPRVRPQDVTLNLGEDAPVPEGEWKEIVHDHTSTWLATWMENLTEKRKYVWLHDSSELRQGNDKAKYDKALKLAQQLGKVEKEIMRKMKGSNDRAATAAYLIFKLAMRVGDEKDPDEADTVGASTLRVEHIKFPQANGKQYIEFNFLGKDSVPWQKTLEVNSDDTRALYDNLRSFMKDKKPDQQIFDDINSRKVNAFFQTVMPGLTAKVFRTCIATKVVQQALVNPPIKVDRNSQESDKVYVAKSANLKAAIECNHKKGVDPKNPAAKKAAEKFEESIAKRKEAIAELEKQVTAANWKTEIQEKRLKERLAKLKMQLKLQQETRDYNLGTSLRNYIDPRVMRAWLNYVELDWTKVYTATLQRKFKWVEGYKEKNYARFYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUX4</accession>
    <name>A0A075MUX4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03433</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701867.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUX4"/>
    <dbReference type="GeneID" id="41599072"/>
    <dbReference type="KEGG" id="nev:NTE_03433"/>
    <dbReference type="HOGENOM" id="CLU_2433702_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="90" mass="10060" checksum="A810CE0B0BE7D3AA" modified="2014-10-29" version="1">MGQWEVYEAIQSLGGTATFSQIREYLQNKYCYCSESSTHDALKKLICNSLISGVPIAKGNSRRVYRITAEFPERNIIVIEKNGVSRSVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUY0</accession>
    <name>A0A075MUY0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02422</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUY0"/>
    <dbReference type="STRING" id="1459636.NTE_02422"/>
    <dbReference type="KEGG" id="nev:NTE_02422"/>
    <dbReference type="eggNOG" id="arCOG07348">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1880968_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="128" mass="14332" checksum="3AB346D8DFE844D0" modified="2014-10-29" version="1">MHTLIECSLEISIEPWKKLVVHEVIEYGFEDLVRIVLSQSRAAGGGIASMNWCNGLVFQHAVFPDTESVVQEKLKGTIHYSSVVLAKKDKFERQIVKENGTLNLVDVSANPIFFQLTETLKSAQGKRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUY5</accession>
    <name>A0A075MUY5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NTE_03443</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701875.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUY5"/>
    <dbReference type="STRING" id="1459636.NTE_03443"/>
    <dbReference type="GeneID" id="41599081"/>
    <dbReference type="KEGG" id="nev:NTE_03443"/>
    <dbReference type="eggNOG" id="arCOG04548">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1507315_0_0_2"/>
    <dbReference type="OrthoDB" id="23833at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050572">
        <property type="entry name" value="Fe-S_Ferredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43687">
        <property type="entry name" value="ADENYLYLSULFATE REDUCTASE, BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43687:SF6">
        <property type="entry name" value="L-ASPARTATE SEMIALDEHYDE SULFURTRANSFERASE IRON-SULFUR SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13237">
        <property type="entry name" value="Fer4_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="9">
        <location>
            <begin position="62"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="9">
        <location>
            <begin position="123"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="109"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIF85471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="179" mass="19750" checksum="397BF952F377FDF5" modified="2014-10-29" version="1">MPIDPEFPKNQQVIGKHSHSDGQHFHFVWGPGRTAEAADNEEVKKAYEARGEQLVPLGVHGTMVALDWDSCIADGACIEVCPVQVYQWYRTEQDVPGIELQNGTSAGSGEDHNREGRKDYTDKSDPIREHDCIWCMACVSVCPTQAIKVDQANLEYHEKAAGTFNEALAKSGAPPPHVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MV15</accession>
    <name>A0A075MV15_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Na+/H+ antiporter NhaD-like permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NTE_02968</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385583.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MV15"/>
    <dbReference type="STRING" id="1459636.NTE_02968"/>
    <dbReference type="GeneID" id="41598639"/>
    <dbReference type="KEGG" id="nev:NTE_02968"/>
    <dbReference type="eggNOG" id="arCOG00238">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011920_3_0_2"/>
    <dbReference type="OrthoDB" id="86089at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43302">
        <property type="entry name" value="TRANSPORTER ARSB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43302:SF5">
        <property type="entry name" value="TRANSPORTER ARSB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="262"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="291"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="332"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="370"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="Citrate transporter-like" evidence="8">
        <location>
            <begin position="14"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF85003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="437" mass="46943" checksum="6344E177F3868D25" modified="2014-10-29" version="1">MQEYVALGVFAVVYVLIIGRRRFGVPIWAAMLIGAALMVGLQVTGISDAFRAVNLEVIAFLFGMFSIVSALERAGVLRMIAVRMLARAKTPSQLLMIFVVGMGVLAAFLVNDTIALLGIPLAVHVARHAKIKPTILLLTLAFGITVGSVMTPIGNPQNLLIAIDSGMQFPFVTFLLYLSVPTVANLFVTYLILKAYFRKELPKMLEHAPAAEEEAEIVKEEEGDGAIHYNPRQARLAIYVTVATLAGFVISEFLHVLKVADFGLSVVAMLGAAALYALSSERTQILRKVDYSVLVFFAAMFVVTSAMWQSGAISIITGWLPDPSPADKAQSLGVITAASLSLSQVLSNVPFVALYDFVMTENGFGGEHVAQWLMLAAASTIAGNLTILGAASNVIVIEAAESRGVRAFSFFEFAKIGSVITAANIAIYYAFIVLIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MV73</accession>
    <name>A0A075MV73_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701600.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MV73"/>
    <dbReference type="STRING" id="1459636.NTE_03121"/>
    <dbReference type="GeneID" id="41598781"/>
    <dbReference type="KEGG" id="nev:NTE_03121"/>
    <dbReference type="eggNOG" id="arCOG06947">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_184933_0_0_2"/>
    <dbReference type="OrthoDB" id="9472at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="71" mass="8719" checksum="454C76C01BEAFE30" modified="2014-10-29" version="1">MGLLHREKNECEDCHTRFSSYEELVHHAHDAHKHHIIKCSDCGKLFLHEKDRLHHVKEERERKTDIRRHKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVM7</accession>
    <name>A0A075MVM7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_03266</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701726.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVM7"/>
    <dbReference type="STRING" id="1459636.NTE_03266"/>
    <dbReference type="GeneID" id="41598921"/>
    <dbReference type="KEGG" id="nev:NTE_03266"/>
    <dbReference type="HOGENOM" id="CLU_1754762_0_0_2"/>
    <dbReference type="OrthoDB" id="6852at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="6"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF85295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="157" mass="17563" checksum="460FB6FDD53E8089" modified="2014-10-29" version="1">MEISAALSTEEEKAKLDEKYEKLIDQFEQETAQYDRLSRVSAVATFGGVLASILGPLLYFQSAGVNPYHAFATGPALYIAIGGIIASKLVPKLAIMYASHKKHEVSRVKYKPVTGVCMCDLYQFRTHLRKMDKAENAGERMKHAKLASYYKHKMGWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVQ8</accession>
    <name>A0A075MVQ8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01321</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVQ8"/>
    <dbReference type="STRING" id="1459636.NTE_01321"/>
    <dbReference type="KEGG" id="nev:NTE_01321"/>
    <dbReference type="HOGENOM" id="CLU_200166_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="73" mass="8543" checksum="F3049D8A9260480C" modified="2014-10-29" version="1">MHNHINSGFFIHNNMLKPSKMRPIEKKKHQMPSYCMLCPDVATKEVLYELENCVVVQRYCDKCLPSAEYANPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVR4</accession>
    <name>A0A075MVR4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Small-conductance mechanosensitive channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NTE_01331</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700177.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVR4"/>
    <dbReference type="STRING" id="1459636.NTE_01331"/>
    <dbReference type="GeneID" id="41597130"/>
    <dbReference type="KEGG" id="nev:NTE_01331"/>
    <dbReference type="eggNOG" id="arCOG01568">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037945_1_0_2"/>
    <dbReference type="OrthoDB" id="31543at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049278">
        <property type="entry name" value="MS_channel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045275">
        <property type="entry name" value="MscS_archaea/bacteria_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_beta-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011066">
        <property type="entry name" value="MscS_channel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011014">
        <property type="entry name" value="MscS_channel_TM-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30221">
        <property type="entry name" value="SMALL-CONDUCTANCE MECHANOSENSITIVE CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30221:SF20">
        <property type="entry name" value="SMALL-CONDUCTANCE MECHANOSENSITIVE CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21082">
        <property type="entry name" value="MS_channel_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82689">
        <property type="entry name" value="Mechanosensitive channel protein MscS (YggB), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82861">
        <property type="entry name" value="Mechanosensitive channel protein MscS (YggB), transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="102"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Mechanosensitive ion channel MscS" evidence="9">
        <location>
            <begin position="119"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Mechanosensitive ion channel MscS C-terminal" evidence="10">
        <location>
            <begin position="195"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="289"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIF83399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="326" mass="35258" checksum="2860C4B748FFDE43" modified="2014-10-29" version="1">MAAEEGALSSGNSSATSVFGLPSTIDLFGVQVTPFSIILTLAIIVAGFAIAHAVRLVTLKYLGTRLPPDARKATGRTMYYGIIAIALLSALGVSGLDLSGLFLAGGFAGIVIGFATQSLFSNLISGIFLHIDKPMKIGDPVLITGKLPDVTGVVVEITALSSRLRMFDGTLVRLPNSDVFLSEIRNLSTVVARRIEFVVGVSYDSDTQKVMEIIRQSLKNTPLVLVEPEPDVYVNDLGASAVNINVWCWVPFVVWFDMKKQLVEQIKRELDSKGIEIPFPQQVVYVREEGRRRKKAPWRDVPSNTAQPGPGSSAGVNLEEAVDKND</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVT7</accession>
    <name>A0A075MVT7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVT7"/>
    <dbReference type="STRING" id="1459636.NTE_03229"/>
    <dbReference type="KEGG" id="nev:NTE_03229"/>
    <dbReference type="HOGENOM" id="CLU_1700202_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="154" mass="17490" checksum="3E602447F352A334" modified="2014-10-29" version="1">MFFSTKERKDSRKICKVCKTKIIPWINGGTKKLVALSAGAFIASALFLWISVNLYSYYVYDYADYQKNASLDPPFFGGRIHFFDTVYPYVVFVGASSAGLAAIGIISLLLMRRYRHRMNNLWLLLSISSILLVSFFALLYYANLSPIILNPFSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVV5</accession>
    <name>A0A075MVV5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transcription factor, MBF1 like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_03357</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain fatty acyl-CoA assimilation regulator (ScfR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVV5"/>
    <dbReference type="STRING" id="1459636.NTE_03357"/>
    <dbReference type="KEGG" id="nev:NTE_03357"/>
    <dbReference type="HOGENOM" id="CLU_557373_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010359">
        <property type="entry name" value="IrrE_HExxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052345">
        <property type="entry name" value="Rad_response_metalloprotease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43236">
        <property type="entry name" value="ANTITOXIN HIGA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43236:SF1">
        <property type="entry name" value="BLL7220 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06114">
        <property type="entry name" value="Peptidase_M78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="84"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF85385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="489" mass="55251" checksum="354C15D2C930039E" modified="2014-10-29" version="1">MIKNERQYRITKSYIEKFSAELASLRESEISGKIDPLLLKLGREAIQNQVEELQKELTEYEDLRQGGRLPLIELHSLEQLPRALIKARISLGLSQRELADRLNIAEQQIQRWESTEYSSASLGKIKEVLRALNMASPEGLQLTTGRVPLSSFFKRMERVGLDRNFIMDKILPSSLANYLAEKNVDSSESDLMGLQAALRIGRVFHWSPEEIFGDAELKLNTAVIPEVRFKLPKGRNELRVNAYTFYAHYLASIIAQATEQLPRKAIPKDPYVIHETIIAKSGSLSVASLTRFIWELGVPVIALDDPGAFHAACFNINNRNVIVLKQRTSSESRWMFDLLHEVWHAAQDSKQKIHIASDPGAPEYSSQEEIVANLFAAAVLLGKNPQRLAELCRDVSSGDRSRMKEAIRIVAEKEGVRADILANYVAFRYSMEGDDSLWGIAENLQRKITQDPKEIMLNIFLEYADLGSLSLPDLDLLQQAIRPGEQRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MW38</accession>
    <name>A0A075MW38_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phasin protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700269.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MW38"/>
    <dbReference type="STRING" id="1459636.NTE_01445"/>
    <dbReference type="GeneID" id="41597240"/>
    <dbReference type="KEGG" id="nev:NTE_01445"/>
    <dbReference type="eggNOG" id="arCOG08754">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1727298_0_0_2"/>
    <dbReference type="OrthoDB" id="9008at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="154" mass="17169" checksum="4A3C6E9DA24774F6" modified="2014-10-29" version="1">MVDTSKSSKEDATTATSRAEVIEAVKDNYIRTVDEIAKVQPQYLQSISNLQLDYIQTTKNVIQTAFSVQKQVASNVNIPATPYADLFVKQANEITNNTIRAVGINNQLTINALDAARENLKIYNRSIDAVTDFGTNVAKAWTAFYTQSQQQFTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWU8</accession>
    <name>A0A075MWU8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PRC-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01673</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700451.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWU8"/>
    <dbReference type="GeneID" id="41597446"/>
    <dbReference type="KEGG" id="nev:NTE_01673"/>
    <dbReference type="HOGENOM" id="CLU_1302578_0_0_2"/>
    <dbReference type="OrthoDB" id="9507at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="211" mass="23958" checksum="D1F41BD84AC72464" modified="2014-10-29" version="1">MSKNKLDYVEWNELKGKEARGVDKSVDLGEIQGVGRTYVVTKKGVVDKDKFYIPKALAERYDGKEVWFNVSEGMKSEFRRDNPPSDEEYAKYRTTNSPTDIEDKIAVVTEIPVKEDAVVVESETMVDTGIQTEEQPVVVDWEKIIHKNVRSMDGEPVGNVVALYPDTIHVESQGSRMAYEIPKDEVKGFDGAEVRLKAPITDLERYMKRGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MX65</accession>
    <name>A0A075MX65_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribonuclease P protein component 1</fullName>
            <shortName evidence="6">RNase P component 1</shortName>
            <ecNumber evidence="6">3.1.26.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Rpp29</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rnp1</name>
        <name evidence="7" type="ORF">NTE_01829</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.</text>
            <dbReference type="EC" id="3.1.26.5"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Consists of a catalytic RNA component and at least 4-5 protein subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the eukaryotic/archaeal RNase P protein component 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.5" evidence="6"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700582.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MX65"/>
    <dbReference type="STRING" id="1459636.NTE_01829"/>
    <dbReference type="GeneID" id="41597594"/>
    <dbReference type="KEGG" id="nev:NTE_01829"/>
    <dbReference type="eggNOG" id="arCOG00784">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107020_2_1_2"/>
    <dbReference type="OrthoDB" id="39019at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030677">
        <property type="term" value="C:ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.210">
        <property type="entry name" value="Ribonuclease P/MRP, subunit p29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00754">
        <property type="entry name" value="RNase_P_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036980">
        <property type="entry name" value="RNase_P/MRP_Rpp29_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023538">
        <property type="entry name" value="RNP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023534">
        <property type="entry name" value="Rof/RNase_P-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002730">
        <property type="entry name" value="Rpp29/RNP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01868">
        <property type="entry name" value="RNase_P-MRP_p29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00538">
        <property type="entry name" value="POP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101744">
        <property type="entry name" value="Rof/RNase P subunit-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF83889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="88" mass="9193" checksum="C3208ADB5E8F97FD" modified="2014-10-29" version="1">MITAVNILAHELIGLDAKIIESTNTALAGLAGTIVFETKNTLAIRSGSATKIIPKAAAKKIKIATQNGACFISGSSMIARPEDRISRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MXC4</accession>
    <name>A0A075MXC4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphatidylserine/phosphatidylglycerophosphate/ cardiolipin synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_01895</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700624.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MXC4"/>
    <dbReference type="STRING" id="1459636.NTE_01895"/>
    <dbReference type="GeneID" id="41597645"/>
    <dbReference type="KEGG" id="nev:NTE_01895"/>
    <dbReference type="eggNOG" id="arCOG02039">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1346362_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016891">
        <property type="term" value="F:RNA endonuclease activity producing 5'-phosphomonoesters, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00138">
        <property type="entry name" value="PLDc_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051406">
        <property type="entry name" value="PLD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43856">
        <property type="entry name" value="CARDIOLIPIN HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43856:SF1">
        <property type="entry name" value="MITOCHONDRIAL CARDIOLIPIN HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="4">
        <location>
            <begin position="88"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF83954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="203" mass="23284" checksum="0BA79ED3E98F9934" modified="2014-10-29" version="1">MPIERTNESGRHVVEQLFGARRSALICSPYISSEYAKKITGLAARGVLVKVLTSDKNVESDFHIREFFAEAKRKEKLDTLKTLVISHRMSFEHSKMYIIDDEYAVMGSANLTRAGMWENGETIDVYRSHRDVQLAREAFESAWKDALASAFGNKSNTYQHTSTYPRQGTRANYQIHERTGSKKVEDRDSIFDVIKRELRSLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MXJ1</accession>
    <name>A0A075MXJ1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative nucleoside kinase, CMP and AMP kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NTE_03303</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701756.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MXJ1"/>
    <dbReference type="STRING" id="1459636.NTE_03303"/>
    <dbReference type="GeneID" id="41598956"/>
    <dbReference type="KEGG" id="nev:NTE_03303"/>
    <dbReference type="eggNOG" id="arCOG01038">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079096_0_0_2"/>
    <dbReference type="OrthoDB" id="8730at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020618">
        <property type="entry name" value="Adenyl_kinase_AK6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12595:SF0">
        <property type="entry name" value="ADENYLATE KINASE ISOENZYME 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12595">
        <property type="entry name" value="POS9-ACTIVATING FACTOR FAP7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13238">
        <property type="entry name" value="AAA_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF85332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="194" mass="21449" checksum="82C8ED875E264992" modified="2014-10-29" version="1">MKKAVVRLVITGNPGVGKHTSAQIVARELKAEIIDINRVALDNGAVLEKTGKGIEIDTKKASKIVASMLNKKKKSSFVIVGHLAPYVVKPAGIDMVAVLRRSPRKLEESLLERKYIQEKINENVSAEILGISLYDSIKAFGKRKVAEFDTSGKTPEQTAEEIVATVQKEKPRRSGSVDWLAVISEEEVQRYFAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MXN3</accession>
    <name>A0A075MXN3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Arcadin 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02002</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700708.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MXN3"/>
    <dbReference type="STRING" id="1459636.NTE_02002"/>
    <dbReference type="GeneID" id="41597749"/>
    <dbReference type="KEGG" id="nev:NTE_02002"/>
    <dbReference type="eggNOG" id="arCOG10524">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2010163_0_0_2"/>
    <dbReference type="OrthoDB" id="6907at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="107" mass="12023" checksum="ED2BEEBCBF377C85" modified="2014-10-29" version="1">MKREFIVARIEASQDGSPYVYVTFNDPKDYKPDRPTNPFGQNTMAFSSIEDMMKNMPKVIANMPGMFGGGLTDTPIMKMSMKEYQDMGIKVGEKVTIEIQKIESSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MXS3</accession>
    <name>A0A075MXS3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PrgI family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03379</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701820.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MXS3"/>
    <dbReference type="STRING" id="1459636.NTE_03379"/>
    <dbReference type="GeneID" id="41599025"/>
    <dbReference type="KEGG" id="nev:NTE_03379"/>
    <dbReference type="HOGENOM" id="CLU_1656807_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="159" mass="17935" checksum="BF49B73E02446734" modified="2014-10-29" version="1">MVGQVDVLWFESMGVFSEPIFNFSFVRLTLRQVGTLFGGLLFAYALSTGLDQSVSGAAIACLALLVTFYRPRVMPLEQYFVAATRFLAAKNQRVTEKQRVALLMANNVAEVSEPESESNRARYLEKEPLDKGTSGFFEKSRIERRFLSSSFPFGRKKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MXT8</accession>
    <name>A0A075MXT8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02052</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MXT8"/>
    <dbReference type="STRING" id="1459636.NTE_02052"/>
    <dbReference type="KEGG" id="nev:NTE_02052"/>
    <dbReference type="HOGENOM" id="CLU_2839493_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="65" mass="6881" checksum="6C33BA758C30EF66" modified="2014-10-29" version="1">MNAAEFCPECNEAVLWKCSSCDRENDKSIHTSHPVESEAPPSTRAASVVGAILTMVSGMSVALTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MXZ3</accession>
    <name>A0A075MXZ3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Kef-type K+ transport system, membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NTE_03484</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="AIF85512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="GeneID" id="41599112"/>
    <dbReference type="KEGG" id="nev:NTE_03484"/>
    <dbReference type="eggNOG" id="arCOG01953">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005126_7_1_2"/>
    <dbReference type="OrthoDB" id="12029at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:proton transmembrane transport"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:sodium ion transport"/>
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        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43562">
        <property type="entry name" value="NAPA-TYPE SODIUM/HYDROGEN ANTIPORTER"/>
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    </dbReference>
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        <property type="entry name" value="SODIUM ION_PROTON EXCHANGER (EUROFUNG)"/>
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    </dbReference>
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    <keyword evidence="9" id="KW-0739">Sodium transport</keyword>
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            <end position="27"/>
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        </location>
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        <location>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
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            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
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            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
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            <end position="370"/>
        </location>
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        <location>
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            <end position="395"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="413" mass="43200" checksum="5A69C68305709055" modified="2014-10-29" version="1">MAVEEASTTFIHVIITIGVLLFAAKIFAELFARFKLPIVLGELTAGIVVGPFALGAIPIFNGEPLVVLDETVKHIGEISAIVILFIAGLEITPREFLRGGAAAFTVGSLGVIVPFFVGFYVFEAFGLPALESMLIATALTATSIAISIQVLTELGRMHSKEARLILGAAIVDDILAIAALSVVTTMVQTGNTTPDIMEIAFLIMKILGLFAALLIGAIFLIPKLLHTEKLWKSKGSIEGVATAAFFGAAGLAAFVGLSPIVGAFAVGMAVASTKVIHQMEEYVDKLQIIFAPLFFAIIGAQVDLRGVNLNVLYFSAILVAVAIVTKLVGTGLPSLLFLNKDKGKAMKVGIGMISRGEVGLIVAGVGVSAGAITSDVYTSVIIMVAATTIITPLWLKAAYKNEPAAVSDTTKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
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        <lineage>
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            <taxon>Nitrososphaerales</taxon>
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        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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            <dbReference type="EMBL" id="AIF84169.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="117" mass="13378" checksum="817DDC3746FD6546" modified="2014-10-29" version="1">MHFTKRCMSMNYELRGRLEKTADLLQSKFVPDFVEFADSQIAKEGFKISNERDFVIGGFLTLLLFEAAKSRPAGLTQDESIEVLEVAVKRFREIDRIIAKPKPKPKSSRKNRVGARS</sequence>
</entry>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">NTE_02286</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
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            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
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            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
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    <dbReference type="eggNOG" id="arCOG08688">
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    <dbReference type="Proteomes" id="UP000028194">
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    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="89" mass="9888" checksum="351B7C62F3BC8566" modified="2014-10-29" version="1">MSEGEDKLQYTGKVYLYSSGMPEDLIAISKEKLVERGVSEGDIVVLLDPVGVPEGSIMATIWPHYLSVAKVKRVREGSIYAPQLFNIQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MYT2</accession>
    <name>A0A075MYT2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">site-specific DNA-methyltransferase (adenine-specific)</fullName>
            <ecNumber evidence="2">2.1.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NTE_02372</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an N(6)-methyl-2'-deoxyadenosine in DNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15197"/>
            <dbReference type="Rhea" id="RHEA-COMP:12418"/>
            <dbReference type="Rhea" id="RHEA-COMP:12419"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90615"/>
            <dbReference type="ChEBI" id="CHEBI:90616"/>
            <dbReference type="EC" id="2.1.1.72"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the N(4)/N(6)-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.72" evidence="2"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MYT2"/>
    <dbReference type="STRING" id="1459636.NTE_02372"/>
    <dbReference type="REBASE" id="90015">
        <property type="entry name" value="M.NevSR1ORF2372P"/>
    </dbReference>
    <dbReference type="KEGG" id="nev:NTE_02372"/>
    <dbReference type="eggNOG" id="arCOG03416">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063430_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009007">
        <property type="term" value="F:site-specific DNA-methyltransferase (adenine-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1020.10">
        <property type="entry name" value="Adenine-specific Methyltransferase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023095">
        <property type="entry name" value="Ade_MeTrfase_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012263">
        <property type="entry name" value="M_m6A_EcoRV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012327">
        <property type="entry name" value="MeTrfase_D12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00571">
        <property type="entry name" value="dam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30481">
        <property type="entry name" value="DNA ADENINE METHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30481:SF3">
        <property type="entry name" value="DNA ADENINE METHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02086">
        <property type="entry name" value="MethyltransfD12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000398">
        <property type="entry name" value="M_m6A_EcoRV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00505">
        <property type="entry name" value="D12N6MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF84424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="291" mass="33358" checksum="EBA4C4157046124A" modified="2014-10-29" version="1">MLAQFCPERLDRYFEPFLGSGALFFHLVQSRPRFEAVLSDSNYELINVYLQVRDRTAELVELLQEHQQNYYAGRERYYYSVRDLEPTSGVERAARMIFLNRTCYNGLFRVNRSGRFNVPHGTYERPTICNRDALFSAAGVLARDGVRITHASYTQTTRSCAKGDVVYFDPPYLPLTKTANFVDYTRESFGWHDHVELAGEFVRLHDLGCAVILSNSDTRKIRDLYGDFTIKTARVERLINCNASRRTGQRELMILSSSPNAVVRARKKKKDVCRARLAAPATTAAVQAIRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N057</accession>
    <name>A0A075N057_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02846</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701382.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N057"/>
    <dbReference type="STRING" id="1459636.NTE_02846"/>
    <dbReference type="GeneID" id="41598528"/>
    <dbReference type="KEGG" id="nev:NTE_02846"/>
    <dbReference type="eggNOG" id="arCOG07573">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1880967_0_0_2"/>
    <dbReference type="OrthoDB" id="11874at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="135" mass="14507" checksum="406879966CAE1A42" modified="2014-10-29" version="1">MQTGSNQPVQEATASKPLVFGLTAAIVVGIIAPLVLPHVLHPSIFFHIILHIASLVIATFLSVVSLTAYMRAGGARTLYMTLGFIALGVSEVFYLFQAAGLLFFLNMPNLDIEFPHIIVLGMLSLFGLGVLKVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N072</accession>
    <name>A0A075N072_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">pyruvate, phosphate dikinase</fullName>
            <ecNumber evidence="3">2.7.9.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">NTE_02861</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SR1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PEP-utilizing enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.7.9.1" evidence="3"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701395.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N072"/>
    <dbReference type="STRING" id="1459636.NTE_02861"/>
    <dbReference type="GeneID" id="41598543"/>
    <dbReference type="KEGG" id="nev:NTE_02861"/>
    <dbReference type="eggNOG" id="arCOG01111">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015345_0_2_2"/>
    <dbReference type="OrthoDB" id="23397at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050242">
        <property type="term" value="F:pyruvate, phosphate dikinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.10">
        <property type="entry name" value="Phosphohistidine domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.189.10">
        <property type="entry name" value="Pyruvate Phosphate Dikinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018274">
        <property type="entry name" value="PEP_util_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000121">
        <property type="entry name" value="PEP_util_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002192">
        <property type="entry name" value="PPDK_AMP/ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010121">
        <property type="entry name" value="Pyruvate_phosphate_dikinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004531">
        <property type="entry name" value="PRK05878.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01828">
        <property type="entry name" value="pyru_phos_dikin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22931">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE DIKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22931:SF9">
        <property type="entry name" value="PYRUVATE, PHOSPHATE DIKINASE 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02896">
        <property type="entry name" value="PEP-utilizers_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01326">
        <property type="entry name" value="PPDK_N"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000853">
        <property type="entry name" value="PPDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="Phosphohistidine domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00370">
        <property type="entry name" value="PEP_ENZYMES_PHOS_SITE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate phosphate dikinase AMP/ATP-binding" evidence="12">
        <location>
            <begin position="23"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate phosphate dikinase AMP/ATP-binding" evidence="12">
        <location>
            <begin position="67"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate phosphate dikinase AMP/ATP-binding" evidence="12">
        <location>
            <begin position="302"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilising enzyme mobile" evidence="11">
        <location>
            <begin position="421"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilising enzyme C-terminal" evidence="13">
        <location>
            <begin position="519"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="753"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="777"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000853-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AIF84899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="894" mass="98582" checksum="42D561E09DFF9AF3" modified="2014-10-29" version="1">MSTSAIAKPIYFFDEADGKNRALLGGKGAGLAEMTKLGLPVPPGFIITTDICEKFYEAGKRLPDGLMDEVRKSIRRLETITGKKFGDAKNPLLVSVRSGAPVSMPGMMDTILNLGLNDQTVEGLAAQSGDVRFALDAYRRFIQMFGKIVLGADDRQFEKAFAGNNNNGISGEKALRQVIASFRSLCEATGKRFPDDPYKQIELAIDAVFRSWMGKRAVEYRRQYGITPDMANGTAVTVVAMVFGNMGNDSATGVVFTRNPETGEKKLYGDYLVNAQGEDVVSGKANPSHIDQMESEMPKVFSQLSQVCQKLENHFRECQDVEFTVERSRLYILQTRTAKMSAGASVKTSVDMYHEGLINKVEALQRIDPEGLEQILYPRIDSHVVRQKPVATGVAASPGAASGIAVFDVAKAEAMGKRGDKVILVREDTKPDDVPAFFQSVGILTTRGGKTSHAAVVARGMGKPCVVGCSQIEIDPEGASFSVNGRVAVTEGQKITIDGSTGRVYTVEVPTVAPEITSEFKEILQWSAEMKAIRIRANADTPESATLARKYGAEGIGLCRTERMFNQHDRIALFTKMVMAETEQEREKALAELERLQRSDFKAIFKEMQGLPVTIRLLDPPLHEFLPKEEDLMMQIFELKSEGGHRAEAEMLKREKMLRRVRELSEINPMLGHRGVRVGITFPEIYEMQIRAVCEAAADLTKEGVRVESQIMVPQVATVNELATVRHMFESVKREAEHRHRIKLKIVFGSMIEVVRSCLVADEIAHVADFLSFGTNDLTQATFSFSREDAEGKFLPFYLEKGVIAVNPFQSIDQKGVGRLMKMTIEMARKVKKDMEIGICGEHGGDPKSIEFCTTIGLDYVSASSHRIPIAILAAAQSAIRGNKSGKLSRFLTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N0M6</accession>
    <name>A0A075N0M6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Subtilase family protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_02994</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701499.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N0M6"/>
    <dbReference type="GeneID" id="41598664"/>
    <dbReference type="KEGG" id="nev:NTE_02994"/>
    <dbReference type="HOGENOM" id="CLU_379762_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S8/S53" evidence="2">
        <location>
            <begin position="296"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="710"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF85029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="729" mass="82331" checksum="E140F06AB0863ADF" modified="2014-10-29" version="1">MSSEDGFIGREVNYHGNDVFYTPIEEFVDFNPRKVFGGKKKVQYAKKSKKELVEDYEKTISRVSNSSIKDDEFAYFLLEFYSNPTSGRYARVLQEMNMTLLAFLDKSQKKALVQSPYADPLEVIVKESREIIKKIRPLDREEKIAPDLVNFAGNATVIVNTIPNIPAPKIEQHMSKIREFIQQHQGEPLNGLIDRENLRGSIIAKVNGETLRQLADDSSVILSVYKVPNVILSALGKRKRRITGDSTRAITASSMVTDDSSSTNRYEVIEIDSGVKILQDFQNHVVPLTALSQFPDGEDKDNHGTPIASLLLFGEGGKLKTSRVKVTSYKAWQESHDYDVKDLYTAMKFVLDNHKGRSRVFVSSLNYTFHDSFSEQETRKLELLIQSKNVCFVNSAGNIDDAASRRSVETRESIWKSARVFHPSDARTITSVGAYCRANGVDNNSYRLYPACFGRHNSEKIANKPEVLEFGGTLAVEGFGSTNIGVMAHSISGQVTSHYGTSMAAPLFARHLALLDFSLRDRVKNCETLKALAYSACKPTAAYDEFGGFGCLDTDELSTTSDRKVRVIFEGVFANMNEHRIPIHEIRIPIMVQPVKVTLFLVHSDNYSLPTTLDNYTAIMVDGTKGQQKLQLVREKGVNVGKWTHVKKAVYAYKKNSIGWWRFRLRPKLDNIPIQELSRLSLRYGGVLVIEAQRPPKGFLTLKEAMERERERSHTATESMESSYWDRYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N0Q4</accession>
    <name>A0A075N0Q4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative xylanase/chitin deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_03019</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701523.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N0Q4"/>
    <dbReference type="STRING" id="1459636.NTE_03019"/>
    <dbReference type="GeneID" id="41598689"/>
    <dbReference type="KEGG" id="nev:NTE_03019"/>
    <dbReference type="eggNOG" id="arCOG02508">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG02876">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG03439">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG08800">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_349729_0_0_2"/>
    <dbReference type="OrthoDB" id="10393at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059177">
        <property type="entry name" value="GH29D-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003410">
        <property type="entry name" value="HYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13290">
        <property type="entry name" value="CHB_HEX_C_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50825">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0858">Xylan degradation</keyword>
    <feature type="domain" description="NodB homology" evidence="4">
        <location>
            <begin position="49"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="3">
        <location>
            <begin position="306"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="342"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="345"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF85054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="931" mass="98512" checksum="C1CEF29BF50EE871" modified="2014-10-29" version="1">MTFQHLSGYGRASTLARITAVIAALVLVLNVVASAPIRAYAAPIPGACNCVIFRLDDIQDSWLNTVQNAVMDQFIAKNEKLTVGVIMNFIGTDTSVINKVRDGARSGNFEIASHAWNHVDHSKMTFQEQNSTLQQANEKMVTLWGTSPVTFIAPYNAYNNATLDALKSLKMKVLSAEFDQELPGIYDPDNPDSESNKVYRAIPGSNITDSRGIYHLPETIGFYNYETPEGVKNSVNTILSRINSTISSYGYAVVTLHPQDFAAKDANQVPLKPPQVNSAEIADLNTILDTVKAYGYTTKTFSEVLNLPPPPVIDSVPPVLTPPQDIHRVSNSSRTQIDDLGVYSVSDNSDPNPNVTKDVPPEGFPQGTTKVTWTATDKSGNSVQAFQYVTVRATADNVRPTIAITEPQKNSHVGGPLTGVNIPVKGQARDSETGIKIVEVRTNGTAYKTATPGAPGNWTTWSFELPITKPAAYNVTARATDFWGNFLWDYSLVTVTLGGTVDTKAPVFTIPPQDIQKEATGILTPISPGELGVGTVKATDDTDQNPVIVNDAPGGSEGSGFRVGVTIVHWNATDASKNVATWNQTVTIVAPSPVLPLPKAGAYNAPQTVKLTSLQEGSTIHYTTNGSTPTKNSTTYSGPIQISKSTDLKVVLVDPQDKLGNVTTLSYIIDTTAPTVSAAPVGGTYATAQSVILAPSETNNTKIYYTTDGSTPTTANTEYVTAISIGSTTTLKFVAKDSVGNLGPVVTESYVITIPSSGGGGGGGGGGGGGGGGGGGGGNSGGSVIIGGGVYTYPDSHFVQYPLDKIKFVNFGVVNPQNSNVVLTSATAGQQLDIYATFKNYQNNPQNYVYITQVEKDGVTIKIDWQTGAVDTGQTEIATRSWTPDEPGDYVVKVFVWDQLSGSPVALSEVGTSRISVTGPATTAAVATPQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N0V1</accession>
    <name>A0A075N0V1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative xylanase/chitin deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_03070</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N0V1"/>
    <dbReference type="KEGG" id="nev:NTE_03070"/>
    <dbReference type="eggNOG" id="arCOG02876">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_613395_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17957">
        <property type="entry name" value="Big_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0858">Xylan degradation</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="3">
        <location>
            <begin position="55"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF85104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="446" mass="47004" checksum="9F385ED770255354" modified="2014-10-29" version="1">MTSHSFPIGAPSSAERRKTANVVLSVILASIIIITASVFLVPAAESARAASTECNCVIFRLDDVQDSWIHDVQAKVLDAFISSDTKLTPGIIMNFYGSDSVVVDKISQGKDAGLFELALHGWNHVDYAQLSLAEQEQTLADANTKLQKINGQKSNIFITPYNSADADTLAAMKDTGLTILSADLYADGSPPFLAVTYPAADPSGIVSIPYTVYYVDEDKPSGQNAKTADQLYAEINDSIEAHGYAVVMLHPPDFAKHDDNNGQALNAVNQSQINTLQTLIDKIKADGKTITSYNELVSMTDNSDQSADAPSTSISNVSLHSGSAGASGSRQLMNTPSSTDPISGPNTIKPQIKITSLTAIPSVTEGSKVKVSGTASDDIAISKVEVRATLPDGSAGTTYVSAALTGDGEEWSFDLPLADPAFTKVVARATDASGNQQWAVVSLPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N0V5</accession>
    <name>A0A075N0V5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NTE_03075</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701565.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N0V5"/>
    <dbReference type="STRING" id="1459636.NTE_03075"/>
    <dbReference type="GeneID" id="41598738"/>
    <dbReference type="KEGG" id="nev:NTE_03075"/>
    <dbReference type="eggNOG" id="ENOG502N5MX">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079292_1_3_2"/>
    <dbReference type="OrthoDB" id="7631at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003416">
        <property type="entry name" value="MgtC/SapB/SrpB/YhiD_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049177">
        <property type="entry name" value="MgtC_SapB_SrpB_YhiD_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33778:SF1">
        <property type="entry name" value="MAGNESIUM TRANSPORTER YHID-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33778">
        <property type="entry name" value="PROTEIN MGTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02308">
        <property type="entry name" value="MgtC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01837">
        <property type="entry name" value="MGTCSAPBPROT"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="MgtC/SapB/SrpB/YhiD N-terminal" evidence="7">
        <location>
            <begin position="18"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF85109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="147" mass="15345" checksum="1DF265279513235C" modified="2014-10-29" version="1">MVLENLPTGYEIEFLINLGISLVAGFAIGAERESRGKAAGISTHCLVIGGAMIFTFLSSVVDPNSSSRIAAQVISGIGFLGAGLILKSEIDGKITNLTTAAAVWFAASIGMAIGYEYYFLAAVATAFAVGVPRIPHISKMMKKGEET</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N116</accession>
    <name>A0A075N116_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SnoaL-like domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N116"/>
    <dbReference type="KEGG" id="nev:NTE_03142"/>
    <dbReference type="HOGENOM" id="CLU_153137_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="2"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="107" mass="12348" checksum="2BD23F64FD23E177" modified="2014-10-29" version="1">MEYLEAVARQDFESARSYLKDNVSYVSPLNSFDNAEAYLKYNFSLHLPKLDIKKIFTDGDDVCLFHETTLTKPPATVFTSIWCHVDGGKISSIRVLFDPRPFLRPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N189</accession>
    <name>A0A075N189_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 16">ATP phosphoribosyltransferase</fullName>
            <ecNumber evidence="4 16">2.4.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">NTE_03195</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + ATP</text>
            <dbReference type="Rhea" id="RHEA:18473"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="2.4.2.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.4.2.17" evidence="4 16"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701660.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N189"/>
    <dbReference type="STRING" id="1459636.NTE_03195"/>
    <dbReference type="GeneID" id="41598852"/>
    <dbReference type="KEGG" id="nev:NTE_03195"/>
    <dbReference type="eggNOG" id="arCOG02208">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038115_1_1_2"/>
    <dbReference type="OrthoDB" id="33116at2157"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003879">
        <property type="term" value="F:ATP phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013820">
        <property type="entry name" value="ATP_PRibTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001348">
        <property type="entry name" value="ATP_PRibTrfase_HisG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013115">
        <property type="entry name" value="HisG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00070">
        <property type="entry name" value="hisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03455">
        <property type="entry name" value="HisG_C-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21403:SF10">
        <property type="entry name" value="ATP PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21403">
        <property type="entry name" value="ATP PHOSPHORIBOSYLTRANSFERASE ATP-PRTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01634">
        <property type="entry name" value="HisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08029">
        <property type="entry name" value="HisG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="GlnB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 19" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="14" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 19" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP phosphoribosyltransferase catalytic" evidence="17">
        <location>
            <begin position="50"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine biosynthesis HisG C-terminal" evidence="18">
        <location>
            <begin position="242"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00024861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="NCBIfam" id="TIGR00070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF08029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="AIF85224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="325" mass="36282" checksum="559AE5EAFE201B07" modified="2014-10-29" version="1">MPTVKFAVPKGSIEEVTFKLLEQAYQSISGRGRTYRVRLSDPEIEAKILRPQEIPTYVQEGFYDVGITGKDWIKEANADVEVLLDLEIGRVKQVIAVPSSFPYGSLDEMVSDFAKKGKTLRFSSEYLTTTAAYIKATKAYKKAYGDADPMIITPWLRVGDNKKVEIFLSFGATEAKPPEDVDAIFDITETGTTLVQNNLKIIDTVATSTAVLVANKKALKDEKKREKIADMVVLLKGVVEGRKKLHIFVNVKKENLDKLLKSLPALKKPTISPLSEDGWFGVNTVIDKEEFIRVVPKMRKLAQGLVVLEPRQILSLEEVNLDGYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N2A7</accession>
    <name>A0A075N2A7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytosine deaminase-like metal-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03546</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701945.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N2A7"/>
    <dbReference type="STRING" id="1459636.NTE_03546"/>
    <dbReference type="GeneID" id="41599164"/>
    <dbReference type="KEGG" id="nev:NTE_03546"/>
    <dbReference type="eggNOG" id="arCOG00692">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012358_1_0_2"/>
    <dbReference type="OrthoDB" id="42910at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050287">
        <property type="entry name" value="MTA/SAH_deaminase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005552">
        <property type="entry name" value="PRK07213.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43794">
        <property type="entry name" value="AMINOHYDROLASE SSNA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43794:SF5">
        <property type="entry name" value="CHLOROHYDROLASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="1">
        <location>
            <begin position="55"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="404" mass="42813" checksum="3202E173BC3F948A" modified="2014-10-29" version="1">MLVTIENASVLLGEHLEYIERGYIEIDYDNGIIRDAGAGKSSASPGKKLDAGGFLVMPGFINAHTHIADSIGKDIAAGRRLDARVHPVFGAKKKILEKSPPAHLAAMIKSSAVSMLQKGITTFADFREGGPEGVRLLKGAIAGLPIKCVALGRVDHYSSDPAEAEGLPTNAIAIAKQVLEVADGLGISGANENTDASLEQYGEMAAAKLVAIHAAESAETVQFSKDHTGRSEVERIMQHLKPDILVHMTHATCDEISLAAGKAGIVVCPRANGVLGAGLPRVAEMLKRGCLVAIGTDNVMLNSPDIFREMDYLWKASHAQGDFIEPRELVKMATANAAKMLGLNSGWIAPGRAADLVFLDKRHADLYPVHDPYTAIVHRASRDAVRAVMAAGRFVTAGGEGLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLE7</accession>
    <name>A0A075MLE7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00169</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLE7"/>
    <dbReference type="KEGG" id="nev:NTE_00169"/>
    <dbReference type="eggNOG" id="arCOG01055">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_159725_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038723">
        <property type="entry name" value="ArnR1-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14947">
        <property type="entry name" value="HTH_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ArnR1-like winged helix-turn-helix" evidence="1">
        <location>
            <begin position="5"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="105" mass="12318" checksum="2DE183DBDBF83FDF" modified="2014-10-29" version="1">MRKYRSNVDIAAAILKAAQNGQLKTRIKYESRTSMEQLNGYLEMLIETEMIEHRPKERLYCTTKKGMLFLNSYEQIWHILLRARDKKGHETAISIIKRSDSAKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLK4</accession>
    <name>A0A075MLK4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methylase involved in ubiquinone/menaquinone biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_00264</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699349.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLK4"/>
    <dbReference type="STRING" id="1459636.NTE_00264"/>
    <dbReference type="GeneID" id="41596175"/>
    <dbReference type="KEGG" id="nev:NTE_00264"/>
    <dbReference type="eggNOG" id="arCOG01792">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063529_0_0_2"/>
    <dbReference type="OrthoDB" id="8915at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053173">
        <property type="entry name" value="SAM-binding_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048711">
        <property type="entry name" value="WHD_Rv2258c"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45128:SF2">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45128">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21320">
        <property type="entry name" value="WHD_Rv2258c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="S-adenosylmethionine-dependent methyltransferase Rv2258c-like winged HTH" evidence="2">
        <location>
            <begin position="24"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="178"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF82346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="356" mass="38459" checksum="A8D8222F220BDF36" modified="2014-10-29" version="1">MSVAVDKTKLNKFVEKSATEWGAALGVLLTFAGDRLGLFKAMAGAGPLTPEELAGRTNTHPRIMREWLAAQAAGGIVTYNADSGTYELPQEHAIALIDENSPAYIAGAYQMITGLFKDEEKIIEAFKTGKGLGWGDHHHYLFQATERFFKPNYVANLTSSWIPALDGVEAKLKNGGGGAKVADVGCGHGSSTILMAKAYPNSKVIGFDFHKPSIEWARKEAEKESLKNITFEVAGSTDYSGDDYDLVTFFDCFHDMGDPAGAAKHVLQTLKKKNGSWMIVEPFANDKIEDNLNPLGRLSYSVSTVVCVPSSLSENGPALGAQAGEARIRDIVTGVGFSKFRRAAQTPFNLVFEAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLV1</accession>
    <name>A0A075MLV1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-grasp superfamily enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699257.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLV1"/>
    <dbReference type="STRING" id="1459636.NTE_00136"/>
    <dbReference type="GeneID" id="41596076"/>
    <dbReference type="KEGG" id="nev:NTE_00136"/>
    <dbReference type="eggNOG" id="arCOG00347">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075000_0_0_2"/>
    <dbReference type="OrthoDB" id="31247at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10900">
        <property type="entry name" value="PAC-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019151">
        <property type="entry name" value="Proteasome_assmbl_chaperone_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038389">
        <property type="entry name" value="PSMG2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35610:SF7">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35610">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09754">
        <property type="entry name" value="PAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159659">
        <property type="entry name" value="Cgl1923-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="322" mass="34986" checksum="C44F6E9F4B9507D7" modified="2014-10-29" version="1">MVKRGFASETTIHESYDGKTRIKQFLRVKATTNNNTANSRKHISLRPSLIAGFPGTGLVGSISANFIIERLDMHQIASVDSEFIMPTVTYIGDKLRHPFRIYADRKGSLYVIVCEAPLLPEGIHNIMDLVVSWAINNGIGEVITLDGIPVSGWPAKNRESIVLTSHYHSGNLQQPSLPSAPASGNDEDNDNNNDDNYGNNAAADDDDNYDDGLKSSSPYHHKKTTLITGMSAGLLSSCLSRDMACSAVLVQTASGVPDPEGAALLLQTISEMPHVPLELDVGPLLKEGREIKRRLAETIASLKRQEEAQATPYPAGRSMMYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MM18</accession>
    <name>A0A075MM18_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00206</name>
    </gene>
    <organism evidence="1 2">
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            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
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            <taxon>Nitrososphaera</taxon>
        </lineage>
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        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
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        <source>
            <dbReference type="EMBL" id="AIF82288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="103" mass="12259" checksum="2056FC81A68B7198" modified="2014-10-29" version="1">MMLLGREPRLYFIPTCSKISDDPVLGSITKLIEFFYIMITDTKMQKKRRPYLVLSPASPQHCTMSRDRTIGLRKYSHPKVCLLLQHLWMDDEVSKENDDRQWR</sequence>
</entry>
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        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="88" mass="10086" checksum="F3F826C59B1F7028" modified="2014-10-29" version="1">MKKERKIGRAPYFRPESTYNDFVIVLATSRATEYVMSAPPLKEKWREVRRTCPIVVHLRTNPLFLPPKIGHEIDGKSLGAAGEDFSNR</sequence>
</entry>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
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                <person name="Leonard M.T."/>
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                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR36503:SF2">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="VOC"/>
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    </dbReference>
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        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AIF82122.1"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <sequence length="135" mass="15626" checksum="0DF339992A93ACF1" modified="2014-10-29" version="1">MATKIFVNLPVKDLNKTVEFFTKLGFTFNPQFTDENATCMMVGEDIFVMLLVERFFKTFTKKEISDTTKNTEVIVALSAESREKVDQLMKKVIEAGGKEPRAPQDYGWMYGRAFEDINGHLWEIFYMDESAVKKE</sequence>
</entry>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <sequence length="67" mass="7625" checksum="900769AFF935BE3D" modified="2014-10-29" version="1">MITFRQNILIQISAVREASNIDARVAMLQTLNSSLPEGIRLRLPSMFTNAYVKRALETIEDKFIDSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MN02</accession>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
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                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">SR1</strain>
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        <location>
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF82202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="135" mass="15459" checksum="A3EBAE04E5D15B58" modified="2014-10-29" version="1">MFKEVATVFSHRRSLMKPRSMHAIIAEILRVCEQKTKRTHVIYKANLSHSMLQGYVELAWQSGLLDELPDRSLLITEKGREYLAHFTCAEKMLRINNNIDAVPSSPEEEEEEQQRQRPSVKAATAAASQVIDTYT</sequence>
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    <accession>A0A075MN20</accession>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
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                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">SR1</strain>
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    <dbReference type="GeneID" id="41596663"/>
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    <dbReference type="HOGENOM" id="CLU_1631705_0_0_2"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="163" mass="18220" checksum="4877D01B15D022CD" modified="2014-10-29" version="1">MSLTSAVAIALALVLALTVYAGQQARAESTNIAFSANFLDGLFEYKADIDAKQLFPTEGIKDDIVGKLQERDYKIPDIEREFVGFKINASDIKIYIKPSKIDSANTRLSVDVEGKNVKVDSKYLNKKYDKVDIDTIYGIYNTNTDKVTIHVPYATALALVFRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MN40</accession>
    <name>A0A075MN40_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00484</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699512.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MN40"/>
    <dbReference type="GeneID" id="41596357"/>
    <dbReference type="KEGG" id="nev:NTE_00484"/>
    <dbReference type="HOGENOM" id="CLU_2127716_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="113" mass="13269" checksum="DE2D18CF47ED1F94" modified="2014-10-29" version="1">MERKDLLPRSTLRSKSENQPRALGIDQVFGLGRRLEELDEKAEWCSRIASDLKGSSTSDYIVSALEYYRHERKSLTETPALAYAATNDTLEWCRRTRIRMTMTSRQRRYKLHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNH0</accession>
    <name>A0A075MNH0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Antitoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699352.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNH0"/>
    <dbReference type="STRING" id="1459636.NTE_00270"/>
    <dbReference type="GeneID" id="41596179"/>
    <dbReference type="KEGG" id="nev:NTE_00270"/>
    <dbReference type="eggNOG" id="arCOG08550">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_170073_1_1_2"/>
    <dbReference type="OrthoDB" id="9187at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003847">
        <property type="entry name" value="Put_antitoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02697">
        <property type="entry name" value="VAPB_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="75" mass="8813" checksum="B891178885354C8E" modified="2014-10-29" version="1">MISEKAYEVLKRRKRKNESFTDVILRLSSEKGSVANLLDLVREEDFEPISPETARHMKEASSEFRKNFQLRDAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNH1</accession>
    <name>A0A075MNH1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HD superfamily phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699931.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNH1"/>
    <dbReference type="STRING" id="1459636.NTE_01027"/>
    <dbReference type="GeneID" id="41596850"/>
    <dbReference type="KEGG" id="nev:NTE_01027"/>
    <dbReference type="eggNOG" id="arCOG04430">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026821_3_2_2"/>
    <dbReference type="OrthoDB" id="8895at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008832">
        <property type="term" value="F:dGTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006203">
        <property type="term" value="P:dGTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050135">
        <property type="entry name" value="dGTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045509">
        <property type="entry name" value="HD_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11373">
        <property type="entry name" value="DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11373:SF4">
        <property type="entry name" value="DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE SAMHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19276">
        <property type="entry name" value="HD_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD/PDEase" evidence="1">
        <location>
            <begin position="49"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="422" mass="47428" checksum="4514957F4F0DA16A" modified="2014-10-29" version="1">MDFAGEITDPIHRYIRFSQAEKDIIDSAAFQRLRRIRQLAGAHLVYPSAQHSRFEHSLGAMHIAGLACESLLGKGYIDNAEVVEELRLAALLHDIGHGPFSHLFEEVLETRCRTSHEEMGRLIITKSEIADALGKNGYSADHISRLSFGQSNVHFLNEIISGGLSADIMDYLPRDSYFTGAEYGKIDYHRLISSYEVASGRLAINRSALNSLESMLISRYEMFKAVYFHKTVRSAEVMLLHSMINADDALALTDTSLENYLSITDEATLERLCALDNGMAARLARDYRDRRLLKCVYEKLLHKRDRHKRMDRKALSALEVEIAQAAGVDRSHVFADASRASSMPLTPSKREMFSVLVTDKKGVREVPVSEIPLVDSIAGFFDMLRIYTTAESRQKVERSVKKVLGDQETMEMGAGRLHGSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNK2</accession>
    <name>A0A075MNK2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_00703</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699685.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNK2"/>
    <dbReference type="GeneID" id="41596558"/>
    <dbReference type="KEGG" id="nev:NTE_00703"/>
    <dbReference type="eggNOG" id="arCOG08035">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_862225_0_0_2"/>
    <dbReference type="OrthoDB" id="10016at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="234"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF82783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="324" mass="35276" checksum="61442B7C88252496" modified="2014-10-29" version="1">MMMTLIIAANFTAPAQAQTVVQAPRIIFLVNQDNFLPGDILIAYGKSFANDTIVIRIFDPAGKAVRIESIKADANGSFTEQIFLWPQPSKNFVFGRYMIEAASTIVPTYKESRTVSFSDIPSAGSPQFQSNILSIKLDSPTEISVGKTFRIFVQVTFDGALVNVDDPNQLLSSSHIHSGNDTINLFGKFVKLHEGIYYADVKLDKEGSYIIHAIAFHRGFLAHDSKVVSSGSSIGEIQESVNSLKAELDRTSHELNATRNDLTQSVNDARAAIKGDIEQAGSAVNQLSQASGQINSIILPILALISVIIALQISLFARIRASFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNT3</accession>
    <name>A0A075MNT3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699437.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNT3"/>
    <dbReference type="GeneID" id="41596273"/>
    <dbReference type="KEGG" id="nev:NTE_00390"/>
    <dbReference type="HOGENOM" id="CLU_1763786_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="147" mass="17059" checksum="50A5FC70D3DA83CF" modified="2014-10-29" version="1">MSSDSHSITLDAIEKALAIVGTESRNVILNYIQDRYGMDLNTLVRYRGEFTNYLEEMLGDSAEIVASRINKVLDRHQAKSTTLDLKHPLCYICNRTYASESMRRHLMMDHTREEVAHHLAVIYVDDWREEAELQVENNSTLHQLLHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNV1</accession>
    <name>A0A075MNV1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved protein implicated in secretion</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699452.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNV1"/>
    <dbReference type="STRING" id="1459636.NTE_00410"/>
    <dbReference type="GeneID" id="41596290"/>
    <dbReference type="KEGG" id="nev:NTE_00410"/>
    <dbReference type="eggNOG" id="arCOG00452">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095961_1_0_2"/>
    <dbReference type="OrthoDB" id="7724at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="216" mass="23328" checksum="42BD4BDE2E6F2EB1" modified="2014-10-29" version="1">MTGFDKNWSNQSKASASDKLKESLRPQGPLKPRIETAVNKLQLQTSKLDTMITKMNERDAALFRRVVDAMQRHDADTAKVLSNELAEVRKISKTLGNAKMAIEQVNMRLSTVHDLGDAMVALGPAMASIKGLKSGLTRFMPGADAEIGNMQNLLQGIMMDSLQGSGMGVELNAGSGGDIDQIMMEASAVAEQRVTDKFPSIPVGSTRVSVEGHQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNZ2</accession>
    <name>A0A075MNZ2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699480.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNZ2"/>
    <dbReference type="STRING" id="1459636.NTE_00445"/>
    <dbReference type="GeneID" id="41596321"/>
    <dbReference type="KEGG" id="nev:NTE_00445"/>
    <dbReference type="HOGENOM" id="CLU_1242980_0_0_2"/>
    <dbReference type="OrthoDB" id="7547at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="222" mass="24933" checksum="7D9EF9F6B71D2620" modified="2014-10-29" version="1">MVVEEVRYDFADYPKYADDFVRDLVKLMIMSKMNSTARNTSSKAYFQKLVSQMEGCEANVVKYGQPLLYVKYRGVQFTDQKVTSQFVRTKGHVIDVTMESVFGEFVKTFDSLASMSESKVKWGLAGADEKEKPEPMFALLDKFVDAVGRLTALDPASPNSLAEKRFGIRNASVARKSLHLEFLIDGRLHIVELNPSKRKEKAVELLFGASEAAKAIVALIMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNZ3</accession>
    <name>A0A075MNZ3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">N5-carboxyaminoimidazole ribonucleotide mutase</fullName>
            <shortName evidence="3 4">N5-CAIR mutase</shortName>
            <ecNumber evidence="3 4">5.4.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">5-(carboxyamino)imidazole ribonucleotide mutase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">purE</name>
        <name evidence="6" type="ORF">NTE_00792</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + H(+) = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate</text>
            <dbReference type="Rhea" id="RHEA:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58730"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="EC" id="5.4.99.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AIR carboxylase family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.18" evidence="3 4"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNZ3"/>
    <dbReference type="STRING" id="1459636.NTE_00792"/>
    <dbReference type="KEGG" id="nev:NTE_00792"/>
    <dbReference type="eggNOG" id="arCOG02464">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094982_2_0_2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00943"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034023">
        <property type="term" value="F:5-(carboxyamino)imidazole ribonucleotide mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01929">
        <property type="entry name" value="PurE_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033747">
        <property type="entry name" value="PurE_ClassI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000031">
        <property type="entry name" value="PurE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024694">
        <property type="entry name" value="PurE_prokaryotes"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01162">
        <property type="entry name" value="purE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23046:SF2">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23046">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00731">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001338">
        <property type="entry name" value="AIR_carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01001">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52255">
        <property type="entry name" value="N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1 3 4" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PurE" evidence="5">
        <location>
            <begin position="9"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR001338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF82870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="171" mass="18529" checksum="09E61B4CAE1DD877" modified="2014-10-29" version="1">MYMMHEKRPLVSVVSPLPRLLEQVKDAAVALDSFGIKSEARIVAAHRSPHKTIRFVAECHARGIEVIIATGEGSAHLPGMIASLTTIPVIGVPLKGDASPGGMDSFLSMAQMPRGVPVGTMGINAAYNAGIFACQILALKYPELQEKLKRYKEMMEEQVESEDAKQSKVIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPD7</accession>
    <name>A0A075MPD7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ERCC4-type nuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NTE_01348</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700190.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPD7"/>
    <dbReference type="STRING" id="1459636.NTE_01348"/>
    <dbReference type="GeneID" id="41597146"/>
    <dbReference type="KEGG" id="nev:NTE_01348"/>
    <dbReference type="eggNOG" id="arCOG04206">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101253_0_0_2"/>
    <dbReference type="OrthoDB" id="121419at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901255">
        <property type="term" value="P:nucleotide-excision repair involved in interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20075">
        <property type="entry name" value="XPF_nuclease_XPF_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006166">
        <property type="entry name" value="ERCC4_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10150">
        <property type="entry name" value="DNA REPAIR ENDONUCLEASE XPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10150:SF0">
        <property type="entry name" value="DNA REPAIR ENDONUCLEASE XPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02732">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14520">
        <property type="entry name" value="HHH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00891">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC4" evidence="8">
        <location>
            <begin position="4"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Helix-hairpin-helix DNA-binding motif class 1" evidence="7">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Helix-hairpin-helix DNA-binding motif class 1" evidence="7">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF83416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="243" mass="26749" checksum="F07CB835735F169D" modified="2014-10-29" version="1">MPARIVVDERERPSGIPDILRKSGVVVDFAQLVVGDYIVSPDTAVERKTVHDLVHSIYDGRLYVQCAQLVKHYQKPIVIIQGDLTRLAEIPDNIEDEEKKKKMAERLPLAFDALATVAMEFRIPVLHAPDAEHAAVLLGTLAAKGLQNGITSGPLLKKIRKENPVYLQQLYVLSSVPGVGDKLAARMLEKFKTPQRALNASAAELATIPGFGLARAQRLRKILDSAAKTDSVIQKTLFESNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPH4</accession>
    <name>A0A075MPH4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01389</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700226.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPH4"/>
    <dbReference type="STRING" id="1459636.NTE_01389"/>
    <dbReference type="GeneID" id="41597185"/>
    <dbReference type="KEGG" id="nev:NTE_01389"/>
    <dbReference type="HOGENOM" id="CLU_2067886_0_0_2"/>
    <dbReference type="OrthoDB" id="10727at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="106" mass="11933" checksum="A26968F89941C5EF" modified="2014-10-29" version="1">MQEDMWLEVRACQGTPAAKDLEHETVLRIPALSEALKAVEKASLDMARKGGSTMWDYSRKLEPGEADDVRGLFAGAQEKDDGRSRSLSTDYSYYGRCYTLTLFTFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPU1</accession>
    <name>A0A075MPU1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hemerythrin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01518</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700326.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPU1"/>
    <dbReference type="STRING" id="1459636.NTE_01518"/>
    <dbReference type="GeneID" id="41597305"/>
    <dbReference type="KEGG" id="nev:NTE_01518"/>
    <dbReference type="eggNOG" id="arCOG01471">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095978_2_0_2"/>
    <dbReference type="OrthoDB" id="131831at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.520">
        <property type="entry name" value="nmb1532 protein domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39966">
        <property type="entry name" value="BLL2471 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39966:SF1">
        <property type="entry name" value="HEMERYTHRIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin-like" evidence="1">
        <location>
            <begin position="5"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="187" mass="21027" checksum="8A3EBA2C081E02D0" modified="2014-10-29" version="1">MSSSTESLRNDHFLIEKMMRALNVTADLLQAGKSIPAPFLEQALDFTKNFTNVCHHGKEEDTLFPTLERGGMPRQGGPIARMLLEHEMTKQLAEKMDVSAKAYVQTGNAGQLVADIRSYTDHVSQHLTKENFRLFAMADMMLQGKAAQVNQELAKTEEAKLQSLGKTRSHYEQLVKSYDAEIRKNQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQE7</accession>
    <name>A0A075MQE7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NTE_01365</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQE7"/>
    <dbReference type="KEGG" id="nev:NTE_01365"/>
    <dbReference type="eggNOG" id="arCOG15271">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_459023_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004868">
        <property type="entry name" value="DNA-dir_DNA_pol_B_mt/vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03175">
        <property type="entry name" value="DNA_pol_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B mitochondria/virus" evidence="9">
        <location>
            <begin position="180"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIF83433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="594" mass="68646" checksum="3F458021BF2C9438" modified="2014-10-29" version="1">MTDYKDLSKIDTTVAQHRKATDAGIRPVYGLDTETYQGDIFLIADSDGRYLDKDVSADTVLDFLFHKKYQNAVNVFYNLKFDAIVILKLLGKELERYLHTRELAFQHGDFRIKYIPKKCLTITKGHKSVSFYDIAQFFKTSLQQAYERNIGPMPEHFKGLKSARGEFSARFRRRHIRLLREYCINDCIMTKALGEKWLELYYQAAGFYPKRLLSSAYLASRAMIFRGIAFPRFAEVPLHTQVLAYRAFVGGRFEQTKRGVIGEARNYDINSAYPDKIAKLHDLTDGQWMQGNAIESGATMGFFKVVANVPDWKYLGPFPFKANANLVYPTGKFVTYVSIEELKACERKEWYEILDSWQFVPNDPNYHPYDEFVREYYAKKTELKERNDPLHIPFKEMLNSIYGKTAETMQLEKKRVMGTFFNPVIASHITGSTRAQIYRYIRNNGIEKDVAFIATDGISVTRDLGKGSKALGKFALKDYAQDVFCIQNGINRWNGNWKERGIGSEKGKTLDNYDIYQSGEGVYMKLKVERVTNLRSAIRQGKIAQIGVFKEEIRKVDFDGDRKRFWLGKINSLNEDQFNESSPLSLSVFTREQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQE8</accession>
    <name>A0A075MQE8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Small GTP-binding protein domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_01695</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700468.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQE8"/>
    <dbReference type="STRING" id="1459636.NTE_01695"/>
    <dbReference type="GeneID" id="41597465"/>
    <dbReference type="KEGG" id="nev:NTE_01695"/>
    <dbReference type="eggNOG" id="arCOG00358">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044997_0_0_2"/>
    <dbReference type="OrthoDB" id="372125at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01896">
        <property type="entry name" value="DRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01666">
        <property type="entry name" value="TGS_DRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000003">
        <property type="entry name" value="Developmentally-regulated GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045001">
        <property type="entry name" value="DRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031662">
        <property type="entry name" value="GTP-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006074">
        <property type="entry name" value="GTP1-OBG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43127">
        <property type="entry name" value="DEVELOPMENTALLY-REGULATED GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16897">
        <property type="entry name" value="MMR_HSR1_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00905">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="3">
        <location>
            <begin position="67"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="4">
        <location>
            <begin position="293"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF83756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="373" mass="41160" checksum="1A6DE991A81E83A4" modified="2014-10-29" version="1">MGIPEKIKAIQDEIHKTQINKATEFHVGLLKAKIAKLKREQEQNIHGRTVHTGGENAGFDVRKAGDATVVLIGLPSVGKSTLLNRLTNAKSRVASYQFTTLTAIPGMMDYRGAKIQVLDLPGIIEGAAAGKGFGRRVISVARGADLVLLILDVFQPQHIGLLKRELAEAGIKLDERPPDVVIEKTSTGGLSINCQVPIKMEERMVKEIARVYGIHNGRIIIREPGLTDDQLIDVLSENRVYTKSLVLLNKIDLVNQGFIKEVQSQIGNNFIPVSADANVNIDAVKEAIYNKLDFIRIYMRPKGGETDYKEPMIVQNGSTVQDICNKIHRSMTRNFKYGMVWGKSAKFAGQKVGLDHVMYDEDVLTIVKNPGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQM4</accession>
    <name>A0A075MQM4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01775</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700536.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQM4"/>
    <dbReference type="STRING" id="1459636.NTE_01775"/>
    <dbReference type="GeneID" id="41597543"/>
    <dbReference type="KEGG" id="nev:NTE_01775"/>
    <dbReference type="HOGENOM" id="CLU_2366065_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="95" mass="11206" checksum="5CAAA38828662638" modified="2014-10-29" version="1">MSSQAPDSPQKIDYNRKRSEYTNYARLQHWSIDHPNYRITRVQQIVEVEVWAHPECSKECREVIEGIFGYRLKLLHSKDLGLTVRFVFEILGGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQT1</accession>
    <name>A0A075MQT1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">precorrin-2 dehydrogenase</fullName>
            <ecNumber evidence="2">1.3.1.76</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NTE_01383</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>precorrin-2 + NAD(+) = sirohydrochlorin + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15613"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58351"/>
            <dbReference type="ChEBI" id="CHEBI:58827"/>
            <dbReference type="EC" id="1.3.1.76"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; siroheme biosynthesis; sirohydrochlorin from precorrin-2: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.76" evidence="2"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385177.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQT1"/>
    <dbReference type="STRING" id="1459636.NTE_01383"/>
    <dbReference type="GeneID" id="41597179"/>
    <dbReference type="KEGG" id="nev:NTE_01383"/>
    <dbReference type="eggNOG" id="arCOG01044">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011276_8_2_2"/>
    <dbReference type="OrthoDB" id="10510at2157"/>
    <dbReference type="UniPathway" id="UPA00262">
        <property type="reaction ID" value="UER00222"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043115">
        <property type="term" value="F:precorrin-2 dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.110">
        <property type="entry name" value="Siroheme synthase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028161">
        <property type="entry name" value="Met8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028281">
        <property type="entry name" value="Sirohaem_synthase_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006367">
        <property type="entry name" value="Sirohaem_synthase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01470">
        <property type="entry name" value="cysG_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35330">
        <property type="entry name" value="SIROHEME BIOSYNTHESIS PROTEIN MET8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35330:SF1">
        <property type="entry name" value="SIROHEME BIOSYNTHESIS PROTEIN MET8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13241">
        <property type="entry name" value="NAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14824">
        <property type="entry name" value="Sirohm_synth_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75615">
        <property type="entry name" value="Siroheme synthase middle domains-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Siroheme synthase central" evidence="7">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF83450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="222" mass="25150" checksum="00C3AE2498BDCFFC" modified="2014-10-29" version="1">MIVDLNLKDKHAIVIGGGTEGVRKVNALLGQGCRITVISNRFNKYLRDQEKAGKIETVKATLKDASILDGYDSPFLVLASTDDRELNRKLCQKGREKGAFVYSVDDPPYSDFSYASVINIEGVMQVAISTSGKSPIMARQVRIRAERILRRVIKKSDIENARLQEFARNAAKPKLKTVEQRKEFLYSILYDRRIQNLIKEDKMEGAKSATLELLQEWVKKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQT8</accession>
    <name>A0A075MQT8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cache domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NTE_01510</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQT8"/>
    <dbReference type="STRING" id="1459636.NTE_01510"/>
    <dbReference type="KEGG" id="nev:NTE_01510"/>
    <dbReference type="eggNOG" id="arCOG02362">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_996115_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033479">
        <property type="entry name" value="dCache_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029151">
        <property type="entry name" value="Sensor-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02743">
        <property type="entry name" value="dCache_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103190">
        <property type="entry name" value="Sensory domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Cache" evidence="7">
        <location>
            <begin position="50"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF83573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="299" mass="32039" checksum="4C8558739ED29A74" modified="2014-10-29" version="1">MLIGYSLQRIVVIAAAVIVAAAIVAAAGIIVAYPLQAANPKPVDRSPDLRLLASNLEERIAGYVKVMELTGMMPEVRSTDSLSLVSTAQMGIPQDADVAKRQVAKNIIATYGDDNVASIFFLTPEGNIYIGEPFEQQKQLPRLNYSDRDWYQGVSSTKEAYVSSVFMSAAIHEPAVAVAVPVYGQTAAGAEEKDNNIIGYWVAIINLDGIEKGLKQLEGSSRIIFVDHNGTEIADSARDPSAARTDLRSFSNLESVKAALAGKSGSIVEVIDGKSMRVSYAPVKAQPHTWAVVSMQPEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQU1</accession>
    <name>A0A075MQU1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NTE_01851</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQU1"/>
    <dbReference type="STRING" id="1459636.NTE_01851"/>
    <dbReference type="KEGG" id="nev:NTE_01851"/>
    <dbReference type="eggNOG" id="arCOG02050">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045498_5_4_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051598">
        <property type="entry name" value="TSUP/Inactive_protease-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43701">
        <property type="entry name" value="MEMBRANE TRANSPORTER PROTEIN MJ0441-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43701:SF2">
        <property type="entry name" value="MEMBRANE TRANSPORTER PROTEIN YJNA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF83911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="259" mass="26856" checksum="04988ABB15B815E6" modified="2014-10-29" version="1">MLFDIVTTVIVLVAVGLGAGTLGSMLGVGGGIIMGPALTFMGLPPSQTAATSLFAVTSTSVSSTVAFSRQKRIDYRHGLELAAGAVPGAVLGGLISSTISEADFKLYFGILLMAVGTYIVFRSSILKEKEARKISIAQHAAIFAITFGAGIISSLFGVGGGVIFVPVMLLIHRMTIHRATATSQLTLMITSFAGIFTHALLGHPNYVYAVALSAGAVVGAQLGARWSKNAKAASLQKMLGIMLVAVAITFILEWLGVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQW8</accession>
    <name>A0A075MQW8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700255.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQW8"/>
    <dbReference type="STRING" id="1459636.NTE_01431"/>
    <dbReference type="GeneID" id="41597226"/>
    <dbReference type="KEGG" id="nev:NTE_01431"/>
    <dbReference type="HOGENOM" id="CLU_2875216_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="68" mass="6724" checksum="CF63535C3D8912FA" modified="2014-10-29" version="1">MQKGLMIALIAAGIVITAAVAIAGVAAFAPGQQGNNNNNNAPPPTAASTGKNLTLNLNENLGLKGNAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQW9</accession>
    <name>A0A075MQW9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_01887</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700620.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQW9"/>
    <dbReference type="GeneID" id="41597641"/>
    <dbReference type="KEGG" id="nev:NTE_01887"/>
    <dbReference type="HOGENOM" id="CLU_270823_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="913"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1037"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1076"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1179"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="693"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="913"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1045"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1076"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1116"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1184"/>
            <end position="1200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF83946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="1200" mass="127729" checksum="13FAD3A8E8150AA7" modified="2014-10-29" version="1">MTSMEDNYKKYQLANAELQKKAIQTGQSQTLTSADLAAQASAPAANTGGVSAEAERTLATQTFLEAQRRAQEQALSSGQTQNLSDFLPEARQAVEDRYTVAITPGFGKLGGGSRYEEGPKRTMSIPIYDKAAENKALEKNYAAYQSQNLAAQRQSLAQSGQNGASQRVNVSRLALGDHILQFVREQEKGGKVKYAGQVEMSPTGDISPLFVDVAESKKFYAEFMGAQRENTAARKANEKAEADYNAWISGMQAKGFGGLVETKDSSGKTTAKFTTFTSGGKTVAVRDDGTFEIPDPYKDAKLNLDAAEQVWRFGVEGFGAAGAGLVSLGGNLISKAEDALGFKAQAERTRNNSAAASQAIKSATDLGAFSTLTESIGRTFGSDTFYAESSKAAQDKKIIDAQNIPVGSIVGLGAAYGVKELEKSGMKQSVESATGLSFGSGDEAIAQQYKALQERPVEFIGGTIADIATFGNPVKIVKDVSKVASGLKLTRSVEKEAQAAAKRAGVEGDVSVRPIEQRKIPATGEVVDVPLQPTRFANVAVASRNVKIPLVGGKKIDLGIMQNETPIASINIPESISVKKLTINPTREVVTQEGTPIGIISPRSNTAIIQNPSPLPLAAKADLVGQDLKSVTSVQNTAEWLKNQTKAPSAEEIKAQGVNPYFHSPKVQEMIENYAFKNDPTLNMKSQKLSKKLEPLYSKADDLRDQKERLQSQVVDIDNQISTASKSNPADMFGINSGDAASSKELADLTSQKSDLLQKIAGIEEKITGVQSEISSTTTTFGIKRADALGALQHASEFFYKVGGKGRINPAKGGAPADVMFPKVQNAPKSSNLIASSTTDVYNLEQNPALPSARLSRLAGYDLARDSEGLDPLSGNYFITKGGKAIKLMKEQVATDVEFDLNKVSKFVKEDTKRSKAVSDEARTKKPSTPFKFDVEPARTPSAELPKTNGGKLIEVSSAKEAPSFASVKNTIFDAEQSAKQAGRSLGLGGNAAGYANAGLLGFKGATGVERVNKKRTVTNETTEYVRYPGESLGLKSRESRRTESLVNPGSLTETSNPFNIKPQRGGLDVANPFSHGTGSRSGAKTDIFTTPRNITSTGSRLDQGTITDLNFRLDTTTGRPPRSPPTSRKVPPIAIPTFMPGGVAASQGSKGAGVSSFKQRGVRNILFGAGAFDIQEGGQKQVKAGKSKGKKKGLWKGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQX6</accession>
    <name>A0A075MQX6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative RNA-binding protein (Contains PUA domain)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01897</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700626.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQX6"/>
    <dbReference type="STRING" id="1459636.NTE_01897"/>
    <dbReference type="GeneID" id="41597647"/>
    <dbReference type="KEGG" id="nev:NTE_01897"/>
    <dbReference type="eggNOG" id="arCOG00985">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090468_1_1_2"/>
    <dbReference type="OrthoDB" id="27972at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21154">
        <property type="entry name" value="PUA_MJ1432-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.400.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016437">
        <property type="entry name" value="MCT-1/Tma20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22798:SF0">
        <property type="entry name" value="MALIGNANT T-CELL-AMPLIFIED SEQUENCE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22798">
        <property type="entry name" value="MCT-1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PUA" evidence="1">
        <location>
            <begin position="62"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="146" mass="16141" checksum="2ADB36CB188920F8" modified="2014-10-29" version="1">MKALWPAGTVPKVKTFKVYEVDESKHLLVSDDEITCVRVKDDDNIIIIPFLGGKPETLAQFPSVKVDMGAVKFVCNGAKVLRPGIVEFGSFKKGDIVTVQDQTHGKMLAVGIALEDSEAAKAMQKGYVIDNLHYISDKIWEAYKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQY4</accession>
    <name>A0A075MQY4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Anthranilate phosphoribosyltransferase</fullName>
            <ecNumber evidence="2 8">2.4.2.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">trpD</name>
        <name evidence="11" type="ORF">NTE_01907</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N-(5-phospho-beta-D-ribosyl)anthranilate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + anthranilate</text>
            <dbReference type="Rhea" id="RHEA:11768"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:18277"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 2 magnesium ions per monomer.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the anthranilate phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.18" evidence="2 8"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700634.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQY4"/>
    <dbReference type="STRING" id="1459636.NTE_01907"/>
    <dbReference type="GeneID" id="41597657"/>
    <dbReference type="KEGG" id="nev:NTE_01907"/>
    <dbReference type="eggNOG" id="arCOG02012">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034315_2_1_2"/>
    <dbReference type="OrthoDB" id="8214at2157"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00041"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004048">
        <property type="term" value="F:anthranilate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1030.10:FF:000002">
        <property type="entry name" value="Anthranilate phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1030.10">
        <property type="entry name" value="Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.970.10">
        <property type="entry name" value="Transferase, Pyrimidine Nucleoside Phosphorylase, Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00211">
        <property type="entry name" value="TrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005940">
        <property type="entry name" value="Anthranilate_Pribosyl_Tfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000312">
        <property type="entry name" value="Glycosyl_Trfase_fam3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017459">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036320">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035902">
        <property type="entry name" value="Nuc_phospho_transferase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01245">
        <property type="entry name" value="trpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43285">
        <property type="entry name" value="ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43285:SF2">
        <property type="entry name" value="ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02885">
        <property type="entry name" value="Glycos_trans_3N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00591">
        <property type="entry name" value="Glycos_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52418">
        <property type="entry name" value="Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47648">
        <property type="entry name" value="Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="4 8 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 8" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Glycosyl transferase family 3 N-terminal" evidence="10">
        <location>
            <begin position="10"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 3" evidence="9">
        <location>
            <begin position="81"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>anthranilate</name>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="90"/>
            <end position="91"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="97"/>
            <end position="100"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="115"/>
            <end position="123"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>anthranilate</name>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>anthranilate</name>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIF83966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="360" mass="37750" checksum="1156BCCFABAE8CD8" modified="2014-10-29" version="1">MSTAQADLRPAIRKLVARTELSEAEMADALDSILAGEASEASIASFLVALAMKGETPAELRAILKTIRRHATRITPAVGGPLIDTCGTGGDSIRTFNVSTAAAVVAAAAGAKVAKHGNRSVSGVCGSADFLESIGLDLNAPPAKVQKCMEDTGIGFLFAPAFHPAMKNVAPARKTVGIRTVFNVVGPLSNPCTNISGQVIGVFEPFFMETLAEACKGYINEAMIVHAADGFDELSNTCENDILWVTGDGQTTKRLRLSPKVVGMAVARPEQLVVTTKDESIKSTLAVIYGNGPQEKEDMVVLNASAALVVGKVASDLKEGVEIARGAIKSGQAQKKLARLVSECGNKEALEQAEKKYLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MR24</accession>
    <name>A0A075MR24_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CAAX protease self-immunity</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01943</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700659.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MR24"/>
    <dbReference type="GeneID" id="41597691"/>
    <dbReference type="KEGG" id="nev:NTE_01943"/>
    <dbReference type="HOGENOM" id="CLU_1507320_0_0_2"/>
    <dbReference type="OrthoDB" id="8703at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="178" mass="20404" checksum="AF14F0218FFB80BF" modified="2014-10-29" version="1">MDSTFLIIFYVATVVPTLLLVKETKPRLKNLRNGLRSIVYLPLTVGILMLYVIFAMDFFSKIPILNWSWLGYNIAIGPAADQGLWGVLPFVPMLVYMLIHVNYFEEMYFRKTALLTVVWAFLHIAMGVAVHVALALLPLGFFYKYLYKKRGLDHAYALHFATNIIIVAVSIASYFVRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRI9</accession>
    <name>A0A075MRI9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methylase involved in ubiquinone/menaquinone biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01712</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700482.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRI9"/>
    <dbReference type="STRING" id="1459636.NTE_01712"/>
    <dbReference type="GeneID" id="41597481"/>
    <dbReference type="KEGG" id="nev:NTE_01712"/>
    <dbReference type="eggNOG" id="arCOG01783">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_807987_0_0_2"/>
    <dbReference type="OrthoDB" id="1018at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053173">
        <property type="entry name" value="SAM-binding_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45128">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45128:SF1">
        <property type="entry name" value="S-ADENOSYLMETHIONINE-DEPENDENT METHYLTRANSFERASE RV2258C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="172"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="343" mass="37888" checksum="ED340F83EB4BF7EB" modified="2014-10-29" version="1">MPAAWKTRSAEFKKLWGYSVGLYGVWVAHVGRRTGLFEAIAKSPATFEELAAQTSFNPDAVKAWCSAALALGFLRMKGKKLYLPAKTKEILLDKKSPDYLGGQFSYIALRSLEYGGLEDLIRTGRKRETTSLTFEAIVEATDWDHNAFLSAIKNRGGKSHKLHTMLVRGCRVLDVGCGTGTFIEKLLQHYPRSSFVGVEPSEVAAHKAMEMAAGKPAIEVLRETGEAMNFESEFDLVYLGESLYAASDKQAIVSNCYRALKKGGVIAIVEGLLPDDDDNDHKTSSNDDDENRLIMGMQVDFSLQGYRFMTRNEIGTLLKTAGFSKTAFEDFGGSLYLVTAWKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRJ3</accession>
    <name>A0A075MRJ3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01717</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRJ3"/>
    <dbReference type="STRING" id="1459636.NTE_01717"/>
    <dbReference type="KEGG" id="nev:NTE_01717"/>
    <dbReference type="eggNOG" id="arCOG08639">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1375469_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="198" mass="23707" checksum="DAB76E51E61F8FD2" modified="2014-10-29" version="1">MALKAEKLFFIYVARNDEWVRLQSEDWGYVSAMARFFKWWIRRYYDFEIAVEADILPVIPGKLFDRMSLALFLRDHESRGQDIYHFYLAPFKPFFTDCKTEGYTTDNFGLAFWNRPKEGSEAKRNAMFAEENCPRISHVLSHEILRMQGRKKKEYFENVHDLWRQHKEKGKPFLYYDSQFKRTTSDGCKYSTIDATGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRS3</accession>
    <name>A0A075MRS3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_01729</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700494.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRS3"/>
    <dbReference type="STRING" id="1459636.NTE_01729"/>
    <dbReference type="GeneID" id="41597498"/>
    <dbReference type="KEGG" id="nev:NTE_01729"/>
    <dbReference type="eggNOG" id="arCOG01585">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1763930_0_0_2"/>
    <dbReference type="OrthoDB" id="33200at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043200">
        <property type="term" value="P:response to amino acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013603">
        <property type="entry name" value="TRASH_TR_C_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30154">
        <property type="entry name" value="LEUCINE-RESPONSIVE REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30154:SF34">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR AZLB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08394">
        <property type="entry name" value="Arc_trans_TRASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="5"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF83790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="147" mass="17034" checksum="3F9307E19112A55A" modified="2014-10-29" version="1">MPVQLDDTDVAILKSLMEDGRKSFRAISREIKVSTPTVKARYERLVNIGLIKAVRPEIDMSKIDKKSDEIGDALQELKKQKKHFHVYVEGLKVKLKCDFCGGPVHDKPKVLRFARFERFFCCVQCRASYKEKYGGRIEALKRNQEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRT7</accession>
    <name>A0A075MRT7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein uS14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rps14</name>
        <name evidence="8" type="ORF">NTE_01823</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds 16S rRNA, required for the assembly of 30S particles.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_075053861.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRT7"/>
    <dbReference type="STRING" id="1459636.NTE_01823"/>
    <dbReference type="GeneID" id="41597588"/>
    <dbReference type="KEGG" id="nev:NTE_01823"/>
    <dbReference type="eggNOG" id="arCOG00782">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_177289_2_2_2"/>
    <dbReference type="OrthoDB" id="5615at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.830.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.10">
        <property type="entry name" value="30s Ribosomal Protein S14, Chain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01364_A">
        <property type="entry name" value="Ribosomal_uS14_2_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_uS14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023676">
        <property type="entry name" value="Ribosomal_uS14_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018271">
        <property type="entry name" value="Ribosomal_uS14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039744">
        <property type="entry name" value="RIbosomal_uS14_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043140">
        <property type="entry name" value="Ribosomal_uS14_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004424">
        <property type="entry name" value="PRK05766.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12010">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12010:SF2">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00527">
        <property type="entry name" value="RIBOSOMAL_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF83883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="59" mass="6970" checksum="BFC6A2EE04F65845" modified="2014-10-29" version="1">MPKPREYATTGRKQLAHGRGVRWCKRCGSYNGLIRKYNLMLCRQCFREVAESLGFKKFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRU0</accession>
    <name>A0A075MRU0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Transcription initiation factor IIB</fullName>
            <shortName evidence="7">TFIIB</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tfb</name>
        <name evidence="10" type="ORF">NTE_01473</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the TFIIB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_075055910.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRU0"/>
    <dbReference type="STRING" id="1459636.NTE_01473"/>
    <dbReference type="GeneID" id="41597266"/>
    <dbReference type="KEGG" id="nev:NTE_01473"/>
    <dbReference type="eggNOG" id="arCOG01981">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043736_0_1_2"/>
    <dbReference type="OrthoDB" id="7429at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20550">
        <property type="entry name" value="CYCLIN_TFIIB_archaea_like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000023">
        <property type="entry name" value="Transcription initiation factor IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.170:FF:000001">
        <property type="entry name" value="Transcription initiation factor IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00383">
        <property type="entry name" value="TF2B_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023484">
        <property type="entry name" value="TFIIB_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023486">
        <property type="entry name" value="TFIIB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001658">
        <property type="entry name" value="PRK00423.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618:SF13">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="Zn_Ribbon_TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00782">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51134">
        <property type="entry name" value="ZF_TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIB-type" evidence="9">
        <location>
            <begin position="2"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="repeat" description="1" evidence="7">
        <location>
            <begin position="119"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="repeat" description="2" evidence="7">
        <location>
            <begin position="213"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="6"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00053882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIF83537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="298" mass="32718" checksum="7488C0C8A1DB3E77" modified="2014-10-29" version="1">MFGDRCPRCGRGSMVTDNSSGELFCGNCGFVVSERIEEMGPEWRAFSKEEHEDRSRAGIPTSLAMHDMGLATIIGPVDKDASGKPLSASMKSTIERLRTWDSRSQVHEPVDRNFRQAFSELDRLKDKLAVGDAVIEKAAYVYRKALEKGLVRGRSISALVAAALYAACRDTETPRTLKDIANASNIKKKDVARCYRLLIRELDLKMPVVDPVKCVARIASKAGLSEKTKRKALEILKKAEEGKISAGKDPMGLAAAALYVACVMNGENKTQKDVAEAAGVTEVTIRNRYKGLKTHLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRX9</accession>
    <name>A0A075MRX9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Geranylgeranylglyceryl phosphate synthase</fullName>
            <shortName evidence="9">GGGP synthase</shortName>
            <shortName evidence="9">GGGPS</shortName>
            <ecNumber evidence="9">2.5.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">(S)-3-O-geranylgeranylglyceryl phosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Phosphoglycerol geranylgeranyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NTE_00080</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>sn-glycerol 1-phosphate + (2E,6E,10E)-geranylgeranyl diphosphate = sn-3-O-(geranylgeranyl)glycerol 1-phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23404"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57677"/>
            <dbReference type="ChEBI" id="CHEBI:57685"/>
            <dbReference type="ChEBI" id="CHEBI:58756"/>
            <dbReference type="EC" id="2.5.1.41"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="9">Membrane lipid metabolism; glycerophospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the GGGP/HepGP synthase family. Group II subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.41" evidence="9"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987083.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRX9"/>
    <dbReference type="STRING" id="1459636.NTE_00080"/>
    <dbReference type="GeneID" id="41596028"/>
    <dbReference type="KEGG" id="nev:NTE_00080"/>
    <dbReference type="eggNOG" id="arCOG01085">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068610_0_0_2"/>
    <dbReference type="UniPathway" id="UPA00940"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:imidazoleglycerol-phosphate synthase activity"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047294">
        <property type="term" value="F:phosphoglycerol geranylgeranyltransferase activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02812">
        <property type="entry name" value="PcrB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.390:FF:000001">
        <property type="entry name" value="Heptaprenylglyceryl phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.390">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00112">
        <property type="entry name" value="GGGP_HepGP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038597">
        <property type="entry name" value="GGGP/HepGP_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008205">
        <property type="entry name" value="GGGP_HepGP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010946">
        <property type="entry name" value="GGGP_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050064">
        <property type="entry name" value="IGPS_HisA/HisF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01769">
        <property type="entry name" value="GGGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01768">
        <property type="entry name" value="GGGP-family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003198">
        <property type="entry name" value="PRK04169.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21235:SF22">
        <property type="entry name" value="GERANYLGERANYLGLYCERYL PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21235">
        <property type="entry name" value="IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE SUBUNIT HISF/H IGP SYNTHASE SUBUNIT HISF/H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01884">
        <property type="entry name" value="PcrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 9" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5 9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9 10" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="180"/>
            <end position="186"/>
        </location>
        <ligand>
            <name>sn-glycerol 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57685"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="211"/>
            <end position="212"/>
        </location>
        <ligand>
            <name>sn-glycerol 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57685"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="233"/>
            <end position="234"/>
        </location>
        <ligand>
            <name>sn-glycerol 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57685"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIF82164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="257" mass="26933" checksum="66028EC91817DE4D" modified="2014-10-29" version="1">MVAAVPAVGKVETYLREEIKKHGTICFPLIDSENSTNNDVVTSIARKVEAAGASAVLVGGSSATDQMELAKVVSDIKGAVKIPVILFPGNVTGVSPKADAILFSSLLNSEDPYFITGAQALGALAVKKHGIEPLPTAYVIVGEGTAAWFVGRARGIPSHKPNLAVMYSLAAQYMGMRFVYLEAGSGASQNVTPEMVAAVRKYYEGILIVGGGIKTPETAGQIAKAGADVIVVGTMIEKDGDWQQKLSSMVKAMRQAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MS10</accession>
    <name>A0A075MS10_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl29</name>
        <name evidence="5" type="ORF">NTE_01830</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="WP_193354064.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
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    <dbReference type="AlphaFoldDB" id="A0A075MS10"/>
    <dbReference type="STRING" id="1459636.NTE_01830"/>
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    <dbReference type="KEGG" id="nev:NTE_01830"/>
    <dbReference type="eggNOG" id="arCOG00785">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_158491_2_2_2"/>
    <dbReference type="OrthoDB" id="11736at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00374">
        <property type="entry name" value="Ribosomal_uL29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_uL29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_uL29_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00012">
        <property type="entry name" value="L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00831">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="Ribosomal protein L29 (L29p)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF83890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="68" mass="7913" checksum="01A5FC2AF6EBE02C" modified="2014-10-29" version="1">MARLKLKTLREMNDTDLSQKLAEMKADLAKVRSEQTKGTLKKHSGEIRYMRRDIARILTLLNERKAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MS32</accession>
    <name>A0A075MS32_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">indole-3-glycerol-phosphate synthase</fullName>
            <ecNumber evidence="3">4.1.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NTE_01914</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:23476"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="EC" id="4.1.1.48"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.48" evidence="3"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700640.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MS32"/>
    <dbReference type="STRING" id="1459636.NTE_01914"/>
    <dbReference type="GeneID" id="41597663"/>
    <dbReference type="KEGG" id="nev:NTE_01914"/>
    <dbReference type="eggNOG" id="arCOG01088">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034247_0_1_2"/>
    <dbReference type="OrthoDB" id="15223at2157"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00043"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004425">
        <property type="term" value="F:indole-3-glycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004640">
        <property type="term" value="F:phosphoribosylanthranilate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00331">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045186">
        <property type="entry name" value="Indole-3-glycerol_P_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013798">
        <property type="entry name" value="Indole-3-glycerol_P_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22854:SF2">
        <property type="entry name" value="INDOLE-3-GLYCEROL-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22854">
        <property type="entry name" value="TRYPTOPHAN BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00218">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Indole-3-glycerol phosphate synthase" evidence="9">
        <location>
            <begin position="35"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIF83973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="267" mass="29125" checksum="81EE1ECA9649C2D2" modified="2014-10-29" version="1">MNSRFARAGDTIERLVENSFRAIDDGAYELKRSVSHDAISVKKAIFVCKHAPLITEVKFSSPSRGKIREVGTPAEIAIAMEEAGATALSVLTQPYMFDGSLGNLLAVRKAVSIPLLMKDIIVSEVQIDAAKQAGADCILLIKTVFDRDLAESGIEKLYEYALKKRELNVLVEAHSEGEYADCLSANYELVGINNRNLADLKIDMANTERLIKKLGKGRSVIISESGIAKPADIKYLREAGADAFLVGTSIMETDDVGTKVRELYNAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MS51</accession>
    <name>A0A075MS51_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Trm112p-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02308</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700945.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MS51"/>
    <dbReference type="STRING" id="1459636.NTE_02308"/>
    <dbReference type="GeneID" id="41598023"/>
    <dbReference type="KEGG" id="nev:NTE_02308"/>
    <dbReference type="eggNOG" id="arCOG04124">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_155659_4_3_2"/>
    <dbReference type="OrthoDB" id="6467at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005651">
        <property type="entry name" value="Trm112-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03966">
        <property type="entry name" value="Trm112p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158997">
        <property type="entry name" value="Trm112p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="90" mass="10607" checksum="9C96AB95C7A67444" modified="2014-10-29" version="1">MKRSMLDILQCPIDRHYPLELFEIEVAGDGEIREGVLACAKCGRYYPIMEEIPVMLPDELRNKERDVGFLQRWQAKIPEKILRQGNPWHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MS74</accession>
    <name>A0A075MS74_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chemotaxis protein CheC, inhibitor of MCP methylation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_02349</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MS74"/>
    <dbReference type="STRING" id="1459636.NTE_02349"/>
    <dbReference type="KEGG" id="nev:NTE_02349"/>
    <dbReference type="eggNOG" id="arCOG02381">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087860_2_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17905">
        <property type="entry name" value="CheC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1550.10">
        <property type="entry name" value="CheC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007597">
        <property type="entry name" value="CheC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028976">
        <property type="entry name" value="CheC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050992">
        <property type="entry name" value="CheZ_family_phosphatases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43693">
        <property type="entry name" value="PROTEIN PHOSPHATASE CHEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43693:SF1">
        <property type="entry name" value="PROTEIN PHOSPHATASE CHEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04509">
        <property type="entry name" value="CheC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103039">
        <property type="entry name" value="CheC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheC-like protein" evidence="3">
        <location>
            <begin position="102"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF84401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="195" mass="21472" checksum="4BE6C517D0535BF7" modified="2014-10-29" version="1">MELKTLKELLNSYIRTKTMPAFSMILGEEVEYSVRSMNMLHLQDIDGILLPFMNQEMCAIYLRAEGDVHIGMLLFMQESQALTLAARLLGKEAMDRLDTLGKSSLAEVGNILLAGSFLNAISNSTGFRIDCSVPGFAIESLGAILGDPISEIAARTNSLILAGVELRSLKSNVRVYIFLFFGPEDIKKLLAHAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSB2</accession>
    <name>A0A075MSB2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00157</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_264357931.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSB2"/>
    <dbReference type="STRING" id="1459636.NTE_00157"/>
    <dbReference type="GeneID" id="75933603"/>
    <dbReference type="KEGG" id="nev:NTE_00157"/>
    <dbReference type="HOGENOM" id="CLU_3245483_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="42" mass="4763" checksum="E1AB3A438F315761" modified="2014-10-29" version="1">MSSDVPRCKECGMVFDTVESLEEHVKNEKQEVAERHKGIDDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSF2</accession>
    <name>A0A075MSF2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">3-hydroxyacyl-CoA dehydrogenase</fullName>
            <ecNumber evidence="4">1.1.1.35</ecNumber>
            <ecNumber evidence="4">4.2.1.55</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_02462</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.35" evidence="4"/>
    <dbReference type="EC" id="4.2.1.55" evidence="4"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701074.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSF2"/>
    <dbReference type="STRING" id="1459636.NTE_02462"/>
    <dbReference type="GeneID" id="41598169"/>
    <dbReference type="KEGG" id="nev:NTE_02462"/>
    <dbReference type="eggNOG" id="arCOG00249">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_2_0_2"/>
    <dbReference type="OrthoDB" id="39812at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003857">
        <property type="term" value="F:(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000009">
        <property type="entry name" value="Fatty oxidation complex, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075">
        <property type="entry name" value="3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075:SF5">
        <property type="entry name" value="3-HYDROXYBUTYRYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase NAD binding" evidence="3">
        <location>
            <begin position="7"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase C-terminal" evidence="2">
        <location>
            <begin position="190"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF84511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="382" mass="42712" checksum="6A0C45F768A675DA" modified="2014-10-29" version="1">MSVSINKITVLGSGVMGHGIAQVSAMAGYNVTLRDIEQSFLDKAMEKIRWSLNKLVEKQKLSQQDADKIFARITPVVDLKTALKGADLLIEAVPEDMNLKKKVYAEVDSFAEDKTLYASNTSTLPITDMAALTSRPERFIGLHFFNPPQLMPLVEVIPGAKSNAGMVDMAMDYCKKVGKQPVLCKKDVPGFIVNRVFIPLVHEAVYCMERDNASMTQIDSAVKFRMSFPMGIFELADYTGLDVIHKATVEMHMRDAKVIFPHPKIKQLFDEKNLGQKTGKGFYEYKGDKYERVNLTEQEAATYNPIKLLAVAANNAAWLITNGVCDRAELEKALKLGMGLKKELFATMQEFGPQNVVKTLQELAAKYGQFYQPDPYLVSYRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSL4</accession>
    <name>A0A075MSL4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">dUTPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01721</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSL4"/>
    <dbReference type="STRING" id="1459636.NTE_01721"/>
    <dbReference type="KEGG" id="nev:NTE_01721"/>
    <dbReference type="eggNOG" id="arCOG08766">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105318_2_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd11527">
        <property type="entry name" value="NTP-PPase_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4010.10">
        <property type="entry name" value="Type II deoxyuridine triphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014871">
        <property type="entry name" value="dUTPase/dCTP_pyrophosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08761">
        <property type="entry name" value="dUTPase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101386">
        <property type="entry name" value="all-alpha NTP pyrophosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="110" mass="12738" checksum="418B25A36C149919" modified="2014-10-29" version="1">MMDTLETIFSMQKELANMMDLSRYPATTEGKVSALSTAIIHEAVELQRLTNWKWWKKPSGFDEAAAREELIDIWHFVVQASLELGMTPADILDEYKKKNQVNRDRQKSGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSL6</accession>
    <name>A0A075MSL6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02092</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385359.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSL6"/>
    <dbReference type="GeneID" id="43502638"/>
    <dbReference type="KEGG" id="nev:NTE_02092"/>
    <dbReference type="HOGENOM" id="CLU_207596_0_0_2"/>
    <dbReference type="OrthoDB" id="376201at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="48" mass="5254" checksum="88D465CCD463CB95" modified="2014-10-29" version="1">MSVNGSPRRCNCDECRDTYSILQELDLFAPAGKAIAAEKKRAITAMAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSP3</accession>
    <name>A0A075MSP3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02105</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700786.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSP3"/>
    <dbReference type="GeneID" id="41597837"/>
    <dbReference type="KEGG" id="nev:NTE_02105"/>
    <dbReference type="HOGENOM" id="CLU_1222476_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="226" mass="25943" checksum="47933F4AB71ED8B5" modified="2014-10-29" version="1">MRLENKPIVSLGAADKREIAHCNRVIIRTFVELKAKGKINPTYAEELGRIEIFLRYAKVCAIGMNAIDRVIDPDNVQRFQEFKNDISQYGITAENFMNVHTSLLLYNFLQFYSQAENIMIALLKGATYGKNNNQTVTGKEELGRLINDVIGSVYKNNGLSEFVDTKFRNALAHGWCFVNDDRLHYYTDGTLKNLQSLSIYELLLKFRKMNLFTLALMQTVTHTSWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSP7</accession>
    <name>A0A075MSP7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSP7"/>
    <dbReference type="STRING" id="1459636.NTE_02110"/>
    <dbReference type="KEGG" id="nev:NTE_02110"/>
    <dbReference type="HOGENOM" id="CLU_2730143_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="71" mass="8063" checksum="AAF3F67F729A62CC" modified="2014-10-29" version="1">MINKKGDIKFSKIDDYTVEGLLSTLTREFGLFSCKKCGAMVILPDTENKGDTRSLQAHSAWHDMQTKVKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSS3</accession>
    <name>A0A075MSS3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glucose/sorbosone dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02582</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226986983.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSS3"/>
    <dbReference type="STRING" id="1459636.NTE_02582"/>
    <dbReference type="GeneID" id="41598276"/>
    <dbReference type="KEGG" id="nev:NTE_02582"/>
    <dbReference type="eggNOG" id="arCOG02796">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_677373_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012938">
        <property type="entry name" value="Glc/Sorbosone_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH_b-prop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19328">
        <property type="entry name" value="HEDGEHOG-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19328:SF13">
        <property type="entry name" value="HIPL1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07995">
        <property type="entry name" value="GSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="Soluble quinoprotein glucose dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose/Sorbosone dehydrogenase" evidence="1">
        <location>
            <begin position="64"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="442" mass="47747" checksum="7D8D393CB8C44BCE" modified="2014-10-29" version="1">MKKRAFVGLSIAGAIAVAIAGIIIVVPDVALPFKTSGSTTEVENSGPELRDGTLALEQVVAGGLQFPTSMAFLDADNILVLQKNDGQVRLVSGGVLAEKPVLQVNVENDVERGLLGIAVWNGSSVSSNEVFLYLTENVTDGGNTTTAMNRIYRYNYDWSQKALVNGTLLLDLAGGPGPYHNGGKIAIGPDGYLYAVIGDTNFSTGISDNHASREPPDYRSVIIRVDRETGKAPSDNPFYGIKGLERVYAYGIRNSFGMDFDPITNSLWMTENGPTTYDEINVVHPGFNSGWDKFTGPIAKSNATMDDLAMVEGAKYSDPAFSWYIPVGVTDIEFFDSDKLGEKYKDNIFVGDVNNGNLYFFEADQNRTGLYFGYEQSSLADLIADPVPDKDTGRLDGELPSITLGKGFAAITDIETGPDGYLYVLTHIDGKIYRITPTGTGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSV3</accession>
    <name>A0A075MSV3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01806</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSV3"/>
    <dbReference type="STRING" id="1459636.NTE_01806"/>
    <dbReference type="KEGG" id="nev:NTE_01806"/>
    <dbReference type="HOGENOM" id="CLU_543602_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="501" mass="55133" checksum="F9F2AF863BAB2CF5" modified="2014-10-29" version="1">MLKTGNAKTSLIALAVIALVISTSILMPMQQAAAAKPTHTDIQNVINLASGYINALYKDSSPAEVGSSTNAVMAEYPALPIRVVQSDGRVIRAGEDVNIWTGWKTNVLDTFSETASDSIKYRIHMRSKDIFNSVYDKSPLLEVTVDYDYGASHNVKVDVKNLQWDAGAPVSYADVYIGNVYLGRATPANVGTTWSYTSSVNNSNDVFFRSFRYIERHGTQLGREWYNAVGDTSKATELANRLTSEGYTLSKDIYSPMFGSASAQATNYQYESGSTGVYRDCYTEPSLRDQSYQYHSKVCNGVDAYIIYSRSSDWLVPTLWAIHQLNKGVGVDTPIYDGYQTWSPRQVARFVEGKWIADIGVKSPYSNTQASAVRTAAFLTLETMLGYGSTNDATSRTYADKAASALLNPQIKSNGVVTRENEDGSFTSLTRPLLKGGVYTAWNGFNYVTKNSILQSMSDSFNQPDETLDIKPSNAESTITVAQALRVYDCYNYGSNCLNTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MT67</accession>
    <name>A0A075MT67_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02353</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MT67"/>
    <dbReference type="STRING" id="1459636.NTE_02353"/>
    <dbReference type="KEGG" id="nev:NTE_02353"/>
    <dbReference type="eggNOG" id="arCOG02037">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071484_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051797">
        <property type="entry name" value="TrmB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002831">
        <property type="entry name" value="Tscrpt_reg_TrmB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34293">
        <property type="entry name" value="HTH-TYPE TRANSCRIPTIONAL REGULATOR TRMBL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34293:SF1">
        <property type="entry name" value="HTH-TYPE TRANSCRIPTIONAL REGULATOR TRMBL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01978">
        <property type="entry name" value="TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription regulator TrmB N-terminal" evidence="1">
        <location>
            <begin position="81"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="335" mass="37764" checksum="87ADAAE7C9300EE1" modified="2014-10-29" version="1">MTNKIRYATYFHVCSYSTYKVLNNFFLDWPSIMASSSIKKVYDVDLDLSEIEDSSIYGRNKIDYAFAKYFLTVQKKLLPDLQKLDLSLNEARILLFLMIRKHSTATDVSKYTGIGRTETYHYLSNLLSKGVVLSTFDRPQKYYALPYTEAVDCLVRAKQNALRAVSENKDEHQNIINSIVEGMVVPEQGGKESYQVIVGEDPVHAKIARMLSAAKTEASVLLSDRYMVDLYYSEMTDALFGLAEKGVKVRLHTSCAKISKFINDETEVDMRAVGLKVVDGASTPVDFVIVDDQEMIILLNSRPAPSKKQESCGFYTNNQSLIAAFKFMFNKTGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MT87</accession>
    <name>A0A075MT87_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UbiA prenyltransferase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700927.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MT87"/>
    <dbReference type="STRING" id="1459636.NTE_02280"/>
    <dbReference type="GeneID" id="41597995"/>
    <dbReference type="KEGG" id="nev:NTE_02280"/>
    <dbReference type="eggNOG" id="arCOG00480">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1105239_0_0_2"/>
    <dbReference type="OrthoDB" id="11689at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="236" mass="25711" checksum="2681629F4FD72C36" modified="2014-10-29" version="1">MTESRMNEWFVPRFGPPRFRAFVGLLFLPYTGMCIAFTLIGAMLVPPNDIHWDRVGAIVFIYALALGVGAHAADAIGSKKAKPWGAYFTRRQMVALLALSLAGAYAIGIYYIVFYVPALAIAAVLEGFLLFAYNFEIWKGRFHTNFWFAVSWGALPVTAGYTIQTGNVVALAPLAAAAGAGLASMAEIRMSRPYKQLKREGGDPVAAKRLERRLKLLSLATIAFSLLFVAARAVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTA0</accession>
    <name>A0A075MTA0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01969</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385311.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTA0"/>
    <dbReference type="STRING" id="1459636.NTE_01969"/>
    <dbReference type="GeneID" id="41597717"/>
    <dbReference type="KEGG" id="nev:NTE_01969"/>
    <dbReference type="eggNOG" id="arCOG04806">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131496_11_1_2"/>
    <dbReference type="OrthoDB" id="8931at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050744">
        <property type="entry name" value="AI-2_Isomerase_LsrG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33336:SF15">
        <property type="entry name" value="ABM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33336">
        <property type="entry name" value="QUINOL MONOOXYGENASE YGIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="18"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="114" mass="12954" checksum="D8BB7B5B9A64CBC0" modified="2014-10-29" version="1">MKPTTDPEKYKLVTSESVRVIASFKAKPGQQEALKQILMSLVEPTRSELGCIAYILHQDTNDIRHLVFDEIWVNMQALKEHAAKPYIRALSQRLQGIVSEPPVVETFYEVLLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTA5</accession>
    <name>A0A075MTA5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02388</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTA5"/>
    <dbReference type="KEGG" id="nev:NTE_02388"/>
    <dbReference type="HOGENOM" id="CLU_2257465_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="103" mass="11683" checksum="8A61A64E7E24D1E7" modified="2014-10-29" version="1">MPFSFVTYCKICKLDRQFALYQTDMMQDGQMLMHGTCVICNNEAVKNMGEVISIQARCPKCRNEVGIITFDGDPTEPLKGCSICGYSEQLDVIEMRCGRENIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTB3</accession>
    <name>A0A075MTB3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase propeptide domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_02765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701315.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTB3"/>
    <dbReference type="STRING" id="1459636.NTE_02765"/>
    <dbReference type="GeneID" id="41598454"/>
    <dbReference type="KEGG" id="nev:NTE_02765"/>
    <dbReference type="HOGENOM" id="CLU_1590939_0_0_2"/>
    <dbReference type="OrthoDB" id="374810at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025711">
        <property type="entry name" value="PepSY"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03413">
        <property type="entry name" value="PepSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="PepSY" evidence="2">
        <location>
            <begin position="122"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF84806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="168" mass="18759" checksum="32C978EAA84BCC67" modified="2014-10-29" version="1">MSSATNGSQGLKKNKMSLRVLTVALFAFGIFAAAALLYQQKFAASSKPYAISKDDATRIALNQVDREPNRDASLFPDKESTAKLIHVTANGLAFMADDEKSPSADMWLYTKEHRFLQAYWNQHFWHVEVTTSGNDGYRGYYYLIDAKSGQVIGNDRDLAFFDLSATDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTD4</accession>
    <name>A0A075MTD4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">C2H2-type zinc finger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02806</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385551.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTD4"/>
    <dbReference type="STRING" id="1459636.NTE_02806"/>
    <dbReference type="GeneID" id="43502660"/>
    <dbReference type="KEGG" id="nev:NTE_02806"/>
    <dbReference type="eggNOG" id="arCOG10404">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_214142_0_0_2"/>
    <dbReference type="OrthoDB" id="5600at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="6"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="42" mass="4777" checksum="78E9B505E692C617" modified="2014-10-29" version="1">MEEDQVSCPYCGSAFKDKEQLSKHIDRIHHGSGLLEGDTTKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTD7</accession>
    <name>A0A075MTD7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptide methionine sulfoxide reductase MsrB</fullName>
            <ecNumber evidence="6">1.8.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Peptide-methionine (R)-S-oxide reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">msrB</name>
        <name evidence="8" type="ORF">NTE_02811</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>L-methionyl-[protein] + [thioredoxin]-disulfide + H2O = L-methionyl-(R)-S-oxide-[protein] + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:24164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12314"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:45764"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit. The zinc ion is important for the structural integrity of the protein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the MsrB Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.12" evidence="6"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701357.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTD7"/>
    <dbReference type="STRING" id="1459636.NTE_02811"/>
    <dbReference type="GeneID" id="41598498"/>
    <dbReference type="KEGG" id="nev:NTE_02811"/>
    <dbReference type="eggNOG" id="arCOG02815">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031040_8_5_2"/>
    <dbReference type="OrthoDB" id="5961at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033743">
        <property type="term" value="F:peptide-methionine (R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.150.20:FF:000001">
        <property type="entry name" value="Peptide methionine sulfoxide reductase MsrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.20">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01400">
        <property type="entry name" value="MsrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028427">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002579">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00357">
        <property type="entry name" value="peptide-methionine (R)-S-oxide reductase MsrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10173">
        <property type="entry name" value="METHIONINE SULFOXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10173:SF52">
        <property type="entry name" value="METHIONINE-R-SULFOXIDE REDUCTASE B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01641">
        <property type="entry name" value="SelR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51790">
        <property type="entry name" value="MSRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MsrB" evidence="7">
        <location>
            <begin position="11"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF84851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="134" mass="15013" checksum="09A04312BD0397E2" modified="2014-10-29" version="1">MSNKKKPADDDRDNFSHLSQEQREVCWNKGTEAPFTGKYWNSHEKGVYRCAACGAELFSSDTKFDSGTGWPSFYKPVKDANVKEETDTSYGMVRTEVMCSKCGAHLGHVFDDGPNPTGLRYCINSLSLDLEKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTE9</accession>
    <name>A0A075MTE9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00498</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699526.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTE9"/>
    <dbReference type="STRING" id="1459636.NTE_00498"/>
    <dbReference type="GeneID" id="41596371"/>
    <dbReference type="KEGG" id="nev:NTE_00498"/>
    <dbReference type="HOGENOM" id="CLU_757803_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="210"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="365" mass="39326" checksum="C56AFF0BD07E365F" modified="2014-10-29" version="1">MTAGSTRDGYFRRIVEGTIGAGPDRVPAVKLALKPESLDSIGAPRNMALHPKPLTDAYSRTPPLSNGDFREGNRQSASKDDHQPADAKSAKAEPPRRQVVARDDKSTLSSLDSKLPESDGIPEKDVNVNSAHVKPQERGFAIPKSPNKTGINSQRDQPETKHDLDSIKSDSPKDSAGVMNEGERTEFAPLDKGDRSRRDAFDGRKDDNDAASNSQAAAPALAGAPPSVPSKGAEETIVRVDSDDKITGGRLPAALPPSAVRNLRRDEDSFLQQSTHARLAQQGDGEAKSASADSISATSVRPTYVEYKKRDVREKASETIVTVNIGRIEIRAPAQPKPSEHPVSPPAFSPPLSLAEYLRRRNAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTK5</accession>
    <name>A0A075MTK5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_02396</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701021.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTK5"/>
    <dbReference type="GeneID" id="41598108"/>
    <dbReference type="KEGG" id="nev:NTE_02396"/>
    <dbReference type="HOGENOM" id="CLU_1478849_0_0_2"/>
    <dbReference type="OrthoDB" id="381699at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF84448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="182" mass="18600" checksum="E294F5C26649DEF5" modified="2014-10-29" version="1">MVQKNLQKAVIAGGTAALAVAIVAFALVFFAQGAKPSVPASEEVDDNNDNYNNGSASDNTSTTTTTVVGKTASATSLECHNDSQAGTTTIVISAKLADKSSGHGVPGKQVIFTILPGNPVAVLSTDSLGQASVSLNASEFSEERSAVFIFFDGDEEYEFSSCRLDIVTPHASPGEPAAGANS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTM3</accession>
    <name>A0A075MTM3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02428</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701046.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTM3"/>
    <dbReference type="STRING" id="1459636.NTE_02428"/>
    <dbReference type="GeneID" id="41598137"/>
    <dbReference type="KEGG" id="nev:NTE_02428"/>
    <dbReference type="HOGENOM" id="CLU_1381450_0_0_2"/>
    <dbReference type="OrthoDB" id="378537at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="199" mass="20754" checksum="1EDC647F06D2AB7B" modified="2014-10-29" version="1">MVAAQDKNTVVSLQKNRGLAVAGAGAASGLIGSLAISALILLAERVAGLPVGTFYLMLVSAMSQAQDYNTLAIVQGLLLHMLAGTALGLVISAPFAVSKKAYISLGRFAPAYGLAAGVLVWAALFLPVTYGTMMPLLQSLDGQSVISQRVPIGTLFSIAVSDMLAMMDRIIYTALAFNMLFGLVTLMLTRAFAEAIIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTN2</accession>
    <name>A0A075MTN2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00563</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTN2"/>
    <dbReference type="STRING" id="1459636.NTE_00563"/>
    <dbReference type="KEGG" id="nev:NTE_00563"/>
    <dbReference type="HOGENOM" id="CLU_3263607_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="41" mass="4694" checksum="13E41929C7163E06" modified="2014-10-29" version="1">MGTLSSGYGEWQQFKTSLSCEGYECHLPKYYNDEVCRNVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTS2</accession>
    <name>A0A075MTS2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Methionine synthase (B12-dependent)</fullName>
            <ecNumber evidence="21">2.1.1.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">NTE_02986</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">SR1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>methylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:28115"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the vitamin-B12 dependent methionine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.13" evidence="21"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTS2"/>
    <dbReference type="STRING" id="1459636.NTE_02986"/>
    <dbReference type="KEGG" id="nev:NTE_02986"/>
    <dbReference type="eggNOG" id="arCOG01978">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG02029">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004914_4_1_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008705">
        <property type="term" value="F:methionine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050667">
        <property type="term" value="P:homocysteine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046653">
        <property type="term" value="P:tetrahydrofolate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.20:FF:000007">
        <property type="entry name" value="Methionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.280:FF:000008">
        <property type="entry name" value="Methionine synthase (MetH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.280">
        <property type="entry name" value="Cobalamin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="entry name" value="Dihydropteroate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1240.10">
        <property type="entry name" value="Methionine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.196.10">
        <property type="entry name" value="Vitamin B12-dependent methionine synthase, activation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003759">
        <property type="entry name" value="Cbl-bd_cap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050554">
        <property type="entry name" value="Met_Synthase/Corrinoid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011822">
        <property type="entry name" value="MetH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036594">
        <property type="entry name" value="Meth_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004223">
        <property type="entry name" value="VitB12-dep_Met_synth_activ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037010">
        <property type="entry name" value="VitB12-dep_Met_synth_activ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45833">
        <property type="entry name" value="METHIONINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45833:SF1">
        <property type="entry name" value="METHIONINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02607">
        <property type="entry name" value="B12-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02965">
        <property type="entry name" value="Met_synt_B12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000381">
        <property type="entry name" value="MetH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01018">
        <property type="entry name" value="B12-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="Cobalamin (vitamin B12)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="Dihydropteroate synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56507">
        <property type="entry name" value="Methionine synthase activation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47644">
        <property type="entry name" value="Methionine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50974">
        <property type="entry name" value="ADOMET_ACTIVATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51337">
        <property type="entry name" value="B12_BINDING_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 14" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="12" id="KW-0170">Cobalt</keyword>
    <keyword evidence="8 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="3 21" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 15" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 21" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Pterin-binding" evidence="17">
        <location>
            <begin position="26"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="B12-binding N-terminal" evidence="20">
        <location>
            <begin position="315"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="B12-binding" evidence="19">
        <location>
            <begin position="429"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="AdoMet activation" evidence="18">
        <location>
            <begin position="577"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="580"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="439"/>
            <end position="443"/>
        </location>
        <ligand>
            <name>methylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:28115"/>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="442"/>
        </location>
        <ligand>
            <name>methylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:28115"/>
        </ligand>
        <ligandPart>
            <name>Co</name>
            <dbReference type="ChEBI" id="CHEBI:27638"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="487"/>
        </location>
        <ligand>
            <name>methylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:28115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="545"/>
        </location>
        <ligand>
            <name>methylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:28115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="787"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="841"/>
            <end position="842"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000381-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000381-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="AIF85021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="844" mass="92725" checksum="1D33FACA66AE94C3" modified="2014-10-29" version="1">MGALLNKVPRVSSALKAVDLKQEPAPLIIGERLNTLGSKKAKAMVLKDDFDGLANLAREQVEDGAHCLDVCVATTERSDELEFMKKLVKRLSLEVEAPLVIDSTDPKVVEAAVEQIPGRPIINSINLEGDGSRFHALAPIMAKYGLPAIAMCIGPNGMAKTADEKVETAQLLYDTGKKYGLEPWQFIFDVLTFTIGTGEAEYADSAKNTLEGIRLVKQRFPAAFTTLGLSNVSFGLPAGSRKVVNSVFLYHALKAGLDTVIINARDIIPYPEIDAEQRKLAEDLIFNKHQNALADLIAYFEGEKAKVASGTASKRVEVDPSWDADRKCHFRIVNRLKDGIEADVVQAIAGRVPGARVADGKITEAEKEAAHEAAVQTLNDVLLPAMKEVGDKFGAGELILPFVLKSAECMKAAVAELEKYLIKQEGVSKGKLVLCTVYGDVHDIGKNLVKTIFANNGYTVYDLGKQVPMQKILEKIEEVKPDAVGLSALLVSTSKQMQYFVEHARQNGMAVPVLCGGAAINSNYINRIAKDGGIYGPGVFYCKTAFDGLRAMNALVSKEQRAQFVGDWRQKLEKWTEREATAAETATELPHSGIKPVEPPVAPHLNRQVRLGPADLDLKEIWKHISKKSLFVLQWGMRGKGASEGGDPEKLFAEWTGRVIDECLFEPRAVYGYFRCHNLTLGKNGAAGRLAVDFSDNRQAVFEFPRSSKEKHLCLADYFGQDDVAAFQAVTVGTKVTEVIDRWNKQDSYADAYYLHGLAVETAEAMAEWVNARIRKELGIGDKRGLRYSWGYPSCPDVMQHHLVWQILEPEKSGMTLTESGQIVPDQSTAAIVVHHPQAEYFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTU9</accession>
    <name>A0A075MTU9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CRISPR-associated endonuclease Cas1</fullName>
            <ecNumber evidence="9">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">cas1</name>
        <name evidence="10" type="ORF">NTE_02571</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer, forms a heterotetramer with a Cas2 homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the CRISPR-associated endonuclease Cas1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="9"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701155.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTU9"/>
    <dbReference type="STRING" id="1459636.NTE_02571"/>
    <dbReference type="GeneID" id="41598266"/>
    <dbReference type="KEGG" id="nev:NTE_02571"/>
    <dbReference type="eggNOG" id="arCOG01452">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052779_0_1_2"/>
    <dbReference type="OrthoDB" id="2216at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09634">
        <property type="entry name" value="Cas1_I-II-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.920">
        <property type="entry name" value="CRISPR-associated endonuclease Cas1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.20">
        <property type="entry name" value="CRISPR-associated endonuclease Cas1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01470">
        <property type="entry name" value="Cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050646">
        <property type="entry name" value="Cas1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002729">
        <property type="entry name" value="CRISPR-assoc_Cas1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042206">
        <property type="entry name" value="CRISPR-assoc_Cas1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042211">
        <property type="entry name" value="CRISPR-assoc_Cas1_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00287">
        <property type="entry name" value="cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34353">
        <property type="entry name" value="CRISPR-ASSOCIATED ENDONUCLEASE CAS1 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34353:SF2">
        <property type="entry name" value="CRISPR-ASSOCIATED ENDONUCLEASE CAS1 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01867">
        <property type="entry name" value="Cas_Cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="7 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 9 10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 9" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIF84615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="318" mass="36217" checksum="56CFCD4CB4290CFD" modified="2014-10-29" version="1">MILEISSHGSVLKRQNDLFIVKNEDGKSEVPAEKVDAIITSANILISSQAIKLCIEKNIQLVVTDWAGRPVARLWVSTAGKSTELRRRQYANQDTVLGVQISIELVRTKLKRQKEFLQDLKNNRKVDVPEITRAIDIISDALLQIRKLQPDNRVKQSLLGLEGTSASAYFRAISSSLPSKWSFEHRSQYPALDGFNALLNYAYGIAYSDVEKIIILSGLDPNSGFYHADSYGKPTLSFDLMELVRPLIDRTVVSLFNKKMVSERWFEKNDDSSIFLKKDARLTLLTSYSEKNRKELEKITWRFCREIIERLTSGDKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTZ7</accession>
    <name>A0A075MTZ7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Short-chain alcohol dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_02584</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701165.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTZ7"/>
    <dbReference type="STRING" id="1459636.NTE_02584"/>
    <dbReference type="GeneID" id="41598278"/>
    <dbReference type="KEGG" id="nev:NTE_02584"/>
    <dbReference type="eggNOG" id="arCOG01259">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_2"/>
    <dbReference type="OrthoDB" id="24596at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF40">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF84628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="229" mass="24955" checksum="DC0268C68B33C0F6" modified="2014-10-29" version="1">MIMVTAIVTGSGRGIGRATALLLAKKGVNVVVCSRTKSEVDDTVDETRKFHEGVLGVVCDVGVASLVDSLAKKAVARFGQIDILVNNAGIFYIKKLVDTSEKEWDDTMNSNLKSAFLCSKAVLPHLTKTGTIINVSSGAGKTGFENLSAYCASKFGMMGLTESLSWEVQNGVRVMAICPGEVDTRMQESDPVYYRQNRSRMLKPEQVAEKIAEMIFDKRSYRNGQSVDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MU67</accession>
    <name>A0A075MU67_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA repair photolyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_02645</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701215.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MU67"/>
    <dbReference type="STRING" id="1459636.NTE_02645"/>
    <dbReference type="GeneID" id="41598338"/>
    <dbReference type="KEGG" id="nev:NTE_02645"/>
    <dbReference type="eggNOG" id="arCOG01290">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015525_1_1_2"/>
    <dbReference type="OrthoDB" id="15538at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040086">
        <property type="entry name" value="MJ0683-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43432:SF4">
        <property type="entry name" value="RADICAL SAM CORE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43432">
        <property type="entry name" value="SLR0285 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01084">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Radical SAM core" evidence="4">
        <location>
            <begin position="28"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF84688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="322" mass="37169" checksum="3D2A733FAEEB3478" modified="2014-10-29" version="1">MSSGLWYDVSAPRYEAKKAKSIIHPFAVKGYTGMTVNPYQGCQHRCAYCYATYEWSPEFYDKVYAKSNAPEVLEKELQSWKASTINPMMVASATDAYQPAELRYGLTRKCVQVLQKYNVPYYVFTKSTIIERDLELHRRYARNCLVIWSITTANEKIRRIVEPGTPPAERIFAVIKKFTDAGVPCGINVDPIMPLVTDTDEELGAVVDRCKEAGVKYVFGAMLRMRDDIWDRMKLALRLLQVPDGERRYRQIYEIKEELSADAKQKYIACNKEYGKRVTDRLHEIIKSRGLCPDFPDHVRPQDIDRSCTGQMTMLSFVHRDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUF2</accession>
    <name>A0A075MUF2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable tRNA pseudouridine synthase B</fullName>
            <ecNumber evidence="3">5.4.99.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">tRNA pseudouridine(55) synthase</fullName>
            <shortName evidence="3">Psi55 synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">tRNA pseudouridylate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">tRNA-uridine isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">truB</name>
        <name evidence="6" type="ORF">NTE_02790</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>uridine(55) in tRNA = pseudouridine(55) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:42532"/>
            <dbReference type="Rhea" id="RHEA-COMP:10101"/>
            <dbReference type="Rhea" id="RHEA-COMP:10102"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pseudouridine synthase TruB family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="3"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701338.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUF2"/>
    <dbReference type="STRING" id="1459636.NTE_02790"/>
    <dbReference type="GeneID" id="41598478"/>
    <dbReference type="KEGG" id="nev:NTE_02790"/>
    <dbReference type="eggNOG" id="arCOG00987">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032087_3_0_2"/>
    <dbReference type="OrthoDB" id="35866at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160148">
        <property type="term" value="F:tRNA pseudouridine(55) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000495">
        <property type="term" value="P:box H/ACA sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031118">
        <property type="term" value="P:rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21148">
        <property type="entry name" value="PUA_Cbf5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01081">
        <property type="entry name" value="TruB_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012960">
        <property type="entry name" value="Dyskerin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004802">
        <property type="entry name" value="tRNA_PsdUridine_synth_B_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026326">
        <property type="entry name" value="TruB_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032819">
        <property type="entry name" value="TruB_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00425">
        <property type="entry name" value="CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003280">
        <property type="entry name" value="PRK04270.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23127">
        <property type="entry name" value="CENTROMERE/MICROTUBULE BINDING PROTEIN CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23127:SF0">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT DKC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08068">
        <property type="entry name" value="DKCLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16198">
        <property type="entry name" value="TruB_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01136">
        <property type="entry name" value="DKCLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Dyskerin-like" evidence="5">
        <location>
            <begin position="4"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="PUA" evidence="4">
        <location>
            <begin position="240"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF84830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="351" mass="39202" checksum="E29B3BD38FEE9FBD" modified="2014-10-29" version="1">MLPQLENLVNVDEDVTDERYGHYPDKRPISELLYYGLILIDKPAGPTSHEVVAWVKRILEIEKAGHSGTLDPGATGLLPIGLGEGTKALGVLLLGPKEYYALARLHAHAPADKVRRTMKEFTGEIYQRPPQRSSVKRVTRVRTVYEFDYIEDYDRLILMRILCQAGTYIRKIIYDIGEVLSPGATMVELRRTQVSNLYEKDGLVRLHDLADAYQRYKETGDEEKLRRLVLPIERCLEGIRGITVRDTAVDALCHGAPLAVPGVIAVPKDLRAGELVGVYTLKGEIVGLAEAAMTKEQIEESARGVAFVMKRLIMRPDTYPKAWRSRGEHAAAPDVAIHPEVDLGKLESDDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUI0</accession>
    <name>A0A075MUI0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701289.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUI0"/>
    <dbReference type="STRING" id="1459636.NTE_02731"/>
    <dbReference type="GeneID" id="41598421"/>
    <dbReference type="KEGG" id="nev:NTE_02731"/>
    <dbReference type="HOGENOM" id="CLU_194243_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="74" mass="7930" checksum="2D92FB660D711169" modified="2014-10-29" version="1">MGLELFIVAMWVMVLAVSAFLVLAIAPLDIAMKGSPRIAVSAVQAVIAIAAVALLAFGLSRLKRAYANRKLYRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUK9</accession>
    <name>A0A075MUK9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase M3A/M3B catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02324</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700958.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUK9"/>
    <dbReference type="STRING" id="1459636.NTE_02324"/>
    <dbReference type="GeneID" id="41598040"/>
    <dbReference type="KEGG" id="nev:NTE_02324"/>
    <dbReference type="eggNOG" id="arCOG04758">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_622046_0_0_2"/>
    <dbReference type="OrthoDB" id="7197at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="491" mass="57212" checksum="395C40B5DF1CD902" modified="2014-10-29" version="1">MNLEQWCQLDERIYVAESDERYRQYAGLKHSIKAIERLAEMKSLAARLFLENFEEPRELYLSSIESMADSSTKKLELKLYDLRNTRVVSRQARFNGRPVNWSSWRQYNSAEKDSKKRKAVFDEFVKKTRFVAPVVKARFDAIADVYAKQSSSKKKLDPLAGYLENEKFTYSQLMDFVKSMGRQAKKPFREALLGVSNKVLGRPAEYYDDFYFFRNRVYSDLEKHFSGIDPTAQVKRTLEGLGFDLSRIKIDAENRKDKYPSPICFFVQVPNDIRVLYKSESPYFDLQGCYHEMGHAAHATSIDPALDYWDRYGFSMGIAEIFSIFLERLTKNRRYLKSLGVTDERVLDELAQRNNFMELFFVTFYTANSIMKAEFWRKKLSTRQASDLYGKLLSEYVGLDVPGEYWMLHHILPDAIMYVPSYIIAAVRAAELEKHLQDRFGEEWWTVKEAGEEIRRFMRPGAKIELPAFSKMDASLFVNEIITSSSSSGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUM5</accession>
    <name>A0A075MUM5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Roadblock/LAMTOR2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02782</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUM5"/>
    <dbReference type="STRING" id="1459636.NTE_02782"/>
    <dbReference type="KEGG" id="nev:NTE_02782"/>
    <dbReference type="eggNOG" id="arCOG08684">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128582_0_1_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046600">
        <property type="entry name" value="DUF6659"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20364">
        <property type="entry name" value="DUF6659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="134" mass="15167" checksum="10CC59F505C387AA" modified="2014-10-29" version="1">MNESSLLSKFFPYPVVLPDLDELCKKVFAVDPAIRFAGVIDKMGRLVAGGMRTGLSPLESVRDMDKLYIEFALRNAMRKEFNADFGKTIFTFSERERIKLATFPLQDDDNLLLVSIEKDKPHDKIISGILAVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUM6</accession>
    <name>A0A075MUM6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chemotaxis signal transduction protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700978.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUM6"/>
    <dbReference type="STRING" id="1459636.NTE_02345"/>
    <dbReference type="GeneID" id="41598061"/>
    <dbReference type="KEGG" id="nev:NTE_02345"/>
    <dbReference type="eggNOG" id="arCOG02395">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048995_3_1_2"/>
    <dbReference type="OrthoDB" id="115049at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.180">
        <property type="entry name" value="CheA-289, Domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039315">
        <property type="entry name" value="CheW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036061">
        <property type="entry name" value="CheW-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002545">
        <property type="entry name" value="CheW-lke_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22617:SF23">
        <property type="entry name" value="CHEMOTAXIS PROTEIN CHEW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22617">
        <property type="entry name" value="CHEMOTAXIS SENSOR HISTIDINE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01584">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00260">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50341">
        <property type="entry name" value="CheW-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50851">
        <property type="entry name" value="CHEW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheW-like" evidence="1">
        <location>
            <begin position="15"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="167" mass="17651" checksum="5EC3DD9F37F2151A" modified="2014-10-29" version="1">MSAASTALAAAADGSSQILVFSLFEEGMSRRMDYGVEVGQVQEIGLLENISMVPNAPAYVKGVMNLRGKIITIIDVKQKLGFQAIKEVNAYTRILIVGVGSTLTGLLVDEVDEVIRISASNIEPNPASVAETSPYVKGIAKIQDRLVVILDLKMLLGEGNSGGSQAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUR1</accession>
    <name>A0A075MUR1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative methylthioribose-1-phosphate isomerase</fullName>
            <shortName evidence="2">M1Pi</shortName>
            <shortName evidence="2">MTR-1-P isomerase</shortName>
            <ecNumber evidence="2">5.3.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">MTNA-like protein</fullName>
            <shortName evidence="2">aMTNA</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">S-methyl-5-thioribose-1-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_00969</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>5-(methylsulfanyl)-alpha-D-ribose 1-phosphate = 5-(methylsulfanyl)-D-ribulose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:19989"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="ChEBI" id="CHEBI:58548"/>
            <dbReference type="EC" id="5.3.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.23" evidence="2"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987169.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUR1"/>
    <dbReference type="STRING" id="1459636.NTE_00969"/>
    <dbReference type="GeneID" id="41596799"/>
    <dbReference type="KEGG" id="nev:NTE_00969"/>
    <dbReference type="eggNOG" id="arCOG01123">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016218_1_2_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046523">
        <property type="term" value="F:S-methyl-5-thioribose-1-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.420:FF:000003">
        <property type="entry name" value="Methylthioribose-1-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Methylthioribose-1-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.420">
        <property type="entry name" value="translation initiation factor eif-2b, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01678">
        <property type="entry name" value="Salvage_MtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005251">
        <property type="entry name" value="IF-M1Pi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011559">
        <property type="entry name" value="Initiation_fac_2B_a/b/d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027363">
        <property type="entry name" value="M1Pi_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00524">
        <property type="entry name" value="eIF-2B_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004326">
        <property type="entry name" value="PRK05720.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00512">
        <property type="entry name" value="salvage_mtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43475">
        <property type="entry name" value="METHYLTHIORIBOSE-1-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43475:SF1">
        <property type="entry name" value="METHYLTHIORIBOSE-1-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="53"/>
            <end position="55"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="252"/>
            <end position="253"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="2">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF83044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="349" mass="37991" checksum="F2FB585CB58F24B1" modified="2014-10-29" version="1">MAKSKNLDLLLTVEWKDNAVVMIDQTKLPNKLAYVKCTDYHQVADAIKKLVVRGAPAIGVSAALGLALAAQNSKAKTLSELMTDLDTAFKELRATRPTAVNLFWALERVMGKAKRAKTLEDARNIVLAEAQKMWQEDVKANREMGANGARLFQDGDVVLTHCNAGSLATVAYGTALGVIRAARESGKRLSVIATETRPVMQGARLTAFELQHDGVDVSLIPDTAVGHMMARGAIKRVIVGADRVLRTGHVFNKIGTYQVAILASRHKVPFYVAAPLSTFDFESDPKDVVIEERSVDEVVKVGKKRVAPKGVRIFNPAFDMTPPELITGIITERGVLKPPFEKNLKALLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUV5</accession>
    <name>A0A075MUV5_9ARCH</name>
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        <submittedName>
            <fullName evidence="2">F5/8 type C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84452.1"/>
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    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F5/8 type C" evidence="1">
        <location>
            <begin position="38"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="579" mass="63007" checksum="904349489573CB54" modified="2014-10-29" version="1">MKQSLLLRLTIFALFAATLVILPPIATGAGKAVISASAAEEQVAHPSSSSPSCVALPIAKAEASGNEIGNVPSNVADGQPVTKWSFFGKGAWVSVDLGTLADICHVDVEWYRGNTRQSTFTISYSSDAATYTQLYSGKSSGNTSGFERYDFANVDARYVRITVNGNTQDDWSAIAEIKVYGDVSAVPDNTKPFIMVDQPANNSKVIASSSAASSDAATVSIRGKAEDFGSGVKIVEVRTDGTAYVPATPAASGDWSAWTHSLKLSSGAHNIVVRATDNAGNQQWHVSVVRVFQEPSSTVLAASPLKPKDRFGITQLYPSAAGGLEWSSKWDNGNARQFGNVVDPDDSWFETTHGIGNYTVDGNGTLTAAGNFTRMYVHDPANVREWSENLEITIYINRINETQLIDYSGLQIFARTNHGTNGNENRNFCDDRGYGVLVLTDGRWKLEKETAHHLSNGYVDLPGQKPWSELPKNTWVGIKFVLRNMDNDTKVKLELYRDMTGGLNGGRWEKMYEFIDNGTNFGAGYGACKPGVNPALPLVHSFIDPTSETRKPMLSVYARNEYGTMEYANFTIREINPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUY6</accession>
    <name>A0A075MUY6_9ARCH</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">NTE_02427</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701045.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUY6"/>
    <dbReference type="STRING" id="1459636.NTE_02427"/>
    <dbReference type="GeneID" id="41598136"/>
    <dbReference type="KEGG" id="nev:NTE_02427"/>
    <dbReference type="eggNOG" id="arCOG06357">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117488_0_0_2"/>
    <dbReference type="OrthoDB" id="11519at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="196" mass="20430" checksum="0D41F1958CA4E6DD" modified="2014-10-29" version="1">MLPQSSSAKGAMENGAKYGAIAGLIATWSISTAIAASELELGLPIGTFYAVMGTSLGAGGFGPAAYLGFGLHLLTGALLGAVIGLLMCRFFMIKFLNPYRAVAAGIGAGVGVWLVLFLPVTALLVQPSIARISFLLAESMPLQSAVLGNASQFVWGIALSAIAFHLVWGAIFGYTASAFLRIRAFRMTHPEKGMMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUZ2</accession>
    <name>A0A075MUZ2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02432</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701049.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUZ2"/>
    <dbReference type="STRING" id="1459636.NTE_02432"/>
    <dbReference type="GeneID" id="41598140"/>
    <dbReference type="KEGG" id="nev:NTE_02432"/>
    <dbReference type="HOGENOM" id="CLU_1092454_0_0_2"/>
    <dbReference type="OrthoDB" id="8351at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="257" mass="28794" checksum="C050B86E9CF74257" modified="2014-10-29" version="1">MAEGHAAPKHSVLAGAKTWFARHEQTLLIVNCVSIALLFLLHIFGSTVPVFAPALGSLVNVFAIVLVSFIFASVVWKGVVPAVICMLGVVLMHNAIILPYYPPADPTFPDFMVRSQDFSRSSAQVSAQVASTMHFILGLGMVALAITLAYRPGFLFTRNRPRQEEGDDDDIWSKYPIWYDNIKLVGDHKEPMAQAKSLMEDRDRYLIWRYEYVLAYIYGTAHLVRPDGLVPKKNTTFVRDEKSGLLVGKARHTGYFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUZ8</accession>
    <name>A0A075MUZ8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">50S ribosomal protein L40e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_02437</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701054.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUZ8"/>
    <dbReference type="STRING" id="1459636.NTE_02437"/>
    <dbReference type="GeneID" id="41598145"/>
    <dbReference type="KEGG" id="nev:NTE_02437"/>
    <dbReference type="eggNOG" id="arCOG04049">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_175093_1_0_2"/>
    <dbReference type="OrthoDB" id="45138at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023657">
        <property type="entry name" value="Ribosomal_eL40_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001975">
        <property type="entry name" value="Ribosomal_eL40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038587">
        <property type="entry name" value="Ribosomal_eL40_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003161">
        <property type="entry name" value="PRK04136.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39649">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L40E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39649:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01377">
        <property type="entry name" value="Ribosomal_L40e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL40" evidence="4">
        <location>
            <begin position="3"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF84487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="55" mass="6376" checksum="E7204CA1D6C292EB" modified="2014-10-29" version="1">MPIADATKKQIAQQRRLYFKICFHCGGKNPISATRCRKCHNDQMRLKNRTLGAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MV50</accession>
    <name>A0A075MV50_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">UvrABC system protein B</fullName>
            <shortName evidence="12">Protein UvrB</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Excinuclease ABC subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">uvrB</name>
        <name evidence="16" type="ORF">NTE_02483</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10 12">Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The beta-hairpin motif is involved in DNA binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the UvrB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MV50"/>
    <dbReference type="STRING" id="1459636.NTE_02483"/>
    <dbReference type="KEGG" id="nev:NTE_02483"/>
    <dbReference type="eggNOG" id="arCOG04748">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009621_2_1_2"/>
    <dbReference type="OrthoDB" id="8371at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120545">
        <property type="term" value="F:nucleic acid conformation isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd17916">
        <property type="entry name" value="DEXHc_UvrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18790">
        <property type="entry name" value="SF2_C_UvrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.10">
        <property type="entry name" value="UVR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00204">
        <property type="entry name" value="UvrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036876">
        <property type="entry name" value="UVR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004807">
        <property type="entry name" value="UvrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041471">
        <property type="entry name" value="UvrB_inter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024759">
        <property type="entry name" value="UvrB_YAD/RRR_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003673">
        <property type="entry name" value="PRK05298.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00631">
        <property type="entry name" value="uvrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24029">
        <property type="entry name" value="UVRABC SYSTEM PROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24029:SF0">
        <property type="entry name" value="UVRABC SYSTEM PROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12344">
        <property type="entry name" value="UvrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17757">
        <property type="entry name" value="UvrB_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46600">
        <property type="entry name" value="C-terminal UvrC-binding domain of UvrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 12" id="KW-0228">DNA excision</keyword>
    <keyword evidence="9 12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 12" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="37"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="437"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="13">
        <location>
            <begin position="623"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Beta-hairpin" evidence="12">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="50"/>
            <end position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00026033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AIF84532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="669" mass="76149" checksum="1D4BCF002B1FAAB9" modified="2014-10-29" version="1">MRELKIYCPLLSATGKFRLADVFAPSGDQPEAIEKLAKNAQKGGRQTLLGVTGSGKTFTIANVIAKTNKNTLVISHNKTLAAQLYAEFKEFFPENNVGYFVSFYDYYQPESYIPQTDTYIEKDTEVNEKIEKMRLEATAMLMSGEPTIIVATVSCIYSLGSPKEWESSSVALARGDIIDRKAIIKSLVDARYERNDLALVPGTFRAKGDTIDIIPGYSDDVIRVSMFGDEIEKISIHDYVSMKKLRDAGAVRIFPAKHYITAEDARQHAVRSIKSELQEWLPQLPSELEKQRLASRTKYDLEMIEELGYCSGIENYSRHFDGRKAGEPPFCLLDFFGDDFLLVIDESHVTLPQLHGMHNGDHTRKKSLVDFGFRLPSAYDNRPLKFEEFEKYLRNTVFVSATPGPYELKTSRQVVEQLVRPTGLVDPKVEVRPTKNQMEDLIREIKARAKRDQRTLVTTLTKRMAEDLAEFLAKNEVRVRYLHSEIEGLERTELIRQLRLGEFDVIVGINLLREGLDIPEVSLVAILDADKEGFLRNTTSLIQTFGRAARNLDGKVILYSDRMTESMKEAMEETERRRKRQLEYNKRHKITPRTIVKPVPESTAPGEVAEAAETKSMTRRDLQKLAIETEATMKKYAEELEFEKAIMFREKLAKIKKALGDVTPVTEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MV94</accession>
    <name>A0A075MV94_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATP-grasp superfamily enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03048</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MV94"/>
    <dbReference type="STRING" id="1459636.NTE_03048"/>
    <dbReference type="KEGG" id="nev:NTE_03048"/>
    <dbReference type="eggNOG" id="arCOG00347">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075000_0_0_2"/>
    <dbReference type="OrthoDB" id="35908at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10900">
        <property type="entry name" value="PAC-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019151">
        <property type="entry name" value="Proteasome_assmbl_chaperone_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038389">
        <property type="entry name" value="PSMG2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35610">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35610:SF3">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09754">
        <property type="entry name" value="PAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159659">
        <property type="entry name" value="Cgl1923-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="245" mass="26106" checksum="6F4CAB1D14F7B9E0" modified="2014-10-29" version="1">MAVPEIDIRKLKNVNLKGGIVVDGFPSVGLANAIASECLIHSLKTEFVAVIDSSAFPPLSIIKNAMPNFPARVYANEDLKLAMFVSELNLDPSMFRPVANMMIEWALDSNCDLIISAAGIPYEEGEGTKESPPVFAVGSTPAALKRAAEAGIPPVMNGSVSGIPAILLNEGAWRNYDVIVLMVKVVRDMPDFRAGAAVAEALAKLAPGASCDVPALLKEAEGMEKTLKRIRSEQQAALPKEPFYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVF7</accession>
    <name>A0A075MVF7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Small ribosomal subunit protein eS27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rps27e</name>
        <name evidence="6" type="ORF">NTE_03119</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the eukaryotic ribosomal protein eS27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701598.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVF7"/>
    <dbReference type="STRING" id="1459636.NTE_03119"/>
    <dbReference type="GeneID" id="41598779"/>
    <dbReference type="KEGG" id="nev:NTE_03119"/>
    <dbReference type="eggNOG" id="arCOG04108">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_199465_0_0_2"/>
    <dbReference type="OrthoDB" id="5718at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.100">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00371">
        <property type="entry name" value="Ribosomal_eS27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000592">
        <property type="entry name" value="Ribosomal_eS27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023407">
        <property type="entry name" value="Ribosomal_eS27_Zn-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001629">
        <property type="entry name" value="PRK00415.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01667">
        <property type="entry name" value="Ribosomal_S27e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="zinc finger region" description="C4-type" evidence="5">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF85153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="66" mass="7013" checksum="57EDF2365AD28C7F" modified="2014-10-29" version="1">MKRENILVPKPRSNFISVQCEKCGARTVIFSHTTSEIKCSGCGEILATSSGSKAVISGKVIGTLDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVI3</accession>
    <name>A0A075MVI3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Large ribosomal subunit protein eL24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">rpl24e</name>
        <name evidence="12" type="ORF">NTE_01202</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9 10">Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the eukaryotic ribosomal protein eL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700067.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVI3"/>
    <dbReference type="STRING" id="1459636.NTE_01202"/>
    <dbReference type="GeneID" id="41597011"/>
    <dbReference type="KEGG" id="nev:NTE_01202"/>
    <dbReference type="eggNOG" id="arCOG01950">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_190191_0_0_2"/>
    <dbReference type="OrthoDB" id="55506at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00472">
        <property type="entry name" value="Ribosomal_L24e_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.170.20:FF:000001">
        <property type="entry name" value="probable ribosome biogenesis protein RLP24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.20">
        <property type="entry name" value="Ribosomal protein L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00773">
        <property type="entry name" value="Ribosomal_eL24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038630">
        <property type="entry name" value="L24e/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056366">
        <property type="entry name" value="Ribosomal_eL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055345">
        <property type="entry name" value="Ribosomal_eL24-rel_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000988">
        <property type="entry name" value="Ribosomal_eL24-rel_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011017">
        <property type="entry name" value="TRASH_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF034186">
        <property type="entry name" value="PRK14891.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792:SF1">
        <property type="entry name" value="RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01246">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00746">
        <property type="entry name" value="TRASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 10 12" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 10" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TRASH" evidence="11">
        <location>
            <begin position="11"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="10">
        <location>
            <begin position="11"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00062681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIF83274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="70" mass="8110" checksum="F64AE45CDAA28FF9" modified="2014-10-29" version="1">MSKQATSLRNCFFCGRHITAGHGIMLVRNDGQVQWTCSSKCKKNLRLLKRDPRKLKWTSKYIKGGLRTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVM3</accession>
    <name>A0A075MVM3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nitrososphaera output domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700126.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVM3"/>
    <dbReference type="GeneID" id="41597075"/>
    <dbReference type="KEGG" id="nev:NTE_01270"/>
    <dbReference type="HOGENOM" id="CLU_160434_0_0_2"/>
    <dbReference type="OrthoDB" id="375752at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041226">
        <property type="entry name" value="NitrOD2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18550">
        <property type="entry name" value="NitrOD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitrososphaera output" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="105" mass="11679" checksum="B833A2882131E225" modified="2014-10-29" version="1">MVDVETLADAVFDSLKVIFGSTVFPALMEMIEEDYLGAEMDARTALVERPDLFERAFVGLLGESGKKILVDICEELCTRFLLDDKKATDLNTRDLAECMAIIPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVS7</accession>
    <name>A0A075MVS7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphomevalonate dehydratase large subunit</fullName>
            <ecNumber evidence="7">4.2.1.182</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NTE_02684</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of a hydro-lyase that catalyzes the dehydration of mevalonate 5-phosphate (MVA5P) to form trans-anhydromevalonate 5-phosphate (tAHMP). Involved in the archaeal mevalonate (MVA) pathway, which provides fundamental precursors for isoprenoid biosynthesis, such as isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(R)-5-phosphomevalonate = (2E)-3-methyl-5-phosphooxypent-2-enoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:78975"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58146"/>
            <dbReference type="ChEBI" id="CHEBI:229665"/>
            <dbReference type="EC" id="4.2.1.182"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:78976"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterodimer composed of a large subunit (PMDh-L) and a small subunit (PMDh-S).</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the AcnX type II large subunit family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.182" evidence="7"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVS7"/>
    <dbReference type="STRING" id="1459636.NTE_02684"/>
    <dbReference type="KEGG" id="nev:NTE_02684"/>
    <dbReference type="eggNOG" id="arCOG04278">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018825_1_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007506">
        <property type="entry name" value="PMDh-L-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36577">
        <property type="entry name" value="DUF521 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G00490)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36577:SF3">
        <property type="entry name" value="DUF521 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G00490)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04412">
        <property type="entry name" value="AcnX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="2 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphomevalonate dehydratase large subunit-like" evidence="9">
        <location>
            <begin position="17"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00045120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00045299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00046520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIF84727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="403" mass="43556" checksum="1B5D91615EF2CB23" modified="2014-10-29" version="1">MQEIWFLYSVYGDVFVELTREEERALAGEEGEALAMAYRILAAIGEATGAKRLVPIKWAHVSGVNYNTIGDAGVQFLEKFSEGARVAVKTTINPMGYDRSRPEQLPEKFIERQASIMRSYERMGVTPSFTCTPYEVFDIPKKGTAVSFAESNAAVFSNSLLGLRTNKESALSALASSVTGKAPLSDLRLDEARSPRVAIETKGLAFESDLDYGLLGYFAGKVVKDSSVALAGSIGSSIGRPQAKALSAGIGTSGSCGMFSLGDSIAGKEKIAFGKEEAKKARDELNTAEDGDIITLGSPQLGLEELATLAKMTEGKKFNKRCMIFCSRAIHNQATKIGLTGQIEKAGGEFMCDSCTCLTPYVDKDKYDSVVTSSVKAAYYMNNSNKVRVALKDIKTIVKEYTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVZ1</accession>
    <name>A0A075MVZ1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01404</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_075053487.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVZ1"/>
    <dbReference type="GeneID" id="41597198"/>
    <dbReference type="KEGG" id="nev:NTE_01404"/>
    <dbReference type="HOGENOM" id="CLU_2340013_0_0_2"/>
    <dbReference type="OrthoDB" id="7085at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="97" mass="11212" checksum="F59505B79CD16438" modified="2014-10-29" version="1">MAKRQFTIDTGKEQIPVEGHVHRNVAVKYLMKRRRSVLMTKNPEKVEKLFADLPTTIKIIGKQVTKEYKVNWQREGTEDTYAGSRFVFTMDEVGIPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVZ4</accession>
    <name>A0A075MVZ4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03397</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701838.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVZ4"/>
    <dbReference type="STRING" id="1459636.NTE_03397"/>
    <dbReference type="GeneID" id="41599043"/>
    <dbReference type="KEGG" id="nev:NTE_03397"/>
    <dbReference type="HOGENOM" id="CLU_2712616_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="72" mass="8207" checksum="E86915451590D1F1" modified="2014-10-29" version="1">MFSPAMIAKAKKAKELHKSVPAPLKVHEHIEDRPEGAGLYVFQALFAKKEDAERFMQLYQLSSDLEKYVEGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MW42</accession>
    <name>A0A075MW42_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glutamate-1-semialdehyde aminotransferase</fullName>
            <ecNumber evidence="7">5.4.3.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NTE_01450</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(S)-4-amino-5-oxopentanoate = 5-aminolevulinate</text>
            <dbReference type="Rhea" id="RHEA:14265"/>
            <dbReference type="ChEBI" id="CHEBI:57501"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="5.4.3.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Porphyrin-containing compound metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.3.8" evidence="7"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700274.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MW42"/>
    <dbReference type="STRING" id="1459636.NTE_01450"/>
    <dbReference type="GeneID" id="41597245"/>
    <dbReference type="KEGG" id="nev:NTE_01450"/>
    <dbReference type="eggNOG" id="arCOG00918">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_1_5_2"/>
    <dbReference type="OrthoDB" id="6524at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042286">
        <property type="term" value="F:glutamate-1-semialdehyde 2,1-aminomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43713">
        <property type="entry name" value="GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43713:SF3">
        <property type="entry name" value="GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE 1, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF83514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="452" mass="49264" checksum="AEF837F8F9C1F9F4" modified="2014-10-29" version="1">MNNDHYYYYESYIRRYKAKTGKSRRLYSRSEKLFPGGISHNIRYFEPYPFFVNAARGKTLFDVDGNKYTDYWMGHWALILGHSPPPVASALAKQAKNGTLYGVVNDVSVELAEAIQKLMPRAEMMRFSSTGSEATMYAVRLARAKTGRRVIAKAIGGWHGFNTTLMQTVNFPFEAEEGPGLVQDEGQYVESVPFNDLEASLKVLETIKDDLACVIIEPVLGGAGCIPPAKGYLEGLQEFCKKNGALFILDEIVTGFRLSLHGAQGTYGLEPDLFTLGKICGGGMPIGVVCGDKDIMSLADPVSIREKEARCAIGGGTFSANPATMAAGLATLDFLKKNERKVYGKVDRLGEMARKGLAKIFADAGVPCRVTGTNSIFLTHFVKEGTADVENATDVATSDKGKLVKYHTALMAEHGVFFLPTKMGAISYAHDEADVKKLLEATEKIASSGLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MW85</accession>
    <name>A0A075MW85_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02869</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MW85"/>
    <dbReference type="STRING" id="1459636.NTE_02869"/>
    <dbReference type="KEGG" id="nev:NTE_02869"/>
    <dbReference type="HOGENOM" id="CLU_2874907_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="63" mass="6685" checksum="1DB6E85B17B02917" modified="2014-10-29" version="1">MTMIDARRLAIRTKSIFQPLSQQEAAMNITRVPLLVILVVLAQHASIIMSSGGSSDGGHHGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWA4</accession>
    <name>A0A075MWA4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methylase involved in ubiquinone/menaquinone biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03502</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWA4"/>
    <dbReference type="STRING" id="1459636.NTE_03502"/>
    <dbReference type="KEGG" id="nev:NTE_03502"/>
    <dbReference type="eggNOG" id="arCOG03529">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037990_2_4_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF109">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="31"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="196" mass="21641" checksum="8D09A2593EFF1F43" modified="2014-10-29" version="1">MFTNAYAYDQFMGRWSRLLAPCLAQFAEIPNSGGKILDAGCGVGALAFAIAEFRPLCHVVGIDTSKEYVSYAESRNNYSDRVHFEIGDVQNLAFPDAAFDNSLSMLVLNFIPNAPRALSEMKRVTKPGGQVVAAVWDYGGVMEMLRVFWDAAVAVDSTASRLDERHMPLCRAGELSELCKSAALDNIHENSHWKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWC1</accession>
    <name>A0A075MWC1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Roadblock/LAMTOR2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01516</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWC1"/>
    <dbReference type="STRING" id="1459636.NTE_01516"/>
    <dbReference type="KEGG" id="nev:NTE_01516"/>
    <dbReference type="eggNOG" id="arCOG08684">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128582_1_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="152" mass="16919" checksum="B01257825BD814A0" modified="2014-10-29" version="1">MATRTKTSSKCTRTLTKPVGSPVHVQYDELCNRILELESSIRFVALADHLGLLIATVYRKGLVPLATKDETAKYAGQLVLLTGAVSGGKFMSKVGKMQYVVGKFENLVRATIPIVSDDYDKYYLLMSLDVDSDYVHVIDRVLAFLRENHSAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWE3</accession>
    <name>A0A075MWE3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="1">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_01536</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.2.1.8" evidence="1"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWE3"/>
    <dbReference type="STRING" id="1459636.NTE_01536"/>
    <dbReference type="KEGG" id="nev:NTE_01536"/>
    <dbReference type="eggNOG" id="arCOG04767">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_16_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00317">
        <property type="entry name" value="cyclophilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF4">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE DOMAIN AND WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="4">
        <location>
            <begin position="21"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF83599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="183" mass="19953" checksum="FBFB77E83372F463" modified="2014-10-29" version="1">MTFTLMQIQIPASGNHCRNNIMPTAKIQTKHGDIAIEFFPDVAPKHVENFKKLASSGFFDGTLFHRIVPGFVIQGGDPLTKNATNKGRWGTGGPGWNVKAEFNKTKHSRGVLSMARAMDPNSAGSQFFIVLKDSNFLDGQYTVFGKVTSGMDVVDKIAALKTDANDAPADPEQARMTKVTYSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWT8</accession>
    <name>A0A075MWT8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleotidyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701952.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWT8"/>
    <dbReference type="GeneID" id="41599171"/>
    <dbReference type="KEGG" id="nev:NTE_03555"/>
    <dbReference type="eggNOG" id="arCOG05472">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086890_0_0_2"/>
    <dbReference type="OrthoDB" id="109998at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="199" mass="23242" checksum="DF67B41AD876C0C6" modified="2014-10-29" version="1">MKIGMSGGKIKLNKELNDLDKLVLDFVKILDRNKVNYVLVSGYVSILFGRSRSSEDIDLIVEKISKKKFLALWKEISKGFDCITTDDPENAYRKYLAARAALRFSRTGEVIPNMEFKFPKVRLESWVLGNGMEVLLNRRAIRISPVELQIPYKLFLASEKDIEDARYLYRLFKEKLDQELLKYFLKKLDKEGAFNKYLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWV6</accession>
    <name>A0A075MWV6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative RNA-binding protein, contains TRAM domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_01688</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700464.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWV6"/>
    <dbReference type="STRING" id="1459636.NTE_01688"/>
    <dbReference type="GeneID" id="41597460"/>
    <dbReference type="KEGG" id="nev:NTE_01688"/>
    <dbReference type="eggNOG" id="arCOG01641">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_154338_1_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRAM" evidence="2">
        <location>
            <begin position="32"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF83749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="140" mass="14594" checksum="C0BD65A4B2E8B9B3" modified="2014-10-29" version="1">MSYGGRSNYGGSRGYGGGRGFGGDRGFGGPKPVETGKEYDVQISEISRQGDGIARIQGFVIFVKGGKVGQKAKVRITNVGARFATAEIVSEGQQQTPPSPTSSSSSSATTEEKPKDVAPQVGEEEKPTLQDYKGGSESQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MX83</accession>
    <name>A0A075MX83_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Haloacid dehalogenase superfamily enzyme, subfamily IA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03198</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701663.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MX83"/>
    <dbReference type="STRING" id="1459636.NTE_03198"/>
    <dbReference type="GeneID" id="41598855"/>
    <dbReference type="KEGG" id="nev:NTE_03198"/>
    <dbReference type="eggNOG" id="arCOG04692">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_876084_0_0_2"/>
    <dbReference type="OrthoDB" id="8384at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008967">
        <property type="term" value="F:phosphoglycolate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050155">
        <property type="entry name" value="HAD-like_hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43434">
        <property type="entry name" value="PHOSPHOGLYCOLATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43434:SF1">
        <property type="entry name" value="PHOSPHOGLYCOLATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="319" mass="35631" checksum="1A981A48B4B98097" modified="2014-10-29" version="1">MPGFDCALFDVDGVLVDIRKSYNEAIKKTVDFVLVQSGIKKMRGLVTDSLILKFRQSGGFNNDTDTSYAIALAVLASRQQQKTVTEARKFLLRVAENADETGIGSVERFLSAYDISKVKEMLAYPAPVKDSYIGRVFDELFYGPVLFKKQNGLVPKYCRDARPLIDNDRLAVSKKTMKTLHEKFDGNLAIVSGRSRLAAEYSLKPVMQYFDIDACVFLEDEKREYAKPNPYAAKKAMKAMGAKNAVYSGDSAEDMLMARRAQEETGLPIAFVGIYGYSPEPAKTLALFRERGAEAVAKSVDLLPKILYEQLSRKRDSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MXR2</accession>
    <name>A0A075MXR2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700728.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MXR2"/>
    <dbReference type="STRING" id="1459636.NTE_02027"/>
    <dbReference type="GeneID" id="41597770"/>
    <dbReference type="KEGG" id="nev:NTE_02027"/>
    <dbReference type="HOGENOM" id="CLU_2730551_0_0_2"/>
    <dbReference type="OrthoDB" id="377941at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="71" mass="8172" checksum="FFB3C4479C3E4F4A" modified="2014-10-29" version="1">MAEASNSKAEKIRKRKAAWAYIVGLFAVVFMWRSIWDWSDMYFSTMGSFIIGLILVGVVAVLQRDHVKDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MXZ0</accession>
    <name>A0A075MXZ0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1326 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03479</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701899.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MXZ0"/>
    <dbReference type="STRING" id="1459636.NTE_03479"/>
    <dbReference type="GeneID" id="41599109"/>
    <dbReference type="KEGG" id="nev:NTE_03479"/>
    <dbReference type="eggNOG" id="arCOG11393">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092801_0_0_2"/>
    <dbReference type="OrthoDB" id="6311at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009758">
        <property type="entry name" value="DUF1326"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014581">
        <property type="entry name" value="UCP033303"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07040">
        <property type="entry name" value="DUF1326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033303">
        <property type="entry name" value="UCP033303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="212" mass="23005" checksum="B3AF4571549758BE" modified="2014-10-29" version="1">MVDVPKWKVSGDWFDVCKCSIPCPCIFAQTPTYGDCEGVLAYHINNGNYGETPLDGLNALLVGGFKGNIWAGEATDSKMGFFFDERANEKQREALQMIFMGKAGGFMAELAKLFGKVTGVDFAPIKFEVAKDLAHWSAEIPGKVVAKVEALTGPMTPLGKRVQLYNAPGSETGPGTVATWGRALANEVDAMGFKFDWKGRSSKHIPFDWSGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MY20</accession>
    <name>A0A075MY20_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03524</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MY20"/>
    <dbReference type="KEGG" id="nev:NTE_03524"/>
    <dbReference type="HOGENOM" id="CLU_2613425_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="78" mass="8492" checksum="1ABCAB6F1E69B4E6" modified="2014-10-29" version="1">MLTDIPRGGAEGGEGCESGHIAEECIRLRYECCTEEREGKVAHTYTKAKVTNLRTSETKKLPLLLLSLSQKLGVAQDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MYE5</accession>
    <name>A0A075MYE5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">F420-0:gamma-glutamyl ligase</fullName>
            <ecNumber evidence="9">6.3.2.31</ecNumber>
            <ecNumber evidence="9">6.3.2.34</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NTE_02235</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.3.2.31" evidence="9"/>
    <dbReference type="EC" id="6.3.2.34" evidence="9"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226986947.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MYE5"/>
    <dbReference type="STRING" id="1459636.NTE_02235"/>
    <dbReference type="GeneID" id="41597955"/>
    <dbReference type="KEGG" id="nev:NTE_02235"/>
    <dbReference type="eggNOG" id="arCOG02714">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051152_1_1_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052618">
        <property type="term" value="F:coenzyme F420-0:L-glutamate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052619">
        <property type="term" value="F:coenzyme F420-1:gamma-L-glutamate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.100">
        <property type="entry name" value="CofE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1660.10">
        <property type="entry name" value="CofE-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008225">
        <property type="entry name" value="F420-0_g-glutamyl_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002847">
        <property type="entry name" value="F420-0_gamma-glut_ligase-dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01916">
        <property type="entry name" value="F420_cofE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009809">
        <property type="entry name" value="PRK13293.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47917">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47917:SF1">
        <property type="entry name" value="COENZYME F420:L-GLUTAMATE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01996">
        <property type="entry name" value="F420_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144010">
        <property type="entry name" value="CofE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Coenzyme F420:L-glutamate ligase-like" evidence="8">
        <location>
            <begin position="15"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF84289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="257" mass="28007" checksum="EAE8E92B868791A8" modified="2014-10-29" version="1">MPAIITVIPVKVNGDIAPKSDLGSTILESLGANGIELQDGDILVVAQKAVSKAEGRIIDLAKVKPSRKAIRLAKELHKDPRIVQLILDEAREIVTIKNGIIITETRHGFICANSGVDQSNLARDNAAILLPANPDSSARRLREFVKKQQNRNVAVVITDTFGRPFREGQTNIAVGVAGIKPIKNYIGKKDMFGRKLRVTEIAVADEIASAAELTMGKSAGIPVVLVRGYEFEHVSRASVKDLLRPKKQDIFRHTGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MYI8</accession>
    <name>A0A075MYI8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methylase involved in ubiquinone/menaquinone biosynthesis</fullName>
            <ecNumber evidence="1">2.1.1.163</ecNumber>
            <ecNumber evidence="1">2.1.1.201</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02281</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.163" evidence="1"/>
    <dbReference type="EC" id="2.1.1.201" evidence="1"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700928.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MYI8"/>
    <dbReference type="STRING" id="1459636.NTE_02281"/>
    <dbReference type="GeneID" id="41597996"/>
    <dbReference type="KEGG" id="nev:NTE_02281"/>
    <dbReference type="eggNOG" id="arCOG04348">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037990_9_0_2"/>
    <dbReference type="OrthoDB" id="1018at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008425">
        <property type="term" value="F:2-methoxy-6-polyprenyl-1,4-benzoquinol methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043770">
        <property type="term" value="F:demethylmenaquinone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF110">
        <property type="entry name" value="RHODANESE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01209">
        <property type="entry name" value="Ubie_methyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0830">Ubiquinone</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="226" mass="25267" checksum="278148F03A51D323" modified="2014-10-29" version="1">MLVQHKEGHATARKFFNSYTAPSYDLVVRTTTFGRDAAWKRRILAEIGVRKKVLDLACGTGILAAMVDTKVNRRVTGLDLTFEYLQVARKKMSLASVQATAEAIPYRDGAFDAIVSSYLAKYVDARALAGECWRVLAPGGVAVFHDFTCPENLAMYGLWKLYFAILRIAGVFARSWKEVFCDLDRVICDSCWTDKLVEALQERGFSDIECKRYTLGTAGMVVARKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MZ34</accession>
    <name>A0A075MZ34_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02465</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385466.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MZ34"/>
    <dbReference type="STRING" id="1459636.NTE_02465"/>
    <dbReference type="GeneID" id="43502646"/>
    <dbReference type="KEGG" id="nev:NTE_02465"/>
    <dbReference type="HOGENOM" id="CLU_3163259_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="47" mass="5680" checksum="715E32CBA4F908AA" modified="2014-10-29" version="1">MIDVCPVCYKFLQTIYDKKKMKEVRLAPDKECKSMYHKKLTDSFKTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MZX9</accession>
    <name>A0A075MZX9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YokE-like PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02758</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701311.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MZX9"/>
    <dbReference type="STRING" id="1459636.NTE_02758"/>
    <dbReference type="GeneID" id="41598447"/>
    <dbReference type="KEGG" id="nev:NTE_02758"/>
    <dbReference type="eggNOG" id="arCOG10590">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2203996_0_0_2"/>
    <dbReference type="OrthoDB" id="9104at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039519">
        <property type="entry name" value="YokE-like_PH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14470">
        <property type="entry name" value="bPH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YokE-like PH" evidence="1">
        <location>
            <begin position="8"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="104" mass="11902" checksum="B59C5BCC4CAE2D33" modified="2014-10-29" version="1">MSFEPQEGEKVLLREDCAEDRLKSGVLILTNKRILFQKTEGRMATFSKKEGEIILDIPLQAISAFRAEGFLVKKFVIVAVDQTYKFGVFSNSKWEKEMRQAKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N186</accession>
    <name>A0A075N186_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Short-chain alcohol dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_03190</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701655.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N186"/>
    <dbReference type="STRING" id="1459636.NTE_03190"/>
    <dbReference type="GeneID" id="41598846"/>
    <dbReference type="KEGG" id="nev:NTE_03190"/>
    <dbReference type="eggNOG" id="arCOG01259">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_9_2"/>
    <dbReference type="OrthoDB" id="10157at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF85219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="289" mass="31281" checksum="723C4CF8EB262313" modified="2014-10-29" version="1">MQKEGQEKKGNKVAVVSGSSSGIGLATSLALARNGFYTYATMRNLEKSAGIIDAAAKEKLPLQLVQLDVNDERSVNSAIAKITAEQGRIDVLVNNAGYGLFGALEDLSIEEIKAQYETNFFGLIRLTQAALPLMRKQNGGIIVNVGSVAGRIGFPGTAAYTSTKFALEGLTEAISYELEPFGIKVVIVEPGVIKTNFLNGMVVPRKTSDPNSPYLQLMQQMNATLSSMRENGSSSPEVVAKAVLQAVTVENPELRYLAGEDAVTLMEMRKKAPSDEEFRQMLKQNFSQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N1D9</accession>
    <name>A0A075N1D9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PPOX class probable F420-dependent enzyme, Rv2061 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_03255</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701715.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N1D9"/>
    <dbReference type="STRING" id="1459636.NTE_03255"/>
    <dbReference type="GeneID" id="41598910"/>
    <dbReference type="KEGG" id="nev:NTE_03255"/>
    <dbReference type="eggNOG" id="arCOG00516">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139738_0_0_2"/>
    <dbReference type="OrthoDB" id="6613at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070967">
        <property type="term" value="F:coenzyme F420 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052019">
        <property type="entry name" value="F420H2_bilvrd_red/Heme_oxyg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019965">
        <property type="entry name" value="PPOX_F420-dep_Rv2061_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03666">
        <property type="entry name" value="Rv2061_F420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35176">
        <property type="entry name" value="HEME OXYGENASE HI_0854-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35176:SF11">
        <property type="entry name" value="PYRIDOXAMINE 5'-PHOSPHATE OXIDASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="PNPOx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine 5'-phosphate oxidase N-terminal" evidence="2">
        <location>
            <begin position="8"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF85284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="127" mass="14049" checksum="5784B0B5042E78AE" modified="2014-10-29" version="1">MGPDLSQFEGQQCINLETYKKSGQPVATPVWFTIDGDRLFVVTRSETGKVKRLRNNEAVRIMPCGMRGEPKGEWLSAKARFATPEETEKALKQRSKKYGFKVKIAGLFSSGRGDLVAISIAPEEGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N267</accession>
    <name>A0A075N267_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase propeptide domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N267"/>
    <dbReference type="KEGG" id="nev:NTE_03511"/>
    <dbReference type="HOGENOM" id="CLU_1700203_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025711">
        <property type="entry name" value="PepSY"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03413">
        <property type="entry name" value="PepSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PepSY" evidence="1">
        <location>
            <begin position="69"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="154" mass="16212" checksum="ECC5395E02B123B4" modified="2014-10-29" version="1">MAGLSAATWKETIINTTSSNAYAQIATTEPDEKQAASSAVATVSTTGSVNATQAAIDFLNENLNPTLVDATDLAEDQVVNGTVIGGRLDVVQGHLVYNVTVVDSDNEVMYEVDIDPNTGRVLTTSAVGAPFGILFTTENDLMIEFLSQNLMQPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MKX0</accession>
    <name>A0A075MKX0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NTE_00007</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 12">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699163.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MKX0"/>
    <dbReference type="STRING" id="1459636.NTE_00007"/>
    <dbReference type="GeneID" id="41595961"/>
    <dbReference type="KEGG" id="nev:NTE_00007"/>
    <dbReference type="eggNOG" id="arCOG00329">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000203_6_2_2"/>
    <dbReference type="OrthoDB" id="8639at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050240">
        <property type="entry name" value="DNA_pol_type-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10322">
        <property type="entry name" value="DNA POLYMERASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10322:SF23">
        <property type="entry name" value="DNA POLYMERASE DELTA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="4 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="9">
        <location>
            <begin position="192"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="8">
        <location>
            <begin position="361"/>
            <end position="727"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIF82091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="749" mass="85813" checksum="7E093C65BC9BB382" modified="2014-10-29" version="1">MTVKGWLLDAYPSEDKMVFWVKQENGKTIRLESSWTPSIYVATDNKSDFSAILHDPELPSMVRAHEVVSRYERVIDREESKVLRLELSKSSVATRLAERIELLGPFGKFRLYNVDLLPAQSYLYEHELFPLAYCEVNPSSPVLKWDVLDDVWSTDYTVPDLKILNLDVSLRKEAKLPRFSDKVASITLAGKDGKKIMVEAKSEIEIFQALEREIARIDPDFILVQDGDSFVFPYLIHRAAENGVSLSLSRESTRLRKPKKEGTSYFSYGRIQFKPTAVKLRGRIHIDTRNSFTLDETGLHGLYEIARICRMPLHTASRASIGKCLSSLQFYHAHKKGLLVPWKPVLVEHFKTYGELLVADRGGFLFEPRTGVYEQAAEFDFASLYPSIMFQKNVSAETVRCPCCPDSKERVPELGYNICEKRRGIVPQALKIVIKKRAMYKELKKNATDDIQKAIYDERQSVLKWINVTSFGYLGFNNAKFGRIDAHIAVCAFDRQLFLQATRIAERMGFRVLHGIVDSLWLQKQNATMDDYAALKEAIECETGFSISFEGVYKWIVFFQSKESDELPAANRYFGAFQDGSLKIRGIEARRHDTPPLFVKFQHHILKIMARGDSIADVRLLMTEVRQVFDDYAAAIRDGRVSADDLVFTKQLSKDAGQYQERNTIENNSMSQLAREGKSLKAGQILRYVITDYYRDRHTTPEEFLDEKTQIDSKKYVEILAEMCNSVTEPFGLRIKPDDDKGGHHQLQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ML20</accession>
    <name>A0A075ML20_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00047</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ML20"/>
    <dbReference type="STRING" id="1459636.NTE_00047"/>
    <dbReference type="KEGG" id="nev:NTE_00047"/>
    <dbReference type="HOGENOM" id="CLU_2730136_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="71" mass="8094" checksum="BDA7E43F8F4E2246" modified="2014-10-29" version="1">MHMRYMQDFFAETIKPRLMALPAGHFFVGRGMRGKGRRVGVAAIQPQRPCYTAADNKKLPNIEYRQAIGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLX5</accession>
    <name>A0A075MLX5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-type multidrug transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NTE_00156</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987093.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLX5"/>
    <dbReference type="STRING" id="1459636.NTE_00156"/>
    <dbReference type="GeneID" id="41596094"/>
    <dbReference type="KEGG" id="nev:NTE_00156"/>
    <dbReference type="eggNOG" id="arCOG01467">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039483_2_3_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047817">
        <property type="entry name" value="ABC2_TM_bact-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051784">
        <property type="entry name" value="Nod_factor_ABC_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43229">
        <property type="entry name" value="NODULATION PROTEIN J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43229:SF2">
        <property type="entry name" value="NODULATION PROTEIN J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00164">
        <property type="entry name" value="ABC2TRNSPORT"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-2" evidence="6">
        <location>
            <begin position="39"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF82238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="270" mass="29836" checksum="17A45FA3968A338E" modified="2014-10-29" version="1">MMMNRNKNNSNNSNSVERFLYSSMTVAEMEARKLRHDSTELWTRVVQPALWLLIFGVTFNSLRALQTAGDFSYIQFITPGILAQSVLFIAIFYGITVVWERDVGIFTRLLSTPSPRASIVLGKALAAGLRGLFQAAMIFVLALLIGVEIRLDPVDVIGVFAIVVLFAMCFSSLSMLLASYMKTRDRMMGIGQALTMPLFFASNAIYPIALMPVWLQYVSLANPLSYVVDALRAMLITGNYANLPVDIAVVLFATVAFVALASVSIKRLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLY4</accession>
    <name>A0A075MLY4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00061</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLY4"/>
    <dbReference type="STRING" id="1459636.NTE_00061"/>
    <dbReference type="KEGG" id="nev:NTE_00061"/>
    <dbReference type="HOGENOM" id="CLU_127577_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="64"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="164" mass="18774" checksum="C18DB965EE208A45" modified="2014-10-29" version="1">MRSLIETLFLLKFLVNFLYEKNTCVITFFYHASTCVLIIMIKIEEMDENIKLDQQLEEKDYGGPVVFINVFNAKPQDVDKVLKAWAEDAAFFKQKPGLISTQLHRGIGESTVFVNYAIWESVAHMKQAVSDPAFRARLAHYPDGTVSRPHLFRKVAVPGICVEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MM52</accession>
    <name>A0A075MM52_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00251</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699337.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MM52"/>
    <dbReference type="STRING" id="1459636.NTE_00251"/>
    <dbReference type="GeneID" id="41596163"/>
    <dbReference type="KEGG" id="nev:NTE_00251"/>
    <dbReference type="eggNOG" id="arCOG03003">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_166867_0_0_2"/>
    <dbReference type="OrthoDB" id="189706at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06990">
        <property type="entry name" value="cupin_DUF861"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-2" evidence="1">
        <location>
            <begin position="60"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="111" mass="12426" checksum="BF3B7386DA201E1F" modified="2014-10-29" version="1">MEKKNIEQQPDQTVNMEKGKVQVANIGKLKVTKFTFEPGWTWEKCEKPLFNTDSCQLTHNGYIISGRLMVRMVDSGKEMEYGPGDTFYIPAGHDGYVVGNEPVVGLDISPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MM79</accession>
    <name>A0A075MM79_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MM79"/>
    <dbReference type="KEGG" id="nev:NTE_00510"/>
    <dbReference type="HOGENOM" id="CLU_2504797_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="85" mass="9475" checksum="9F2BB5386FADE57D" modified="2014-10-29" version="1">MRLRQEAEVMVATMETEAAEATEYSVHAMVVEEMGETVDTTMTMTMTTASIPASHTSPIQNIAKKMSGAKKHIHMHFLFLYLAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMC4</accession>
    <name>A0A075MMC4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Copper-containing nitrite reductase</fullName>
            <ecNumber evidence="3">1.7.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">NTE_00203</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>nitric oxide + Fe(III)-[cytochrome c] + H2O = Fe(II)-[cytochrome c] + nitrite + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15233"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.7.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Cu(+)</name>
            <dbReference type="ChEBI" id="CHEBI:49552"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotrimer.</text>
    </comment>
    <dbReference type="EC" id="1.7.2.1" evidence="3"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987097.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMC4"/>
    <dbReference type="STRING" id="1459636.NTE_00203"/>
    <dbReference type="GeneID" id="41596128"/>
    <dbReference type="KEGG" id="nev:NTE_00203"/>
    <dbReference type="eggNOG" id="arCOG02926">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG03914">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032707_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050421">
        <property type="term" value="F:nitrite reductase (NO-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd11024">
        <property type="entry name" value="CuRO_1_2DMCO_NIR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000923">
        <property type="entry name" value="BlueCu_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052721">
        <property type="entry name" value="ET_Amicyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001287">
        <property type="entry name" value="NO2-reductase_Cu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36507">
        <property type="entry name" value="BLL1555 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36507:SF1">
        <property type="entry name" value="BLL1555 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00127">
        <property type="entry name" value="Copper-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00695">
        <property type="entry name" value="CUNO2RDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 10" id="KW-0186">Copper</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="14">
        <location>
            <begin position="73"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="13">
        <location>
            <begin position="202"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Blue (type 1) copper" evidence="12">
        <location>
            <begin position="406"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="342"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="345"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="binding site" description="type 1 copper site" evidence="10">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="type 1 copper site" evidence="10">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="type 1 copper site" evidence="10">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="type 1 copper site" evidence="10">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="type 1 copper site" evidence="10">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="type 1 copper site" evidence="10">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601287-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AIF82285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="481" mass="52578" checksum="2D749C03A16B4B06" modified="2014-10-29" version="1">MKTTTKKFPMMTLAVAVAASIALTGVSGYFVLQPGNSEEILQNSAQGKGTADDDTSRGDAQKTVEYTLVGENTTLEIAPGVRVEAWTYNGTIPGPVLRATEGDRVVLHFINKTPMSHTIHLHGDHDEKDDGVFQVVKPGETYTYDFIAGPPGALMYHCHVMPVTQHIRMGLYGALIVDPKEGLSPAREYVLVAGEYDTKDQVTNNPEYVFFNGYADQYWDHPLEVKTNETVRVYYVNMGASPAYGFHIHGTIFDAYASGIWENTPMKVQTWEVAAGNGAIFEAKWPWEGRYLFHLHGLPEEKGTMAYFNVTNAPTSAVDGVDIAKTKSINMIGWQEDLARKLQKQDASGTPSVDASLSESPHGGHQMMDGVNGNNGKEANKKVEAGSAVPVQTNTVVMPKGAAADDSKSFEPSSITVNAGTTVTWRNDDNTFHIVASKAEGVFASDLISQKKTFEHTFAEQGTYDYYCSLHPWMTGTVNVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMN7</accession>
    <name>A0A075MMN7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Branched-chain-amino-acid aminotransferase</fullName>
            <shortName evidence="16">BCAT</shortName>
            <ecNumber evidence="16">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">ilvE</name>
        <name evidence="17" type="ORF">NTE_00018</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 16">Acts on leucine, isoleucine and valine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 16">
            <text>L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 16">
            <text>L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 16">
            <text>L-valine + 2-oxoglutarate = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 16">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 16">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 16">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 15">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="16"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699173.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMN7"/>
    <dbReference type="STRING" id="1459636.NTE_00018"/>
    <dbReference type="GeneID" id="41595972"/>
    <dbReference type="KEGG" id="nev:NTE_00018"/>
    <dbReference type="eggNOG" id="arCOG02297">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020844_3_1_2"/>
    <dbReference type="OrthoDB" id="6469at2157"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00058"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00073"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00062"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052656">
        <property type="term" value="F:L-isoleucine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052654">
        <property type="term" value="F:L-leucine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052655">
        <property type="term" value="F:L-valine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.10.10:FF:000002">
        <property type="entry name" value="D-alanine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005785">
        <property type="entry name" value="B_amino_transI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050571">
        <property type="entry name" value="Class-IV_PLP-Dep_Aminotrnsfr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01122">
        <property type="entry name" value="ilvE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005146">
        <property type="entry name" value="PRK06606.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42743">
        <property type="entry name" value="AMINO-ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42743:SF11">
        <property type="entry name" value="AMINODEOXYCHORISMATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 16 17" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="11 16" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="10 16" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 16 17" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU364094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AIF82102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="312" mass="34072" checksum="25FC1BC16FECC8D0" modified="2014-10-29" version="1">MTADEKGKIWLDGALVDHGDAKIHVLTHGLHYGTGVFEGIRCYKTVDGQSAIFRLQDHMQRLIDSGRIYFMDLGFTRKQLEQAAIDTVKANNMEECYIRPIAFYGYGKMGVNPMPNKVSVAIAVWKWDEYIKGSGEEKGARLMVSSWARLDPKTMPMHAKATANYANSALARVEAIKAGFDEAIMLNSSGMVVEASAENIFIVNKDGSLATPPTSSGALAGITRESVIAIAKENGIPCEERNISRDELYVADEVFLTGTAAEIKPVGEIDNRTIGRDGGRPGKVTKQLKTLFEAVVHGKDGKFSSKWLAPIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMW8</accession>
    <name>A0A075MMW8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00093</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699226.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMW8"/>
    <dbReference type="STRING" id="1459636.NTE_00093"/>
    <dbReference type="GeneID" id="41596038"/>
    <dbReference type="KEGG" id="nev:NTE_00093"/>
    <dbReference type="HOGENOM" id="CLU_951886_0_0_2"/>
    <dbReference type="OrthoDB" id="374652at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="292" mass="31606" checksum="5768E267E9F1F19F" modified="2014-10-29" version="1">MRNAAAIIIVIIISFAILAAADSSNSSALAYPLLPPWAQNPRNAGMGIVGMSMLSATSHNCNIELPAENPDNGGESVRFKIPQGVADIVSAGEPDKPANFHIAFEGDDGLYYEVGIYYGDWSRDSDIGYNATKFQVAWGIGGILRGVSNVPVIAGHTLELSILYGQSSTRQWQVWMDDLDDSKPVQVVNIGHPSMKVKSDYLTFVEAGSFAPNTNTQRLGLVEVLNIQHATRASNDDNSNNNKMDLSTWTSGYLLTDCSPVNSSYGVTYLGSTGKFKIGYEGETTKNGHKFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MN03</accession>
    <name>A0A075MN03_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 14">tRNA (cytidine(56)-2'-O)-methyltransferase</fullName>
            <ecNumber evidence="5 14">2.1.1.206</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 14">tRNA ribose 2'-O-methyltransferase aTrm56</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">NTE_00448</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 14">Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>cytidine(56) in tRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(56) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42968"/>
            <dbReference type="Rhea" id="RHEA-COMP:10308"/>
            <dbReference type="Rhea" id="RHEA-COMP:10309"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.206"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4 14">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the aTrm56 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.206" evidence="5 14"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699483.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MN03"/>
    <dbReference type="STRING" id="1459636.NTE_00448"/>
    <dbReference type="GeneID" id="41596324"/>
    <dbReference type="KEGG" id="nev:NTE_00448"/>
    <dbReference type="eggNOG" id="arCOG01857">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123709_0_0_2"/>
    <dbReference type="OrthoDB" id="14397at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106059">
        <property type="term" value="F:tRNA (cytidine(56)-2'-O)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002128">
        <property type="term" value="P:tRNA nucleoside ribose methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18083">
        <property type="entry name" value="aTrm56-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00077">
        <property type="entry name" value="tRNA_methyltr_aTrm56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002845">
        <property type="entry name" value="tRNA_mtfrase_aTrm56"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003048">
        <property type="entry name" value="PRK03958.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42197">
        <property type="entry name" value="TRNA (CYTIDINE(56)-2'-O)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42197:SF1">
        <property type="entry name" value="TRNA (CYTIDINE(56)-2'-O)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01994">
        <property type="entry name" value="Trm56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016123">
        <property type="entry name" value="UCP016123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 14" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="9 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="11 14" id="KW-0819">tRNA processing</keyword>
    <feature type="binding site" evidence="14">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="112"/>
            <end position="116"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="130"/>
            <end position="137"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AIF82530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="178" mass="20088" checksum="0D07DBE457233386" modified="2014-10-29" version="1">MKKKKQVMVLRIGHRLVRDDRVTTHAALVSRAFGAERIYMTGIDQSVKKTVDAVGKRWGGNFQMEIIEDWKGVARAWKKSGGKIAHLTMYGINIDDAVEKVRKEEKLLVIIGAEKVPREAYELADYNIAIGNQPHSEIAALAIFLDRVFEGKQFKKEVAGGQMRIVPSERGKQVEEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MN49</accession>
    <name>A0A075MN49_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00494</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699522.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MN49"/>
    <dbReference type="STRING" id="1459636.NTE_00494"/>
    <dbReference type="GeneID" id="41596367"/>
    <dbReference type="KEGG" id="nev:NTE_00494"/>
    <dbReference type="HOGENOM" id="CLU_1801610_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="143" mass="15191" checksum="C7AD90A8B721CFA6" modified="2014-10-29" version="1">MGKSVTWNITMSIEGAPTVAYSEGSNSPVEVDAVDVVSVKAKPATVAGGVTTPVVTTAKIQPGNLDQIKFMYIRLQEANLQGKITYKFKDGASESAEVTLDKDHFLTSNAVIQLFAQAPKEISFKNTEAAEGNIDVVVARMAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNC3</accession>
    <name>A0A075MNC3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative nucleic acid-binding protein, contains PIN domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_00225</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699319.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNC3"/>
    <dbReference type="STRING" id="1459636.NTE_00225"/>
    <dbReference type="GeneID" id="41596145"/>
    <dbReference type="KEGG" id="nev:NTE_00225"/>
    <dbReference type="eggNOG" id="arCOG00727">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121774_1_0_2"/>
    <dbReference type="OrthoDB" id="168412at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd09873">
        <property type="entry name" value="PIN_Pae0151-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044153">
        <property type="entry name" value="PIN_Pae0151-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051619">
        <property type="entry name" value="TypeII_TA_RNase_PINc/VapC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35901:SF1">
        <property type="entry name" value="EXONUCLEASE VAPC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35901">
        <property type="entry name" value="RIBONUCLEASE VAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIN" evidence="2">
        <location>
            <begin position="8"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF82307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="155" mass="17655" checksum="6C6B82FC1EC3CD82" modified="2014-10-29" version="1">MQQPDRFVLDASVAAKWFNNESLTDKAIEVRDAFVQGKIRLLAPAQMVYEVGNSIWKNKAWIAEAENAMNAISNLIDMEIESMQLNQEMAMDAMKIARDHSITFYDAAYIALADHFDATLISADDEILAKTKNKSRKENKEKPLMSIMHLKDFQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MP38</accession>
    <name>A0A075MP38_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Copper-containing nitrite reductase</fullName>
            <ecNumber evidence="3">1.7.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">NTE_00902</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>nitric oxide + Fe(III)-[cytochrome c] + H2O = Fe(II)-[cytochrome c] + nitrite + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15233"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.7.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Cu(+)</name>
            <dbReference type="ChEBI" id="CHEBI:49552"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotrimer.</text>
    </comment>
    <dbReference type="EC" id="1.7.2.1" evidence="3"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MP38"/>
    <dbReference type="STRING" id="1459636.NTE_00902"/>
    <dbReference type="KEGG" id="nev:NTE_00902"/>
    <dbReference type="eggNOG" id="arCOG02926">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG03914">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032707_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050421">
        <property type="term" value="F:nitrite reductase (NO-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd11024">
        <property type="entry name" value="CuRO_1_2DMCO_NIR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000923">
        <property type="entry name" value="BlueCu_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052721">
        <property type="entry name" value="ET_Amicyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001287">
        <property type="entry name" value="NO2-reductase_Cu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36507">
        <property type="entry name" value="BLL1555 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36507:SF1">
        <property type="entry name" value="BLL1555 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00127">
        <property type="entry name" value="Copper-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00695">
        <property type="entry name" value="CUNO2RDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 10" id="KW-0186">Copper</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="14">
        <location>
            <begin position="65"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="13">
        <location>
            <begin position="202"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="Blue (type 1) copper" evidence="12">
        <location>
            <begin position="401"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="349"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="binding site" description="type 1 copper site" evidence="10">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="type 1 copper site" evidence="10">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="type 1 copper site" evidence="10">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="type 1 copper site" evidence="10">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="type 1 copper site" evidence="10">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="type 1 copper site" evidence="10">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="type 1 copper site" evidence="10">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601287-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AIF82978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="471" mass="52706" checksum="D91B8616E58A63D6" modified="2014-10-29" version="1">MGITLSMVFVFIFETRFISQAQQQQQEQLSTVSPISSGAYITANDVYPKASNPNPQHREYTLIAQNAEIEVAKSVKAKVWTYNGTVPAPTLRFNEGDSVTVKFINKTPYSHTLHFHGSHNSANDGVIPQVLPGQQYVYNFTAEEAGLFMYHCHAFPTTEHVRMGMYGAMIIDPVHHPMQPAREYLFVLSELDPTNALANFTQFYPINGYADQYMEEPIRVVKNETARFYVIGIGGVLQSPFHIHSTLFKVWQSGILWNAPHWAQTHLVANGDTAIIEAKWDEPGRYLFHVHGIQEERGSMAFLDVLDNDTQLKALEKPSNMPQSKSMIEWQEQRIESLEKAKLTEYDNLGQASMPPSSMHSNHHGGSNNAEENAAGNVTAVKADAVTIVKGSSTPDITKPFVPAAVSVHEGTTVTWTNDDNAIHTVTEVNNIFDSGFVQAGAKWQHAFKEEGKFDYYCMLHPWMKGTVIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPE2</accession>
    <name>A0A075MPE2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00581</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPE2"/>
    <dbReference type="STRING" id="1459636.NTE_00581"/>
    <dbReference type="KEGG" id="nev:NTE_00581"/>
    <dbReference type="HOGENOM" id="CLU_3401502_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="30" mass="3435" checksum="970AFEB6C12E1B96" modified="2014-10-29" version="1">MIKSSGIMCNIDMFSDIFSPTLTIRVTERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPE5</accession>
    <name>A0A075MPE5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00939</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699868.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPE5"/>
    <dbReference type="GeneID" id="41596774"/>
    <dbReference type="KEGG" id="nev:NTE_00939"/>
    <dbReference type="HOGENOM" id="CLU_2021396_0_0_2"/>
    <dbReference type="OrthoDB" id="376812at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="122" mass="14049" checksum="C65124C23923F8DB" modified="2014-10-29" version="1">MYQYHLFPMLFIFILISFVALWDDMAFKLLGKHKRKKALLLGVANLVAAILIEDFAWFVNRWLMPLADDPKGGKLMQLTDWTSMHLGAIDLGSFVIPNWYLVALAIATLAYYGAFRKHDRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPG2</accession>
    <name>A0A075MPG2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transketolase, alpha subunit</fullName>
            <ecNumber evidence="5">2.2.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_00601</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transketolase family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.1" evidence="5"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699603.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPG2"/>
    <dbReference type="STRING" id="1459636.NTE_00601"/>
    <dbReference type="GeneID" id="41596464"/>
    <dbReference type="KEGG" id="nev:NTE_00601"/>
    <dbReference type="eggNOG" id="arCOG01051">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009227_1_1_2"/>
    <dbReference type="OrthoDB" id="6779at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004802">
        <property type="term" value="F:transketolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044272">
        <property type="term" value="P:sulfur compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07033">
        <property type="entry name" value="TPP_PYR_DXS_TK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000129">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051157">
        <property type="entry name" value="PDH/Transketolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43825">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43825:SF1">
        <property type="entry name" value="TRANSKETOLASE-LIKE PYRIMIDINE-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="4">
        <location>
            <begin position="10"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF82682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="326" mass="34474" checksum="BA322ECC4F9275BB" modified="2014-10-29" version="1">MLLSSEKKTADMRGAYGDALVELGKTDSRIVCVGGDTTDSLKTKKFGDKYPERMFNVGIAEANLVSIAAGLAIAGKVAFASTYAAFIPGRAVDQIRNAICYPALNVKLVVSHGGLTVGPDGASHQQIEDLSATRAMPNMRVTVPADAVAVRHLIKAMVDTPGPFYMRLARPTTELVYAESTPADQFRVGRGNVLVDGSDATIIACGLMVGKALEAASALKREEGISARVVDMFTIKPIDFDLVAKCAKETGAIATAEEHNIIGGLGGAVSEAAGETYPVPIKRVGVRDTFGESARDEEVDTLLDKYGLTATEIAKAVIEARSRIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPG3</accession>
    <name>A0A075MPG3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00955</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPG3"/>
    <dbReference type="STRING" id="1459636.NTE_00955"/>
    <dbReference type="KEGG" id="nev:NTE_00955"/>
    <dbReference type="HOGENOM" id="CLU_1830507_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="140" mass="16114" checksum="BFF52CCDB92AD56D" modified="2014-10-29" version="1">MAILSVLNQHKIWYNFDHQLLYLPEDKLGPDFILYPSGLKVEVKTGPADCNDLLINESQYKRWAKRNEIPDVILALSATSNDYVFEVKGWVKGNSANDKSRINKRLPSPAYSWPYDEINKIDDVADFLYSLSKYGLTRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPK6</accession>
    <name>A0A075MPK6_9ARCH</name>
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        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00662</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699651.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPK6"/>
    <dbReference type="STRING" id="1459636.NTE_00662"/>
    <dbReference type="GeneID" id="41596522"/>
    <dbReference type="KEGG" id="nev:NTE_00662"/>
    <dbReference type="eggNOG" id="arCOG01055">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_159725_1_2_2"/>
    <dbReference type="OrthoDB" id="4292at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038723">
        <property type="entry name" value="ArnR1-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14947">
        <property type="entry name" value="HTH_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ArnR1-like winged helix-turn-helix" evidence="1">
        <location>
            <begin position="6"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="97" mass="10965" checksum="0CB0007F9941056E" modified="2014-10-29" version="1">MPNNNRTHISIIADILDTARQYSYEGYDNGSGAPVTHLIRKANVPHRRLSSIVSDLKAYGLLDEAPDSKYRISEKGMEFLKSYNQFKGFAENFGLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPM6</accession>
    <name>A0A075MPM6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Monooxygenase subunit B protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987186.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPM6"/>
    <dbReference type="STRING" id="1459636.NTE_01090"/>
    <dbReference type="GeneID" id="41596906"/>
    <dbReference type="KEGG" id="nev:NTE_01090"/>
    <dbReference type="eggNOG" id="arCOG08675">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1431582_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.570">
        <property type="entry name" value="Particulate methane monooxygenase, b subunit. Chain: A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006833">
        <property type="entry name" value="NH3_CH4_mOase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023301">
        <property type="entry name" value="NH3_CH4_mOase_suB_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04744">
        <property type="entry name" value="Monooxygenase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="185" mass="20236" checksum="6F5A69998B0EAE56" modified="2014-10-29" version="1">MMESKTLVVTALATVMVLSAVIAYMPSASAHGVQAQLQSRFVRIDNEQFSDNTLQTGEELTVSGELKSLVNRDLRGWLSLFSESENAGNRWEFLARDPPGNIFDIKAGQTVPYSITVKALEPGTYHVHTQLNIEHIGPGLGRGQTVNVTGEPILKPIPYNNIVYQCIIIGAGLGITFATRPWQVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPP5</accession>
    <name>A0A075MPP5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00739</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699713.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPP5"/>
    <dbReference type="STRING" id="1459636.NTE_00739"/>
    <dbReference type="GeneID" id="41596591"/>
    <dbReference type="KEGG" id="nev:NTE_00739"/>
    <dbReference type="eggNOG" id="arCOG08684">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128582_0_1_2"/>
    <dbReference type="OrthoDB" id="7817at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="130" mass="14810" checksum="C1E803B260074A13" modified="2014-10-29" version="1">MSNRPQADPDTAAKYREKCNSILAISPRIRYAGVMNKFGRTLAGGLRKGVVPLLKPEEARNEYFIEATRSQLRKSFERSIGKTEYTFTENEKVKILTLTNEDNFYYLTMDKETPAAEVAKIIESAKKLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQ09</accession>
    <name>A0A075MQ09_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative metal-sulfur cluster biosynthetic enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_01588</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700383.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQ09"/>
    <dbReference type="STRING" id="1459636.NTE_01588"/>
    <dbReference type="GeneID" id="41597368"/>
    <dbReference type="KEGG" id="nev:NTE_01588"/>
    <dbReference type="eggNOG" id="arCOG01845">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091588_3_0_2"/>
    <dbReference type="OrthoDB" id="371709at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="entry name" value="Fe-S cluster assembly (FSCA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052339">
        <property type="entry name" value="Fe-S_Maturation_MIP18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42831">
        <property type="entry name" value="FE-S PROTEIN MATURATION AUXILIARY FACTOR YITW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42831:SF1">
        <property type="entry name" value="FE-S PROTEIN MATURATION AUXILIARY FACTOR YITW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="Fe-S cluster assembly (FSCA) domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIP18 family-like" evidence="2">
        <location>
            <begin position="25"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF83651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="123" mass="13533" checksum="E5B9EA9A2A9F1EC3" modified="2014-10-29" version="1">MSTDAKSDANSAPQKGNDDLQQTRRKIFDELTKIVDPEIGVSIMELELVDKVDINSGKVAIDLHLTSPFCPAVFGFKIAQDVRDNIYKLSGINDVKVQVSNHFMADAINKQVNESKYPAKPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQ17</accession>
    <name>A0A075MQ17_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01127</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987190.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQ17"/>
    <dbReference type="GeneID" id="41596941"/>
    <dbReference type="KEGG" id="nev:NTE_01127"/>
    <dbReference type="HOGENOM" id="CLU_103222_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="234" mass="25890" checksum="CB4499A3821E1AEC" modified="2014-10-29" version="1">MVVDKLFVAIIAAASLISIAVVAAFASEVLQSSSSSSPLLSSPAMQQNNKERVGFFASTNNNDNNNSSLIVDQKGDARPDQQYKTSIVPAVMGYHDILWADVRKTANGDDDGTFLLTAGLAGDPNLNEKYETTYVWHIMTSFNHVYTVILPNFAPDSGFAAKGWYFAVYNNTGQKYTVPMTRISFDMPRDRVEFPLEASLVGSPQSFHYWVSVHVRVDSQNLDKPPDYLMDYAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQ52</accession>
    <name>A0A075MQ52_9ARCH</name>
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        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01238</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700099.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQ52"/>
    <dbReference type="STRING" id="1459636.NTE_01238"/>
    <dbReference type="GeneID" id="41597046"/>
    <dbReference type="KEGG" id="nev:NTE_01238"/>
    <dbReference type="eggNOG" id="arCOG01117">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_170329_2_0_2"/>
    <dbReference type="OrthoDB" id="8136at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050684">
        <property type="entry name" value="HTH-Siroheme_Decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43413:SF6">
        <property type="entry name" value="REGULATORY PROTEIN ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43413">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR, ASNC FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription regulator AsnC/Lrp ligand binding" evidence="1">
        <location>
            <begin position="6"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="82" mass="8972" checksum="C85178618E4C2093" modified="2014-10-29" version="1">MPTGYILVNCTLGSEEKIINEIAKLPDVKEVRGTYGVHDIFVKVKSDNTESMNHVITNKIRKITGITSTVTLVVIEEQGGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQ56</accession>
    <name>A0A075MQ56_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700102.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQ56"/>
    <dbReference type="STRING" id="1459636.NTE_01243"/>
    <dbReference type="GeneID" id="41597049"/>
    <dbReference type="KEGG" id="nev:NTE_01243"/>
    <dbReference type="HOGENOM" id="CLU_1232713_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="224" mass="24846" checksum="3F41452C2E03872C" modified="2014-10-29" version="1">MEKEFSLVLPTADDLSGEPAPTKDEVYAKIAKEIEAVSPVVADTLTKVFAALNSKSRWHVYLATKKWSALHGVRLMDSGYIGLTHEFVHEDIAKPCDIILYGTPELLQSGEIIVSAIPLEQGGLKVLHHKVLSVGVQGGTAFVNTEDENKKQFTVPHDFIFGKILRVIEFEDKEWHELIGKLINEATLVAYLEKALAKYSGSKTPNKARVDEINRRLAILKGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQD9</accession>
    <name>A0A075MQD9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_01023</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQD9"/>
    <dbReference type="STRING" id="1459636.NTE_01023"/>
    <dbReference type="KEGG" id="nev:NTE_01023"/>
    <dbReference type="HOGENOM" id="CLU_2679073_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF83097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="77" mass="8053" checksum="F1A9CE9AD7709C76" modified="2014-10-29" version="1">MILSCSAESSTDKDKNFGQNAYDMAEEVFIFGVVTGVFAFLVGIVFAARARRYSQGYSSSSAVSAHGGSSSSSSHGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQI1</accession>
    <name>A0A075MQI1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative RNA-binding protein, contains TRAM domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_01414</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987210.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQI1"/>
    <dbReference type="STRING" id="1459636.NTE_01414"/>
    <dbReference type="GeneID" id="68225761"/>
    <dbReference type="KEGG" id="nev:NTE_01414"/>
    <dbReference type="eggNOG" id="arCOG01641">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_154338_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRAM" evidence="2">
        <location>
            <begin position="26"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF83478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="106" mass="10981" checksum="BE516893E20098EF" modified="2014-10-29" version="1">MEEKGSSSGSRGPRRFGGPRPFRLAPVSAGQEYDVTIESMSRRGDSGVAKIQGLVVFVAGTKAGDSVRIRITKVGSGFATAEVATDDDSSIESLSPDAEASADSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQI6</accession>
    <name>A0A075MQI6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phenylalanine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">NTE_01419</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="3"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700244.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQI6"/>
    <dbReference type="STRING" id="1459636.NTE_01419"/>
    <dbReference type="GeneID" id="41597213"/>
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        <property type="taxonomic scope" value="Archaea"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="F:tRNA binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00496">
        <property type="entry name" value="PheRS_alpha_core"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phenylalanine--tRNA ligase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.240">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Phe-tRNA-synth_IIc_asu"/>
    </dbReference>
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        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE ALPHA SUBUNIT"/>
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    </dbReference>
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        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="12">
        <location>
            <begin position="249"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006703"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AIF83483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="498" mass="55630" checksum="3E6DE646C669870C" modified="2014-10-29" version="1">MSSDAAALHPIERAILKALSGKEELSIEKLAEAASLSIDQARRGVEWLKFKNLASVNELSTFTVALDAAGTAAAQSGLPERRLVRAVKEGKTTMADVLTSGALKGDEVNAAVSGARRNQWIQFAEGNRMSATETAETQSAEEVLLARLQSSPDSIDSSALSEQEKKGLDLLKKRPKYVTIKEQKESRVSITETGRALLPAIESEKAQERRLTSELITSGKWKEVEFSALDVEAPAPAVYPGRSHPLVDIIEEVKEIFVGLGFSEIDGPMVQSGFWNFDALFTPQDHPAREMQDTFYISGERQEIPASKEQIAKVSGVHKQGWSGWNPEEAKRMVLRTHTTPVTLQHLAETKPEVARFFSVGRVFRNEKVSYKHLVEFHQVEGVATAPKASLRDLMGLQKEFYARMGIKKVKFWPTFFPYTEPSLQSMVYNDRLEKWVELFGMGIFRPEVTRPLGIKNPVLAWGGGLERIAMLRFGLDDVRDLYINRVSWLRSVPRCQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQL0</accession>
    <name>A0A075MQL0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01301</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="52" mass="5909" checksum="DEE7B953EB504C26" modified="2014-10-29" version="1">MALDVSSSGEDMDMVLLTPDEINRFILNLKMRYGGSSDQQYQKKKSVKTMHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQS0</accession>
    <name>A0A075MQS0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01134</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AIF83207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700017.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="41596948"/>
    <dbReference type="KEGG" id="nev:NTE_01134"/>
    <dbReference type="HOGENOM" id="CLU_2313649_0_0_2"/>
    <dbReference type="OrthoDB" id="12201at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="99" mass="11286" checksum="052AB5EAF25EC47B" modified="2014-10-29" version="1">MMKTQTDPWTMFLYSLKSPVPKVKYSHRLATFLAFAGLPSDIPEEEQARLFASKVASDMNWVFDVILKFVMYHLERMNRGRNSSGHGLAGIFISVLFAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQS7</accession>
    <name>A0A075MQS7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">50S ribosomal protein L3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NTE_01836</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700584.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQS7"/>
    <dbReference type="STRING" id="1459636.NTE_01836"/>
    <dbReference type="GeneID" id="41597600"/>
    <dbReference type="KEGG" id="nev:NTE_01836"/>
    <dbReference type="eggNOG" id="arCOG04070">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033361_2_0_2"/>
    <dbReference type="OrthoDB" id="6121at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.960.10">
        <property type="entry name" value="Ribosomal protein L3, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045077">
        <property type="entry name" value="L3_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044892">
        <property type="entry name" value="Ribosomal_L3_dom_3_arc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_uL3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019928">
        <property type="entry name" value="Ribosomal_uL3_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019926">
        <property type="entry name" value="Ribosomal_uL3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03626">
        <property type="entry name" value="L3_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003261">
        <property type="entry name" value="PRK04231.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11363">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11363:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00474">
        <property type="entry name" value="RIBOSOMAL_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="NCBIfam" id="TIGR03626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF83896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="334" mass="36762" checksum="7EF04CD4CEB58EAF" modified="2014-10-29" version="1">MGHRKYSAPRRGSIAFRPRARARSLEARVRTWPEIAGEKSSLLGFAGFKAGSIHVLTIDDREKTPNFGKQLLNAATVIATPPMKIIGARAYKTDLYGQHAIFDVYAKDLPKEMSRRVDIKQADDAMAKAEAKVAQASSVMAIAAVSPSAVGISQKKPFVFELAVSGKDAKAQFEYVKSILGKEMKASDIFQNGQNIDVFGITRGKGVEGPITRFGVKRKQHKSRKSVRAVGTLGPISPAVVMYTVARQGQRGFHQRTEYNKRILIMSNTEKDGQQQSSINPTGGFKHFGLVKGDYIVVRGSVPGVPKRLIKMRHPIRNLPKKVQEPKVLEVVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQU3</accession>
    <name>A0A075MQU3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQU3"/>
    <dbReference type="STRING" id="1459636.NTE_01515"/>
    <dbReference type="KEGG" id="nev:NTE_01515"/>
    <dbReference type="HOGENOM" id="CLU_2730139_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="71" mass="8325" checksum="3EB3A981862EDC3F" modified="2014-10-29" version="1">MKNEKRKKVNGAWRSCINDLLQPMPLKSRFSPFDAVLFFSCVRMPPSANLKYRVSALSSSYIMQFYYKKLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MR14</accession>
    <name>A0A075MR14_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Argininosuccinate lyase</fullName>
            <shortName evidence="1">ASAL</shortName>
            <ecNumber evidence="1 2">4.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Arginosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">argH</name>
        <name evidence="6" type="ORF">NTE_01585</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-(N(omega)-L-arginino)succinate = fumarate + L-arginine</text>
            <dbReference type="Rhea" id="RHEA:24020"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="EC" id="4.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.1" evidence="1 2"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385241.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MR14"/>
    <dbReference type="STRING" id="1459636.NTE_01585"/>
    <dbReference type="GeneID" id="41597365"/>
    <dbReference type="KEGG" id="nev:NTE_01585"/>
    <dbReference type="eggNOG" id="arCOG01748">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027272_2_3_2"/>
    <dbReference type="OrthoDB" id="27337at2157"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00114"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004056">
        <property type="term" value="F:argininosuccinate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:L-arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01359">
        <property type="entry name" value="Argininosuccinate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.200.10:FF:000015">
        <property type="entry name" value="argininosuccinate lyase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00006">
        <property type="entry name" value="Arg_succ_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029419">
        <property type="entry name" value="Arg_succ_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009049">
        <property type="entry name" value="Argininosuccinate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00838">
        <property type="entry name" value="argH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814">
        <property type="entry name" value="ARGININOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814:SF1">
        <property type="entry name" value="ARGININOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14698">
        <property type="entry name" value="ASL_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00145">
        <property type="entry name" value="ARGSUCLYASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarate lyase N-terminal" evidence="4">
        <location>
            <begin position="22"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Argininosuccinate lyase C-terminal" evidence="5">
        <location>
            <begin position="363"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="429"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="429"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="NCBIfam" id="TIGR00838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF83648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="491" mass="53727" checksum="12C66E5D25F159E2" modified="2014-10-29" version="1">MYRSRPKGRMDDDVLAFLSSTKHDQSILYYDIVGSEAHSVMLHEIGIISRQELKKILAALEAAKKNPGLIDTEGAEDIHEALEAFVIKQAGIDAGGKMHTARSRNDQVVLDIRMKVRDDINELCTALADLIDSLVKKAEKNKDAIMPLYTHLQQGQLGTFSHVMLAYADALCRDFERIYNTFGRINQSPLGSCAIAGTSIGIDRKRTATLLGFDGLMLNSLDATTSRDSFVEYVAALAILASTLARMAEDLIIWSTQEFGFVELDDRYSSTSSAMPQKKNPDPLELTRAKAAIIAGRLASMLGMVKGLPSGYSRDLQDIKPQLLEASATATSTVKVTNGVISTLTVKKKKMLDTSAKSYAISLDIAEQLVAKGVPFRSAHKVVGALVSRAAEKDIPLAALETKEISFALEQAKQNGIKPDELAKIVKEMTPEKSIESRRSAGSPNPKEQDEMIKTAKSRLAGYREGTQKRTKYVKDSLDILAKTVARYVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MR55</accession>
    <name>A0A075MR55_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Metal-dependent carboxypeptidase</fullName>
            <ecNumber evidence="1">3.4.17.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_01226</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of a C-terminal amino acid with broad specificity, except for -Pro.</text>
            <dbReference type="EC" id="3.4.17.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M32 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.17.19" evidence="1"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700088.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MR55"/>
    <dbReference type="STRING" id="1459636.NTE_01226"/>
    <dbReference type="GeneID" id="41597034"/>
    <dbReference type="KEGG" id="nev:NTE_01226"/>
    <dbReference type="eggNOG" id="arCOG04247">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032916_1_1_2"/>
    <dbReference type="OrthoDB" id="7244at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06460">
        <property type="entry name" value="M32_Taq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001333">
        <property type="entry name" value="Peptidase_M32_Taq"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34217:SF1">
        <property type="entry name" value="CARBOXYPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34217">
        <property type="entry name" value="METAL-DEPENDENT CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02074">
        <property type="entry name" value="Peptidase_M32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006615">
        <property type="entry name" value="Zn_crbxpep_Taq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00998">
        <property type="entry name" value="CRBOXYPTASET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52034">
        <property type="entry name" value="PEPTIDASE_M32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR006615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006615-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR006615-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF83297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="501" mass="58176" checksum="0CB5AC62B9277FD4" modified="2014-10-29" version="1">MKSENPVINQILDAYKPIWSINHATSLMGWDFETYMPRKGTEERGVADSQLRLLYKELLLDKDFVDLVELGKKQEGLNDAEKGIVRMLERNITKQIKIPKELTEAESLERIRGNMVWRQAREKSDFKMYEPYLKKMAEIKKQIAEKIGYEKHPYDALLDTFEEELTVADLDKVFGVLTPHIQKILKKLLDSGSPFCKEISKLGKPKYDIQKVDELNREILTLLQYDMERFRMDVSTHPFTQAMDLNDVRITTRYEGTDFKRSISSTIHEGGHALYDLQCDQSLSVTPVEGASSLALHESQSRFWENIVGRSKPFVQLIAPLIRRKVSFAGQATDDELYLYFNTVKPGYIRVDADEVTYNLHIAIRYEIEKKIIGDELTVSEIPEFWNDRMEQLLGVRPTDDSQGALQDTHWSSGLFGYFPTYTLGNLVSAIIASKMRKDLQDYEENIRNGDFRPVREWLRLKIHQHGSVYAPKTLLKNTFNEEGYNPDYFVKYIENKYFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRC0</accession>
    <name>A0A075MRC0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 6">Ornithine carbamoyltransferase</fullName>
            <shortName evidence="5">OTCase</shortName>
            <ecNumber evidence="2 5 6">2.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NTE_01293</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 5">
            <text>carbamoyl phosphate + L-ornithine = L-citrulline + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19513"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.3" evidence="2 5 6"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700147.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRC0"/>
    <dbReference type="STRING" id="1459636.NTE_01293"/>
    <dbReference type="GeneID" id="41597096"/>
    <dbReference type="KEGG" id="nev:NTE_01293"/>
    <dbReference type="eggNOG" id="arCOG00912">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043846_3_2_2"/>
    <dbReference type="OrthoDB" id="4696at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004585">
        <property type="term" value="F:ornithine carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019240">
        <property type="term" value="P:citrulline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:L-arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1370:FF:000008">
        <property type="entry name" value="Ornithine carbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="entry name" value="Aspartate/ornithine carbamoyltransferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01109">
        <property type="entry name" value="OTCase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002292">
        <property type="entry name" value="Orn/put_carbamltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024904">
        <property type="entry name" value="OTCase_ArgI"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00658">
        <property type="entry name" value="orni_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001986">
        <property type="entry name" value="PRK00779.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45753">
        <property type="entry name" value="ORNITHINE CARBAMOYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45753:SF3">
        <property type="entry name" value="ORNITHINE TRANSCARBAMYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00102">
        <property type="entry name" value="OTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="Aspartate/ornithine carbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aspartate/ornithine carbamoyltransferase carbamoyl-P binding" evidence="9">
        <location>
            <begin position="15"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Aspartate/ornithine carbamoyltransferase Asp/Orn-binding" evidence="8">
        <location>
            <begin position="161"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="64"/>
            <end position="67"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="142"/>
            <end position="145"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="241"/>
            <end position="242"/>
        </location>
        <ligand>
            <name>L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="278"/>
            <end position="279"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="NCBIfam" id="TIGR00658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIF83362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="321" mass="34688" checksum="F366BD9678D0FB35" modified="2014-10-29" version="1">MKTLKTSSNNNNNKRDLLGMQDLTAADIHAILKLAAKLKKEQKTGKARPLLRGKTLGMIFQKPSTRTRVSFEVGMNQLGGSAIYLGSTDIQLARGETIEDTAKTLSRYVDCLMARVYDHADVQKLAASASIPVINGLSDAFHPCQILADLLTIQEHKKKLEGLRMAWLGDGDNVCNDLLLGAAKTGISMAAACPAGYEPLEDVIKIAKAEGRKTGAEITITADPATAAKDADIIVTDTFISIGKEGERATREAVFLPEYQVNAGIMRLAKKDAIFMHCLPAKRGQEVSADVIDGPQSVVWDEAENRLHAQKAVLCMLMKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRG5</accession>
    <name>A0A075MRG5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRG5"/>
    <dbReference type="STRING" id="1459636.NTE_02085"/>
    <dbReference type="KEGG" id="nev:NTE_02085"/>
    <dbReference type="HOGENOM" id="CLU_2747968_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="70" mass="8133" checksum="B4214BD3279784D1" modified="2014-10-29" version="1">MIDNVFILKIEAGLYMLFDNSISPKYIISVSVYDASRQPESWQEPFLHNIAVAIATFKDILMNKCKYIHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRT3</accession>
    <name>A0A075MRT3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">Large ribosomal subunit protein eL37</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">rpl37e</name>
        <name evidence="12" type="ORF">NTE_02162</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the eukaryotic ribosomal protein eL37 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_075054179.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRT3"/>
    <dbReference type="STRING" id="1459636.NTE_02162"/>
    <dbReference type="GeneID" id="41597886"/>
    <dbReference type="KEGG" id="nev:NTE_02162"/>
    <dbReference type="eggNOG" id="arCOG04126">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_208825_0_0_2"/>
    <dbReference type="OrthoDB" id="5619at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00547">
        <property type="entry name" value="Ribosomal_eL37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001569">
        <property type="entry name" value="Ribosomal_eL37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_eL37/eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003214">
        <property type="entry name" value="PRK04179.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10768">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10768:SF0">
        <property type="entry name" value="RIBOSOMAL PROTEIN L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01907">
        <property type="entry name" value="Ribosomal_L37e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8 11 12" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="7 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 11" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="zinc finger region" description="C4-type" evidence="11">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00035225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIF84216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="56" mass="6760" checksum="538C9C495C6C4D85" modified="2014-10-29" version="1">MTKGTTSMGNFTRKKTHIRCRRCGHNSYHKRHKRCSKCGYPEATMRKYTWIKRQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRX1</accession>
    <name>A0A075MRX1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01858</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700602.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRX1"/>
    <dbReference type="STRING" id="1459636.NTE_01858"/>
    <dbReference type="GeneID" id="41597620"/>
    <dbReference type="KEGG" id="nev:NTE_01858"/>
    <dbReference type="HOGENOM" id="CLU_1280733_0_0_2"/>
    <dbReference type="OrthoDB" id="12340at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="215" mass="23189" checksum="47D8B383E4B94D01" modified="2014-10-29" version="1">MMNNKMKTTVIGVSIAAVAIAYVLSLQMAGLLSGSNTTTDEASATDKNVCKTDPSQIEVNFPIKQPDLASLPSGYSLKAVADFPNTVALYYADHEICPNLGLDNQVQERSIVELTGPIDWASSSEEMQRISLDNFSKDPGLQAHPQAIEVNGFKGYGWEPFEGASTYKINGTTVETTPAQMPGKVAWFDDNTKLGYSISGMESLSKLLEIAKTVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MS19</accession>
    <name>A0A075MS19_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Thiamine thiazole synthase</fullName>
            <ecNumber evidence="6">2.4.2.59</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">thi4</name>
        <name evidence="7" type="ORF">NTE_02257</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>hydrogen sulfide + glycine + NAD(+) = ADP-5-ethyl-4-methylthiazole-2-carboxylate + nicotinamide + 3 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:55704"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:139151"/>
            <dbReference type="EC" id="2.4.2.59"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homooctamer; tetramer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the THI4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.59" evidence="6"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700909.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MS19"/>
    <dbReference type="STRING" id="1459636.NTE_02257"/>
    <dbReference type="GeneID" id="41597973"/>
    <dbReference type="KEGG" id="nev:NTE_02257"/>
    <dbReference type="eggNOG" id="arCOG00574">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053727_2_0_2"/>
    <dbReference type="OrthoDB" id="4240at2157"/>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016763">
        <property type="term" value="F:pentosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052837">
        <property type="term" value="P:thiazole biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00304">
        <property type="entry name" value="Thi4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002922">
        <property type="entry name" value="Thi4_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022828">
        <property type="entry name" value="Thi4_prok"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00292">
        <property type="entry name" value="sulfide-dependent adenosine diphosphate thiazole synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43422">
        <property type="entry name" value="THIAMINE THIAZOLE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43422:SF3">
        <property type="entry name" value="THIAMINE THIAZOLE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01946">
        <property type="entry name" value="Thi4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="1 6" id="KW-0808">Transferase</keyword>
    <feature type="binding site" description="in other chain" evidence="6">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <note>ligand shared between two adjacent protomers</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="6">
        <location>
            <begin position="60"/>
            <end position="61"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <note>ligand shared between two adjacent protomers</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="6">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <note>ligand shared between two adjacent protomers</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>ligand shared between two adjacent protomers</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <note>ligand shared between two adjacent protomers</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="6">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>ligand shared between two adjacent protomers</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="6">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <note>ligand shared between two adjacent protomers</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>glycine</name>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF84311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="273" mass="29451" checksum="AE4381F4013E1967" modified="2014-10-29" version="1">MAKIFSDASEKEITRTIAQMFNETMNEFVDSDVIIIGAGPAGLTAGRDLAKAGVRTLIVEQNNYIGGGYWVGGYMMNPVTVRAPAQKLWDEIGVPYRKISDGLYATWGPHACSKLIASACDAGVRFLQLTKFDDLVLKNKRVAGVVVNWMPVSALPRNITCVDPVALESKLVIDASGHDSVAVKRLMDRGYVKWKGMDPMWVEGSEDNVVNFTGEVFPGLIAAGMSVTETHGLPRMGPTFGAMLFSGKKAAEVALGKLKEMPNPPKISSGGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MS25</accession>
    <name>A0A075MS25_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Short-chain alcohol dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_01850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700596.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MS25"/>
    <dbReference type="STRING" id="1459636.NTE_01850"/>
    <dbReference type="GeneID" id="41597614"/>
    <dbReference type="KEGG" id="nev:NTE_01850"/>
    <dbReference type="eggNOG" id="arCOG01259">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_461282_0_0_2"/>
    <dbReference type="OrthoDB" id="7442at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF133">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF83910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="598" mass="64481" checksum="CB2E7B3BE79C705B" modified="2014-10-29" version="1">MSGLKFDGKTVVVTGSGTGIGQAIAKRFAEAGANIVIMGRRKEPLDQTAEILNDIIKKAGSKGRVATFPGVDVSDEEGINTMFEGVKKQFGRVDIIVNNAGVSGPVKTFTNASIKEFRECVAIHLTGTFWTSAAGLKAMEKGGKIITISTFFSEENRYEQRPYRFRTPYTASQGAKNRLAECLAWELAERGIRSIATNPGPVHSDRIYKTVYPKAAAEFLRVGGYPGLSSTEVEVVTAKALPYLGDADDIVKKACRDAATEIAAKRGQPDEVTVSKLAETVAGALAKMQEIAEKIQGNTSKMIVDSEFLSQDEVAEMVLNLSDEKISKLINGRVIPNDRVFYPVKPIVGTGVDILPGSELKGKVIVLTTTSSAAKDVDRVKKIAGIAQVAGAKQVIVLYRNKADEAHFKEFHSHAIDFLDETAVRRIFNTAKTHFGPIDAVIHFTGDYDYNSAFSTMPRKQWEGLIDNFLYIPGMIVKESVIAMAPEGALAEPAKFKGTKGTVTLVGPDAPVGKKISGTLRARADVFRGALRPYTATTNQELGDVLGSNIKLHLVLAGNSEGAEPNADRLHASILSLAAGAALKRNEAIFYVDEARNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MS39</accession>
    <name>A0A075MS39_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01865</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385279.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MS39"/>
    <dbReference type="GeneID" id="43502622"/>
    <dbReference type="KEGG" id="nev:NTE_01865"/>
    <dbReference type="HOGENOM" id="CLU_2565543_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="81" mass="9130" checksum="C02F97D2241F6D5A" modified="2014-10-29" version="1">MDPRMEYALLDALGAISKIFGKEEEFEAFISYTRYAKTEGSNPSLEDIAMHTPGWIQLLAPPLRNLYNAGYESGRADYKPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MS43</accession>
    <name>A0A075MS43_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700612.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MS43"/>
    <dbReference type="STRING" id="1459636.NTE_01870"/>
    <dbReference type="GeneID" id="41597632"/>
    <dbReference type="KEGG" id="nev:NTE_01870"/>
    <dbReference type="HOGENOM" id="CLU_2152696_0_0_2"/>
    <dbReference type="OrthoDB" id="13618at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="112" mass="11483" checksum="18920891C6FDF074" modified="2014-10-29" version="1">MIGGPVKDVLAKIATAATAGMATILSTVRMAFAASTDASLPPEYTEMLRLAQEKVHAATQPGAFGNGVPLLFGADPMSLLLWIALAVSATMAAVCAGKILAPKMRSDPLLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MS69</accession>
    <name>A0A075MS69_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Plastocyanin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_01901</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MS69"/>
    <dbReference type="STRING" id="1459636.NTE_01901"/>
    <dbReference type="KEGG" id="nev:NTE_01901"/>
    <dbReference type="eggNOG" id="arCOG02926">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084115_4_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000923">
        <property type="entry name" value="BlueCu_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052721">
        <property type="entry name" value="ET_Amicyanin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36507">
        <property type="entry name" value="BLL1555 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36507:SF1">
        <property type="entry name" value="BLL1555 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00127">
        <property type="entry name" value="Copper-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Blue (type 1) copper" evidence="4">
        <location>
            <begin position="49"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="75"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF83960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="132" mass="13537" checksum="205C67BCD8C407EE" modified="2014-10-29" version="1">MNRKATMLAAGVAAILATAVLALAAGQQAAYAANVNIDIVSGASTKTNDAFSPNPGQAHVGDTVVWTNKDGAIHTVESGANGTPDGKFGVKPDKSPELIPPGKTLEFKPTEAGDFKYFCSLHPAMVGELKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MS99</accession>
    <name>A0A075MS99_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226986932.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MS99"/>
    <dbReference type="GeneID" id="41597728"/>
    <dbReference type="KEGG" id="nev:NTE_01980"/>
    <dbReference type="HOGENOM" id="CLU_114820_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="189" mass="21608" checksum="D1A2F75D35FA64B0" modified="2014-10-29" version="1">MMSRHMVSGKYFNKGVKALDAPHIGHVVRETADKIVVFGEGDDRYDIPKDKIRFAAANVLVDLPFYEVVKKYKVSRNEPLPTDQEHVHATDLPEPIDLATYEGKYPRSLFNKGVRTQDEEHVGHVMKETDDKVVIWGHYDWRFDVPKSKIIAVGRNIILGMDYKDVFKYKVDRDAPLPTGEPVEKIAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSA7</accession>
    <name>A0A075MSA7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700695.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSA7"/>
    <dbReference type="STRING" id="1459636.NTE_01985"/>
    <dbReference type="GeneID" id="41597733"/>
    <dbReference type="KEGG" id="nev:NTE_01985"/>
    <dbReference type="HOGENOM" id="CLU_1140598_0_0_2"/>
    <dbReference type="OrthoDB" id="11913at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="219" mass="23222" checksum="FBED9AFD646CF000" modified="2014-10-29" version="1">MNLTRGLAAKSLLFAAVLSVTTSVLATTASAVMTTTTLSLLPAAFAQQQTTTGNSTLSGIIASTQISNAGAPLWLSAGSWKLVTDKPIFGGNNQTQPTVKSFDATVDMVLLSNGTMFHTHHIYNFVQSGVLFQGNNVTAINGTMSVTTEKGTTENVPGYLHFQNNIMSIWVNPGKIDNHFGPTPINGMILSPEKLEELGAHLPQIQQNTTGSAQSNMTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSD3</accession>
    <name>A0A075MSD3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GMP synthase family protein</fullName>
            <ecNumber evidence="2">6.3.5.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01967</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.3.5.2" evidence="2"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700680.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSD3"/>
    <dbReference type="STRING" id="1459636.NTE_01967"/>
    <dbReference type="GeneID" id="41597715"/>
    <dbReference type="KEGG" id="nev:NTE_01967"/>
    <dbReference type="eggNOG" id="arCOG00087">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014340_1_4_2"/>
    <dbReference type="OrthoDB" id="10772at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003922">
        <property type="term" value="F:GMP synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044992">
        <property type="entry name" value="ChyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695:SF5">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="191" mass="21263" checksum="33F76529EAC191EF" modified="2014-10-29" version="1">MTSPLATLVVDNLSPFTPDILACLDKLGTTYVYRKYSEVTQDDLTTKCKRVILSGRRRNDQAINAANSQIVRHCHDNDVPLLGICYGAEIIALTLGGSIRRMPSHLHGQIEITATSPNPLVPAEKDSRISVYESHGFCIARLPEGFVRLAGSKYCEYEIFAHKTKKIYGTQFHPEKSGPDGLDLLEKFTRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSK4</accession>
    <name>A0A075MSK4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcription initiation factor IIB (TFIIB)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NTE_02053</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TFIIB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700747.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSK4"/>
    <dbReference type="STRING" id="1459636.NTE_02053"/>
    <dbReference type="GeneID" id="41597792"/>
    <dbReference type="KEGG" id="nev:NTE_02053"/>
    <dbReference type="eggNOG" id="arCOG01981">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043736_0_1_2"/>
    <dbReference type="OrthoDB" id="7429at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618:SF13">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="Zn_Ribbon_TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51134">
        <property type="entry name" value="ZF_TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIB-type" evidence="6">
        <location>
            <begin position="5"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF84110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="341" mass="37847" checksum="C51AD2571913539D" modified="2014-10-29" version="1">MTTSEYCTQCPECSANLIQDYSKGEFICERCGYVAMDSVYDFGRESNATDFEEKSKNTRASGSTSFALHDYGLRTEIASGSKDYAGKSIDYQMAEQMNNIRKWHIRSRIVSPQERRLSNVLTKINETCAAMSLPKLLVETAAMLYRNYESMQEAKGKSIACMAAATIYLACKKCRVVRSLDEIVAATGVTEQDRSSVKLASKYYRMMVMEMSAFAEEASSSPQATPEMPQQQQQVPVTMAIDHYISKLSNMAKIDTKVERLAIDIAHKTDDHMLADGKAPNGLAAAYIYVSSILLGINILQRDVSSLSGVTEVTIRNRCKDMLTGFKLTITVKPQTRPGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSN7</accession>
    <name>A0A075MSN7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycosyltransferase RgtA/B/C/D-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00282</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSN7"/>
    <dbReference type="KEGG" id="nev:NTE_00282"/>
    <dbReference type="HOGENOM" id="CLU_453903_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="345"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="369"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="393"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="440"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="497"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="525"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="572"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="599" mass="66718" checksum="4D7E1B1439DB1303" modified="2014-10-29" version="1">MSSIIASASLVVLCLFYVYSAATFAHLTVYPLIDRVTYYTVFGVYITNEYVDHVVLGSLLIVWLVVSLRKLKKIYYYIAIGIHAAFLVAGAAANYAVLLSGIALASLPVITALLLYNRYSLRKILKNQQQGLTLNYFGILGIILGIIGLAFATASVVSSNAVQSTQPVRNYAYDVFVVLSSFSPVFILLLIACIPVKLVTDSILRALKIRLTPLIIAENHKMRKMHRITYLLLIALSSIVFAVIPHLPTINPDNQKIGVDTGYYINWVTHLNESKDPQEFLYNAFVSQSEGDRPFTLILFSVFQKISNADLFLVVEYSSIILGPLLAISVYFLARELAANDLASLLAAFMTAISYPTLVGIYAGFYANWLALVFGYASFIFLLRFIKTIERKNLLLFALMILLTLLSHVYTWTIVTIVTGAYIAAIFVFKNKYTILNKSIVLIVIVILSVIAIDIVRVNITGSTGGIEKDLELAYRAIGVEQFALRWSNLNYTANSFVGGQLGNFIIYAFALYWLFKVRIESQTILLLIFLSIGLIPVLFGNYVIQTRVLYDIPFQIPAAIALSNINKKVNVISTLLFVIILFNISIIAVSNFYLVLPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSQ0</accession>
    <name>A0A075MSQ0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01746</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700509.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSQ0"/>
    <dbReference type="GeneID" id="41597516"/>
    <dbReference type="KEGG" id="nev:NTE_01746"/>
    <dbReference type="eggNOG" id="arCOG00485">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2433699_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="93" mass="10171" checksum="F27EBA820630BDBE" modified="2014-10-29" version="1">MTTNTTFLLETIKFSQDNLHTTLACSKCAEVFQKEFPLALEGLTSQFKCPICGAVGEADLPSKEGEEPEKLQEDLVVAETETEEGESGDQDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSR4</accession>
    <name>A0A075MSR4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_02572</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701156.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSR4"/>
    <dbReference type="STRING" id="1459636.NTE_02572"/>
    <dbReference type="GeneID" id="41598267"/>
    <dbReference type="KEGG" id="nev:NTE_02572"/>
    <dbReference type="eggNOG" id="arCOG05125">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086561_0_0_2"/>
    <dbReference type="OrthoDB" id="145577at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020209">
        <property type="entry name" value="Cas6b_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041528">
        <property type="entry name" value="Cas6b_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17262">
        <property type="entry name" value="Cas6b_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17955">
        <property type="entry name" value="Cas6b_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cas6b N-terminal" evidence="2">
        <location>
            <begin position="6"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Cas6b C-terminal" evidence="1">
        <location>
            <begin position="102"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF84616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="213" mass="24289" checksum="8A8B56634E77BBB7" modified="2014-10-29" version="1">MDKIKICYAYVEVPNNTISSVALRGFLGHLFVEDTEFHHHSESSYHYPLVQYKKVHGRLLVMGLNDYAEVVCRKISTLDHITTPTDKISIQSVDIVNDSFSIEETKSRFRFVTPWIALNEENYRKFKDLEGGKRKLFLEKILVGNILSALKGLSVFVNFKVTANLETFRPQSAKVHENYFQAFRASFSVNTNLPRFFGLGKSVSKGFGVIEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSU0</accession>
    <name>A0A075MSU0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Biotin synthase</fullName>
            <ecNumber evidence="4 13">2.8.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">bioB</name>
        <name evidence="16" type="ORF">NTE_01791</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(4R,5S)-dethiobiotin + (sulfur carrier)-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = (sulfur carrier)-H + biotin + 2 5'-deoxyadenosine + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:22060"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:149473"/>
            <dbReference type="EC" id="2.8.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
        <text evidence="13">Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="14">Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="13 14">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 13">Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 13">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the radical SAM superfamily. Biotin synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.6" evidence="4 13"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700548.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSU0"/>
    <dbReference type="STRING" id="1459636.NTE_01791"/>
    <dbReference type="GeneID" id="41597557"/>
    <dbReference type="KEGG" id="nev:NTE_01791"/>
    <dbReference type="eggNOG" id="arCOG00658">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033172_2_1_2"/>
    <dbReference type="OrthoDB" id="9264at2157"/>
    <dbReference type="UniPathway" id="UPA00078">
        <property type="reaction ID" value="UER00162"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004076">
        <property type="term" value="F:biotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000026">
        <property type="entry name" value="Biotin synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01694">
        <property type="entry name" value="BioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010722">
        <property type="entry name" value="BATS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002684">
        <property type="entry name" value="Biotin_synth/BioAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024177">
        <property type="entry name" value="Biotin_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00433">
        <property type="entry name" value="bioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22976">
        <property type="entry name" value="BIOTIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22976:SF2">
        <property type="entry name" value="BIOTIN SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06968">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001619">
        <property type="entry name" value="Biotin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01060">
        <property type="entry name" value="BATS_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01278">
        <property type="entry name" value="biotin_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00876">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13 14" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5 13 14" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10 13" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="11 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12 13 14" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13 14" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 13 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="15">
        <location>
            <begin position="47"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001619-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AIF83852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="325" mass="35496" checksum="08F17B86964BDD95" modified="2014-10-29" version="1">MSDAPFIKACMDKVLAGGRITIDEAERLLATDDVMALADCANTITRKFNGDVVDVEALINAKSGKCPEDCSFCAQSTFYETGINKYPLLPKETIVEQAEMAKAGGATNFCLVCAYRSPPEKDFEQICETITAIKEQVGTEVNVSLGFMTLERARRLKQLGVKRYNHNLEASESYFSKICTTHDFRDRVNTAKIVKEAGLELCCGGIIGMGETPRQRLELAFSIASLDPDEVPMNILIGREGTPFAGYKDLIEPMDAIKAIAVWRFIMPKTILKIAGGREVHLKDKDRLALKAGANGIITGGYLTTGGNAPNKDITMIKEIGLKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MT46</accession>
    <name>A0A075MT46_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Precorrin-4 C11-methyltransferase</fullName>
            <ecNumber evidence="8">2.1.1.133</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NTE_00412</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.133" evidence="8"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699454.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MT46"/>
    <dbReference type="STRING" id="1459636.NTE_00412"/>
    <dbReference type="GeneID" id="41596292"/>
    <dbReference type="KEGG" id="nev:NTE_00412"/>
    <dbReference type="eggNOG" id="arCOG00645">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011276_7_1_2"/>
    <dbReference type="OrthoDB" id="6633at2157"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046026">
        <property type="term" value="F:precorrin-4 C11-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11641">
        <property type="entry name" value="Precorrin-4_C11-MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="entry name" value="Cobalt-precorrin-4 Transmethylase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="entry name" value="Methyltransferase, Cobalt-precorrin-4 Transmethylase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006362">
        <property type="entry name" value="Cbl_synth_CobM/CibF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050161">
        <property type="entry name" value="Siro_Cobalamin_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003043">
        <property type="entry name" value="Uropor_MeTrfase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01465">
        <property type="entry name" value="cobM_cbiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45790:SF4">
        <property type="entry name" value="COBALT-PRECORRIN-4 C(11)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45790">
        <property type="entry name" value="SIROHEME SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="Tetrapyrrole methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00839">
        <property type="entry name" value="SUMT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="4 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tetrapyrrole methylase" evidence="7">
        <location>
            <begin position="7"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF82494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="270" mass="29612" checksum="8B5818355BDEEB0F" modified="2014-10-29" version="1">MQGDKKTVYFVGSGPGDPELITLKAKRLVEQADVIIYSGSLFNPKNLEYARKDAELHDAALIDREKIYQILRDSALAGKLAVRFHDGDPALFSTIREQIDKLEADGIACKVVPGVTAILGAAADLKLELTLPGITQTLIITRAELRTPVPEREAISELAKHGATMAFYLSVHLIGDVVKELLKGGVYTEQTPAAVVYRATWEDEKIIKGTLGDIAEKTKKERIIKTALIIVGDVIAPKKYEHAKVYDAGFTHGYRKAEEGSNKQKLQTTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MT61</accession>
    <name>A0A075MT61_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribulose-5-phosphate 4-epimerase-like epimerase or aldolase</fullName>
            <ecNumber evidence="4">4.1.2.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_01933</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.1.2.17" evidence="4"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700653.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MT61"/>
    <dbReference type="STRING" id="1459636.NTE_01933"/>
    <dbReference type="GeneID" id="41597682"/>
    <dbReference type="KEGG" id="nev:NTE_01933"/>
    <dbReference type="eggNOG" id="arCOG04226">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006033_3_4_2"/>
    <dbReference type="OrthoDB" id="18709at2157"/>
    <dbReference type="UniPathway" id="UPA00071"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008738">
        <property type="term" value="F:L-fuculose-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019323">
        <property type="term" value="P:pentose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050197">
        <property type="entry name" value="Aldolase_class_II_sugar_metab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22789:SF0">
        <property type="entry name" value="3-OXO-TETRONATE 4-PHOSPHATE DECARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22789">
        <property type="entry name" value="FUCULOSE PHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="3">
        <location>
            <begin position="4"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF83992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="193" mass="21034" checksum="141C0C6AAF1288A3" modified="2014-10-29" version="1">MTKSELARCVRDLYSLGLTSPVSGNHSVRAGNRSMWITPSEIPRYLLHTSDLVRMDLSTGRAFGKKKPSREHNMHRMIYDARRDVNAVVHTHSPYTIAVAISAGEGFVHVIEEAKIVVGNPAIIENRPSGSIELAEAVSAEFEKGASAVVIRNHGVVAAGKDIHHARAIVESLEEWAKILTVARLLGGPRSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MT68</accession>
    <name>A0A075MT68_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nitrososphaera output domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700910.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MT68"/>
    <dbReference type="GeneID" id="41597974"/>
    <dbReference type="KEGG" id="nev:NTE_02259"/>
    <dbReference type="HOGENOM" id="CLU_160434_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041226">
        <property type="entry name" value="NitrOD2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18550">
        <property type="entry name" value="NitrOD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitrososphaera output" evidence="1">
        <location>
            <begin position="20"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="119" mass="13327" checksum="1FDDDE3DD2728EA0" modified="2014-10-29" version="1">MLVPDTIDGDIIMALRPRQEAIADAVLSGLKETFGWSVYDLLIKKITQNYLNNKIDIRTAIVEHPAVFERAFIGLIGPLGEKFLADVCEKVQSELDLDHYATYSRVGDFAKYIMIASHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTA4</accession>
    <name>A0A075MTA4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rhodanese-related sulfurtransferase</fullName>
            <ecNumber evidence="3">2.8.1.1</ecNumber>
            <ecNumber evidence="3">2.8.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_02295</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.8.1.1" evidence="3"/>
    <dbReference type="EC" id="2.8.1.2" evidence="3"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148702128.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTA4"/>
    <dbReference type="STRING" id="1459636.NTE_02295"/>
    <dbReference type="GeneID" id="41598010"/>
    <dbReference type="KEGG" id="nev:NTE_02295"/>
    <dbReference type="eggNOG" id="arCOG02019">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031618_1_7_2"/>
    <dbReference type="OrthoDB" id="10492at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016784">
        <property type="term" value="F:3-mercaptopyruvate sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01448">
        <property type="entry name" value="TST_Repeat_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01449">
        <property type="entry name" value="TST_Repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051126">
        <property type="entry name" value="Thiosulfate_sulfurtransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001307">
        <property type="entry name" value="Thiosulphate_STrfase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43855">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43855:SF1">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00380">
        <property type="entry name" value="RHODANESE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="17"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="155"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF84348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="265" mass="29571" checksum="3B2A3220040635B8" modified="2014-10-29" version="1">MLVISPEELNARITRKKDKSLLIIDARPFSDYAEGHVPGAVNIDLMQFHWIDTSKEGIRQFNKQTRILLSNIGVSKDKFVVFYDDVSGPSAARGVWLLLYFSHSNVAMLDGGLAAWKAKGFPLEEKTNPFVHSKFEGRPDPKILAGYGTIKSAIKKKKTIVLDARSKEEFDGTAVRAARAGHIPKAINIDWNDNIKDSAFKGTDDLAKMYSQIPKDAEVITYCQGGYRAANSFVVLKMLGYKNVKMYLGSWGEWGNRPDLPVVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTJ6</accession>
    <name>A0A075MTJ6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Urea amidohydrolase (Urease) gamma subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02908</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701432.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTJ6"/>
    <dbReference type="STRING" id="1459636.NTE_02908"/>
    <dbReference type="GeneID" id="41598586"/>
    <dbReference type="KEGG" id="nev:NTE_02908"/>
    <dbReference type="HOGENOM" id="CLU_1943956_0_0_2"/>
    <dbReference type="OrthoDB" id="10299at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.280.10">
        <property type="entry name" value="Urease, gamma-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002026">
        <property type="entry name" value="Urease_gamma/gamma-beta_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036463">
        <property type="entry name" value="Urease_gamma_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00547">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54111">
        <property type="entry name" value="Urease, gamma-subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="132" mass="14782" checksum="1E75D39DBCB33521" modified="2014-10-29" version="1">MIYIKAVAKGEPDAAPLAKFFQYIDSTDELILKHSIEMVKDKMDRNLKLNVNEAFLLYAYFVATQVRAKKKAAEIEKDANSLLSSDQVMIGVPETLRTITFDAIVDGKREWITLQEPMSVSSYVMANNSSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTP1</accession>
    <name>A0A075MTP1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NTE_02506</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701109.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTP1"/>
    <dbReference type="STRING" id="1459636.NTE_02506"/>
    <dbReference type="GeneID" id="41598210"/>
    <dbReference type="KEGG" id="nev:NTE_02506"/>
    <dbReference type="eggNOG" id="arCOG01390">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038143_0_0_2"/>
    <dbReference type="OrthoDB" id="46222at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00761">
        <property type="entry name" value="Glyco_tranf_GTA_type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43646">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43646:SF2">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 2-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="7">
        <location>
            <begin position="67"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF84555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="422" mass="46560" checksum="42D2CE3CF6442446" modified="2014-10-29" version="1">MEPAALDVAIAAVNFTLAAIFAGILGVWVYFLTYMTKSFRLAPRMDDYHYYPLAPANGGSDSKPKVSVILPARNEEKYIARCLDTLLAQDYPNFEVIAINDNSTDRTGEIIQSYAVRDRRIVYVSTPAKPEGWAGKNWACHQGYKKASGEYLFFTDADTEHAPDVMSLAVGRMLSEGLDALTAIPRLLCNDFWTKVTLPALSTFLHTRFSPLRVNDPKHKTGYFFGSFFVITKKTYEAVGTHEGVRQELVEDGALGNKVKAAGFRMKMVRGEKHVEAIWARDFTTLWHGLRRLVIPLYHQDHTGAHLIAVAVFFIMFAPFLFLGYTVPAFFALAANSGGLGGLSATILLGVHVATILMLLATTAVQSKLGVMQSPAYALGSPLSGALIYLGFASAIVDARKKGAVSWRDRQYTVSEKQNFLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTP9</accession>
    <name>A0A075MTP9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02469</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701078.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTP9"/>
    <dbReference type="STRING" id="1459636.NTE_02469"/>
    <dbReference type="GeneID" id="41598175"/>
    <dbReference type="KEGG" id="nev:NTE_02469"/>
    <dbReference type="HOGENOM" id="CLU_2044303_0_0_2"/>
    <dbReference type="OrthoDB" id="8924at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="120" mass="13335" checksum="4BFA4790E1EAC702" modified="2014-10-29" version="1">MSGGEDDKRVEEAASAIEDLLYMGAIRLDGDRALLSPQFSLVASNVTDSMKVKADSPEEVMKLMYYSLLIFMNEYLKMPKALTMAFGNDMENHRDATESGALVTTYVAILSEIWSQNKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTT6</accession>
    <name>A0A075MTT6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTT6"/>
    <dbReference type="STRING" id="1459636.NTE_03001"/>
    <dbReference type="KEGG" id="nev:NTE_03001"/>
    <dbReference type="HOGENOM" id="CLU_2856920_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="64" mass="7312" checksum="375CEA7FB5619C77" modified="2014-10-29" version="1">MTMSHKISCRACGEYLSPTAICTVCQEYVIWTCPRCERIDDVTHIHGYCRVAYKKIEIVKAKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTW0</accession>
    <name>A0A075MTW0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative Zn-dependent protease-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NTE_02581</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase U62 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTW0"/>
    <dbReference type="STRING" id="1459636.NTE_02581"/>
    <dbReference type="KEGG" id="nev:NTE_02581"/>
    <dbReference type="eggNOG" id="arCOG00321">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026425_1_2_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2290.10">
        <property type="entry name" value="PmbA/TldD superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045569">
        <property type="entry name" value="Metalloprtase-TldD/E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045570">
        <property type="entry name" value="Metalloprtase-TldD/E_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002510">
        <property type="entry name" value="Metalloprtase-TldD/E_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051463">
        <property type="entry name" value="Peptidase_U62_metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025502">
        <property type="entry name" value="TldD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035068">
        <property type="entry name" value="TldD/PmbA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036059">
        <property type="entry name" value="TldD/PmbA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30624:SF0">
        <property type="entry name" value="METALLOPROTEASE SLR0863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30624">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN TLDD AND PMBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01523">
        <property type="entry name" value="PmbA_TldD_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19290">
        <property type="entry name" value="PmbA_TldD_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19289">
        <property type="entry name" value="PmbA_TldD_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004919">
        <property type="entry name" value="TldD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111283">
        <property type="entry name" value="Putative modulator of DNA gyrase, PmbA/TldD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metalloprotease TldD/E N-terminal" evidence="5">
        <location>
            <begin position="30"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Metalloprotease TldD/E central" evidence="7">
        <location>
            <begin position="126"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Metalloprotease TldD/E C-terminal" evidence="6">
        <location>
            <begin position="241"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF19289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF19290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF84625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="475" mass="50876" checksum="ACBC1D547F230B04" modified="2014-10-29" version="1">MLLQQQPQAVLDMLRSLVSSSSSSRGTSYVEARYQARSFSEVNFANGRLERVRMVENAGCGIRVLVDGCWGFSSSASMSKEDLKESLVQAVSMARVLGRSKKNKVKGLAESKMARGTFVAKAKGDLAGIDIEQKVRVAREAEAAARKHAKGIKTASATYRDMLDHKVIANSDGAEVEIFDSKPEFNVTAVAREGAKSVTASEGIGITGGWDDLFKKGHLEYAQVAAEKAAKLLQAKYATGEKTTIILDPGMVGLLCHEAIGHTVEADFVLSGSVVKDKIGQKVASDLVTLVDSGRSDIAENAAGTIGVDDEGVEAGRTAIIEKGILKSFLHNRESAFAFGTASTGNARAFTYTDEPLIRMRNTYIEPRADTLDEIVKETKHGYLVKGARNGQADANGEFMFGAQEAYLIENGEVKELMRGASISGNAFDVLRSIDMVGSKFEYDIGTGYCGKYQPAKVDGGGPHVRCTAIIGGMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTW9</accession>
    <name>A0A075MTW9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02546</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTW9"/>
    <dbReference type="KEGG" id="nev:NTE_02546"/>
    <dbReference type="HOGENOM" id="CLU_2597526_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="79" mass="9154" checksum="85163E093F344898" modified="2014-10-29" version="1">MKSVVKKKLHTFLAEEYALIVRKCYGRNLNELPDMVRNLPFESQIPGSNPGRSTFSCFHTYIASNQKEQIQNYRSSIKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTZ8</accession>
    <name>A0A075MTZ8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding TFAR19-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03107</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PDCD5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701589.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTZ8"/>
    <dbReference type="STRING" id="1459636.NTE_03107"/>
    <dbReference type="GeneID" id="41598767"/>
    <dbReference type="KEGG" id="nev:NTE_03107"/>
    <dbReference type="eggNOG" id="arCOG04179">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122978_3_1_2"/>
    <dbReference type="OrthoDB" id="7912at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.140">
        <property type="entry name" value="PDCD5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002836">
        <property type="entry name" value="PDCD5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036883">
        <property type="entry name" value="PDCD5-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10840">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10840:SF0">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01984">
        <property type="entry name" value="dsDNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015730">
        <property type="entry name" value="TFAR19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46950">
        <property type="entry name" value="Double-stranded DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="96" mass="10965" checksum="073B2568CA1636E5" modified="2014-10-29" version="1">MSAPPPQQPNDEEIRRREAEAAAMRQRVLSVVLDPQARQRLTNIRLVKPDLATAVENYLINAASTGRLNRALSDDELKQILASLQQPKKEFKFDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MU03</accession>
    <name>A0A075MU03_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_03112</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_075055409.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MU03"/>
    <dbReference type="STRING" id="1459636.NTE_03112"/>
    <dbReference type="GeneID" id="41598772"/>
    <dbReference type="KEGG" id="nev:NTE_03112"/>
    <dbReference type="eggNOG" id="arCOG01580">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091233_5_4_2"/>
    <dbReference type="OrthoDB" id="6995at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043200">
        <property type="term" value="P:response to amino acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30154">
        <property type="entry name" value="LEUCINE-RESPONSIVE REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30154:SF34">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR AZLB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13412">
        <property type="entry name" value="HTH_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="4"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF85146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="154" mass="17402" checksum="FD0F4C5196B08BA1" modified="2014-10-29" version="1">MGKIDDLDVKILSELAKDASISVPKLSKKININSSVVYSRIKRLVKKGLIKKFTIVINDEALGFNVKALTGINMDSKLRDNVLNELFKIPEVREVSEVTGRFDILVTMNAHSLDEMHQLISEKIGRVEGVQKTETFIEMRKTVRELAYPSSIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MU07</accession>
    <name>A0A075MU07_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 19 20">Adenosylcobinamide-GDP ribazoletransferase</fullName>
            <ecNumber evidence="5 19 20">2.7.8.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16 19">Cobalamin synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15 19">Cobalamin-5'-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">cobS</name>
        <name evidence="21" type="ORF">NTE_03117</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14 19">Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17 19">
            <text>alpha-ribazole + adenosylcob(III)inamide-GDP = adenosylcob(III)alamin + GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16049"/>
            <dbReference type="ChEBI" id="CHEBI:10329"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="EC" id="2.7.8.26"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18 19">
            <text>alpha-ribazole 5'-phosphate + adenosylcob(III)inamide-GDP = adenosylcob(III)alamin 5'-phosphate + GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23560"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57918"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="ChEBI" id="CHEBI:60493"/>
            <dbReference type="EC" id="2.7.8.26"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 19">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 19">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 7/7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 19">Cell membrane</location>
            <topology evidence="2 19">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 19">Belongs to the CobS family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.26" evidence="5 19 20"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385611.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MU07"/>
    <dbReference type="STRING" id="1459636.NTE_03117"/>
    <dbReference type="GeneID" id="41598777"/>
    <dbReference type="KEGG" id="nev:NTE_03117"/>
    <dbReference type="eggNOG" id="arCOG04338">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057426_2_0_2"/>
    <dbReference type="OrthoDB" id="11748at2157"/>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00238"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051073">
        <property type="term" value="F:adenosylcobinamide-GDP ribazoletransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008818">
        <property type="term" value="F:cobalamin 5'-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00719">
        <property type="entry name" value="CobS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003805">
        <property type="entry name" value="CobS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00317">
        <property type="entry name" value="cobS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34148">
        <property type="entry name" value="ADENOSYLCOBINAMIDE-GDP RIBAZOLETRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34148:SF1">
        <property type="entry name" value="ADENOSYLCOBINAMIDE-GDP RIBAZOLETRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02654">
        <property type="entry name" value="CobS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 19" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 19" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="11 19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 19 21" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="182"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="NCBIfam" id="TIGR00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="AIF85151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="256" mass="26476" checksum="6CAE243F5A717B4A" modified="2014-10-29" version="1">MASLKPVQSVLAFLTIIPVGKKDGDHDIHYIAKNMYLFPVAGAIVGIMAGGMAFGISPFLPPLLVGLLVAGALVILTGVHHTDALADFADGMMAKGDKEKKRKAMMDPAVGSAGVAALVMYFAGMIIVFNTGFSGGIKILTSIIAAEVIAKYIMVLLTYRGTSAWEGFSSPFTAAMKDGKKMLAATAIMLPIVWFSTGYAGMAALGVSVALGALVRHAAKRSFGGISGDVLGASNEVARLASLIVLSSLPPVVMTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MU17</accession>
    <name>A0A075MU17_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NTP pyrophosphohydrolase MazG putative catalytic core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03127</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701606.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MU17"/>
    <dbReference type="STRING" id="1459636.NTE_03127"/>
    <dbReference type="GeneID" id="41598787"/>
    <dbReference type="KEGG" id="nev:NTE_03127"/>
    <dbReference type="eggNOG" id="arCOG01084">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2519881_0_0_2"/>
    <dbReference type="OrthoDB" id="8377at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101386">
        <property type="entry name" value="all-alpha NTP pyrophosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="85" mass="9475" checksum="FF4F924243360349" modified="2014-10-29" version="1">MSATTAAVEYYNIKFGDNAQAAFVHLVREIGEIAFAMEKQNAEHAKLEITESIALLHYLASKYNLDVPANMQALYSKKLEGLRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MU25</accession>
    <name>A0A075MU25_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02615</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MU25"/>
    <dbReference type="KEGG" id="nev:NTE_02615"/>
    <dbReference type="HOGENOM" id="CLU_2103384_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="115" mass="13331" checksum="C0846F8F8448E8D1" modified="2014-10-29" version="1">MMGHGEKIIWLFGLLVSFGGQTFLKPLSICSFLLYESFGLHSKRRLVGQMPLELDRNWSLYIYVDGVCVMETVLRYQFLNALPILYGFTPETLYGRCHFYCKVVHIPCRRESGLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MU40</accession>
    <name>A0A075MU40_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acetylornithine/succinylornithine aminotransferase</fullName>
            <ecNumber evidence="8">2.6.1.11</ecNumber>
            <ecNumber evidence="8">2.6.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NTE_00736</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.11" evidence="8"/>
    <dbReference type="EC" id="2.6.1.17" evidence="8"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699712.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MU40"/>
    <dbReference type="STRING" id="1459636.NTE_00736"/>
    <dbReference type="GeneID" id="41596588"/>
    <dbReference type="KEGG" id="nev:NTE_00736"/>
    <dbReference type="eggNOG" id="arCOG00914">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_10_0_2"/>
    <dbReference type="OrthoDB" id="85346at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003992">
        <property type="term" value="F:N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009016">
        <property type="term" value="F:succinyldiaminopimelate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000004">
        <property type="entry name" value="Acetylornithine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004636">
        <property type="entry name" value="AcOrn/SuccOrn_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050103">
        <property type="entry name" value="Class-III_PLP-dep_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00707">
        <property type="entry name" value="argD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986:SF79">
        <property type="entry name" value="ACETYLORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986">
        <property type="entry name" value="AMINOTRANSFERASE CLASS III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF82814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="393" mass="43027" checksum="43CEDBF554AB5F0B" modified="2014-10-29" version="1">MNGEDNYLGTLYQRFPVNVARGKGARIWDVNGKEYIDCMGGYGVALVGHCNDRVVDAIKRQAETLITAHMSVYNETRLEFMKKMAQVAPPGLAKMFFTNSGAESVEAALKFARKFTGKHGVIAMNGAYHGKTFGALSVTYNEKYRKAFMPLLDGVKFVPYGEPSKLEDSIDDTTGAVILEPIQGETGIIVPPDDLIPKIREICNRRNLVLIFDEIQAGLGRTGKMWAGQNWNTTPDIMCLAKGIAGGVPMGLVLTKPEIMDAIKLGEHSSTFGASPLACAAASATLEALTTDGLVDNAAKTGKIFKEKLIALKERHKIIREVRGLGMMLGVELRFEVKDVLFDGISNGLLMLYSGRNIIRLLPPLVMDEATVSRAVEIMDAVLTREEQRRNVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MU78</accession>
    <name>A0A075MU78_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00806</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MU78"/>
    <dbReference type="KEGG" id="nev:NTE_00806"/>
    <dbReference type="HOGENOM" id="CLU_812853_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="345" mass="38287" checksum="602687486D536585" modified="2014-10-29" version="1">MPITVFSVAKSCRGHVQNWHESLLLASVYCHIVDNDMLKGIKNILGMTNAGTTDSRTPPPATPPSGRTGPTDRFGLAKLNPTKAGGIEWYSKFDNGHVRKLASGIDPDDPWLDLSHGEGKYEINGSGRLTATGHYVRIYVVSPDHKREWDENLEITGVLTRIREFGPAKDSYIQVYCRTNHGIDYDEDKLLNDNRGYGAVFLYDGTWSFEKETAHHLDNGYAPAHNTDKFPLGNVFPKNTPVPFKYVIRNNAANTQTTVELWLGNKDSADGSPWTMVTSFTDTGNNWGVGHDSCSSGVDPAIRLTRSLVLPSCISKKPFLSVYLRNEEGTVAYEKLSIREIDPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MU84</accession>
    <name>A0A075MU84_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02218</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MU84"/>
    <dbReference type="KEGG" id="nev:NTE_02218"/>
    <dbReference type="eggNOG" id="arCOG08805">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100103_1_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="Ribbon-helix-helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="195" mass="22768" checksum="151B8DD044D22A56" modified="2014-10-29" version="1">MRNNTFINNTNTHMVMGSLHGKTETIAFRLDTSMIERLRNEAKQKEISLNALAGQIFKQHIDWHSNAAKAGFLTVRRGLIVKLLELATDSELVKIAEYIAKKETKNFVLMLRNEYNITSVLDVVETWIRIAGYPYRHEVNYSKHFYTIQHDMGKKWSLYISNQYQFMFEDFGLKKVDFEITDSVISFTVDTENMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUA0</accession>
    <name>A0A075MUA0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00838</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUA0"/>
    <dbReference type="KEGG" id="nev:NTE_00838"/>
    <dbReference type="HOGENOM" id="CLU_2802411_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="67" mass="7805" checksum="BE16B9BD490044C9" modified="2014-10-29" version="1">MNIVAQLIVESYQNATVNTILEDIGRKYKIDTKRDCLQVDSPIEEIKFKYRTYGECVRMLYKKAGVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUJ6</accession>
    <name>A0A075MUJ6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA-guanine(15) transglycosylase</fullName>
            <ecNumber evidence="6">2.4.2.48</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">7-cyano-7-deazaguanine tRNA-ribosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Archaeal tRNA-guanine transglycosylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tgtA</name>
        <name evidence="8" type="ORF">NTE_03307</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>guanosine(15) in tRNA + 7-cyano-7-carbaguanine = 7-cyano-7-carbaguanosine(15) in tRNA + guanine</text>
            <dbReference type="Rhea" id="RHEA:43164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10371"/>
            <dbReference type="Rhea" id="RHEA-COMP:10372"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:45075"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:82850"/>
            <dbReference type="EC" id="2.4.2.48"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">tRNA modification; archaeosine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the archaeosine tRNA-ribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.48" evidence="6"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701759.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUJ6"/>
    <dbReference type="STRING" id="1459636.NTE_03307"/>
    <dbReference type="GeneID" id="41598959"/>
    <dbReference type="KEGG" id="nev:NTE_03307"/>
    <dbReference type="eggNOG" id="arCOG00989">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030083_0_0_2"/>
    <dbReference type="OrthoDB" id="6871at2157"/>
    <dbReference type="UniPathway" id="UPA00393"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016763">
        <property type="term" value="F:pentosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002099">
        <property type="term" value="P:tRNA wobble guanine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="entry name" value="Queuine tRNA-ribosyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10630">
        <property type="entry name" value="Uracil-DNA glycosylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01634">
        <property type="entry name" value="TgtA_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050076">
        <property type="entry name" value="ArchSynthase1/Queuine_TRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004804">
        <property type="entry name" value="TgtA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002616">
        <property type="entry name" value="tRNA_ribo_trans-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00432">
        <property type="entry name" value="arcsn_tRNA_tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00449">
        <property type="entry name" value="tgt_general"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46499">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46499:SF1">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01702">
        <property type="entry name" value="TGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88802">
        <property type="entry name" value="Pre-PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="tRNA-guanine transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-guanine(15) transglycosylase-like" evidence="7">
        <location>
            <begin position="11"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF85336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="509" mass="57242" checksum="FA6B4415287A425A" modified="2014-10-29" version="1">MAFEVRYTDLAARIGRLSTPHGEVETPAFVPVVHPVRQTISPQFLKEKMGFSLVITNAYITLKHYGDEARKRGIHNIIGFDGSVMTDSGGYQVLEYGSVEVEPAAMAQFEKDIKSDIPIPLDKPTGYGLPYGQAKEYVRITLENCKETLEVVGNDTDAVWVGPVQGAEHFDLVEHSAQALDGMGFQFMALGSPVELMEAYEFATLARMIARAKKVIPAKPVHLFGAGHPLTIPLAIALGCDTFDSASYMLYAKDGRYMHANGTARMEEMTYLPCQCPVCSSHTLKELRDMPRDQRMIEVAKHNLHVLKAEVDMTKQAIMDGRLWEYVMQKARAHPKLMEAVQLFGNNGEFDFIADGTPLFKEKAIFFFDPIDQYRPEARRFRQAVSRFATTKKKLVVFPEGEIHPFYATRGFKALAKKFPDAQIATYNPYLGIIPAEISDVFPASHNLTPRAERRTSDYQTFVESLQAFAGKFDEVIIVADEFMKQAAHEARLKARVEDYHSDHVIDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUU5</accession>
    <name>A0A075MUU5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUU5"/>
    <dbReference type="STRING" id="1459636.NTE_02900"/>
    <dbReference type="KEGG" id="nev:NTE_02900"/>
    <dbReference type="HOGENOM" id="CLU_1598937_0_0_2"/>
    <dbReference type="OrthoDB" id="374112at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="166" mass="18679" checksum="1806125D0C20D117" modified="2014-10-29" version="1">MLFSSARPLNDVSQVKSEIKKIIARQKRGSKDDLSAFQGEIDELVSALAEFYPEWKKLPAVFRVTRVKNNANIAAVYKENLLLPDVKHDLELVLKMLNHMRKGKGLPEVKVPLFVQPDEITLAQKEGKSDVAPGEIISQMAVVFQKGAVMWIGFVFGRDYVLLQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUZ5</accession>
    <name>A0A075MUZ5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitrogen regulatory protein PII</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02947</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701463.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUZ5"/>
    <dbReference type="STRING" id="1459636.NTE_02947"/>
    <dbReference type="GeneID" id="41598624"/>
    <dbReference type="KEGG" id="nev:NTE_02947"/>
    <dbReference type="eggNOG" id="arCOG02305">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082268_3_1_2"/>
    <dbReference type="OrthoDB" id="10960at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006808">
        <property type="term" value="P:regulation of nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002187">
        <property type="entry name" value="N-reg_PII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30115">
        <property type="entry name" value="NITROGEN REGULATORY PROTEIN P-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30115:SF11">
        <property type="entry name" value="NITROGEN REGULATORY PROTEIN P-II HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00543">
        <property type="entry name" value="P-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00340">
        <property type="entry name" value="PIIGLNB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00938">
        <property type="entry name" value="P-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="GlnB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51343">
        <property type="entry name" value="PII_GLNB_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="O-UMP-tyrosine" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR602187-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="121" mass="13403" checksum="302DD82B2B64D75A" modified="2014-10-29" version="1">MKELDIIIPHEQLNEVNSVLHKHKVGGMYFTQITGRGRAKREEVEVLVGPDQYKTGKRYVPEFGGRTMITIVVPDQMEKPIVDDIISKISTGEASDGKIFVKSITEAYDIGTKTAGEKAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MV46</accession>
    <name>A0A075MV46_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03498</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701910.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MV46"/>
    <dbReference type="GeneID" id="41599122"/>
    <dbReference type="KEGG" id="nev:NTE_03498"/>
    <dbReference type="HOGENOM" id="CLU_1478850_0_0_2"/>
    <dbReference type="OrthoDB" id="13224at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="182" mass="20879" checksum="DB757708EA75C156" modified="2014-10-29" version="1">MVENDKADDCNNTNDDAIAAELDSILDSYADDETRPQDNVLNEEQEQEFLARFERIKVEVIKPTMEEIGKYLERKGHSYQIKDNASPYHDENPIIKMEIYPKISAADDGRLQEHEFPTIAFIAEPDIATVGIEVRDGMPRRPGLTRGHTTNLESLTKEYVRNQIITVIKMNFVKRPARKNSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MV66</accession>
    <name>A0A075MV66_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Inorganic pyrophosphatase</fullName>
            <ecNumber evidence="7">3.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Pyrophosphate phospho-hydrolase</fullName>
            <shortName evidence="7">PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ppa</name>
        <name evidence="8" type="ORF">NTE_03018</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>diphosphate + H2O = 2 phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="7"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701522.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MV66"/>
    <dbReference type="STRING" id="1459636.NTE_03018"/>
    <dbReference type="GeneID" id="41598688"/>
    <dbReference type="KEGG" id="nev:NTE_03018"/>
    <dbReference type="eggNOG" id="arCOG01711">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073198_1_0_2"/>
    <dbReference type="OrthoDB" id="134160at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00412">
        <property type="entry name" value="pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.80.10:FF:000003">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.80.10">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00209">
        <property type="entry name" value="Inorganic_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008162">
        <property type="entry name" value="Pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036649">
        <property type="entry name" value="Pyrophosphatase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002317">
        <property type="entry name" value="PRK01250.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10286">
        <property type="entry name" value="INORGANIC PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00719">
        <property type="entry name" value="Pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50324">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00387">
        <property type="entry name" value="PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF85053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="179" mass="20120" checksum="1794E69B1A31D15D" modified="2014-10-29" version="1">MALVDTLKAGKNPPEEINVVIEIPKGSNIKYEIDDETGALFVDRKLFTAMFYPCNYGFVPQTEEKDGDPVDVLVLGNDPVVPSSVIRANPVGVLITADEEGEDAKVVAVPVAKVDPSFSDVKDIQNVPQHIQDQIKHFFEHYKELEKGKYVKVKGWENKESAKKKITEAMERYKKKDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MV72</accession>
    <name>A0A075MV72_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ferredoxin subunit of nitrite reductase and ring-hydroxylating dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NTE_03028</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701532.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MV72"/>
    <dbReference type="STRING" id="1459636.NTE_03028"/>
    <dbReference type="GeneID" id="41598698"/>
    <dbReference type="KEGG" id="nev:NTE_03028"/>
    <dbReference type="eggNOG" id="arCOG02852">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055690_5_3_2"/>
    <dbReference type="OrthoDB" id="6837at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21496">
        <property type="entry name" value="FERREDOXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21496:SF0">
        <property type="entry name" value="RIESKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="6">
        <location>
            <begin position="12"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF85063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="144" mass="15770" checksum="7A6CECF598369FBF" modified="2014-10-29" version="1">MKEEASVQGKSVEVARMQEIPAGKIKHVEVDGKEIAVANIDGKYYAFDDRCGHSSARLSMGTINGNVVTCPFHGAQFDCTTGRKVRDANTVAPPTDGLPDVWKKNVEYAYNILSYIKTYDQKTYGVTVEGDRIKVSLLPAAVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVE8</accession>
    <name>A0A075MVE8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding ferritin-like protein (Oxidative damage protectant)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_01156</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Dps family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700026.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVE8"/>
    <dbReference type="STRING" id="1459636.NTE_01156"/>
    <dbReference type="GeneID" id="41596968"/>
    <dbReference type="KEGG" id="nev:NTE_01156"/>
    <dbReference type="eggNOG" id="arCOG01101">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098183_2_0_2"/>
    <dbReference type="OrthoDB" id="8265at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01043">
        <property type="entry name" value="DPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002177">
        <property type="entry name" value="DPS_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42932:SF3">
        <property type="entry name" value="DNA PROTECTION DURING STARVATION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42932">
        <property type="entry name" value="GENERAL STRESS PROTEIN 20U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005900">
        <property type="entry name" value="Dps"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01346">
        <property type="entry name" value="HELNAPAPROT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin/DPS" evidence="4">
        <location>
            <begin position="33"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF83229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="178" mass="20226" checksum="D6D0207C684B7454" modified="2014-10-29" version="1">MQSTKPKIESHPVPTQLATRTDLSPQEVKAITEAVNPLIADAFALYVKTKNFHWHLYGSHFRDYHELFDEHADSIFESIDIMAERVRKVGGTTIRSISHIGQLQTIKDDNSSMVPAGDMVQILMEDNGHIAKMIRDAITVCDKNRDSATSNQLQDILDKTERRKWFLYEVAQGAKNTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVJ6</accession>
    <name>A0A075MVJ6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01217</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700081.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVJ6"/>
    <dbReference type="STRING" id="1459636.NTE_01217"/>
    <dbReference type="GeneID" id="41597026"/>
    <dbReference type="KEGG" id="nev:NTE_01217"/>
    <dbReference type="HOGENOM" id="CLU_1954557_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="128" mass="14568" checksum="56B891C3D9347EA6" modified="2014-10-29" version="1">MTEDLHISETTTNVEETKSGISEADLKLPTIDAETQRVIIEKGANIVARLAGIDVKPVEDKRSVSIQLTKEEYENFNLWSEELARKKIIPRASMSSVIKFSAVQYLEIINDQVRKQVQKQQEVKKSDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVQ1</accession>
    <name>A0A075MVQ1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02669</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVQ1"/>
    <dbReference type="KEGG" id="nev:NTE_02669"/>
    <dbReference type="HOGENOM" id="CLU_2949093_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="59" mass="6711" checksum="E72AAC7950613527" modified="2014-10-29" version="1">MIAMGEWGVLPVEHGSFQLLLLYSQEKLSYGPMSSAVKLCFRMECHPLKPEPFVKRKAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVS1</accession>
    <name>A0A075MVS1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02679</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701242.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVS1"/>
    <dbReference type="GeneID" id="41598369"/>
    <dbReference type="KEGG" id="nev:NTE_02679"/>
    <dbReference type="HOGENOM" id="CLU_1405920_0_0_2"/>
    <dbReference type="OrthoDB" id="377130at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="193" mass="19939" checksum="5B3C5E60ECFA53EF" modified="2014-10-29" version="1">MSRLGRYEKVVILAMLATGLVTASMTMAVAPRAFAQAAVSAAAQLSSTESIQPTDTAPVVVTMNSNDYINAGVTHSNTSNTGDVVVNEPGAYLIVAAGQVGKTSGNNTTCNVDLWLRQNDKDVANSNTRASVISTNDTIVLVSQAILLLNKGDKINTMVSVSATDQGCGLINTAPAGEPDIPAIIFSIARIGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVV9</accession>
    <name>A0A075MVV9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03362</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVV9"/>
    <dbReference type="KEGG" id="nev:NTE_03362"/>
    <dbReference type="HOGENOM" id="CLU_923176_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="301" mass="33213" checksum="B94A0540AC2E2B95" modified="2014-10-29" version="1">MRGGNSQFANRLYMCWTGTGGGNTILFKRLIPLSSTVVTLATGSAPGFVQGCNIAVAQDGTIYVVYERTGTNGNGGIELRRNTAGGDSGGWDSTTYTVGNWTRFTLTCGDNFVQCIKGYNGNTIRVTHYPSIATDPETGVHVVWTTNNTNTGADVLYANADPCCSFSTPVKIDLETNKTDQWEPAIAISNAAVIHVSAYDRRFDANNTWYRQYDYYCYYSFTACDSQSLWFNKQITLVNSTNLDTTDGTTHARNFVDDYHGIATSSEASPGREAYIVWTDSRNINPSNLHNFDIYFDMTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVX7</accession>
    <name>A0A075MVX7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable cobalt-precorrin-6B C(15)-methyltransferase (decarboxylating)</fullName>
            <ecNumber evidence="5">2.1.1.196</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">cbiT</name>
        <name evidence="7" type="ORF">NTE_03264</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin-7.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Co-precorrin-6B + S-adenosyl-L-methionine = Co-precorrin-7 + S-adenosyl-L-homocysteine + CO2</text>
            <dbReference type="Rhea" id="RHEA:36067"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:70791"/>
            <dbReference type="ChEBI" id="CHEBI:72780"/>
            <dbReference type="EC" id="2.1.1.196"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; adenosylcobalamin biosynthesis; cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 8/10.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the methyltransferase superfamily. Archaeal-type CbiT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.196" evidence="5"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701724.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVX7"/>
    <dbReference type="STRING" id="1459636.NTE_03264"/>
    <dbReference type="GeneID" id="41598919"/>
    <dbReference type="KEGG" id="nev:NTE_03264"/>
    <dbReference type="eggNOG" id="arCOG00977">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094143_0_0_2"/>
    <dbReference type="OrthoDB" id="6027at2157"/>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00229"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043776">
        <property type="term" value="F:cobalt-precorrin-6B C5-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019251">
        <property type="term" value="P:anaerobic cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00786">
        <property type="entry name" value="CbiT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023475">
        <property type="entry name" value="CbiT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014008">
        <property type="entry name" value="Cbl_synth_MTase_CbiT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050714">
        <property type="entry name" value="Cobalamin_biosynth_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02469">
        <property type="entry name" value="CbiT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43182">
        <property type="entry name" value="COBALT-PRECORRIN-6B C(15)-METHYLTRANSFERASE (DECARBOXYLATING)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43182:SF1">
        <property type="entry name" value="COBALT-PRECORRIN-7 C(5)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="2 5 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="6">
        <location>
            <begin position="38"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="47"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF85293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="193" mass="20886" checksum="95F1A117B430D8BC" modified="2014-10-29" version="1">MWAYRTPGIPDELFERTEDVPITKEDVRALAISKLRLKEGYSAIDVGCGSGSITVELCLQTKGGQVYAIDFDSNAIELTKKNLAKFGTEAQVILGKAQDVLPALPQVDAVIVGGTWGDTRQVIQLAMDRLKKGGRIVIDTILIETMYQALAAVGEMGLKDVDVTQVTIAKARKVTTGTMMLARNPVMMISATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MW37</accession>
    <name>A0A075MW37_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03334</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MW37"/>
    <dbReference type="STRING" id="1459636.NTE_03334"/>
    <dbReference type="KEGG" id="nev:NTE_03334"/>
    <dbReference type="eggNOG" id="arCOG10586">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_165871_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="87" mass="9555" checksum="5327CF9BB27E5E7C" modified="2014-10-29" version="1">MLPMSDDKQDIEKMIGRRVENMKGIYILGFALCWAATAGGVYVGVTVYPWAYPLPSGLYALSLLTVIEALGFFFIMKITGEKTITAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MW74</accession>
    <name>A0A075MW74_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-type Fe3+-hydroxamate transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02854</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701389.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MW74"/>
    <dbReference type="STRING" id="1459636.NTE_02854"/>
    <dbReference type="GeneID" id="41598536"/>
    <dbReference type="KEGG" id="nev:NTE_02854"/>
    <dbReference type="eggNOG" id="arCOG04233">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038034_9_1_2"/>
    <dbReference type="OrthoDB" id="9784at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd01144">
        <property type="entry name" value="BtuF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1980">
        <property type="entry name" value="Nitrogenase molybdenum iron protein domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051030">
        <property type="entry name" value="Vitamin_B12-ABC_binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42860">
        <property type="entry name" value="VITAMIN B12-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42860:SF1">
        <property type="entry name" value="VITAMIN B12-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53807">
        <property type="entry name" value="Helical backbone' metal receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="1">
        <location>
            <begin position="2"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="304" mass="33506" checksum="108AB2289C09311F" modified="2014-10-29" version="1">MRIVSFLPSATETLYELGLGHHIVGVTHECKHPPAARKKPQVIRPSFDPASMSGKEIDSKIVELVRSGGDIYIVDEKALKEADPELIVAQGLCEVCSPFTKEIGRAVSILGGRPDVLVLDPHDLDDVRVSIMDVAEKVGRVKEGRRLVSSLQRRIDAVRALKIKNRPKVACIEWVDPPFTAGHWVPQMVEYAGGTNGLSAAGEQSRRTDLEEISKFDPDIIVMMPCGFGVKRTLEEMKVLKGNAKWESLRAVKQKNVYAVESGAYFSKPSPRTVVGLEILAKIIHPEAARKIKVPKGSYKKVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWN4</accession>
    <name>A0A075MWN4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved protein implicated in secretion</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701526.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWN4"/>
    <dbReference type="STRING" id="1459636.NTE_03022"/>
    <dbReference type="GeneID" id="41598692"/>
    <dbReference type="KEGG" id="nev:NTE_03022"/>
    <dbReference type="eggNOG" id="arCOG00452">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095961_1_0_2"/>
    <dbReference type="OrthoDB" id="11250at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="215" mass="23189" checksum="9C602E8E1036C629" modified="2014-10-29" version="1">MTMSKWVKSESVVTSTDDSSSVAAAASPKPGGPLRPRLEAVQKRIENQIAQLDELQSSLKVRDDETFRKLMASIKESNAQYSTVLSAELAKARQVSRVVSIAKVALEKIHGRLSSVSDFGDLVIVLSPAMAVVKNVRSSLVPFVPEMEEELGIISELLSGILVDAGQVGGYTINFETANEEAVRLVDEASSTVEHKMKEELPGIPDLPMVPTKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWP7</accession>
    <name>A0A075MWP7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Poly(3-hydroxyalkanoate) polymerase subunit PhaE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_01627</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Biopolymer metabolism; poly-(R)-3-hydroxybutanoate biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700414.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWP7"/>
    <dbReference type="STRING" id="1459636.NTE_01627"/>
    <dbReference type="GeneID" id="41597404"/>
    <dbReference type="KEGG" id="nev:NTE_01627"/>
    <dbReference type="eggNOG" id="arCOG06343">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1472030_0_0_2"/>
    <dbReference type="OrthoDB" id="8049at2157"/>
    <dbReference type="UniPathway" id="UPA00917"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042619">
        <property type="term" value="P:poly-hydroxybutyrate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010123">
        <property type="entry name" value="PHA_synth_III_E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09712">
        <property type="entry name" value="PHA_synth_III_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0583">PHB biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF83689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="183" mass="21147" checksum="5278C938870C42C7" modified="2014-10-29" version="1">MTDDSKNNNFTPGMTPEQASKMFDMWSEVLKLPTIGPMYAFTKDFNTYANEFVSLGKIMADMKTHTDQYWSMINAAYVKASKETAEKAPKQFVTKDDYDSYRKTMIEAFEDAFTGLYASSEFSQVYGKLFSSQLDMSRAMQTITERNFKVLNLPTRGEIDEILKDIHELKRSVRDLKRSVEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWX1</accession>
    <name>A0A075MWX1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lactoylglutathione lyase-like lyase</fullName>
            <ecNumber evidence="2">4.4.1.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.4.1.5" evidence="2"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987237.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWX1"/>
    <dbReference type="STRING" id="1459636.NTE_01713"/>
    <dbReference type="GeneID" id="41597482"/>
    <dbReference type="KEGG" id="nev:NTE_01713"/>
    <dbReference type="eggNOG" id="arCOG02708">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046006_10_7_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004462">
        <property type="term" value="F:lactoylglutathione lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052164">
        <property type="entry name" value="Anthracycline_SecMetBiosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33993">
        <property type="entry name" value="GLYOXALASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33993:SF2">
        <property type="entry name" value="VOC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="5"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="133" mass="14673" checksum="ADF315C2C61732C3" modified="2014-10-29" version="1">MAFKKVGAVILLVSSMDKSVKFYRDTLGLQLKSKSKDWTEFFKDGTVLALTPAKRKSMVSSGTGMLVGFMVGDMDATVKELKAKKVKFFKKPKDEPFGKHAVIEDPDGHLISIAEIKTKSDEGFDMLGMFGTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MXC9</accession>
    <name>A0A075MXC9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA mismatch repair enzyme (Predicted ATPase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700628.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MXC9"/>
    <dbReference type="STRING" id="1459636.NTE_01900"/>
    <dbReference type="GeneID" id="41597650"/>
    <dbReference type="KEGG" id="nev:NTE_01900"/>
    <dbReference type="eggNOG" id="arCOG01166">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_500258_0_0_2"/>
    <dbReference type="OrthoDB" id="10903at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="548" mass="61544" checksum="6092D7C8CEDE760E" modified="2014-10-29" version="1">MATQLKVHPSFFKEFATKTWVSPTEIVKELVENAFDEDATKVLVTVLKNGISIEDDSGMDQNGMEKFLLLGSPHKKVESISPKLKRLRTGRYGTGRLSFLTSFESMRIRTRRGSFHKAFMIDGNVLDRLFTGNAALDELKEPALKRDGTELVMSGSKVESDIFKLAKEIRKLAILRQPLFEVFIKSADSFSEWDFSGAQKITAPDIQGHKIPVSLDGGKIAGEIVIARRPLSDEERGIAVMVGNHIVTRSNFGFDTKLSRVTGYVRCDTLTSRFADKSALIEDEEYIRFNQSMKTFVIDTVIPSLTEYEDVLITREESKIYREIDKVLGQAMVDTLETQEEVQGYEMVDVKEVVRTSTSKSGEEEDKHPAARHGGAQMQEYEEIKPLAPESSGMGKAEHAKQETVAEPQSYRSVPVEEASDVQGEVVDVVDEKQVDGTVIRTKKIRKPIVKKTFALKRIGFKVIPYEDESDSRYSFTSDNVVFVNKANSTYKAESSRGDEFLLRHIINMVAESIASAKHPEGKEALELQNRLVSEAIRIHDYSVLKHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MXF8</accession>
    <name>A0A075MXF8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MXF8"/>
    <dbReference type="KEGG" id="nev:NTE_01930"/>
    <dbReference type="HOGENOM" id="CLU_123710_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="196" mass="19848" checksum="A77DB0440DAF9C8B" modified="2014-10-29" version="1">MSKLRHALSIGLAAATLAVVLTYVLGAPALLQTAQAEEGHNLFMSIIKGITGGHSSMAQMHGGGGAPASDSQQMQQGMSESQMQEMKQQGTMGLIANNILGSPKTLPAGGLAVNVVTGAIAFSIAAFVISWKQRSFAVAGLLAASGVILMILPLANINFVIPGPIIGVIVGLAILALGVAKGIGTARPTAVSARKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MXM1</accession>
    <name>A0A075MXM1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pirin-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_03328</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the pirin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987056.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MXM1"/>
    <dbReference type="STRING" id="1459636.NTE_03328"/>
    <dbReference type="GeneID" id="41598978"/>
    <dbReference type="KEGG" id="nev:NTE_03328"/>
    <dbReference type="eggNOG" id="arCOG02935">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064194_2_2_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd20311">
        <property type="entry name" value="cupin_Yhhw_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02910">
        <property type="entry name" value="cupin_Yhhw_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041602">
        <property type="entry name" value="Quercetinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43212">
        <property type="entry name" value="QUERCETIN 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43212:SF3">
        <property type="entry name" value="QUERCETIN 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02678">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17954">
        <property type="entry name" value="Pirin_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006232">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pirin N-terminal" evidence="3">
        <location>
            <begin position="13"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Quercetin 2,3-dioxygenase C-terminal cupin" evidence="4">
        <location>
            <begin position="160"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF85357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="246" mass="27987" checksum="82692F2E86C488F1" modified="2014-10-29" version="1">MTTKIVRASEHFHHEEGDWLSTYWHFSFDFYRDPQNMGFGPLRVFNDDVIKPGKGFGFHPHRDMEIITYVIDGELEHRDDKGNHGVIYAGEIQRMTAGTGIVHSEYNHSKEKPLRLLQMWVQANKRGLAPSWEQQKFSTDERKDRLLPVVVAEGTNNASSKRAVHMHQDASMYVSSLGAGKQVEHALAQDRKAYVFVIDGDATVNGQKMQKQDAARIEDENKVSIRAGKPAEIILVDLPGRYDVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MXW6</accession>
    <name>A0A075MXW6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD-dependent aldehyde dehydrogenase</fullName>
            <ecNumber evidence="5">1.2.1.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_03439</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.16" evidence="5"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987057.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MXW6"/>
    <dbReference type="STRING" id="1459636.NTE_03439"/>
    <dbReference type="GeneID" id="41599077"/>
    <dbReference type="KEGG" id="nev:NTE_03439"/>
    <dbReference type="eggNOG" id="arCOG01252">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_1_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004030">
        <property type="term" value="F:aldehyde dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07100">
        <property type="entry name" value="ALDH_SSADH1_GabD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000009">
        <property type="entry name" value="Aldehyde dehydrogenase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000012">
        <property type="entry name" value="NAD-dependent succinate-semialdehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044148">
        <property type="entry name" value="ALDH_GabD1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047110">
        <property type="entry name" value="GABD/Sad-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43217">
        <property type="entry name" value="SUCCINATE SEMIALDEHYDE DEHYDROGENASE [NAD(P)+] SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43217:SF1">
        <property type="entry name" value="SUCCINATE SEMIALDEHYDE DEHYDROGENASE [NAD(P)+] SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="4">
        <location>
            <begin position="4"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF85467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="472" mass="51527" checksum="6E84C0ED8D240164" modified="2014-10-29" version="1">MMNNKIKTVNPATGHVINEYDMMTEEQILAAVKKAKEAFGEWKNNEKGGQNKRADFLHNFASQLRKNKEKLARVATSEMGKAIKESRSEVEKCAMTMDYYADNGSIFVGDELINTNARKSFITFEPLGVIGSIMPWNFPYWQALRFAAPSLMVGNTVVLKPASATMQCGIEIENTFREAGLPDGVFQTLVGDSSIANTLIDSNVSAVTFTGSVSAGAKVAQRTTSQIKKCVLELGGSDPFIVCEDADIEKASSGAVKGRFINCGQSCIASKRFIVTKKAANEFIEQFIQKTEKLVVGDPLIDSTDMGPLVNESAVNNIESLVQDAVKNGAKVLTGGERLTHGSDKGYFYKPTILENISPKMRVAREEVFGPVAPITIAEDEMEAIKIANDSEYGLGASVWTADLDKADKLSRTIEAGVVTVNNTVASDPRIPFGGVKKSGFGRELSRYGMLEFVNIKSVRFYDQLDSHHHVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MZG1</accession>
    <name>A0A075MZG1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MEMO1 family protein NTE_02596</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_02596</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the MEMO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226986984.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MZG1"/>
    <dbReference type="STRING" id="1459636.NTE_02596"/>
    <dbReference type="GeneID" id="41598289"/>
    <dbReference type="KEGG" id="nev:NTE_02596"/>
    <dbReference type="eggNOG" id="arCOG01728">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038085_2_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07361">
        <property type="entry name" value="MEMO_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.830.10">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00055">
        <property type="entry name" value="MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002737">
        <property type="entry name" value="MEMO1_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04336">
        <property type="entry name" value="AmmeMemoSam_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001987">
        <property type="entry name" value="PRK00782.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060">
        <property type="entry name" value="PROTEIN MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060:SF0">
        <property type="entry name" value="PROTEIN MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01875">
        <property type="entry name" value="Memo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53213">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF84639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="285" mass="30812" checksum="34329A36F3D10032" modified="2014-10-29" version="1">MTKPTNRPPAVAGMFYPSSEHELRLTIDQSFRNTKFGPGMPPPALTEERRIYGIVSPHAGYAYSGAVAANGFYAISASDFDNVVMVGPNHYGIGSGVATMRSGTWETPLGQVQVNSEWAQEIAKKSGIVDFDDFAHSRDHCLEVQLPFLQSIKSKFTIVPVILIMQDIDTAFDVGKAIADTVAENPKTKTMLVASSDLTHYEPNIMAHEKDNELIKAMLTLDVTKFYAVLERMDVSACGYGAIASIMVAAKNLGATRGELLKYATSGDVTGDTDAVVGYSSVIFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MZH6</accession>
    <name>A0A075MZH6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hydrolase or acyltransferase of alpha/beta superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02611</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MZH6"/>
    <dbReference type="STRING" id="1459636.NTE_02611"/>
    <dbReference type="KEGG" id="nev:NTE_02611"/>
    <dbReference type="HOGENOM" id="CLU_046066_2_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052897">
        <property type="entry name" value="Sec-Metab_Biosynth_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017:SF11">
        <property type="entry name" value="ESTERASE_LIPASE_THIOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="47"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="269" mass="28912" checksum="2BA2CDFD9BEFB006" modified="2014-10-29" version="1">MTLSIILMGIKPTIQSSFASKEGAITLVQADQSKSMATTNNNKTMSIVLVHGLWADASSWSKVIPILKKAGYNVIAPQLPLHSLKDDVATVNRAVELAGGPVILAGHSYAGFVITNAAYNNPNVKGLVYVSAFAPDNGKSITDYVDVTKLPKDLLVLDSSGFAYINPAFFHDTFAQDLDKAQTDVMAVVQKPVNQSIFGEKSGPPAWKQLPTWFQVSENDHLIPLDLQRTFAQQMNATTISLPSGHASLVSHPNEVAQLILNATKGASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MZI3</accession>
    <name>A0A075MZI3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MZI3"/>
    <dbReference type="KEGG" id="nev:NTE_02616"/>
    <dbReference type="HOGENOM" id="CLU_2257228_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="103" mass="10185" checksum="71E11B31CC91A2CC" modified="2014-10-29" version="1">MSSNQTTKIVLTGVVLLALAAMITAAVVSPDLAFARSSHSHGGNGGHGGDGGDGGDAFCPGRDNECDGGDGGGDAFCPGRDNGCDGGDFCPGHDRDCTDERGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MZX5</accession>
    <name>A0A075MZX5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PEFG-CTERM sorting domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701307.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MZX5"/>
    <dbReference type="STRING" id="1459636.NTE_02752"/>
    <dbReference type="GeneID" id="41598441"/>
    <dbReference type="KEGG" id="nev:NTE_02752"/>
    <dbReference type="eggNOG" id="arCOG08033">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG08038">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088139_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027560">
        <property type="entry name" value="PEFG-CTERM"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04296">
        <property type="entry name" value="PEFG-CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="272" mass="28660" checksum="FF9583D090CE11AE" modified="2014-10-29" version="1">MEYKAYALMAILLASVSAVGMFGSAYAQTSSGLTVTTDKTDYSAADTVKISGNVGVTPTGQPLVLQVFNPNGAAYRFDQVPVAADGSYTYNLKVGGKLGVTGAYKVTVSYNGVSKTANFNFAAGEQWQTIKMQLKSGTVDIKYQITGGTLKSLTGDSDTSTITAMITAASDGQLKIQLPRTVADAKMAGNTTDAEYVIFVDEIEDFADDDHGKDVRTLTIPFAAQSEQIDITGTFVAIPEFGAIAAIVLAVAIVGIIVATTKYSKFSFLPKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N052</accession>
    <name>A0A075N052_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02841</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385555.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N052"/>
    <dbReference type="STRING" id="1459636.NTE_02841"/>
    <dbReference type="GeneID" id="43502661"/>
    <dbReference type="KEGG" id="nev:NTE_02841"/>
    <dbReference type="eggNOG" id="arCOG08812">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_431255_0_0_2"/>
    <dbReference type="OrthoDB" id="11778at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049886">
        <property type="entry name" value="CFI_box_CTERM_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041770">
        <property type="entry name" value="CFI_box_CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="541"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="573"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="600"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="634" mass="67101" checksum="A9AC7BD52311EF1F" modified="2014-10-29" version="1">MSVKRYLAPLLLATLVFFSGSTLSAYGHGVGTDKSLPVAIGGRQVAVEASLSPNDIDTAGKAQPTLMIRTLDAGNNATIAGIDYHVTVAKDDKILLDQEFHSSDGIVFAKLTPDASAKVAQVNGQANPDRVNVSKDAPVEIKSMMMSDGGLYKIAVTLQGSSTGLQVGSDQTFDLYVSVSSTQDFTVQTAEGNQKMSVKTYYADASSLDYDRATNSISFSMPFNWSSTYVSQVPVVHMELEFPKALKELQVNGYHGYANGKELPIDAVLIDDYSSEDLRLVHFVLNNDRLTSIPASGGSSGNGTIDFVLKTSEKPKFPLDLLSTTQKYLWEMSWGPEVIESGVPTTFVMNLQNNQATGGMSTLLENAAFDFVITKDGQEVYRQHLTSGMGTFTTQYAFPAAGSYSVTAQKINGENESAKIDVVVLQGDNTNNPAPSQSQQQQQKPSGCLIATAAFGSELTPQVQFLRGFRDDYVLKSMSGSAFMDVFNTVYYSFSPQVADYEREQPWLQATVKAAVYPLFGILMASEQAFSSAGGGEGGTILAGAVASTLIGAVYVSPLAAGAAIAARKKVNLRIVAIAALAAAGALTATLAALAAGSALALSITTPAFVVALAAAAALAVVRLVQKKISRDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N134</accession>
    <name>A0A075N134_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03157</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385615.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N134"/>
    <dbReference type="STRING" id="1459636.NTE_03157"/>
    <dbReference type="GeneID" id="43502671"/>
    <dbReference type="KEGG" id="nev:NTE_03157"/>
    <dbReference type="HOGENOM" id="CLU_3038865_0_0_2"/>
    <dbReference type="OrthoDB" id="374834at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="54" mass="6136" checksum="F99D868659DA3865" modified="2014-10-29" version="1">MQVLLSTKCRYCDILLEGREQFLGHMIHGHEMSVGQAETMWKSVYSYVNDGGAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N1E3</accession>
    <name>A0A075N1E3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701720.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N1E3"/>
    <dbReference type="STRING" id="1459636.NTE_03260"/>
    <dbReference type="GeneID" id="41598915"/>
    <dbReference type="KEGG" id="nev:NTE_03260"/>
    <dbReference type="eggNOG" id="arCOG10517">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_736932_0_0_2"/>
    <dbReference type="OrthoDB" id="11953at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="318"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="360" mass="38403" checksum="3891FF5DCF8755EF" modified="2014-10-29" version="1">MNYFQRGTLISEPAQRLSTGYIILTLGVLMAISGGTWDVTNHLLNKPETFFSPPHAVLYSGAGTAVFGAVLVLSASRAVKKTEWPARLAIAGVTLLLVAGPVDFWWHSLFGLDGLLSPPHAVLVSGMVTSGIGAMIGIIYAWPRIDNSSSNRRTLPKALLVLGMLPVWLAAAGSIDMFSLPFSDTGFFHFNPQPWAGAILAMLGFPLITAAIMVATFSLAGRKFGVASALAGTFVFVSAMTSIVPNEALWPTIPFYVSVMVPLVAVDATLSHWRSKSAIFAAGAIAGLAFFVLYYPLITHTFNEVVMPDRAVWASLTGIIYFEMVQTVFPLVAVPSAAMGILGAIIGQRMATRAELALLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N1K8</accession>
    <name>A0A075N1K8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ferredoxin subunit of nitrite reductase and ring-hydroxylating dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NTE_03320</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701769.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N1K8"/>
    <dbReference type="STRING" id="1459636.NTE_03320"/>
    <dbReference type="GeneID" id="41598971"/>
    <dbReference type="KEGG" id="nev:NTE_03320"/>
    <dbReference type="eggNOG" id="arCOG02852">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055690_5_0_2"/>
    <dbReference type="OrthoDB" id="6837at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21496">
        <property type="entry name" value="FERREDOXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21496:SF0">
        <property type="entry name" value="RIESKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="6">
        <location>
            <begin position="4"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF85349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="101" mass="11450" checksum="11EBBCCBD0A7707D" modified="2014-10-29" version="1">MTLVKVANQGEVMENGGKEINVNGTRIALFYSNGKYYALEALCRHQDKPIAPGKVDGEVVECPWHSWHYNIRTGELLDYLEGVKMTTYKVDVRGNDIYIDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N1W3</accession>
    <name>A0A075N1W3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03416</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701854.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N1W3"/>
    <dbReference type="GeneID" id="41599059"/>
    <dbReference type="KEGG" id="nev:NTE_03416"/>
    <dbReference type="HOGENOM" id="CLU_2613424_0_0_2"/>
    <dbReference type="OrthoDB" id="7090at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="78" mass="8801" checksum="CFE1B372E3C5F0D2" modified="2014-10-29" version="1">MNQNIIAIAFIYGGKDIVKLLGVDHISHLVELADEEIKTIIAILRFSSDACPIESLSEQRIEYDVVKNLISKFEEVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N240</accession>
    <name>A0A075N240_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03486</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N240"/>
    <dbReference type="STRING" id="1459636.NTE_03486"/>
    <dbReference type="KEGG" id="nev:NTE_03486"/>
    <dbReference type="HOGENOM" id="CLU_3387396_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="32" mass="3615" checksum="F44F3B5AE789FD99" modified="2014-10-29" version="1">MKKMTIVLILPMSEITSPKSEFLVDAYATFLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ML87</accession>
    <name>A0A075ML87_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetyl-CoA acetyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_00104</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.9" evidence="4"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699232.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ML87"/>
    <dbReference type="STRING" id="1459636.NTE_00104"/>
    <dbReference type="GeneID" id="41596047"/>
    <dbReference type="KEGG" id="nev:NTE_00104"/>
    <dbReference type="eggNOG" id="arCOG01278">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035425_4_0_2"/>
    <dbReference type="OrthoDB" id="167534at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00829">
        <property type="entry name" value="SCP-x_thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055140">
        <property type="entry name" value="Thiolase_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004720">
        <property type="entry name" value="PRK06064.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42870">
        <property type="entry name" value="ACETYL-COA C-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42870:SF6">
        <property type="entry name" value="ACETYL-COA C-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22691">
        <property type="entry name" value="Thiolase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="2">
        <location>
            <begin position="6"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="3">
        <location>
            <begin position="244"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF82186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="388" mass="40676" checksum="818C44B1952B1E19" modified="2014-10-29" version="1">MTNKVCVLGAGSTKYGKLNESIIEIAMSAAKDAIESAGITPKEIQAGYISNVFGVADKQVHMAPVIMSNLGISHVPGLTIESACGSGSVMFREAYANVAAGFYDCVLALGVEKVTHTGTTQSTTLFSYCSDFFYEGGNGASFPGLFASMARAYMTTHKATEEDLAHVAVKNHENGVLNPKAHVRKKITVDDVLKSPVVASPLKLLDCCPFSDGASATILCSEDFAKKSGRPYVEIIGSGRGASPAAVQGREDITTIPSTVAAAKAAYKMAGVTPKDIDFAEVHDCFTIAEIIDIEDLGFFPKGKAAHAVRDGATRLNGEIPVNPSGGLKSKGHPIGATGVGQVVEVFDQFTGRAGERTVKDAEIALTHNFGATGASAAVHLFRKVDRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLT1</accession>
    <name>A0A075MLT1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLT1"/>
    <dbReference type="STRING" id="1459636.NTE_00374"/>
    <dbReference type="KEGG" id="nev:NTE_00374"/>
    <dbReference type="eggNOG" id="arCOG08805">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2406203_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="92" mass="10774" checksum="DB0D16116CBCD3C0" modified="2014-10-29" version="1">MYETGFNNNNSSGSGEQERASSINVTFRVNVRIMNKLRTESEKRQTSLNAYINQILRQHVEWDLFEPKIGMIPHSQSRCWPIFLPVWTAMRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLU0</accession>
    <name>A0A075MLU0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00021</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLU0"/>
    <dbReference type="STRING" id="1459636.NTE_00021"/>
    <dbReference type="KEGG" id="nev:NTE_00021"/>
    <dbReference type="HOGENOM" id="CLU_214692_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="44" mass="5168" checksum="C4DAA40200EBF91A" modified="2014-10-29" version="1">MPSVREEKREEDLCIRCGGEMVHIGFKIYRCQVCGHEEKPEDVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLU8</accession>
    <name>A0A075MLU8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MEDS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00394</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699441.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLU8"/>
    <dbReference type="GeneID" id="41596277"/>
    <dbReference type="KEGG" id="nev:NTE_00394"/>
    <dbReference type="eggNOG" id="arCOG03567">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094092_0_0_2"/>
    <dbReference type="OrthoDB" id="13893at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025847">
        <property type="entry name" value="MEDS_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14417">
        <property type="entry name" value="MEDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MEDS" evidence="1">
        <location>
            <begin position="16"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="264" mass="29568" checksum="5BB63A30808425AC" modified="2014-10-29" version="1">MLRETHSLCLLQQTEYAYLYDIIGRYLSNGYAVIYAAEPNTDKVLERMARAGIDVEQYFENGMLKVMSLDSVYISDHEKNLSVSQTLESWHNIISRTMDETKAKGILAIGSTDAFIQDGQEEHVKEYEDSIGKRPRSLTEAVCCYDTDSFSDTSVSTLIAILNAHEYTIHYGAQYAEWKEDKLQSVLASAFNKVLGSTTSDLMLKTLKSVYKIDEKTILSDPEVLESAVAKFFKDSSPAILAAVLKDLKTEIAFRRQVPAVSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MM82</accession>
    <name>A0A075MM82_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Restriction endonuclease S subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_00286</name>
        <name evidence="4" type="ORF">NTE_01142</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MM82"/>
    <dbReference type="STRING" id="1459636.NTE_00286"/>
    <dbReference type="KEGG" id="nev:NTE_00286"/>
    <dbReference type="KEGG" id="nev:NTE_01142"/>
    <dbReference type="eggNOG" id="arCOG02626">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037003_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.220.20">
        <property type="entry name" value="DNA methylase specificity domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044946">
        <property type="entry name" value="Restrct_endonuc_typeI_TRD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052021">
        <property type="entry name" value="Type-I_RS_S_subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30408:SF12">
        <property type="entry name" value="TYPE I RESTRICTION ENZYME MJAVIII SPECIFICITY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30408">
        <property type="entry name" value="TYPE-1 RESTRICTION ENZYME ECOKI SPECIFICITY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116734">
        <property type="entry name" value="DNA methylase specificity domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0680">Restriction system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF82368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF83215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="553" mass="62630" checksum="E6735C5C18334006" modified="2014-10-29" version="1">MIYHILAMNLWNGGIGKAGNKMALVSREEHQNAATLRSLSLKSSWIFSGDLRLDADYYAKEKDLALRILNDKRFSTRPLKTLVQRKMFSGYRFKRIYAGDKEKGIPYLSATETLMFRPKSERYLSKSKTENLDDLLVKEGWILMTCSGVIGRLTIVDKNLSQFVLTHDLIRIIPNEEEIPSGYLYAFLSTWIAQSVVTRDQYGLAINHVEPHQIEDLAVPILDKKIMGLFDHQIKYAYSLRQQANKKLDEAEALFYDSAGLTREIDNPLKNRKSFSLKSSSLDTRLDASFHNPVLIETLRMLRKSSTKLVKTKDLGKVIVAPRFKRIYVEKEYGIPFLQGSDLPMNRPFNLKYLSRKMTASLNNWIIKPGWTLVTCSGTIGRIGLTTPITDGWAASQHILRIIPHKDKPSELEYPVDAAYIATFLSTPYGYNQVVAKTYGGVVDEIGEKDIGQVLIAVIHDQSVHNAISQLTREAYAFKDLAALVEHETVSLLENLLEGSIKFSSVDNLRKALEETIELKAKVDSVNKIYEGINEVDEGYVVSFDDIKSKYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MM85</accession>
    <name>A0A075MM85_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyl transferase</fullName>
            <ecNumber evidence="5">2.4.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_00138</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="5"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MM85"/>
    <dbReference type="STRING" id="1459636.NTE_00138"/>
    <dbReference type="KEGG" id="nev:NTE_00138"/>
    <dbReference type="eggNOG" id="arCOG00894">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1014170_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050256">
        <property type="entry name" value="Glycosyltransferase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054145">
        <property type="entry name" value="MGS_GT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48090:SF10">
        <property type="entry name" value="GLUCOSYL-3-PHOSPHOGLYCERATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48090">
        <property type="entry name" value="UNDECAPRENYL-PHOSPHATE 4-DEOXY-4-FORMAMIDO-L-ARABINOSE TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21969">
        <property type="entry name" value="MGS_GT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Mannosylglycerate synthase GT" evidence="4">
        <location>
            <begin position="80"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF82220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="260" mass="28988" checksum="AC78648E07B188AB" modified="2014-10-29" version="1">MASIRSHVSQPKFSNNNKKVAIIFCTKNSARTIENAIANVKQSPYAPSIIVIDGFSNDNTIELAKKAGATIAIEQPERKFPGKGIAMKAGLQEAEKMGAHIALFLDADIKNLTSEWVDALVEPVVERGYDMTRGFYERHPKDAAVTKLIARPMISVFFPELSGFEQPLSGEVCANIRVWTDLLKRNPPDGWGIDVWFLIEVAVLGHKVKEIFLGKKEHASFDAYREDVGKLSKMSEQVLFTIMQEAVKYNRLDAYRGVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMC3</accession>
    <name>A0A075MMC3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GYD domain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00321</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699391.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMC3"/>
    <dbReference type="GeneID" id="41596223"/>
    <dbReference type="KEGG" id="nev:NTE_00321"/>
    <dbReference type="eggNOG" id="arCOG11305">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_178999_0_0_2"/>
    <dbReference type="OrthoDB" id="7321at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="106" mass="11698" checksum="1C0027B602562E6A" modified="2014-10-29" version="1">MLFGVFASHSPESCPLNNEQSKRIFLGIDEKIKGGLKKYNVERLVAFYMSVLEHQWIIILDAENAHDVEAMCIDVGISATSMVKIVPLNEFSTVINRIAAGGNSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMC8</accession>
    <name>A0A075MMC8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ribbon-helix-helix protein, copG family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00326</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699393.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMC8"/>
    <dbReference type="GeneID" id="41596225"/>
    <dbReference type="KEGG" id="nev:NTE_00326"/>
    <dbReference type="eggNOG" id="arCOG08805">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100103_1_0_2"/>
    <dbReference type="OrthoDB" id="9412at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="Ribbon-helix-helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="205" mass="22988" checksum="EDE548D2C7F3C50C" modified="2014-10-29" version="1">MANNSSITFRVDDNNIDKLRKLADEEGMSLNTLINRILESYLEWEFIAPKVGFAPMQKSVLKDLFDYVPEEKLKEIATRAADSFEDELLMMRGKVDLDAVLAITKNRVKRSGFTLREFSKNTENGGAGIKLVLQHDVGHHWGVFSKTYIERLINNVGYPVKIESTDKSLTIEIGEPDGKAGVAGYKLHHAAVKSSSMKKQQQEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMD5</accession>
    <name>A0A075MMD5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative xylanase/chitin deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_00213</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMD5"/>
    <dbReference type="STRING" id="1459636.NTE_00213"/>
    <dbReference type="KEGG" id="nev:NTE_00213"/>
    <dbReference type="eggNOG" id="arCOG02876">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_613395_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003410">
        <property type="entry name" value="HYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50825">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0858">Xylan degradation</keyword>
    <feature type="domain" description="NodB homology" evidence="4">
        <location>
            <begin position="73"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="3">
        <location>
            <begin position="332"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="356"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="368"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF82295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="549" mass="58781" checksum="674BFBC9C4DD7308" modified="2014-10-29" version="1">MSSLYSLKNLAVFASTALVISLMLPLASWKAVAAPASAAIAGVAIHDDDGGGGEEEEDGNNSSNKEAAASTCSCVIFRLDDVQDEWLEPVQAAIIDKFIEKNAPLDLAVIMNSIGNDPAIVTKVRQALATGLIETALHGWNHVSYANLTLSEQHDTLKAANEKMQDLFGRKSAIFVPPYNEYNENTLKAMNQLGLKIISPEFDSEIESIYNPDEPDSPDNKVYKAIAGGSDTIIKDQFGVYHLPQVIGFYTYDSDPPTKTPLSKIESQIDSAIASYGYAVVTLHPQDFTVKDAGNNPTEELSGNEIKDLDTLITWITDSGYSIQTFSRASHVPLPPIIDNVPPDITAPPDKAIVSSSKLTKVDDLGSPTVSDNADPSPSVKNDATTRHGKGAGSFFVFEQGTTKVTWTATDKAGNTSNATQYVTVASTNDTVAPIGTIDAPTNGTIIKGSLSSPPPSTNTTTTGTAGAYIQVRGTAFDYESGVKVVEVRTNDTEYEIANQVTPGSWSNWTATLLVTHSGDTEVEARVTDFFGNQKWETNVVKVSLDSKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMH8</accession>
    <name>A0A075MMH8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NTE_00258</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699344.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMH8"/>
    <dbReference type="STRING" id="1459636.NTE_00258"/>
    <dbReference type="GeneID" id="41596170"/>
    <dbReference type="KEGG" id="nev:NTE_00258"/>
    <dbReference type="eggNOG" id="arCOG01389">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023978_4_2_2"/>
    <dbReference type="OrthoDB" id="43988at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06423">
        <property type="entry name" value="CESA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43630">
        <property type="entry name" value="POLY-BETA-1,6-N-ACETYL-D-GLUCOSAMINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43630:SF1">
        <property type="entry name" value="POLY-BETA-1,6-N-ACETYL-D-GLUCOSAMINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="375"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="405"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="439"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="5">
        <location>
            <begin position="126"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="88"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF82340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="473" mass="53221" checksum="2233C7B2B55FDFE5" modified="2014-10-29" version="1">MFDDLLSTSLSSSLLLFALSPGVETFIYNFANGFVAWISTLTIWDFITLTWFAFIIDISRNVGKAIILASDHFLRKWKKEYHYYSSSSLSAPFSTTTTTTTTDSDSRSSSSGGGSAVVGRFEPNISIIVPAHNEGAAIKHTIQSLLENSYPNKEIIVVDDHSTDNTYQEALPFMQKGQIKLVQRKSGKGSKSSAINYGVVFATGDYIMIMDGDTLVERTAIQEVVNQLGVRGVSAVSGNVRIFAGDGGKRNLLTRLQSYEYLVAFEVGRRYNALMNMLIIIPGAFGVFPRSLGKEIGMYDTDTIGEDFDLTIKLLKTGGKVSFASNAIAWTYCPNNWKGWLRQRIRWAHGQLAVLMKHKDTTGVYNTYRRQLVVAFYDMIMMDIVLVFVRMAGFAWVIAAYGDRLAYVMLMMLLLYLGNELVAILTAALFSPRKEDLKYVYLVPIMVFFYRPFYSCVRLYAYLKRLLKKDATW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMJ9</accession>
    <name>A0A075MMJ9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Four helix bundle sensory module for signal transduction</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00611</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385033.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMJ9"/>
    <dbReference type="STRING" id="1459636.NTE_00611"/>
    <dbReference type="GeneID" id="41596474"/>
    <dbReference type="KEGG" id="nev:NTE_00611"/>
    <dbReference type="HOGENOM" id="CLU_491459_0_0_2"/>
    <dbReference type="OrthoDB" id="86083at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="526" mass="56291" checksum="96C4A1FA1539F888" modified="2014-10-29" version="1">MDFKNRLILFFILIAVIPIIALSAVSTVTIIKFKDQIANIYSGYVTNVELLSKNKGDLLGMRSDLIQFASSPDPAQKKAGITHMMLLKNGIASTAGNYKTIEDLPGDFLPAEGVDLSKISADETVLVGTIAQQWKDYGTKVEDLAILSTDPSFSPQAQAEALQLVAQTDKLVSSYNDLLAVDAQIGEASRAQSQQVMQLAFFYGGLASAISAACATAAAILISKRVVLGDLVRMTKLELVETTLRDLIGGGSDALLQMVKSQMSQEGEGQVPRTVTVADVPSAVVPSASEDDVIIGKKKAKAFIEDDDPSAAAGRPTWAFAEDTDNNNSNSLKPTASAASKTKAFAARDLPAPPRVIDSYKGKLVLLNASRRFGHAAKALEDLLASPNTIVLTRKGSNIYYRITAQDNKSRLYILQSSSAGAGGFEEGSSSRKNNSDHVIPSDNEEKIAHEIESMIRKNPGSTILIDSATELIYTLGFEKAFSLLRRVSEVVSSYEGAGAVVLVNAKAHEPRIMEAISNIANDFVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMK2</accession>
    <name>A0A075MMK2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00283</name>
        <name evidence="2" type="ORF">NTE_01145</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699364.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMK2"/>
    <dbReference type="STRING" id="1459636.NTE_00283"/>
    <dbReference type="GeneID" id="41596957"/>
    <dbReference type="KEGG" id="nev:NTE_00283"/>
    <dbReference type="KEGG" id="nev:NTE_01145"/>
    <dbReference type="eggNOG" id="arCOG03130">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1451358_0_0_2"/>
    <dbReference type="OrthoDB" id="211024at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="186" mass="21471" checksum="DE566A11A506AB97" modified="2014-10-29" version="1">MPEYYFDIETVPLESFRGEEKAGTVPSKAKIVTIQYQQLHSVTGKPVGDLQILKEWEIGEQEMVEQFKKIYLDKGVWNFIPVGNNLAFESQFMKSKLKQYCNLEGLRLGHRPMIDLKHVLVIANGGRFDGYSRFLGKSGLAKNMESWYFDGNYDNILNYVKKEAEDFVKGYCILKKELPRVITVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MML0</accession>
    <name>A0A075MML0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699620.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MML0"/>
    <dbReference type="STRING" id="1459636.NTE_00621"/>
    <dbReference type="GeneID" id="41596484"/>
    <dbReference type="KEGG" id="nev:NTE_00621"/>
    <dbReference type="eggNOG" id="arCOG08691">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2340276_0_0_2"/>
    <dbReference type="OrthoDB" id="376678at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="97" mass="10638" checksum="76DCA79AFFBFB3DC" modified="2014-10-29" version="1">MGLVLADRKELETLLKAAAKDPKVATTIAGRMVPGQGDAKEFAYGLLAGMVIGSFMASFEARNSRQPDRDETADILSIVMSRMPTLRKAIMKHLEMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMP3</accession>
    <name>A0A075MMP3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_00338</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699402.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMP3"/>
    <dbReference type="STRING" id="1459636.NTE_00338"/>
    <dbReference type="GeneID" id="41596234"/>
    <dbReference type="KEGG" id="nev:NTE_00338"/>
    <dbReference type="eggNOG" id="arCOG02358">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015921_0_0_2"/>
    <dbReference type="OrthoDB" id="342253at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43547:SF2">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43547">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="328"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF82420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="544" mass="60761" checksum="DFFB1A9410993823" modified="2014-10-29" version="1">MGDSSEDKVTMVQGFDNIVQAVEDALNRTEQRWDACLDAATPRISAKMIGKAHQEARKRKVAIRYIIDITKDNVEYCKQIMANSGAEIRHSPGIQGSFGVSDDVYISSIRPIESNGHHVYGIQSTLKPIVEHHRSIFDTMWKTAIPGRLRIRELQEGISIPLLEVIENTRESLDLAYSKIMSAKSEVLIVFSTPNALRRNLPGKGLELLKTAVSHNVKVMLLIPNDVQLENEIKQLRLAIPQIEIRSIDESLKTRITIIVIDRTESFIFETKDDNAVTLDDALGESTHYNSGATSLSFASIFDSLWRQAGLYEKLKEMESMKDEFINIAAHELRTPVLPIVLCAENLEDSLPENENVKVILRNAKRMTKLAGDILDVSKIESKTFRLQKQKSNIVQLIEEAIQDARLKIPEGQQVDIIFESLLPPALEEMVIDKNRIRQVLENLLANAINFTDNGSIRVSVEKDAENQGFIRTSVTDSGKGIDPLIVDKLFGKFVSSSQKAKGTGLGLFLCKAIVEQHAGKIWGKNNIDVKGATFAFTLPYEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMP5</accession>
    <name>A0A075MMP5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00461</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMP5"/>
    <dbReference type="KEGG" id="nev:NTE_00461"/>
    <dbReference type="HOGENOM" id="CLU_204970_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="67" mass="7688" checksum="91B18B6C11624F2E" modified="2014-10-29" version="1">MTAKREDAREISHCVLCGRPIAGNEFVETIDSMNYSFDTKTCIITFKKLHSVYGSEFMTDFVNQGFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMU0</accession>
    <name>A0A075MMU0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00512</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMU0"/>
    <dbReference type="STRING" id="1459636.NTE_00512"/>
    <dbReference type="KEGG" id="nev:NTE_00512"/>
    <dbReference type="HOGENOM" id="CLU_2340012_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="97" mass="10447" checksum="2C61079B1D837C9C" modified="2014-10-29" version="1">MLPRLRIQIVHREVLADSLVSPVNPARVQPEALEVNLASPVRAVKGLVAALEVMPAAEVQAELAAFLVVAVQAAKVAQAELEVRVELLDFTHLIARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMY7</accession>
    <name>A0A075MMY7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00748</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMY7"/>
    <dbReference type="STRING" id="1459636.NTE_00748"/>
    <dbReference type="KEGG" id="nev:NTE_00748"/>
    <dbReference type="HOGENOM" id="CLU_1160051_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="262" mass="29966" checksum="6C9EC4901E4C80EA" modified="2014-10-29" version="1">MRVFSSRLHFCFAVEQLIRESVIACIPSAWDENHITYKIIETLKGKLNPDFVINSRNNTNVLWHPYKAKGKVETDFGDIAILVNIIYDDGKTLTGIGFLEAKRRNVHSKKFIQIKRRQLGRILKNAHYSRLLLYDYKDITQFADTSIFDRIPGSLHHSPFVPVTRSAVVPVSIALPKRITNISLYDFSLPFSYQLCFRYPNGLDLELSETSIGVVKGAIKKEYDSMEIPIAPKYIVAFSVSNGNRYPSLEYLPINRDLYVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MN68</accession>
    <name>A0A075MN68_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00514</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MN68"/>
    <dbReference type="STRING" id="1459636.NTE_00514"/>
    <dbReference type="KEGG" id="nev:NTE_00514"/>
    <dbReference type="HOGENOM" id="CLU_3227627_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="43" mass="4293" checksum="A525738F25D691E4" modified="2014-10-29" version="1">MVVAVQAALADSLVSPVNPARVQPVVKVAQAALAVQAAKVAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MN88</accession>
    <name>A0A075MN88_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00539</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987124.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MN88"/>
    <dbReference type="GeneID" id="41596410"/>
    <dbReference type="KEGG" id="nev:NTE_00539"/>
    <dbReference type="eggNOG" id="arCOG08684">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128582_1_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="131" mass="14958" checksum="A93EA6A03019E861" modified="2014-10-29" version="1">MVDNLKKICNEILSLDKSIRFAGITNKMGKVVAHQFREGVTPMLTFEELEGSAIKSVLRMKTREDYEAKLGRAVYTFTLYDKVKRASIPLQHEDYALLIASFEKDASHESIILSKILPVLQNEGLIKRHHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNM7</accession>
    <name>A0A075MNM7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNM7"/>
    <dbReference type="STRING" id="1459636.NTE_00335"/>
    <dbReference type="KEGG" id="nev:NTE_00335"/>
    <dbReference type="HOGENOM" id="CLU_125301_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12840">
        <property type="entry name" value="HTH_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="176" mass="19787" checksum="F65C9A5D3BC41006" modified="2014-10-29" version="1">MRVVYVVDNLAVAKILVDPMRRAILELLRTKPMTQAKLASELGLATPSLNHHMKVLRSKKLVIMVKRETEKHGAIQKFFAPAAYLFVYDLDALPKNIARYFYPVSLERTRGIVSTILFKDSHAPVPSTQEAMNALSEKISQALVLAAKEYPKQDLNSGLEEAVYKIYADAIKRAMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNR5</accession>
    <name>A0A075MNR5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">NTE_00370</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNR5"/>
    <dbReference type="STRING" id="1459636.NTE_00370"/>
    <dbReference type="KEGG" id="nev:NTE_00370"/>
    <dbReference type="eggNOG" id="arCOG02358">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG03644">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031353_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00075">
        <property type="entry name" value="HATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12914">
        <property type="entry name" value="PDC1_DGC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033479">
        <property type="entry name" value="dCache_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050736">
        <property type="entry name" value="Sensor_HK_Regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43711:SF1">
        <property type="entry name" value="HISTIDINE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43711">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02743">
        <property type="entry name" value="dCache_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="321"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="15">
        <location>
            <begin position="390"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="532"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="353"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="545"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AIF82452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="641" mass="70120" checksum="1FBCE7ADE03728A1" modified="2014-10-29" version="1">MVVNAIGNSKWLAMSLTIVIVASAISISVLFYSQQIANENIRDKLFEKAKQDQSRVTRTIASRIGSDLDSIAARLQVLAVSQGLQGGDLTGQDADRLARSVFSQITAAHRAIDAFYILDKDNMVVKVANTKEDTDSRQFLGFDASSRDYVKETRSSLGPVFSNVFVGADGRPRITITYPIINRDSGQYLGLVGVGAQSEPFFKEYGNVDDFNSSTYLNVLDRNAVYVASPNSAIVGKSFFDKDVQDEFVRNDPIINNFYRKFLSGQFADATFDVGFGERLATGQPVIVNGKAAYFVTLGIPTSLIYSDIESVLAQQNTQSLYHMAGLVSAAAILIFFLIRLNGRLAREVSERTRALAEANEQLTDTNQRLREANEEIKSHDKMQSEFINIAAHELRTPIQPIVGMTEILKNRLVHDSGGKGKVEVTAKQLELIDRNAKRLQKLSAEILDTTRIESGTFRLDLEVLEMNERMRSVIADAKSLIPHGQSIKIHFKPLADESGRPIPLLVKADKLRIFEVVSNLLRNAIKFSARDDDNGGSSGSSHGSNGGSGGGGTVITITTDRKDGEMVVVSVKDQGAGISADIFPRLFTRFSADRERGGTGLGLFIAKNIVEAHGGRIWAENNNKDGKGATFAFTLPLVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNS7</accession>
    <name>A0A075MNS7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NodB homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00705</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNS7"/>
    <dbReference type="STRING" id="1459636.NTE_00705"/>
    <dbReference type="KEGG" id="nev:NTE_00705"/>
    <dbReference type="eggNOG" id="arCOG04934">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1227692_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="228" mass="26411" checksum="55D1A3713CE48FB2" modified="2014-10-29" version="1">MPCEFSLTHYEEILEKVKDRAGTATERKDIILAHDIDIFPNYALQMASLEHKYGIKATYYILLHSEWYNALSPENMAVWKQIGELGHELALHYDGNYDSELQTIHAAFCAMIKTESINISQHLVGITPDIHIPPTLQDRAALVKQYSYKYIADSGGWWRNGCICTHADERLLFVCHPVWWVKSENPFDKVKVDAYAVIDRARNFWVEMVNEHRKQQYQQKVPVATRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MP50</accession>
    <name>A0A075MP50_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00864</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699809.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MP50"/>
    <dbReference type="GeneID" id="41596707"/>
    <dbReference type="KEGG" id="nev:NTE_00864"/>
    <dbReference type="HOGENOM" id="CLU_204996_0_0_2"/>
    <dbReference type="OrthoDB" id="374823at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="66" mass="7090" checksum="46481DBD066A18A1" modified="2014-10-29" version="1">MLASTTKLEVLKISLISEQVARLQVISCDLCGSQKASFDVYVKGAVEGVPALKRCCDSCKSLLITQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MP71</accession>
    <name>A0A075MP71_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00511</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MP71"/>
    <dbReference type="KEGG" id="nev:NTE_00511"/>
    <dbReference type="HOGENOM" id="CLU_3322768_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="38" mass="4657" checksum="F9437A4E868A70A4" modified="2014-10-29" version="1">MSVTFEAHRIQLCEKKYNLFFIFLAEEMVKREKVRTGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MP81</accession>
    <name>A0A075MP81_9ARCH</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01282</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700136.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MP81"/>
    <dbReference type="STRING" id="1459636.NTE_01282"/>
    <dbReference type="GeneID" id="41597085"/>
    <dbReference type="KEGG" id="nev:NTE_01282"/>
    <dbReference type="HOGENOM" id="CLU_1648358_0_0_2"/>
    <dbReference type="OrthoDB" id="373599at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="162" mass="18233" checksum="5983F6AB16D91108" modified="2014-10-29" version="1">MARKLPVVAGIAAAAAAGLMIFIFLGPWSIYVWTAIRGVPDSPLMYMTVDGKRHPADDNYYCGRGCEFSIYARTLSLQPIEMPRGSEADFSLDNRAISLRYHLLKYDDQQLEDSNQPLHFEENGKLVVDWPSGDYVISVIAGWDSIDENQAHSLHRFRITVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPQ6</accession>
    <name>A0A075MPQ6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01483</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPQ6"/>
    <dbReference type="KEGG" id="nev:NTE_01483"/>
    <dbReference type="HOGENOM" id="CLU_215623_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="52" mass="5991" checksum="28E0A10BB39AB507" modified="2014-10-29" version="1">MQILMQMLQRRLYYDNAMISAMQNYYKINDVHALTSFFQAAGLVVNDDDDGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPU8</accession>
    <name>A0A075MPU8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01077</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385116.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPU8"/>
    <dbReference type="STRING" id="1459636.NTE_01077"/>
    <dbReference type="GeneID" id="43502592"/>
    <dbReference type="KEGG" id="nev:NTE_01077"/>
    <dbReference type="HOGENOM" id="CLU_2534502_0_0_2"/>
    <dbReference type="OrthoDB" id="10194at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="83" mass="9191" checksum="6D3F726C9E48F390" modified="2014-10-29" version="1">MPAGTRIKQGDLEKVLSALDIDEGVRIESSAAGKKKKMFVNRSTSGIFVVQVGEEEFYYLDSAAQVAKLAYKVFGKKYSAYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPZ0</accession>
    <name>A0A075MPZ0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methylmalonyl-CoA epimerase</fullName>
            <ecNumber evidence="4">5.1.99.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_01107</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methylmalonyl-CoA epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.99.1" evidence="4"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699992.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPZ0"/>
    <dbReference type="STRING" id="1459636.NTE_01107"/>
    <dbReference type="GeneID" id="41596922"/>
    <dbReference type="KEGG" id="nev:NTE_01107"/>
    <dbReference type="eggNOG" id="arCOG02706">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046006_5_2_2"/>
    <dbReference type="OrthoDB" id="6161at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004493">
        <property type="term" value="F:methylmalonyl-CoA epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046491">
        <property type="term" value="P:L-methylmalonyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07249">
        <property type="entry name" value="MMCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017515">
        <property type="entry name" value="MeMalonyl-CoA_epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051785">
        <property type="entry name" value="MMCE/EMCE_epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03081">
        <property type="entry name" value="metmalonyl_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43048">
        <property type="entry name" value="METHYLMALONYL-COA EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43048:SF3">
        <property type="entry name" value="METHYLMALONYL-COA EPIMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13669">
        <property type="entry name" value="Glyoxalase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="3">
        <location>
            <begin position="2"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF83180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="143" mass="16017" checksum="EF0E1F90F34DDBAB" modified="2014-10-29" version="1">MRVDHIAIAVNNVDEALKNYQKILNVDHLEIETVPNEKVKVAMLMLEDTRIELMEPTSPDSPISKFLKERGEGIHHIAITADDIVKDVDRAKSQGMRMLGDLRTGSYGRRITFIHPKSLNGVLTEFCEAPPAADGHHHNNNAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPZ7</accession>
    <name>A0A075MPZ7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPZ7"/>
    <dbReference type="STRING" id="1459636.NTE_01175"/>
    <dbReference type="KEGG" id="nev:NTE_01175"/>
    <dbReference type="HOGENOM" id="CLU_1943761_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2830">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109709">
        <property type="entry name" value="KorB DNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="129" mass="14765" checksum="315F2CE13B201B0C" modified="2014-10-29" version="1">MPAIVKANADDRQVLAWAIIENLQRKDLTDRETAHGLKELYAAHGYDVNTAIQNLHIINNAESDNSRTTRPQKDFLSISKQVGLSAKRQREYLQLVRDIPEEVLNHAEKQGLSMEKKQLLTRPKVIFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQ84</accession>
    <name>A0A075MQ84_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01279</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385157.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQ84"/>
    <dbReference type="STRING" id="1459636.NTE_01279"/>
    <dbReference type="GeneID" id="43502601"/>
    <dbReference type="KEGG" id="nev:NTE_01279"/>
    <dbReference type="HOGENOM" id="CLU_2985484_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="57" mass="6316" checksum="72727D9CF1B017F6" modified="2014-10-29" version="1">MTEFSDSSSHQQKMSHSVPCELCDALSTEAEKAKAAGEADRAQLILFILREHKKACH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQE1</accession>
    <name>A0A075MQE1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Phosphoglucosamine mutase</fullName>
            <ecNumber evidence="12">5.4.2.2</ecNumber>
            <ecNumber evidence="12">5.4.2.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NTE_01223</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SR1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.2" evidence="12"/>
    <dbReference type="EC" id="5.4.2.8" evidence="12"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700086.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQE1"/>
    <dbReference type="STRING" id="1459636.NTE_01223"/>
    <dbReference type="GeneID" id="41597031"/>
    <dbReference type="KEGG" id="nev:NTE_01223"/>
    <dbReference type="eggNOG" id="arCOG00767">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016950_7_1_2"/>
    <dbReference type="OrthoDB" id="10363at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004614">
        <property type="term" value="F:phosphoglucomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008966">
        <property type="term" value="F:phosphoglucosamine mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004615">
        <property type="term" value="F:phosphomannomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03087">
        <property type="entry name" value="PGM_like1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000001">
        <property type="entry name" value="Phosphoglucosamine mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024086">
        <property type="entry name" value="GlmM_arc-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03990">
        <property type="entry name" value="Arch_GlmM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43771">
        <property type="entry name" value="PHOSPHOMANNOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43771:SF1">
        <property type="entry name" value="PHOSPHOMANNOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="Phosphoglucomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="9">
        <location>
            <begin position="5"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="10">
        <location>
            <begin position="152"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="11">
        <location>
            <begin position="256"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase C-terminal" evidence="8">
        <location>
            <begin position="400"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIF83295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="454" mass="49432" checksum="EEEFAFEB23358592" modified="2014-10-29" version="1">MQRTRLFGTNGVRGVWGNDFTSDLVIDLSYAIATYYKKGPIVVGYDGRKSSPVVSRLVRATLNSAGLDVADAGLVPTPCLQHAAKRLGYNGGIMITASHNPPEYNGIKPAASDGVEISREDELTVEDIYHSKKFATMAGCGRQYVDDNVVPTYMEKVLSLVDADRIRAKNFTVAMDTGNGAQSVVAPIIAKKLGCKVIVINGDIDGDFPGRGSEPTPDNLSVLAETVRNGRADFGVAFDGDGDRSIFCDNNGSIYWGDKTGSLLAKNLLAQRHRGSEIVCPVNTSMVLSKVAEESGIKVVHTKVGSVEVSREMVKRKAPMGLEENGGFMYGPINEVRDGAMTTALVLDMLAATGESFSRLVEKLPRTFQVKTKFVCSSREVVERVVKACMEHGSPKRIETMDGAKIWLDDETWLMVRPSGTEPLIRMYAESTDRALLDSKVDEYSRIVRSKMAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQG5</accession>
    <name>A0A075MQG5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribonuclease Z</fullName>
            <shortName evidence="9">RNase Z</shortName>
            <ecNumber evidence="9">3.1.26.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">tRNA 3 endonuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">tRNase Z</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">rnz</name>
        <name evidence="11" type="ORF">NTE_01391</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.</text>
            <dbReference type="EC" id="3.1.26.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 2 Zn(2+) ions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 9">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the RNase Z family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.11" evidence="9"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987203.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQG5"/>
    <dbReference type="STRING" id="1459636.NTE_01391"/>
    <dbReference type="GeneID" id="41597187"/>
    <dbReference type="KEGG" id="nev:NTE_01391"/>
    <dbReference type="eggNOG" id="arCOG00501">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031317_2_1_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042781">
        <property type="term" value="F:3'-tRNA processing endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07717">
        <property type="entry name" value="RNaseZ_ZiPD-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000002">
        <property type="entry name" value="Ribonuclease Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01818">
        <property type="entry name" value="RNase_Z_BN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013471">
        <property type="entry name" value="RNase_Z/BN"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000801">
        <property type="entry name" value="PRK00055.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02651">
        <property type="entry name" value="RNase_Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46018">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46018:SF2">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23023">
        <property type="entry name" value="Anti-Pycsar_Apyc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 9 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="8 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="10">
        <location>
            <begin position="202"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIF83458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="308" mass="33912" checksum="0A813C57BD5369D3" modified="2014-10-29" version="1">MAANMQMVFLGTSSAAPTPERGLSSIAIMRDGELLLFDAGEGMQRNFIKAGLGMNRKMKVFVTHMHADHCVGLLGLLQTMSLQGREKRLDIYGQPRLKEFLLENMRIINFGLTFEVAIHTIEGEGVVVQESDYRITCCEARHSVPALSYRLDESDRPGAFNVELVKKMGIPEGELYSKLQHGQDIEYNGKTVRSADVLGPPRPGRKIGISGDTRPTDKLTKFFSGCDVLVFESTYTHDKLAKALETSHSTATEAATVARQAGAKKLFLTHFSARYDETSALVKEASAIHADVEAAEDLKQVDIPYLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQH0</accession>
    <name>A0A075MQH0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">3-isopropylmalate dehydratase large subunit</fullName>
            <ecNumber evidence="6">4.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Alpha-IPM isomerase</fullName>
            <shortName evidence="6">IPMI</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Isopropylmalate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">leuC</name>
        <name evidence="8" type="ORF">NTE_01255</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterodimer of LeuC and LeuD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="6"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700113.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQH0"/>
    <dbReference type="STRING" id="1459636.NTE_01255"/>
    <dbReference type="GeneID" id="41597061"/>
    <dbReference type="KEGG" id="nev:NTE_01255"/>
    <dbReference type="eggNOG" id="arCOG01698">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006714_3_4_2"/>
    <dbReference type="OrthoDB" id="255at2157"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01583">
        <property type="entry name" value="IPMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01027">
        <property type="entry name" value="LeuC_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011826">
        <property type="entry name" value="HAcnase/IPMdehydase_lsu_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006251">
        <property type="entry name" value="Homoacnase/IPMdehydase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050067">
        <property type="entry name" value="IPM_dehydratase_rel_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033941">
        <property type="entry name" value="IPMI_cat"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01343">
        <property type="entry name" value="hacA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02086">
        <property type="entry name" value="IPMI_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001614">
        <property type="entry name" value="PRK00402.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822:SF2">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="5 6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="7">
        <location>
            <begin position="6"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="7">
        <location>
            <begin position="291"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="363"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF83325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="424" mass="46030" checksum="E95F831E0581B6C5" modified="2014-10-29" version="1">MTITEKILARAAGRQSVSPGDVVFAKVDKVMMHDVSGPGVIKVFSEWEKKGLKLDKIWNADRVWVTEDHFVPAADRVSAENVITLSNFTKKYGIKKHFKYGLGQYGICHTLSHEEAMVLPGEVYVGGDSHTNTTGAMGAFAAGLGHTDVAYVLMNGEIWFKIPETMMFRVEGNKPDHIMAKDIILKIIGEIGTDGANYKTMQFAGNVVEKLSMEERLTLTNMTTEAGAKNGIIEPDETTYAYLRERTDAQYSPVHGDEGAQYSETFTIEIEKMEPTIAKPFSPGNISVARELQGTEIDKAYIGSCTGAKLDDLRAAAKILKGKKVKIRTEVLPAAQSIYVKAMKEGLVQIFMEAGAVVGPPTCGACCGAHMGVLGKGEICISTTNRNFPGRMGHVESQTYLASPVVVAASAITGKITDPRDVRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQM0</accession>
    <name>A0A075MQM0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Site-specific recombinase XerD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NTE_01770</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700533.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQM0"/>
    <dbReference type="STRING" id="1459636.NTE_01770"/>
    <dbReference type="GeneID" id="41597540"/>
    <dbReference type="KEGG" id="nev:NTE_01770"/>
    <dbReference type="eggNOG" id="arCOG01245">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_682577_0_0_2"/>
    <dbReference type="OrthoDB" id="142231at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050090">
        <property type="entry name" value="Tyrosine_recombinase_XerCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30349:SF41">
        <property type="entry name" value="INTEGRASE_RECOMBINASE PROTEIN MJ0367-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30349">
        <property type="entry name" value="PHAGE INTEGRASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0229">DNA integration</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="5">
        <location>
            <begin position="106"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="332"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF83831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="403" mass="46868" checksum="D1FE4F3351B0CE47" modified="2014-10-29" version="1">MAKEYLGNVSARNAFSGRTYAQRIKRFEEFVAKDGIDATVAKLLKGKLDVYKVMSGFNAYMASRKVTPRSQVQTVKTVRNFLEYCDVPISKAKFKLKVFLPVIVRKQKKALSKAEVREIVMACRGDARLFTYVLFLAATGCRATEALNVRNKDLHLDDPIQPYVFIRGETTKTKQDRNVFLTTELIKALKEYLTVKYRERRTVYDRTLGKTIHNKFAPRQEDDDYVFVAYHQDRTIQPDLRSVYVHLNHAFVETLDRNGRGQKEENKRRRKITFHSLRRFVKTQISTLGYAEFSEYFIGHTSTVNMVYFAETHEKLVQIFKKCEPALTLLDVTSMEARQRDFETRLQKAEQEALDAKNSTAQMEQIIANMARLKGYKWTRDEFHQVFKGLLGEPEEEERADSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQR6</accession>
    <name>A0A075MQR6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative esterase of the alpha-beta hydrolase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_01490</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700302.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQR6"/>
    <dbReference type="STRING" id="1459636.NTE_01490"/>
    <dbReference type="GeneID" id="41597279"/>
    <dbReference type="KEGG" id="nev:NTE_01490"/>
    <dbReference type="HOGENOM" id="CLU_041386_0_0_2"/>
    <dbReference type="OrthoDB" id="11532at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF57">
        <property type="entry name" value="BLR7027 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="4">
        <location>
            <begin position="24"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF83553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="551" mass="63048" checksum="A57141843E6EA206" modified="2014-10-29" version="1">MQPESQSKTLRGNAGYVPKKQRALILQGGGALGAYEAGVFKALSERLSPLEDDRQEGGKRQHGNLFDIVAGASAGAINAALIVDHVVRNKKWEGASDVLWNFWQEISTPVFWPDNKWFSNGWQFWENARKWQSDFFGKFVLPNLPAGNLREENLFLPYYFLWPDNLGPLASEEAARRYWSWYQFAFMSGGTPHVLSPGIVQPDFRFNNPYNYLVRYSNAPLLMAIKKHWDYEKHSIKTSYDKNEPRLLFVSVDVKDAITATFDSYEKENGVWKTEYAHETAGDSSDDDNDGRKDTHVIEYEQGLGIGHLLTSISSHLRYRPPDLEATTITEEGRDRKSTTLKKKGVRYFWDGFYLSNTPLREVLQSHRDYWHKIRNHANTLSATTAAAISRAKETDAATVPNLEVYIVDLYPTVERDDFPRDPDGVQNRVGDILYHDKTKYDQKIAYLVTDYIDLANKLIRIAIEQAKDRNTAESEIRDFLETADPKSKKRNGKERKYGDLLGGRFDVEKVVRIELAADDKNDIYGKAFDFSSGTIKQLLDKGYSDALRYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQX0</accession>
    <name>A0A075MQX0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3-oxoacyl-[acyl-carrier-protein] reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01149</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700020.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQX0"/>
    <dbReference type="STRING" id="1459636.NTE_01149"/>
    <dbReference type="GeneID" id="41596960"/>
    <dbReference type="KEGG" id="nev:NTE_01149"/>
    <dbReference type="eggNOG" id="arCOG01259">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_2"/>
    <dbReference type="OrthoDB" id="24596at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005559">
        <property type="entry name" value="PRK07231.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="255" mass="27974" checksum="E437EB56C0DA659B" modified="2014-10-29" version="1">MRLLDGRVAIITGSTKGNGLAMANLFSEHGANVVITGRDEKEIQNAVNEILKEHQTEPLGLKVDVTSNQEVREMVTRVLQKYNQIDVLINNAGFPIRDELWDVSFEKISDQDLDRVLDVDTKGTYRCCREVLPVMQKQRYGVIINISSTPAISGYTKGAPYTVAKAANLGITKHIAAEYGKYNIRCNAIAPGTIATQRNWERLSDAERNELVSSIPLGRAGRPGEIAGVVLLLASDYSSFVNGQTIVIDGGETIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQY1</accession>
    <name>A0A075MQY1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CdvA-like coiled-coil domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_01446</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700270.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQY1"/>
    <dbReference type="STRING" id="1459636.NTE_01446"/>
    <dbReference type="GeneID" id="41597241"/>
    <dbReference type="KEGG" id="nev:NTE_01446"/>
    <dbReference type="eggNOG" id="arCOG04054">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082930_0_0_2"/>
    <dbReference type="OrthoDB" id="12104at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041461">
        <property type="entry name" value="CdvA_CC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18822">
        <property type="entry name" value="CdvA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CdvA-like coiled-coil" evidence="2">
        <location>
            <begin position="84"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF83510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="277" mass="30305" checksum="6A87BB73B51B242F" modified="2014-10-29" version="1">MSEEKLAFVGKQVKDIYGTFIGKVVGIITEIDGEIESVGVDCGSAGIKQLPYEQLVVQGDFVFFIPKWRLEAQKLIRQKSLTLKRIKALHEIVAENDGMKEDAELVSIKYEKKLNELNEAEKAVGDKLAARLAELDAEAKQVKAVLFDAKLQFRSNEMKEETYQQVKINTDELVEHINNERTEIGNVRAKLSGLTIDNITTDSAATTTPTAPTVDSVPATATTAEPASHSSTTADSHGEPVTATPAEEKPITVTASSNNNNEEGHDAAWLNQVIQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MR11</accession>
    <name>A0A075MR11_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribose 5-phosphate isomerase A</fullName>
            <ecNumber evidence="3">5.3.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_01476</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>aldehydo-D-ribose 5-phosphate = D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14657"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="EC" id="5.3.1.6"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.3.1.6" evidence="3"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MR11"/>
    <dbReference type="STRING" id="1459636.NTE_01476"/>
    <dbReference type="KEGG" id="nev:NTE_01476"/>
    <dbReference type="eggNOG" id="arCOG01122">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056590_1_0_2"/>
    <dbReference type="OrthoDB" id="19013at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004751">
        <property type="term" value="F:ribose-5-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006014">
        <property type="term" value="P:D-ribose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01398">
        <property type="entry name" value="RPI_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1360:FF:000001">
        <property type="entry name" value="Ribose-5-phosphate isomerase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004788">
        <property type="entry name" value="Ribose5P_isomerase_type_A"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001924">
        <property type="entry name" value="PRK00702.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00021">
        <property type="entry name" value="rpiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11934">
        <property type="entry name" value="RIBOSE-5-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11934:SF0">
        <property type="entry name" value="RIBOSE-5-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06026">
        <property type="entry name" value="Rib_5-P_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75445">
        <property type="entry name" value="D-ribose-5-phosphate isomerase (RpiA), lid domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="NCBIfam" id="TIGR00021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF83540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="225" mass="24575" checksum="3B1D67C5FA4A77F9" modified="2014-10-29" version="1">MLQDAIQKLAKDTVSKFVKPNQVVGLGSGSTAAYIVREMASLKAKDTLLCIPTSLQIKVEAEKSGLRFADESRIPDIDVVFDGADQIDGRFNMIKGGGGALLREKILISSAKTVVIVADEAKFVKSFSRSVPIEVHPMARTSVAKRLEKIGAKPAMRTLDKGYPFITENGNIILDTVFPSISDPERAELELKGIPGVMEVGMFTRKTNVYYYRAKSDGTFELVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MR20</accession>
    <name>A0A075MR20_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative ester cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01937</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MR20"/>
    <dbReference type="STRING" id="1459636.NTE_01937"/>
    <dbReference type="KEGG" id="nev:NTE_01937"/>
    <dbReference type="eggNOG" id="arCOG06513">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100997_5_2_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030638">
        <property type="term" value="P:polyketide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009959">
        <property type="entry name" value="Cyclase_SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38436:SF1">
        <property type="entry name" value="ESTER CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38436">
        <property type="entry name" value="POLYKETIDE CYCLASE SNOAL-LIKE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07366">
        <property type="entry name" value="SnoaL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="175" mass="19721" checksum="0B790A4CB9F909F0" modified="2014-10-29" version="1">MAEYWIISMSTQRQQVTEKNIEIARRSIQALNTGDVTKASEFMHPDYFNHESQASPERAKLRGPSEFIDTVQKLRAAFSDLHYEEQESIASNDKVVSIMTVTGRHTGDFFGIPPSGRSFSYQAAHIVRIADGKIIEHRAIRDDLKFMMQLGVIGAASPQYEPIFNAWKGMIKKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRB8</accession>
    <name>A0A075MRB8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02044</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRB8"/>
    <dbReference type="KEGG" id="nev:NTE_02044"/>
    <dbReference type="HOGENOM" id="CLU_2712613_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="72" mass="8023" checksum="78B2DA97B0B8B4B4" modified="2014-10-29" version="1">MLIKFWKCVMFLLMFNPIVTARVDDNVALLLAKIISACLLQIPHHAFELLSCDLALGVSFSEDRCGIVTVLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRD0</accession>
    <name>A0A075MRD0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA-binding protein involved in rRNA processing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_02054</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRD0"/>
    <dbReference type="STRING" id="1459636.NTE_02054"/>
    <dbReference type="KEGG" id="nev:NTE_02054"/>
    <dbReference type="eggNOG" id="arCOG02466">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_165890_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.230">
        <property type="entry name" value="Probable tRNA pseudouridine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038664">
        <property type="entry name" value="Gar1/Naf1_Cbf5-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF84111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="120" mass="13095" checksum="751CAFB7C3F6E4FF" modified="2014-10-29" version="1">MTEAYDSKEKLIVQMGEIGEVMHLAKSGRLIVKLNAAGATGIRPGEVLIDSAGRRVGRISELIGPVNAPYASVIPMTDRTARLTGAKVFAGGRPQQQTKTRPSSHGHKQHDKERRRGRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRD6</accession>
    <name>A0A075MRD6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02059</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRD6"/>
    <dbReference type="KEGG" id="nev:NTE_02059"/>
    <dbReference type="HOGENOM" id="CLU_2230466_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="85" mass="9748" checksum="FBBE56B0B535C3E8" modified="2014-10-29" version="1">MRESPESLIIPLETEELYPTIILELCDNCKWSCSCLSTTDTIESCPVCKAAIRSYVPMTSEEVSRIEIDDERGMILQFSRRMLVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRI1</accession>
    <name>A0A075MRI1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10 11">Quinolinate synthase</fullName>
            <ecNumber evidence="2 10 11">2.5.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">nadA</name>
        <name evidence="12" type="ORF">NTE_01702</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>iminosuccinate + dihydroxyacetone phosphate = quinolinate + phosphate + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25888"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29959"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
            <dbReference type="EC" id="2.5.1.72"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="10">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from iminoaspartate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the quinolinate synthase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.72" evidence="2 10 11"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700473.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRI1"/>
    <dbReference type="STRING" id="1459636.NTE_01702"/>
    <dbReference type="GeneID" id="41597472"/>
    <dbReference type="KEGG" id="nev:NTE_01702"/>
    <dbReference type="eggNOG" id="arCOG04459">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047382_0_0_2"/>
    <dbReference type="OrthoDB" id="5931at2157"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00327"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008987">
        <property type="term" value="F:quinolinate synthetase A activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034628">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-aspartate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Quinolinate synthase A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NadA-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00568">
        <property type="entry name" value="NadA_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003473">
        <property type="entry name" value="NadA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036094">
        <property type="entry name" value="NadA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023066">
        <property type="entry name" value="Quinolinate_synth_type2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00550">
        <property type="entry name" value="nadA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006878">
        <property type="entry name" value="PRK09375.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006879">
        <property type="entry name" value="PRK09375.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30573:SF0">
        <property type="entry name" value="QUINOLINATE SYNTHASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30573">
        <property type="entry name" value="QUINOLINATE SYNTHETASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02445">
        <property type="entry name" value="NadA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142754">
        <property type="entry name" value="NadA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 10" id="KW-0408">Iron</keyword>
    <keyword evidence="9 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10 12" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="10">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="114"/>
            <end position="116"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="201"/>
            <end position="203"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="NCBIfam" id="TIGR00550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIF83763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="316" mass="35004" checksum="A3BCBC27A17BA149" modified="2014-10-29" version="1">MTMLAIDFKEQVLRLKKERNAIILAHNYQLPEVQDVADFIGDSLALSKNAAATDADVIVFCGVHFMAETASILCPNKKVLIPDLEAGCSLASTINADELAAWKQEHPDAVVVSYVNTTAEVKALSDYCCTSSNAVKVVNSIPADRKVLFLPDMFLGSYVAEVTKRKNMYIWPGECHVHAGIKAEDINKMLATLKNADFLVHPECSCTSSTMYHMAKGDLAQKGHILSTEGMMKHARTSGAKQFVVATETGILYRMRKENPDKEFIPVKEDATCRYMKKITLEKVYNSLAHNVYEVKVPKQVADKARLAIDRMLAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRK1</accession>
    <name>A0A075MRK1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01374</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
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    </dbReference>
    <dbReference type="RefSeq" id="WP_148700212.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
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    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="191" mass="21266" checksum="3C7A7FF42B40BC14" modified="2014-10-29" version="1">MMLKSIVVVVGIVFLLTPSTVALAVPTFGNTTYTTNGKAIISTKQQSSVQSLRTMMTTISNQTAAQIIANSHLPGIGKDSIIRTIQFQYWKYNGTIPWANDTVSQYVIYIANPATLAVNWTDTRPFIGNYGDHAFFISKNDTSDKYIWVVTDKTDKEKYEAPAPRYFYLYYVDAFSGKILAYDCACCGVCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRY3</accession>
    <name>A0A075MRY3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01514</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="WP_148700323.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
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    <dbReference type="STRING" id="1459636.NTE_01514"/>
    <dbReference type="GeneID" id="41597302"/>
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    <dbReference type="HOGENOM" id="CLU_2433698_0_0_2"/>
    <dbReference type="OrthoDB" id="8375at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="90" mass="10398" checksum="4F17539BC4EAA8B1" modified="2014-10-29" version="1">MIYRCSDGHISFAKEPLLHCGMKGCENSADAVSTVDIEWFYRISPSGLAINEQDLHMILKDRNMPQDVKDRVREIFPAVPEKKKRFFGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MS30</accession>
    <name>A0A075MS30_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phage integrase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_01855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700600.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MS30"/>
    <dbReference type="GeneID" id="41597618"/>
    <dbReference type="KEGG" id="nev:NTE_01855"/>
    <dbReference type="eggNOG" id="arCOG01245">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_629472_0_0_2"/>
    <dbReference type="OrthoDB" id="12201at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00397">
        <property type="entry name" value="DNA_BRE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="2">
        <location>
            <begin position="151"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF83915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="435" mass="49764" checksum="377C44FE9F46328C" modified="2014-10-29" version="1">MALIVEAKGAYQRFLSKTRNDFTRRQYDHFLTTFIEFTLKVKVDSPKLQELKKEFTKNRHKEKATKEALKKSILEEKIRIMEPLVAQITELPITSLEDLIIDFINYLSGIGRGYGSQIAVVNAMRKFCKANKIVLDFDGLREAVGEDDTERDDKPYSKDMVQRVMQAADLRKQTIIGILASCGMRRGGLADLKLKHLTKLSVDNWPTVYALKVYPNSARSCYTTFVTPEVTAIIDQYLESRRAAGETLNEESPLLREQFAIESADNPRHITTGTIAQLVHQVIEDAGLKGELRKNKIHEMHGFRKHVYTELIKAGVKDINVKRIVGHSTGLGKNYDRQELEDVLRDYMKALPALTISDAPVLRAELEKMKIQNADIDILKIKVSQQADDLRVMQSILERYAKGEIQQPPKRSPEEERDYLEWLLRDYEKEHGGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MS37</accession>
    <name>A0A075MS37_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01919</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700643.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MS37"/>
    <dbReference type="GeneID" id="41597667"/>
    <dbReference type="KEGG" id="nev:NTE_01919"/>
    <dbReference type="HOGENOM" id="CLU_1943925_0_0_2"/>
    <dbReference type="OrthoDB" id="10263at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="130" mass="14211" checksum="B22CA29F8C22CE4B" modified="2014-10-29" version="1">MHDSTPSAARQQRGKAAIDAAHAGIAREDEGKVSALISDSYGVDNVEALDIHTNYHAERIMSALEKRARENGMGKDAFDAKVQELDVASQAYQVATGQLAEAAAVDIMFRNLYRMESKGGENDRYVNFYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MS48</accession>
    <name>A0A075MS48_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">3-oxoacyl-[acyl-carrier-protein] reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_01929</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226986924.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MS48"/>
    <dbReference type="STRING" id="1459636.NTE_01929"/>
    <dbReference type="GeneID" id="41597677"/>
    <dbReference type="KEGG" id="nev:NTE_01929"/>
    <dbReference type="eggNOG" id="arCOG01259">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05362">
        <property type="entry name" value="THN_reductase-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009385">
        <property type="entry name" value="PRK12744.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE-LIKE PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107:SF7">
        <property type="entry name" value="RE15974P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF83988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="258" mass="28269" checksum="9A9950CE25562704" modified="2014-10-29" version="1">MTTTKSEMKKSLAGKVAIVTGASQNLGRAYAEMLGMEGVFVVVRYHGESKKSDAEDVATNIRKAGSKAIIEQADLTKTAEIKRLFDRTMEEFGRLDILINTAGKVLKKPFVDISEEEYDSMFAVNAKAAFFCMQEAAKRMANNGRIINMETSLVGATTPYYSAYAGSKAPLEDFARALAKEIGNRGITVNNIAPGPLNTSFFYPAETKESTEYFKQQSINGQLGEIRDIVPLAKFLVSPEASWVTAQTIFINGGFLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSC1</accession>
    <name>A0A075MSC1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00167</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158384894.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSC1"/>
    <dbReference type="STRING" id="1459636.NTE_00167"/>
    <dbReference type="GeneID" id="43502538"/>
    <dbReference type="KEGG" id="nev:NTE_00167"/>
    <dbReference type="HOGENOM" id="CLU_3038859_0_0_2"/>
    <dbReference type="OrthoDB" id="379386at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="54" mass="6438" checksum="D99AC210E20F7A46" modified="2014-10-29" version="1">MNRANEFEKLNERKEQYVIVDDDTIIHLKNYYRLEGHDELLQFIKDAVIVGDEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSK0</accession>
    <name>A0A075MSK0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00242</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699331.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSK0"/>
    <dbReference type="STRING" id="1459636.NTE_00242"/>
    <dbReference type="GeneID" id="41596157"/>
    <dbReference type="KEGG" id="nev:NTE_00242"/>
    <dbReference type="HOGENOM" id="CLU_184936_0_0_2"/>
    <dbReference type="OrthoDB" id="9475at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="83" mass="9307" checksum="0E943B641983CA4B" modified="2014-10-29" version="1">MNIENEAGNIVIAKTYNSSTNNGRKVSYAFVDQAHALCLDKKDIIIAEIEACERLLKYAENESDQETVKNELSELKMALDLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MST1</accession>
    <name>A0A075MST1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02149</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700819.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MST1"/>
    <dbReference type="STRING" id="1459636.NTE_02149"/>
    <dbReference type="GeneID" id="41597874"/>
    <dbReference type="KEGG" id="nev:NTE_02149"/>
    <dbReference type="HOGENOM" id="CLU_148456_0_0_2"/>
    <dbReference type="OrthoDB" id="12159at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="151" mass="15365" checksum="2915D42CE8B64318" modified="2014-10-29" version="1">MPEQRSSSNVVPGAPRYGIAAGLAIHLTGFALGVISIGLVLGGVISIESGLATLTPFADALYGLGLVAVVAVAARAGVPMKYLLVAGAVIGVGLFYKSAPHEIHMASGIGFGLSHNGHIVVGTILITISVVALAVLAFVHNRSKQQEERMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSX1</accession>
    <name>A0A075MSX1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700876.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSX1"/>
    <dbReference type="GeneID" id="41597937"/>
    <dbReference type="KEGG" id="nev:NTE_02216"/>
    <dbReference type="eggNOG" id="arCOG10514">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_145187_0_0_2"/>
    <dbReference type="OrthoDB" id="9099at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="151" mass="17078" checksum="EBF8A0291D9C1CD8" modified="2014-10-29" version="1">MPRAKKTAEAQSNEEGLPKWAEDEIKSAQFGKPEVVTRTGYILEIYEKDYRLDIQVYEPMPDGRVIIEGISLPKEVKINDLMKGFVYEFKINVYTAPLSDKVTELLKTKFNLDMKAIFNFEMKELALMDVESDMPAPSSSSAGEDGEGDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSX9</accession>
    <name>A0A075MSX9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01837</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700585.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSX9"/>
    <dbReference type="STRING" id="1459636.NTE_01837"/>
    <dbReference type="GeneID" id="41597601"/>
    <dbReference type="KEGG" id="nev:NTE_01837"/>
    <dbReference type="eggNOG" id="arCOG04069">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017233_1_0_2"/>
    <dbReference type="OrthoDB" id="4144at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd18086">
        <property type="entry name" value="HsC9orf114-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003750">
        <property type="entry name" value="Put_MeTrfase-C9orf114-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12150">
        <property type="entry name" value="CLASS IV SAM-BINDING METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12150:SF13">
        <property type="entry name" value="METHYLTRANSFERASE C9ORF114-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02598">
        <property type="entry name" value="Methyltrn_RNA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="280" mass="31460" checksum="967F959C1CCD79DE" modified="2014-10-29" version="1">MQNLWVAIPDSSLSDEQTKRDKSIKIAQFARACSIFRAKRIYIYHDPLSQFEKEDPILLRTVLRYLDTPQYLRKILYPKMTQLEFAGILHPIKAPHHRPAQDIKTVRAGDVRTGVIAKVKGALFVEAGLGSLVPFEGQGFEGKKVNVKFTQPYPNLRAVEATDHDISDYWGYEVKEVPSVVKLLSSSMEKTVAVITSRKGSYFKNVEVKLGERIRANENVLVVFGAPRHGVHEIIAKEGTNVRAEFVVNMFPNQATETVRLEEAILGTLAILNSSILSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MT25</accession>
    <name>A0A075MT25_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02668</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701233.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MT25"/>
    <dbReference type="STRING" id="1459636.NTE_02668"/>
    <dbReference type="GeneID" id="41598359"/>
    <dbReference type="KEGG" id="nev:NTE_02668"/>
    <dbReference type="eggNOG" id="arCOG00731">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_153620_0_0_2"/>
    <dbReference type="OrthoDB" id="35765at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38600">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38600:SF1">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="61"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="138" mass="15131" checksum="3A95C145E336C078" modified="2014-10-29" version="1">MFLTAGISGIIAGLLVTLRLPSSSFLHAAPGGFAGQGGGYIDPRFKRVLWYLIASSRGGANRAKIIDMLNGRPANANQIASELKLDYKTVLHHLKVLTENGMIITENRETYGATYFLTPLMEKNYASFQEILAKVKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MT29</accession>
    <name>A0A075MT29_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02214</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700874.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MT29"/>
    <dbReference type="STRING" id="1459636.NTE_02214"/>
    <dbReference type="GeneID" id="41597935"/>
    <dbReference type="KEGG" id="nev:NTE_02214"/>
    <dbReference type="eggNOG" id="arCOG08684">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_157016_0_0_2"/>
    <dbReference type="OrthoDB" id="373627at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="129" mass="14556" checksum="A4025E92BA0911F6" modified="2014-10-29" version="1">MRNINPAGRCDFQAADYAGICKALVALHGNIQAAVVVSRGEMKARYVRQGVPIPPARELEKLFVRAEVFASMTKESDHLFGRTGYVMTSYEMLDTFIFSMHDDSVMILPITKPYNHDELLDKVKSLLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MT50</accession>
    <name>A0A075MT50_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Flagellin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NTE_02338</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Archaeal flagellum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the archaeal flagellin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700971.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MT50"/>
    <dbReference type="GeneID" id="41598054"/>
    <dbReference type="KEGG" id="nev:NTE_02338"/>
    <dbReference type="eggNOG" id="arCOG01829">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084671_0_0_2"/>
    <dbReference type="OrthoDB" id="12034at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097589">
        <property type="term" value="C:archaeal-type flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097588">
        <property type="term" value="P:archaeal or bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013373">
        <property type="entry name" value="Flagellin/pilin_N_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002774">
        <property type="entry name" value="Flagellin_arc-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02537">
        <property type="entry name" value="arch_flag_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35903">
        <property type="entry name" value="FLAGELLIN B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35903:SF1">
        <property type="entry name" value="FLAGELLIN B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01917">
        <property type="entry name" value="Flagellin_arch-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0974">Archaeal flagellum</keyword>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="6" id="KW-0282">Flagellum</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF84390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="225" mass="23945" checksum="7296266F3192AF56" modified="2014-10-29" version="1">MKKSKQRQKLRRGVIGIESAIVLIAFVMVAAALSFVILNMGFSTTQKAKTTIASGLDEASSAMEITGGVTGHGNVTQNRLTYYAVPIKVSPGGQSVNVETGNTAIRYYSKNLVFESTYRGILTNGTYSNSTAAIVAAKNAGMINQLPWAGNGLNETSAIVYFTVNKNNNSILDIGENAVVLMMFKNSDRPTSLDTVNTEVIVPTGALLSVKRMVPSISDTVVELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MT58</accession>
    <name>A0A075MT58_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00422</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699462.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MT58"/>
    <dbReference type="STRING" id="1459636.NTE_00422"/>
    <dbReference type="GeneID" id="41596301"/>
    <dbReference type="KEGG" id="nev:NTE_00422"/>
    <dbReference type="eggNOG" id="arCOG08799">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2534842_0_0_2"/>
    <dbReference type="OrthoDB" id="6023at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="84" mass="9424" checksum="A66DB77E12F8A76A" modified="2014-10-29" version="1">MDAYLEEELYDLLTFCIQNPSATSDIASKKGRVAEIGRELAADGGADAMENMFFAIENRIQGEIGADARPYRAWWNGIASEWKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MT81</accession>
    <name>A0A075MT81_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 6">Shikimate dehydrogenase (NADP(+))</fullName>
            <shortName evidence="6">SDH</shortName>
            <ecNumber evidence="1 6">1.1.1.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">aroE</name>
        <name evidence="10" type="ORF">NTE_01954</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>shikimate + NADP(+) = 3-dehydroshikimate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17737"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the shikimate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.25" evidence="1 6"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226986927.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MT81"/>
    <dbReference type="STRING" id="1459636.NTE_01954"/>
    <dbReference type="GeneID" id="41597701"/>
    <dbReference type="KEGG" id="nev:NTE_01954"/>
    <dbReference type="eggNOG" id="arCOG01033">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044063_4_1_2"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00087"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019632">
        <property type="term" value="P:shikimate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01065">
        <property type="entry name" value="NAD_bind_Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00222">
        <property type="entry name" value="Shikimate_DH_AroE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041121">
        <property type="entry name" value="SDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011342">
        <property type="entry name" value="Shikimate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022893">
        <property type="entry name" value="Shikimate_DH_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006151">
        <property type="entry name" value="Shikm_DH/Glu-tRNA_Rdtase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00507">
        <property type="entry name" value="aroE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001319">
        <property type="entry name" value="PRK00258.3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089:SF1">
        <property type="entry name" value="BIFUNCTIONAL 3-DEHYDROQUINATE DEHYDRATASE_SHIKIMATE DEHYDROGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089">
        <property type="entry name" value="SHIKIMATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18317">
        <property type="entry name" value="SDH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01488">
        <property type="entry name" value="Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0521">NADP</keyword>
    <keyword evidence="4 6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shikimate dehydrogenase substrate binding N-terminal" evidence="8">
        <location>
            <begin position="14"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase" evidence="7">
        <location>
            <begin position="127"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="SDH C-terminal" evidence="9">
        <location>
            <begin position="247"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="22"/>
            <end position="24"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="132"/>
            <end position="136"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIF84012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="284" mass="30520" checksum="7E457A2DC2F44232" modified="2014-10-29" version="1">MMTGERAPAKTYCIIGDPISHSLSPGMQNAAFSALGLNCTYISFRVPAPDLKESIDSLRAINVAGFNVTIPHKVAVIKYLDELDVTAKKAGAVNTVNNIEGILKGYNTDIAGFIEPLRRREFDFGITILLLGAGGAARAIIAALSEEKKTGRVIIANRDQAKAKELARIAGDLGIQCETIALEDAVQVSPEAGLIVNATSIGLDNEPSPIDSDHIKKGSLVYDIVYRPVVTDLLEQAKFAQAHVVYGYEMLLEQGAKAFEIWTGLPAPRDVMKKNLLGIFGEPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTD8</accession>
    <name>A0A075MTD8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-type polysaccharide/polyol phosphate export systems, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NTE_02000</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700706.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTD8"/>
    <dbReference type="STRING" id="1459636.NTE_02000"/>
    <dbReference type="GeneID" id="41597747"/>
    <dbReference type="KEGG" id="nev:NTE_02000"/>
    <dbReference type="eggNOG" id="arCOG01469">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096331_0_0_2"/>
    <dbReference type="OrthoDB" id="97972at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047817">
        <property type="entry name" value="ABC2_TM_bact-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051784">
        <property type="entry name" value="Nod_factor_ABC_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43229:SF3">
        <property type="entry name" value="ABC-TYPE MULTIDRUG TRANSPORT SYSTEM, PERMEASE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43229">
        <property type="entry name" value="NODULATION PROTEIN J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-2" evidence="6">
        <location>
            <begin position="17"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF84057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="248" mass="26976" checksum="68525315A6352DFB" modified="2014-10-29" version="1">MSAMLPVRQACLIAYSTGILWLQRNPMSLVFTAISPFSLLFVLFVVSNGQYTHYAVAGSLVMALVGYGLALGQDISFYKTEYKIQDIFVASPVSPLTYMMGLALSELLFGLPALTVLAALVVYFGAPLTAIPLLIATIVLLWSSMSAMGFFLSSHMLHMRNATQVISFVNVVLAVLPPIFYPVTNLPSDSLRYLSYAVPTTHASIMFQDIMGLPTPADWSLGLGFAVQVAYLVGFVTLAKTKAIWREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTE8</accession>
    <name>A0A075MTE8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative stress protein (General stress protein 26)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_02831</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_264357914.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTE8"/>
    <dbReference type="STRING" id="1459636.NTE_02831"/>
    <dbReference type="GeneID" id="41598515"/>
    <dbReference type="KEGG" id="nev:NTE_02831"/>
    <dbReference type="eggNOG" id="arCOG00516">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140794_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070967">
        <property type="term" value="F:coenzyme F420 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052019">
        <property type="entry name" value="F420H2_bilvrd_red/Heme_oxyg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35176">
        <property type="entry name" value="HEME OXYGENASE HI_0854-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35176:SF6">
        <property type="entry name" value="HEME OXYGENASE HI_0854-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="PNPOx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine 5'-phosphate oxidase N-terminal" evidence="2">
        <location>
            <begin position="3"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF84871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="118" mass="13441" checksum="6F022110D298A9BA" modified="2014-10-29" version="1">MHPVWYYFDGYKLYFETSQNSRKAQNIRNRGAVYFCIDDESVPYKGVRGKGIATISEDVNRNVPFAEKLVVKYTGSLENKIAKFLMHSIRSGESVIIEISPLYFATWDQSKGTSVAMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTI1</accession>
    <name>A0A075MTI1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ni,Fe-hydrogenase III small subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NTE_02455</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I 20 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_193354072.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTI1"/>
    <dbReference type="STRING" id="1459636.NTE_02455"/>
    <dbReference type="GeneID" id="41598162"/>
    <dbReference type="KEGG" id="nev:NTE_02455"/>
    <dbReference type="eggNOG" id="arCOG01543">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG01553">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055737_5_1_2"/>
    <dbReference type="OrthoDB" id="5740at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052375">
        <property type="entry name" value="Complex_I_20kDa-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006138">
        <property type="entry name" value="NADH_UQ_OxRdtase_20Kd_su"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005012">
        <property type="entry name" value="PRK06411.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42989:SF1">
        <property type="entry name" value="FORMATE HYDROGENLYASE SUBUNIT 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42989">
        <property type="entry name" value="HYDROGENASE-4 COMPONENT I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56770">
        <property type="entry name" value="HydA/Nqo6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01150">
        <property type="entry name" value="COMPLEX1_20K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="75"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF84505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="277" mass="29584" checksum="6718BF5DEB7F6A1F" modified="2014-10-29" version="1">MIGKIGKRANSGSADIVGNSIETVGDPIKDIHAFPNYRGRVSLAEKAGLPLENYEAAEEICASGAIKIQACGDKEKITLDMGKCFLCGRCQEVAPDLLRVESAFAIPVRKREELIESLDGIAPAEESFEKMGKELKEKVGKILGRSLAVREVDAGSCNGCEVEITALNNPVYDIERFGIHFVASPRHADVLLVTGPASRNMEVALKRTYEATPDPKIVVAVGACGCSGGIFGDTYATTGGIDKMVPVDVYIPGCPPRPEAILYGLLLAVDRIPEKHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTM8</accession>
    <name>A0A075MTM8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nitrososphaera output domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701100.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTM8"/>
    <dbReference type="GeneID" id="41598200"/>
    <dbReference type="KEGG" id="nev:NTE_02496"/>
    <dbReference type="HOGENOM" id="CLU_160434_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041226">
        <property type="entry name" value="NitrOD2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18550">
        <property type="entry name" value="NitrOD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitrososphaera output" evidence="1">
        <location>
            <begin position="15"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="114" mass="12865" checksum="4B1BA997FCF5C430" modified="2014-10-29" version="1">MYFTIFGDRLMSQTNISIIADAMLQNLRESLGAEAYDIVMSRIVKDYFGEKIDIHTAIIQRPEVFESAFVDLLGQMGRILLTKLLDDICPESIIDLHYSKAGDFAKYVVAIQNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTP3</accession>
    <name>A0A075MTP3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Large ribosomal subunit protein eL31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpl31e</name>
        <name evidence="7" type="ORF">NTE_02464</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the eukaryotic ribosomal protein eL31 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701075.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTP3"/>
    <dbReference type="STRING" id="1459636.NTE_02464"/>
    <dbReference type="GeneID" id="41598171"/>
    <dbReference type="KEGG" id="nev:NTE_02464"/>
    <dbReference type="eggNOG" id="arCOG04473">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112570_3_0_2"/>
    <dbReference type="OrthoDB" id="10127at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00463">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00410">
        <property type="entry name" value="Ribosomal_eL31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000054">
        <property type="entry name" value="Ribosomal_eL31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020052">
        <property type="entry name" value="Ribosomal_eL31_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023621">
        <property type="entry name" value="Ribosomal_eL31_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002258">
        <property type="entry name" value="PRK01192.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10956">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10956:SF0">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01198">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01380">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54575">
        <property type="entry name" value="Ribosomal protein L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01144">
        <property type="entry name" value="RIBOSOMAL_L31E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="85"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="112"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF84513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="126" mass="14187" checksum="406B773C6B45A76C" modified="2014-10-29" version="1">MSEENVTRVYTINLGRAWLTPEHKRTDRVVNMIREFAEKHMKSGDVKLDQDLNRQIWSRGKTNPPRKVRVKMVKDEDDVVTVSLYEEPTESAPTPAPAATEAPAAATAEAKPATEETKAEEQPKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTX2</accession>
    <name>A0A075MTX2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03067</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTX2"/>
    <dbReference type="KEGG" id="nev:NTE_03067"/>
    <dbReference type="HOGENOM" id="CLU_181205_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="99" mass="11430" checksum="ECBABDC41419A798" modified="2014-10-29" version="1">MTINLMLWVENGLINILIRTNVAERRSDKNTVTFTKSFHKFVMRNLHGDAAVLTPQECQKILCQYHRALASITFDQVLATMVIFGFYFDQIEIPIPDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MU10</accession>
    <name>A0A075MU10_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">4-phosphopantoate--beta-alanine ligase</fullName>
            <ecNumber evidence="5">6.3.2.36</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Phosphopantothenate synthetase</fullName>
            <shortName evidence="5">PPS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NTE_02600</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the condensation of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(R)-4-phosphopantoate + beta-alanine + ATP = (R)-4'-phosphopantothenate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27930"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="ChEBI" id="CHEBI:61294"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.2.36"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; coenzyme A biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal phosphopantothenate synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.36" evidence="5"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701177.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MU10"/>
    <dbReference type="STRING" id="1459636.NTE_02600"/>
    <dbReference type="GeneID" id="41598293"/>
    <dbReference type="KEGG" id="nev:NTE_02600"/>
    <dbReference type="eggNOG" id="arCOG04262">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078701_0_0_2"/>
    <dbReference type="OrthoDB" id="10078at2157"/>
    <dbReference type="UniPathway" id="UPA00241"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016881">
        <property type="term" value="F:acid-amino acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12640">
        <property type="entry name" value="Phosphopantoate/pantothenate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02224">
        <property type="entry name" value="PPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002855">
        <property type="entry name" value="PPS/PS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038138">
        <property type="entry name" value="PPS/PS_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041123">
        <property type="entry name" value="phpantohe_syn_Arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010324">
        <property type="entry name" value="PRK13761.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40695">
        <property type="entry name" value="4-PHOSPHOPANTOATE--BETA-ALANINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40695:SF1">
        <property type="entry name" value="4-PHOSPHOPANTOATE--BETA-ALANINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02006">
        <property type="entry name" value="PPS_PS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004853">
        <property type="entry name" value="UCP004853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="1 5 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="185"/>
            <end position="187"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="191"/>
            <end position="192"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="203"/>
            <end position="204"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF84643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="251" mass="27099" checksum="26E44CF35EA2A5E6" modified="2014-10-29" version="1">MTITTIPADHPRAKSLHTREMLVDGFKRNLVVAEGLIAHGRGEAFDYLIGERTSAAAKKAIRAAAAALLLSNKKAVLSVNGNAAALCPKEIVELSKITGAAIEVNLFYRTEEREYAIKAELEKHGARNVLGVGPRASAKIPELSSERRRVDPDGIFSADTVFVPLEDGDRTEALARMGKTVITVDLNPLSRTAKAAHVTMVDNLVRAMPALVQEAQALKGKDAKSLERMVRAFDNKKNLAQSLKKIRGGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MU41</accession>
    <name>A0A075MU41_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ADP-ribose pyrophosphatase</fullName>
            <ecNumber evidence="3">3.6.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_02647</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.1.-" evidence="3"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701216.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MU41"/>
    <dbReference type="STRING" id="1459636.NTE_02647"/>
    <dbReference type="GeneID" id="41598339"/>
    <dbReference type="KEGG" id="nev:NTE_02647"/>
    <dbReference type="eggNOG" id="arCOG01075">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037162_20_3_2"/>
    <dbReference type="OrthoDB" id="40462at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18873">
        <property type="entry name" value="NUDIX_NadM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43736">
        <property type="entry name" value="ADP-RIBOSE PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43736:SF1">
        <property type="entry name" value="DIHYDRONEOPTERIN TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="6"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF84690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="154" mass="17345" checksum="9DD71E601191505F" modified="2014-10-29" version="1">MSSYRNPTPTVDAILQKGSKVLMVRRKKDPFKDTLALPGGFVNEGETVEDAMKREVMEETALEVEPIDILGVYSDPHRDPRMHTMTVVFVAIIIGGKEKAQDDAASLEWVELAGIEKAAFDHAQILADYRQWKGNAGSTYWSTKRRSTQVDRNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MU95</accession>
    <name>A0A075MU95_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA (guanine(46)-N(7))-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NTE_00832</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>guanosine(46) in tRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42708"/>
            <dbReference type="Rhea" id="RHEA-COMP:10188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10189"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74480"/>
            <dbReference type="EC" id="2.1.1.33"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.1.1.33" evidence="2"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MU95"/>
    <dbReference type="STRING" id="1459636.NTE_00832"/>
    <dbReference type="KEGG" id="nev:NTE_00832"/>
    <dbReference type="eggNOG" id="arCOG08801">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_359698_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008176">
        <property type="term" value="F:tRNA (guanine(46)-N7)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003358">
        <property type="entry name" value="tRNA_(Gua-N-7)_MeTrfase_Trmb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02390">
        <property type="entry name" value="Methyltransf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="HD/PDEase" evidence="8">
        <location>
            <begin position="369"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF82909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="808" mass="92135" checksum="359BD1BE4A9487A9" modified="2014-10-29" version="1">MDRPGLKIYRQAGILGSKPGNSFSVSCSSRVYGRRNTRHLLPFSLHYHDAARWLFTLLLFSGLLSTGWFGIPLIPRYFIGTADIISGIFALFSALGAIWGIMAYREFTKSSSAVIDARLAARRLDPMIGDYEYKSYNPMTREYDDGFVPSGPVDFWDKETTVPAWMDKGKYWHILLSLQSSGREIRLQVVRDRDLPFGTGMRNVAVTSKDQSDEGRIMNRYIVKIPQWLVMNTERRRFSEHEAEGPELSALIADVNRKIVAATNEVAGWERLRVRYPWRFMTFAIYLNKSLPLRIVYRQVIRNFPGAKERKIYETNANLANVGDDELVASIVELAQRKKIPPARRAQIQTLMRFLKNAYTRQGLGEGASEYHNFHHSLEVAYVAMQLLPDYFRGYEFGPKDYELLLVAALLHDYDPAQELGSNSGKPKGPSAARTVEEVQKTRIHDAYFTMTNAEFEDYFRQYKSSSESLRPPEDYATTHPERVKSDWTPTESLIIETLIWRTDFPFFKQKLAQEKYSALLSQLKDNGKVNLLAEVLWLADLSVTYMVSDPVRAWDRVNNLYDELFLPKLEAVSRTDAFFADFADLPLYKELLSQRGFPDVFRRRWSLIYQFFHEGNPSTPLNRTIEMARKIYFKVNMELGMRHGEMLQEIASDNWSEYFIGIGKDQGEVLKAKSRLAQLDPQNASAFWGDVQKLLPSIPDGTIDNFLVVMPARVEPLATQEEKAKMETMLSVLVKKLAPGGTVKVLTDIEASSLQLKELMYAAGRAGLVPSDAGKQYFPAGWTDPDFLEKPHIVTLVPRPAAVATKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUB9</accession>
    <name>A0A075MUB9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02258</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385413.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUB9"/>
    <dbReference type="GeneID" id="43502642"/>
    <dbReference type="KEGG" id="nev:NTE_02258"/>
    <dbReference type="HOGENOM" id="CLU_2930029_0_0_2"/>
    <dbReference type="OrthoDB" id="13672at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="51" mass="5901" checksum="D5F924D430320F08" modified="2014-10-29" version="1">MEKKEGATYDRHKLIELGINPELLKDLNDEQAKELLKAIIYLIVKKQDGYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUI9</accession>
    <name>A0A075MUI9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02741</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUI9"/>
    <dbReference type="KEGG" id="nev:NTE_02741"/>
    <dbReference type="HOGENOM" id="CLU_1507322_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="178" mass="18715" checksum="2E95ACEB99F5F6D8" modified="2014-10-29" version="1">MIIGAVLITGGVAIGGVTGWLIEKSMLAGLPDVATQNTLGPGENITRTIMAKTGESFTVIARTPSPSHTIATIVYGPDGKIVLQSQGQEANPVLAIKDGPHVVTVRNEGSEPVTTTLLVFRVGVFSDNSVEFSPFLKQVFSFLGYIVLAGVLVLAGIIVLIIGAVKYFRERKRPAVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUK4</accession>
    <name>A0A075MUK4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative Fe-S oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NTE_02319</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_193354069.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUK4"/>
    <dbReference type="STRING" id="1459636.NTE_02319"/>
    <dbReference type="GeneID" id="41598035"/>
    <dbReference type="KEGG" id="nev:NTE_02319"/>
    <dbReference type="eggNOG" id="arCOG00933">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023791_0_0_2"/>
    <dbReference type="OrthoDB" id="49555at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034471">
        <property type="entry name" value="GDGT/MA_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034474">
        <property type="entry name" value="Methyltransferase_Class_D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056488">
        <property type="entry name" value="Zn_ribbon_HMPTM"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF045702">
        <property type="entry name" value="rSAM_GDGT_ether"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43306">
        <property type="entry name" value="7,8-DIHYDRO-6-HYDROXYMETHYLPTERIN DIMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43306:SF1">
        <property type="entry name" value="7,8-DIHYDRO-6-HYDROXYMETHYLPTERIN DIMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23545">
        <property type="entry name" value="Zn_ribbon_HMPTM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00385">
        <property type="entry name" value="7_8-dihydro-6-hydroxymethylpte"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01100">
        <property type="entry name" value="methyltransferase_(Class_D)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01067">
        <property type="entry name" value="SPASM/twitch_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="104"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF84372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="567" mass="65029" checksum="ABB6CA78C363B43B" modified="2014-10-29" version="1">MELIHISNMSSKNVAARKTIRFTQSICPDCNMILDAEVFEREGKVFMSKTCPTHGETEELYFGSYEMYKKFSTYWMDGKGAHAPNVMIDKCACPNNCGLCTNHLSHSGLSNMIITNRCDLTCWYCFFYVKKGLEGAYLYEPNHEQVRAMMKTLKAEKPIAGNSIQITGGEPMLRDDITELIKIMKEEGVDHVQLNTNGIKLAMSPETMRQVRNSGVSNLYLSFDGVTPRTNPKNHWEIPYTLESARKCGMTVVFVPTVIKSINDHELGGIIRYAQKHMDVVHAVNFQPVSLTGRMGKKEREKYRITIPDCIERIEEQTNGEISKDAWFPVPSCMPMTNIIEAFSKKPKYELSIHFACGAGTYVFEDTQTRKLTPLTAFVDIKGVLEYFEEKADEIRSGANRYWTMLEVVRKLKTFVDKDKQPHGLDLAKMFSSILLKRNFDSVGNWHVRSLFLGMMHFQDKYNEDLERLQRCDIHYLTPDLRIIPFCAFNVIPEWYRDRIQKKYSIPVEEWEQAHGQTLEAGLYRGLMRRGKPEAQMGCALSEMHREAAMANDDHKGVELRNNMAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUN6</accession>
    <name>A0A075MUN6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ASCH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03353</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701796.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUN6"/>
    <dbReference type="STRING" id="1459636.NTE_03353"/>
    <dbReference type="GeneID" id="99755956"/>
    <dbReference type="KEGG" id="nev:NTE_03353"/>
    <dbReference type="HOGENOM" id="CLU_137806_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.30">
        <property type="entry name" value="Hypothetical protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007374">
        <property type="entry name" value="ASCH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04266">
        <property type="entry name" value="ASCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ASCH" evidence="1">
        <location>
            <begin position="60"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="191" mass="22336" checksum="B5A52F790D539B2F" modified="2014-10-29" version="1">MREWSLNVLISPSWSADIHTELVRFLSTSVSEDNYWGQYLTPLLKKRSDLPFSLHLAVLVEPYLQFILEGKKTVESRFSSHRVAPYQKVANGDVILLKRSGGPIMGICEVTEVWYYRLDPRSWLDIKREFTNYLCVQDPSFWSDRKHASFATLMRIDKVATLGPLFIEKKDRRGWVILYNRQKNNPLVLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUQ7</accession>
    <name>A0A075MUQ7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUQ7"/>
    <dbReference type="STRING" id="1459636.NTE_03373"/>
    <dbReference type="KEGG" id="nev:NTE_03373"/>
    <dbReference type="HOGENOM" id="CLU_1100918_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.170">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="252" mass="27698" checksum="AE7A6D330E9A27C6" modified="2014-10-29" version="1">MKEEHSATVQHSSCYPWNCSKHRPVMAPDGEYVCTKCGIVLSDSGSDLPEDEKIDSSLSSSSSPITDSQVQNPRSNISLFLSHKLGGSEVRNLPGLSTARSLEIANREDDDYTSDKGGKKKDRSKKKKKKGAIPYLSRFSNACSKLGLTHAESEHAWHLFSRLCDELRNPDAHIVINTSEIACYTIAAGVAATTKRVLGERAIANAVMFAFHSKSVRDLYCIRRIVETHSEAVTGISKPALTASAKWIRGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUS6</accession>
    <name>A0A075MUS6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1326 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701400.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUS6"/>
    <dbReference type="STRING" id="1459636.NTE_02870"/>
    <dbReference type="GeneID" id="41598550"/>
    <dbReference type="KEGG" id="nev:NTE_02870"/>
    <dbReference type="eggNOG" id="arCOG11393">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092801_0_0_2"/>
    <dbReference type="OrthoDB" id="6870at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009758">
        <property type="entry name" value="DUF1326"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014581">
        <property type="entry name" value="UCP033303"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07040">
        <property type="entry name" value="DUF1326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033303">
        <property type="entry name" value="UCP033303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="214" mass="23821" checksum="3B9520F9C9B42E96" modified="2014-10-29" version="1">MAQVDWYIEGVEFSNCNCDYACPCQFESRRPTHGYCRGFAAVRIDKGHFGDVVLDGLGAALLYAFPGPIYEGNGECQAVIDERADGKQRDALATVLYGGETNEGATHWWVYRMMSSIVHPPLFKHIEFDMNIERRKARIVIPDVLESTARPIRSPATGAEHRVRINLPNGIEFDLAEIGSGITKTMASIALDLKDTYCHFTVLRQSGKGVVHSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUV3</accession>
    <name>A0A075MUV3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02395</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701018.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUV3"/>
    <dbReference type="GeneID" id="41598105"/>
    <dbReference type="KEGG" id="nev:NTE_02395"/>
    <dbReference type="HOGENOM" id="CLU_084395_0_0_2"/>
    <dbReference type="OrthoDB" id="12176at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13412">
        <property type="entry name" value="HTH_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="223" mass="24910" checksum="6C700F85620D34F2" modified="2014-10-29" version="1">MIVQHEAQIEPSSRFEILENLEKLGVNPEMLDQLSIPALNHLLKTLQKAASSSSVQSRPGRRKSHELSRVVSPADKKILKALLSSTGGVSSLTLSKELDIPLSTVQRRRKRLEANLLEMSYTLKVERFGWRTATLFISTRNGMTAAVGKEILSWKDSVSCVSRTMGENSIDLKADIVFKDNEELVETIGRIKAIEGVEKVSWTEQIRAVGHNNNLISYILDKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUY1</accession>
    <name>A0A075MUY1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701495.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUY1"/>
    <dbReference type="STRING" id="1459636.NTE_02990"/>
    <dbReference type="GeneID" id="41598660"/>
    <dbReference type="KEGG" id="nev:NTE_02990"/>
    <dbReference type="HOGENOM" id="CLU_1237877_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="223" mass="24675" checksum="7CC490A32F18EDFC" modified="2014-10-29" version="1">MTGWLRVDEQAFSGGVEHLVEPEYYNGSCALSLLKVRILETRKLFGATDVILYSIVVNGLPDMKSGTPFWSRQDKFPQVKKGATLSIDPDLGVLLFRGRPQGFLNLYLVAVRDTEETRQFAQLLKENFVAKGIGTIAGSLIQIFSGPTGPVTVPLAREATTQAVEATIDYFAKQKNLAIGVYYASLIREKNYGLGYHPNDYPDSMINCDGHFEVAYEVQKAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MV11</accession>
    <name>A0A075MV11_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-synthesizing GTPase</fullName>
            <ecNumber evidence="2">3.6.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NTE_03035</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.3" evidence="2"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701535.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MV11"/>
    <dbReference type="STRING" id="1459636.NTE_03035"/>
    <dbReference type="GeneID" id="41598704"/>
    <dbReference type="KEGG" id="nev:NTE_03035"/>
    <dbReference type="eggNOG" id="arCOG01563">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027154_0_1_2"/>
    <dbReference type="OrthoDB" id="7798at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01888">
        <property type="entry name" value="eIF2_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03688">
        <property type="entry name" value="eIF2_gamma_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15490">
        <property type="entry name" value="eIF2_gamma_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000065">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000075">
        <property type="entry name" value="Translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050543">
        <property type="entry name" value="eIF2G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015256">
        <property type="entry name" value="eIF2g_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044127">
        <property type="entry name" value="eIF2g_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044128">
        <property type="entry name" value="eIF2g_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022424">
        <property type="entry name" value="TIF2_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03680">
        <property type="entry name" value="eif2g_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003077">
        <property type="entry name" value="PRK04000.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42854">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42854:SF3">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09173">
        <property type="entry name" value="eIF2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 12" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="11">
        <location>
            <begin position="18"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIF85070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="420" mass="45217" checksum="CDA5E6C60ADE5E8E" modified="2014-10-29" version="1">MHWKETLPDWYIKEFGYQPSVNIGTSGHVDHGKTTLVEAITGVWTSAHSEELRRGITIKVGYADAAFYKCTGCEPPQCYGTQPTCEGCGGKAELLRVVSFVDSPGHESLMANMLSGAALMDGAILVMAANEKVPQPQTREHLLALSVLGIQQLVLVQNKADLTTYEEAMDNYKQIKDFVKGSIADKAPIVPVSAQHRLNIDALIEAIETNIKTPKRLKDVPPIMHALRSFDINKPGAPIKQVKGGILGGALVQGEFSVGDEIEIRPGLVDEKKNRYEPITSVISTLGTGAGLVENVKPGGLVAIGTKLDPTYTKSDSLIGSVIGKPGTLPKDVEDVTVETHLFDTAVGTQDMVKVEPIKAKEPLRLNIGTAAAVGTVTSVRDGKMEVKLKKPVCLMPKSRVAISRRIAERWRLIGSGIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MV14</accession>
    <name>A0A075MV14_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SnoaL-like domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MV14"/>
    <dbReference type="KEGG" id="nev:NTE_03040"/>
    <dbReference type="HOGENOM" id="CLU_133108_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="16"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="131" mass="15018" checksum="0EF53714FD7EE0D9" modified="2014-10-29" version="1">MLALGISKEFVQEHIDRWVRAWNSRDLAAVLAMYSDDVEFASPKIKVVMPEKSEGRVKGKKELEKYWSLALQKHHELHFTPVAFAINNDNNECFFEYSSLLNGQKTLVVEKFQFSDSKDGLIVRSSAFYGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MV36</accession>
    <name>A0A075MV36_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">site-specific DNA-methyltransferase (adenine-specific)</fullName>
            <ecNumber evidence="1">2.1.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NTE_02988</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an N(6)-methyl-2'-deoxyadenosine in DNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15197"/>
            <dbReference type="Rhea" id="RHEA-COMP:12418"/>
            <dbReference type="Rhea" id="RHEA-COMP:12419"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90615"/>
            <dbReference type="ChEBI" id="CHEBI:90616"/>
            <dbReference type="EC" id="2.1.1.72"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.1.1.72" evidence="1"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701493.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MV36"/>
    <dbReference type="STRING" id="1459636.NTE_02988"/>
    <dbReference type="REBASE" id="90011">
        <property type="entry name" value="M.NevSR1ORF2988P"/>
    </dbReference>
    <dbReference type="GeneID" id="41598658"/>
    <dbReference type="KEGG" id="nev:NTE_02988"/>
    <dbReference type="eggNOG" id="arCOG02632">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018284_5_0_2"/>
    <dbReference type="OrthoDB" id="45790at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009007">
        <property type="term" value="F:site-specific DNA-methyltransferase (adenine-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022749">
        <property type="entry name" value="D12N6_MeTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051537">
        <property type="entry name" value="DNA_Adenine_Mtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003356">
        <property type="entry name" value="DNA_methylase_A-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038333">
        <property type="entry name" value="T1MK-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42933">
        <property type="entry name" value="SLR6095 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42933:SF3">
        <property type="entry name" value="TYPE I RESTRICTION ENZYME MJAVIII METHYLASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12161">
        <property type="entry name" value="HsdM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02384">
        <property type="entry name" value="N6_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00507">
        <property type="entry name" value="N12N6MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0680">Restriction system</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N6 adenine-specific DNA methyltransferase N-terminal" evidence="8">
        <location>
            <begin position="7"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="DNA methylase adenine-specific" evidence="7">
        <location>
            <begin position="140"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF85023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="512" mass="58505" checksum="DA76302A440A01BE" modified="2014-10-29" version="1">MALSAELKQHIDSLWNKFWAGGITNPLTAIEQMSYLIFMKRLEDLDNLHAKRASQRKDMSYVSVFKGHEDCKWSHWKHYNADSMLKHVRDKVFEFIKTIHNGDDALFAQYMKDAVFVIPKPQLLQEAVAIIDKINITAQNQDVQGDIYEHLLSQLQTSGKNGQFRTPRHIIRLMVTLIDPKIGEKICDPACGTAGFLIGAYEHILAANTSHDIIERDANGVPHNLVGDKIVNKAHWKLLRNETFYGFEVDTTMIRIALMNMILHGVEHPNIRYADSISKSFDQKELYDVVLANPPFTGFVDESTINDNFQIRTAKTELLFLELMHNILHRGGRCAVIVPEGALFANSNAHKNIRKILVENCQVEGIISLPAGVFKPYAGVATSIVLFTKGGRTEQVWFYGTTADGYSLDDKRVPTPYRNDIPDIIKKWSKKQVDNERTWVASYQQIVDNDYSLSANRYKPSVRLETKYEDPSVLLNQILNLENEIQSELRALNDVIEQHQIRSWNAHDERSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MV69</accession>
    <name>A0A075MV69_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701527.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MV69"/>
    <dbReference type="STRING" id="1459636.NTE_03023"/>
    <dbReference type="GeneID" id="41598693"/>
    <dbReference type="KEGG" id="nev:NTE_03023"/>
    <dbReference type="eggNOG" id="arCOG02038">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_714958_0_0_2"/>
    <dbReference type="OrthoDB" id="30795at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051797">
        <property type="entry name" value="TrmB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002831">
        <property type="entry name" value="Tscrpt_reg_TrmB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34293">
        <property type="entry name" value="HTH-TYPE TRANSCRIPTIONAL REGULATOR TRMBL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34293:SF1">
        <property type="entry name" value="HTH-TYPE TRANSCRIPTIONAL REGULATOR TRMBL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01978">
        <property type="entry name" value="TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription regulator TrmB N-terminal" evidence="1">
        <location>
            <begin position="20"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="397" mass="43229" checksum="E41B282F22710CCB" modified="2014-10-29" version="1">MHHQDNISSSPASGDLPASLEEFGLSKYEARAYLTMIGKGSLAASDLAYYANLPRTKVYQTVKKLEKKRLAVVSKQKPLICSAIPPEEAFGEIVNLHERRVKNMRKIVERLQKLSDEGQRPKGSEERRYFILDPDSALSKISSLVANARSSITATLDPWGLRLLAQCRGQLIKAETNGARIRLIVGAQCLGSESLSLLPDGIELKMAGGSASSNLMIIDMTHMVSVDPSNGKAALFASLDAYGAMQAKSFEEAWSKAGEAKHALEAQPALAAKAIELARAVENGLAAHMLEYAMNSEDPAGELVEVMERKYGLKVGTMSAPEILDLVDSALKISCLGWLKHDKSNNIVSLQSKAEGKHVLPWAVVLASYFKRSGNEPKIMQSKQSPQLVHVRLARPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MV84</accession>
    <name>A0A075MV84_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PEFG-CTERM sorting domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MV84"/>
    <dbReference type="KEGG" id="nev:NTE_03136"/>
    <dbReference type="eggNOG" id="arCOG08812">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034350_1_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="464"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="491" mass="53793" checksum="FAE85B21E21E420E" modified="2014-10-29" version="1">MILSKFKYDLYQKTATIIEKRVLALGLAGLVFLPALASQRAFADGLFQENIQGSIAGRNVELFVRINPPVLTTQTQQDAFVQLRLFEGNNQTIRYTTFVMEISKVTGSGEDVLMAPDAFHTESGLLTLKIQPQEGPVQVLATREAILDAWKADLGGTINIKGPVLLDGGLYHFRIDVIGVDSAKELLPPDQVRTFDTYLSVGDVITQDVQYQGKTYPATIISYYDKVKDFKFDANTKTYSWSMPFNWDIKRIKSATSMFVHEEVRIPKSFEGVGDAMTFDASVNGRPITGGMLSLDPFTDENNLILHFLVNKNEILRLEQQVPATAREMEFAFSPASNGSKQQTSGEIATDTGGMLVLLNWTPGQLAANRNATLDLEFYDAFSGNKVTDDVTYDLRTFGPDGSQVHSLAGQVAKDGSDSQTMMFPEDAAYRIEVDVKGVTAAGQQSLDLTRNGIARGTVVIPEFPAGAIAVVAGALGSMIMFHRLARKTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MV96</accession>
    <name>A0A075MV96_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03543</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701942.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MV96"/>
    <dbReference type="GeneID" id="41599161"/>
    <dbReference type="KEGG" id="nev:NTE_03543"/>
    <dbReference type="HOGENOM" id="CLU_2490283_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="86" mass="8713" checksum="9CB6D63C033BBBE0" modified="2014-10-29" version="1">MSATSNKSRVLLLLMIAISLVFFMASFAAAAISGNQQPTPPSSSSSSSPSAPMPGQSATTTTATTTPGEKCMAVRTGEHMLADCSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVP6</accession>
    <name>A0A075MVP6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thiol-disulfide isomerase-like thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_03291</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701745.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVP6"/>
    <dbReference type="STRING" id="1459636.NTE_03291"/>
    <dbReference type="GeneID" id="41598945"/>
    <dbReference type="KEGG" id="nev:NTE_03291"/>
    <dbReference type="eggNOG" id="arCOG03562">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044955_0_0_2"/>
    <dbReference type="OrthoDB" id="9006at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03012">
        <property type="entry name" value="TlpA_like_DipZ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041017">
        <property type="entry name" value="Thioredoxin_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050553">
        <property type="entry name" value="Thioredoxin_ResA/DsbE_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42852:SF13">
        <property type="entry name" value="PROTEIN DIPZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42852">
        <property type="entry name" value="THIOL:DISULFIDE INTERCHANGE PROTEIN DSBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17991">
        <property type="entry name" value="Thioredoxin_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="65"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF85320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="389" mass="42730" checksum="5B4064B28F6E48E7" modified="2014-10-29" version="1">MNRDNASALAVGVAVVVLIAGFGFYFNNPELNKKASAGSAGEFVPVGANNTTTTTTATAKPHIDKSQFKQAPELAGISNYINSQPFKLADLKGKVVLVDFWTYSCINCIRTIPYLNAWYEKYADQGLVIVGVHSPEFDFEKNPQNVQAAVQKFGIKYPVVQDNDHGTWNAYQNRYWPHKYLVDDEGFIRYDHIGEGNYAETEKVIQSLLQERAANLGQNATINTSTTAKPEGAKSVDFGRINTPELYFGYKYARANLGNPEGFDPGKVVTYRLPDDYDAKIEPNVIYLSGDWLNNPDSMELKSHTGRIVLEYSAKSVNIVAGGTGKAYVSEDGHAVGADRGDDVSEQDNAADINGQRLYNLAAHGGYASHTLTIDIVGEGFRIYTFTFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MW06</accession>
    <name>A0A075MW06_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03407</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701847.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MW06"/>
    <dbReference type="GeneID" id="41599052"/>
    <dbReference type="KEGG" id="nev:NTE_03407"/>
    <dbReference type="HOGENOM" id="CLU_2327138_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="98" mass="11349" checksum="2962692FC014721C" modified="2014-10-29" version="1">MTTELVNVGEVRNQFAKLREAYRKVLPKVDPALLNDFLQREAANSDKDEDGIPYTIEVFTKEGLDTQVARQYILEAHLKYLYKHTFSIKRYQSALRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MW99</accession>
    <name>A0A075MW99_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03497</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MW99"/>
    <dbReference type="STRING" id="1459636.NTE_03497"/>
    <dbReference type="KEGG" id="nev:NTE_03497"/>
    <dbReference type="HOGENOM" id="CLU_1727303_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="153" mass="17220" checksum="FE90E64CE2A9AC31" modified="2014-10-29" version="1">MTPRNFAKTNCSLSVVAISALLCDAFLSHKDVFQNTTTTAMAVVYHKADETAAMPTNDNVIVLNPKDSDVRSRLFRSRERTSDGKKKKRQVKFLICDSCFWCASVISMESSPTAGESRIVSCPVCDSKQVEWLPVSTDNYLDDNDEPCEWRHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWB5</accession>
    <name>A0A075MWB5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987220.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWB5"/>
    <dbReference type="STRING" id="1459636.NTE_01511"/>
    <dbReference type="GeneID" id="41597300"/>
    <dbReference type="KEGG" id="nev:NTE_01511"/>
    <dbReference type="eggNOG" id="arCOG05161">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054109_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052729">
        <property type="entry name" value="Acyl/Acetyltrans_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041496">
        <property type="entry name" value="YitH/HolE_GNAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47237">
        <property type="entry name" value="SLL0310 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47237:SF1">
        <property type="entry name" value="SLL0310 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18014">
        <property type="entry name" value="Acetyltransf_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="287" mass="31897" checksum="B78F3FBD371FDD1B" modified="2014-10-29" version="1">MDSSDSFVVRPMKRQELDLALGWAASEGWNPGLHDACAFYDFDSKGYFVGLLSGVPVGCISAVAYDDTFGFLGLYIVKPKHRGRGFGMKLWRHALRRLGDRNIGLDGVVGRQRDYEREGFVLAHRNIRYESAGTIAARTMPRNVVDLRKKYSIDDVAEYEKRLFPAQRARFLDRWLNPPQGAALGYVDDKSGRLAGYGVIRRCVRGYKIGPLFADTHDAARDLLIGLAGHAAGEPVYIDVPEANGMAVDLAKEAGMNKVFETARMYNVSKPDLDILRTYGVTTLELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWB6</accession>
    <name>A0A075MWB6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">Urease</fullName>
            <ecNumber evidence="2 10">3.5.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">NTE_02914</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>urea + 2 H2O + H(+) = hydrogencarbonate + 2 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:20557"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7 10">
            <name>Ni cation</name>
            <dbReference type="ChEBI" id="CHEBI:25516"/>
        </cofactor>
        <text evidence="7 10">Binds 2 nickel ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (urease route): step 1/1.</text>
    </comment>
    <comment type="PTM">
        <text evidence="6">Carbamylation allows a single lysine to coordinate two nickel ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.5" evidence="2 10"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWB6"/>
    <dbReference type="STRING" id="1459636.NTE_02914"/>
    <dbReference type="KEGG" id="nev:NTE_02914"/>
    <dbReference type="eggNOG" id="arCOG00698">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000980_2_0_2"/>
    <dbReference type="UniPathway" id="UPA00258">
        <property type="reaction ID" value="UER00370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009039">
        <property type="term" value="F:urease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00375">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01953">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011612">
        <property type="entry name" value="Urease_alpha_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050112">
        <property type="entry name" value="Urease_alpha_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017950">
        <property type="entry name" value="Urease_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005848">
        <property type="entry name" value="Urease_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017951">
        <property type="entry name" value="Urease_asu_c"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009686">
        <property type="entry name" value="PRK13207.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01792">
        <property type="entry name" value="urease_alph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43440">
        <property type="entry name" value="UREASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43440:SF1">
        <property type="entry name" value="UREASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00449">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01752">
        <property type="entry name" value="UREASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00145">
        <property type="entry name" value="UREASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51368">
        <property type="entry name" value="UREASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7 10" id="KW-0533">Nickel</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Urease" evidence="12">
        <location>
            <begin position="111"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8 9">
        <location>
            <position position="302"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="7">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="7">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="6">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR611612-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR611612-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR611612-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIF84952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="549" mass="58684" checksum="1BB9E9D5AD866ECF" modified="2014-10-29" version="1">MRLADTDLIIEVERDLLFPGDELMFGGGKSVRDGAGQASGITSRQALDLVITNAIVMDPVLGIVKADIGIKNGKIAGIGKAGNPDVMDNVDMIVSSATEVIAGEHTICTPGTIDTHIHFISPQQATEAICAGTTTMIGGGTGPADGTNATTCTPGPWNIHRMLEALDELPLNFGLLGKGNDSREPALIEQIAAGACGLKLHEDWGSTPAAIDAALQVADRTDTQVAIHTDTLNECGFVDDTIEAIAGRTIHTYHTEGAGGGHAPDILKIAGENNILPSSTNPTRPFTANTLEEHLDMMMVCHHLNPSIPEDVAFAESRIRAETIAAEDVLHDIGALSMYSSDSQAMGRVGEVTSRAWQTADKMKKMAGRLKGEKGNNDNLRAKRYLAKLTINPAIAHGISSYVGSLENGKIADIVIWTPQFFGVKPKMVVKGGFIAYSLMGDPSASIPTPEPVYYRPMFGSMGAAKYSTSFTFTSKLAIRNGVRKKLGLKKKLLPVKNCRKIGKRDMLYNDLAPKIDVDPETYEVRVDGKVAASEPAKSLSMSRLYNLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWC5</accession>
    <name>A0A075MWC5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Helicase family protein with metal-binding cysteine cluster</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_02924</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWC5"/>
    <dbReference type="STRING" id="1459636.NTE_02924"/>
    <dbReference type="KEGG" id="nev:NTE_02924"/>
    <dbReference type="eggNOG" id="arCOG00555">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000809_3_2_2"/>
    <dbReference type="OrthoDB" id="36796at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018973">
        <property type="entry name" value="MZB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47957">
        <property type="entry name" value="ATP-DEPENDENT HELICASE HRQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47957:SF3">
        <property type="entry name" value="ATP-DEPENDENT HELICASE HRQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09369">
        <property type="entry name" value="MZB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="3">
        <location>
            <begin position="178"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="393"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF84962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="881" mass="97509" checksum="A243E78174ABE568" modified="2014-10-29" version="1">MRDVIIVYSGRQFSQEQQDAGVANNSSYRCPKCSSPHSVGADRIFDGRLMFRCARCKICAIVQSSTSTDESYLEFLDKCEDGGGAATTDDLRLLMEQEKIIRPKKEIDAFLAGLEGKDPLLEEVLRSDRDYVVDFRSLEEPPPEYGNDVNSMPVDEGIISVLKAKGIEKLYKFQEEAIKKILQGNDVVITAPTASGKTEAFCIPILQKIAEEVSRFGSLRAGERGKIMAIFVYPTKALGRDQMPKITELAEPLGVRAAVLDGDTPDTERARVLESPPDIIVTNFDVIHYHMMHRTKFSRALRTAKFLVVDEAHVYTGVFGANVHHIIARLERLASSKMQIAAASATLPNAADFCKALFGREMQAIKGRGRRGRVNLAIIFPSLRSHRSLALDILKEAAAKGKHRTIAFSNSHLGSELLAFYAARQGVSIRVHRAGLTASARAGVEEMFKSGKLSAISATPTLELGIDIGDVDAIVSNIVPVNRLVQRIGRAARRGQEGYAFLALGNDPISQYYKSHPDDYLSDQEFAYTDPENPFVKEFQILAMACDRPVSMAESKGAWDTVQKLVSRGLLSLEKERFVPDFKKAMAVLNSYSIRGIGSRVDIKLAGKIIGDRSLPQALEELHQDAIYFLAGRRYRVKALHFERDRQPYAELEAIPYDYPYYTKALTDEWPSILEVHERKKVFGIEVAYCSLKIQKRVLGYANVEIGQEAAQGKTKVMFDQPLEYEFFTKGFVFRAPRPEETMSKADDEEYVEMSAFHASEHVIIEGSAMITGGASQDLGGISLGSSGLIFVYDGSIGGNGASKVLYDRLDKALGRALRILSECPCTSESGCPRCTYSYRCGNNNEYLHKAAAIEVMNRAVEGEATKIGDDEEIQGDRALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWQ7</accession>
    <name>A0A075MWQ7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_01638</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in DNA damage repair.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Nre family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700423.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWQ7"/>
    <dbReference type="STRING" id="1459636.NTE_01638"/>
    <dbReference type="GeneID" id="41597414"/>
    <dbReference type="KEGG" id="nev:NTE_01638"/>
    <dbReference type="eggNOG" id="arCOG04269">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039703_0_0_2"/>
    <dbReference type="OrthoDB" id="6609at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02096">
        <property type="entry name" value="Nre"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033167">
        <property type="entry name" value="Nre"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006979">
        <property type="entry name" value="Nre_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006978">
        <property type="entry name" value="Nre_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38136">
        <property type="entry name" value="DNA REPAIR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38136:SF2">
        <property type="entry name" value="DNA REPAIR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04895">
        <property type="entry name" value="Nre_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04894">
        <property type="entry name" value="Nre_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Archaeal Nre N-terminal" evidence="2">
        <location>
            <begin position="24"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Archaeal Nre C-terminal" evidence="3">
        <location>
            <begin position="286"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF83699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="395" mass="44359" checksum="325FB51EAE3F45BB" modified="2014-10-29" version="1">MSLSPAEIKRRLEQNWIQFLTANSARLSMDTLDGASPPSMFVGRYGYPKVRIGPMIPPVHGDTTVYDKTEMWVGKTLEEIANLRLSLVRGVMSVNVGDTSGRYIENLQELAMSERPAESEATFEKKPLADMELDRELRLNTEAAPFGPAAPIKTFKASSLSADQKIESAFYDGDLRAKDAVMELYKKGIETSRIHRVLSVGMLGLKKNRKLVPTRWSITATDDIISANVVRQNEANESIDLFEVRQYSHLGNYYSVILIPDSIWSFEMIESWYAGDGKMATGADYEDARGLDHYPSIAGAYFAARLAVAEHLSKRRRKAAALVLREIHPEYVMPVGVWQIREGVREALKTPAKAFEGFDGALAFACSTMSQSRAEILRHSQLYRNFRSQTRITDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWS9</accession>
    <name>A0A075MWS9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate reductase</fullName>
            <ecNumber evidence="9">1.1.1.302</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NTE_03545</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NAD(+) = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27274"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58890"/>
            <dbReference type="ChEBI" id="CHEBI:59545"/>
            <dbReference type="EC" id="1.1.1.302"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NADP(+) = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27278"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58890"/>
            <dbReference type="ChEBI" id="CHEBI:59545"/>
            <dbReference type="EC" id="1.1.1.302"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; riboflavin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HTP reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.302" evidence="9"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701944.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWS9"/>
    <dbReference type="STRING" id="1459636.NTE_03545"/>
    <dbReference type="GeneID" id="41599163"/>
    <dbReference type="KEGG" id="nev:NTE_03545"/>
    <dbReference type="eggNOG" id="arCOG01484">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036590_4_1_2"/>
    <dbReference type="OrthoDB" id="10178at2157"/>
    <dbReference type="UniPathway" id="UPA00275"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="entry name" value="Dihydrofolate Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006401">
        <property type="entry name" value="Rib_reduct_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011549">
        <property type="entry name" value="RibD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050765">
        <property type="entry name" value="Riboflavin_Biosynth_HTPR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01508">
        <property type="entry name" value="rib_reduct_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00227">
        <property type="entry name" value="ribD_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38011:SF7">
        <property type="entry name" value="2,5-DIAMINO-6-RIBOSYLAMINO-4(3H)-PYRIMIDINONE 5'-PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38011">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_8G06820)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="Dihydrofolate reductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0686">Riboflavin biosynthesis</keyword>
    <feature type="domain" description="Bacterial bifunctional deaminase-reductase C-terminal" evidence="10">
        <location>
            <begin position="2"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="NCBIfam" id="TIGR01508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIF85573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="217" mass="23030" checksum="1CE9702C3A443957" modified="2014-10-29" version="1">MKITINAAMTIDGKIATASGDSTISSKEDLKRVHRLRAASDAVVVGISTVLADNPQLTVRLVRGKNPVRVVVDSKCRIPGGSQILRTAGRVRTIVAASAQASAADVERIRQAGAEVIIAGNEAVDIKALFSTFKKKMGFKKILVEGGGELNWSVLNLGLADELIVTVAPRVAGGRLATTLVEGDGYDTISQGPKFRLAHVQKTRAGELVLFYRVGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MX10</accession>
    <name>A0A075MX10_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rps15</name>
        <name evidence="7" type="ORF">NTE_01753</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MX10"/>
    <dbReference type="STRING" id="1459636.NTE_01753"/>
    <dbReference type="KEGG" id="nev:NTE_01753"/>
    <dbReference type="eggNOG" id="arCOG04185">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090139_2_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.10:FF:000003">
        <property type="entry name" value="40S ribosomal protein S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01343_A">
        <property type="entry name" value="Ribosomal_uS15_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_uS15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023029">
        <property type="entry name" value="Ribosomal_uS15_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012606">
        <property type="entry name" value="Ribosomal_uS15_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="uS15_NS1_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006331">
        <property type="entry name" value="PRK08561.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11885">
        <property type="entry name" value="RIBOSOMAL PROTEIN S15P/S13E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11885:SF6">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08069">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01386">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="S15/NS1 RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00362">
        <property type="entry name" value="RIBOSOMAL_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS15 N-terminal" evidence="6">
        <location>
            <begin position="9"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF83814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="157" mass="17356" checksum="E1C2FEE062CAE9EB" modified="2014-10-29" version="1">MAEAVKSYMARIHVHTHGKSHSIRPTSKAAPSWLTTTPDQVSSLVVKMAKDGVTPSVIGIKLRDEHGVPLAKSVTGKTVTQVLADNNIKSDMPEDLERLVRKALGLQKHLRAHNSDHRNVRSLELVEAKIHRLAKYYKGIGKLPATWKYAAVIAQLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MXC0</accession>
    <name>A0A075MXC0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03238</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701699.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MXC0"/>
    <dbReference type="STRING" id="1459636.NTE_03238"/>
    <dbReference type="GeneID" id="41598893"/>
    <dbReference type="KEGG" id="nev:NTE_03238"/>
    <dbReference type="HOGENOM" id="CLU_1648236_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="160" mass="18333" checksum="C5FA21E6F693406A" modified="2014-10-29" version="1">MIDNDEEDENNGRDFFLPIGEELEKIRASSNRNFVKMLQLIELGIKNWQTASAILAIAYDDSLTKKQKEQIAKSYEEKFGEFPDIEPFLELGRNKMNHSFEESFFLPYENHVKHHELDSKLVNPDPHCIICQLVEKTGSSTLKNNDNDDGGRATYGHDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MXE0</accession>
    <name>A0A075MXE0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phasin protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701713.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MXE0"/>
    <dbReference type="STRING" id="1459636.NTE_03253"/>
    <dbReference type="GeneID" id="41598908"/>
    <dbReference type="KEGG" id="nev:NTE_03253"/>
    <dbReference type="HOGENOM" id="CLU_113181_0_0_2"/>
    <dbReference type="OrthoDB" id="10637at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="203" mass="23271" checksum="25DCF8457A875DAA" modified="2014-10-29" version="1">MASRKDDKEESEKRAAEGGGGSRAGSNPNPQQQELQQQQEAVARSIDETKQNIREAIEEARKEIPKYNQVVNDYQNQTIDATRDIAESYLDSQRHAINTMQSGWMQYMQQQQQQSWWGMPMSPQAMADMYTRMAGSFADATIATTRMANNMMFANIEAARATMNHARDNTREMVRIATDFTETFGQASREARSRTEDERRRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MXK0</accession>
    <name>A0A075MXK0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01971</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700683.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MXK0"/>
    <dbReference type="STRING" id="1459636.NTE_01971"/>
    <dbReference type="GeneID" id="41597719"/>
    <dbReference type="KEGG" id="nev:NTE_01971"/>
    <dbReference type="HOGENOM" id="CLU_1096677_0_0_2"/>
    <dbReference type="OrthoDB" id="10010at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="253" mass="27818" checksum="6397039641E40333" modified="2014-10-29" version="1">MALDPNVLNPYVLLDPAIAPIASAVFTAASIALSLAISWYFFRSYRFAGFGYLLGLPAGFVFLAASFAFEHAGFMYSADPLLYPAFFWLQLALQSEALALIAISYFFKNAGEQEGHRLGIKDAGMILLPLVMVALPFLLPTSEIASKPYFNYAKLADFSLYMRVFNMAVLAYIFTNAVSSLAKSGMVKMLYVPAAFALLWLEQYSLVMAYFDNSVFAFAGSIIARVGGLALFAYVMHSATSKRRIEVEARKAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MYA4</accession>
    <name>A0A075MYA4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DhnA-type fructose-1,6-bisphosphate aldolase-like enzyme</fullName>
            <ecNumber evidence="2">4.1.2.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeoC/FbaB aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.-" evidence="2"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700847.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MYA4"/>
    <dbReference type="STRING" id="1459636.NTE_02180"/>
    <dbReference type="GeneID" id="41597904"/>
    <dbReference type="KEGG" id="nev:NTE_02180"/>
    <dbReference type="eggNOG" id="arCOG04044">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057069_1_0_2"/>
    <dbReference type="OrthoDB" id="6329at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00958">
        <property type="entry name" value="DhnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050456">
        <property type="entry name" value="DeoC/FbaB_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041720">
        <property type="entry name" value="FbaB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006081">
        <property type="entry name" value="PRK08227.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47916:SF1">
        <property type="entry name" value="3-HYDROXY-5-PHOSPHONOOXYPENTANE-2,4-DIONE THIOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47916">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATE ALDOLASE CLASS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038992">
        <property type="entry name" value="Aldolase_Ia"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="281" mass="30628" checksum="D48D301AC6B8EDEA" modified="2014-10-29" version="1">MDWGMKNRLSKIIRPQDGRCLMLAVDHGYFLGPTERLENAAETIAPLLPYADSLMLTRGILRNCVPAERDIPIVLRVSGGTSIIGEDLSKETITTSIEEAIKLNVSCLALSIFVGSKYEHQTLASLGKLVDEGEKYGIPVLAVTAVGKEMGRDARYLGLACRVAAELGAHVVKTYYCDNFEKVVEACPVPLVVAGGKKLPEMDALKLAHDSVTHGASGVDMGRNIWQSDYPVAMVKAVKAIVHGKADVKEAYDVFLREREKSKAKEPQKIVKAISRSADFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MYF4</accession>
    <name>A0A075MYF4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Family 3 adenylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700901.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MYF4"/>
    <dbReference type="STRING" id="1459636.NTE_02245"/>
    <dbReference type="GeneID" id="41597964"/>
    <dbReference type="KEGG" id="nev:NTE_02245"/>
    <dbReference type="eggNOG" id="arCOG07810">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057456_0_0_2"/>
    <dbReference type="OrthoDB" id="9201at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009190">
        <property type="term" value="P:cyclic nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050697">
        <property type="entry name" value="Adenylyl/Guanylyl_Cyclase_3/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43081:SF1">
        <property type="entry name" value="ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43081">
        <property type="entry name" value="ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="1">
        <location>
            <begin position="140"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="343" mass="38220" checksum="14E777F24A250448" modified="2014-10-29" version="1">MEGYGSRRINKNENAIICSTKVHESRLRATTKQAAMNLYHAGLFPDTIAMQLDISREEVDSIIKDAIAEDEKKRKSIKQASDTSSIGMFYLDAVVNIENIIKSAQLAMWKSLKGEMEFNISNEDTQSVLEKMAESKATFVILYIDIVGSTKLSMTLPVDRLAAIIRGFTHEMSLVVSAYGGHVLKYLGDAILAFFVVPDKSNPYMPCTNAMHCARSMVRAVKEGFNVILNQEGYPELEVRIGIDVGENVVVQYGWDVQSLVIDDRQINTKKAHQDILGYTISMASKITGLAQPNQIVIGQYVYDVLDERQKGLFELLPLPPEVWSYVGSKTGNLYSLYASALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MYY4</accession>
    <name>A0A075MYY4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02419</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_264357906.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MYY4"/>
    <dbReference type="STRING" id="1459636.NTE_02419"/>
    <dbReference type="GeneID" id="75933629"/>
    <dbReference type="KEGG" id="nev:NTE_02419"/>
    <dbReference type="HOGENOM" id="CLU_3282670_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="40" mass="4333" checksum="3C54F078C8CAC8F7" modified="2014-10-29" version="1">MFEQILWVVLGFAPTLAALQAADKMIANSKNSSKPLEVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N003</accession>
    <name>A0A075N003_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02783</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701333.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N003"/>
    <dbReference type="STRING" id="1459636.NTE_02783"/>
    <dbReference type="GeneID" id="41598472"/>
    <dbReference type="KEGG" id="nev:NTE_02783"/>
    <dbReference type="HOGENOM" id="CLU_2534800_0_0_2"/>
    <dbReference type="OrthoDB" id="10928at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="84" mass="9610" checksum="8ACFFD331B54F3F2" modified="2014-10-29" version="1">MPATNSSKRKKRSRQGEDDELVPPRKITGKELTELEELSARLTTLVEMLDEKGIINKKEYDRTVAMRLHEISKAGAIEELDEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N043</accession>
    <name>A0A075N043_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02829</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N043"/>
    <dbReference type="STRING" id="1459636.NTE_02829"/>
    <dbReference type="KEGG" id="nev:NTE_02829"/>
    <dbReference type="HOGENOM" id="CLU_2783848_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="68" mass="7895" checksum="54D15BA5F327DDDD" modified="2014-10-29" version="1">MLEKSTLRKGSPITLKDKTVARLLAYIRFTYEGHFSLRQSTQIQQNEGSYLFQFLSGSVNQEYMSSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N192</accession>
    <name>A0A075N192_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N192"/>
    <dbReference type="KEGG" id="nev:NTE_03200"/>
    <dbReference type="HOGENOM" id="CLU_2695535_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="73" mass="8681" checksum="1E896C256D11B5D7" modified="2014-10-29" version="1">MNNDEIRYKILLVLYNKFYNGQARRHIVTDNAINEAGLLNTDTRIYPNIDYLMKNGYLREFVLLVFPTQLISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N1A9</accession>
    <name>A0A075N1A9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GMP synthase [glutamine-hydrolyzing]</fullName>
            <ecNumber evidence="10">6.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">GMP synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Glutamine amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">guaA</name>
        <name evidence="13" type="ORF">NTE_03220</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Catalyzes the synthesis of GMP from XMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>XMP + L-glutamine + ATP + H2O = GMP + L-glutamate + AMP + diphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:11680"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.2" evidence="10"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N1A9"/>
    <dbReference type="STRING" id="1459636.NTE_03220"/>
    <dbReference type="KEGG" id="nev:NTE_03220"/>
    <dbReference type="eggNOG" id="arCOG00085">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014340_0_5_2"/>
    <dbReference type="UniPathway" id="UPA00189">
        <property type="reaction ID" value="UER00296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003921">
        <property type="term" value="F:GMP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01742">
        <property type="entry name" value="GATase1_GMP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01997">
        <property type="entry name" value="GMP_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000002">
        <property type="entry name" value="GMP synthase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000001">
        <property type="entry name" value="GMP synthase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000001">
        <property type="entry name" value="GMP synthase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00344">
        <property type="entry name" value="GMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001674">
        <property type="entry name" value="GMP_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004739">
        <property type="entry name" value="GMP_synth_GATase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022955">
        <property type="entry name" value="GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025777">
        <property type="entry name" value="GMPS_ATP_PPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00884">
        <property type="entry name" value="guaA_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00888">
        <property type="entry name" value="guaA_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000848">
        <property type="entry name" value="PRK00074.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11922:SF2">
        <property type="entry name" value="GMP SYNTHASE [GLUTAMINE-HYDROLYZING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11922">
        <property type="entry name" value="GMP SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00958">
        <property type="entry name" value="GMP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00099">
        <property type="entry name" value="CPSGATASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51553">
        <property type="entry name" value="GMPS_ATP_PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5 10 11" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="3 10 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10 11" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMPS ATP-PPase" evidence="12">
        <location>
            <begin position="201"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="228"/>
            <end position="234"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIF85249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="517" mass="57579" checksum="7E127950667D99E0" modified="2014-10-29" version="1">MEDNNNKMDKIVVLDFGSQYSHLICRRIREANVYCELVPYNTPAKALKEMDPKGIIFSGGPASVYAKGAPKPDRQIFAMGKPILGICYGHQVLVDNFGGKVKKAASREYGRAGLKIDDDSDLFKNLDTSINCWMSHGDAAEKVPEGFKVIGHTENSQSAAIGSRERKMYGIQFHPEVVHTERGMQILKNFAQEISGAKPEWDMQSFIDTTVKEIREQVGEKRVLAAVSGGIDSTTVAALMHRAIGKQLSCVFINHGLLRQDEEKEVVRLFKEHLGIDLIYVNAEKRFLSRLKGVSDPEKKRKIIGDQFAKEFVAVAKKHGPFQWLAQGTLYPDVIESGVSKGPAAVIKTHHNVGGLPKWLKLQVIEPLRFLYKDEVRKVAKLLEVPDELLKRHPFPGPGLAVRIIGAITPEKTRIAKHASKLVEDELKAAGYYDKVWQAYAAVGDDRAVGVLGDERVYGHIVMVRVVESIDAMTADWTRLPYDVIERISNRITNEVEGATWVTYAVSSKPPATIEPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ML75</accession>
    <name>A0A075ML75_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Family 3 adenylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00092</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ML75"/>
    <dbReference type="STRING" id="1459636.NTE_00092"/>
    <dbReference type="KEGG" id="nev:NTE_00092"/>
    <dbReference type="eggNOG" id="arCOG07810">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057456_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009190">
        <property type="term" value="P:cyclic nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050697">
        <property type="entry name" value="Adenylyl/Guanylyl_Cyclase_3/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43081:SF1">
        <property type="entry name" value="ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43081">
        <property type="entry name" value="ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="1">
        <location>
            <begin position="133"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="330" mass="36756" checksum="5491E5F46DFF928D" modified="2014-10-29" version="1">MSLIADLRCKCGINMSDPATPDSQRQIIINLYNSGIEPDIIALQLDVDREQVDRTIAEFAAEEERKHDSANATSGAPSLSSFELGPVVDTEQAVRLAQERVWRALRFEPQFNLSTEETNNILEKFAKSKVGFVILYVDVVGSTKLSMTIPADRLATIVQAFTQEMSILISAYGGYVLKYVGDAILAFFLADWNNLRVPCANAVSCAQAMIKVMRQGVNPILNQYDYPELNVRVGIDVGDNVVVQYGWDTMTLEDGRQVRRPHLDILGYTISVTAKMTGIAKPDQIMIGQFVYEALCDEAKEAFAPVQIGPEKWDYVSDYTGKIYKLYGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLE5</accession>
    <name>A0A075MLE5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00164</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699277.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLE5"/>
    <dbReference type="STRING" id="1459636.NTE_00164"/>
    <dbReference type="GeneID" id="41596099"/>
    <dbReference type="KEGG" id="nev:NTE_00164"/>
    <dbReference type="HOGENOM" id="CLU_1754602_0_0_2"/>
    <dbReference type="OrthoDB" id="385752at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="148" mass="16084" checksum="F111090198D89D75" modified="2014-10-29" version="1">MALGEKLFEEIGQAAGFRITKTHPVEGTTMEVSFTSDLKGVGKFPSGKNMGSGVVIQYPHGVVDGSYQGILKTTDGEQVFWWAHEKGKVVAAERNGGGSSGDKIKSLIIVSAFTNSQKLSWINNLIMALEAERDLVSHHSKTVAYEWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLQ5</accession>
    <name>A0A075MLQ5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00344</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLQ5"/>
    <dbReference type="KEGG" id="nev:NTE_00344"/>
    <dbReference type="HOGENOM" id="CLU_2327133_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="98" mass="11395" checksum="60BBC9B0758F5E07" modified="2014-10-29" version="1">MWKVPFSTTFLEAGTLDEIIKRMRIERQSSLTPGDLELLRFILAKEIANIEETIKNNPDDIEENKERQMYVTRIDVIRQKIVTRLVTSSWSWTGSPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MM40</accession>
    <name>A0A075MM40_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF2127 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00236</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MM40"/>
    <dbReference type="KEGG" id="nev:NTE_00236"/>
    <dbReference type="eggNOG" id="arCOG09752">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119855_0_0_2"/>
    <dbReference type="OrthoDB" id="12278at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="152" mass="15271" checksum="66352910734BC842" modified="2014-10-29" version="1">MRTTTGTGTRPLGVSIIAILNVISGIIMLIGGTGLAAVGSALPTMTTVDPNAGGQMALVGLLGGGAAAVGAVLIVLGIVSFIVAWGLFKGKGWAWTVTIILSAISVIMGIVSLVGGNFGAIVNIIIAGVVIYYLYRPHVKAYFGKTATTSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MM65</accession>
    <name>A0A075MM65_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00128</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MM65"/>
    <dbReference type="STRING" id="1459636.NTE_00128"/>
    <dbReference type="KEGG" id="nev:NTE_00128"/>
    <dbReference type="HOGENOM" id="CLU_518392_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="525" mass="57809" checksum="8DEBCFDC73197818" modified="2014-10-29" version="1">MIKNFVSLAAQVIKYHETDVKCISLLDDSELLRKELISAIRNTRAATTDTIDRFYERNSNIFSSVTGLQSAGGNTFLTDAKASLDRMLTDVEANSSQQQEKYNENIKSTTNANRIAAINAVQGWLSDENRNFPGSVLANLSIELEAHIDPATHNNNYKVIRTASTSVSTPKSAVAVTNKDEEGEKEAGAKAAAITSTMPFTYVFEFESAGIEFWNYRKKVVDLGIKELMLPVGMKLPMSEKVKNTFRLGSKKEESAKEPHFTKADDFYMSSVVLRDDKTLEVQLASDISAGHAREGKGELFTITFDMVSLPDSSAHSGNNNISLPSSSTNSATFSTTRPTIHYTDNRDRGEEGQATAMVETDLLRIKEIEQATDLRKLTTFGTAVLTKMQILRDPKILALKGKLKLLAVEEKEAIAMSRRNVSGGAAAEPTGSGFTATAATAIMSPLVFIEFRLLFDLLEALARSFGPAIGKLREKTPVKEELILRQELEGGQRKEFAVRLADLRLQLEETTHGKSISRTLFGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MM69</accession>
    <name>A0A075MM69_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative nucleic acid-binding protein, contains PIN domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NTE_00271</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PINc/VapC protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699353.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MM69"/>
    <dbReference type="STRING" id="1459636.NTE_00271"/>
    <dbReference type="GeneID" id="41596180"/>
    <dbReference type="KEGG" id="nev:NTE_00271"/>
    <dbReference type="eggNOG" id="arCOG02219">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118482_3_2_2"/>
    <dbReference type="OrthoDB" id="11240at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09881">
        <property type="entry name" value="PIN_VapC4-5_FitB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050556">
        <property type="entry name" value="Type_II_TA_system_RNase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33653">
        <property type="entry name" value="RIBONUCLEASE VAPC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33653:SF1">
        <property type="entry name" value="RIBONUCLEASE VAPC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIN" evidence="7">
        <location>
            <begin position="2"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF82353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="132" mass="14612" checksum="55096C1D4C2856B9" modified="2014-10-29" version="1">MVCFDTDFLIAFLQKDPDAIKKLEDIQVGDGDTAAITTTVNAAELWKGAYRSKDGQKEAAKVKRLLDLLELITLDRESARMVGELDATTIKSKPIGETDLLIASIALSNKQPLVTKNRKHFERVPGLQVEGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMB1</accession>
    <name>A0A075MMB1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sugar phosphate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NTE_00183</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699291.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMB1"/>
    <dbReference type="STRING" id="1459636.NTE_00183"/>
    <dbReference type="GeneID" id="41596113"/>
    <dbReference type="KEGG" id="nev:NTE_00183"/>
    <dbReference type="eggNOG" id="arCOG00130">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG00134">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_629495_0_0_2"/>
    <dbReference type="OrthoDB" id="200998at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF399">
        <property type="entry name" value="FI19708P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="423"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="451"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="21"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="380"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="404"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF82265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="475" mass="50175" checksum="BB9C183CC0618A52" modified="2014-10-29" version="1">MSRDSSTSNNHRFPYSADVSASVSIIIARVFYAVNWFNVAAIFPLLVLDFGQHDIGLLGSISAAFFIGVGMFQVPAGIFAARYSPRSMAIFGIGLSSSVALLYGFTSEASQLIWLRFIVGAGMALFFSSGVVLIAKHAGGTKKSSGFSIGLLNSAHSAGGIIGLFGWIVIAQMVGWRSSLVLSGAIGIATALPMIIAIPSSAHRRPISKRPPPPAADAAVNNNYSESRDIISPSPPEAQAGGNRWPDISEIWGTLSNPSLIALGLVLTGIQASWALLLTFTIVYLQSLNIQLESAGVIASMALISAIVSAPLIGGYYDKKVKDSRKILLACGVGISAALAAMSIQILSVIIIAVIALGFFSGGAFTFAYAKARTIRTTARGRGQDERNNSVSLQHEERRGEDTSSYSSADKNKSSYNSSALNVAWINGLSLIGILWMPLVFSLAVKSGGGYSNAWLLSAILAALFMFIPLQKVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMP2</accession>
    <name>A0A075MMP2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00456</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699489.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMP2"/>
    <dbReference type="STRING" id="1459636.NTE_00456"/>
    <dbReference type="GeneID" id="41596332"/>
    <dbReference type="KEGG" id="nev:NTE_00456"/>
    <dbReference type="eggNOG" id="arCOG03142">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121770_0_0_2"/>
    <dbReference type="OrthoDB" id="17710at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="219" mass="24267" checksum="7EF2B754ABC2AC5E" modified="2014-10-29" version="1">MQQQYKVAVATLRGRPYYEITHALKQMGIRYDSMSPEEAADSDCKVVITTRDEAGSISSAVTGRKAMMVMLDTELVRYPAIAKAKMLRSIAGPQVDDQLTIGIDPGNRIGISVMYLHEEIASIVESSPASAVEEISAVLEGVISRRKVVKIGDGNIRMALSMAWAVKKKFHNDVEVEIVDEHGTSRPQTNEVNRRGIRDRLSARTIAFRSGKPYYLSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMU6</accession>
    <name>A0A075MMU6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00517</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699542.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMU6"/>
    <dbReference type="GeneID" id="41596393"/>
    <dbReference type="KEGG" id="nev:NTE_00517"/>
    <dbReference type="HOGENOM" id="CLU_201544_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="71" mass="8222" checksum="DC2076F2621A0DF7" modified="2014-10-29" version="1">MQEQEAAEVTDLRSLGINPKRKKELNDKKELEELADNIKQSMFQDYKTACSRKGRKYEKEAKSTLIASVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MN70</accession>
    <name>A0A075MN70_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NTE_00905</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699839.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MN70"/>
    <dbReference type="GeneID" id="41596743"/>
    <dbReference type="KEGG" id="nev:NTE_00905"/>
    <dbReference type="eggNOG" id="arCOG01096">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038957_2_0_2"/>
    <dbReference type="OrthoDB" id="11824at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008217">
        <property type="entry name" value="Ccc1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31851">
        <property type="entry name" value="FE(2+)/MN(2+) TRANSPORTER PCL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01988">
        <property type="entry name" value="VIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF82981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="228" mass="24810" checksum="6ED86A860AE2E86F" modified="2014-10-29" version="1">MRWSLEDFVYGATDGAVTTFAVVAGVVGASLSPAIVLILGFANLFADGFSMAVGNYLATKSQKEAIERARQREEWEIDHLADQEKQEIRDIYAKKGFKDELLEEIVRIITSRRKVWLDTMMKEELGLIEDRRRPIDTAVTTFAAFNAIGVIPLLPFVAIYAAGTITISQEAFVYSSVFTAIAFFIIGAVKGRILGKSLARSGLGTLALGGIAAAVAFLVGYILNHLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MN85</accession>
    <name>A0A075MN85_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CARDB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_00930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699861.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MN85"/>
    <dbReference type="STRING" id="1459636.NTE_00930"/>
    <dbReference type="GeneID" id="41596765"/>
    <dbReference type="KEGG" id="nev:NTE_00930"/>
    <dbReference type="eggNOG" id="arCOG02080">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_459777_0_0_2"/>
    <dbReference type="OrthoDB" id="11801at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35902:SF3">
        <property type="entry name" value="NPCBM-ASSOCIATED, NEW3 DOMAIN OF ALPHA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35902">
        <property type="entry name" value="S-LAYER DOMAIN-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="633"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="482"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="661"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="495"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="541"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="690"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF83006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="701" mass="73348" checksum="7811EA737FAF1242" modified="2014-10-29" version="1">MMSSYTGKRNTGAQILSILLIGTLLFSLSSALKNASAEGDLPQPSERQIIDGSVSGPAFLNAYWTDRSASTSTADVRKEVGPGDGASTLAVVMVNRGFSAITGITGSLTLPQGFSSNGRASSSDTAVATVDSVVDAGQTFILYFDLDVSDSTRVGTYNTALKVEYQRLYETGSPRTSEDTIPFRLTGKVILDPVAVTHNLVPGVSNNVDIAIRNTGSAPATGVIVSMTGISINGGSTSTIESSSGSTIRPQITNFGTNTFTIGTIPARSNATFTTALFPNISAGGNTAGIQLQITYNDATGSAKTLTPAVGVIVLQNAPSIIAVRASSGENQTDNRIVAGKADNFVLEIANKGTSLITNAVVTMQSSSTSLNILGDSKWAVDQIEPGSQAKLETQVFASTSLIGNPATFDVTIDYILDGSPKTEKYVLGTYVDGEISLRIYDLSINYVGATPTLVGNILNEGNTAAFFTTIELVQTPGQNQLATRGNFTGAGEFNPQQQPQQNNNSPGGNGQSNPLGSLFPQQQNNAANNNNGNGNGGGQFRRNNNNTAFAPPAPQYLGDLTANSPLPFSIPLNIQRAEPGTLYPVTVKITYKDNLRNSHEFVTSGNAVVASQQQVANITLGGRTQNPVGGPLFMLIIVGAAIGAATAAFFVIRKKRAKNKKKLNTPGNGPDKRKNIEDILENPAATDVAKTKDDPSTTTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNB6</accession>
    <name>A0A075MNB6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00966</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699887.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNB6"/>
    <dbReference type="GeneID" id="41596796"/>
    <dbReference type="KEGG" id="nev:NTE_00966"/>
    <dbReference type="eggNOG" id="arCOG08662">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_182705_1_0_2"/>
    <dbReference type="OrthoDB" id="5605at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="82" mass="9410" checksum="72860840D69BD33B" modified="2014-10-29" version="1">MTCKGICIRHKAQKPVGSGRYASGQKRCQICEIFIKWDGLWCPCCGYRLRTKPRNLKYKAKLRAKAAKMVDEAPPVLTVRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNG7</accession>
    <name>A0A075MNG7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RecB family exonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01022</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNG7"/>
    <dbReference type="STRING" id="1459636.NTE_01022"/>
    <dbReference type="KEGG" id="nev:NTE_01022"/>
    <dbReference type="eggNOG" id="arCOG00790">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1280849_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="226" mass="25964" checksum="1B89859221C9A450" modified="2014-10-29" version="1">MLKRHSNSDMLGDRNLRGMIEKALDRLNDDLNIKIDRKNPDRIHALEAALCTRLSYYERKDPIPDDNASKVSILLSHGIRNALSNIQGEYKVDSLTLDVNADMMIGDEFVVRFEIVPELPPMPHPRHLLYLNTCLFALGKDEGILIYMTADGKTAEYSVTKNNRMFEEIVRRARVLSTLLKDNKVPIVEPSDLCLKCKYYSRCYSREKARESTDMLQEIFGKLSPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNI6</accession>
    <name>A0A075MNI6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative dehydrogenase</fullName>
            <ecNumber evidence="7">1.1.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NTE_00683</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the L2HGDH family.</text>
    </comment>
    <dbReference type="EC" id="1.1.3.-" evidence="7"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699668.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNI6"/>
    <dbReference type="STRING" id="1459636.NTE_00683"/>
    <dbReference type="GeneID" id="41596540"/>
    <dbReference type="KEGG" id="nev:NTE_00683"/>
    <dbReference type="eggNOG" id="arCOG00754">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024775_0_1_2"/>
    <dbReference type="OrthoDB" id="2001at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047545">
        <property type="term" value="F:(S)-2-hydroxyglutarate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43104">
        <property type="entry name" value="L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43104:SF2">
        <property type="entry name" value="L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="6">
        <location>
            <begin position="5"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF82763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="436" mass="47684" checksum="EEFAC5DB51FC244D" modified="2014-10-29" version="1">MHYSVAVIGGGILGTSIAYFLSGQARDPGSVALVEQELDIARHTSSRNTGKVHAPFLYDPAKKKLFAKAASLGFEMWEKFAQARGLPFKRDGVLEVATDERGMDRLHKYMSWGEANGLAKDDLMLLDKAAVKKMEPSVQCEAAIYCGKDGSVDYGSFSRALLQDLRSFGCAVLLGHCVTRIENNSKAGAYVISTRQGRKIEAEFIVNAAGGNAVDIAHSMSIAREYTDLHFRGEYWQAPEQYRDLTRLSVYSVPRHSEYPFLDPHWIVRADGRREVGPNAVPVFGPYAYSLGRNIADMLPKIIESSATGARKVFFDRQFLSLASTELKSSLSKTAMINRVREFLPALKPSAFTERGTAGIRSSVIDSEGKFVPDTLILKRDSSVHVLNYNSPGATGALPMAAKVAMQVIEAGVLATTSTGKALTMWDPAEIALRMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNJ6</accession>
    <name>A0A075MNJ6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Restriction endonuclease type IV Mrr domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699377.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNJ6"/>
    <dbReference type="GeneID" id="41596205"/>
    <dbReference type="KEGG" id="nev:NTE_00300"/>
    <dbReference type="HOGENOM" id="CLU_1598933_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="166" mass="17915" checksum="1C359E06A7F0906F" modified="2014-10-29" version="1">MAAPAPATNVLTDSGFLSGVQDWINTNIGRIKLMWPLKGGWELWTQAEIAAYFISKNPLFDILREQPVYVNKGQAADFLINNSTVPATSGKIIVELKCQSKENATTFVAGVLSDLQKLSTIDPTFKGTQLLCLGIFFDQSAGNKLGSQGFGIAIIGSEVGLAWKYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNS1</accession>
    <name>A0A075MNS1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700001.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNS1"/>
    <dbReference type="STRING" id="1459636.NTE_01118"/>
    <dbReference type="GeneID" id="41596932"/>
    <dbReference type="KEGG" id="nev:NTE_01118"/>
    <dbReference type="HOGENOM" id="CLU_2857207_0_0_2"/>
    <dbReference type="OrthoDB" id="384548at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="60" mass="6931" checksum="C18A2A2C76EE21C7" modified="2014-10-29" version="1">MSKETKNPTKRDQALNDATEGQFGKEPRPEPEPNVGKRKDPSRNAKDAREKANRERYYAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNV3</accession>
    <name>A0A075MNV3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_00737</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_075054796.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNV3"/>
    <dbReference type="STRING" id="1459636.NTE_00737"/>
    <dbReference type="GeneID" id="41596589"/>
    <dbReference type="KEGG" id="nev:NTE_00737"/>
    <dbReference type="eggNOG" id="arCOG01580">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091233_5_3_2"/>
    <dbReference type="OrthoDB" id="14434at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043200">
        <property type="term" value="P:response to amino acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053483">
        <property type="entry name" value="HTH-Lysine_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019885">
        <property type="entry name" value="Tscrpt_reg_HTH_AsnC-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040947">
        <property type="entry name" value="trans_reg_LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30154">
        <property type="entry name" value="LEUCINE-RESPONSIVE REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30154:SF50">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR, ASNC FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00519">
        <property type="entry name" value="HTH_ASNC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="6"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF82815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="142" mass="15446" checksum="82BF40BB48B769D3" modified="2014-10-29" version="1">MSISNMDETDEKIIRILQADSRKAFVDIANEIGLSESAVRRRVKNLTDSGIVKRFTIELGASDKTSAITLISVSSTADTSAVSQRLMKLAGVEVVYEITGQYDIAAIIAAPAIVEINKCIDDIRKIEGVSDTNTVIILKTMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNZ5</accession>
    <name>A0A075MNZ5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00797</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNZ5"/>
    <dbReference type="STRING" id="1459636.NTE_00797"/>
    <dbReference type="KEGG" id="nev:NTE_00797"/>
    <dbReference type="HOGENOM" id="CLU_2930024_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="60" mass="6796" checksum="669EE764B2AC9DD6" modified="2014-10-29" version="1">MRQQLCRNQVQERGGYLGEIVVPTRKDAECLSKAIDMHAPAAPELVRDILMTYKARPLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MP79</accession>
    <name>A0A075MP79_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator, AsnC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_01277</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MP79"/>
    <dbReference type="KEGG" id="nev:NTE_01277"/>
    <dbReference type="eggNOG" id="arCOG01580">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091233_5_4_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043200">
        <property type="term" value="P:response to amino acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30154">
        <property type="entry name" value="LEUCINE-RESPONSIVE REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30154:SF34">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR AZLB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="29"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF83346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="186" mass="21108" checksum="1F24F053A58D6A4A" modified="2014-10-29" version="1">MFWRRNRKRITFINTGAKGYGGRESLHKFDELDMRILSELTRDASISVPRLSKKLNINASVLYSRIKRLSKRSLVKKFTVVVNESMLGINVKATVGINRDPKLKEPIHGELLKIPEVRSVSEVTGRFDMIVTVSAHTLEELHNVVIERIGKIEGIQNTETFVEMQRTEKEPLYTTQATATAAGISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MP85</accession>
    <name>A0A075MP85_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative signal-transduction protein containing cAMP-binding and CBS domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_00894</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699833.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MP85"/>
    <dbReference type="STRING" id="1459636.NTE_00894"/>
    <dbReference type="GeneID" id="41596734"/>
    <dbReference type="KEGG" id="nev:NTE_00894"/>
    <dbReference type="eggNOG" id="arCOG00601">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040681_12_1_2"/>
    <dbReference type="OrthoDB" id="65817at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051257">
        <property type="entry name" value="Diverse_CBS-Domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43080:SF2">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43080">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN CBSX3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="12"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="77"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF82970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="167" mass="18348" checksum="D801B2A6FC1F0E36" modified="2014-10-29" version="1">MSIETIPISSIMTKEVRTAGEGQTLRTVVEIMDKNDIGSVVIVDNKGSPSGIITERDIVRLVGSPKTSFAAAAKSVMKKPVVTADTMMSLKDALQTMQSKNIRRLPVVEKGKMVGIVTDKDIFRAILKSQELVSSTIGDSVLIEYRPIYERLSEFMLSEIYQPQGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPB5</accession>
    <name>A0A075MPB5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, ArsR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00978</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPB5"/>
    <dbReference type="STRING" id="1459636.NTE_00978"/>
    <dbReference type="KEGG" id="nev:NTE_00978"/>
    <dbReference type="HOGENOM" id="CLU_097806_0_3_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38600">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38600:SF1">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12840">
        <property type="entry name" value="HTH_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="15"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="114" mass="13794" checksum="03C3763FDCBC0A8F" modified="2014-10-29" version="1">MLYKYNMSRDRRHDLTLKALGNARRREMLDLLRERPRTTGELCDLFFKKLDRCTVMQHLGVLERADLIIVKRKGRHRWNYINPLPIKELHDRWICEYAAGTVDLLARMKREIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPU2</accession>
    <name>A0A075MPU2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase, aryl-alcohol dehydrogenase like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPU2"/>
    <dbReference type="STRING" id="1459636.NTE_01072"/>
    <dbReference type="KEGG" id="nev:NTE_01072"/>
    <dbReference type="eggNOG" id="arCOG01617">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_4_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19101">
        <property type="entry name" value="AKR_unchar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43147:SF2">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43147">
        <property type="entry name" value="PROTEIN TAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="1">
        <location>
            <begin position="28"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="348" mass="39356" checksum="E6C5ED575517B063" modified="2014-10-29" version="1">MQIIYINCVPSDTKGVETAALGDLKVCRILNGMWQVAGGHGRIEQKRAIDEMMAYHDSGFTSWDLADIYGPAEDFIGDFRKRLAEEKGAGELAKMQAFTKFVPEPARMTKAVVEQAIERSRRRMGVESIDLVQFHWWDYANPAWLDALVHLSELRDAGKIRNVGLTNFDTDHMQDMADAGIRIASNQVQYSIIDQRPQVKMQEFCKKNNVVIFAYGTMCGGLLSEKYLGKSEPSSAQLDTLSLRKYKKMIDAWGGWKLFQELLTALKQVATKYNASIANVTARYILDRPAVAGVIIGARLGIAEHRQDNARVFELRLDEEDREKIEAVTARSRNLFELIGDCGDEYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQ21</accession>
    <name>A0A075MQ21_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01598</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQ21"/>
    <dbReference type="KEGG" id="nev:NTE_01598"/>
    <dbReference type="HOGENOM" id="CLU_3130669_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="49" mass="5538" checksum="3C02B7DC94C9F113" modified="2014-10-29" version="1">MYATSTASTPSHNNTSARIMLQMFRLFYDDALVSAMQNYYWINGISALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQ58</accession>
    <name>A0A075MQ58_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Riboflavin kinase</fullName>
            <ecNumber evidence="5">2.7.1.161</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">CTP-dependent riboflavin kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">CTP:riboflavin 5'-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Flavokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">NTE_01635</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>riboflavin + CTP = CDP + FMN + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25021"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:57986"/>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="2.7.1.161"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (CTP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the archaeal riboflavin kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.161" evidence="5"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700420.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQ58"/>
    <dbReference type="STRING" id="1459636.NTE_01635"/>
    <dbReference type="GeneID" id="41597411"/>
    <dbReference type="KEGG" id="nev:NTE_01635"/>
    <dbReference type="eggNOG" id="arCOG01904">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088476_0_0_2"/>
    <dbReference type="OrthoDB" id="30955at2157"/>
    <dbReference type="UniPathway" id="UPA00276">
        <property type="reaction ID" value="UER00929"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008531">
        <property type="term" value="F:riboflavin kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009398">
        <property type="term" value="P:FMN biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.30">
        <property type="entry name" value="Riboflavin kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039063">
        <property type="entry name" value="RibK_CTP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023602">
        <property type="entry name" value="Riboflavin_kinase_CTP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023465">
        <property type="entry name" value="Riboflavin_kinase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40706">
        <property type="entry name" value="RIBOFLAVIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40706:SF1">
        <property type="entry name" value="RIBOFLAVIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01982">
        <property type="entry name" value="CTP-dep_RFKase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82114">
        <property type="entry name" value="Riboflavin kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0288">FMN</keyword>
    <keyword evidence="12 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 19" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Riboflavin kinase" evidence="18">
        <location>
            <begin position="101"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00033116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF01982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="AIF83696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="237" mass="26395" checksum="E61B7A3C56A1BD39" modified="2014-10-29" version="1">MPEIKLQHILTMVQLLSKGARHNFVEVTTADLGRNIGRSQQAASKHLLDLEMAGYIERVRRGQKFAVRVTDKGNTEIQSLFASLKSALESAPAAIDFEGSVVSGMGEGAYYMSLEGYKKQFLEKLGYEPYPGTLNVRLTDPVYMNARRELGRHPSIFLEGFSDGTRTYGWVKCYRASINDGAMENAAVLVLERTHYDDSMLEVIAPVSIKDAVGIKNGDRIKVQVRIDNNNSPHQMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQ82</accession>
    <name>A0A075MQ82_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleotidyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00967</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699888.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQ82"/>
    <dbReference type="GeneID" id="41596797"/>
    <dbReference type="KEGG" id="nev:NTE_00967"/>
    <dbReference type="eggNOG" id="arCOG08732">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_951889_0_0_2"/>
    <dbReference type="OrthoDB" id="10119at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="310" mass="34190" checksum="926C7392A1E916EE" modified="2014-10-29" version="1">MLVPALGMVLVPKAVRDYVAGLPHPTGLMGCRAAGEMSHPCCEYDIAVFGQGENRLEKVDGHIIELVHISRPKDHLVALRDMSIIKDSKAFSISSTLKGIADEKDEKFKKALFASGRKALVSSLFCQQKFKLIAKKKDDEQQQVAGAMWLKMASYHLVAGTLAIFGARPMPLHELAQARQADLPADAADGVQAALECIGIERATRPAIARSTEAMMELKSKDYDKELVRVKVEHLLEKSMLADCYYYAGRVAAENLATRNDAFFRRYAKLVQLAMDLSSDEQRLEKLRKSLSLAAKSGLKTTVDDTTTFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQA7</accession>
    <name>A0A075MQA7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LAGLIDADG endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700160.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQA7"/>
    <dbReference type="GeneID" id="41597112"/>
    <dbReference type="KEGG" id="nev:NTE_01310"/>
    <dbReference type="eggNOG" id="arCOG03156">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1100915_0_0_2"/>
    <dbReference type="OrthoDB" id="65293at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016539">
        <property type="term" value="P:intein-mediated protein splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.10">
        <property type="entry name" value="Homing endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027434">
        <property type="entry name" value="Homing_endonucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006142">
        <property type="entry name" value="INTEIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004042">
        <property type="entry name" value="Intein_endonuc_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004860">
        <property type="entry name" value="LAGLIDADG_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14528">
        <property type="entry name" value="LAGLIDADG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00379">
        <property type="entry name" value="INTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55608">
        <property type="entry name" value="Homing endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50819">
        <property type="entry name" value="INTEIN_ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DOD-type homing endonuclease" evidence="1">
        <location>
            <begin position="52"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="252" mass="29255" checksum="2EF7DCA4ADFC1CBF" modified="2014-10-29" version="1">MKSKSLSRQSTVHLIKDKFDIPLSTCYLWFSGSQSPHGALGKLKTRENLFYVLGVLLGDGYAYNWQSSYKVGILVKDESFAKKFAERLSTCTGGKVTAYPSRKRNLWFVKVGNHELFTLFKDFKSNLNLVKDETISKAHALQFIEGFFDAEGCVKVVKEKARKTPKICLDFTNTNYEVLEVVQKLLRTSLNIESGFSVQHDKRPNRKPVYHLRIYKKDYIRIFFENMQTIKLNKEKALHLKKWLQRDVTVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQB2</accession>
    <name>A0A075MQB2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00998</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQB2"/>
    <dbReference type="KEGG" id="nev:NTE_00998"/>
    <dbReference type="HOGENOM" id="CLU_3056947_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="53" mass="5823" checksum="CEE9DC3940E793E9" modified="2014-10-29" version="1">MPKVIGKKKKKTKNPRDKKTSEAASVATDMTSSTIASVSVCLRSTVFLRRKVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQB7</accession>
    <name>A0A075MQB7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1326 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01003</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQB7"/>
    <dbReference type="STRING" id="1459636.NTE_01003"/>
    <dbReference type="KEGG" id="nev:NTE_01003"/>
    <dbReference type="eggNOG" id="arCOG11393">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092801_1_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009758">
        <property type="entry name" value="DUF1326"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014581">
        <property type="entry name" value="UCP033303"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07040">
        <property type="entry name" value="DUF1326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033303">
        <property type="entry name" value="UCP033303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="235" mass="25572" checksum="E1CFE3B910024761" modified="2014-10-29" version="1">MNIKILCHLQRNPDPLTYNLISLRQDDPDTLSAPQSWKIEGDYFEACNCDVVCPCVFMGDPDRGECDVTVAWHIQKGNFGNTRLDGLNVVAVFHAPGNMFTGPKWKAALYLDERANKDQADALVKIYSGQAGGFFGVAAGFIGDMAGVRSVPIKFEADGRKRSLQIPSAMDVAIEGIASGEGQNKETTIENVPMTVAPGFPAVVAKSVKHSYSDHGMKWDNSGKNGFYSKFAYSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQT2</accession>
    <name>A0A075MQT2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF371 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01841</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQT2"/>
    <dbReference type="STRING" id="1459636.NTE_01841"/>
    <dbReference type="KEGG" id="nev:NTE_01841"/>
    <dbReference type="eggNOG" id="arCOG04171">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_135994_0_0_2"/>
    <dbReference type="OrthoDB" id="9265at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.630">
        <property type="entry name" value="mth639 domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007171">
        <property type="entry name" value="DUF371"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023131">
        <property type="entry name" value="Mth639-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40696:SF1">
        <property type="entry name" value="DUF371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40696">
        <property type="entry name" value="DUF371 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04027">
        <property type="entry name" value="DUF371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="138" mass="15340" checksum="FED38DBD6878E37D" modified="2014-10-29" version="1">MQDDIAFFGHPNVQSLHARTVEITKEEHLTLRGDCIIGVNAEKACADIDEKIKRKLARSDSHVKIEIIVGNDVYTISGAGDERLTLQNKHDIVIRKTNFVCPRTLSVRCDKASSDIPRGMVKALQDPGTKGIFRVTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQX4</accession>
    <name>A0A075MQX4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PPOX class probable F420-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_01154</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700024.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQX4"/>
    <dbReference type="STRING" id="1459636.NTE_01154"/>
    <dbReference type="GeneID" id="41596966"/>
    <dbReference type="KEGG" id="nev:NTE_01154"/>
    <dbReference type="eggNOG" id="arCOG00516">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123922_3_0_2"/>
    <dbReference type="OrthoDB" id="10511at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070967">
        <property type="term" value="F:coenzyme F420 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019920">
        <property type="entry name" value="F420-binding_dom_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052019">
        <property type="entry name" value="F420H2_bilvrd_red/Heme_oxyg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03618">
        <property type="entry name" value="Rv1155_F420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35176">
        <property type="entry name" value="HEME OXYGENASE HI_0854-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35176:SF6">
        <property type="entry name" value="HEME OXYGENASE HI_0854-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="PNPOx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine 5'-phosphate oxidase N-terminal" evidence="2">
        <location>
            <begin position="42"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF83227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="178" mass="19912" checksum="24FACE25166281EB" modified="2014-10-29" version="1">MKDKESDFSVDIVNDLPNSAILEPRQENVGASRSVTYISKEDITKLFVGRNLAFISTLSRDGSPTVTPVWADIEDDIILINSFEGSAKVRNARRDPRVALAIVETYNTYNMASIKGRVIEVTAEGADAHLHKLAKKYLGIGRYYYRTPKNKRVIIKIKPEKMIGISIHPASLFLAYTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MR72</accession>
    <name>A0A075MR72_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SnoaL-like domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700710.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MR72"/>
    <dbReference type="GeneID" id="41597751"/>
    <dbReference type="KEGG" id="nev:NTE_02004"/>
    <dbReference type="HOGENOM" id="CLU_153137_0_0_2"/>
    <dbReference type="OrthoDB" id="13157at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="17"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="126" mass="14250" checksum="FA2AC1EB90F39ED3" modified="2014-10-29" version="1">MQKNIGSVNNAKQVVMSFVEALGNQDYKSARSYASDNMSFLGPLASHDSADAYFKDMERLRLPKFEIKKVVADGNDVCLFYDLNVGTPPVAVFVCGWYHVNDEGKISSLRVVFDPRHFLQQQQQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRB5</accession>
    <name>A0A075MRB5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flavin-dependent dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01288</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700142.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRB5"/>
    <dbReference type="STRING" id="1459636.NTE_01288"/>
    <dbReference type="GeneID" id="41597091"/>
    <dbReference type="KEGG" id="nev:NTE_01288"/>
    <dbReference type="eggNOG" id="arCOG00570">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074748_0_0_2"/>
    <dbReference type="OrthoDB" id="6062at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050407">
        <property type="entry name" value="Geranylgeranyl_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42685:SF21">
        <property type="entry name" value="DEHYDROGENASE (FLAVOPROTEIN)-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42685">
        <property type="entry name" value="GERANYLGERANYL DIPHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="340" mass="38860" checksum="164DAFC4BE9080BE" modified="2014-10-29" version="1">MKVAVVGIGVAGAYLMNRLSDMRDVRVTGFERMPEDQHDAVCAWATCENVMSGLAKNCGLNFDDYVLHQGRHMKVDLNSDDYVDLKLKGMVSYDKLKLIQDMIKGTEIKFGRAPRKEELEPDFDLIIDATGFHRNYLPRLENELWIPCVQYKVRYKPGREPFDDFYLKAFPSMTGYFWYFPLGNGYAHIGAGDFAKAHNPLVQEFLKKHECETIKKVGRPVRISPPANCEPFTDGRKCVGVGESIGTVFALLGEGIIPSTWCADLFVQNMDDLQAYRDAVMKKFQVYSLIFKFVQLKIQGKFNMVRHAGDMLKIYRHMKGEEDRYGMAVRMADMLKVSQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRI0</accession>
    <name>A0A075MRI0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rhodanese-related sulfurtransferase</fullName>
            <ecNumber evidence="3">2.8.1.1</ecNumber>
            <ecNumber evidence="3">2.8.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_01349</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.8.1.1" evidence="3"/>
    <dbReference type="EC" id="2.8.1.2" evidence="3"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRI0"/>
    <dbReference type="STRING" id="1459636.NTE_01349"/>
    <dbReference type="KEGG" id="nev:NTE_01349"/>
    <dbReference type="eggNOG" id="arCOG02019">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031618_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016784">
        <property type="term" value="F:3-mercaptopyruvate sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01448">
        <property type="entry name" value="TST_Repeat_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01449">
        <property type="entry name" value="TST_Repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051126">
        <property type="entry name" value="Thiosulfate_sulfurtransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43855">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43855:SF1">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="29"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="167"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF83417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="270" mass="29997" checksum="7F74C29637405723" modified="2014-10-29" version="1">MNYKIRVQTNASLMTLITVESKWLAANLDNPNVVILDTRGQMLYRFGHIKNALSLGMEMVVTVAPNGANLVIEGAQAEKVFGSYGIDDSKKVVVYGEQDDPAAARVAWSIMYHGHPDVALLDTGFSVWKHLGLPVTRDAAQAKPAQFTSKPKPEIRIDAEAIKAKAGDPSFVVVDARTRQEHMQARIPNSVLHDWEQGVGANGSAFLSPEELKKEFESKGITPDKEVVCYCHSGVRASHKYMQFRLAGYEKVRLYDGSIIDWAMRRNPIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRI7</accession>
    <name>A0A075MRI7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01359</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700200.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRI7"/>
    <dbReference type="STRING" id="1459636.NTE_01359"/>
    <dbReference type="GeneID" id="41597157"/>
    <dbReference type="KEGG" id="nev:NTE_01359"/>
    <dbReference type="eggNOG" id="arCOG03737">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1302663_0_0_2"/>
    <dbReference type="OrthoDB" id="10005at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="79"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="211" mass="23089" checksum="778BE7B7BD9201AC" modified="2014-10-29" version="1">MTAEERLEKKILSAGSAGAKKADLRKEFGEIDAALESLVSKGQVFVDKRSSAYYCFHKDHYVQSLLNTDPRFRLTYDMIKSLEETVSASNREVSRAVEALANNISNLARLVSERANDRSVPASAAPARSISVSDFKKEFDSALASSASSIGWVELAKVRSDVCGRCGITGDDFYRLVSELTGQYQDKYELSTGGGEGVMVRGLLHGFVRCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRL6</accession>
    <name>A0A075MRL6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02131</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRL6"/>
    <dbReference type="STRING" id="1459636.NTE_02131"/>
    <dbReference type="KEGG" id="nev:NTE_02131"/>
    <dbReference type="HOGENOM" id="CLU_2299213_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="100" mass="11241" checksum="3517542639FC77A6" modified="2014-10-29" version="1">MTTLPINGTYTTIIAMQINGLVSKLQKVHAVQMGKENIAFNAGFSRMLFRAVCENNPKTTENWRSIMSSYHPALSGLSSEEISAILSLFIYSTVHRRKNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRN7</accession>
    <name>A0A075MRN7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phenylalanine--tRNA ligase</fullName>
            <ecNumber evidence="4">6.1.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">NTE_01418</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SR1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="4"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRN7"/>
    <dbReference type="STRING" id="1459636.NTE_01418"/>
    <dbReference type="KEGG" id="nev:NTE_01418"/>
    <dbReference type="eggNOG" id="arCOG00412">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020279_3_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009328">
        <property type="term" value="C:phenylalanine-tRNA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00769">
        <property type="entry name" value="PheRS_beta_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.40.10:FF:000003">
        <property type="entry name" value="Phenylalanine--tRNA ligase beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.40.10">
        <property type="entry name" value="Phenylalanyl-trna Synthetase, Chain B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005146">
        <property type="entry name" value="B3/B4_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045060">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004531">
        <property type="entry name" value="Phe-tRNA-synth_IIc_bsu_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041616">
        <property type="entry name" value="PheRS_beta_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005147">
        <property type="entry name" value="tRNA_synthase_B5-dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00471">
        <property type="entry name" value="pheT_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947:SF0">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE BETA CHAIN AND LEUCINE-RICH REPEAT-CONTAINING PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03483">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03484">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17759">
        <property type="entry name" value="tRNA_synthFbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00873">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00874">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51483">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B5" evidence="13">
        <location>
            <begin position="272"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AIF83482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="551" mass="59873" checksum="12F76FFD3A60593B" modified="2014-10-29" version="1">MPVVNVALDRLKKFLPGVKVEKALDMLPFVGLDIEGIDGDVVRVEYNPNRPDFSSDYGIARALAGLVGKETGMPKFRLSGKSGLAVKVDRSVKKVRPFVVALAAKNGKLDDETIKQLISMQEDLHNGVGRRRKKASIGMHNLDAIKFPVRYTTASSDYSFVPLAGSKEQTVEQILQETETGRVYGHLLAGAEKYPVIIDSAGTTLSLPPVINGEATKVDEKCKNLFVEVTATDKKAADDALAVIAVTLFDAGFQIKTVTIDDNGKKLETPDAATRKMSVGAGYVNEILGLNLTAKEIAECLKKSRLDAKATGNKIACTIPRYRTDITHEIDLAEEVAIGYGIYRMEPNFPVSPTSGQRSALSSYFSAIRQTMTGLGMLESFNFSLTSREVQYSLCGRPEYDILAVDGTKSIEHEVLRSSLVPSLLQSLSRNVHEEYPQRLFEIGKTFHRHDDGGKIVERWQVAAVVAHGEAGYTEIKSAMQALLSSGFGVSAITTKASDDPLYIKGRCAKISIDKGVVGTIGEITPLAIDNFKLRVPVAAFEIDLSALLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRQ6</accession>
    <name>A0A075MRQ6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">YdhG-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699165.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRQ6"/>
    <dbReference type="STRING" id="1459636.NTE_00010"/>
    <dbReference type="GeneID" id="41595964"/>
    <dbReference type="KEGG" id="nev:NTE_00010"/>
    <dbReference type="HOGENOM" id="CLU_2353090_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159888">
        <property type="entry name" value="YdhG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="96" mass="10663" checksum="72DE4E19B0627CD7" modified="2014-10-29" version="1">MPKRTVSPEEILEGHAPEVRTITNRLRAIISKTVEGASEAGYPGWHAIGYRHPAVGYFCGIFPAKDRVKLYFEYGHPFLTRTGSCLEGPRCGRDAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRS0</accession>
    <name>A0A075MRS0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Galactose oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRS0"/>
    <dbReference type="KEGG" id="nev:NTE_00025"/>
    <dbReference type="eggNOG" id="arCOG07536">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004253_10_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF24">
        <property type="entry name" value="GALACTOSE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00501">
        <property type="entry name" value="KELCHREPEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="349" mass="36375" checksum="E4F3B60DDDB2D010" modified="2014-10-29" version="1">MPARQTYVIVGSSMAAAVVIAIIVVLSITANSGISSSGVVATRLSESDTKSSSLAWTEGRLLPTSRTEVAGAAVDGKIYIIGGFDRTGKVVPTVEVYDPGTDKWNTAAPLPHPLHHAAAASYNGTLYVVGGYLEDNTPSDKLLAYDPKTDEWRQDDLAPMLTARGALAASFVNGTLYAVGGVNASFGSPAAGPLATNEAYDPKTNSWSQKAPMPTPRQHLAAAVLDSKLYAIGGRIDSLASNLASNEAYDPKSDAWTRLEPMPTKRGGIAAAAVGNAIYVFGGESPEGTFRNNEKYDTETSSWTRAPEMPTARHGLAAVALGNKIYVIGGGPQPGLTVSGANEIFSSVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRT0</accession>
    <name>A0A075MRT0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Flavin-dependent dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01739</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700503.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRT0"/>
    <dbReference type="STRING" id="1459636.NTE_01739"/>
    <dbReference type="GeneID" id="41597509"/>
    <dbReference type="KEGG" id="nev:NTE_01739"/>
    <dbReference type="eggNOG" id="arCOG00570">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074748_0_0_2"/>
    <dbReference type="OrthoDB" id="6062at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050407">
        <property type="entry name" value="Geranylgeranyl_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42685:SF21">
        <property type="entry name" value="DEHYDROGENASE (FLAVOPROTEIN)-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42685">
        <property type="entry name" value="GERANYLGERANYL DIPHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="342" mass="39456" checksum="8B67EFDD59560484" modified="2014-10-29" version="1">MRFAIAGAGVAGSYLGNMLQRRGHEVQVFESSRPENHWPVCAWGASRHMLSKFSEKAGLDFKDYIMHIGQRLRMDLPAGKVEYLDLKGLVTYDKHRWEHDLMQGLEIKYGTKVTKEDFPFEKYDHVLDCTGLHRTLLPKSGEDFLIPAYEYLLEEVKGENEFYTIGYKGAKGYFWYFPLGDGKGYMGAGDVEKKYHGIKEFFEQHPEAKIVKKIGRPIRLAPPKKMEPFFDGNVVGVGESIGCVFPMLGEGIIPSLLCCDFFLDALDDRKGLDAKKYRKKVLSYFDYYDDVYRIVRLKMDGKLSTIRHANLLMSMYRHMKKEESRFGFEVSLEKMNRLVNAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRV7</accession>
    <name>A0A075MRV7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRV7"/>
    <dbReference type="KEGG" id="nev:NTE_00060"/>
    <dbReference type="eggNOG" id="arCOG01995">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113182_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002798">
        <property type="entry name" value="SpoIIM-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01944">
        <property type="entry name" value="SpoIIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="188" mass="20398" checksum="9B075FE04CF5CA4B" modified="2014-10-29" version="1">MGRFYSNNTVSRFNIRRRLLFVAIGAIVFFAAYSAGAAVQLTPTEAKEVRDSFSSQIEDINDVGIFVNNVKIALGMFVPGLGIGLGVFSGYATGNVFAALAQDSPVLQGIPPQLILITPFGVMEVITYGLAMSRSGMLVYYFAKKRPWREYVAPTLIELGIAAAILLAAAAIEWWMIQELGGTNFEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRW9</accession>
    <name>A0A075MRW9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NADH:ubiquinone oxidoreductase chain I-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NTE_00070</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_075055106.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRW9"/>
    <dbReference type="STRING" id="1459636.NTE_00070"/>
    <dbReference type="GeneID" id="41596020"/>
    <dbReference type="KEGG" id="nev:NTE_00070"/>
    <dbReference type="eggNOG" id="arCOG00291">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2340274_0_0_2"/>
    <dbReference type="OrthoDB" id="5583at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050572">
        <property type="entry name" value="Fe-S_Ferredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43687">
        <property type="entry name" value="ADENYLYLSULFATE REDUCTASE, BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43687:SF6">
        <property type="entry name" value="L-ASPARTATE SEMIALDEHYDE SULFURTRANSFERASE IRON-SULFUR SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="5"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="44"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF82154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="97" mass="10690" checksum="0F68E277268772C7" modified="2014-10-29" version="1">MPVAILPDVSEQHCIGCALCVEICTALGPDVLRVKPVEGWKRGKAFVFYPERCISDGACIGVCPTKAIFWMRPMDYTPGQPVPLKKHGLFVKGWEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRX8</accession>
    <name>A0A075MRX8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cache domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NTE_01509</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700320.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRX8"/>
    <dbReference type="STRING" id="1459636.NTE_01509"/>
    <dbReference type="GeneID" id="41597298"/>
    <dbReference type="KEGG" id="nev:NTE_01509"/>
    <dbReference type="eggNOG" id="arCOG02362">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_846223_0_0_2"/>
    <dbReference type="OrthoDB" id="11465at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033479">
        <property type="entry name" value="dCache_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029151">
        <property type="entry name" value="Sensor-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02743">
        <property type="entry name" value="dCache_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103190">
        <property type="entry name" value="Sensory domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Cache" evidence="7">
        <location>
            <begin position="36"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF83572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="328" mass="35141" checksum="89AD2E57F0921B49" modified="2014-10-29" version="1">MTLLLSGKARNLAAYSVAVALAIIILAAVGTASINALEQEIRKKEASDVRALAIATEGKLSTIASLMEATGSLPQVTAGAPYVAQMTKELHGVPQNVDAEKRQVAQSVLSKSQDIEAIAFILPNGEMYMEEPYYRQMNLTSTNFAFRDYFKGAVNSGSTYLGEVYISASSGASASAVAVPVTSGDELKGVWIGIVHLQNLDKFAKDMFDNDDGRRFTYADQHGHEVVYSNKIVPSLEEASKPLAEMDVYKKAISGESGVAVESIGGKEMLVAYHPVRVPGATWAVFSIQPYDSVIKPVQDLRMQTYYAIAIAAAAGAALAIVIAKRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MS01</accession>
    <name>A0A075MS01_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">4-hydroxybenzoate polyprenyltransferase-like prenyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NTE_01529</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MS01"/>
    <dbReference type="STRING" id="1459636.NTE_01529"/>
    <dbReference type="KEGG" id="nev:NTE_01529"/>
    <dbReference type="eggNOG" id="arCOG00476">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_846262_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1780">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050475">
        <property type="entry name" value="Prenyltransferase_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42723">
        <property type="entry name" value="CHLOROPHYLL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42723:SF1">
        <property type="entry name" value="CHLOROPHYLL SYNTHASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF83592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="334" mass="36272" checksum="B15975EDF5672E88" modified="2014-10-29" version="1">MHSSSYPELGRKQQRQEENRNASANNVSFLRSQLILFQSRQKWGLVYSLATVVGLFCLPGALGVFGQQQQTLPILDVVQKSAPLPFISLLITIGMYVLNDLADSDLDKANGKKRPIPSGLVSKRQALEFVMMTNGIAVILSLVTLNVVTMVMVVPMLVIGILYSSRKAAFENKFVVKNVSIAVFYMLCALLGMTSGYTLGLAVDNPFVAIRAAAALGIMVFISSILNDLGDIEGDRQAGRRTIPIVMGEQGTIKMAIALAAGLFAISWLTYWLSGGSGLVTAVLTTLFSALIGARIANLRKGVNDVDFLRRQHKNFVPLHFLLQLFLFGGGALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MS03</accession>
    <name>A0A075MS03_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative redox protein, regulator of disulfide bond formation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_02237</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfur carrier protein TusA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700894.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MS03"/>
    <dbReference type="STRING" id="1459636.NTE_02237"/>
    <dbReference type="GeneID" id="41597957"/>
    <dbReference type="KEGG" id="nev:NTE_02237"/>
    <dbReference type="eggNOG" id="arCOG02062">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_165255_1_2_2"/>
    <dbReference type="OrthoDB" id="45650at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00291">
        <property type="entry name" value="SirA_YedF_YeeD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.40">
        <property type="entry name" value="TusA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001455">
        <property type="entry name" value="TusA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036868">
        <property type="entry name" value="TusA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33279">
        <property type="entry name" value="SULFUR CARRIER PROTEIN YEDF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33279:SF6">
        <property type="entry name" value="SULFUR CARRIER PROTEIN YEDF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01206">
        <property type="entry name" value="TusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64307">
        <property type="entry name" value="SirA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01148">
        <property type="entry name" value="UPF0033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF0033" evidence="2">
        <location>
            <begin position="13"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF84291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="82" mass="9307" checksum="F5993A510186C332" modified="2014-10-29" version="1">MSTSSSSSPTKSIDVRGLYCPEPVFRTKMEIERLSIGDVLKIVADDPESEEDISRWVKRNGHELLAINKTQKDLEFIIKKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MS61</accession>
    <name>A0A075MS61_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutamine phosphoribosylpyrophosphate amidotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_02328</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700962.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MS61"/>
    <dbReference type="STRING" id="1459636.NTE_02328"/>
    <dbReference type="GeneID" id="41598044"/>
    <dbReference type="KEGG" id="nev:NTE_02328"/>
    <dbReference type="eggNOG" id="arCOG00093">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_596687_0_0_2"/>
    <dbReference type="OrthoDB" id="5976at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00352">
        <property type="entry name" value="Gn_AT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11907">
        <property type="entry name" value="AMIDOPHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="3">
        <location>
            <begin position="2"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF84381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="458" mass="51197" checksum="AD15987D1EA3F496" modified="2014-10-29" version="1">MAGIVAIYNHGTEPRQAVVYYLAHAMRMLQHRGKAYWRMMVGSGSAGAEGSLPADDAILKVAHREKLAGVCGIGYLLKRSPPFASMQSAQVAFDGFFVDTEKLHLHPYIGPAKHSDSLFKIYHIFVTLLKKDPDRAVEFLDRHLRGNLLVKLEDEVYAYRDSTGFKPLVTASRKDRTLNIVASENSLRASLIDMEFSEIKPGQLLKLSKRAGLEVIATSHDSKLMMDPFEFIRESNVVATLGGKSIYEIRKSIGKEQANMLSLDLKVADLDSAYAEPDYTRPMALGFGLAYRKHFPPFDIAEGVIKDRYDDSDNMIDFSEQDSKNKLLTTGRSLKFVMQPLVKGKNIATVQGTIQTSATARETIYYLKNAGARRIDVVVSYVPTVDGRQVGLYTHNRDLVANKYVGEVSSINELNQNIAKELGADSVYYNSPSVLAKGIGVPEHNLWFPEWVRFLDYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSH3</accession>
    <name>A0A075MSH3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">tRNA-intron endonuclease</fullName>
            <ecNumber evidence="4">4.6.1.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_01681</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.6.1.16" evidence="4"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700458.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSH3"/>
    <dbReference type="STRING" id="1459636.NTE_01681"/>
    <dbReference type="GeneID" id="41597454"/>
    <dbReference type="KEGG" id="nev:NTE_01681"/>
    <dbReference type="eggNOG" id="arCOG01701">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114393_0_0_2"/>
    <dbReference type="OrthoDB" id="46045at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22363">
        <property type="entry name" value="tRNA-intron_lyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006677">
        <property type="entry name" value="tRNA_intron_Endonuc_cat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006678">
        <property type="entry name" value="tRNA_intron_Endonuc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036740">
        <property type="entry name" value="tRNA_intron_Endonuc_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006676">
        <property type="entry name" value="tRNA_splic"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00324">
        <property type="entry name" value="endA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21227">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21227:SF0">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01974">
        <property type="entry name" value="tRNA_int_endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02778">
        <property type="entry name" value="tRNA_int_endo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="tRNA-intron endonuclease catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55267">
        <property type="entry name" value="tRNA-intron endonuclease N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA intron endonuclease N-terminal" evidence="3">
        <location>
            <begin position="36"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA intron endonuclease catalytic" evidence="2">
        <location>
            <begin position="103"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF83742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="206" mass="23605" checksum="1D9848F95961179D" modified="2014-10-29" version="1">MSSPQQQQPFAEKQQQQAGEEVQPAAVVEARLAGAGKVLIEETRSQDELRTRGFGEREGQEYVLKPYEALYLLQAKRLTFAGKKDVTFDSLFEHLLKHDKNIMTKFLVYRDLRSRGYVAKEGFGFGDDFRVYERGEYEKKPAKYVVFGINEGANVTAKGFASAIEQIEKMGKEAVVAVIERRGEVIYYKASKMRFMQNKHDTFLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSL2</accession>
    <name>A0A075MSL2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyl-accepting chemotaxis protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700754.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSL2"/>
    <dbReference type="GeneID" id="41597799"/>
    <dbReference type="KEGG" id="nev:NTE_02063"/>
    <dbReference type="eggNOG" id="arCOG08689">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1656805_0_0_2"/>
    <dbReference type="OrthoDB" id="10484at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="159" mass="17649" checksum="3B42FF923697B149" modified="2014-10-29" version="1">MVKKKQASRAVVIAGFAAIAVLIGVMVMLQVSSAQNDEFKQKWDGIAVDTIALTREYQAEEGKWKAGQYDNATMAAIIDKYMPRYQSLIDRANALETPERYTDARSLLVKAIQAEKDSNEHFKAYLLTGNRAEYEKTLDLFSLSLKYSAEADAAMKAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSP5</accession>
    <name>A0A075MSP5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01741</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700504.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSP5"/>
    <dbReference type="STRING" id="1459636.NTE_01741"/>
    <dbReference type="GeneID" id="41597511"/>
    <dbReference type="KEGG" id="nev:NTE_01741"/>
    <dbReference type="HOGENOM" id="CLU_2695902_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="80" mass="9191" checksum="AA80A2311501987A" modified="2014-10-29" version="1">MQRRSKPVAKKAKKARKDEEQITVLLREILAELRRLNTNLERRQQTAAASAEPAEIEDAIDMEDDDENGDSGSEELEYFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSV1</accession>
    <name>A0A075MSV1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Isopropylmalate/citramalate/homocitrate synthase</fullName>
            <ecNumber evidence="8">2.3.3.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NTE_02176</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the alpha-IPM synthase/homocitrate synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.13" evidence="8"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700843.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSV1"/>
    <dbReference type="STRING" id="1459636.NTE_02176"/>
    <dbReference type="GeneID" id="41597900"/>
    <dbReference type="KEGG" id="nev:NTE_02176"/>
    <dbReference type="eggNOG" id="arCOG02092">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022158_0_1_2"/>
    <dbReference type="OrthoDB" id="6555at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07940">
        <property type="entry name" value="DRE_TIM_IPMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.260:FF:000001">
        <property type="entry name" value="2-isopropylmalate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000010">
        <property type="entry name" value="2-isopropylmalate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.270:FF:000003">
        <property type="entry name" value="2-isopropylmalate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013709">
        <property type="entry name" value="2-isopropylmalate_synth_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011830">
        <property type="entry name" value="LEU1_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054691">
        <property type="entry name" value="LeuA/HCS_post-cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036230">
        <property type="entry name" value="LeuA_allosteric_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02090">
        <property type="entry name" value="LEU1_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002085">
        <property type="entry name" value="PRK00915.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002086">
        <property type="entry name" value="PRK00915.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42880:SF2">
        <property type="entry name" value="(R)-CITRAMALATE SYNTHASE CIMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42880">
        <property type="entry name" value="HOMOCITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22617">
        <property type="entry name" value="HCS_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08502">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00917">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110921">
        <property type="entry name" value="2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="7">
        <location>
            <begin position="7"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF84230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="503" mass="54572" checksum="135FD8C561E223D4" modified="2014-10-29" version="1">MSGEEKVRIFDTTLRDGEQSPGVTVTPEQKVHIAQKLDELGVDAIEAGFPVVSTGEMYAVKTIANSGLKAEVCGLARAVDADIDAAIKCDLKYVHTFIATSDIHMQYKLKMTRDQVLERAVHAVEYAKKHGLRVEFSAEDATRSDRAFLIKVFSAVAQAGADRVDIPDTVGYAKPQDITELVREVKEATRLPISMHCHDDFGLAVANSIAGINAGAVCAHVTINGLGERAGNASLEEFVMALQCLYQKKHNINTQLLYETSKFVSNTMGIIVQPNKAIIGENAFGHESGIHTHGVLNNPLTYEPISPELVGRKRWLQAGKHAGAHGIRAMLEEFGINPTEEQLHAIVEKQKDIADKGKAITTSELLTIAGEVMHNSQFEERFKLYDFHILTGMNIIPTAVVRLNAEGKDLLASDTGVGPVDAALKAIQKIASDVASIKIREYRLDSISGGSDALAEVSVKVEDKNGNIVSARKANEDIVVASVEALMDAINKVLLKKVLYSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSV2</accession>
    <name>A0A075MSV2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydrofolate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02613</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701190.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSV2"/>
    <dbReference type="STRING" id="1459636.NTE_02613"/>
    <dbReference type="GeneID" id="41598308"/>
    <dbReference type="KEGG" id="nev:NTE_02613"/>
    <dbReference type="eggNOG" id="arCOG01490">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043966_1_0_2"/>
    <dbReference type="OrthoDB" id="7348at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="entry name" value="Dihydrofolate Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050765">
        <property type="entry name" value="Riboflavin_Biosynth_HTPR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38011:SF2">
        <property type="entry name" value="BIFUNCTIONAL DEAMINASE-REDUCTASE DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38011">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_8G06820)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="Dihydrofolate reductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bacterial bifunctional deaminase-reductase C-terminal" evidence="1">
        <location>
            <begin position="3"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="222" mass="24614" checksum="B2A9721712B3C570" modified="2014-10-29" version="1">MRKLVVLSFISLDGVMQAPGGPGEDPTGGFKHEGWVVGYIDDYLLKVMVKQMSKPFELLLGRKTYEIFAAHWPYVNSSEDPFAARINNAKKYVASKTITKLDWNNSELIQGDVWKEIKKLKEQEGPEIQVHGSGNLIQTLLKHDLVDELRLKIFPVTLGIGKRLFADGTIPAGFKLVESEISPSGVIIASYGRAGEVKTGSFGLETPSEAELARRKRLKEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSV9</accession>
    <name>A0A075MSV9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02191</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700855.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSV9"/>
    <dbReference type="STRING" id="1459636.NTE_02191"/>
    <dbReference type="GeneID" id="41597913"/>
    <dbReference type="KEGG" id="nev:NTE_02191"/>
    <dbReference type="eggNOG" id="arCOG02155">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1691591_0_0_2"/>
    <dbReference type="OrthoDB" id="381296at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="128"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="157" mass="17517" checksum="2625EC91397C7767" modified="2014-10-29" version="1">MELGNAKVYTSDKKSAGRVTRVDTEYFTTFKKGLTVDEEYRIPLDAILDVQTTEKSAVVKLALSREQLKHGYEILKGEPNSELVSGKAESELKIPFKKQVIHYEATKPLEENIAITPSKEGLPHDTQYSCDMCAEKFDDADSLQTHRADVHKGATGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSW6</accession>
    <name>A0A075MSW6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02206</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700867.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSW6"/>
    <dbReference type="GeneID" id="41597927"/>
    <dbReference type="KEGG" id="nev:NTE_02206"/>
    <dbReference type="HOGENOM" id="CLU_2985814_0_0_2"/>
    <dbReference type="OrthoDB" id="11308at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="65" mass="7242" checksum="F03339909E0DA87C" modified="2014-10-29" version="1">MSTAGSDGNNNDKIILSDDHRAAMAGWKARKEQLHRQQESVFKANDEAEKVNLVSLSKKKRETAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSY5</accession>
    <name>A0A075MSY5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator with CheY-like receiver, AAA-type ATPase, and DNA-binding domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_00367</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSY5"/>
    <dbReference type="STRING" id="1459636.NTE_00367"/>
    <dbReference type="KEGG" id="nev:NTE_00367"/>
    <dbReference type="eggNOG" id="arCOG02391">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1136018_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00156">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050595">
        <property type="entry name" value="Bact_response_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041226">
        <property type="entry name" value="NitrOD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44591">
        <property type="entry name" value="STRESS RESPONSE REGULATOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44591:SF21">
        <property type="entry name" value="TWO-COMPONENT RESPONSE REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18550">
        <property type="entry name" value="NitrOD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="115"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF82449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="244" mass="27629" checksum="6A7797997FC15981" modified="2014-10-29" version="1">MKCEIVENDTDKVAQSILHNLENTFGARVFDALMAEVLDSYLGNEMDALAVIKKRPDLFDRAFVEFLGEPGEKLLSTACKDVSAMLHLGRSVAYSKVGDLVKWMKAVVVASHNPRIMVIDDEQDILTVVETFLQDGGWEVDTFDNPLKALEYFKENNCSDCNDDDNYYSIVLIDVRMPAMSGLDLATELLKIRSDTKILLMTAFELEKEMQDRLPVTKHEDILKKPFQLEQVCTAIKKTMTLTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MT04</accession>
    <name>A0A075MT04_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SnoaL-like domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02179</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MT04"/>
    <dbReference type="STRING" id="1459636.NTE_02179"/>
    <dbReference type="KEGG" id="nev:NTE_02179"/>
    <dbReference type="eggNOG" id="arCOG10267">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1902037_0_0_2"/>
    <dbReference type="OrthoDB" id="8390at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13474">
        <property type="entry name" value="SnoaL_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="9"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="138" mass="16041" checksum="2627A01536870DD4" modified="2014-10-29" version="1">MSVTDSTKIRDLIYKYFQIAKSKEIEHIPAFFAERFTKFGDSPPYDLRDADRALMLEQLQFASISDYDFKINDLKIEIVAGEVAIATFALESTGIIVDDYSFRGTAINNKSRVTIMFQKDKKKEEWKMLHQHFSRMPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MT10</accession>
    <name>A0A075MT10_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydrofolate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MT10"/>
    <dbReference type="STRING" id="1459636.NTE_02189"/>
    <dbReference type="KEGG" id="nev:NTE_02189"/>
    <dbReference type="eggNOG" id="arCOG01490">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043966_3_0_2"/>
    <dbReference type="OrthoDB" id="7348at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="entry name" value="Dihydrofolate Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050765">
        <property type="entry name" value="Riboflavin_Biosynth_HTPR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38011:SF12">
        <property type="entry name" value="BIFUNCTIONAL DEAMINASE-REDUCTASE DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38011">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_8G06820)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="Dihydrofolate reductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bacterial bifunctional deaminase-reductase C-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="200" mass="22189" checksum="729064FF8B136706" modified="2014-10-29" version="1">MSMSMDGFIAGPNDDVERPLGDGGERLHEWLYDLASWRKLHGLAGGKTSRDAEILEESFNTSGAFVMGRRMFDLGERYWGDNPPFHMPVFVVTHNAQEKLVKQGGTTFAFVTDGIESALRQAQEAAGDKNVLVLGGANIIQQYLKAGLLDEIQVHLVPVLLGGGRRMFDNIDTGHIELERTRVIESPRVTHLGFRVVKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MT22</accession>
    <name>A0A075MT22_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01888</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MT22"/>
    <dbReference type="KEGG" id="nev:NTE_01888"/>
    <dbReference type="HOGENOM" id="CLU_3263609_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="41" mass="4849" checksum="19B16EF93AD04463" modified="2014-10-29" version="1">MAVSNNKPDWFWTDDGQLICRVKIGPIRRQQDHPQPHTIYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MT24</accession>
    <name>A0A075MT24_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02209</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700870.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MT24"/>
    <dbReference type="STRING" id="1459636.NTE_02209"/>
    <dbReference type="GeneID" id="41597930"/>
    <dbReference type="KEGG" id="nev:NTE_02209"/>
    <dbReference type="eggNOG" id="arCOG10519">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2550073_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="82" mass="9350" checksum="97AAB45D5A56F066" modified="2014-10-29" version="1">MSLSMNDKLTLLQYAINKYDSENTIKEKLNGILSTKDVERGIDTLIATQRVRRIGPDVIQNNVSHTELPELPDNLKEIVDRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MT49</accession>
    <name>A0A075MT49_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02239</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MT49"/>
    <dbReference type="STRING" id="1459636.NTE_02239"/>
    <dbReference type="KEGG" id="nev:NTE_02239"/>
    <dbReference type="HOGENOM" id="CLU_707137_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="390" mass="42658" checksum="BF560BB50C7C716F" modified="2014-10-29" version="1">MRHSLTAMALSAALVAFLVFAGMLQNVFAPIPLIEQLQGYLDPETKLYVGMGEIVNYSADSYPMGNVKLDLEFQGDNGRVHYSEPTVTNLLPVKGGFSIPPGMALPFVIVLNDTSLSSKVKSIEDVASQTGSGTWKPADLVVTPGQIHSISESEFDGVKYKTWAIEGTILNNYTQPTTHVYVVAGIHEGYRLVGVAGYSQKDKQPLTLGGMEKKNFTLYATMPANVNPDRVNFLAESDDSSMMRDNYLPILSKYSVNGVPVGSVDNVIIDNKTVTFTAELSNFARKDVDFDVVFQVLKVPFSGQYGNTINDDLLLQQSTTADLQVLHSSINALGTATVDYSWTADSGGYYAYAIYVVNDLDSPKMLSKPFMYKVSGYPPRFLASDMLHVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MT52</accession>
    <name>A0A075MT52_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00417</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699457.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MT52"/>
    <dbReference type="STRING" id="1459636.NTE_00417"/>
    <dbReference type="GeneID" id="41596296"/>
    <dbReference type="KEGG" id="nev:NTE_00417"/>
    <dbReference type="HOGENOM" id="CLU_1207653_0_0_2"/>
    <dbReference type="OrthoDB" id="376059at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="227" mass="25546" checksum="85009CD7A00B4C90" modified="2014-10-29" version="1">MLNKKASTIAVLVTSMLLIGILASVPPSNNAVAEEEKQDDNNNNDDGAIHTRVFITKPSCTDKSAWELQQSITLNKYGYYSYTNNSSLDVVCFPHVSLLTLDRTVEKARVAYPKDMLIFVYDLSSPRAASNNNSKNAQTSLVSDQWEWNLWLRLYSNIPSTFDYSLLLGKAWIDKGYAVADYNSEVINHEWAHLATCKIHGPNTDEGNPATWQPFFAQNETRPWCTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MT56</accession>
    <name>A0A075MT56_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01928</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700650.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MT56"/>
    <dbReference type="GeneID" id="41597676"/>
    <dbReference type="KEGG" id="nev:NTE_01928"/>
    <dbReference type="HOGENOM" id="CLU_041386_0_0_2"/>
    <dbReference type="OrthoDB" id="10595at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="507" mass="58042" checksum="2DFE314CF38DFC2F" modified="2014-10-29" version="1">MGHYLKNNNSWRGSAEKLLEFWEGLMCPTIADDLFGRNPLVQSSWDYLHAINPGIADAESARRFWSIFEFAFTPRGVPNMYESVPKWGSKFLNPFTDFLPWWQYDYKQLRSYLSKFVEFPIKTSLEKGQPRLLLTSVDVQDYATPVVLDSYEKQHDVSVNGKTVIAKAENGSSSSSSGRWYSEYGNSENTHIVFYDGIGPDQVLASALGKYALDHPEIEDKATGTVRQLWDGGYLSNTPLRELLTAHKNYWMEYLRKTRGSGSNRSITRTPELEVYIVNLHPLAPRDIPEDKDLIDDRESDILFHDRTTYDEQVAYVMTDFVDMAGELAELARSKGLSEKVEEILDRKAKTIARVDEYKFTTYRDLLYGKPRISKVWRIDRLESAGATFGKVTDFTPSTIRGLIRAGEIDARISIDRMEVVFAIEDLISDGIMSIEEGDEIIKEAREVLTTEQLLYRKRKEEVIEAYNRFVKIIEAKDIPLDRKEVMISPGRDIVAIVSKADNAKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MT57</accession>
    <name>A0A075MT57_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Class IIb bacteriocin, lactobin A/cerein 7B family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02689</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701250.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MT57"/>
    <dbReference type="STRING" id="1459636.NTE_02689"/>
    <dbReference type="GeneID" id="41598379"/>
    <dbReference type="KEGG" id="nev:NTE_02689"/>
    <dbReference type="HOGENOM" id="CLU_149773_0_0_2"/>
    <dbReference type="OrthoDB" id="384404at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023991">
        <property type="entry name" value="Bacteriocin_IIb_lactobn/cerein"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03949">
        <property type="entry name" value="bact_IIb_cerein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="148" mass="14620" checksum="B4E5BAF9EF70C158" modified="2014-10-29" version="1">MESVSKTNGGIAPSAIMAVIGGALMLAGGIFALSMLSLWNTQMMGMMMPSGLGGQMMMGGSGGWGMTMMVPDGAGFMWWAVGTLSAISVGAGAVSVAGGLAIHRKPASAGVWGIGILVASIVGLVSMSGFFIGPILGIIAGILALAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTC5</accession>
    <name>A0A075MTC5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00478</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTC5"/>
    <dbReference type="KEGG" id="nev:NTE_00478"/>
    <dbReference type="HOGENOM" id="CLU_2504796_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="85" mass="9667" checksum="B189949B4E3292E2" modified="2014-10-29" version="1">MLVLSRSISCSNDATTRLLFFMQARISLSLTTQYISYFVIIPTIFSKAIFGRICENFLRSWCTLNLGCHAANSRVICINYYILGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTR7</accession>
    <name>A0A075MTR7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Plastocyanin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_02489</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701095.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTR7"/>
    <dbReference type="STRING" id="1459636.NTE_02489"/>
    <dbReference type="GeneID" id="41598193"/>
    <dbReference type="KEGG" id="nev:NTE_02489"/>
    <dbReference type="eggNOG" id="arCOG02926">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1709035_0_0_2"/>
    <dbReference type="OrthoDB" id="11836at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000923">
        <property type="entry name" value="BlueCu_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052721">
        <property type="entry name" value="ET_Amicyanin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36507">
        <property type="entry name" value="BLL1555 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36507:SF1">
        <property type="entry name" value="BLL1555 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00127">
        <property type="entry name" value="Copper-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Blue (type 1) copper" evidence="3">
        <location>
            <begin position="68"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF84538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="163" mass="18051" checksum="73A9C875F6FD088E" modified="2014-10-29" version="1">MQVAKNHAGGIALTAFIAAVAVSLAYYQYVYVPEANRTPYVPPEIRNPEQTTHVTIVKDAGLESNPKHYDPMDVRAVLGLSNKVTWTNQDSTFHTVTTDDSENYVDAISGKFDSQAHLDETTNGFIAEGGSWSFTFTKEGDYHYHCVPHPFMQGVVHVVPNFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTT7</accession>
    <name>A0A075MTT7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative ABC-type transport system, periplasmic component/surface lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NTE_02122</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BMP lipoprotein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700799.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTT7"/>
    <dbReference type="STRING" id="1459636.NTE_02122"/>
    <dbReference type="GeneID" id="41597850"/>
    <dbReference type="KEGG" id="nev:NTE_02122"/>
    <dbReference type="eggNOG" id="arCOG00257">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038813_1_1_2"/>
    <dbReference type="OrthoDB" id="26049at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06304">
        <property type="entry name" value="PBP1_BmpA_Med_PnrA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050957">
        <property type="entry name" value="BMP_lipoprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003760">
        <property type="entry name" value="PnrA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34296:SF2">
        <property type="entry name" value="ABC TRANSPORTER GUANOSINE-BINDING PROTEIN NUPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34296">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN MED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02608">
        <property type="entry name" value="Bmp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter substrate-binding protein PnrA-like" evidence="8">
        <location>
            <begin position="46"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF84177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="355" mass="38024" checksum="DBE61700BB73FAF5" modified="2014-10-29" version="1">MPRSAKTYSAIIGIAAVAAVTAIVFVMPMIPALSQQSHLQQKSSLKVAVVTDALFSDMGWGESSLNAAKQIERKYGFDVAMQDNVEIPDIELTLKKYADAGYDLIIAHGVQWGEPALSVGKQYPNVKIVVFTGLVKSENVASIFPMQQEGSFLLGAIAGMMTKTNVIGYVGGEEYPNVINIFEGYKQGAKTVSPDIQVIGTYLNDWDNPAKGKEAATSIIRQKADFVFHVADTSGQGVIQAAKDGGVYALGAVQDQNSLAPNTVLSSFILDVDKAYDQAVDSVMKGTFKGEIHKAGIETGKGAPGDGIVYLAPFHGLKDKVPENVNARLKQLLADILEKRLAVPERLEESVSITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MU94</accession>
    <name>A0A075MU94_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03181</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701649.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MU94"/>
    <dbReference type="GeneID" id="41598839"/>
    <dbReference type="KEGG" id="nev:NTE_03181"/>
    <dbReference type="eggNOG" id="arCOG11428">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_157015_0_0_2"/>
    <dbReference type="OrthoDB" id="144619at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="131" mass="14153" checksum="DD1ED30643F12A34" modified="2014-10-29" version="1">MQGDLVFDEKGKVTGRRVLDATTMEVSFETKIKVKGVDGVNMGTYTSTMMPDGSMYGQGQGCVMSNDGQMVTWKGNGMGKLVQNGKIRFAGAIYLSTQSKGSLAPLNNVAVVFEHEGDMEGNVSSKGWEWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUH6</accession>
    <name>A0A075MUH6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02726</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701284.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUH6"/>
    <dbReference type="STRING" id="1459636.NTE_02726"/>
    <dbReference type="GeneID" id="41598416"/>
    <dbReference type="KEGG" id="nev:NTE_02726"/>
    <dbReference type="HOGENOM" id="CLU_1615359_0_0_2"/>
    <dbReference type="OrthoDB" id="9446at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="188" mass="21195" checksum="DF9B55FFF1A3B860" modified="2014-10-29" version="1">MNNMVSNRFINSFANGLTVSEATRQSLDEVKIKLKHGEWEIEITCLESKVKQVVETVLSSLDSAKIVDPAIRGQIDELRREIDALKSRSLVDVRPSVVSNDTKTIAKGGMTCRGLLETLWVEGYFASEKSLGDVHEELSRRGYNYDRTAVSHSLTDMVRENIMTRNGTMRNYRYIQKRPPSEVTATPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUJ4</accession>
    <name>A0A075MUJ4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein uS12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rps12</name>
        <name evidence="10" type="ORF">NTE_02746</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 9">With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 7 9">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701301.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUJ4"/>
    <dbReference type="STRING" id="1459636.NTE_02746"/>
    <dbReference type="GeneID" id="41598435"/>
    <dbReference type="KEGG" id="nev:NTE_02746"/>
    <dbReference type="eggNOG" id="arCOG04255">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115574_0_1_2"/>
    <dbReference type="OrthoDB" id="45154at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03367">
        <property type="entry name" value="Ribosomal_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000007">
        <property type="entry name" value="40S ribosomal protein S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00403_A">
        <property type="entry name" value="Ribosomal_uS12_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_uS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022863">
        <property type="entry name" value="Ribosomal_uS12_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005680">
        <property type="entry name" value="Ribosomal_uS12_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003254">
        <property type="entry name" value="PRK04211.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00982">
        <property type="entry name" value="uS12_E_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002133">
        <property type="entry name" value="Ribosomal_S12/S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7 9" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIF84788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="145" mass="16010" checksum="EF6C4EFD750B8B16" modified="2014-10-29" version="1">MGKSPLGLFAGGVLRTKKSRGRWADKYYKRRMLMLDKKANPLEGAPQARGIVLEKVGIESKQPNSAVRKCVRVQLIKNGKSVTAFLPRDGALNFVDEHDEVMVEGIGGSMGGAMGDIPGVRWQVFKVNGVSLKELVYGRKEKPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUJ9</accession>
    <name>A0A075MUJ9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fructose-1,6-bisphosphate aldolase/phosphatase</fullName>
            <ecNumber evidence="6">3.1.3.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">NTE_02857</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="3.1.3.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homooctamer; dimer of tetramers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FBP aldolase/phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.11" evidence="6"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701391.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUJ9"/>
    <dbReference type="STRING" id="1459636.NTE_02857"/>
    <dbReference type="GeneID" id="41598539"/>
    <dbReference type="KEGG" id="nev:NTE_02857"/>
    <dbReference type="eggNOG" id="arCOG04180">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041630_0_0_2"/>
    <dbReference type="OrthoDB" id="5829at2157"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042132">
        <property type="term" value="F:fructose 1,6-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002803">
        <property type="entry name" value="FBPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036076">
        <property type="entry name" value="FBPase_V_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041126">
        <property type="entry name" value="FBP_aldo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38341">
        <property type="entry name" value="FRUCTOSE-1,6-BISPHOSPHATE ALDOLASE/PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38341:SF1">
        <property type="entry name" value="FRUCTOSE-1,6-BISPHOSPHATE ALDOLASE_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01950">
        <property type="entry name" value="FBPase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015647">
        <property type="entry name" value="FBPtase_archl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111249">
        <property type="entry name" value="Sulfolobus fructose-1,6-bisphosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="10 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0704">Schiff base</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AIF84895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="374" mass="41290" checksum="A0EC74462D95E668" modified="2014-10-29" version="1">MRITISAIKADIGGIGGHTRPSDELVDAVKNFVAKNSKGMLIDHYIGYSGDDIHIIMTHTLGVDNEKIHKLAWDAFTEGTKVAKEQGLYGAGQDLLKDSFSGNVKGMGPGVAEIEMEERPSEVFCIFAADKTEPGAYNFPLWRMFVDARSNTGLLINERLAEGVVFRIMDVMSGKVADLKMWQDKAELEAALMYPGRYVVSAVFSADMSEQIVSASTDRLHNIAGTYVGKDDPIMIVRTQKNFPATEEAGSAFNDPHYVAGNTRGSHHMPLQPVKLNSPASLNYSIPIVSCLLFSMHNGKLTGPHDGFGTADWDLQRMWAAERAMIMRNQGFIHPATLIPEELEYNKGYQARMSKLESKFRDLDAQKKGKAGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUL9</accession>
    <name>A0A075MUL9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_02334</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700968.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUL9"/>
    <dbReference type="STRING" id="1459636.NTE_02334"/>
    <dbReference type="GeneID" id="41598050"/>
    <dbReference type="KEGG" id="nev:NTE_02334"/>
    <dbReference type="eggNOG" id="arCOG02358">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015921_0_0_2"/>
    <dbReference type="OrthoDB" id="342253at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00075">
        <property type="entry name" value="HATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43547:SF2">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43547">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="642"/>
            <end position="876"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF84387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="877" mass="98840" checksum="C800AACDD229A5B7" modified="2014-10-29" version="1">MEPDVKTEVFYGVENTIKAIRRFQSNAKKTWCVCADKTIPTLSASDKLRKGYLDGKARGVKIRYLTEITKENLERCKKVMEVAELRHLAGITGSFAVSESEYAGAFKQSLASEPFDVVVYSNMPELVEQQQNIFDIFWSNAIPAEQKIRELEENIPATKTEVLREAKDTTERVMHFFLNCRERMDACANSTAPSIAISVFKDAYENMKKRGVKTRWVTEITRDNLPYCKKLMEYAQVRHVDGFYGNFGVSETEYISATTVIEAQPVPALMYSNSKEMVEQQQYIFDSFWKKAIPAEQRIREIEEGILFPVETKVLKDLEDIRGRIIALHDNSGEVMVAANTGALHLVHNQFFGIYKKLMAKKANDKHKGIRWAMFIDKDSIDIVKTFLDIGMEIRHVKNMPSMYFAVSDKMYNATIETMDGGKMVQTLLTSTEPLYVQHFKSVFEELWKSGADARKRIQDIEAGINEETEVISSQYQTERVYKAIVNEASHEIMLILPTANAFARDKRIGIIGSLKEASSKKGTRVRVLVYAKEDANKQDIIDLESQGILVNDLSIKPAQKAIEEGAPRMTVVIIDNRTSLVIELKDDEKESFADAVGTSVFSTSRSIVLSYARIFESLWLETRLVAKLQESDRLQREFINIAAHELRTPVQPILAVIELLKGRFANGNAANVELTTTQLAIMDRNARRLQKLSSEILDATRIEAGTLRMDMEVMDINEKMKNMIADAKSWIPQGQSIDIQFKPLSDESGNPIPLLVKADKLRMFEVISNLIRNAIKFSAEGDVITIMTDRKDSDDDDGMAVVISVKDCGAGISAEVLPRLFTKFSADRERGGTGLGLFIAKNIVEAHGGRIWAENNNSSNDEKGATFAFTLPIHKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUR6</accession>
    <name>A0A075MUR6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Small ribosomal subunit protein uS10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rps10</name>
        <name evidence="7" type="ORF">NTE_02855</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the binding of tRNA to the ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_075054640.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUR6"/>
    <dbReference type="STRING" id="1459636.NTE_02855"/>
    <dbReference type="GeneID" id="41598537"/>
    <dbReference type="KEGG" id="nev:NTE_02855"/>
    <dbReference type="eggNOG" id="arCOG01758">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122625_0_1_2"/>
    <dbReference type="OrthoDB" id="371736at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.600:FF:000004">
        <property type="entry name" value="30S ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="entry name" value="Ribosomal protein S10 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_uS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_uS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_uS10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_uS10_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005729">
        <property type="entry name" value="Ribosomal_uS10_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01046">
        <property type="entry name" value="uS10_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00971">
        <property type="entry name" value="RIBOSOMALS10"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="Ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS10" evidence="6">
        <location>
            <begin position="6"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF84893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="103" mass="11588" checksum="A0698FBF4867B1B1" modified="2014-10-29" version="1">MPQAARIKLTSTNLTTLEGVCTEIKGIGEKSGIKLRGPHPLPTKRMKVVTRKSPCGQGTNTYDKYELRIHRRVIDVGADDRAIRQLMRLKIPDDVYIEVSLTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUW4</accession>
    <name>A0A075MUW4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701474.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUW4"/>
    <dbReference type="STRING" id="1459636.NTE_02965"/>
    <dbReference type="GeneID" id="41598636"/>
    <dbReference type="KEGG" id="nev:NTE_02965"/>
    <dbReference type="HOGENOM" id="CLU_2629852_0_0_2"/>
    <dbReference type="OrthoDB" id="377267at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="72" mass="7694" checksum="1E6BDC29A606D6F7" modified="2014-10-29" version="1">MTVKENLKLLAFMVGAALFFAVTLLGSFFGVIVFINSAGLPSDQALSFFMVGLVPPSVATFVLFTKGLGRFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUX9</accession>
    <name>A0A075MUX9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03438</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUX9"/>
    <dbReference type="KEGG" id="nev:NTE_03438"/>
    <dbReference type="HOGENOM" id="CLU_2802016_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="67" mass="7502" checksum="2780660AE9AF4D09" modified="2014-10-29" version="1">MFTCLSKSNKIAAFTALVIAMFSYYDVKTLRDLETRLTAKNKTAGLTAEIDALQKRVEELESKSINV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MV05</accession>
    <name>A0A075MV05_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nitrososphaera output domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02958</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701467.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MV05"/>
    <dbReference type="GeneID" id="41598629"/>
    <dbReference type="KEGG" id="nev:NTE_02958"/>
    <dbReference type="HOGENOM" id="CLU_1954560_0_0_2"/>
    <dbReference type="OrthoDB" id="380706at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041226">
        <property type="entry name" value="NitrOD2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18550">
        <property type="entry name" value="NitrOD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitrososphaera output" evidence="1">
        <location>
            <begin position="24"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="128" mass="14162" checksum="F7807B33D57B890C" modified="2014-10-29" version="1">MTMYGSYAYMLVPCHHDQMVLGVIIDSEKMADAILVKLQTIFGARVFDTLAATIVEDHLGGEMDMRTAMIQRPDLFESAFIEILGGIGEKILAKACYEVQTQFHVDEKVATVAAVTLPPIQKRETLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVD3</accession>
    <name>A0A075MVD3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02578</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVD3"/>
    <dbReference type="STRING" id="1459636.NTE_02578"/>
    <dbReference type="KEGG" id="nev:NTE_02578"/>
    <dbReference type="HOGENOM" id="CLU_2747969_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="70" mass="8103" checksum="865722B341DD6505" modified="2014-10-29" version="1">MHQKRCITCCIGAELQTSLKNIQLLNIFFSNYQVTLTIFPTLLFVIWYIYPPTTSLALVLGDFTIKRMDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVD4</accession>
    <name>A0A075MVD4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701578.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVD4"/>
    <dbReference type="STRING" id="1459636.NTE_03094"/>
    <dbReference type="GeneID" id="41598755"/>
    <dbReference type="KEGG" id="nev:NTE_03094"/>
    <dbReference type="eggNOG" id="arCOG04796">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017896_3_0_2"/>
    <dbReference type="OrthoDB" id="10617at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004377">
        <property type="term" value="F:GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038013">
        <property type="entry name" value="ALG11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45919">
        <property type="entry name" value="GDP-MAN:MAN(3)GLCNAC(2)-PP-DOL ALPHA-1,2-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45919:SF1">
        <property type="entry name" value="GDP-MAN:MAN(3)GLCNAC(2)-PP-DOL ALPHA-1,2-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="1">
        <location>
            <begin position="220"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="427" mass="47366" checksum="3205D704EEC8F190" modified="2014-10-29" version="1">MKKANVIHADLNPCGGAEQLAIATLQSLLEMEMQVELTVAKAPDLKRIEKAFGGKARRIFDHVNVKPLGRLPIELDWQTGTLTCRPSADSAILEYDMIVNTHGDILPYFLPSFSSKTCITYCHFPVVASYAACRNLDYLQSLVDLCLLDKDVMRMADSALFWRSFLEYYFLMLRNSIVVTNSKFSSQAIINAMTTGVHRMASEPTIIAPPVCVDELRQAALLSPSRADLVLVVSRIHPSKKLENAIELARILKQRGIGNKMIIAGNLVSDDSCSRRYHEQLAGMAEHYGLSDYVAIRPNVELGELWSLMQKSKAYFHPMPEEPFGISVVEAMAAGLVPIVPATGGLVEFVPQKYQFHSLEEAADMIQAALQASDKERLAISDSVKRFSMQAYTSRFSEFITERQLATATAPCERRMAPAAGRRSSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVK7</accession>
    <name>A0A075MVK7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Iron-regulated ABC transporter membrane component SufB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_02649</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron-sulfur cluster assembly SufBD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701218.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVK7"/>
    <dbReference type="STRING" id="1459636.NTE_02649"/>
    <dbReference type="GeneID" id="41598341"/>
    <dbReference type="KEGG" id="nev:NTE_02649"/>
    <dbReference type="eggNOG" id="arCOG01715">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026231_0_1_2"/>
    <dbReference type="OrthoDB" id="372168at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055346">
        <property type="entry name" value="Fe-S_cluster_assembly_SufBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010231">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000825">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037284">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045595">
        <property type="entry name" value="SufBD_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01980">
        <property type="entry name" value="sufB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30508">
        <property type="entry name" value="FES CLUSTER ASSEMBLY PROTEIN SUF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30508:SF1">
        <property type="entry name" value="UPF0051 PROTEIN ABCI8, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01458">
        <property type="entry name" value="SUFBD_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19295">
        <property type="entry name" value="SufBD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101960">
        <property type="entry name" value="Stabilizer of iron transporter SufD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUF system FeS cluster assembly SufBD N-terminal" evidence="3">
        <location>
            <begin position="134"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="SUF system FeS cluster assembly SufBD core" evidence="2">
        <location>
            <begin position="203"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00043967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF84692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="466" mass="51982" checksum="8EE4835169BD052C" modified="2014-10-29" version="1">MTAEDLNMDYSKYDFKDSTELYVYLSKKGLSRGTVEEISRMKGEPDWMRDFRLRSFDVFMSKPMPEWGGDLSKIDFQNIYYYAKASEKQGKSWDEVPESVRNTFEKLGIPEAERKFLAGVGAQYESEVVYHNLRDDLAKKGVIFADTDTAVKEYPEIVKKHFGKVIPPEDNKFAALNSAVWSGGSFIYVPPNVKVDLPLQAYFRINAENIGQFERTLIIADEGADVHYIEGCTAPVYSTESLHSAVVELIAKKGAKIRYTTIQNWSKDVYNLVTKRAYAYEGATVEWIDGNIGSKLTMKYPGVYMLGKGAHAEVVSIAFAGGGQHQDAGAKAVHLAPNTTSRITSKSVSKDSGRTTYRGLLHVAKGATGVKSNVRCDALLLDEKSRTDTYPYIEVNEDDATITHEATVGKIGEDQIFYLMSRGYTESDALSMIVGGFIEPFTKELPMEYAVELNRLVKLEMEGSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVQ6</accession>
    <name>A0A075MVQ6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Lsm C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_03306</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701758.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVQ6"/>
    <dbReference type="STRING" id="1459636.NTE_03306"/>
    <dbReference type="GeneID" id="41598958"/>
    <dbReference type="KEGG" id="nev:NTE_03306"/>
    <dbReference type="eggNOG" id="arCOG00999">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_145829_0_0_2"/>
    <dbReference type="OrthoDB" id="24895at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.60">
        <property type="entry name" value="Like-Sm ribonucleoprotein, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028277">
        <property type="entry name" value="Lsm_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037156">
        <property type="entry name" value="Lsm_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14894">
        <property type="entry name" value="Lsm_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sm" evidence="1">
        <location>
            <begin position="15"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="Lsm C-terminal" evidence="2">
        <location>
            <begin position="75"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF85335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="137" mass="15162" checksum="D8A8E4D3EAE52690" modified="2014-10-29" version="1">MAAVVTRKFGEETLQFIGKKVAVETSDSKVYNGTLAGVDDKLDIVLDNVEGHGILKMILNGAFVKEIRLMEKPFDFKALAERLERAFPGLVRIREDVGAIIVMDKIKVTQSGVEEGTGLSADRVRSIFDAFMKETKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVT8</accession>
    <name>A0A075MVT8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PepSY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701255.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVT8"/>
    <dbReference type="STRING" id="1459636.NTE_02695"/>
    <dbReference type="GeneID" id="41598384"/>
    <dbReference type="KEGG" id="nev:NTE_02695"/>
    <dbReference type="HOGENOM" id="CLU_1412305_0_0_2"/>
    <dbReference type="OrthoDB" id="12249at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="192" mass="20244" checksum="977C43F3A06DE070" modified="2014-10-29" version="1">MSSLKGNKKFLIPALLAAGLVASLVAATSFASAQNTTSPLGNNNTNNANNSTQKGAIPQANNNTNSTQAATMDKIVGTINIKEAEKTFLSDHLRVTLTDASRVAGSQGNGTAVTGRLGVVHDYLVYTITVANMNDGTVHKVIVDAGNGSVLYTSPAKPIDNSSLGRMMDGAFGHWTHEHHHHHHGHHDDDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVU7</accession>
    <name>A0A075MVU7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA repair helicase RAD25</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NTE_03346</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701791.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVU7"/>
    <dbReference type="STRING" id="1459636.NTE_03346"/>
    <dbReference type="GeneID" id="41598995"/>
    <dbReference type="KEGG" id="nev:NTE_03346"/>
    <dbReference type="eggNOG" id="arCOG00874">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008213_6_0_2"/>
    <dbReference type="OrthoDB" id="11644at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140097">
        <property type="term" value="F:catalytic activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17926">
        <property type="entry name" value="DEXHc_RE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050615">
        <property type="entry name" value="ATP-dep_DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040699">
        <property type="entry name" value="XPB_DRD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11274:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11274">
        <property type="entry name" value="RAD25/XP-B DNA REPAIR HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18458">
        <property type="entry name" value="XPB_DRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="100"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="354"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="458"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="78"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="464"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="504"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF85375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="523" mass="58171" checksum="ABCD68EF28E9EDC7" modified="2014-10-29" version="1">MLKAVLRYDRGTIVIEGLAHIPFATRDPRISALRAQAMYYPDIVEYLKQSGIEYDDRIFFSDNNNSMPLDSHYNNKDSSNNLSSSPSSPSLRDYQQRAFDNWVNAGMRGCVVLPTGSGKTLVGVKAIEKANAASLVVVPTLDLMDQWTAVLSKYFFASSSSATTTINRIGNLGGGSEDIQPITVSTYDSAYLRAAFLGNKFRLVVFDEVHHLAAPGYRTIAEQMVAPFRLGLTATIEREDSLHVDLPRLVGGVVYQVTPDVLARQKHLAQYEVERRRVELLPEELVQYKASMQKYHECLNRLLGGGGMTTDAAAARYTISLEKLIMMSGRNPLAREALLARNKAINIALNSKAKLEELKEILAENRGAKTIIFTQYNNMVYEISDRFLVPFITHKTGKDERQDVLKGFKDGRYMAIVTSKVLDEGVDVPDAELGVIVSGTGSAREFIQRLGRLLRPKPRAATAEAKDDGGSKEESKKARLIEIVSSETREETITSAKRKRALKRVQENHNDHDNTEVYGNSVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVV3</accession>
    <name>A0A075MVV3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription initiation factor IIB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NTE_02710</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TFIIB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701268.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVV3"/>
    <dbReference type="STRING" id="1459636.NTE_02710"/>
    <dbReference type="GeneID" id="41598400"/>
    <dbReference type="KEGG" id="nev:NTE_02710"/>
    <dbReference type="eggNOG" id="arCOG01981">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043736_0_1_2"/>
    <dbReference type="OrthoDB" id="7429at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023486">
        <property type="entry name" value="TFIIB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618:SF13">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00782">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Cyclin-like" evidence="7">
        <location>
            <begin position="137"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="7">
        <location>
            <begin position="231"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF84752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="319" mass="35109" checksum="F917D25C30EF6CF6" modified="2014-10-29" version="1">MPEDPSENPQSAASPEEEKEKKSSSLQNRHLVTDPETGELIDIKTGQVISESPLLSGEKEWRAFGTEKAGERARTGAPVSLARQDPDLSTIIGKTNRDAGGNVLDAGVRSRMARLRTWNARSQKSSPSERNLQRAFDMLARMKDRMALSDPVVEKVAYLYRKALKKKLIQGRTIDSVLAASIYIASRQMDMPRSLEDVSAKTGVSPKDIAGSYRTLVSKLDLRVPATDPVRYIAKVANNLGFSENIKRKALGILKEANSKNFIVGKDPTVIAASVLYVASRNTGEYRTQAEIANATGVTEATVRNRSKEPRKKLRSNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MW04</accession>
    <name>A0A075MW04_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Zinc-ribbon domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701753.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MW04"/>
    <dbReference type="STRING" id="1459636.NTE_03299"/>
    <dbReference type="GeneID" id="41598953"/>
    <dbReference type="KEGG" id="nev:NTE_03299"/>
    <dbReference type="eggNOG" id="arCOG08025">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2044520_0_0_2"/>
    <dbReference type="OrthoDB" id="6984at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038587">
        <property type="entry name" value="Ribosomal_eL40_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026870">
        <property type="entry name" value="Zinc_ribbon_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13240">
        <property type="entry name" value="Zn_Ribbon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zinc-ribbon" evidence="1">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="138" mass="15047" checksum="D645B82DAA4951F8" modified="2014-10-29" version="1">MTKVFNGRSATDEYMSTHSLTFSTPEMTLKKFALWLGEQVNAPGKGQVPRLMLYVEEKGEKSNSEFAPDTDDSFKPTGAVADMYGDVQAPAPTEQMTPPQLTPLNRETLEPEGKFCVSCGSRLKANAKFCNKCGSAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MW43</accession>
    <name>A0A075MW43_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">5'-deoxynucleotidase</fullName>
            <ecNumber evidence="5">3.1.3.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NTE_02807</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyribonucleoside 5'-phosphate + H2O = a 2'-deoxyribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:36167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18274"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:65317"/>
            <dbReference type="EC" id="3.1.3.89"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.89" evidence="5"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701353.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MW43"/>
    <dbReference type="STRING" id="1459636.NTE_02807"/>
    <dbReference type="GeneID" id="41598494"/>
    <dbReference type="KEGG" id="nev:NTE_02807"/>
    <dbReference type="eggNOG" id="arCOG04311">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039453_4_1_2"/>
    <dbReference type="OrthoDB" id="46088at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002953">
        <property type="term" value="F:5'-deoxynucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039356">
        <property type="entry name" value="YfbR/HDDC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11845">
        <property type="entry name" value="5'-DEOXYNUCLEOTIDASE HDDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11845:SF13">
        <property type="entry name" value="5'-DEOXYNUCLEOTIDASE HDDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13023">
        <property type="entry name" value="HD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD/PDEase" evidence="8">
        <location>
            <begin position="33"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF84847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="189" mass="21281" checksum="0D49B76035DECE5C" modified="2014-10-29" version="1">MVKDKDLTPFFDAVIGLKYVRRAGWAAKVGIKDPESVADHSFAMCAVGMALSDILGFDTRKVLKMIVLHDLAESAVGDYMPGEVSIIQKRQEEDGAMQKILACLPAKVRSDYAKIWREYLQDKTKEARFVHRIDKLEMALQAARYAKDGHPEELLAQFFDSAHKAVDIDDDILAEILKSLSPAQRMKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MW57</accession>
    <name>A0A075MW57_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385655.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MW57"/>
    <dbReference type="GeneID" id="43502678"/>
    <dbReference type="KEGG" id="nev:NTE_03350"/>
    <dbReference type="HOGENOM" id="CLU_3130670_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="49" mass="5689" checksum="EFCF350D51798B67" modified="2014-10-29" version="1">MEESNSHEDKEYALVSKSKLLALKSAIEDYVKEHNAIKKDLEKLRKIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MW84</accession>
    <name>A0A075MW84_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative xylanase/chitin deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_01486</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700299.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="STRING" id="1459636.NTE_01486"/>
    <dbReference type="GeneID" id="41597276"/>
    <dbReference type="KEGG" id="nev:NTE_01486"/>
    <dbReference type="eggNOG" id="arCOG02876">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG03561">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG03665">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG09729">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_254084_0_0_2"/>
    <dbReference type="OrthoDB" id="82199at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10917">
        <property type="entry name" value="CE4_NodB_like_6s_7s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059177">
        <property type="entry name" value="GH29D-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003410">
        <property type="entry name" value="HYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13290">
        <property type="entry name" value="CHB_HEX_C_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02494">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50825">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0858">Xylan degradation</keyword>
    <feature type="domain" description="NodB homology" evidence="4">
        <location>
            <begin position="29"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="3">
        <location>
            <begin position="478"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="513"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="513"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF83549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="1404" mass="148965" checksum="2A069553AA367798" modified="2014-10-29" version="1">MALFSVVLLIFNVVAIPNRSEAALAGSCNCVIFRIDDIQDYWINSVQVALMDQFINRNVNATFGIIMNFVGNDPLVVSKVREGHSSNLFELDLHGWNHVDYSQLSLQDQKNTLEMANQKLQDIWGRKSNIFIPPYNAYNVNTLNATSQLGLKIISSEFDQELPSIYDPDNPNSPNNKIYKAATGFDIKDQFGVYHLPQEVGFYTYDSEPPTKTPLSLIESRIDDAIASYGYVVITLHPQDFAVKNAQGVPSNAADQNELNDLNTLIDYAQGKQYKITTFSSVTKIPLPPIIDNVPPKVTPPADIALVTPDNPATVNSLGTATATDNIDLNPTITNNATSNLFPRGTTAVKWSATDDNNNVGTAIQYVTISPTNDAIRPAVKTTSPSAGAAISGPAAGVNILVTGTASDGQSGVKVVEVRTSTTAYQKATQTNGSSWANWYYILNIKTQGSTTVVSRATDFFANQQWDSTPISVSLAGPDITAPTITAPPSMTIEATGELTPVSLGKPFVFDNSDPSPNVTNDSPGASEATGFPLGTTTVTWTATDVSGNSASSNQAINVVDTTAPPAPQLLAPANGTVTNSPSTLSLDWSNETDIVSSSVTYDLLVDDNLDFSSPVVNQQGLTESSYAVSEALGDATYYWKVRSSDASSNKSPYSSVRSFIVDGLGPTVTASPPGGTYTVAQSVTLTASEPSSSTIYYTTDGSTPSTNSTVYTGPIAISSSTTLKFFARDTAGNNGATGTEVYVIDAAAPTVTATPQGGLYNSAQSVTLAASEPGFTIYYTTDGTTPNENSTVYAGPILISSNTDLKFFGKDGIGRTTPIVSETYTFDTTPPTVTASPPGGLYNTAQSVTLTASESSTIYYTTDGQTPTTFSPVYSSPIQISSNTDLKFFAKDTAGNEGLVVVETYVIDTVPPSVTASPPGGVYNASQSVTLTASKPGSTIYYTTDGSTPSTNSTVYSAPIPIIGQGTTTVLKFFAKDSIGNVGVVTTETYTISASSFPITHMSDTTATSGLSLYAGQQAHAEFVSPASQLVGKSIDQITLKLRKTNSPTGTAEVGVFNPDLTVKKLFGTKDAATLTSTYTDYTFSLSGLDLYTIQSGDRIGIKYAGGNSNNYMAVMLDRDAADPFDGTNTYRQQYTTSWLSFTSDDMYMILKQTHDATDTIAPTVTATPVGGTYTAAVSVTLAANEPATIYYTLDGSTPTTSSSVYTSPIQIASSTVLKFFGRDTAGNDSAPSTETYTINIPSFPVTQMSDTTATSGLSTYSAQQAHAEFVSPTSQLAGKSIDEITLKLRKTGTPTGTAEIGIFNPDLTVKKLFGTKDATTITTTYTDYTFSLSNGELYTLQSGDRIGIKYTSGSSTNFIAVMLDRDAADPFDGTNTYRQQYTTSWTSNTADDMYMILKQTHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWD0</accession>
    <name>A0A075MWD0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Adenylosuccinate lyase</fullName>
            <ecNumber evidence="8">4.3.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NTE_02931</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes two reactions in de novo purine nucleotide biosynthesis. Catalyzes the breakdown of 5-aminoimidazole- (N-succinylocarboxamide) ribotide (SAICAR or 2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate) to 5-aminoimidazole-4-carboxamide ribotide (AICAR or 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) and fumarate, and of adenylosuccinate (ADS or N(6)-(1,2-dicarboxyethyl)-AMP) to adenosine monophosphate (AMP) and fumarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarate</text>
            <dbReference type="Rhea" id="RHEA:23920"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:23921"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>N(6)-(1,2-dicarboxyethyl)-AMP = fumarate + AMP</text>
            <dbReference type="Rhea" id="RHEA:16853"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:16854"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.2" evidence="8"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWD0"/>
    <dbReference type="STRING" id="1459636.NTE_02931"/>
    <dbReference type="KEGG" id="nev:NTE_02931"/>
    <dbReference type="eggNOG" id="arCOG01747">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030949_0_1_2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00132"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00336"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070626">
        <property type="term" value="F:(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004018">
        <property type="term" value="F:N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01360">
        <property type="entry name" value="Adenylsuccinate_lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.200.10:FF:000014">
        <property type="entry name" value="3-carboxy-cis,cis-muconate cycloisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019468">
        <property type="entry name" value="AdenyloSucc_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004769">
        <property type="entry name" value="Pur_lyase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00928">
        <property type="entry name" value="purB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43172">
        <property type="entry name" value="ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43172:SF1">
        <property type="entry name" value="ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10397">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00145">
        <property type="entry name" value="ARGSUCLYASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00998">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Adenylosuccinate lyase C-terminal" evidence="9">
        <location>
            <begin position="390"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="NCBIfam" id="TIGR00928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIF84967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="481" mass="53160" checksum="81B578F35D50C155" modified="2014-10-29" version="1">MRWQVLMTCSHASSPGARFIFSAACPSFVPILPIDSGRYGSKEMRAIFSDEQRLQYQLDFEAAVAQVQARIKMVPEDAAKEIGRAAKSGKITLERVAELEAKSEHDTAAMVEAISEQVPASARPWVHYGLTSNDVVDTSTCMQMRDAFSIIEGKVAKLAQSLADRAVEFRDVPAVGRTHGQHASIISFGLKFAVWASEMARHIERIEEGKKRFLLCKTRGVVGTGSLMGDRALEVERLVAGDLGLWPVDAATQVIPRERYSEMQFLMALIGSTLDKMAIEIRNLQRTEIAEVAEPFKKGQMGSSAVPVKRNPIKSERVSSLARMLKSLVSVSMDNIPLWHERDLSNSANERFTLPMAAILLDEMLNATAKVVAELKVNKERVVANLDMTKGQIYAEFVLEALVKKGVARFDAYRDIQRVAFAAIESGEQFLDAVSKDESIGKHLSRKEIAAIFQAENHLAASGKIVDNVARLVKDITKKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWH3</accession>
    <name>A0A075MWH3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWH3"/>
    <dbReference type="KEGG" id="nev:NTE_03450"/>
    <dbReference type="HOGENOM" id="CLU_3379841_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="33" mass="3775" checksum="F20A6DB023415EFE" modified="2014-10-29" version="1">MELALEEYENEWFASQQNIDIDTVGAESTAVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWH4</accession>
    <name>A0A075MWH4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02967</name>
    </gene>
    <organism evidence="2 3">
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    <reference evidence="2 3" key="1">
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            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
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            <end position="135"/>
        </location>
    </feature>
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        <location>
            <begin position="97"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
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            <dbReference type="EMBL" id="AIF85002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="135" mass="14392" checksum="E92B4E5C7D0896C9" modified="2014-10-29" version="1">MAQQQLSESLWELKETAKWARDPVEKKTAIKNLSARGEEALPLLEEVLTVTAYDDIRSTCEEAIRSVREKNSSSSSQTAEKGKGSDISTGSSGSATEKSKADTKKEKEKEKDTASASTAAGKSKGSSGKLADLPP</sequence>
</entry>
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        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
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                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
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    </reference>
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            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
    <evidence type="ECO:0000313" key="2">
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        </source>
    </evidence>
    <sequence length="125" mass="12811" checksum="3D9E32DA81F68CE2" modified="2014-10-29" version="1">MDTTATNYYTALLAAAGVALALAAGTVQQSHAQYGVSGNPTAGATPDQLAECEKYNIDRIECNEQTILAARKWAITHENPNGSGTPMLSIGGNETLLYVGALGAIFGGVAAAFFVKGKKTTSATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWM2</accession>
    <name>A0A075MWM2_9ARCH</name>
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    <organism evidence="1 2">
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        <lineage>
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        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
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            <dbReference type="PubMed" id="24999826"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="GeneID" id="41598682"/>
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    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="175" mass="19243" checksum="EC31FE1766D22F83" modified="2014-10-29" version="1">MYARLCNIEILSSYVSEVSVGDLLTVQALVTNPLDWQHFYEKISTIKKGDRTDFMVVTQEGDRLQGMGDIVEVDRWSNRSKYGFKVKINVKKQKSLTDRRTRVPRKAQPVPLAKKKIEITTPAAASAPQQQEAAVAAAAAPYVIKAEDIAAFKDMLKGSLAMDMSASSSSSSSVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWN2</accession>
    <name>A0A075MWN2_9ARCH</name>
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        <submittedName>
            <fullName evidence="13">Kef-type K+ transport system, membrane component</fullName>
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        <name evidence="13" type="ORF">NTE_03505</name>
    </gene>
    <organism evidence="13 14">
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        <lineage>
            <taxon>Archaea</taxon>
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        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="AIF85533.1"/>
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    </dbReference>
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    <dbReference type="GeneID" id="41599127"/>
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    </dbReference>
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    <dbReference type="OrthoDB" id="12029at2157"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43562">
        <property type="entry name" value="NAPA-TYPE SODIUM/HYDROGEN ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43562:SF3">
        <property type="entry name" value="SODIUM ION_PROTON EXCHANGER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="9" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
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        <location>
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        </location>
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        <location>
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        </location>
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        </location>
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        </location>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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            <dbReference type="Pfam" id="PF00999"/>
        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
    <sequence length="420" mass="43913" checksum="4CB1EB31BAC164CB" modified="2014-10-29" version="1">MVAEGSAFIHVIITIGVLLFAAKIFAELFARFKLPIVLGELTAGIIVGPFALGAIPVFNGEPLVVLDETVKHIGEISAIVILFIAGLEITPREFLRGGAAAFTVGSLGVIVPFFVGFYVFEAYGLSALESMLIATALTATSIAITIQVLTELGRMRSKEARLILGAAIVDDILAIATLSVVTTMVQTGNTTPDIVEIALLIMKILGLFAALLIGAIFLIPKLLHTERLWKSKGSIEGVTTAAFFGAAGLAAFVGLSPIVGAFAVGMAVASTRVIHRMEEYVDKLQIIFAPLFFAIIGAQVDLRGANVNVLYLSAILVAVAIITKLVGTGLPSILFLKKDRSKAMRVGIGMISRGEVGLIVAGVGVSAGAITGDVYTSVIIMVAATTIITPLWLKAAYKKVPPEKAPSSAKTATKDDAPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWT7</accession>
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    </gene>
    <organism evidence="2 3">
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        <lineage>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
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                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85112.1"/>
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    </dbReference>
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    <dbReference type="OrthoDB" id="384797at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="396" mass="43286" checksum="7CD39C7A4C822F71" modified="2014-10-29" version="1">MSSTTRNSMTLALSILIVGVALAAYAFMPVSTFAADPGNGTITSPPVDAGGEQGDGGGDNDNDNPPVANNNDTSPTTPDQAPTSDPSIANNENQTAAATPDLSGAANNDTGDNDNATVAPSESDDTTAAPEGNNGTTATAPENNDDTVTAPNDSMTNNNPSENGTTATNSGENNTITTVPPENNGTTATTPENKDNNNNTTATSPLENNSDKGSGSNDDNKPQNSSNNGGNDDSKQDGSNHNKPERKLYDDSKDYQGPKYYKYKHHDNEGAQADDDDGRVGEHYSSHHKKFFKYKHDFTYYENVKIIIYHFYFKDFVGADFFVHFDYEHHDGNVLIFFDHPFKDHEYDDEGRFYFDEDGNEYQCDEYYQGSVYYEYKNAFYKCEDLTFSEDFEGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MXE4</accession>
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        <submittedName>
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        </submittedName>
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    <gene>
        <name evidence="1" type="ORF">NTE_03258</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="41598913"/>
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    <dbReference type="eggNOG" id="arCOG10546">
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    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="88" mass="10075" checksum="F73503F4374C7E56" modified="2014-10-29" version="1">MDDNACDSRTHTYRNGKTFEQCRQEARVVTGVLVGEIAQSGEVAWFRVLEAAGHDEIVYKLTLKYLREKGFDIGNFQAPQVKQQQQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MXS1</accession>
    <name>A0A075MXS1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="STRING" id="1459636.NTE_02037"/>
    <dbReference type="GeneID" id="41597778"/>
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    <dbReference type="HOGENOM" id="CLU_2911663_0_0_2"/>
    <dbReference type="OrthoDB" id="382568at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="3"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="67" mass="7874" checksum="413B665846B12051" modified="2014-10-29" version="1">MPSEDLERLKQILRQEISDIRRAIEDNQRQDFDELGGAFSRTADRNDLIRINTLRWVLDVIDTLDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MY06</accession>
    <name>A0A075MY06_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02109</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AIF84164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="KEGG" id="nev:NTE_02109"/>
    <dbReference type="HOGENOM" id="CLU_1648234_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="160" mass="18534" checksum="B576AF307E6382D6" modified="2014-10-29" version="1">MMRMNNEREQHFCALSRPKTAKWLKFEPATGKPVASKFAGGSYDALQHRPVSIKRPDSNYRRILAVLAEIRASGRAWLSGAEITTLYNQKYGTTKKTADIEKPLSRFYVWQWVDYRETKSRYALGLWSLKPDVNVQDIDDLFARAESHEQIFNGKKGYEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MZ51</accession>
    <name>A0A075MZ51_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Helix-turn-helix domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_02480</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701087.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MZ51"/>
    <dbReference type="GeneID" id="41598185"/>
    <dbReference type="KEGG" id="nev:NTE_02480"/>
    <dbReference type="HOGENOM" id="CLU_125301_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051081">
        <property type="entry name" value="HTH_MetalResp_TranReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33154">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR, ARSR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33154:SF33">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR SDPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12840">
        <property type="entry name" value="HTH_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF84529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="185" mass="20746" checksum="EC5812F63FE6940A" modified="2014-10-29" version="1">MKAVYVVRDPEVARVLVDPMRRAILSFLREKPMTQAQLADELGLSDASLNYHMKILKENGLVTLTKKVAEEHGIIQKFFSPAACLFVYDIDALPKDIARYFYPQSLERARSVISMHNLGIEAHDAHSVNAISDNLSRLLVSTAKAYVKKEVSYGNDELIHEIYGKAISALGKSTTNNSTPQRRKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N0F5</accession>
    <name>A0A075N0F5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 15">tRNA-splicing ligase RtcB</fullName>
            <ecNumber evidence="15">6.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">rtcB</name>
        <name evidence="17" type="ORF">NTE_02933</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential for tRNA splicing and maturation. Acts by directly joining spliced tRNA halves to mature-sized tRNAs. Joins RNA with 2',3'-cyclic-phosphate or 3'-phosphate ends to RNA with 5'-hydroxy ends.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP + H2O = a ribonucleotidyl-ribonucleotide-RNA + GMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:68080"/>
            <dbReference type="Rhea" id="RHEA-COMP:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:13936"/>
            <dbReference type="Rhea" id="RHEA-COMP:17355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:83064"/>
            <dbReference type="ChEBI" id="CHEBI:138284"/>
            <dbReference type="ChEBI" id="CHEBI:173118"/>
            <dbReference type="EC" id="6.5.1.8"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 3'-end 3'-phospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP = a ribonucleotidyl-ribonucleotide-RNA + GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:68076"/>
            <dbReference type="Rhea" id="RHEA-COMP:10463"/>
            <dbReference type="Rhea" id="RHEA-COMP:13936"/>
            <dbReference type="Rhea" id="RHEA-COMP:17355"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:83062"/>
            <dbReference type="ChEBI" id="CHEBI:138284"/>
            <dbReference type="ChEBI" id="CHEBI:173118"/>
            <dbReference type="EC" id="6.5.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14 15">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="14 15">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 15">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 15">Belongs to the RtcB family.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.-" evidence="15"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N0F5"/>
    <dbReference type="STRING" id="1459636.NTE_02933"/>
    <dbReference type="KEGG" id="nev:NTE_02933"/>
    <dbReference type="eggNOG" id="arCOG04246">
        <property type="taxonomic scope" value="Archaea"/>
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    <dbReference type="HOGENOM" id="CLU_022279_0_1_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003972">
        <property type="term" value="F:RNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0170057">
        <property type="term" value="F:RNA ligase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="tRNA-splicing ligase RtcB homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="tRNA-splicing ligase RtcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001233">
        <property type="entry name" value="RtcB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036025">
        <property type="entry name" value="RtcB-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11118">
        <property type="entry name" value="RNA-SPLICING LIGASE RTCB HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11118:SF1">
        <property type="entry name" value="RNA-SPLICING LIGASE RTCB HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01139">
        <property type="entry name" value="RtcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103365">
        <property type="entry name" value="Hypothetical protein PH1602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 14 15" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="180"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="active site" description="GMP-histidine intermediate" evidence="12">
        <location>
            <position position="413"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="210"/>
            <end position="214"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="337"/>
            <end position="338"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
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    <feature type="binding site" evidence="14">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
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    <feature type="binding site" evidence="13">
        <location>
            <begin position="387"/>
            <end position="390"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="394"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="413"/>
            <end position="416"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="489"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00033766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR601233-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU371113"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="490" mass="53014" checksum="59D86509B8C95206" modified="2014-10-29" version="1">MPEIATRTGLKVRKVSEKEFRIDPDSGRGMKVPVSIYANDSLIAKMVTDRTIDQAANVATLPGVRKHVVVLPDGHEGYGFPVGGVAATDVEDGVISPGGVGYDINCGVRLLRTSLTENDVRPRLKDLVNDLFKSIPSGVGSEGAVRLTKSELDELLVEGVGWAVRHGYGTSHDAEVCEESGTMKGADPGSVSDTARKRGAPQLGSLGSGNHFLELQKVDRIFDERAAKAMGIEKQGQLTVLVHCGSRGFGHQICTDYLRVSESALRKYNISLPDRELACVPNNSKEGESYRKAMFSALNFAWANRQMITHWTRKTFERFFGMSEDGLKMDLVYDVSHNIAKVERHRIDGEGTREVVVHRKGATRAFPSGMEQVPDKYRALGQPVIIPGSMGTASWILLGGKNSLDLSFGSTAHGAGRTMSRSAAKRSYTPEGVRGNLESKGIYLKALTKDGMVEETPEAYKDVDAVADVSDALGIATKVVRLVPIGVIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N0R5</accession>
    <name>A0A075N0R5_9ARCH</name>
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        <submittedName>
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        </submittedName>
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        <name evidence="1" type="ORF">NTE_03029</name>
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        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
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    <dbReference type="OrthoDB" id="6171at2157"/>
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    </dbReference>
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            <dbReference type="EMBL" id="AIF85064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="48" mass="5556" checksum="9CF5BCAD3735C7F5" modified="2014-10-29" version="1">MAKYDGIKGQELLDVEETKNEITLIFKDNRYLFVKIQNGQLVIDSVPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N1C9</accession>
    <name>A0A075N1C9_9ARCH</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
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        </source>
    </reference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="367" mass="39523" checksum="BA80BD923B4FF1E1" modified="2014-10-29" version="1">MYSPPQKAILNYGSQTTETSSSSSASEIKWSWACRILENGSSYGLDENVSNVAPKAGDLALVKVDRIGYHNSIITANNRKLRIYPGDLLVGVFGNRYATDALEGELFGVQDLSILTAGGMIGTVKSRHKEFGRPTSVTFVGFLKNKKGLKVNLKELGFHLSRPKGALKNIIIIVGTGMNAGKTTAARILVKSLSDQGLKVAACKLTGSVSNRDQDELRSAYARTIIDFSDYGFPSTYLCTKKELFDLFDTMVADLEKTNPDVVIMEIADGILQRETAILLAEQSVKGMIKGIILAADSAPAALYAAEKIEEMGHKVIAVSGAITSSPLFVKEFEENSRIPVYASVDTGKELADAVMKFIGDSSNSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N1X4</accession>
    <name>A0A075N1X4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03426</name>
    </gene>
    <organism evidence="1 2">
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N1X4"/>
    <dbReference type="STRING" id="1459636.NTE_03426"/>
    <dbReference type="KEGG" id="nev:NTE_03426"/>
    <dbReference type="HOGENOM" id="CLU_2490280_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="86" mass="9428" checksum="8CFCF4C0FDF9A078" modified="2014-10-29" version="1">MLSSTGWSFYARKTTSTGFITQQQYTVGSPCDSASNQMRLRISYDVSTQSWVVSFTHATGALNSKSFPAEARPYSQGLMGTTMEPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N2B3</accession>
    <name>A0A075N2B3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Riboflavin synthase</fullName>
            <ecNumber evidence="3 8">2.5.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NTE_03551</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the dismutation of two molecules of 6,7-dimethyl-8-ribityllumazine, resulting in the formation of riboflavin and 5-amino-6-(D-ribitylamino)uracil.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 2/2.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.9" evidence="3 8"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701949.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N2B3"/>
    <dbReference type="STRING" id="1459636.NTE_03551"/>
    <dbReference type="GeneID" id="41599168"/>
    <dbReference type="KEGG" id="nev:NTE_03551"/>
    <dbReference type="eggNOG" id="arCOG04713">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034388_0_1_2"/>
    <dbReference type="OrthoDB" id="10084at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004746">
        <property type="term" value="F:riboflavin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00402">
        <property type="entry name" value="Riboflavin_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.20:FF:000003">
        <property type="entry name" value="Riboflavin synthase, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.20:FF:000004">
        <property type="entry name" value="Riboflavin synthase, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001783">
        <property type="entry name" value="Lumazine-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026017">
        <property type="entry name" value="Lumazine-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006767">
        <property type="entry name" value="PRK09289.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009566">
        <property type="entry name" value="PRK13020.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00187">
        <property type="entry name" value="ribE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21098:SF0">
        <property type="entry name" value="RIBOFLAVIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21098">
        <property type="entry name" value="RIBOFLAVIN SYNTHASE ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00677">
        <property type="entry name" value="Lum_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000498">
        <property type="entry name" value="Riboflavin_syn_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51177">
        <property type="entry name" value="LUMAZINE_BIND"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Lumazine-binding" evidence="10">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="Lumazine-binding" evidence="9">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="Lumazine-binding" evidence="9">
        <location>
            <begin position="99"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Lumazine-binding" evidence="10">
        <location>
            <begin position="99"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="NCBIfam" id="TIGR00187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIF85579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="205" mass="22006" checksum="0C20FA00A16B4B4E" modified="2014-10-29" version="1">MFTGIVEGLAEVRSVARAKKGADTAIRVKLGRMARGLKVGDSVCINGACLTVTKLQKGEAQFEMVAETVRRTSLGGIKPGDKVNIERSMKVGDRLEGHFVLGHVDGTATIVEKIEKPSETTMWFKLGSKALASALVPKGSIAVDGISLTVVDVDKEKFSVSLIPHTLEMTSLGLKKKGDKVNIETDVLSKYVSKSNNNLGRRPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ML62</accession>
    <name>A0A075ML62_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HTH marR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_00082</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699220.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ML62"/>
    <dbReference type="STRING" id="1459636.NTE_00082"/>
    <dbReference type="GeneID" id="41596030"/>
    <dbReference type="KEGG" id="nev:NTE_00082"/>
    <dbReference type="eggNOG" id="arCOG08041">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1357861_0_0_2"/>
    <dbReference type="OrthoDB" id="11435at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF82166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="228" mass="25410" checksum="9453765A8B509A1A" modified="2014-10-29" version="1">MILDLPLNITIDLGIVILGVLFYAGGLVTVMALRRFREAAKRDDNSYHADDAVVEAVVLEYTRRLKDYDRVIAEMRTKLDIVEVKTQALVQQPHVMVQQQPSSPMSQQQAPHAQSVSEPVTVTQHPPAVTTTVAVEVEDGSGGQSNNGTIDYILKLLVERPRTSREVQHAIGRTREHTARLMKKLHESGLVSRDVNSKPFRYNITEAGRTRLTKERPSAAQAPKIQQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MM23</accession>
    <name>A0A075MM23_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Nascent polypeptide-associated complex protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">nac</name>
        <name evidence="7" type="ORF">NTE_00454</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Contacts the emerging nascent chain on the ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Interacts with the ribosome. Binds ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NAC-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_075054939.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MM23"/>
    <dbReference type="STRING" id="1459636.NTE_00454"/>
    <dbReference type="GeneID" id="41596330"/>
    <dbReference type="KEGG" id="nev:NTE_00454"/>
    <dbReference type="eggNOG" id="arCOG04061">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_146475_1_0_2"/>
    <dbReference type="OrthoDB" id="53273at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005854">
        <property type="term" value="C:nascent polypeptide-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14359">
        <property type="entry name" value="UBA_AeNAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.30">
        <property type="entry name" value="Nascent polypeptide-associated complex domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00814">
        <property type="entry name" value="NAC_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016641">
        <property type="entry name" value="EGD2/NACA0like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044034">
        <property type="entry name" value="NAC-like_UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038187">
        <property type="entry name" value="NAC_A/B_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005231">
        <property type="entry name" value="NAC_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002715">
        <property type="entry name" value="Nas_poly-pep-assoc_cplx_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00264">
        <property type="entry name" value="archaeal-type nascent polypeptide-associated complex protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21713">
        <property type="entry name" value="NASCENT POLYPEPTIDE ASSOCIATED COMPLEX ALPHA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01849">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19026">
        <property type="entry name" value="UBA_HYPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01407">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51151">
        <property type="entry name" value="NAC_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NAC-A/B" evidence="6">
        <location>
            <begin position="2"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="NCBIfam" id="TIGR00264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF82536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="111" mass="12811" checksum="33120A2C6C40A8EF" modified="2014-10-29" version="1">MMRGNREMRRMLDKMGLDMKEMPNVEEVIIKTDTKEFYLVKPQIIEMKGKDSTIFQVVATDIEEKQREVPTFKEDDILLVMQQANVSREKAVQALTESKGDMAQAILTLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMB9</accession>
    <name>A0A075MMB9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_00198</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_193354082.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMB9"/>
    <dbReference type="STRING" id="1459636.NTE_00198"/>
    <dbReference type="GeneID" id="59387784"/>
    <dbReference type="KEGG" id="nev:NTE_00198"/>
    <dbReference type="eggNOG" id="arCOG06947">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_184933_0_0_2"/>
    <dbReference type="OrthoDB" id="11760at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="8"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="36"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF82280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="100" mass="12147" checksum="B46C128F5F0A4E6C" modified="2014-10-29" version="1">MNFLHKSYKCDLCDSKLDTYDDLIKHAREVHHHAIVKCHECGKEFIHEKDRLHHAREEHEKKVRAREEKNLHRHDESKTKDMTPQEEVDVQTRKFSDNFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMJ3</accession>
    <name>A0A075MMJ3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00273</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699355.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMJ3"/>
    <dbReference type="STRING" id="1459636.NTE_00273"/>
    <dbReference type="GeneID" id="41596182"/>
    <dbReference type="KEGG" id="nev:NTE_00273"/>
    <dbReference type="HOGENOM" id="CLU_136580_0_0_2"/>
    <dbReference type="OrthoDB" id="11034at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="192" mass="20695" checksum="16BAC3BBEA2CEFD9" modified="2014-10-29" version="1">MKIGKAISIELRDGQRLSLSLKETRELYRKLGKMLTDASKGGRSARNVKAARKKKIRIAGKRSRATSTKPSSSSSKIISLSDAKRQEILAHLNREISATPRTLTNLLKGVSYSAGQLPAIRSIIESQQGVRAKTKGKRTLYLKKKTMTTTAAAAIGTTRRARVKTVPLDKEAKSAVVEAPAATSSSTTTTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMK5</accession>
    <name>A0A075MMK5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00288</name>
        <name evidence="2" type="ORF">NTE_01140</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMK5"/>
    <dbReference type="STRING" id="1459636.NTE_00288"/>
    <dbReference type="KEGG" id="nev:NTE_00288"/>
    <dbReference type="KEGG" id="nev:NTE_01140"/>
    <dbReference type="HOGENOM" id="CLU_2313647_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="99" mass="12215" checksum="F4ED45A09F4150C0" modified="2014-10-29" version="1">MNQSSFLAYFSFDLSIFREYFPFELILMFYLESIRDSFWYYSFDARRTLANVMYLAFQCSNYNTYQVYLSYWYIHSPTIIYNRPMYIPICSQEECFIMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MML5</accession>
    <name>A0A075MML5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00298</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MML5"/>
    <dbReference type="KEGG" id="nev:NTE_00298"/>
    <dbReference type="HOGENOM" id="CLU_2461615_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="88" mass="10630" checksum="5322F5917E993915" modified="2014-10-29" version="1">MEFTFHRNRIDKIPRQRMLDELEKVARQFNYIEFGKRDFARYSAIHSTTVIKEFGSWSKNVLTHFENGCKKRTLTLHLELNRLTGYIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMQ7</accession>
    <name>A0A075MMQ7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sugar kinase, ribokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_00636</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699631.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMQ7"/>
    <dbReference type="STRING" id="1459636.NTE_00636"/>
    <dbReference type="GeneID" id="41596499"/>
    <dbReference type="KEGG" id="nev:NTE_00636"/>
    <dbReference type="eggNOG" id="arCOG00014">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065902_2_1_2"/>
    <dbReference type="OrthoDB" id="26949at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584:SF166">
        <property type="entry name" value="RIBOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="4">
        <location>
            <begin position="15"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF82716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="300" mass="33288" checksum="F45DAD0808B0026D" modified="2014-10-29" version="1">MLTVFGTMALDTTRTPFRIEERILGGAATFASLSAGMFARTGMVAAIGEDMPLSHIEAVRSKGVDTKGIVTVSGGKCFHYDSEFDYNLSNRKTLKTELNVISDFDPVIPEEYATSEYVYLANNDPRQNMAILRHFEKPKLVVCDTIEYWIHTARDDVVKMIGKTDGVVINDSEARLLCNEVNIAKCARQIMSFGPKFAIIKKGEHGAVLFTKDGEVFPATAFFLDEISDPTGAGDSFAGGFLGHIARKDKVDFRTMKEAVIYGNVMGSFAVEDFGVRRLLAITKDDVEGRYQKYRNLVQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMS5</accession>
    <name>A0A075MMS5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00651</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMS5"/>
    <dbReference type="KEGG" id="nev:NTE_00651"/>
    <dbReference type="HOGENOM" id="CLU_2379253_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="94" mass="10520" checksum="46FC9BF618295229" modified="2014-10-29" version="1">MFYLFTCIYTHIVNLIYSYSQFQTLKSLAVAALTVILGVLLFSQLHFKNAEAKTLYSSDLGQTYAVFTMIAIAIAGFAIFLAIYTRESMAVKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MN92</accession>
    <name>A0A075MN92_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_00544</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699559.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MN92"/>
    <dbReference type="STRING" id="1459636.NTE_00544"/>
    <dbReference type="GeneID" id="41596414"/>
    <dbReference type="KEGG" id="nev:NTE_00544"/>
    <dbReference type="eggNOG" id="arCOG01580">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_170329_2_1_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription regulator AsnC/Lrp ligand binding" evidence="2">
        <location>
            <begin position="7"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF82625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="77" mass="8498" checksum="DB9040EF4F043659" modified="2014-10-29" version="1">MTLALCLIKCDYQSVKETLQSIRKVKGVLESHETSGPYDAILKVKADSQEELRSIVRNLGTISGVFAILTAIVYNVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNC2</accession>
    <name>A0A075MNC2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00574</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNC2"/>
    <dbReference type="KEGG" id="nev:NTE_00574"/>
    <dbReference type="HOGENOM" id="CLU_1840644_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="139" mass="15329" checksum="80CB7A3CB02891B2" modified="2014-10-29" version="1">MPGSKKHLHIDDGDMIATSVSKMLKTAKSGAITIDFADEPAVKVTANNGRIAVDLLQPTIFKVPEDETGLFDKLRTASEFASKLSDDGVTLSILRRGKEVIRLGKDSRPTFSRLITRSKDIQMSSMTEFARLKKDFKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MND1</accession>
    <name>A0A075MND1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00584</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699590.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MND1"/>
    <dbReference type="GeneID" id="41596448"/>
    <dbReference type="KEGG" id="nev:NTE_00584"/>
    <dbReference type="HOGENOM" id="CLU_812853_0_0_2"/>
    <dbReference type="OrthoDB" id="10392at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="342" mass="37792" checksum="DD8FB16BE20EF946" modified="2014-10-29" version="1">MTIGDANASDSTGNRIKRSLLLLLQSPSTRKRLIFVIIAAIVLTLALVLLAGIFQNLLPTVPPTADLLSPKDRFGITRLYPTSPGGIEWSSKWDNGNARTIGNEVDPADNWFETTHGDGTYVIDGKGTLTASGDVIRMYIHDPADEREWSENLEITLYVKRISETQIVDYSGLQVFARTNHGTNGNENVNYCDDRGYGGLVGINGRWAFEKESAHHLDDGYTRAAGQRPSGDLPKNTWVGFKYVLRNMDDNTKVKLELYRDTTGGANGGNWQKVTEFVDNGDNFGVGRGACRPEVDPSLPLIHSFINDSSETGKPMLSVYARHEYGTMAYSDFTIREINPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNP7</accession>
    <name>A0A075MNP7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative metal-binding integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNP7"/>
    <dbReference type="STRING" id="1459636.NTE_00755"/>
    <dbReference type="KEGG" id="nev:NTE_00755"/>
    <dbReference type="eggNOG" id="arCOG10678">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065506_0_0_2"/>
    <dbReference type="OrthoDB" id="11125at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018688">
        <property type="entry name" value="PpoB2-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09948">
        <property type="entry name" value="PpoB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="317" mass="34384" checksum="E95283432AE98EE7" modified="2014-10-29" version="1">MDKVQKIILVSLVSVSAASWLTSQTLQNDMMMTMTTAAMMPSPFASGMGDDNNGFGLASSYLFFVLLWTVGMAAMMFPAITPMVFLYNRLASSEKNNSQVQVALQKNDDASQKQVYPFKTLLFVGGYLAVWSLTGFVLLLGWSMLTSIMTSAASGLSIIQYIYGAILVIAGAYQFSPLKNKCLGYCESPLSFFMRRWSSGATGAAKMGVFHGLYCLGCCWPYFLLMVALGWMNLLWMALFSGIIFGEKVWSKKGIWIARAAGIGFVIIGILVMVTGGSAIIISMPTMMSTGDAAFTNTADMEPSANMTPAQKMPQMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNT2</accession>
    <name>A0A075MNT2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNT2"/>
    <dbReference type="STRING" id="1459636.NTE_00710"/>
    <dbReference type="KEGG" id="nev:NTE_00710"/>
    <dbReference type="HOGENOM" id="CLU_2985481_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="57" mass="6491" checksum="D28D06D7CAF3E6CB" modified="2014-10-29" version="1">MVHFITCTSSRPDNLQILITTTIGFAAFKFYEVRMANVYEVRAIPEQLITLKIKSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNW1</accession>
    <name>A0A075MNW1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699460.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNW1"/>
    <dbReference type="STRING" id="1459636.NTE_00420"/>
    <dbReference type="GeneID" id="41596299"/>
    <dbReference type="KEGG" id="nev:NTE_00420"/>
    <dbReference type="HOGENOM" id="CLU_2299436_0_0_2"/>
    <dbReference type="OrthoDB" id="8132at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="100" mass="10952" checksum="D406F271E1F93D59" modified="2014-10-29" version="1">MSEDTSPAASNEAIPFPTLTILYLPAEAAAVVEDVSQKYPNMTIEDCTGFFHGGQRIYKKVTIWSQGIDSLWMDAVIARTKELASVQFVNVVSGGMMHIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNW8</accession>
    <name>A0A075MNW8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Gins51 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699465.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNW8"/>
    <dbReference type="STRING" id="1459636.NTE_00425"/>
    <dbReference type="GeneID" id="41596304"/>
    <dbReference type="KEGG" id="nev:NTE_00425"/>
    <dbReference type="eggNOG" id="arCOG00551">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1399785_0_0_2"/>
    <dbReference type="OrthoDB" id="82417at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd11714">
        <property type="entry name" value="GINS_A_archaea"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21695">
        <property type="entry name" value="GINS_B_archaea_Gins51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054314">
        <property type="entry name" value="Gins51_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22090">
        <property type="entry name" value="Gins51_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gins51 C-terminal" evidence="1">
        <location>
            <begin position="138"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="189" mass="21281" checksum="A742CE81F3E2F5D1" modified="2014-10-29" version="1">MSENENDISLKYIYELLKKEIENPALQQIEPDTYQKVATSLGSLKGQGFEGVEAKVRDRMVELLSASARLLFEVRQRKVHEEGSEPLDYSRLTDEEKYVLDGEQEAAGRLDEVVAATTKGRPKVLEAISGRVREKRIVVRFVKAQEQFVGVDMTKYGPFQQEDVATLPLENARSFIEAGAAVQVHARLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MP15</accession>
    <name>A0A075MP15_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2H2-type zinc finger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_01194</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_193354090.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MP15"/>
    <dbReference type="STRING" id="1459636.NTE_01194"/>
    <dbReference type="GeneID" id="59387786"/>
    <dbReference type="KEGG" id="nev:NTE_01194"/>
    <dbReference type="eggNOG" id="arCOG08679">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3002959_0_0_2"/>
    <dbReference type="OrthoDB" id="7373at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13909">
        <property type="entry name" value="zf-H2C2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="16"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF83266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="56" mass="6303" checksum="B327E210F91153DE" modified="2014-10-29" version="1">MGLFGRGGKKQADGTFKCQYCDMKFDDKERMKRHMKKAHSEKGGGDMPNTNPFGFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MP57</accession>
    <name>A0A075MP57_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1802 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01246</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MP57"/>
    <dbReference type="STRING" id="1459636.NTE_01246"/>
    <dbReference type="KEGG" id="nev:NTE_01246"/>
    <dbReference type="eggNOG" id="arCOG09740">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085858_3_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014923">
        <property type="entry name" value="DUF1802"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008307">
        <property type="entry name" value="UCP018957"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08819">
        <property type="entry name" value="DUF1802"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018957">
        <property type="entry name" value="UCP018957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="181" mass="20633" checksum="8ACC7D1DCD5799E2" modified="2014-10-29" version="1">MQALKEWAVVCKALQEGRQTVLLRKGGILEFRQGFEVKHERFLLFPTYEHQAKEHLQQDYAGKLDAVLKEQPPAGANLLTGYAEAKLVKEISDTSVLKRLEKYHIWNESYVNARMAYNPKKPMSVILLRVYNLSSPISVNTKEEWAGCKSWIPVDLEATGRPSLDDAAFDRVSKEVTEVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MP60</accession>
    <name>A0A075MP60_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00501</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699529.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MP60"/>
    <dbReference type="STRING" id="1459636.NTE_00501"/>
    <dbReference type="GeneID" id="41596374"/>
    <dbReference type="KEGG" id="nev:NTE_00501"/>
    <dbReference type="HOGENOM" id="CLU_2216929_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="106" mass="11257" checksum="ECA4D127B52168B6" modified="2014-10-29" version="1">MKVRVNVNIDRLVIEGLEGGVTAAGLESSINAELARLIEHEYHVHQDSGQEEAGNAGASGLFKKKIARGGDFNVTDGGSFELSSRTSRSLGPDIARSIYSSIQKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MP99</accession>
    <name>A0A075MP99_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase-like domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MP99"/>
    <dbReference type="STRING" id="1459636.NTE_00536"/>
    <dbReference type="GeneID" id="41596408"/>
    <dbReference type="KEGG" id="nev:NTE_00536"/>
    <dbReference type="eggNOG" id="arCOG02708">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1860616_0_0_2"/>
    <dbReference type="OrthoDB" id="376004at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="6"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="137" mass="15856" checksum="6B2C596CAA737B63" modified="2014-10-29" version="1">MMMFKSLDFLYVPAPDIESSVKYYTQVLGGKLLWKIHAYGVWVACIELSKDEKRPYVLLADHIKKNDVMLIYQVENLENAARQLKSRGWKEESRVEIPPGPCCTFRDPADNALVIYENKRPYVMQEFRGKIDSAPPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPI4</accession>
    <name>A0A075MPI4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01399</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385187.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPI4"/>
    <dbReference type="STRING" id="1459636.NTE_01399"/>
    <dbReference type="GeneID" id="41597194"/>
    <dbReference type="KEGG" id="nev:NTE_01399"/>
    <dbReference type="HOGENOM" id="CLU_2550392_0_0_2"/>
    <dbReference type="OrthoDB" id="9705at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="82" mass="9020" checksum="203B7100F4D3AEF4" modified="2014-10-29" version="1">MQHIFKVTKSVGEATANLELYDGNSLALLESESFSDLYTLNFHLQTLATKYKTAGGLLIVHDKAKNSVELSLAKDENSLFVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPI8</accession>
    <name>A0A075MPI8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-type polysaccharide/polyol phosphate export systems, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NTE_01055</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699953.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPI8"/>
    <dbReference type="STRING" id="1459636.NTE_01055"/>
    <dbReference type="GeneID" id="41596877"/>
    <dbReference type="KEGG" id="nev:NTE_01055"/>
    <dbReference type="eggNOG" id="arCOG01467">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039483_6_0_2"/>
    <dbReference type="OrthoDB" id="147058at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047817">
        <property type="entry name" value="ABC2_TM_bact-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051784">
        <property type="entry name" value="Nod_factor_ABC_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43229">
        <property type="entry name" value="NODULATION PROTEIN J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43229:SF2">
        <property type="entry name" value="NODULATION PROTEIN J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00164">
        <property type="entry name" value="ABC2TRNSPORT"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-2" evidence="6">
        <location>
            <begin position="19"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF83128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="255" mass="27309" checksum="5497EE5B4896CE72" modified="2014-10-29" version="1">MNTVAVLLYRNLVASIDKVFLIWQVVFPIIYIFIAGYSYAGLLGGQGIAIGSTSVPYPAYLAAGMIGFNMMNSSTVAGSIIWNDKKNGMFKQILVMPFARMEYVLGNIVTIMLMGLASAGLILLAGSPTLLGSAQPTFVGSLYVLYALIVGAVFFGSIAIIISTRLKSSEGFNVIVNSVFLFFSFVSSAFYPSEGVPSELGTAFYINPLTYIVDITRAGVFNQITFFTNVEVGVIAAATAGTFLLATLSILRMKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPJ2</accession>
    <name>A0A075MPJ2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_01060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPJ2"/>
    <dbReference type="STRING" id="1459636.NTE_01060"/>
    <dbReference type="KEGG" id="nev:NTE_01060"/>
    <dbReference type="HOGENOM" id="CLU_2949437_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF83133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="63" mass="6749" checksum="E2555AE7CFD9B06E" modified="2014-10-29" version="1">MVGEAIANFDPYVGVAIGLFVVGLFAVMVYEKSSSSKSKHQQQQQHTAADVDAKRSSRSSSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPP4</accession>
    <name>A0A075MPP4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TRASH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_075055745.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPP4"/>
    <dbReference type="STRING" id="1459636.NTE_01105"/>
    <dbReference type="GeneID" id="41596920"/>
    <dbReference type="KEGG" id="nev:NTE_01105"/>
    <dbReference type="eggNOG" id="arCOG04508">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_185152_1_0_2"/>
    <dbReference type="OrthoDB" id="37898at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="entry name" value="Ribonucleotide Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011017">
        <property type="entry name" value="TRASH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007029">
        <property type="entry name" value="YHS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04945">
        <property type="entry name" value="YHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00746">
        <property type="entry name" value="TRASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRASH" evidence="1">
        <location>
            <begin position="4"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="46" mass="5251" checksum="4176DA435EF4B68E" modified="2014-10-29" version="1">MPVDPVCGIEMDQELAVSHEHNGKTYFFCCEGCKRIFVKKPGKYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPW3</accession>
    <name>A0A075MPW3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Secreted protein with C-terminal beta-propeller domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01543</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700347.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPW3"/>
    <dbReference type="STRING" id="1459636.NTE_01543"/>
    <dbReference type="GeneID" id="41597327"/>
    <dbReference type="KEGG" id="nev:NTE_01543"/>
    <dbReference type="eggNOG" id="arCOG02284">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015706_0_0_2"/>
    <dbReference type="OrthoDB" id="28968at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019198">
        <property type="entry name" value="Beta_propeller_containing"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09826">
        <property type="entry name" value="Beta_propel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="773" mass="84721" checksum="49E252F7316987CB" modified="2014-10-29" version="1">MARYSMYGMAGIGIAAAIGFVLILGSIGGNIAAKGPGSPAFMGGNGTTTGGGAPAVLTMASSQNIAKFSSLDELRAFLANVEAGRNAFSTALTGIPGSFEAYQVRLGVTDSDVRPTPPSTLEGGTTSAPSMSGKALTTNENSQNANVFSSTNNQVAGVDEPDFVKNDGKYAYVLSGDKLTISDVYPPENATIVSKIGLDIKGGQYLQEMILNNDTLVVFYTEYAQDYVIPQYEFAPQPISAPKTHALLLDVSDRANPKTVHDYVVSGSYDDARMIGDRVYLVTTSDLYSYRQPLVPKITESSRTVVAPDIYYFQNPEPYYNFNTVTSIDLANKDDDIIDSKTFMMNPSSTLYVSQDNIYIAYQKYLPYNYYEQSSRDRFFAAVVPLLPQDAQDKIKAVDSDVSIPASDKWDRIATILEDTYNGMGESEKKQLFEKIQKSLADYDSQAQKDATKTVIHRIAIGPNGEIDYKARGEVPGRLLNQFSMDESGNRFRVATTVEYYSPYAQGLYSNVYVLDKEDMQTVGKLEKIQPGETMYSTRFIGDRLYLVTFQRVDPFFVIDLSQDTPKVLGALKLPGYSTYLHPYDEDHVIGIGKDTKDNGYGGVVPTGVKLALFDVSDVANPKLAGEYTIPGQGTDSEVLFEHKALLFSKEKPNVLSIPVTKYDAENQYAPDGRYIPPKVWRGFYVFGTSPDSGIMLKGTVEHSSNVTDSYYYYGGAQVSRSFYIGNVLYTVSAGNLIKMNDINNNLADLGQLQIGSTGDVIKYPVPLDAQPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQ07</accession>
    <name>A0A075MQ07_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Kynurenine formamidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01186</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQ07"/>
    <dbReference type="STRING" id="1459636.NTE_01186"/>
    <dbReference type="KEGG" id="nev:NTE_01186"/>
    <dbReference type="eggNOG" id="arCOG02462">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030671_2_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31118">
        <property type="entry name" value="CYCLASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31118:SF12">
        <property type="entry name" value="CYCLASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="230" mass="25075" checksum="52FA7005E9CDADDD" modified="2014-10-29" version="1">MRERFFLLLINRGLRGNGIMMMKKVIDLTMSVSPAIKVFPGSLQPTFVGWSRFDVHGYDSEVMHMSTHTGTHMDAPSHFAPGKQAIDDISASRLVTQAVLVKVPKKADQLIEVSDISEEVRQGDTVVFATGWERQYKNSHYMTKNPGLSGKAAAYLVDKQVNAVAIDGPSIDAGFDVKFTAHNILLPSGVLAVENLCNLDKIKQKRFTLVVAPLKLAGASGSPVRALALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQB1</accession>
    <name>A0A075MQB1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Geranylgeranyl reductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_193354095.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQB1"/>
    <dbReference type="STRING" id="1459636.NTE_01655"/>
    <dbReference type="GeneID" id="41597430"/>
    <dbReference type="KEGG" id="nev:NTE_01655"/>
    <dbReference type="eggNOG" id="arCOG00570">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024648_0_1_2"/>
    <dbReference type="OrthoDB" id="46008at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011777">
        <property type="entry name" value="Geranylgeranyl_Rdtase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050407">
        <property type="entry name" value="Geranylgeranyl_reductase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02032">
        <property type="entry name" value="GG-red-SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42685:SF18">
        <property type="entry name" value="DIGERANYLGERANYLGLYCEROPHOSPHOLIPID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42685">
        <property type="entry name" value="GERANYLGERANYL DIPHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="1">
        <location>
            <begin position="4"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="386" mass="41249" checksum="80DAC30A569CDE45" modified="2014-10-29" version="1">MSHFDVIVAGGSISGLMAAREAAKACATVAVLEEDAEIGTPEHCGGLVSMEGMKNLGIVPDASAVENSRIRRARILSPSNGFELSAEKQKVVVLDRRALDKQVALQAQRASADIRVKCSVRSFNKDGTRYIVKTSEGDFTCDYFVDARGVASIINKNRDGVLSSAQYEVFAPWIKRDAIEVAFDSERYPGFFAWVIPTGDGRGKVGVAGKGINAASALKSYMDAKGPYSVVRKVYAPIWVMGPIASFVSGRTVVVGDAAGQTKPTTAGGIYTCGTGGLLAGRSIAKAIAAGKKDDSILDEYQKGWSAMFGEEFSKMLVARRLLERLDNKALDELFSAIPKDKLEDASSTGDFDFHTAALAKMLDVKSAGRMAKALLGNEIRRLVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQD3</accession>
    <name>A0A075MQD3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">50S ribosomal protein L37Ae</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NTE_01345</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL43 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700187.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQD3"/>
    <dbReference type="STRING" id="1459636.NTE_01345"/>
    <dbReference type="GeneID" id="41597143"/>
    <dbReference type="KEGG" id="nev:NTE_01345"/>
    <dbReference type="eggNOG" id="arCOG04208">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141199_2_1_2"/>
    <dbReference type="OrthoDB" id="372011at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_eL37/eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002674">
        <property type="entry name" value="Ribosomal_eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01780">
        <property type="entry name" value="Ribosomal_L37ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF83413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="77" mass="8572" checksum="9BD6FDDC50D67540" modified="2014-10-29" version="1">MARKKSSTALKGQGVKFGATVRKRYGKVYRTLHKKRRCPSCGSLRFGRIASGIWECPKCSFKIASGAYDIDLESLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQI8</accession>
    <name>A0A075MQI8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YokE-like PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_01735</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQI8"/>
    <dbReference type="STRING" id="1459636.NTE_01735"/>
    <dbReference type="KEGG" id="nev:NTE_01735"/>
    <dbReference type="eggNOG" id="arCOG01917">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084400_0_0_2"/>
    <dbReference type="OrthoDB" id="12348at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039519">
        <property type="entry name" value="YokE-like_PH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14470">
        <property type="entry name" value="bPH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YokE-like PH" evidence="2">
        <location>
            <begin position="14"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF83796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="268" mass="29950" checksum="4D64FE27632C07B2" modified="2014-10-29" version="1">MMLERMDPDIAGLLMPKEEILLVASQSKVAPGGSISAPDKIYITTSRVLFKDPKMFGLRANIIAIKYEEIATVMLKRGVFSTEILLKPLASLQHIDLPAVDKQVALQVSAFIQKGMRGELSSRKTAQKQEPKPEMRLEPEKPKMDALDRLERLALMKHQGMITEEEFAILKEELMLGIRPQISGEMLVVSSAVQPSRQLKAEPPKQAATIQEVAEPKKKKKKRNGCVPLLLLCSRAPCVQVLPRLRQGPQGRNQRLEDVPCVRCSDNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQR0</accession>
    <name>A0A075MQR0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQR0"/>
    <dbReference type="KEGG" id="nev:NTE_01485"/>
    <dbReference type="eggNOG" id="arCOG01055">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_159725_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038723">
        <property type="entry name" value="ArnR1-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14947">
        <property type="entry name" value="HTH_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ArnR1-like winged helix-turn-helix" evidence="1">
        <location>
            <begin position="2"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="85" mass="9620" checksum="E88F178C5A5EC66A" modified="2014-10-29" version="1">MDIAADVLEVAQGGAIKTRIMYKAFLSFPQLKEYLELLQDGGLLDYVAEEKEYHATERGKRFLKMYKEVGQAILPAGIRKKKTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQU2</accession>
    <name>A0A075MQU2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700230.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQU2"/>
    <dbReference type="STRING" id="1459636.NTE_01398"/>
    <dbReference type="GeneID" id="41597193"/>
    <dbReference type="KEGG" id="nev:NTE_01398"/>
    <dbReference type="eggNOG" id="arCOG08728">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_796008_0_0_2"/>
    <dbReference type="OrthoDB" id="9380at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047676">
        <property type="entry name" value="FxLYD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF038353">
        <property type="entry name" value="FxLYD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="353" mass="37679" checksum="3FB97AFB606950ED" modified="2014-10-29" version="1">MRLMAWAALATLLVLSTIAYPVVANANAASDDNNNTIELKNSNYSFVDAQGMTNVVGIVNNHGVAPISVTMALNVSDSSGRASTLHENLYGKVIYHGEGAPFKFRLGEGVKAVGKPYVADVKQVDQPFYDTLVLNYTNMAVGDERVLTGTMKNTGNTELRNVVVYASVHDENMTDLDSVRSNVVPLLRPGEQAVFTASPDPAVKAKVYYYSCAGFDINAPISTLPTGDGGFIAYDFASIAKVGSMRYDNATDSIAFDITHYNPKGGSASIKIPQLTQNQTVAVMMDGKPYDGATVKADGKTVYIDFFVPPGTHAVQIQGVRNMPEFPFAVLGLATLVAAVIAASRLKAAFKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRC4</accession>
    <name>A0A075MRC4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Methyltransferase domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_01298</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRC4"/>
    <dbReference type="STRING" id="1459636.NTE_01298"/>
    <dbReference type="KEGG" id="nev:NTE_01298"/>
    <dbReference type="eggNOG" id="arCOG01631">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1136086_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031151">
        <property type="term" value="F:histone H3K79 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025789">
        <property type="entry name" value="DOT1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026170">
        <property type="entry name" value="FAM173A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13610">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13610:SF11">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08123">
        <property type="entry name" value="DOT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DOT1" evidence="4">
        <location>
            <begin position="21"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF83367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="278" mass="31147" checksum="1CE55792E161DAED" modified="2014-10-29" version="1">MNIAEFMSTLPENVVRGESVELPEHALLQMFKLAGVKKNDTFFHLGCGQGEAVALAVKKFGVKKAVGVEIDEDAAAKARRKISHLRKNNNAEIVTGDIRDADISGASVVLFWFSDPAIVDAMVKKFRKELKDGARVITIWSPPGMMLPQKVDFPFFVCEKPFKYATSVRQQIKAVYGNKCIDFTAAWLLAERYIDALGVVPGQYRRFVNMLQSMVIWINAWNMGVTCEDGVPPPVNAYLGILREFFGIDMKDLFTRDPKDESMTMMKMPSDDDKMGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRG2</accession>
    <name>A0A075MRG2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Family 3 adenylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_01334</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRG2"/>
    <dbReference type="STRING" id="1459636.NTE_01334"/>
    <dbReference type="KEGG" id="nev:NTE_01334"/>
    <dbReference type="eggNOG" id="arCOG07810">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057456_1_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009190">
        <property type="term" value="P:cyclic nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050697">
        <property type="entry name" value="Adenylyl/Guanylyl_Cyclase_3/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43081:SF1">
        <property type="entry name" value="ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43081">
        <property type="entry name" value="ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="2">
        <location>
            <begin position="119"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF83402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="308" mass="34638" checksum="C9C5A6DDB6B7910D" modified="2014-10-29" version="1">MLVLTYNLNDFKSRELQYPKAGVAPEAKDDKKEAKKDKSEDNDNNNNSSASKNLVGMMMGGDSSSDKEKMAVVVDSETLVAQTQDRLWRALKRRYQYDSSLKPGQEYLLSHVSSKIPLVIMYADLVGSTNMSMTLPVDKLVTIIRAFTQEMSSVVESHKGYVLKYVGDAVIAFFPASYNRLSACDRAVQCARSMITVVKNGINPILNQYDYPELGVKIGMDVGENVIVQYGHDKSSPIDILGYCMNVAAKITSLTGSNRISIGQDVYDLLHPSEKTKFKEMKLGTEEWKYRDRVTDKVYRVYSLMENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRG3</accession>
    <name>A0A075MRG3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01682</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700459.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRG3"/>
    <dbReference type="STRING" id="1459636.NTE_01682"/>
    <dbReference type="GeneID" id="41597455"/>
    <dbReference type="KEGG" id="nev:NTE_01682"/>
    <dbReference type="eggNOG" id="arCOG10416">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_208209_0_0_2"/>
    <dbReference type="OrthoDB" id="8718at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="62" mass="7179" checksum="09FF4B1F37FE86D4" modified="2014-10-29" version="1">MVTVKTSTDEPKFKEVYCADCKMVLARYSIKYFTDTDINELVHVHYSAHIKEGHAIETRLAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRG6</accession>
    <name>A0A075MRG6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01617</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700407.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRG6"/>
    <dbReference type="STRING" id="1459636.NTE_01617"/>
    <dbReference type="GeneID" id="41597395"/>
    <dbReference type="KEGG" id="nev:NTE_01617"/>
    <dbReference type="HOGENOM" id="CLU_2949425_0_0_2"/>
    <dbReference type="OrthoDB" id="5659at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="72" mass="8113" checksum="BD91048BCDFD320A" modified="2014-10-29" version="1">MPKAQPSVFMLCETCRWCATYTDKSRAGDRCATCSGSLLSSFPIMPDEAFTFSYDEKRGVELDFFRRASPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRG9</accession>
    <name>A0A075MRG9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Roadblock/LAMTOR2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01687</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRG9"/>
    <dbReference type="STRING" id="1459636.NTE_01687"/>
    <dbReference type="KEGG" id="nev:NTE_01687"/>
    <dbReference type="eggNOG" id="arCOG08684">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_157016_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="145" mass="15984" checksum="B678F2BD5D0E4710" modified="2014-10-29" version="1">MPDAKRSVFAKKRALTFLIHQPVAVSVVKYDQLCAELAGLDNSIVATFVLSNKVTGMHVKMNVPKIKEEDTRLLAEQTATVMGITRTNERLFGKVGFLLVHHEFVDGIFFPAGNDTTVLVGLVQPYDQADVVEKVRKKIGSVFAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRU5</accession>
    <name>A0A075MRU5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dihydroorotase-like cyclic amidohydrolase</fullName>
            <ecNumber evidence="4">3.5.2.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_01478</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.2" evidence="4"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987217.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRU5"/>
    <dbReference type="STRING" id="1459636.NTE_01478"/>
    <dbReference type="GeneID" id="41597270"/>
    <dbReference type="KEGG" id="nev:NTE_01478"/>
    <dbReference type="eggNOG" id="arCOG00689">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015572_1_1_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004157">
        <property type="term" value="F:dihydropyrimidinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000174">
        <property type="entry name" value="Dihydropyrimidinase-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050378">
        <property type="entry name" value="Metallo-dep_Hydrolases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11647:SF1">
        <property type="entry name" value="COLLAPSIN RESPONSE MEDIATOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11647">
        <property type="entry name" value="HYDRANTOINASE/DIHYDROPYRIMIDINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="3">
        <location>
            <begin position="66"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF83542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="478" mass="52121" checksum="08015B21267A525F" modified="2014-10-29" version="1">MSASVTGHRAQGMENSCDILITNASAVIPKVGVVECDIAIEDGRIKTLKPSQNASASRRINAAGRYVLPGAIDPHVHYGVYTPIDEAALTESRSAAVGGVTTMMRMLRLYDTDYRAVEKQLQASKGAHYIDYAIHASILRKEQVKDIPYLKKKGINSLKIYMNLGADLNHIYMDLEPGEHGVKDGEVNMDDSLLSSIVEVGAKEHSTILVHAENPAVCAEHIRRGKEMGMSGLKAWSDCRPPQSEAESVAKISTLGRKFGANLYFVHIGSNAALDAILAERQKGNANYYIETCPQYLTHTYDFASVTGKVVPPIRSKSDVQSVWSALRNGIIDTVGTDHVANRLDIKMGNGDLWSALAGFPGIATMLPVLLDQGVNGDRISIERVAEVTSYNTARIFGMYPSKGTIQQGSDADLVMIDMDLEQKATPELLQSYSDYTIYDGWKLRGWPVLTMVRGKVVMEAGHVAQDALGHGQFVARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRV0</accession>
    <name>A0A075MRV0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative xylanase/chitin deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_01484</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700297.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRV0"/>
    <dbReference type="STRING" id="1459636.NTE_01484"/>
    <dbReference type="GeneID" id="41597274"/>
    <dbReference type="KEGG" id="nev:NTE_01484"/>
    <dbReference type="eggNOG" id="arCOG02876">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_958524_0_0_2"/>
    <dbReference type="OrthoDB" id="306789at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0858">Xylan degradation</keyword>
    <feature type="domain" description="NodB homology" evidence="2">
        <location>
            <begin position="28"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF83547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="336" mass="36747" checksum="AC43FDBBECC29559" modified="2014-10-29" version="1">MMTSILSLVVAGNIMLPTKAHAAPGACNCVIFRLDDIQDEWITHVQTAIIDKFIERNENLDLPIIMNSIGNDPVIVNKVKEGIATGLIETSLHGWNHIDYRTLSLQQQQKTLEMANQKMEELFGSKTSIFVAPYNAYNEDTLKAINQAGLKILSSEFDQEIESIYDPDNPDSPDNKVYKAIAGGSDTIIKDQFGVYHLPQVIGFYTYDSDPPTKTPLSKIESQIDSAIASYGYAVVTLHPQDFTVKDAGNNPTEELSQDEMKDLDTLLTWINDQNYHTGTFSGAVSNNNSQTSSAPATGSDDDNNDNNNDDAATVDLVAPLINTIISSLRPSLGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRW7</accession>
    <name>A0A075MRW7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01499</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRW7"/>
    <dbReference type="STRING" id="1459636.NTE_01499"/>
    <dbReference type="KEGG" id="nev:NTE_01499"/>
    <dbReference type="HOGENOM" id="CLU_194245_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="62" mass="7161" checksum="F58C35C4BCAD6DC0" modified="2014-10-29" version="1">MPILNSKHCPYIVTGTEMGYRVICERHNLKQFCNTIMEAKAVQSQHKREGCLESEIKKPGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MS02</accession>
    <name>A0A075MS02_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00102</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MS02"/>
    <dbReference type="STRING" id="1459636.NTE_00102"/>
    <dbReference type="KEGG" id="nev:NTE_00102"/>
    <dbReference type="HOGENOM" id="CLU_3210880_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="44" mass="5241" checksum="4C88900F047F494D" modified="2014-10-29" version="1">MSFASDHSHMCEHCSERFSCPIEKHECKMQWRTSHNDHYLALSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MS24</accession>
    <name>A0A075MS24_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01549</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700351.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MS24"/>
    <dbReference type="STRING" id="1459636.NTE_01549"/>
    <dbReference type="GeneID" id="41597331"/>
    <dbReference type="KEGG" id="nev:NTE_01549"/>
    <dbReference type="HOGENOM" id="CLU_2152693_0_0_2"/>
    <dbReference type="OrthoDB" id="9489at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="114" mass="13241" checksum="79E5B353F9CE0FB2" modified="2014-10-29" version="1">MITAFQLRLEELKRAGNSREDRMNLYRRYFASSRYNRLLIQQVLIRSAGNPALAKEVAAMEKEHNSDYAKTVERVKKWGYYEEFLAAVKEEDDALTRIIEAYDKRMKTAEGGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MS33</accession>
    <name>A0A075MS33_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02272</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MS33"/>
    <dbReference type="STRING" id="1459636.NTE_02272"/>
    <dbReference type="KEGG" id="nev:NTE_02272"/>
    <dbReference type="HOGENOM" id="CLU_1665407_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="158" mass="17948" checksum="949E7D6C7D985D3A" modified="2014-10-29" version="1">MVAAKTFFARMNEGRSQWLTEAQMLKACEEFFGHNGYNDLDRDVMFAGHQNFVSPLIGSSELETIATIFRPRLDKYDMGFFGMLEGTLYDVIDNHDKATLMLATDSLSYDPITKIEEIGVAIENLMDEGMYLLFVNGRLAHALFDDFKKLTMPVPVQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MS90</accession>
    <name>A0A075MS90_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">L-threonylcarbamoyladenylate synthase</fullName>
            <ecNumber evidence="3">2.7.7.87</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">L-threonylcarbamoyladenylate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">NTE_02379</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonine + hydrogencarbonate + ATP = L-threonylcarbamoyladenylate + diphosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:36407"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="EC" id="2.7.7.87"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SUA5 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.87" evidence="3"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701008.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MS90"/>
    <dbReference type="STRING" id="1459636.NTE_02379"/>
    <dbReference type="GeneID" id="41598094"/>
    <dbReference type="KEGG" id="nev:NTE_02379"/>
    <dbReference type="eggNOG" id="arCOG01952">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031397_3_1_2"/>
    <dbReference type="OrthoDB" id="39992at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061710">
        <property type="term" value="F:L-threonylcarbamoyladenylate synthase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.10">
        <property type="entry name" value="DHBP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="Sua5-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050156">
        <property type="entry name" value="TC-AMP_synthase_SUA5"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00057">
        <property type="entry name" value="L-threonylcarbamoyladenylate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17490">
        <property type="entry name" value="SUA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17490:SF16">
        <property type="entry name" value="THREONYLCARBAMOYL-AMP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="YrdC/RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="YrdC-like" evidence="12">
        <location>
            <begin position="8"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIF84431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="202" mass="21339" checksum="5E6BDFC27F1D8A77" modified="2014-10-29" version="1">MTEILDCPEGVVRCASIVKEGGVVVFPTDTVYGIGCDPYSDSSVARIFEIKGRQEDKPLPVLAASMKDAEKIVKLGKAGRALAKKFWPGALTIVAPLADPKISDRVLAGRQSLAVRVPANKCLLNLLSICKYIVGTSANPSGRPSPRSAQEVAIEGYDALLVDKAALIGLESTIVDVTGIPRIIRQGAISAGEIEKVLGENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSB4</accession>
    <name>A0A075MSB4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_01990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSB4"/>
    <dbReference type="KEGG" id="nev:NTE_01990"/>
    <dbReference type="HOGENOM" id="CLU_856869_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF84048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="324" mass="35351" checksum="2A4AA835054B2901" modified="2014-10-29" version="1">MRQHASRLSKRLVFTATKAVALLAVLTAAVLSPFVYQSGTDSAMAIGAEDNDGMVLDQQAASGKTHFLNHPSPDAPDGYSLLTLNTMDTNGTSIRIGNVTVADISEKSSENSEPQNRNSDTVDNESSVLSNNNSNNNHPLTPKTFLLKDNHRYDITVPDHWIYNGTYYMFDHWLGIGKNDEVIDDDAKGNGSGSTTTLNTLAGSNNTTLTAVYQAVPITGEHFSDKIYHQFLTNNTVITLSEGEYCCVPNGPVQIEKIYPDHVALKVFGFNIVRIITENATLHVGENITAGCGDSWVNLRLLKINDNDNTATFYKIYTVTGCPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSB7</accession>
    <name>A0A075MSB7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Kef-type K+ transport system, membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NTE_02421</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSB7"/>
    <dbReference type="STRING" id="1459636.NTE_02421"/>
    <dbReference type="KEGG" id="nev:NTE_02421"/>
    <dbReference type="eggNOG" id="arCOG01953">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005126_7_1_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43562">
        <property type="entry name" value="NAPA-TYPE SODIUM/HYDROGEN ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43562:SF3">
        <property type="entry name" value="SODIUM ION_PROTON EXCHANGER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0050">Antiport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="9" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="228"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="299"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="11">
        <location>
            <begin position="9"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIF84471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="402" mass="42134" checksum="2F29CA6C7277701F" modified="2014-10-29" version="1">MISLGILLFAAKIFAELFARIKLPVVLGELVAGIIVGPFALGGLVMFQDKPIVNLDETVRTIGEMSAVVILFIAGLEITPREFLRGGASAFTVGAIGVAVPFFLGYFVFLQFGLAALESMLIATALTATSIAISVQVLTELGRIRAKEARLIIGAAIVDDILAIAVLSVVTTMVQTGNVTPAITDIVFLILKILGIFAALLVGAIFLIPRLLHVERLWKSRGSIEGIATAAFFAAAGIAAFVGLSPIVGAFAVGMAIASTRVIHRIEEYVDKLQIIFAPLFFAIIGAQVDLRGVNADVLLIAGALIAVAIGSKMVGCGLPALLFLKDRNKSMKVGIGMISRGEVGLIVAGVGVSSGALTGNIYTAIIIMVAATTIITPIWLKSAYRKDPPEPAAPEQQKTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSB8</accession>
    <name>A0A075MSB8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytidyltransferase-related enzyme</fullName>
            <ecNumber evidence="4">2.7.7.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_01636</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.2" evidence="4"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700421.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSB8"/>
    <dbReference type="STRING" id="1459636.NTE_01636"/>
    <dbReference type="GeneID" id="41597412"/>
    <dbReference type="KEGG" id="nev:NTE_01636"/>
    <dbReference type="eggNOG" id="arCOG01222">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG03924">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034585_2_1_2"/>
    <dbReference type="OrthoDB" id="1912at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003919">
        <property type="term" value="F:FMN adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050385">
        <property type="entry name" value="Archaeal_FAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43793">
        <property type="entry name" value="FAD SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43793:SF1">
        <property type="entry name" value="FAD SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="3">
        <location>
            <begin position="72"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF83697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="209" mass="23260" checksum="3765B0A0F73283E0" modified="2014-10-29" version="1">MEPEDKSILAAIYASTLDPSVQAYDRLRAKLPVGKKFFEERIKRLAEIGMVEKNSSPPKLTFIGRDALKVVLVGGVFDLIHPGHIHTLKAAKEVGDVLVVVIARTATALKIKKDRKIYHDENLRKELVESLNFVDLALIGREGTLYDTVEFVRPDVIALGYDQAHSEKDVAENCKKRNLNVQVIRLSTPIPGSKSSKIKEELGDTIYGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSH6</accession>
    <name>A0A075MSH6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00217</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSH6"/>
    <dbReference type="KEGG" id="nev:NTE_00217"/>
    <dbReference type="HOGENOM" id="CLU_3371264_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="34" mass="3861" checksum="F4FB0B48CD53296E" modified="2014-10-29" version="1">MEWTLVSVLWVQAEDKAKELEVQGKVKGEEDKGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSH9</accession>
    <name>A0A075MSH9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01686</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700462.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSH9"/>
    <dbReference type="STRING" id="1459636.NTE_01686"/>
    <dbReference type="GeneID" id="41597458"/>
    <dbReference type="KEGG" id="nev:NTE_01686"/>
    <dbReference type="HOGENOM" id="CLU_196478_0_0_2"/>
    <dbReference type="OrthoDB" id="374531at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="77" mass="8921" checksum="28A9D9C94BB40DB3" modified="2014-10-29" version="1">MSQQFREYEQKVRKASFVLCPSCYWCATYFATVDDKFPECPVCRSVVIDSIPISESEFYHVNITGNGNVELRFRRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSL9</accession>
    <name>A0A075MSL9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Methionine adenosyltransferase</fullName>
            <ecNumber evidence="5 13">2.5.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">NTE_01726</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">SR1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the AdoMet synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="5 13"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700492.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSL9"/>
    <dbReference type="STRING" id="1459636.NTE_01726"/>
    <dbReference type="GeneID" id="41597495"/>
    <dbReference type="KEGG" id="nev:NTE_01726"/>
    <dbReference type="eggNOG" id="arCOG07444">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041802_1_1_2"/>
    <dbReference type="OrthoDB" id="6056at2157"/>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18079">
        <property type="entry name" value="S-AdoMet_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000003">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000004">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00086">
        <property type="entry name" value="S_AdoMet_synth1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022631">
        <property type="entry name" value="ADOMET_SYNTHASE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022630">
        <property type="entry name" value="S-AdoMet_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022629">
        <property type="entry name" value="S-AdoMet_synt_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022628">
        <property type="entry name" value="S-AdoMet_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002133">
        <property type="entry name" value="S-AdoMet_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022636">
        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01034">
        <property type="entry name" value="metK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11964">
        <property type="entry name" value="S-ADENOSYLMETHIONINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02773">
        <property type="entry name" value="S-AdoMet_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02772">
        <property type="entry name" value="S-AdoMet_synt_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00438">
        <property type="entry name" value="S-AdoMet_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000497">
        <property type="entry name" value="MAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55973">
        <property type="entry name" value="S-adenosylmethionine synthetase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00376">
        <property type="entry name" value="ADOMET_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00377">
        <property type="entry name" value="ADOMET_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="12" id="KW-0630">Potassium</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S-adenosylmethionine synthetase N-terminal" evidence="14">
        <location>
            <begin position="5"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine synthetase central" evidence="15">
        <location>
            <begin position="115"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine synthetase C-terminal" evidence="16">
        <location>
            <begin position="233"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="NCBIfam" id="TIGR01034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AIF83787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="380" mass="41447" checksum="A1D6E2BAD395917A" modified="2014-10-29" version="1">MVKRWLFTSESVTEGHPDKVCDQISDALLDEFLRQDPDSRVAAESMTTTGIVFVAGEVTSKGRVDVQKIVRDTIREIGYDKPDYGFDCDSCSVLAALHEQSPDISMGVTATEKKEQGAGDQGLMFGYATNETPQLMPLPITMAHQLSMKLSQSRKSKELGWLRPDGKSQVSVVYEEGIPKRIDTVVISTQHAPDISMDQLREEVIGKIIKPVCGEWVDSKTKYLVNPTGRFVIGGPPGDTGLTGRKIIADTYGGMGRHGGGAFSGKDPSKVDRSACYMARYVAKNVVAAGLADKCEVQVAYAIGVAEPVSVMVDTFGTGKAPEEEIEARVRKVFDMKPAGIIKTLDLKRPVYRKTAAYGHFGRSEPGFTWEKTDKASLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSP1</accession>
    <name>A0A075MSP1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cytotoxic translational repressor of toxin-antitoxin stability system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00287</name>
        <name evidence="2" type="ORF">NTE_01141</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699367.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSP1"/>
    <dbReference type="STRING" id="1459636.NTE_00287"/>
    <dbReference type="GeneID" id="41596954"/>
    <dbReference type="KEGG" id="nev:NTE_00287"/>
    <dbReference type="KEGG" id="nev:NTE_01141"/>
    <dbReference type="HOGENOM" id="CLU_155761_1_3_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="entry name" value="RelE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031552">
        <property type="entry name" value="ParE-like_toxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35601">
        <property type="entry name" value="TOXIN RELE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35601:SF1">
        <property type="entry name" value="TOXIN RELE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15781">
        <property type="entry name" value="ParE-like_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143011">
        <property type="entry name" value="RelE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="104" mass="12254" checksum="2680D691CA40AA67" modified="2014-10-29" version="1">MREVFFGRRKVEKEFSKLDSYTQKRVAKAIEEIRENPQVGILLTGDLAGYFKYKFGKFRAVYSYDEEKIMIVALDTRDDVYDEIKRYIREVGKIQVSAKKAVDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSQ7</accession>
    <name>A0A075MSQ7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00302</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSQ7"/>
    <dbReference type="KEGG" id="nev:NTE_00302"/>
    <dbReference type="HOGENOM" id="CLU_533833_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="585" mass="64716" checksum="5E80CCF40564945D" modified="2014-10-29" version="1">MLDNNNNNNNNNHKAQKHSPDLEILKQQYLLALQPPSMSKIQKDLQASAVEIDGSRRYLAATGGGAMASQILPEPAHYIPIDSTGVGCFPWYWQLPDGFNKLTYDYLDNVVRTTEQGLLALSPSFSTRYLDLLNTIDYVWSTKEVKELEGLIGEIHSLEQEIVSKYEDDGDNNSNNSGGGFGEIIYEAELEEAAKEMRLPVMTKIAYVLNYKLGYVWSGRRSQKLAPMNSKDLYETTDLSPLFLQAPPRALDIFSKPLANLFQLYRKWASTLGCLCEKSSLVQLALQNNCRPKLGNGGIVIVHPDGNKSISVGYRVLQPVNQVAKSLNDPANTLEMQISVEELNAEGGEVKVSVNKKPPLIVPGPIMQLEFREHNRIYHTFSFDGTCSQAIIKKTFFGPTVIDVQPFVFKPESQSGWLYLEPIRKAVENLKAGDDDDNDNDNDKEGYRFVLPPACDFNPGGDFGLIGSLFVCREITIEIMYPQGDLKSLSSSFPTDAAAALNVNLFGDIRIGSRGRRPLVARLSKDEQTGAPTIILALAPETVPVPLAEQLAYVIGGRVFYPGAFSAARCRKSMQDQMSPSSSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSV4</accession>
    <name>A0A075MSV4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Theronine dehydrogenase-like Zn-dependent dehydrogenase</fullName>
            <ecNumber evidence="6">1.1.1.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NTE_02181</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.14" evidence="6"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700848.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSV4"/>
    <dbReference type="STRING" id="1459636.NTE_02181"/>
    <dbReference type="GeneID" id="41597905"/>
    <dbReference type="KEGG" id="nev:NTE_02181"/>
    <dbReference type="eggNOG" id="arCOG01459">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_0_2"/>
    <dbReference type="OrthoDB" id="73567at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030554">
        <property type="term" value="F:adenyl nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043168">
        <property type="term" value="F:anion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051262">
        <property type="term" value="P:protein tetramerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08235">
        <property type="entry name" value="iditol_2_DH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050129">
        <property type="entry name" value="Zn_alcohol_dh"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43401">
        <property type="entry name" value="L-THREONINE 3-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43401:SF2">
        <property type="entry name" value="L-THREONINE 3-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="5">
        <location>
            <begin position="8"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF84235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="348" mass="37563" checksum="CB058C8DE0CD2ED3" modified="2014-10-29" version="1">MKAVFVKGHSAVSVDEIKAPEMASEGDVLVRMRACGLCGSDLEKVYGEYGMSSGRLGHEPAGEVVAVGKNAKGFAPGDRVFIHHHVPCYSCHYCLHGDYTMCPEYQKSNIAPCGLAEQFIVPEWNVSRGGLIKLPAGMTFDEASLVEPLACCIRAWNKCNFQRGDDIAVLGAGPAGLMHVILAKAFGAGRVFVSDINDFRLDFARKKYGVETFNSISTPDFAQKIKEQTGGRGVDIAVVATGSTKALLQSFDMTRRAGKIMLFGVPSKGSAVSYDMSKLYSNEHSLIPSYAASEVETNQAIKLIAEKRIEIASLITHRFDISDASEAIKCAHEAKDAMKVIVTTGNNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSX4</accession>
    <name>A0A075MSX4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl22</name>
        <name evidence="7" type="ORF">NTE_01832</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="4 6">This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 6">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_075055949.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSX4"/>
    <dbReference type="STRING" id="1459636.NTE_01832"/>
    <dbReference type="GeneID" id="41597596"/>
    <dbReference type="KEGG" id="nev:NTE_01832"/>
    <dbReference type="eggNOG" id="arCOG04098">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083987_0_2_2"/>
    <dbReference type="OrthoDB" id="314984at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="entry name" value="Ribosomal protein L22/L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01331_A">
        <property type="entry name" value="Ribosomal_uL22_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_uL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057265">
        <property type="entry name" value="Ribosomal_uL22_arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005721">
        <property type="entry name" value="Ribosomal_uL22_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_uL22_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003260">
        <property type="entry name" value="PRK04223.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01038">
        <property type="entry name" value="uL22_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11593">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11593:SF10">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="Ribosomal protein L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 6" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF83892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="157" mass="17932" checksum="7D7F5BC06558739D" modified="2014-10-29" version="1">MPQFSYSFQNFDKARHVRAAVREKSISHKHSREIAVAIKGMSIEKAREFLENVVAKKVAVPYRRYHNEVAHRTNIRDGFAAGRFPQKAANEFLRLLDNLESNAEYKGMDLDRLRIVSAVVHKGTKLKRFTPRAMGRSSPKVDTLVHVELVAQEVSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MT86</accession>
    <name>A0A075MT86_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">3-dehydroquinate synthase II</fullName>
            <ecNumber evidence="5">1.4.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_01959</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.4.1.-" evidence="5"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700674.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MT86"/>
    <dbReference type="STRING" id="1459636.NTE_01959"/>
    <dbReference type="GeneID" id="41597707"/>
    <dbReference type="KEGG" id="nev:NTE_01959"/>
    <dbReference type="eggNOG" id="arCOG04353">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056379_0_0_2"/>
    <dbReference type="OrthoDB" id="10265at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003856">
        <property type="term" value="F:3-dehydroquinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002812">
        <property type="entry name" value="DHQS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030960">
        <property type="entry name" value="DHQS/DOIS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056179">
        <property type="entry name" value="DHQS_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33563">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33563:SF1">
        <property type="entry name" value="3-DEHYDROQUINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01959">
        <property type="entry name" value="DHQS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26558">
        <property type="entry name" value="DHQS_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006655">
        <property type="entry name" value="DHQ_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-dehydroquinate synthase N-terminal" evidence="3">
        <location>
            <begin position="40"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="3-dehydroquinate synthase C-terminal" evidence="4">
        <location>
            <begin position="181"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF26558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF84017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="356" mass="38939" checksum="5E60DDCF3BC1446A" modified="2014-10-29" version="1">MVEQAAKSKELIVKPTVAKAGLEKFLSKLKNVSMLNADPKVVAGKKFQTIFESNDADLVICKTFDQMKAAKAAGKTFGYYKKVLSNADVDEIERASQAEGASFVVVDASDWKIIPLENIIAKLHKSKTKVYTTASSSKEVKTMFSVLELGVDGVILSTDSEDEVEKASQQLSTVRFPIKVARITEVKDVGTGERVCVDTASMMGMGEGMLIGSRSNFMLLVHNESVGSSFTSPRPFRVNAGAVYCYTITPDGNTRYLSELESGTEVWIVNKDGQSRRATVGRSKIETRPLRLLRAEIEGETGTVILQNAETIRLMKPDGKLLSVTEVKPGDEVMGYAKPASGRHFGMEVDEYIVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTE6</accession>
    <name>A0A075MTE6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02826</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987008.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTE6"/>
    <dbReference type="GeneID" id="41598511"/>
    <dbReference type="KEGG" id="nev:NTE_02826"/>
    <dbReference type="eggNOG" id="arCOG08793">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_658253_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="417" mass="45893" checksum="33374D1DBE3CC6A2" modified="2014-10-29" version="1">MNAVIGRMMLSICLALAISIPFLTQQFSFKARAYAQAQPCGDGTIAMNPDKGADFNRDRAPHKIGDALTDVDVILTPHAPYLPRNTAFLPANNYNGNLSASIRLCDISDGHTILHTTYNIAVKKITQNKVLFHETFYSKNGTLVMNMLHSVEQAKTGDGTRSAGTVATVDEGQRNSSSLMNNAVVVANHNDTVTIQVPEGFSTGLYLFQIRILAANTGGVRPSVFNESDAPTFNVWRYLEQALPEPIITANGKTYNLTVLTQSDKPEDFRFDDKKHTLTWSIPYFWNTTELTPKDMVVHQDIMIPNSVNELSGAMAINATVNGFPITYKEGAAFIDRTSTNSTLVIHLILNKDGILRMAKEVPTNTSRMYFSVSFSQAVVPEFHAPSSIFPSIAGFAVGIIVLIHRFRSVSKEGEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTG2</accession>
    <name>A0A075MTG2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701056.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTG2"/>
    <dbReference type="STRING" id="1459636.NTE_02440"/>
    <dbReference type="GeneID" id="41598147"/>
    <dbReference type="KEGG" id="nev:NTE_02440"/>
    <dbReference type="HOGENOM" id="CLU_2874904_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="63" mass="6669" checksum="6230DBECB6ECF721" modified="2014-10-29" version="1">MVSTTAAIVAGLVAGVALIVAFSVLDANPSFQNKYAKNNKTVEVTIPEARQTNAQSTIILNHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTJ4</accession>
    <name>A0A075MTJ4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N,N-dimethylformamidase beta subunit-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_02045</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700740.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTJ4"/>
    <dbReference type="GeneID" id="41597784"/>
    <dbReference type="KEGG" id="nev:NTE_02045"/>
    <dbReference type="eggNOG" id="arCOG14091">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1021580_0_0_2"/>
    <dbReference type="OrthoDB" id="10079at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046540">
        <property type="entry name" value="DMFA2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20254">
        <property type="entry name" value="DMFA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="N,N-dimethylformamidase beta subunit-like C-terminal" evidence="2">
        <location>
            <begin position="45"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF84102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="237" mass="26439" checksum="7654A56F23697D0B" modified="2014-10-29" version="1">MSGRDAVNGKNFRTGIVRLAYGSMVIVLFFAMAIAPPQASAIKLHSIVTIKPTFTIAAYQPRGFYDYYRNTCSTRCLTVRLRPAQYTSDMDYAGSSNALKKIESLGISDVVTDEQVTKNPSILASYEKVIVLHNEYVTQAEFDAITRHPDVLYLYPNALYALVSYNPVSNTITLQKGHGYKGVNDAFNWPPSRSTKDEYNTSCKNWQFEKASNGSVLDCYPEFDILHDAKLMSLVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTN9</accession>
    <name>A0A075MTN9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02081</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700768.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTN9"/>
    <dbReference type="STRING" id="1459636.NTE_02081"/>
    <dbReference type="GeneID" id="41597816"/>
    <dbReference type="KEGG" id="nev:NTE_02081"/>
    <dbReference type="eggNOG" id="arCOG08805">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100103_1_0_2"/>
    <dbReference type="OrthoDB" id="8756at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="Ribbon-helix-helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="176" mass="20610" checksum="C1AD0AB01CB60C9A" modified="2014-10-29" version="1">MADSGSMSITFRFPKSILQELKEDAEHKNISINALLNQIVASYVEWHARATKAGFITVSRVMIKTMFDSLTEEEIDRLAKSSAEEMKDMCLLMVRKHTQRSILEFMERWVRMSDFGYRHMIDESSSLHTYIIQHDMGYKWSHYLSKLFSYTAEEVVLFKPEISIGKDMVVLKIREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTP0</accession>
    <name>A0A075MTP0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Adenosylhomocysteinase</fullName>
            <ecNumber evidence="5">3.13.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">S-adenosyl-L-homocysteine hydrolase</fullName>
            <shortName evidence="5">AdoHcyase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ahcY</name>
        <name evidence="10" type="ORF">NTE_02459</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine</text>
            <dbReference type="Rhea" id="RHEA:21708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="3.13.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 7">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="5 7">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 8">Belongs to the adenosylhomocysteinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.13.2.1" evidence="5"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148702138.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTP0"/>
    <dbReference type="STRING" id="1459636.NTE_02459"/>
    <dbReference type="GeneID" id="41598166"/>
    <dbReference type="KEGG" id="nev:NTE_02459"/>
    <dbReference type="eggNOG" id="arCOG04137">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025194_2_1_2"/>
    <dbReference type="OrthoDB" id="8479at2157"/>
    <dbReference type="UniPathway" id="UPA00314">
        <property type="reaction ID" value="UER00076"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004013">
        <property type="term" value="F:adenosylhomocysteinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071269">
        <property type="term" value="P:L-homocysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033353">
        <property type="term" value="P:S-adenosylmethionine cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00401">
        <property type="entry name" value="SAHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000004">
        <property type="entry name" value="Adenosylhomocysteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1480">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00563">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042172">
        <property type="entry name" value="Adenosylhomocyst_ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000043">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015878">
        <property type="entry name" value="Ado_hCys_hydrolase_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020082">
        <property type="entry name" value="S-Ado-L-homoCys_hydrolase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00936">
        <property type="entry name" value="ahcY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004005">
        <property type="entry name" value="PRK05476.2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420">
        <property type="entry name" value="ADENOSYLHOMOCYSTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420:SF0">
        <property type="entry name" value="ADENOSYLHOMOCYSTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05221">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00670">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001109">
        <property type="entry name" value="Ad_hcy_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00996">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00997">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00738">
        <property type="entry name" value="ADOHCYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00739">
        <property type="entry name" value="ADOHCYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5 7" id="KW-0520">NAD</keyword>
    <keyword evidence="2 5" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S-adenosyl-L-homocysteine hydrolase NAD binding" evidence="9">
        <location>
            <begin position="190"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <begin position="156"/>
            <end position="158"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="219"/>
            <end position="224"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="221"/>
            <end position="226"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <begin position="298"/>
            <end position="300"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001109-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIF84508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="423" mass="45438" checksum="DC06E0C2E9DA6731" modified="2014-10-29" version="1">MEYRVKDLALAEEGKRRIDWAEAHMPVLVALRKKYSETKPLKGIRVAGCLHVTKETGVLVRTLKAAGAELSWCGCNPLSTQDDVAASLVKHDGVSVFASRGVSTKEYYDDIHASMRLNPHITIDDGADLTVEMHKALEQGRNGGLAGPLYGGTEETTTGVVRLRALQKSGRLLYPVIAVNDAETKHDFDNIYGTGQSALDGIIRATNVLLSGKNVVVAGYGHVGKGVAKRASGLGANVIVTEVDPIAALKAKLDGFSVAPMNKAAEVGDVFITTTGCKDVIVSDDISKMKDGAILANAGHFNVEISIPDLEKQSTGTKEINQHTMQYSLKNGSRVYLIGEGRLVNLAAAEGHPSEVMDMSFANQFLSVLRLAQSKGTMKPIVYNIDKQQDQEIALAKLQSMGVDIDTLTPEQKVYLDGFSEGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTP5</accession>
    <name>A0A075MTP5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02086</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700771.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTP5"/>
    <dbReference type="STRING" id="1459636.NTE_02086"/>
    <dbReference type="GeneID" id="41597820"/>
    <dbReference type="KEGG" id="nev:NTE_02086"/>
    <dbReference type="eggNOG" id="arCOG08684">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128582_1_0_2"/>
    <dbReference type="OrthoDB" id="875at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="130" mass="14418" checksum="8B1AC5B0067DAB8D" modified="2014-10-29" version="1">MADAKQFCADVLALDASIRFAGVADSMGMSVHYVYRKDLVPLLSQEETIKSMLQAVLRSGTRLTLESKLGECVYTLSLYKKVKRITIPLRPPTTNGQNAILMVSLDASVDHDAVIDGKIMPFLRQARLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTT2</accession>
    <name>A0A075MTT2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Trypsin-like serine protease with C-terminal PDZ domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_02504</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701107.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTT2"/>
    <dbReference type="STRING" id="1459636.NTE_02504"/>
    <dbReference type="GeneID" id="41598208"/>
    <dbReference type="KEGG" id="nev:NTE_02504"/>
    <dbReference type="eggNOG" id="arCOG02833">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020120_2_0_2"/>
    <dbReference type="OrthoDB" id="350578at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06779">
        <property type="entry name" value="cpPDZ_Deg_HtrA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051201">
        <property type="entry name" value="Chloro_Bact_Ser_Proteases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43343">
        <property type="entry name" value="PEPTIDASE S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43343:SF3">
        <property type="entry name" value="PROTEASE DO-LIKE 8, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13365">
        <property type="entry name" value="Trypsin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="279"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF84553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="405" mass="42533" checksum="757037DE27387E28" modified="2014-10-29" version="1">MHRGLLAAAVVAAAVAIFFAYSQFSSLDWTPRTQLPDISKLITDNTDNTSDNPRQGLQNSAFEVGRVSTVEAADSEMTLPDLFDKAGPSVVQVSAGNDASEQGKLGSGFVYDDNGHIVTNLHVASGSNQLDVTFEDGTIYRATLLGSDPFTDLAVLYIKDAPKDKLVPLPLADSTKIRVGEQVAAIGNPFGLSSSMTAGIVSGVGRLIPSQDSGPLPFFIPDIIQTDAPINPGNSGGPLLDMRGQVIGINSAIRSTTGEFAGIGFAVPSNTISKIVPSLIKTGKFQHPWVGISGADMTPGLANALKLTEPRGVLVVEVIGGSPAEKAGIKAGDTPTKVDGRTVPLGGDIVLELDGHQVRKVDDILVYLQREKSVGDNMDVTVLRGGQLQHIQVHLDPRPSTQESP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTW2</accession>
    <name>A0A075MTW2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CCA-adding enzyme</fullName>
            <ecNumber evidence="10">2.7.7.72</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">CCA tRNA nucleotidyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">tRNA CCA-pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">tRNA adenylyl-/cytidylyl- transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">tRNA nucleotidyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">tRNA-NT</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">cca</name>
        <name evidence="14" type="ORF">NTE_03046</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. tRNA 3'-terminal CCA addition is required both for tRNA processing and repair. Also involved in tRNA surveillance by mediating tandem CCA addition to generate a CCACCA at the 3' terminus of unstable tRNAs. While stable tRNAs receive only 3'-terminal CCA, unstable tRNAs are marked with CCACCA and rapidly degraded.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a tRNA precursor + 2 CTP + ATP = a tRNA with a 3' CCA end + 3 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14433"/>
            <dbReference type="Rhea" id="RHEA-COMP:10465"/>
            <dbReference type="Rhea" id="RHEA-COMP:10468"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:74896"/>
            <dbReference type="ChEBI" id="CHEBI:83071"/>
            <dbReference type="EC" id="2.7.7.72"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a tRNA with a 3' CCA end + 2 CTP + ATP = a tRNA with a 3' CCACCA end + 3 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:76235"/>
            <dbReference type="Rhea" id="RHEA-COMP:10468"/>
            <dbReference type="Rhea" id="RHEA-COMP:18655"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:83071"/>
            <dbReference type="ChEBI" id="CHEBI:195187"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="10">A single active site specifically recognizes both ATP and CTP and is responsible for their addition.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.72" evidence="10"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385597.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTW2"/>
    <dbReference type="STRING" id="1459636.NTE_03046"/>
    <dbReference type="GeneID" id="41598714"/>
    <dbReference type="KEGG" id="nev:NTE_03046"/>
    <dbReference type="eggNOG" id="arCOG04249">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044679_1_0_2"/>
    <dbReference type="OrthoDB" id="7378at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004810">
        <property type="term" value="F:CCA tRNA nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160016">
        <property type="term" value="F:CCACCA tRNA nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042245">
        <property type="term" value="P:RNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001680">
        <property type="term" value="P:tRNA 3'-terminal CCA addition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05400">
        <property type="entry name" value="NT_2-5OAS_ClassI-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.30">
        <property type="entry name" value="CCA tRNA nucleotidyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.590">
        <property type="entry name" value="Poly(A) polymerase predicted RNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01264">
        <property type="entry name" value="CCA_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048833">
        <property type="entry name" value="CAA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008229">
        <property type="entry name" value="CCA-adding_arc"/>
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        <property type="entry name" value="NT_2-5OAS_ClassI-CCAase"/>
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        <property type="entry name" value="tRNA_NucTransf2"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="25A_SYNTH_3"/>
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    </dbReference>
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    <keyword evidence="3 10 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0692">RNA repair</keyword>
    <keyword evidence="9 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 10 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 10" id="KW-0819">tRNA processing</keyword>
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        <location>
            <begin position="34"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA nucleotidyltransferase substrate binding" evidence="12">
        <location>
            <begin position="159"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="CCA-adding enzyme C-terminal" evidence="13">
        <location>
            <begin position="285"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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    <feature type="binding site" evidence="10">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
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        <location>
            <position position="60"/>
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        <ligand>
            <name>ATP</name>
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        </ligand>
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        </location>
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            <name>CTP</name>
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        </ligand>
    </feature>
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        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
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        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
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        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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    <feature type="binding site" evidence="10">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
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        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>ATP</name>
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        </ligand>
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        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
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            <position position="173"/>
        </location>
        <ligand>
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            <position position="173"/>
        </location>
        <ligand>
            <name>CTP</name>
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        </ligand>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
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        <source>
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        </source>
    </evidence>
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        </source>
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        </source>
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    </evidence>
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            <dbReference type="HAMAP-Rule" id="MF_01264"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AIF85081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="453" mass="50249" checksum="E5C1A96830B0CDB9" modified="2014-10-29" version="1">MTDNTIEGVLAKALALCNPTAAEEKRITAVAEEAKKLVEQKSKATSSEVREIIFGGSFAKGTWLHGDADIDIFLKVDPSVSEERFEKLGVEIGRQALRKYKPKLRYSDHPYVEATVRGIRINVVPCYDVQRGQWKSAADRSPFHTQYIMETLDVAKKEQVRLLKKFLKSTGIYGAEISTGGFSGYVSEVLIAKYGSLEGALAAAAEFRQGQVVSVGDYDADISKGFSSPLVIIDPIDPRRNLGTAISPESVGRFALAARAFLHNPSEKFFARQKPSVNKKLYRNVLVVEFSHRERSPDTIWGQLKRSANSVAKQLELAGFTVFRTTCNTDEKKSGAFAFLLESLALPEYMMRKGPEIARAKDMESFVMAARSLAMWADREMRVSAIVERKATDAGQLVKTLLGRPPEANGIARDMITGRVKVYSASGRRRFPGLVKEAVDELVSTENLIFFFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MU43</accession>
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        <recommendedName>
            <fullName evidence="1">O-methyltransferase dimerisation domain-containing protein</fullName>
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        <name evidence="2" type="ORF">NTE_00741</name>
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        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
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        <lineage>
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        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Winged helix' DNA-binding domain"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="O-methyltransferase dimerisation" evidence="1">
        <location>
            <begin position="28"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08100"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AIF82819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="84" mass="9366" checksum="3867950D29725A6E" modified="2014-10-29" version="1">MIYVFIQHAYTHMSSSSAPSSFARSEFKMLTGFWVSKALMAAVEFDLFTKLAGGRQITLQELQKTLGMERRPLAGPAEIAISYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MU77</accession>
    <name>A0A075MU77_9ARCH</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">NTE_00801</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
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            <taxon>Nitrososphaerales</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
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        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="228" mass="24378" checksum="8550E8FAF9150941" modified="2014-10-29" version="1">MRAAHFAVVVAALFALATFSTILKDAYSHSMGPLSIRADIPVYRIKLGEAQTQEMRVCSMLPGKLVIDSVTFNGTNSDWARVEKGSFPVIVTPAANMTASATIPLSVTVPSNFTGDHAIIQTIVNTMSPLALPVQGNLIVLITNNTVASTQNLLECKSLLEIQRGIQYSAIIVGAIGAGLIAVGYFVFRRSKAKPQEQRARRGAKILLVVLGIIGSFLIVEAILSLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUA5</accession>
    <name>A0A075MUA5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Histidinol-phosphate aminotransferase</fullName>
            <ecNumber evidence="10">2.6.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NTE_03197</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SR1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.9" evidence="10"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701662.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUA5"/>
    <dbReference type="STRING" id="1459636.NTE_03197"/>
    <dbReference type="GeneID" id="41598854"/>
    <dbReference type="KEGG" id="nev:NTE_03197"/>
    <dbReference type="eggNOG" id="arCOG04273">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_3_1_2"/>
    <dbReference type="OrthoDB" id="9929at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004400">
        <property type="term" value="F:histidinol-phosphate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005861">
        <property type="entry name" value="HisP_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01141">
        <property type="entry name" value="hisC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42885:SF2">
        <property type="entry name" value="HISTIDINOL-PHOSPHATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42885">
        <property type="entry name" value="HISTIDINOL-PHOSPHATE AMINOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 10" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="9">
        <location>
            <begin position="29"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIF85226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="372" mass="40995" checksum="8E7F58BCB6B40569" modified="2014-10-29" version="1">MTAAKTVEKELKRIAKLDRYVRPEKITGAIKLDSNENFALDAKFVLQIVTEAARRVDLREYPIDELDGLYAQLAKYTGINEKYIGAGSGSDQIIELLLTTLASNNNKKGKKGSSGRAAVFVPTFSYFINRCELHGMAVDKVPLEKNFELDIDRFAKSAKKAGLVYLCSPNNPTGGQIPKKDAVELLDRLDYDNALVLVDEAYSDFASYSLAKEATKRDNVIVLRTLSKAFGLAGARVGYMIAGEKTAGLFRSTIQSPYPVSTLSLTIATGVLERADFVKKTIEDVKGERRRVFESLDEIKGIKAFRSDANFLFVETGKKKRYSAIAKALEKEGIVVKMLGNVSGHTGCMRVTIGTQEMNDRFLKCVREGAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUD1</accession>
    <name>A0A075MUD1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">tRNA N6-adenosine threonylcarbamoyltransferase</fullName>
            <ecNumber evidence="8">2.3.1.234</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">N6-L-threonylcarbamoyladenine synthase</fullName>
            <shortName evidence="8">t(6)A synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">t(6)A37 threonylcarbamoyladenosine biosynthesis protein Kae1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">tRNA threonylcarbamoyladenosine biosynthesis protein Kae1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">kae1</name>
        <name evidence="10" type="ORF">NTE_02759</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>L-threonylcarbamoyladenylate + adenosine(37) in tRNA = N(6)-L-threonylcarbamoyladenosine(37) in tRNA + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="8">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="8"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701312.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUD1"/>
    <dbReference type="STRING" id="1459636.NTE_02759"/>
    <dbReference type="GeneID" id="41598448"/>
    <dbReference type="KEGG" id="nev:NTE_02759"/>
    <dbReference type="eggNOG" id="arCOG01183">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023208_2_2_2"/>
    <dbReference type="OrthoDB" id="6818at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:tRNA N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000037">
        <property type="entry name" value="Probable tRNA N6-adenosine threonylcarbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01446">
        <property type="entry name" value="Kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034680">
        <property type="entry name" value="Kae1_archaea_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017860">
        <property type="entry name" value="Peptidase_M22_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03722">
        <property type="entry name" value="arch_KAE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00329">
        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF14">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01016">
        <property type="entry name" value="GLYCOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 8" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Gcp-like" evidence="9">
        <location>
            <begin position="30"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="130"/>
            <end position="134"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIF84800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="332" mass="35612" checksum="1CB446540063FD0F" modified="2014-10-29" version="1">MLCLGIESTAHTFGCAVVDRNGKVLSDARDAYKAPEGKGIHPREASRHHIEVSSQVLRQALEDASATMKDVDIIGYSAGPGLGPCLRVGAVVARTLAGFYKKPLVPVNHALGHIELGAMLTGAHDPLVLLVSGGHTMILAFSHGRWRVFGETLDITIGQLLDQFGRAMGFASPCGGKVEQLAGESQQKNYTQLPYVVKGNDVSFSGLLTAAVRLAQKDKADLSDVCYSLQETSFAMLAEAVERALSFTGKREMMIVGGVSANRRLASMLESACARQDSRFFACPIKFAGDNGAQIAWTALLDYAATKNKVAVKDASVTQSWRLDTVNVAWRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUD6</accession>
    <name>A0A075MUD6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GTP cyclohydrolase 1</fullName>
            <ecNumber evidence="4">3.5.4.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">GTP cyclohydrolase I</fullName>
            <shortName evidence="4">GTP-CH-I</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">folE</name>
        <name evidence="6" type="ORF">NTE_02764</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17473"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58462"/>
            <dbReference type="EC" id="3.5.4.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 4">Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homopolymer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GTP cyclohydrolase I family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.16" evidence="4"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987004.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUD6"/>
    <dbReference type="STRING" id="1459636.NTE_02764"/>
    <dbReference type="GeneID" id="41598453"/>
    <dbReference type="KEGG" id="nev:NTE_02764"/>
    <dbReference type="eggNOG" id="arCOG04542">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049768_3_3_2"/>
    <dbReference type="UniPathway" id="UPA00848">
        <property type="reaction ID" value="UER00151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003934">
        <property type="term" value="F:GTP cyclohydrolase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1130.10:FF:000001">
        <property type="entry name" value="GTP cyclohydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.286.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00223">
        <property type="entry name" value="FolE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043134">
        <property type="entry name" value="GTP-CH-I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001474">
        <property type="entry name" value="GTP_CycHdrlase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018234">
        <property type="entry name" value="GTP_CycHdrlase_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020602">
        <property type="entry name" value="GTP_CycHdrlase_I_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006825">
        <property type="entry name" value="PRK09347.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006826">
        <property type="entry name" value="PRK09347.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109:SF7">
        <property type="entry name" value="GTP CYCLOHYDROLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109">
        <property type="entry name" value="GTP CYCLOHYDROLASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01227">
        <property type="entry name" value="GTP_cyclohydroI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55620">
        <property type="entry name" value="Tetrahydrobiopterin biosynthesis enzymes-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00859">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00860">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="GTP cyclohydrolase I" evidence="5">
        <location>
            <begin position="13"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF84805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="188" mass="21437" checksum="B77446D1D32E98BA" modified="2014-10-29" version="1">MKDNGKINKKKIAKLLRQLLIELGENPDREGLMGTPDRMANMYEEILGGYTMDAELDVTFSDETDVIVARDIQFYSMCEHHMLPFFGKVHVAYVPAGKVFGVSKLVRLVEKYSRRLQIQERLTKEVADELVRMGVKGAMVIAEGDHLCMRMRGVRNNSSMLTIAYRGVMEQKDLREHVLAMIKAPKAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUH3</accession>
    <name>A0A075MUH3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Aspartate--tRNA(Asp/Asn) ligase</fullName>
            <ecNumber evidence="9">6.1.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Aspartyl-tRNA synthetase</fullName>
            <shortName evidence="9">AspRS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Non-discriminating aspartyl-tRNA synthetase</fullName>
            <shortName evidence="9">ND-AspRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">aspS</name>
        <name evidence="11" type="ORF">NTE_02820</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Asx) + L-aspartate + ATP = L-aspartyl-tRNA(Asx) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:18349"/>
            <dbReference type="Rhea" id="RHEA-COMP:9710"/>
            <dbReference type="Rhea" id="RHEA-COMP:9711"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.23" evidence="9"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987007.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUH3"/>
    <dbReference type="STRING" id="1459636.NTE_02820"/>
    <dbReference type="GeneID" id="41598505"/>
    <dbReference type="KEGG" id="nev:NTE_02820"/>
    <dbReference type="eggNOG" id="arCOG00406">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004553_2_1_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050560">
        <property type="term" value="F:aspartate-tRNA(Asn) ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00776">
        <property type="entry name" value="AsxRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000038">
        <property type="entry name" value="Aspartate--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02075">
        <property type="entry name" value="Asp_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004523">
        <property type="entry name" value="Asp-tRNA_synthase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00458">
        <property type="entry name" value="aspS_nondisc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003483">
        <property type="entry name" value="PRK05159.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450:SF1">
        <property type="entry name" value="ASPARTATE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450">
        <property type="entry name" value="ASPARTYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="10">
        <location>
            <begin position="151"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Aspartate" evidence="9">
        <location>
            <begin position="206"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="227"/>
            <end position="229"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="235"/>
            <end position="237"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="369"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="369"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="369"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="372"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="372"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="376"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="417"/>
            <end position="420"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for tRNA non-discrimination" evidence="9">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIF84860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="446" mass="50620" checksum="BFC424F739F30675" modified="2014-10-29" version="1">MEEELLKEEDLGQWRRTHYSKEVGPAMADREVVIMGWVSSVRDHGNISFIIIKDMHGEVQVTAKKSEVGEQLFALAKEVKEHTSLGVRGKVRPQEKAPNGAEVVPAEIKAFSVAKKAAPFMTTGKSSPVGIDTRLDLRAVDLRRQQLGSIFRIRQTVVNAIREFLSRQDFAEVSTPKMIATATEGGAALFPIFYYDREAFLAQSPQLYKEQLTMAFESVFEIGPIFRAEPSRTNRHLSEATSVDVERAFADYGDVMALLERMIIHIIDSVKDRNKADLEFLEIAMPALELPFPKYSYSDLIDKLQEAGERIQWGDDISPQVMKSLQDERLNGFYFIVDWPTSTKPFYVKPRADDPKVCESFDLMYGPLEMSSGSTRINRKNQLIERMQKQGLKPDAFDYHLRVFDFGVPPHAGFGMGLERLLMALAKIENIRDATFYPRDIDRLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUI4</accession>
    <name>A0A075MUI4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helix-turn-helix domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_02837</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701375.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUI4"/>
    <dbReference type="STRING" id="1459636.NTE_02837"/>
    <dbReference type="GeneID" id="41598519"/>
    <dbReference type="KEGG" id="nev:NTE_02837"/>
    <dbReference type="eggNOG" id="arCOG04362">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062767_3_0_2"/>
    <dbReference type="OrthoDB" id="11410at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013561">
        <property type="entry name" value="FilR1_middle_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057527">
        <property type="entry name" value="HVO_A0261-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051797">
        <property type="entry name" value="TrmB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34293">
        <property type="entry name" value="HTH-TYPE TRANSCRIPTIONAL REGULATOR TRMBL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34293:SF1">
        <property type="entry name" value="HTH-TYPE TRANSCRIPTIONAL REGULATOR TRMBL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08350">
        <property type="entry name" value="FilR1_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25213">
        <property type="entry name" value="HVO_A0261_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HVO-A0261-like N-terminal" evidence="2">
        <location>
            <begin position="23"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Methanogenesis regulatory protein FilR1 middle" evidence="1">
        <location>
            <begin position="143"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF84875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="273" mass="30600" checksum="8EAAD6C3B90AA45B" modified="2014-10-29" version="1">MHSSIPVDGSDEPVEAASLFMELASETRCAIIASVANRPAKLSTLARELGVTVQDVHRNANRLLESGILERRDGEFYLSEFGRAITMQLPYFRFMKKHSRFFQEHTLAFLPDKFVHRMGALEKCRMVETVTVVMQDLKKLEMSATRQLKVMVSQAWPEEGQILIDRARRGVELRTIIGCNTVFPQNVMDEIIPAMAKLTSANAIEQRMVDKVSTALYIADGRAAIMFPNAKGEVDMGAMLAGDSPEFVEWCTDLFDHAWLHAGPADVRKAKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUL7</accession>
    <name>A0A075MUL7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00928</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUL7"/>
    <dbReference type="STRING" id="1459636.NTE_00928"/>
    <dbReference type="KEGG" id="nev:NTE_00928"/>
    <dbReference type="HOGENOM" id="CLU_1830506_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055898">
        <property type="entry name" value="DUF7475"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24287">
        <property type="entry name" value="DUF7475"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="140" mass="14882" checksum="41FE680C2214C464" modified="2014-10-29" version="1">MAMATKRVLYYAAAAATAVGGILHLILAPNMLGFNINTGLFFLIGGIAQLFWVVPMVKRWGRPWYAIGIGGTAVLVAVYFITRMPGNPITGRGGGVNSMAIAVEVAQLVFIGLCIAILAMAGKKKEEEEEEVNKNDKAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUM4</accession>
    <name>A0A075MUM4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peroxiredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_02777</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701327.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUM4"/>
    <dbReference type="STRING" id="1459636.NTE_02777"/>
    <dbReference type="GeneID" id="41598466"/>
    <dbReference type="KEGG" id="nev:NTE_02777"/>
    <dbReference type="eggNOG" id="arCOG00310">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_14_2_2"/>
    <dbReference type="OrthoDB" id="6924at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03018">
        <property type="entry name" value="PRX_AhpE_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050455">
        <property type="entry name" value="Tpx_Peroxidase_subfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43110">
        <property type="entry name" value="THIOL PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43110:SF1">
        <property type="entry name" value="THIOL PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="8"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity" evidence="3">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF84818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="167" mass="18680" checksum="AE5E53880B3A6C53" modified="2014-10-29" version="1">MAAAKSSLKIGQKAPEFELPDQDLKNRKLSDFRGKKTILAFFPAAESSVCTAEMCAIRDSLDELRDYGANVLGISVDGPFVNKAFANNHHLSFPVLSDYGRKVIKKYGIVMKKLASMPDYNAAKRSVFILDEQGKVRYRWVSDNPLVEPNYAEIKEFLKKNNGSSNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUM8</accession>
    <name>A0A075MUM8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03342</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUM8"/>
    <dbReference type="STRING" id="1459636.NTE_03342"/>
    <dbReference type="KEGG" id="nev:NTE_03342"/>
    <dbReference type="eggNOG" id="arCOG10350">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064880_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="364" mass="38336" checksum="6AAFFB008122F754" modified="2014-10-29" version="1">MLKLTTAVVIAVVVAASLMLSSLSAFSIITAAQAQSASTAGAVVPAELDKPFKLKVGLQAAIDSEKIAISFLNVTEDSRCPSDVVCIWQGQASIKISAEANGTDAGQFVLTIGGNEKPSATFGKYYSVKMSGLEPYPVSTNQTEPEDYVATLVVSKVAANSASVHVKATANGTSNSVAAIISGWNFQKEKGTLVMLSRDSAAAIKMAIARFTPAEAQCKSPDARECTDGHIVNSKGIDGDTLHFEVLPGDKLYLAAGGSEYTLDIRQIKARPQHQGSTTTTTITLTEGQRDGPLLVQEIGNGYVKGLNYVEYPLARQEGIPVTLHVGDTVSNGCTVTLTLLKTQQNVSSAVFSKTVDYSRPCPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUN1</accession>
    <name>A0A075MUN1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF790 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03347</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701792.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUN1"/>
    <dbReference type="STRING" id="1459636.NTE_03347"/>
    <dbReference type="GeneID" id="41598996"/>
    <dbReference type="KEGG" id="nev:NTE_03347"/>
    <dbReference type="eggNOG" id="arCOG04356">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038336_0_0_2"/>
    <dbReference type="OrthoDB" id="57367at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008508">
        <property type="entry name" value="Bax1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39640:SF1">
        <property type="entry name" value="DUF790 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39640">
        <property type="entry name" value="VNG6129C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05626">
        <property type="entry name" value="DUF790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="598" mass="67624" checksum="40450DECC2361E9C" modified="2014-10-29" version="1">MLAAPLLRVRTTRNGSIVPLFCTRDEETGLAKRLIQEFEAAWKKRERKAELDDRIAEVESEYNRDFKLVRGLCALLERRCTFESATVSTATTISAATTNVTLVEPAAVRKALFEESSRRGFALTDMERKEIIDIVASRLHLSADAIASIMWSDLDDNLILEKFDAIDAKSLVGWYNLALVQTLLFNCTKLEFSVSGGLNWKRILRRVKRLGLMYYLQQEDHDKSRKRIVCSIEGPLSLFRLTDRYGTALARLLPSIVVLSKGSEWRINAWIMRRTMEGKRTLYEFNLSDSEAPSLLTDPFYYYYNNNNEGSKRGEELQLSPDYFDSAVEEKFARRFEAAAAAGWKLVREPDPLIVSDGRALIPDFMFEKYGKRVYLEIVGFWTPEYLERKLKKLADIIIGNYNAGQATDLFIALNKDLACSNAVLSSLSFHLIPKERLILYGSDAVPIKPVLDYLKSIDKETAEQSISNPNLKAELDRAKDVISIDEIVIENKESNCPSPLPPEVVMKIALRDHGDRYMEVAGTHLISKEKAGRLESLLACIIKFTDACAVLAQNEIPELCQAELVSKLGYDVVWQSMDPGSAVIVKKRNEKKESDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUN9</accession>
    <name>A0A075MUN9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Urease accessory protein UreE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_02887</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701413.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUN9"/>
    <dbReference type="STRING" id="1459636.NTE_02887"/>
    <dbReference type="GeneID" id="41598566"/>
    <dbReference type="KEGG" id="nev:NTE_02887"/>
    <dbReference type="eggNOG" id="arCOG06188">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1639890_0_0_2"/>
    <dbReference type="OrthoDB" id="2171at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00822">
        <property type="entry name" value="UreE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012406">
        <property type="entry name" value="UreE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004029">
        <property type="entry name" value="UreE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036118">
        <property type="entry name" value="UreE_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02814">
        <property type="entry name" value="UreE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036402">
        <property type="entry name" value="Ureas_acces_UreE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00988">
        <property type="entry name" value="UreE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69287">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0533">Nickel</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UreE urease accessory N-terminal" evidence="4">
        <location>
            <begin position="11"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF84925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="174" mass="19997" checksum="A7FF2E3FFFD9E761" modified="2014-10-29" version="1">MTTAMITATSILGNIYRDNSLKEKYRQIPGETVRISRLESQRVRMRKTSDKGTDIAITLPPGSRLRHGDVVLLTDDKKMMVVVELEPENVAVVQVKENTLHKDDLIEVPVRIGHTIGNLHRPIKLEDNKIYFPIQTDSELDMFRKLFGHMNEHLEIKSAKMVFEPEEGMDVHEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MV57</accession>
    <name>A0A075MV57_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03008</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MV57"/>
    <dbReference type="KEGG" id="nev:NTE_03008"/>
    <dbReference type="HOGENOM" id="CLU_1056024_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="263" mass="27953" checksum="939C61333FA7AE90" modified="2014-10-29" version="1">MSSTSSRKIKIAIPALVGGLGVIIAIVFMLSFYSQNSLISNASPDQNLGGSFTVIRCNDVLPATSILETNGFVTIKPRTSATPELTPGVPTSGNEPGIYEFVLKPGSTGIVTMSYDFCAGKGESVVNSSDNKTTSGELKIFFDSFNSTNKGIDKLNAEAFSSSDNTPKDPLSSLMTKNNVLPTTHISHANETGVDIRTSNITRTSDHAVKVTYVISADPSSNKATYIITNFFRTCPGELLTIGDEPNEKSAEWAKGPFYGCVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MV92</accession>
    <name>A0A075MV92_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chaperone protein DnaK</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">HSP70</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Heat shock 70 kDa protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Heat shock protein 70</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">dnaK</name>
        <name evidence="8" type="ORF">NTE_03148</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Acts as a chaperone.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701623.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MV92"/>
    <dbReference type="STRING" id="1459636.NTE_03148"/>
    <dbReference type="GeneID" id="41598807"/>
    <dbReference type="KEGG" id="nev:NTE_03148"/>
    <dbReference type="eggNOG" id="arCOG03060">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005965_2_4_2"/>
    <dbReference type="OrthoDB" id="9944at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10234">
        <property type="entry name" value="ASKHA_NBD_HSP70_DnaK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000014">
        <property type="entry name" value="Chaperone protein DnaK HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000001">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000071">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000003">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="581"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="584"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="609"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF85180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="620" mass="66739" checksum="95C5EA23AEE434E6" modified="2014-10-29" version="1">MGKIIGIDLGTSNSAAAAMIGGKPTIIQAAEGTSVGGKAFPSVVAFTKEGQLIVGEPARRQMISNPEGTVIAAKRKMGTDFRFRVWGKEYTPQQVSSFILQKIKRDAEAFLGETVDRAVITVPAYFNDNQRQATKDAGEIAGLQVVRIINEPTAASLAYGLDKAHKDLKIMVFDLGGGTLDVTIMEMGGGVFQVKSTSGDTQLGGTDMDNTLVEFVVQEFRKQSGIDVRNDKAAMMRVREAAEKAKIELSNVVTTEINLPFLAYDPQAGPKNLVLQLTRAKLEELMRPIVERCRHPMLQALQDAKMTPQEVDKIILIGGPTRMPMVREFVASVMGKEPERGIDPMEAVAMGAAVQGAIIAGDVSTDILLVDVTPLTLGVEVLGGLKEPLIERNTTIPTKKSKVFTTAADYQTAVTIHVVQGERPMASDCVSLGMFNLSGIPPAPRGVPQIEVTFDIDANGILNVAARDIATQKEAKITITANNKLSKDDIEKLKRDSEQFAEADRKKKDEAEARNEADNLVYAAEKLVKQDLKDKIRPEQAERVNKAAQELRDAISSNKFEDIKAKVQELKNILADVSAEAYRSAGAQQQQQQTTSTGPSGPQQQQAGSSGGGGAAGAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVC5</accession>
    <name>A0A075MVC5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02568</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385504.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVC5"/>
    <dbReference type="GeneID" id="43502653"/>
    <dbReference type="KEGG" id="nev:NTE_02568"/>
    <dbReference type="HOGENOM" id="CLU_3147798_0_0_2"/>
    <dbReference type="OrthoDB" id="378678at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="48" mass="5651" checksum="6FC7BF7D8F5FA5B2" modified="2014-10-29" version="1">MTTIEDRVAKLTGKDAEIFQKYDSRALSEKEKEALRKAHQVYKKYCKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVG9</accession>
    <name>A0A075MVG9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Histidinol dehydrogenase</fullName>
            <shortName evidence="6">HDH</shortName>
            <ecNumber evidence="6">1.1.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NTE_03196</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-histidinol + 2 NAD(+) + H2O = L-histidine + 2 NADH + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:20641"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 10">Belongs to the histidinol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.23" evidence="6"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701661.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVG9"/>
    <dbReference type="STRING" id="1459636.NTE_03196"/>
    <dbReference type="GeneID" id="41598853"/>
    <dbReference type="KEGG" id="nev:NTE_03196"/>
    <dbReference type="eggNOG" id="arCOG04352">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006732_3_0_2"/>
    <dbReference type="OrthoDB" id="36308at2157"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00014"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004399">
        <property type="term" value="F:histidinol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06572">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1980:FF:000001">
        <property type="entry name" value="Histidinol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1980">
        <property type="entry name" value="Nitrogenase molybdenum iron protein domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001692">
        <property type="entry name" value="Histidinol_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022695">
        <property type="entry name" value="Histidinol_DH_monofunct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012131">
        <property type="entry name" value="Hstdl_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00069">
        <property type="entry name" value="hisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21256:SF2">
        <property type="entry name" value="HISTIDINE BIOSYNTHESIS TRIFUNCTIONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21256">
        <property type="entry name" value="HISTIDINOL DEHYDROGENASE HDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00815">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000099">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00083">
        <property type="entry name" value="HOLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00611">
        <property type="entry name" value="HISOL_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5 6 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="328"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="329"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="363"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="363"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="417"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="422"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="422"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIF85225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="437" mass="46076" checksum="695C121954D0F623" modified="2014-10-29" version="1">MKIVNVVAEPAAEAAAKLRKSTNKISDALMAQARTIMDDVLAHGDPAVIDYTAKFDGVRLDSLKVSEEEIKGAYDKVTKEQVKALKLMKSRLEKSEIAVLGRLKKNIKVRSEGVLIDRVVQPVASVGCYVPGGKARYPSTLVMCAVPAKVAGVKRIVAISPPTKDDGSIDPLTIVAADICGVNEIYKAGGAQGIAALAYGTQTIKPVSKIVGPGGMFVTAAKIAASSIVSTDMVAGPTELLVYADQSADPRLVAVDLISQAEHSPDTVCGLVTTSEKLAAQVQEQVDAISSGIARSDIVKKSLSENGFVAICKDEKACAEFANEFAPEHLEIISKKKADAFADKIESAGLILIGPDAPSSASDYCLGSNHVLPTLGFGKSRASLSVLDYVKLVNRVKVTKAGLAKIDGAVRAIATAEGLPNHYEAVKARRKRNKKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVH5</accession>
    <name>A0A075MVH5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Imidazoleglycerol-phosphate dehydratase</fullName>
            <shortName evidence="6">IGPD</shortName>
            <ecNumber evidence="6">4.2.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">hisB</name>
        <name evidence="7" type="ORF">NTE_03201</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:11040"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="EC" id="4.2.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the imidazoleglycerol-phosphate dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.19" evidence="6"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701666.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVH5"/>
    <dbReference type="STRING" id="1459636.NTE_03201"/>
    <dbReference type="GeneID" id="41598858"/>
    <dbReference type="KEGG" id="nev:NTE_03201"/>
    <dbReference type="eggNOG" id="arCOG04398">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044308_2_0_2"/>
    <dbReference type="OrthoDB" id="103579at2157"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00011"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004424">
        <property type="term" value="F:imidazoleglycerol-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.40:FF:000001">
        <property type="entry name" value="Imidazoleglycerol-phosphate dehydratase HisB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.40:FF:000003">
        <property type="entry name" value="Imidazoleglycerol-phosphate dehydratase HisB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.40">
        <property type="entry name" value="Imidazole glycerol phosphate dehydratase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00076">
        <property type="entry name" value="HisB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038494">
        <property type="entry name" value="IGPD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000807">
        <property type="entry name" value="ImidazoleglycerolP_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23133:SF2">
        <property type="entry name" value="IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23133">
        <property type="entry name" value="IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE HIS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00475">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="5 6 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF85230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="199" mass="21641" checksum="91EDA7866FDF26C1" modified="2014-10-29" version="1">MAPSPPARKARVERVTKETAVTVEVNVDGTGNTKVKTGLPFIDHLITSIGKHSMIDIALAGKSNDDIVHHLAEDVAIALAQTIDKALGDRARIVRFGTAMVPMDEALAYVAIDLVKRQYHKMDIKLERSSIEGIPREDLEHFCRSLLQGLNACTHMIVEYGDNDHHKVEAALKAFALALRAAASIDGRRKGVPSTKGAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVL3</accession>
    <name>A0A075MVL3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1697 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03171</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701640.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVL3"/>
    <dbReference type="STRING" id="1459636.NTE_03171"/>
    <dbReference type="GeneID" id="41598829"/>
    <dbReference type="KEGG" id="nev:NTE_03171"/>
    <dbReference type="HOGENOM" id="CLU_106303_3_0_2"/>
    <dbReference type="OrthoDB" id="350619at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1260">
        <property type="entry name" value="bacterial protein sp0830 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1280">
        <property type="entry name" value="SP0830-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012545">
        <property type="entry name" value="DUF1697"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36439">
        <property type="entry name" value="BLL4334 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36439:SF1">
        <property type="entry name" value="DUF1697 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08002">
        <property type="entry name" value="DUF1697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008502">
        <property type="entry name" value="UCP008502"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160379">
        <property type="entry name" value="SP0830-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="200" mass="22507" checksum="80101718F425FD60" modified="2014-10-29" version="1">MDILTDIGVVSDKVGAYQYLALLRGINVGGNNVIRMNDLTACFEEMGFADVATYIQSGNILFRTDEQDRARLTDKIERVLSDTFHYNSRVVVITHKQLKSVVEGAPRQFGKDATRYRYDVIFLKEPLTAKTAMKSVSVRDGVDSAYEGKSVLYFSRLIAKAAQSRLPKIITLPVYQNMTIRNWNTTTTLLALMDKKVAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVR8</accession>
    <name>A0A075MVR8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03321</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385649.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVR8"/>
    <dbReference type="STRING" id="1459636.NTE_03321"/>
    <dbReference type="GeneID" id="41598972"/>
    <dbReference type="KEGG" id="nev:NTE_03321"/>
    <dbReference type="HOGENOM" id="CLU_105708_0_0_2"/>
    <dbReference type="OrthoDB" id="11248at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="192" mass="20970" checksum="4AD07370346DF3CA" modified="2014-10-29" version="1">MEFGSATPKYGLVSFTTVVAGDMASSYKAIMAGVVVLIAVAVGMGIWGYGNTIYPIDAALGYLTRAESAQTPEEVAKYVNLARADLPVKGNPVWSFPTARTDFGLIQLELDNIVSRANAISNVEPHSSAYNTGMEDMHVSLDSLQDNIIEALPYMYVSTTNMMFSVVWVAVIMGLFAVMRRGRAKYREEYES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVY7</accession>
    <name>A0A075MVY7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein uS7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rps7</name>
        <name evidence="9" type="ORF">NTE_02745</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 7">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701300.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVY7"/>
    <dbReference type="STRING" id="1459636.NTE_02745"/>
    <dbReference type="GeneID" id="41598434"/>
    <dbReference type="KEGG" id="nev:NTE_02745"/>
    <dbReference type="eggNOG" id="arCOG04254">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063975_0_0_2"/>
    <dbReference type="OrthoDB" id="45346at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14867">
        <property type="entry name" value="uS7_Eukaryote"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="entry name" value="Ribosomal protein S7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00480_A">
        <property type="entry name" value="Ribosomal_uS7_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_uS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026018">
        <property type="entry name" value="Ribosomal_uS7_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_uS7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_uS7_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005716">
        <property type="entry name" value="Ribosomal_uS7_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003106">
        <property type="entry name" value="PRK04027.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01028">
        <property type="entry name" value="uS7_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="Ribosomal protein S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS7" evidence="8">
        <location>
            <begin position="30"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF84787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="201" mass="22544" checksum="8A913912A483DE68" modified="2014-10-29" version="1">MSGKEQVTITLFNKWETKEIEINDPGLKTAISLKPAVLPNTFGRHEHQRLKKADVNIVERLANKMMHFGKKYAKNTGRMGGKKARALNMVRTAFDIIYLETGKNPVELLVRAIENSSPNEDTTRIVYGGVVYHVSVDVAPLRRVDLALRFIAEGVRESTYGNPQTIEEALAKEIILASNNDMASHAVKKKNEQERIAMASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVZ6</accession>
    <name>A0A075MVZ6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Aspartate carbamoyltransferase regulatory chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pyrI</name>
        <name evidence="10" type="ORF">NTE_03289</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Involved in allosteric regulation of aspartate carbamoyltransferase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Contains catalytic and regulatory chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the PyrI family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_075055279.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVZ6"/>
    <dbReference type="STRING" id="1459636.NTE_03289"/>
    <dbReference type="GeneID" id="41598943"/>
    <dbReference type="GeneID" id="74947521"/>
    <dbReference type="KEGG" id="nev:NTE_03289"/>
    <dbReference type="eggNOG" id="arCOG04229">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128576_0_0_2"/>
    <dbReference type="OrthoDB" id="7000at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009347">
        <property type="term" value="C:aspartate carbamoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.20">
        <property type="entry name" value="Aspartate carbamoyltransferase regulatory subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.140">
        <property type="entry name" value="Aspartate carbamoyltransferase regulatory subunit, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00002">
        <property type="entry name" value="Asp_carb_tr_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020545">
        <property type="entry name" value="Asp_carbamoyltransf_reg_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002801">
        <property type="entry name" value="Asp_carbamoylTrfase_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020542">
        <property type="entry name" value="Asp_carbamoyltrfase_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036792">
        <property type="entry name" value="Asp_carbatrfase_reg_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036793">
        <property type="entry name" value="Asp_carbatrfase_reg_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00240">
        <property type="entry name" value="ATCase_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35805">
        <property type="entry name" value="ASPARTATE CARBAMOYLTRANSFERASE REGULATORY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35805:SF1">
        <property type="entry name" value="ASPARTATE CARBAMOYLTRANSFERASE REGULATORY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01948">
        <property type="entry name" value="PyrI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02748">
        <property type="entry name" value="PyrI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57825">
        <property type="entry name" value="Aspartate carbamoyltransferase, Regulatory-chain, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54893">
        <property type="entry name" value="Aspartate carbamoyltransferase, Regulatory-chain, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aspartate carbamoyltransferase regulatory subunit N-terminal" evidence="8">
        <location>
            <begin position="8"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Aspartate carbamoyltransferase regulatory subunit C-terminal" evidence="9">
        <location>
            <begin position="104"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIF85318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="153" mass="17030" checksum="264A6E7968850B53" modified="2014-10-29" version="1">MSEASQLLVRRIKDGTVIDHIESGKALLVLTALAITGREGNVVTVALNVPSSKHGKKDIIKVENRYLETSETNKLALIAPRATINIIKDYKLVEKRKIQLPDSISGIFKCPNLKCITNSGEEIRSKIDVIDKEKLVLKCRYCARVISVDELVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MW54</accession>
    <name>A0A075MW54_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein involved in ribosomal biogenesis, contains PUA domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_01460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700282.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MW54"/>
    <dbReference type="STRING" id="1459636.NTE_01460"/>
    <dbReference type="GeneID" id="41597254"/>
    <dbReference type="KEGG" id="nev:NTE_01460"/>
    <dbReference type="eggNOG" id="arCOG00993">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114385_0_0_2"/>
    <dbReference type="OrthoDB" id="11794at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040598">
        <property type="entry name" value="NIP7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005155">
        <property type="entry name" value="UPF0113_PUA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17833">
        <property type="entry name" value="pre-PUA_NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03657">
        <property type="entry name" value="UPF0113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PUA" evidence="2">
        <location>
            <begin position="95"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF83524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="208" mass="22908" checksum="0DAB7016255D0CFD" modified="2014-10-29" version="1">MAFRELTRQEQTLVNRALDRWGVFEALEGQTFLMHDESGKVCLVSSELANMVKIVQPDTAGLVVGSIGKKKKQFTPALAGASLFARLCDREKKKYYVRVGDNAEKLVLYGRDVMGDSVIEASPELDENDLVIILNAGGEAIGIGRTRFSGKSILQKGRVTITTLADAGSYLRDEDGSNDEEERQAKMTKTTAASSRRQPPKRAFTSYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MW71</accession>
    <name>A0A075MW71_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Putative copper export protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">NTE_02849</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701385.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MW71"/>
    <dbReference type="STRING" id="1459636.NTE_02849"/>
    <dbReference type="GeneID" id="41598531"/>
    <dbReference type="KEGG" id="nev:NTE_02849"/>
    <dbReference type="eggNOG" id="arCOG03564">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG06267">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_302009_0_0_2"/>
    <dbReference type="OrthoDB" id="11063at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046688">
        <property type="term" value="P:response to copper ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032694">
        <property type="entry name" value="CopC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007348">
        <property type="entry name" value="CopC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008457">
        <property type="entry name" value="Cu-R_CopD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014755">
        <property type="entry name" value="Cu-Rt/internalin_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34820">
        <property type="entry name" value="INNER MEMBRANE PROTEIN YEBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34820:SF4">
        <property type="entry name" value="INNER MEMBRANE PROTEIN YEBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04234">
        <property type="entry name" value="CopC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05425">
        <property type="entry name" value="CopD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24684">
        <property type="entry name" value="Vgb_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0186">Copper</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="349"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="442"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="936"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="domain" description="CopC" evidence="11">
        <location>
            <begin position="33"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Copper resistance protein D" evidence="12">
        <location>
            <begin position="350"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="908"/>
            <end position="931"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIF84887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="978" mass="103116" checksum="5E4D2A6F53FDC16B" modified="2014-10-29" version="1">MSVRPSLLYVLAASLLAVTLAFAIMPPQQSFAHPITVSSSPKPFQSLSSSPPEVTVSFTEPIELSYSTISVLGPDGSRVDKNDPHLVNGDTASLGVSLQPNLPDGVYTVTTRVLSAVDGHVVEGAFTFGIGTAVTPSVGPTAAPSQVLSPLESASRFPGMVGQVIVVGAAFGSLWLWRPLSRVPWLASAISSQRAAIDRKMVKLIIIGAAIVIGSNFAMIAVQAIDINAGIAQAIATKFGNVWTTRMIESSILMIITVFVYRKLARTGGLPTKAEMLAILVMGLAVLVTSSLIAHGAATGQIAAILLDFFHNTAASIWIGGLILMGFVAVPKILAMADERARAAAVSILIPRFSTIVVTILGISIITGPLLLFLIESDLSLTLASTYGKVLAIKLALAGVMVAMGGYSQFVIQKKAMVAMVGGSSVQSNGYGRFAKSLKAEAGVGIALLLMVSIMANSSLPAGEFPQYGKQPVDQQAAFAATSQQQTAAAASTKFTQTLYAPSGSVNLGIDPFAVGQNRFTLAFSGSDGKPATDVNAATIKLTQVEKGIGPININATRQQDGTFVGDAAFSLPGMWSIQVEGVRSSSSNIVASLDIPVRPAISSLGFEVKEYKTPESSKPLFPIFDAKRQSIWAGDQTIGSGRIWQFDIATGKYTVHNLTGGVNIASIVRLGSDGKIWYIDPTKYLLGQYDPDTKTNRNFPLPEKGIIAGLAIDNDGNVWMPVTESNKVFKFEPASGKFTAFNIPTPQSGPVNITVDRDGKLWMPESAVGKIAMIDPATGNITEYAPKGSNKLVVPTSIFPDPNGHDLYITEHEGHTVTAFNPLFETFHEYPALNSAGLPFGMAADSYGNIWVAQHTIDRVAVFDPRTGASTEAKIPTSGSFVQYLVADDKGKIWFAEQQGSALGSITITAKPSSPAPQPGNNGTPEEAKSPVTNIGFSLADLAGPAIAAGIVISALMYAKSEMDLKRNVRTAMRNLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MW80</accession>
    <name>A0A075MW80_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleotidyl transferase AbiEii/AbiGii toxin family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85398.1"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="JHP933, nucleotidyltransferase-like core domain"/>
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    </dbReference>
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        <property type="entry name" value="AbiEii"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08843">
        <property type="entry name" value="AbiEii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="AIF85398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="331" mass="39282" checksum="A0F8E84EB01AD147" modified="2014-10-29" version="1">MLKITERILRNWGDLAGIDNLTLAEHDYRISYLLNDIYSNDSLKDNLLLKGGTAINKLHLKNLSRISVDLDFNQIGSKDEVLRNVKRIREILIQIAKEQDQSYKITFDRRYEQTTIHLKYNSVTGQQPVQPIKIEVSHVERFPILKTENKELMLYDTETSTSIGTYRIEELLATKLRALYDRMKGRDLYDLTSSFRLVIDKIVLRKMFLYYFYRDRKVFDPKIFFEKVSSSSYEDDVKGFIRPDIRFDLELAKKEVMQNYNFLRNLDDADKQFLTFARFLLGDDIKKEMKKTILDIVYPFRVLFDGVRDVNPDIFEIRTEDILMYKKPKDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MW94</accession>
    <name>A0A075MW94_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03492</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MW94"/>
    <dbReference type="KEGG" id="nev:NTE_03492"/>
    <dbReference type="HOGENOM" id="CLU_3130673_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="49" mass="5809" checksum="EB590085CB416119" modified="2014-10-29" version="1">MDNDSQLVEIWIKFLSDMGWLIKVRSNNRWLLTDMGKIELAEEWTLVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWR4</accession>
    <name>A0A075MWR4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03052</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701551.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWR4"/>
    <dbReference type="STRING" id="1459636.NTE_03052"/>
    <dbReference type="GeneID" id="41598720"/>
    <dbReference type="KEGG" id="nev:NTE_03052"/>
    <dbReference type="eggNOG" id="arCOG02708">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046006_11_2_2"/>
    <dbReference type="OrthoDB" id="144489at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd07246">
        <property type="entry name" value="VOC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34109">
        <property type="entry name" value="BNAUNNG04460D PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34109:SF1">
        <property type="entry name" value="VOC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="10"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="161" mass="17864" checksum="D368917FCA924E88" modified="2014-10-29" version="1">MAKVSPIPKGYRTITPSIIVKNGTQAIEFYKKAFGAKEGGRFYMPDGKTIAHAELKIGDSRFTLVDEMPEMKAFSPQSVGGPSGSIWLYVKNVDKLFDQAVRAGATATMPVMDMFWGDRAGQLVDPSGHVWWVATRKKNLTKKQMEKAGAEFFASQQQKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWY1</accession>
    <name>A0A075MWY1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thermosome subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NTE_03123</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701602.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWY1"/>
    <dbReference type="STRING" id="1459636.NTE_03123"/>
    <dbReference type="GeneID" id="41598783"/>
    <dbReference type="KEGG" id="nev:NTE_03123"/>
    <dbReference type="eggNOG" id="arCOG01257">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008891_7_3_2"/>
    <dbReference type="OrthoDB" id="9362at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03343">
        <property type="entry name" value="cpn60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012714">
        <property type="entry name" value="Thermosome_arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02339">
        <property type="entry name" value="thermosome_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF85157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="556" mass="59569" checksum="BC090E68FB2D2A6D" modified="2014-10-29" version="1">MASIQTTPGGMPVLILKEGTKESKGREAQKNNLTAAKLIAEIVKTSLGPRGMDKMLVDNLGDVTITNDGATILKEIDVQHPAAKMMVEVSKSVDNEVGDGTTSSVVFAGALLEKAEDLLNKDVHPSVIVDGYNAAADQALKLLEKMAVQVDVSDKDMLLKIARTSMDSKLVSDDSPLLGAMVADAAKQVAEKTENGALKVDLDNIKVEKKAGGSMRDTKLIKGIVLDKEVVHAGMPKRIEGAKIALVNSALEIEKTEMSAEIRISDPHQMQMFLEEENRMLKAMVDKVKSSGANVVLCQKGIDDIAQHYLAKAGVLAVRRVKESDMTKMSRATGARIVNNLDDLTAKDLGSAELVEERKVETDKWVFIEGCKNPKAVTILIRGGSQRVVDEADRSLHDALMVMKDVLEKPAIVAGGGAPEAYIANELRQWSSSQEGRAQLAVQKFADALDTIPLNLAENAGMDPIDTMTELRAKQSKGSKWTGVDARNTVVADMYKQNVLEPLVVKQQIIKSATEVASMILRIDDVIAASKSKMPAMPPGGGGMGGMGGMGGMGME</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWZ9</accession>
    <name>A0A075MWZ9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ring-cleavage extradiol dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_01743</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWZ9"/>
    <dbReference type="STRING" id="1459636.NTE_01743"/>
    <dbReference type="KEGG" id="nev:NTE_01743"/>
    <dbReference type="eggNOG" id="arCOG03101">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099500_2_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050383">
        <property type="entry name" value="GlyoxalaseI/FosfomycinResist"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21366">
        <property type="entry name" value="GLYOXALASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21366:SF22">
        <property type="entry name" value="VOC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="31"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF83804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="158" mass="18036" checksum="39970ECDB2E9D28C" modified="2014-10-29" version="1">MKQNSNSRKKSSNRQRSNNKDIKNDKMKVRKVIETCIYSHDLGSLKKFYSDILGLKVVDEEEGKFVFLKAGASMLLVFNSDRTFPSNDKLPPHGAYGNIHFALEIETGDYEKWKEHLAQNGVAIELEVNWKEARSLYFRDPSGNLVELITPGAWPVDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MX53</accession>
    <name>A0A075MX53_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoside-diphosphate-sugar pyrophosphorylase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01813</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MX53"/>
    <dbReference type="STRING" id="1459636.NTE_01813"/>
    <dbReference type="KEGG" id="nev:NTE_01813"/>
    <dbReference type="eggNOG" id="arCOG00663">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029499_2_2_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd04181">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050486">
        <property type="entry name" value="Mannose-1P_guanyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22572">
        <property type="entry name" value="SUGAR-1-PHOSPHATE GUANYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="1">
        <location>
            <begin position="15"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="241" mass="26560" checksum="072CA8F36E243273" modified="2014-10-29" version="1">MITFYTIVQEFWVMKAVILAGGFGKRLKPLTDQIPKPMIEVLNLPIIEWQIKWLAGNGIKEFIICVGYLKEQIINHIGSGSRLGVKVGYAVEEEPLGTGGALKNAEGLLSGQSEFFMLNGDILSNLDPLKLRDGGAAHALALVPLRSPYGVVEVDKANKVLGFVEKPRIKDRWINAGVYHFTSDVFSYLPENGNIETTALPALAKEGKLKATTYDSIFWRSIDSHKDIEEAAKEMQAANIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MX62</accession>
    <name>A0A075MX62_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03182</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MX62"/>
    <dbReference type="KEGG" id="nev:NTE_03182"/>
    <dbReference type="HOGENOM" id="CLU_3178400_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="46" mass="5258" checksum="B726B005C0DA12A8" modified="2014-10-29" version="1">MVVFADPFPFHVAKPVDLDIVLLYFAASAHFARRENPYVIEIADHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MXG1</accession>
    <name>A0A075MXG1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700654.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MXG1"/>
    <dbReference type="STRING" id="1459636.NTE_01935"/>
    <dbReference type="GeneID" id="41597684"/>
    <dbReference type="KEGG" id="nev:NTE_01935"/>
    <dbReference type="HOGENOM" id="CLU_2165353_0_0_2"/>
    <dbReference type="OrthoDB" id="372648at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="110" mass="12033" checksum="82BB268A486290D3" modified="2014-10-29" version="1">MSNQNIFQAFEEAKKASGKFLKLAPGERRTLQFNVNKIEIADSEFEGKKTGGKSIHFTVIDPKEPQAEKVLSMGVKKADAIMALLKAGKNLLDIQKIGSGKDSQFIAIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MXZ7</accession>
    <name>A0A075MXZ7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03489</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385687.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MXZ7"/>
    <dbReference type="GeneID" id="43502686"/>
    <dbReference type="KEGG" id="nev:NTE_03489"/>
    <dbReference type="HOGENOM" id="CLU_3130672_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="49" mass="5768" checksum="496A791AD4536819" modified="2014-10-29" version="1">MMWFNNQYGYVYLMNHAVNPSSYKVTKIVIEGWISMGYQCVIEKIDKAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MY43</accession>
    <name>A0A075MY43_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">3,4-dihydroxy-2-butanone 4-phosphate synthase</fullName>
            <shortName evidence="6">DHBP synthase</shortName>
            <ecNumber evidence="6">4.1.99.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NTE_03549</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18457"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="4.1.99.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Binds 2 divalent metal cations per subunit. Magnesium or manganese.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; riboflavin biosynthesis; 2-hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DHBP synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.12" evidence="6"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701948.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MY43"/>
    <dbReference type="STRING" id="1459636.NTE_03549"/>
    <dbReference type="GeneID" id="41599167"/>
    <dbReference type="KEGG" id="nev:NTE_03549"/>
    <dbReference type="eggNOG" id="arCOG01320">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020273_3_2_2"/>
    <dbReference type="OrthoDB" id="25735at2157"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008686">
        <property type="term" value="F:3,4-dihydroxy-2-butanone-4-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.10">
        <property type="entry name" value="DHBP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000422">
        <property type="entry name" value="DHBP_synthase_RibB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00506">
        <property type="entry name" value="ribB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327:SF46">
        <property type="entry name" value="3,4-DIHYDROXY-2-BUTANONE 4-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327">
        <property type="entry name" value="GTP CYCLOHYDROLASE II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00926">
        <property type="entry name" value="DHBP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="YrdC/RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 6" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0686">Riboflavin biosynthesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF85577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="229" mass="24866" checksum="4837AA23522EC7F8" modified="2014-10-29" version="1">MPLTEAIEALKAGRFVLVHDDKGRENEVDMVVAAEHVTPAHIAAMRQDAGGLLCLAIANEVTSKLGLVYMHDMIASMGKVNPVFSKLVEGRAAYGDKPSFSISVNHRDTFTGITDQDRALTISEMAKVCKRIDNGGVEDFARNFRAPGHVPVLIAAKNLLSDRNGHTELCVYLMKLANMTPAVAICEMMDSQTHRALSVEKALAYARKSGIPLVEASELKEAHQRAKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MYH1</accession>
    <name>A0A075MYH1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Farnesyl-diphosphate synthase /geranylgeranyl-diphosphate synthase</fullName>
            <ecNumber evidence="7">2.5.1.1</ecNumber>
            <ecNumber evidence="7">2.5.1.10</ecNumber>
            <ecNumber evidence="7">2.5.1.29</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NTE_02265</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.1" evidence="7"/>
    <dbReference type="EC" id="2.5.1.10" evidence="7"/>
    <dbReference type="EC" id="2.5.1.29" evidence="7"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226986952.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MYH1"/>
    <dbReference type="STRING" id="1459636.NTE_02265"/>
    <dbReference type="GeneID" id="41597980"/>
    <dbReference type="KEGG" id="nev:NTE_02265"/>
    <dbReference type="eggNOG" id="arCOG01726">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014015_2_1_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004337">
        <property type="term" value="F:(2E,6E)-farnesyl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004161">
        <property type="term" value="F:dimethylallyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004311">
        <property type="term" value="F:geranylgeranyl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43281">
        <property type="entry name" value="FARNESYL DIPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43281:SF1">
        <property type="entry name" value="FARNESYL DIPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01017">
        <property type="entry name" value="Polyprenyl_Transferase_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF84319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="335" mass="36016" checksum="A4377C1CA648FB11" modified="2014-10-29" version="1">MKASSMKNELDSCAFVVNEFLLSQLDGKPKALYQASSHYIRSGGKRLRPFMVIKSCELLGGVVKRALPAAGAVELVHNFTLVHDDIMDNDEMRHGVATVHHQYGLPLAILGGDILFSKAFEILSYSGRKVGIGEKEITEMVGRLANSCTVICEGQTIDIDFASNTKFPSESQYIDMIGKKTAALFEVSCAMGALSSPNPSSKDVDSLASFGRNIGVAFQLVDDLIGAIGDPKVTGKAAGNDIREGKKTLPILLALRKAKGDERDKLMKVFGSKAASAQEIKDAVKVVSDMGIDEDVRNAARQHMAKALGSIEGYSNADARRSLQFAADFIVGRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MZ41</accession>
    <name>A0A075MZ41_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701079.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MZ41"/>
    <dbReference type="STRING" id="1459636.NTE_02470"/>
    <dbReference type="GeneID" id="41598176"/>
    <dbReference type="KEGG" id="nev:NTE_02470"/>
    <dbReference type="HOGENOM" id="CLU_1965632_0_0_2"/>
    <dbReference type="OrthoDB" id="10077at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="129" mass="13832" checksum="B912D89DE4A997F1" modified="2014-10-29" version="1">MSASSESLDAILQLPQRKLVVAQSEVHLNKPAKNEIFVLMIEESRGSAGGRAAGSGHRKIGKVYGFACEGGKCDKLYEVDDPAKVEMFDIPYSAVAMDIVLSTGQPYVVQGIVDPEFVANYKGIAGNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MZ46</accession>
    <name>A0A075MZ46_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Electron transfer flavoprotein alpha subunit apoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_02475</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ETF alpha-subunit/FixB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701083.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MZ46"/>
    <dbReference type="STRING" id="1459636.NTE_02475"/>
    <dbReference type="GeneID" id="41598180"/>
    <dbReference type="KEGG" id="nev:NTE_02475"/>
    <dbReference type="eggNOG" id="arCOG00448">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034178_1_1_2"/>
    <dbReference type="OrthoDB" id="7021at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001308">
        <property type="entry name" value="ETF_a/FixB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014731">
        <property type="entry name" value="ETF_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153:SF1">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00766">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Electron transfer flavoprotein alpha/beta-subunit N-terminal" evidence="2">
        <location>
            <begin position="6"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF84524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="392" mass="43567" checksum="18925AB6A53C3741" modified="2014-10-29" version="1">MKYEHLYVVIEHEEGEPVPVSLEMLGEARRLMDGYNKKYSANEKVVAIVLGSGVRAICDELVQYGADAVIYADSPELKYSRNLVDTKVISQIALDKSLVAKFADSSPDFVRPRYMFFAADSIGRQLSSTVMAQLDSGLASDINKLVIADLEIRHEHKTKGQQMVYERTLEMYRPDFSGFLWTTILCLDNRNPAIARDYHPQACSIIPGVFEPIERDTSRKGVIVDYSPTFDPDDLKVKVLSRTPVKSAVDYDSKKAVVSFGRGIKDAPEQNIKLMVDLAKELDAEVGVSLPISKKPYPVSEGISSSYMIPDRVIGTSGRKVMPLLYIAAGISGAMQHIAGMKESGFVIAINPDVESPIKDECDMFIKGRMEDVIPVLIEELRAIRPALEARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MZE9</accession>
    <name>A0A075MZE9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative Zn-dependent protease-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_02580</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701162.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MZE9"/>
    <dbReference type="STRING" id="1459636.NTE_02580"/>
    <dbReference type="GeneID" id="41598274"/>
    <dbReference type="KEGG" id="nev:NTE_02580"/>
    <dbReference type="eggNOG" id="arCOG00322">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026425_4_2_2"/>
    <dbReference type="OrthoDB" id="84520at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2290.10">
        <property type="entry name" value="PmbA/TldD superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045569">
        <property type="entry name" value="Metalloprtase-TldD/E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045570">
        <property type="entry name" value="Metalloprtase-TldD/E_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002510">
        <property type="entry name" value="Metalloprtase-TldD/E_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047657">
        <property type="entry name" value="PmbA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035068">
        <property type="entry name" value="TldD/PmbA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036059">
        <property type="entry name" value="TldD/PmbA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43421">
        <property type="entry name" value="METALLOPROTEASE PMBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43421:SF1">
        <property type="entry name" value="METALLOPROTEASE PMBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01523">
        <property type="entry name" value="PmbA_TldD_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19290">
        <property type="entry name" value="PmbA_TldD_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19289">
        <property type="entry name" value="PmbA_TldD_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111283">
        <property type="entry name" value="Putative modulator of DNA gyrase, PmbA/TldD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metalloprotease TldD/E N-terminal" evidence="1">
        <location>
            <begin position="20"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Metalloprotease TldD/E central" evidence="3">
        <location>
            <begin position="113"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Metalloprotease TldD/E C-terminal" evidence="2">
        <location>
            <begin position="228"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF84624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="443" mass="47178" checksum="67A388787F97666B" modified="2014-10-29" version="1">MESLLRLALKEAEAHGASDAEVYAAVTKESEVFIENNDLKQAKTQKASAVGIRVFLNGALGFYSVNSLDPDKIRNAVYSAVKIARVSPRDKLNFLPAKSKVGRVRGIYDRNAESFEAREAAKLAAEMLKTAKSHDKKVSVDSGNFSATGMTHWLANTNGVLLSEKLSVFSWSIMGMAIDGDDVSSFDVQSGGTHHVKDIEVHTAASEFARTVAGSLGAKKMTDSFKGEMLLTPAAAMEMVEEVVAHSINSDAVQKKSSMFAGKLGKRVASAMLAVEDDATNADGLAAASFDREGVPHRKNVVIENGVLKKFLYNTYTAKKAGTRSTGNASGSTSSPPSVATTNFAVKPGKSSLDGLISEIKQGVMISRFSGNVNPVNGDFSGVVKGGWLVRNGELVHPVKEVMVAGNVFDCLKNLTGLSKERKVIGASILPYMRFGRVSFTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N234</accession>
    <name>A0A075N234_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Trk-type K+ transport system, membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NTE_03481</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TrkH potassium transport family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701900.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N234"/>
    <dbReference type="STRING" id="1459636.NTE_03481"/>
    <dbReference type="GeneID" id="41599110"/>
    <dbReference type="KEGG" id="nev:NTE_03481"/>
    <dbReference type="eggNOG" id="arCOG00606">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG04145">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_451740_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32024">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN TRKG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32024:SF2">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN TRKG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="151"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="487"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="595"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="652"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="13"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="78"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIF85509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="678" mass="74373" checksum="BC288AD84485454F" modified="2014-10-29" version="1">MQDVLERPVTSYMHRLFVTLDENTNVARAVQQMNSQSAETIIVSSNARPAGIVTDSDILDQVVMKGEDSDQVFLKTVMSKPLVTISPKGTVRQALQLMRINQVKRLPVVVNGTEVLGIVTQVALANAVRTSVLERTFGRYRSMITEKYKPILGNLGILLQFSGVLLVVPAFLGAALGENTSIVGILFAVIGLSFAGFFLTHVGEKSPMNLKQASIFIVSSFVLLSLFGSIPYMYLDPFQRNLDWPSLFVDSFFESASGFTTTGLSLISNPESLPKSLDFYHSYTQWVGGLSFVYLVMILFFPERKLSAMKSVLGGGMLRVKELLVTIVVIFTAYTVLLIFATVFFSQTDVLDATSLVFSTITSGGFIPDSGIINPQHPERMAFVSVGMILSALPFAFHYYIFSKAGLRTRKTITLEVGVFFLLMAVSIPIFFMLAGGFVDNGSAITGDDNRSEKVDIYSAAFHVISGTTTTGFQYLDIHSTSSTAKVFLIVIMLVGGTAFSTAGGIKVGRFVILYQEFRKHAREKVGGNAAVAGSSTSTSISSTANPYRSSEFITRIREDHQRGQIEDKIDDQEKTTTLLRQTRLIVGKKVVREILVIIALYVCISFLTGLAISFFTGSKFEDSLFESVSAISTTGLTAGVTSVNLDSFSKLMLTLNMVVGRFEIIALLYIFFSYFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N2A1</accession>
    <name>A0A075N2A1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987071.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N2A1"/>
    <dbReference type="STRING" id="1459636.NTE_03541"/>
    <dbReference type="GeneID" id="41599159"/>
    <dbReference type="KEGG" id="nev:NTE_03541"/>
    <dbReference type="eggNOG" id="arCOG11425">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_158387_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="128" mass="14520" checksum="719557EF2A142738" modified="2014-10-29" version="1">MSSNDDLSEPRKSILDLLDEFIEQIQRIRKVMLGVSISAIVLAPLAIGLSAYLLLHPSFFAVLDIENDFGLVLSTLLGAVNAISLIWLVTGIRQYYSINTWKKRYAEYQKEKEEIDRKIASQFGLDQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MKZ5</accession>
    <name>A0A075MKZ5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MKZ5"/>
    <dbReference type="KEGG" id="nev:NTE_00027"/>
    <dbReference type="HOGENOM" id="CLU_1623388_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="163" mass="17685" checksum="FA6C5D40B9B15E8F" modified="2014-10-29" version="1">MTEASSNDDDGSSSSSMAIPVIVGLVVGAAFIMVFASSIFNSFEQKVTAKQNGVTISVVGLKTRYSAGEALNFAVTAKGYGKVCSPVIARIVNVNSGDEVEHFSKNFPNCNLTERKIDEKWTLHDIEGDSYFPLLVQQLHGSGHYRLIVGYRGATLEEDFIQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ML13</accession>
    <name>A0A075ML13_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphate-specific transport system accessory protein PhoU</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_00042</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in the regulation of phosphate uptake.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PhoU family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699191.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ML13"/>
    <dbReference type="STRING" id="1459636.NTE_00042"/>
    <dbReference type="GeneID" id="41595994"/>
    <dbReference type="KEGG" id="nev:NTE_00042"/>
    <dbReference type="eggNOG" id="arCOG00232">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078518_3_2_2"/>
    <dbReference type="OrthoDB" id="7738at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:intracellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045936">
        <property type="term" value="P:negative regulation of phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="entry name" value="Phosphate transport system protein phou homolog 2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028366">
        <property type="entry name" value="PhoU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026022">
        <property type="entry name" value="PhoU_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42930">
        <property type="entry name" value="PHOSPHATE-SPECIFIC TRANSPORT SYSTEM ACCESSORY PROTEIN PHOU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42930:SF3">
        <property type="entry name" value="PHOSPHATE-SPECIFIC TRANSPORT SYSTEM ACCESSORY PROTEIN PHOU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01895">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003107">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109755">
        <property type="entry name" value="PhoU-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PhoU" evidence="2">
        <location>
            <begin position="16"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="PhoU" evidence="2">
        <location>
            <begin position="120"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR003107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF82126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="222" mass="25283" checksum="C8564FB2CFCE6DBE" modified="2014-10-29" version="1">MTRLLDYGLRSMSNLIMDMAELSVRSVDTAIELYEKGDGSSDRSQKIFEWSEQLRVLQDEVTELAVELIARYQPVATDLRFIRSCIEISYGFSRFGRYAYDIVDVMGMMGSVSHCDKGAVMEMADTARKMIHASVQALKSRDKEAAQKLYQMDDTVDALYRKYVREAITPSTKKGSNDLVKDPRCYVSSLLILRYLERIADHACYIGDSVYYIVTGTSSPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLA5</accession>
    <name>A0A075MLA5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ferritin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_00119</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699242.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLA5"/>
    <dbReference type="STRING" id="1459636.NTE_00119"/>
    <dbReference type="GeneID" id="41596059"/>
    <dbReference type="KEGG" id="nev:NTE_00119"/>
    <dbReference type="eggNOG" id="arCOG01093">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104506_4_0_2"/>
    <dbReference type="OrthoDB" id="5651at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01052">
        <property type="entry name" value="DPSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053475">
        <property type="entry name" value="DPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014490">
        <property type="entry name" value="Dps-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033921">
        <property type="entry name" value="DPSL_diiron-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040955">
        <property type="entry name" value="Arch_DPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009990">
        <property type="entry name" value="PRK13456.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30295">
        <property type="entry name" value="BACTERIOFERRITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30295:SF1">
        <property type="entry name" value="DNA PROTECTION DURING STARVATION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018063">
        <property type="entry name" value="Ferrtn_UCP018063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0409">Iron storage</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin/DPS" evidence="4">
        <location>
            <begin position="38"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR018063-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF82201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="201" mass="22766" checksum="1D12A525D4349EAD" modified="2014-10-29" version="1">MSDAEYAKTTKPVPNIVALEVLKKNGVNVDKLKDLIVKGVGAEFTTYYYYTILRMHCTGLEGEGIKEIVEDARIEDRNHFEAMVPRLYELGGALPRDIRRFADQAGCPDAFLPNNWEDINSILKVLLEAEQCAIRSWGEVCDMTAGKDPRTYDIAQRIMQEEVEHEAWFIELLSKRPSGHFRRKFAGQSPHTGAQGSLIHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLM7</accession>
    <name>A0A075MLM7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ParB-like partition protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_00304</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ParB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699381.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLM7"/>
    <dbReference type="GeneID" id="41596209"/>
    <dbReference type="KEGG" id="nev:NTE_00304"/>
    <dbReference type="eggNOG" id="arCOG07935">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023853_0_1_2"/>
    <dbReference type="OrthoDB" id="11840at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16396">
        <property type="entry name" value="Noc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2830:FF:000001">
        <property type="entry name" value="Chromosome partitioning protein ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2830">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1530.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050336">
        <property type="entry name" value="Chromosome_partition/occlusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041468">
        <property type="entry name" value="HTH_ParB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004437">
        <property type="entry name" value="ParB/RepB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00180">
        <property type="entry name" value="parB_part"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33375">
        <property type="entry name" value="CHROMOSOME-PARTITIONING PROTEIN PARB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33375:SF1">
        <property type="entry name" value="CHROMOSOME-PARTITIONING PROTEIN PARB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17762">
        <property type="entry name" value="HTH_ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109709">
        <property type="entry name" value="KorB DNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="ParB/Sulfiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB-like N-terminal" evidence="3">
        <location>
            <begin position="27"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF82386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="345" mass="39437" checksum="908C0171E5206B75" modified="2014-10-29" version="1">MNERNATDLGAGVASTGDTEEQRGLIQYIKASSIKFSALLLRPHDDKEIMQLSKSIKEVGLLQPIIVRLKDGFYEIVAGNRRFTACKALGWRKIPCYVLDLDDKAMFEMALIENVQRKTMTPLEEAESFRRYVEEKGWGSVAELASRIGKSSAYISKRIALLDLPTDVRDRIANNEIFPSAAEEILTIKDKEKQSELANMIAARRLTIKKARLLVDQLKKKESLVGNNSSSIVDTILVNDMIMAGSNTYSPQQQECEYDDISQQLNQITTKGYDHLTIKYHKAFDRAIVASKICMNNMDDVLKDVEENWLVYELLLQQRTTIHSIIDLLQKEKRNLRRARLFRYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLS7</accession>
    <name>A0A075MLS7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00369</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLS7"/>
    <dbReference type="KEGG" id="nev:NTE_00369"/>
    <dbReference type="HOGENOM" id="CLU_1375468_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="198" mass="21894" checksum="B6F3D4DF5C089D48" modified="2014-10-29" version="1">MPQHFFVEKESSMVAPLPASCSSLSSSSSLSMSETERIDVRASKITISLSRMFETVIGYHLYIVYADNEGQEFIFEGLPFDPKTGKVPLFSPSTLFLNPSGLLTRGQCIASQWKRESSFYVPSALSVTVIAGAKASEKYRCLQEQTCAFNSANIPYYMTTGPNSNSYVRTMLERCRIPAIKPISAIPAPGWDLSIELH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLV6</accession>
    <name>A0A075MLV6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00404</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLV6"/>
    <dbReference type="KEGG" id="nev:NTE_00404"/>
    <dbReference type="HOGENOM" id="CLU_2930323_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="61" mass="7034" checksum="47F18FF840DA22B3" modified="2014-10-29" version="1">MMSAKLPQNIHDRALLTEHGIDRQFLSMLTDQQAQDLLKGILYLKEKHKHLLQSCTDLSCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLW0</accession>
    <name>A0A075MLW0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphate uptake regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699190.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLW0"/>
    <dbReference type="STRING" id="1459636.NTE_00041"/>
    <dbReference type="GeneID" id="41595993"/>
    <dbReference type="KEGG" id="nev:NTE_00041"/>
    <dbReference type="eggNOG" id="arCOG00318">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069302_1_0_2"/>
    <dbReference type="OrthoDB" id="40991at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:intracellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045936">
        <property type="term" value="P:negative regulation of phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="entry name" value="Phosphate transport system protein phou homolog 2, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028366">
        <property type="entry name" value="PhoU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026022">
        <property type="entry name" value="PhoU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42930">
        <property type="entry name" value="PHOSPHATE-SPECIFIC TRANSPORT SYSTEM ACCESSORY PROTEIN PHOU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42930:SF2">
        <property type="entry name" value="PHOU DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04014">
        <property type="entry name" value="MazE_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01895">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00966">
        <property type="entry name" value="SpoVT_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="AbrB/MazE/MraZ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109755">
        <property type="entry name" value="PhoU-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="1">
        <location>
            <begin position="27"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="365" mass="40392" checksum="E828CFB6F835286C" modified="2014-10-29" version="1">MRTTATTTTAAGSAAATDQKEVRKVQFTGRSTYVLSLPKRWIEEMHLHAGDQVTLVRETDNSLSIVPTNTGPAESLAEATAIITSSSSEGESSLRRKVVSMYLAGYNIIHLKLKAGRINPALRDAVRDVVRRNLVGTEMIADASDIITLQVLLSLPELSVNTAIRRMYLIASSMHRDAMTALSELNLELAREVIKSDDEVDRFSLYVLRNLVMATQNGRVLREMGLKSPSDCLSYRVAVKSIERVADHACGIAEMAAKLKDKIPRETLQKIEKMSYLALTVLGDSVEALLRRDYQLADKTVDQVEGIHALEQEALGFVEKSRDPASLKLVLEDIRRTAEYASDIAEAALNETIEEVIERSNIQHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MM09</accession>
    <name>A0A075MM09_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MEDS: MEthanogen/methylotroph, DcmR Sensory domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MM09"/>
    <dbReference type="KEGG" id="nev:NTE_00196"/>
    <dbReference type="eggNOG" id="arCOG01171">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1492921_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025847">
        <property type="entry name" value="MEDS_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14417">
        <property type="entry name" value="MEDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MEDS" evidence="1">
        <location>
            <begin position="14"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="180" mass="20827" checksum="A0F886D9AA3A1C58" modified="2014-10-29" version="1">MILKQLEKTKHGEHNIVIYPSTSALNDVMTVHYKEALEARNELALFVTTYTHPDKVRKILGQSGLDVAKYEDEGSLVIYDAVKGYQSTEGVYTVMALINMLFEKAAKLGKTGMFGMADMGSFFVYEAIEKLMSYELSLPSVWDKMKLRSFCLYHRRDFYSLLPEERQALIEHHYKYIRAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MM51</accession>
    <name>A0A075MM51_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MM51"/>
    <dbReference type="STRING" id="1459636.NTE_00113"/>
    <dbReference type="KEGG" id="nev:NTE_00113"/>
    <dbReference type="HOGENOM" id="CLU_3322767_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="38" mass="4238" checksum="F882C03692C6941F" modified="2014-10-29" version="1">MDLLEAVMWVALSFFVTLAGLEVAWSEVGLKKKEEAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MM66</accession>
    <name>A0A075MM66_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phage tail sheath protein FI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_00495</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the myoviridae tail sheath protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699523.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MM66"/>
    <dbReference type="STRING" id="1459636.NTE_00495"/>
    <dbReference type="GeneID" id="41596368"/>
    <dbReference type="KEGG" id="nev:NTE_00495"/>
    <dbReference type="eggNOG" id="arCOG11414">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009303_1_0_2"/>
    <dbReference type="OrthoDB" id="275511at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11780">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035089">
        <property type="entry name" value="Phage_sheath_subtilisin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020287">
        <property type="entry name" value="Tail_sheath_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052042">
        <property type="entry name" value="Tail_sheath_structural"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35861">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35861:SF1">
        <property type="entry name" value="PHAGE TAIL SHEATH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04984">
        <property type="entry name" value="Phage_sheath_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17482">
        <property type="entry name" value="Phage_sheath_1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tail sheath protein subtilisin-like" evidence="2">
        <location>
            <begin position="235"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="Tail sheath protein C-terminal" evidence="3">
        <location>
            <begin position="409"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF82576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="521" mass="57111" checksum="753063F69E21222A" modified="2014-10-29" version="1">MPTNPTYPGVYIEELENPVKTIVGVSTSVTAFVGRALAGPTNKPVLIHNFGEFESIFGGLWKESTMSYAVYQYFLNGGMDAVIVRVFKAQTGSDEDKSKARFAAGSITFEATSPGVWANDYKLKIDDKVDASRNVPSPHLFNLHILDDAGVEQETFLNISINTGDPRFVKTVLDEESDLLRVSKDNPPINALPSMSDNIVSDKKGDDGVAVTNAELKGENTNDHKTGIYALDKADIFNLLCIPPPSPDGTTAPAFYSEVYATAAKYCQDKRAVLIMDPPSNWNSRDDPISGSIGIDSNTSGLFRHENAAIYFPRIRAPDPNQEGRLKDFAPCGAIAGVMARTDAQRGIWKAPAGIDAGLLGVPDLTVRLTDLENGSINQQGINCLRILPPAGRVVWGARTTKGADNLANQWKYLPVRRTALYIEETLYRNTKWAVFEPNDEPLWSQLRLSIGSFMHDLFRKGAFQGSTPKEAYLVKCDRETTTQYDIDRGIVNILVGFAALKPAEFVIIKIQQLAGQAEVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMU1</accession>
    <name>A0A075MMU1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158384857.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMU1"/>
    <dbReference type="STRING" id="1459636.NTE_00073"/>
    <dbReference type="GeneID" id="43502533"/>
    <dbReference type="KEGG" id="nev:NTE_00073"/>
    <dbReference type="HOGENOM" id="CLU_3075134_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="52" mass="5632" checksum="7250B92189B513DD" modified="2014-10-29" version="1">MLEALFAQMPCEQPACNAYDAAIKIAYAVIVTAAIIAIMAYVRKKRSDAALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMV1</accession>
    <name>A0A075MMV1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative xylanase/chitin deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_00403</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMV1"/>
    <dbReference type="STRING" id="1459636.NTE_00403"/>
    <dbReference type="KEGG" id="nev:NTE_00403"/>
    <dbReference type="eggNOG" id="arCOG02876">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_513525_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17957">
        <property type="entry name" value="Big_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0858">Xylan degradation</keyword>
    <feature type="domain" description="NodB homology" evidence="2">
        <location>
            <begin position="187"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="161"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF82485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="530" mass="57683" checksum="B4BB7EE40E2AA314" modified="2014-10-29" version="1">MSSRPILSSFALKFLSPLTTLVKSAPFSRVLGSRRLLAFAMFALIAMSAAMPSAFAQRPADKNLDRAGNVVHKVVGSALGSVADIAKMHDNGHDHSNNDDDNRTDRHDDERDDDGSRHSGGRNSSNSDDDDNGGGNDDRGRRGNNDDDDDNNNDDRDRDSSTNNSSSGNGSNDGGGSSSGNDGDRCNCIVMRLDDVQDEWVRDVQLALLNRLISNHVHTSTAIIMKDFGNDSAIVSKVREGGDAGLFEYSIHGWDHVDYATLSLEEQKSTLEKAKAKLVDVLGKDSDIFVTPYNNFSENTLSAMDQLGMTIISSDETDLFPAAPKESPLYPNIAHMPQTINFAEQVGEVKVLRPLNEIVSAVSADIRDKGYAVLTLHPQDFTQYKGTEVQNEVNPVAMLRLEQFIKSARDAGFSFAGFEQALEDNHPDLSTIPDKSKPYESVLTPSPGSSFSVNSEVTVTGRAFDDTAIKSVEVRTTDSSYRAASTDNNFEDWTETVQMPSAPGTVDIIAKATDIEGKQTWVYVPVNVTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MN59</accession>
    <name>A0A075MN59_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00504</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699532.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MN59"/>
    <dbReference type="STRING" id="1459636.NTE_00504"/>
    <dbReference type="GeneID" id="41596377"/>
    <dbReference type="KEGG" id="nev:NTE_00504"/>
    <dbReference type="HOGENOM" id="CLU_146747_0_0_2"/>
    <dbReference type="OrthoDB" id="384594at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="95" mass="10990" checksum="2E42C7E6DF568DC6" modified="2014-10-29" version="1">MFQPTSRYYNIEDASLAKDGNVVAYKKRRFLPKGEEMPLLQALTVSAGDRLDRISSRVFGDPEQFWQICDANDAMHPLDLTEEPGFMLRIARPWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MN62</accession>
    <name>A0A075MN62_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative membrane-associated Zn-dependent protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NTE_00613</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699613.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MN62"/>
    <dbReference type="STRING" id="1459636.NTE_00613"/>
    <dbReference type="GeneID" id="41596476"/>
    <dbReference type="KEGG" id="nev:NTE_00613"/>
    <dbReference type="eggNOG" id="arCOG00609">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028221_0_1_2"/>
    <dbReference type="OrthoDB" id="19110at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06160">
        <property type="entry name" value="S2P-M50_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044838">
        <property type="entry name" value="EGY1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31412">
        <property type="entry name" value="ZINC METALLOPROTEASE EGY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31412:SF0">
        <property type="entry name" value="ZINC METALLOPROTEASE EGY1, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 10" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="321"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M50" evidence="9">
        <location>
            <begin position="151"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIF82693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="390" mass="42426" checksum="930C092D4A6770BA" modified="2014-10-29" version="1">MASFVGGDFSQAVPVVSSFYSIVDMQKHQTEDAVRFLIAESDIYSSFPKLIRELAKVDMIATAKRTRYASRLMPSLSSTNLTVEDGVVITVSKLQKQQRKQGKNRYLLSLPAVLFIATLTVVFIDGLYRSQSDFARMFIHNPLLLAAVYTMSLVGILGVHEMGHMIAAKHHGIRASWPYFIPGIPGLFVPTFGAMIAIRSNMTNRNVLFDVGIAGPIAGLLVTMIVSVYGSSISVLVPADRMQDFGNSGLMPINSSILMQATLNLTGHGAAAGDAVLIMSPVLFAAWVGFLVTFLNLLPAWQLDGGHLARSALGVRWHRILTYSSVGILVGLNYYIMAAFILLFSSRAPESTPLDDVSPLSKKRKMLFWMAIALAVLCAPLPAQVFSPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MN72</accession>
    <name>A0A075MN72_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MN72"/>
    <dbReference type="KEGG" id="nev:NTE_00910"/>
    <dbReference type="HOGENOM" id="CLU_2985483_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="57" mass="6490" checksum="CB98A0DD50F67FC8" modified="2014-10-29" version="1">MAINQALTSMKSCKLNGRYGSKDCNPVVFRGITKKYRTAVYRCESKENLNQRCDLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MN77</accession>
    <name>A0A075MN77_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">tRNA (guanine(26)-N(2))-dimethyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.216</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NTE_00628</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.216" evidence="7"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699624.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MN77"/>
    <dbReference type="STRING" id="1459636.NTE_00628"/>
    <dbReference type="GeneID" id="41596491"/>
    <dbReference type="KEGG" id="nev:NTE_00628"/>
    <dbReference type="eggNOG" id="arCOG01219">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010862_5_1_2"/>
    <dbReference type="OrthoDB" id="372177at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160104">
        <property type="term" value="F:tRNA (guanine(26)-N2)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002940">
        <property type="term" value="P:tRNA N2-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.70">
        <property type="entry name" value="N2,N2-dimethylguanosine tRNA methyltransferase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002905">
        <property type="entry name" value="Trm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042296">
        <property type="entry name" value="tRNA_met_Trm1_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00308">
        <property type="entry name" value="TRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10631">
        <property type="entry name" value="N 2 ,N 2 -DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10631:SF3">
        <property type="entry name" value="TRNA (GUANINE(26)-N(2))-DIMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02005">
        <property type="entry name" value="TRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51626">
        <property type="entry name" value="SAM_MT_TRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 8 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="1 8" id="KW-0820">tRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF82708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="379" mass="42024" checksum="172EE6E0146B9FBB" modified="2014-10-29" version="1">MDGFVETVEGRTRLLVPALSLTERVPPKVPAFFNPAAKQSRDLSILAYRAFAPRLKEKTLADGFTGIGARALRVAVEVPEIEQVFANDANPTAIEAAKRSAELNGVSEKCRFSINEVCKFLMKGNDSEERFGIVDLDPFGTPARHVDCVLRAALDDGLVSITATDTAVLCGVYPKVCLRRYYGRPLNNSYGNETALRLLTSLIALTASRLELAIKPVFSHATMHYLRVYAQVSVSSSEANDVYANIGYVMHCFNCGNRLATREYDGTVKCELCQKKLRIGGQLWTGQLHEKEFVAKMKEQAGNDEKSKKVLDAALDEIDHVPYYFKADEISSKLRTNPHSIPKIIEKLQAAGYRASKTPLNFGAFKTDARLDRIIDVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MN80</accession>
    <name>A0A075MN80_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00529</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699548.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MN80"/>
    <dbReference type="GeneID" id="41596401"/>
    <dbReference type="KEGG" id="nev:NTE_00529"/>
    <dbReference type="HOGENOM" id="CLU_2340286_0_0_2"/>
    <dbReference type="OrthoDB" id="5850at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="97" mass="11184" checksum="BA49D5BFD9367581" modified="2014-10-29" version="1">MAKIRVYKRNSTFIDLSDLVERIGSIGLAETLKKYYNPPFEHEAKSIVAGPSFMQYLNRVFKTQIAAGDILQFESGDHDKYFMFSLTGTWDEIIKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MN89</accession>
    <name>A0A075MN89_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cation diffusion facilitator family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NTE_00935</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MN89"/>
    <dbReference type="STRING" id="1459636.NTE_00935"/>
    <dbReference type="KEGG" id="nev:NTE_00935"/>
    <dbReference type="eggNOG" id="arCOG01474">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013430_3_3_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="entry name" value="Cation efflux protein, cytoplasmic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050291">
        <property type="entry name" value="CDF_Transporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840:SF30">
        <property type="entry name" value="TRANSPORT PROTEIN, HYPOTHETICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="7">
        <location>
            <begin position="61"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="8">
        <location>
            <begin position="264"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF83011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="352" mass="38061" checksum="6C4A1F4B32B63196" modified="2014-10-29" version="1">MLQPFPTLKYDDLDSYLVKLLDDPFAVDVQHGSPTAAETARSSSSSSSMSEGLKAGQQIAKISVITLVAIGIVELVVGQISGSIVATADGIDSLSDAMISLIVFVGLYLATRPANKRFPFGYYKVESFAALLAAIGMVAIGAFILYHSYESFVNPHRIEQPVLTMVVLASAGGVSLHRALQMRKIARKYDLLSLKTDAKNSIKDGSASIIGFVSVLVASQFGFLQMDAIGGMIIAGYIFSVAYFSLRQSSLTLVDAWQNPGTSDKVKQLIESKFQAEPVKVRSVFLRPTGMMAHAEVHLEVDGDKKLQDFESLSFQVQSLIRSKFRLIDRISVIPHPLTFDGGGKKKGTTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MND2</accession>
    <name>A0A075MND2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Reduced coenzyme F420:NADP oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_00986</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MND2"/>
    <dbReference type="STRING" id="1459636.NTE_00986"/>
    <dbReference type="KEGG" id="nev:NTE_00986"/>
    <dbReference type="eggNOG" id="arCOG00457">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076368_1_1_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070967">
        <property type="term" value="F:coenzyme F420 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008823">
        <property type="term" value="F:cupric reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010185">
        <property type="entry name" value="NpdG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051267">
        <property type="entry name" value="STEAP_metalloreductase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01915">
        <property type="entry name" value="npdG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14239">
        <property type="entry name" value="DUDULIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14239:SF0">
        <property type="entry name" value="F420-DEPENDENT NADP REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase catalytic N-terminal" evidence="2">
        <location>
            <begin position="17"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF83061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="242" mass="26028" checksum="7164987DBF0A2822" modified="2014-10-29" version="1">MQSLKLISQDSVKVAMKIGIVGGTGGMGEGFAMRWCIKHDVMVGSRDAQKAKEAAANYRNAARQAYGPNVSIAGSITGDDNISLAKDSDILILSIPYEFIEDTCGKLASQVRPDCIIVSPIVPMTRTDNGFVYIPLLEQGKKTAGEWVADKMAPRSRVVSAFHTISEMKLKNVNLSLDADTFVCGDDPNVVAKLSELASEVAGLRPVYLGPLSLTYQAEVLTPMLLNAAKRNKLKNPGVKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNG0</accession>
    <name>A0A075MNG0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Theronine dehydrogenase-like Zn-dependent dehydrogenase</fullName>
            <ecNumber evidence="8">1.1.1.1</ecNumber>
            <ecNumber evidence="8">1.1.1.284</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NTE_00668</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.1" evidence="8"/>
    <dbReference type="EC" id="1.1.1.284" evidence="8"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699656.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNG0"/>
    <dbReference type="STRING" id="1459636.NTE_00668"/>
    <dbReference type="GeneID" id="41596527"/>
    <dbReference type="KEGG" id="nev:NTE_00668"/>
    <dbReference type="eggNOG" id="arCOG01459">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_3_2"/>
    <dbReference type="OrthoDB" id="9358at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051903">
        <property type="term" value="F:S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08283">
        <property type="entry name" value="FDH_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813:SF2">
        <property type="entry name" value="DEHYDROGENASE, ZINC-CONTAINING, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02810)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="7">
        <location>
            <begin position="27"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="6">
        <location>
            <begin position="188"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF82748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="375" mass="41655" checksum="66DC14436B8D6F20" modified="2014-10-29" version="1">MRAVVYHGPKDVQIDDDRPKPRIEHSEDIILKITKTAICGSDLHLYHGNIKGMEPGQVLGHEFAGIVEQVGDRVEEVKQGDRVVVPFNINCGRCWYCRHGLWSQCDRSNPQGELGAVFGYGQNMGGYDGGQAEYVRVPYANTVPLKIPENLSEEQALFLSDVFCTGYFGADMANVQPGDDVAVFGAGPVGYFAVVSAFLRGAARVFAIDHWPARLDKAKKAGAEPINFDQEDPISKIKQETKCRGAICIDAVGYEAVGHHLHDNSANPAYIPQDSLQVINWIVQAAKKFTTVGIPGVYLTEYADFPLGQFFQRELQIKMGQCPVKKYNEQLLHLIEVGRVDPTQLISHRMKLDEAPKAYDMFDKKEDVTKVVMTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNJ0</accession>
    <name>A0A075MNJ0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NTE_00688</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the HerA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699672.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNJ0"/>
    <dbReference type="STRING" id="1459636.NTE_00688"/>
    <dbReference type="GeneID" id="41596544"/>
    <dbReference type="KEGG" id="nev:NTE_00688"/>
    <dbReference type="eggNOG" id="arCOG00280">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023842_2_0_2"/>
    <dbReference type="OrthoDB" id="107033at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008571">
        <property type="entry name" value="HerA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002789">
        <property type="entry name" value="HerA_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42957">
        <property type="entry name" value="HELICASE MJ1565-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42957:SF1">
        <property type="entry name" value="HELICASE MJ1565-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01935">
        <property type="entry name" value="DUF87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase HerA central" evidence="5">
        <location>
            <begin position="146"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00048954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF82768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="530" mass="58874" checksum="2A45857C5738C166" modified="2014-10-29" version="1">MNDNDDNKNNYERAVIEELGILVGVAKPDQVTVEAKRPISIGEYVILKYGRGKVLGLVERSSIASDALGSHIRNYEEASESRLVAQANRHDKSYKANVRVLGYLDELKKCKAIIPALPPEPGTQVFEASPDDLRTIFAPEGPQWLRIGTLLRNTEVEARINIDKVVSRHLAVLAMTGMGKSNLVSMLAKEVAKVNGTMVIFDYHDDYSTLEMGRCINLMPAKINPRMLPADKLAEVIEIQENATNQIHVVRQALTEGVRQRKGDDFWDSLSAGVRDVGAEDKIYREAAAKVEDKIDYVRKKFGGILDPGMADPLALIKNGKINIINLVELTEKQANVSVSYYLEELLDDRKRATRQAKNKSPSQQDIKSPPRFTAPVLVVIEEAHIFIPKDEKTETKHFASKVAREGRKFGLGLVIVSQRPRSIDANILSQMGSLAVMRMIQQDDQMQVSAASEALSRDLIDQLPSLNPGEAVFAGQWVNLPAFVKADEVRERKIGGDQKAVEQWGMLAEAKEMAKESSDSYVPSGYIQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNM6</accession>
    <name>A0A075MNM6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699635.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNM6"/>
    <dbReference type="STRING" id="1459636.NTE_00640"/>
    <dbReference type="GeneID" id="41596503"/>
    <dbReference type="KEGG" id="nev:NTE_00640"/>
    <dbReference type="eggNOG" id="arCOG08703">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139543_0_0_2"/>
    <dbReference type="OrthoDB" id="6817at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="135" mass="15717" checksum="AE315D92B32D9CB9" modified="2014-10-29" version="1">MATSDPTGGDKVVYFGVININENGRTLGSVDIWRSLLTKEMFCEEKRLGILDIVDYIGMPKKKEEEEWAVAVSRKRKGHLRWRLVKLVKEGRFRFEDADEKLVEIEVKDYAIADPEWWSFLVKNNVNRNVEVEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNN7</accession>
    <name>A0A075MNN7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699646.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNN7"/>
    <dbReference type="STRING" id="1459636.NTE_00655"/>
    <dbReference type="GeneID" id="41596516"/>
    <dbReference type="KEGG" id="nev:NTE_00655"/>
    <dbReference type="HOGENOM" id="CLU_2204196_0_0_2"/>
    <dbReference type="OrthoDB" id="11683at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="110" mass="12167" checksum="860938C9FFC76A5D" modified="2014-10-29" version="1">MAAASAADSRTRDLVGQAQGVLAKADDPASLWRAYVAVEYAILDIKLRHGLEHEQSPPTAPKRTAKRDDLLAFAKEKLGRLDLEKGDRKKLLYELRECRDALKALLAKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNS4</accession>
    <name>A0A075MNS4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Roadblock/LAMTOR2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00785</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699750.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNS4"/>
    <dbReference type="STRING" id="1459636.NTE_00785"/>
    <dbReference type="GeneID" id="41596635"/>
    <dbReference type="KEGG" id="nev:NTE_00785"/>
    <dbReference type="eggNOG" id="arCOG08684">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128582_1_0_2"/>
    <dbReference type="OrthoDB" id="9657at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="134" mass="15268" checksum="D7B68ACF6580067C" modified="2014-10-29" version="1">MKQFFQDICDKVVSLDPAIRFAGIADEDGKLVATAERKGLKPLLTPEERAQYAITAATRQYTRLRWEYLLGKIDYASSHYAKLIRATIPIADENSRLYYVMLLSFDVNAGDKVHGIIMKKIIPLVRKNTGKFMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNY6</accession>
    <name>A0A075MNY6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mn2+-dependent serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00782</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNY6"/>
    <dbReference type="KEGG" id="nev:NTE_00782"/>
    <dbReference type="eggNOG" id="arCOG01186">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG07292">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_494028_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05403">
        <property type="entry name" value="NT_KNTase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041633">
        <property type="entry name" value="Polbeta"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18765">
        <property type="entry name" value="Polbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Polymerase beta nucleotidyltransferase" evidence="1">
        <location>
            <begin position="14"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="551" mass="61529" checksum="0027261AFB3744DC" modified="2014-10-29" version="1">MSSISPAELQVLQKCIDKIAKGRKVAAACIYGSKVAGYARPDSDIDVIVVLENYPYRVKYAYVKESGIDVSALVVNKKSLERDAKSARMGEFVAGRLLHVYEPMINPEFFAQVERIYKRRVILEELQELVKSSSVLATEISFPLEYIAFSKVKRRAAMYPNAAYSYFKTYNTTASPRNIDFAMQGYRRALADIVIEDPGLFIIDGPMLRLSGERVKFARGKPVLHLTKKLRHFISSYVVHSYAGRHMFHLAVKEAESKIRRHVSQHVEFPPFLACPACEYWKIPEGALVVVADRHSGGDWIDAVAQAHGISSGYSAKKRRLGNPNSRTMLYTLKHGGSELKIAAKELARTKSVKWAALSMWTAQVKKFKVDPMYRLGTEYRALRYLRTLGLKTPEIEAVVLDRRILATRFVEGTSLADIIRDALAGNSNDFGLVREAGRQVAVVHAQGACFGNIKPKNVIASDNELWFTDLEQFVFEGGDPVWDLAQFVCWGLKGSANAPVAAKVAAEFLKGYGNEQVAGRLAQSKRYIENFLPVLSPQVARAIKNVARSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MP16</accession>
    <name>A0A075MP16_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative flavoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00882</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385071.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MP16"/>
    <dbReference type="STRING" id="1459636.NTE_00882"/>
    <dbReference type="GeneID" id="41596722"/>
    <dbReference type="KEGG" id="nev:NTE_00882"/>
    <dbReference type="eggNOG" id="arCOG00509">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1544249_0_0_2"/>
    <dbReference type="OrthoDB" id="380767at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="1">
        <location>
            <begin position="20"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="188" mass="21121" checksum="60FE2D577582C47D" modified="2014-10-29" version="1">MKTASVTRKTRRRCERGTKAIILFDTLFGNTEKVGNSLVKGLREAGIEADCANITDTSIAKIANYDFIAIGAPTQFVTASKPIKQFLERLRALDLKGKYGFAFDTRLDDVMAGSAAEYIEKKLVTYGLEILRPHSSATVVWEEKKIEGEEKSRTQANIKPEMKQFFETIGRELGELLHAKEKKKSMQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MP31</accession>
    <name>A0A075MP31_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01209</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700073.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MP31"/>
    <dbReference type="GeneID" id="41597018"/>
    <dbReference type="KEGG" id="nev:NTE_01209"/>
    <dbReference type="HOGENOM" id="CLU_1514544_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="177" mass="19972" checksum="58D8F7B92CB01DA0" modified="2014-10-29" version="1">MAQITNPVEVDQSGRKFQYIQNNFANIGLQPNEERVVLDVKEKGEIFMYEMHGNSRHLGLSVDIWADSGAQISIMGGHLTFEKLLQKAWGLSAGEVAPVSGVSPDPHGEPNYRHPYLLRFKTTTEQDITGEDDERYSMAYTPNPYTAYGSRIRVTLVNHSNETGVVEDFVLTRKVWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MP65</accession>
    <name>A0A075MP65_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01262</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700118.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MP65"/>
    <dbReference type="STRING" id="1459636.NTE_01262"/>
    <dbReference type="GeneID" id="41597067"/>
    <dbReference type="KEGG" id="nev:NTE_01262"/>
    <dbReference type="HOGENOM" id="CLU_2091192_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="116" mass="13292" checksum="FB64181B8905F11D" modified="2014-10-29" version="1">MVEWDLNPRVLAAKASRQELVRLIIANGLTETLYLFYFLYMSIMGRDVVEATTKGDVIADLRSLGIEPRTRTELNDEKELEGLAEILKQSMIEDYKIAYSERGREYKEEASSTLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MP76</accession>
    <name>A0A075MP76_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00516</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MP76"/>
    <dbReference type="KEGG" id="nev:NTE_00516"/>
    <dbReference type="HOGENOM" id="CLU_1003266_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="277" mass="31079" checksum="C304C6C3D1B07BE3" modified="2014-10-29" version="1">MANHFWVGSLCLRAPPSPSFSSTTLTSVFSSIAARIKPPPSPSYPSNVIAVSDTLTILEDLGNHIPDKSWMLYLLELFDKNTAAAVELDLICQFNDRDNFWAIFRGINRYKFTKVLPAVGHSYLREIIMKKEKKSIEFSLTDLGTKQNETFSFDVSSEDKRFSYQGGNHFTGIEWWNKASGSNGNTPFPIRYKVEVSNLSFGQATDGTPTRPPIDYRPYNMLIPNRDDVSRVKNYPVSFENPAVKDDGKSIRYAVASGETIAGIRFICDLRGIPEAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPJ1</accession>
    <name>A0A075MPJ1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">NTE_00632</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699628.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPJ1"/>
    <dbReference type="STRING" id="1459636.NTE_00632"/>
    <dbReference type="GeneID" id="41596495"/>
    <dbReference type="KEGG" id="nev:NTE_00632"/>
    <dbReference type="eggNOG" id="arCOG01180">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018693_3_3_2"/>
    <dbReference type="OrthoDB" id="31344at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05145">
        <property type="entry name" value="RIO1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051272">
        <property type="entry name" value="RIO-type_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018934">
        <property type="entry name" value="RIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45723">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01163">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="84"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="27"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AIF82712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="289" mass="33128" checksum="B47C4DFD45174ED3" modified="2014-10-29" version="1">MGKEEGEEDQRPEEEEEHYHHQQQQQRQEEEPKAVARADRRYRRHERENRFLDKRSEDYQVVEEVFDMPTMMVITKMVNDGILKSVQSHFASGKEAKVFIAEAPDGSPLAVKIYLTVSAEFKKRMQYIAGDPRFSEIKGGTRNFIAAWARKEFKNLQQAHKAGVRAPAPIAVEKNVLVMEFIGDSEGNVATPLASLEDMTPADYSEVVKQLQILYQKAGLVHADLSEYNIFKNPQGEIILLDFGSAVDVKHPYSKQFLVRDVQNVNRFFIKRGIDVIDTTHLMEKIMTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPJ7</accession>
    <name>A0A075MPJ7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699961.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPJ7"/>
    <dbReference type="STRING" id="1459636.NTE_01065"/>
    <dbReference type="GeneID" id="41596885"/>
    <dbReference type="KEGG" id="nev:NTE_01065"/>
    <dbReference type="HOGENOM" id="CLU_1405919_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="193" mass="20994" checksum="82773BD8212EFD7D" modified="2014-10-29" version="1">MTIYELPVKTHYYLLILLAAATVLGPVALTARTGTIFATAYAQHQHEDDNNSDDDGAGHKMDTDMKMMNMATSADGTRPLPKSPFVYSDTSSGILVKVSWKPDSVNTKAPTKFTFEFLNSTTGDHLRDVSYSVHMLLDGKGVEHGHKTSAPDGVGTLEHKFDSKGLLSVMVESIRVERTPTNAVVQLDIPVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPJ9</accession>
    <name>A0A075MPJ9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00647</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699640.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPJ9"/>
    <dbReference type="STRING" id="1459636.NTE_00647"/>
    <dbReference type="GeneID" id="41596510"/>
    <dbReference type="KEGG" id="nev:NTE_00647"/>
    <dbReference type="eggNOG" id="arCOG04153">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142666_0_0_2"/>
    <dbReference type="OrthoDB" id="31046at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="148" mass="16842" checksum="596EE3E993A4CB0C" modified="2014-10-29" version="1">MKLNEAQIEDLTGKVFRTIVSNGKGGILQSELWKELDLTSRDGSRVAIRLERRALIRREKMLENGRWTYKLFATKLPIDTSSVENAPCLTCPVEHMCSIDGSYSPITCNLIEDWLVLSLNMANQQQRRPSQQDQQSSTSKTEEVDPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPK2</accession>
    <name>A0A075MPK2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Polyketide cyclase / dehydrase and lipid transport</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699965.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPK2"/>
    <dbReference type="STRING" id="1459636.NTE_01070"/>
    <dbReference type="GeneID" id="41596889"/>
    <dbReference type="KEGG" id="nev:NTE_01070"/>
    <dbReference type="eggNOG" id="arCOG10535">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2021573_0_0_2"/>
    <dbReference type="OrthoDB" id="7552at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="134" mass="14953" checksum="680FB9FF15A26D6C" modified="2014-10-29" version="1">MSKEPRKVIVKTLTTSKDVHGAFTYFEDMKNLEAGGAIKSLVKTGDGGWWSGDTPAGKARIRHTLVSKEHGILDHVFAGQGITWDVYVRIVPNNGGATVSWTFVRPNGMTDGQFEEQLKAFDTEIENWERDLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPV2</accession>
    <name>A0A075MPV2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01082</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385120.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPV2"/>
    <dbReference type="STRING" id="1459636.NTE_01082"/>
    <dbReference type="GeneID" id="43502593"/>
    <dbReference type="KEGG" id="nev:NTE_01082"/>
    <dbReference type="HOGENOM" id="CLU_3057263_0_0_2"/>
    <dbReference type="OrthoDB" id="6019at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="52" mass="5672" checksum="0AC86BDF63E80C06" modified="2014-10-29" version="1">MQLKDLVDGTVVGSGSDYIVIQKGKKRLLVECAGFKVQELKSHGTPYGSQFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPY1</accession>
    <name>A0A075MPY1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_01160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPY1"/>
    <dbReference type="KEGG" id="nev:NTE_01160"/>
    <dbReference type="HOGENOM" id="CLU_2010005_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="64"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF83233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="123" mass="14451" checksum="DC0E83EB4BA94FBC" modified="2014-10-29" version="1">MWQDLLLVWGCMPELTRDCQDMTNASSTYLRIVIGAIIGGIVGWWIYNRQKKTADEQDATLERIKRLDERHDNILKRLEEHEKDRDATLNRLLELDKKIQRIVEKQDKIEKSIQSALKEKGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQ41</accession>
    <name>A0A075MQ41_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01221</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700084.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQ41"/>
    <dbReference type="STRING" id="1459636.NTE_01221"/>
    <dbReference type="GeneID" id="41597029"/>
    <dbReference type="KEGG" id="nev:NTE_01221"/>
    <dbReference type="HOGENOM" id="CLU_1880966_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="140" mass="16262" checksum="B27039488A788F94" modified="2014-10-29" version="1">MGDLNSFNPDDIPASKKTRNVVAGDINVGKKSPAELEQGHIEEDLQTQVSATDSIFSLQSLDDKTQRELAEFAGYYYERGRITQPSIQVLIQYHFQEIMERMRSEYQSYIFNKQLEEMMMKKMGVNPDMVFSKFNNFYLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQ74</accession>
    <name>A0A075MQ74_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AbiTii domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00957</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQ74"/>
    <dbReference type="KEGG" id="nev:NTE_00957"/>
    <dbReference type="HOGENOM" id="CLU_1335008_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="205" mass="21845" checksum="A6212A25CEAFF74E" modified="2014-10-29" version="1">MHRVYELTCGNEHTSVNMWQVGQELGFGEGHSELTHIIVQYLTGEGLITGTGIGGNIGITHFGIKEVEEALEHPEQPTEHFAPLATVNIIHVGQMNNSQIQASGANSSQTATLTQSSGISQEQLVELRDIISMLRETASTADLTPEQKGELNTEIETLALQAQSSKPKSQRIKECLVTAKNILEGVAAGAAIVARIGALLNGLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQD2</accession>
    <name>A0A075MQD2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01213</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700077.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQD2"/>
    <dbReference type="STRING" id="1459636.NTE_01213"/>
    <dbReference type="GeneID" id="41597022"/>
    <dbReference type="KEGG" id="nev:NTE_01213"/>
    <dbReference type="eggNOG" id="arCOG11557">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025569_2_1_2"/>
    <dbReference type="OrthoDB" id="11919at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="498" mass="57202" checksum="A579D4C8C158EBB6" modified="2014-10-29" version="1">MSGQRVEDSKENSNKEKISLEKELFDHAKSLVGQSFKDDFGRAYIEIVVDGHTEIVAIESQDFKHFLSREFQNHKDMLISEELVRKIQFNMVSQALYSKNKRKLYVRLAQEDNAIYYDLCNDNWEVVKITSKGWEILGSGLSSPQKMIFKRNNNNRPQVYPSRTYRPTILADYIGLLNIKDEDQRVLVESYLISLFVENISHAAISPYGEWGTAKSTFCKLLKRVVDPATVELWKLSKKEEDTIQQLSHNYLLFYDNLSGINESTSDLFCQAITGAGFGKRKHYENDEDFLYNFKRCIGFNGIGQVASKGDLLERSIPIELAAIEKRKSDEEIDNRVRELMPELLGYLFDTLVKYLQEKEKGGIKLSKEFRMKDFAEACEIISRKIGYAEDVFTNAYSRIVDLQTELAIESNPVAQVITLLMENNKNVEDTPTKLKNRLDGIAETSGINVKDKTLWPQNLKAMSLKIKESAPNLRKLGIEVQIDRSSARRRILITKVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQL9</accession>
    <name>A0A075MQL9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative HD superfamily hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987185.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQL9"/>
    <dbReference type="STRING" id="1459636.NTE_01089"/>
    <dbReference type="GeneID" id="41596905"/>
    <dbReference type="KEGG" id="nev:NTE_01089"/>
    <dbReference type="eggNOG" id="arCOG01860">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036524_3_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33594:SF1">
        <property type="entry name" value="HD_PDEASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33594">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G03035)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="21"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="209" mass="23755" checksum="7ED84D68D3BAE312" modified="2014-10-29" version="1">MLDDIKLEVERMLAGRDPGHDFAHVTRVYKTAERIGRKESADMEILLASALLHDIIVYPKGSDKRTKSADESAELAEKMLAARGWTKDRIDRVSYCIRVHSYSKNIANPEILEAKILQDADRLDALGAIGIARTFSVGGSEMRRFYNPEDPFCKTNRKPEDTRWTVDHFKAKLLKLENTMHTATAKKIASERTRFMEAFLAQLEKEISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQR1</accession>
    <name>A0A075MQR1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetyl-CoA acetyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_01815</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.9" evidence="4"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700571.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQR1"/>
    <dbReference type="STRING" id="1459636.NTE_01815"/>
    <dbReference type="GeneID" id="41597580"/>
    <dbReference type="KEGG" id="nev:NTE_01815"/>
    <dbReference type="eggNOG" id="arCOG01278">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035425_4_0_2"/>
    <dbReference type="OrthoDB" id="167534at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00829">
        <property type="entry name" value="SCP-x_thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055140">
        <property type="entry name" value="Thiolase_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42870">
        <property type="entry name" value="ACETYL-COA C-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42870:SF6">
        <property type="entry name" value="ACETYL-COA C-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22691">
        <property type="entry name" value="Thiolase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="2">
        <location>
            <begin position="20"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="3">
        <location>
            <begin position="225"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF83876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="365" mass="38926" checksum="514F1A1211A54473" modified="2014-10-29" version="1">MRRVAISAAATSKFTKAIERSIFDVACEPCIEILKSYGSKDVDAVLFSTCATEQYGSTIISERLGVKPKMSQRVDNLCNSGTNAIATAYSLIASGLCESALVVGAEKAHSEGNRLVWDVTRGSFNFPVHWASMFARSHMRCFGTTEEQMAQVSVKNHKNAAKNKNALFFQKPVTIKDVMESKMIAEPVKLLDCSAPCDGASAVLLLSEQRAKKAENDPVWIKGIGQKTSGASFASMDDLTALETAKRAARDAYEMANVKPSQVDVAELHDAFTILEIMAYEDLGFAQKGKGGKFVEQQDIAINPRGGILGCGHPVGATGVAQVAEITLQLSGKAGKRQVKGCRTGLVHNLAAAGSSATVMVLGIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQX1</accession>
    <name>A0A075MQX1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01892</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQX1"/>
    <dbReference type="STRING" id="1459636.NTE_01892"/>
    <dbReference type="KEGG" id="nev:NTE_01892"/>
    <dbReference type="HOGENOM" id="CLU_3020785_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="55" mass="6308" checksum="F5F7B74178E6F09B" modified="2014-10-29" version="1">MGIVCACAFYTLLLLEMTKMIRKKSYKPVCHKVSSLKSFFSISCAAIFIYEYSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQZ3</accession>
    <name>A0A075MQZ3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SpoVT-AbrB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700367.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQZ3"/>
    <dbReference type="GeneID" id="41597350"/>
    <dbReference type="KEGG" id="nev:NTE_01570"/>
    <dbReference type="eggNOG" id="arCOG03937">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2257318_0_0_2"/>
    <dbReference type="OrthoDB" id="6319at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="AbrB/MazE/MraZ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="103" mass="11413" checksum="37A3EAA56FE202BB" modified="2014-10-29" version="1">MSSSNDNPTDPVDAFKKALEKGGEVQKDFARQFSAMQADAMQNYLAMLRGLSFYNAMFKTTVQSGGRISIPEAERQALDIDDGDLVQVIVIPIERRRKKATDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MR17</accession>
    <name>A0A075MR17_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01482</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MR17"/>
    <dbReference type="STRING" id="1459636.NTE_01482"/>
    <dbReference type="KEGG" id="nev:NTE_01482"/>
    <dbReference type="HOGENOM" id="CLU_3371268_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="34" mass="4016" checksum="99C03AC3AC796B73" modified="2014-10-29" version="1">MSHIIVRLSAKNYVAKDSIMLCKLMMPIMYKEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRF4</accession>
    <name>A0A075MRF4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRF4"/>
    <dbReference type="STRING" id="1459636.NTE_02075"/>
    <dbReference type="KEGG" id="nev:NTE_02075"/>
    <dbReference type="HOGENOM" id="CLU_3112877_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="50" mass="5668" checksum="A57DAAD333D562AF" modified="2014-10-29" version="1">MAAKDNDTKITSEPEKQELVITRSLTRRASLCSTHTPIQNFMYNGLDREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRP2</accession>
    <name>A0A075MRP2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HIT family hydrolase, diadenosine tetraphosphate hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_01767</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700530.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRP2"/>
    <dbReference type="STRING" id="1459636.NTE_01767"/>
    <dbReference type="GeneID" id="41597537"/>
    <dbReference type="KEGG" id="nev:NTE_01767"/>
    <dbReference type="eggNOG" id="arCOG00419">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056776_3_3_2"/>
    <dbReference type="OrthoDB" id="26806at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01277">
        <property type="entry name" value="HINT_subgroup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039384">
        <property type="entry name" value="HINT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648:SF1">
        <property type="entry name" value="ADENOSINE 5'-MONOPHOSPHORAMIDASE HNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648">
        <property type="entry name" value="HIT FAMILY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="4">
        <location>
            <begin position="6"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="2 3">
        <location>
            <begin position="98"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="1">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF83828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="144" mass="15864" checksum="E5D73CEB0452194B" modified="2014-10-29" version="1">MPKPCIFCSIIAGELPSAQVYKDEDLLVIMDKYPINPGHTLVIPVKHHNTLLDMPPAEVAKLYAAIPRIAKAVVDVVSADGFNVGQNNGIAANQIIPHVHVHIVPRFADDSPDGKWPARRVAPEEELEKMAQKVRQKLVPLRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRR2</accession>
    <name>A0A075MRR2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01714</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRR2"/>
    <dbReference type="KEGG" id="nev:NTE_01714"/>
    <dbReference type="HOGENOM" id="CLU_1615234_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="171" mass="18399" checksum="AEAC5DAAA45A6029" modified="2014-10-29" version="1">MNFGIFANFACAAAAAIIVMSILLLPLSKVLAEEQVTRGAGELDRFAGYSRVHLSDDTFTLRSGEERVVNFTGISTAESGAYIVGNATVEGGGVRIKITDSHGRCPGVDMCTSISVYSKDAPWSYYDGDVKDVEIPISKGMTQVVFYTPYEQGSTIAFNFDVVEKVVDSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRU1</accession>
    <name>A0A075MRU1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Phosphate transport system permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NTE_00045</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699193.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRU1"/>
    <dbReference type="STRING" id="1459636.NTE_00045"/>
    <dbReference type="GeneID" id="41595997"/>
    <dbReference type="KEGG" id="nev:NTE_00045"/>
    <dbReference type="eggNOG" id="arCOG00167">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033621_1_3_2"/>
    <dbReference type="OrthoDB" id="338493at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="entry name" value="MetI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011864">
        <property type="entry name" value="Phosphate_PstC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051124">
        <property type="entry name" value="Phosphate_Transport_Permease"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02138">
        <property type="entry name" value="phosphate_pstC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30425">
        <property type="entry name" value="PHOSPHATE TRANSPORT SYSTEM PERMEASE PROTEIN PST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30425:SF1">
        <property type="entry name" value="PHOSPHATE TRANSPORT SYSTEM PERMEASE PROTEIN PSTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="MetI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="90"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="128"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="91"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIF82129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="336" mass="35583" checksum="19FE99936824DAF6" modified="2014-10-29" version="1">MTSPPSFSESRKERKEFLSSFFLSAKRRGDGLFKWVVIGGAAYTLCMLLLVVFSVVDGSLPILFYQGPGFFTGTGWNPVEGRESYGALPYVIGTLASSGIAMAIGVPISLGIAVFITEIAPAKVGTPVGFVIEILAAIPSIVYGLWALFVFRFWILDYIEAPLYDTLGQSIPFFGPGPFGLDIFTAGIVLAIMIIPIVSAISREVLRAVPNSQREAAYSLGATRWEAVWHFIFPYAKAGILGAAILGLGRAVGETMLVTMVIGNTVGLAAIPDGLFSPGQTLSSLIANEFNEAASPLHASALIGLGATLFILTMAINIGAQLLVSRMVKVAPGAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRV3</accession>
    <name>A0A075MRV3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">tRNA-intron endonuclease</fullName>
            <ecNumber evidence="6">4.6.1.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NTE_01764</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.16" evidence="6"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700527.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRV3"/>
    <dbReference type="STRING" id="1459636.NTE_01764"/>
    <dbReference type="GeneID" id="41597534"/>
    <dbReference type="KEGG" id="nev:NTE_01764"/>
    <dbReference type="eggNOG" id="arCOG01701">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114393_0_0_2"/>
    <dbReference type="OrthoDB" id="46045at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22363">
        <property type="entry name" value="tRNA-intron_lyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1350.10:FF:000006">
        <property type="entry name" value="tRNA-splicing endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.20">
        <property type="entry name" value="tRNA intron endonuclease, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006677">
        <property type="entry name" value="tRNA_intron_Endonuc_cat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006678">
        <property type="entry name" value="tRNA_intron_Endonuc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036740">
        <property type="entry name" value="tRNA_intron_Endonuc_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006676">
        <property type="entry name" value="tRNA_splic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016442">
        <property type="entry name" value="tRNA_splic_arch_short"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00324">
        <property type="entry name" value="endA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13070:SF0">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13070">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01974">
        <property type="entry name" value="tRNA_int_endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02778">
        <property type="entry name" value="tRNA_int_endo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005285">
        <property type="entry name" value="tRNA_splic_archaea"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="tRNA-intron endonuclease catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55267">
        <property type="entry name" value="tRNA-intron endonuclease N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA intron endonuclease N-terminal" evidence="5">
        <location>
            <begin position="6"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA intron endonuclease catalytic" evidence="4">
        <location>
            <begin position="94"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF83825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="187" mass="20916" checksum="F6784C4A1AA39FE4" modified="2014-10-29" version="1">MSVVVNGRLFGNRIIVWDIADSRKLYGSGYYGKPIGVPKPKGVEFDAPLVLDLMEGCYLAEKGRLKISQMDSSNSKPVSQTEIKKICKKQYVDFDAKYLVFSDLREKGYVVSPGIKFGCDFAVYEQGPGIDHAPYLVQVFRATDEMTATGVVLAGRLATTVKKQFILAIPKVTEKKVEYVGFDWWRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRW8</accession>
    <name>A0A075MRW8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02197</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRW8"/>
    <dbReference type="STRING" id="1459636.NTE_02197"/>
    <dbReference type="KEGG" id="nev:NTE_02197"/>
    <dbReference type="HOGENOM" id="CLU_2285138_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="102" mass="11521" checksum="1BB27CA5A3339DAD" modified="2014-10-29" version="1">MKVSELCTMIQDSIRSGRYPLATETEKKFAGAIQVMLKSGTDDLKAKDIAVEVRVHDLYVVNNYVPNIQHLPGVIEAEIVDSYRMICRKIDRLDSGVQLKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRZ1</accession>
    <name>A0A075MRZ1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carbonic anhydrase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02222</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700882.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRZ1"/>
    <dbReference type="GeneID" id="41597943"/>
    <dbReference type="KEGG" id="nev:NTE_02222"/>
    <dbReference type="eggNOG" id="arCOG08826">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_152017_0_0_2"/>
    <dbReference type="OrthoDB" id="9675at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046871">
        <property type="entry name" value="Pro_CA_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20393">
        <property type="entry name" value="Pro_CA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="127" mass="14281" checksum="84BFB5C19B69B984" modified="2014-10-29" version="1">MTGFRFGTAINCIDGRTQQVVIDYMKQSFGVDGVDMVTFPGADGMLSNWERSEDLALIKQATSISTERHGSKVIAVVGHHDCAGNPGNKEHHYAHIRRAVQEVHSWKFPVQIIGLYVNDKWKIEEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MS56</accession>
    <name>A0A075MS56_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_02318</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transcriptional regulator TrmB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MS56"/>
    <dbReference type="STRING" id="1459636.NTE_02318"/>
    <dbReference type="KEGG" id="nev:NTE_02318"/>
    <dbReference type="eggNOG" id="arCOG02038">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072493_0_1_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09124">
        <property type="entry name" value="PLDc_like_TrmB_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051797">
        <property type="entry name" value="TrmB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021586">
        <property type="entry name" value="Tscrpt_reg_TrmB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002831">
        <property type="entry name" value="Tscrpt_reg_TrmB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34293">
        <property type="entry name" value="HTH-TYPE TRANSCRIPTIONAL REGULATOR TRMBL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34293:SF1">
        <property type="entry name" value="HTH-TYPE TRANSCRIPTIONAL REGULATOR TRMBL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11495">
        <property type="entry name" value="Regulator_TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01978">
        <property type="entry name" value="TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription regulator TrmB N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription regulator TrmB C-terminal" evidence="3">
        <location>
            <begin position="107"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF84371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="253" mass="27891" checksum="69773156B7C3F18D" modified="2014-10-29" version="1">MEDLGMTGYEIRVYTSLLEAGAMTAADISKKSGVPYSKIYEVLNSLEDKGWLESDSSRPQKFFPKSPSTALEAMRMRSENSFRESQAAIVNELMPIYTKSGIKEKPEIWVVRGVYNIAAKVSEIVENCQQELLVALPSVAQDVAKPMQPVLRTLYERGVKINVLASEDTSADIVRALSRVAEVKLKNGMFGGGVIGDGKHVMILLGEGMIENGMIDPIAIWADHAALAGFAKDYFHYLWADAKAQQKKANSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MS60</accession>
    <name>A0A075MS60_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01891</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MS60"/>
    <dbReference type="STRING" id="1459636.NTE_01891"/>
    <dbReference type="KEGG" id="nev:NTE_01891"/>
    <dbReference type="HOGENOM" id="CLU_2243700_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="104" mass="12036" checksum="7FF05C471039B22D" modified="2014-10-29" version="1">MLINQTYNSFLIAYSGTNYYTASTLLKSLSRLVGAKIPQPPLRPPKVSILVNQKPWEDYCAAQLDNVMISTDKYLKRHGNVSSVRLWTDEDERREREEQEEEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSA1</accession>
    <name>A0A075MSA1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02394</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701017.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSA1"/>
    <dbReference type="GeneID" id="41598104"/>
    <dbReference type="KEGG" id="nev:NTE_02394"/>
    <dbReference type="HOGENOM" id="CLU_084395_0_0_2"/>
    <dbReference type="OrthoDB" id="12176at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13412">
        <property type="entry name" value="HTH_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="252" mass="28005" checksum="B5B5C7B6D911A0E0" modified="2014-10-29" version="1">MKRENDSSAILKNPFVDQGMLEGRQEDVADMIKHETSPFKKATSRDEILAEFREMGVTDNVFSSVPTNTLARLLENIKTAATEQRYPKVHSGGPSSPPILSTVDKKILKALLSSTGGVSSLTLSKELDIPLSTVQRRRKRLEANLLEMSYTLKVERFGWRTATLFISTRNGMTAAVGKEILSLSDGVKSVNRILGENSADLMVEIIFRNNAELLNMVEKMKSINGVGNVFWIELIEPMGKNTDFAERVIEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSI9</accession>
    <name>A0A075MSI9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02067</name>
        <name evidence="3" type="ORF">NTE_03467</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSI9"/>
    <dbReference type="KEGG" id="nev:NTE_02067"/>
    <dbReference type="KEGG" id="nev:NTE_03467"/>
    <dbReference type="HOGENOM" id="CLU_3130981_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="19"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF85495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="51" mass="6036" checksum="291A6073641473D7" modified="2014-10-29" version="1">MTYSVMEKSRKEKLEGFECEVCHLRFANKTYLESHIIIIEHKKHMVPSGVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSL1</accession>
    <name>A0A075MSL1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02087</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700772.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSL1"/>
    <dbReference type="STRING" id="1459636.NTE_02087"/>
    <dbReference type="GeneID" id="41597821"/>
    <dbReference type="KEGG" id="nev:NTE_02087"/>
    <dbReference type="HOGENOM" id="CLU_2695533_0_0_2"/>
    <dbReference type="OrthoDB" id="374467at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="73" mass="8366" checksum="71FEB4A123A54810" modified="2014-10-29" version="1">MSSDSETMTRILKESMNILGENTYEALKFHMKEKYGIDLAHNPRLENVESALRDLFGPGAEIIMIQIRRRLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSN2</accession>
    <name>A0A075MSN2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02108</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700788.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSN2"/>
    <dbReference type="STRING" id="1459636.NTE_02108"/>
    <dbReference type="GeneID" id="41597839"/>
    <dbReference type="KEGG" id="nev:NTE_02108"/>
    <dbReference type="HOGENOM" id="CLU_2839206_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="65" mass="7231" checksum="3D3E6F19ACD109C0" modified="2014-10-29" version="1">MSDKFELVNVKINDKPAQVVRRRPGLVDLEDDVLDLAKISLAINTKGASLDKNGEIVVALRFRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSN9</accession>
    <name>A0A075MSN9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSN9"/>
    <dbReference type="STRING" id="1459636.NTE_02100"/>
    <dbReference type="KEGG" id="nev:NTE_02100"/>
    <dbReference type="HOGENOM" id="CLU_1792031_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="144" mass="16509" checksum="BB010C562616B1A2" modified="2014-10-29" version="1">MVVHCYSLIDYGVLLYGGMSVAGAWGVSHLAKKLSKRMKGKYKSVPKFVNFLATFMTVAYSIAEVSSIIHQSGAPTIFMLGPLALFGVYYWRHFKEDLRTIRPRMWRMWFKYVFVMGCMALAPIVYFLLAFSVLELQYNILPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSP9</accession>
    <name>A0A075MSP9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NTE_02123</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSP9"/>
    <dbReference type="STRING" id="1459636.NTE_02123"/>
    <dbReference type="KEGG" id="nev:NTE_02123"/>
    <dbReference type="eggNOG" id="arCOG02358">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG03644">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031353_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00075">
        <property type="entry name" value="HATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050736">
        <property type="entry name" value="Sensor_HK_Regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43711:SF1">
        <property type="entry name" value="HISTIDINE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43711">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="404"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="189"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIF84178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="642" mass="70303" checksum="13432B28137D5894" modified="2014-10-29" version="1">MALNKIFSRKNVFLVVLIVVVAFSLSALSYQQSSHISQQIEQMSTSDIRSNADIQTHDLANLVSNEISHVQSVSQMLSKSPPIQGGDFEKAKETLNQAEDSSGRIVDFYMWLDKDGRLVWLSKMNQTAYQQYKDFDLSYRLYFIHPRDTHEVYYSSVIDSNDRIHRLYISYPILKEEAGGTILTPASPPGTSSSTSVNSSSGENNATQGQFEGIIVAGIRTDIFGKLLEGQISPNLQSQVGLLDNRGIILYSNHTEYMGKNVFGYKFQSFLGGFDAETGRAMNEGFKAALAGNSGSRDIAMGGDGNKATFVYKPIILDGKQFGALYVIASHAQASDTAALVNAQKNLSTGVIGVIGASALGIIFAILLWNKRLEETVSARTGELKTANEQLKAHDKMQTEFVNIAAHELRTPVQPIVGMIDMLKYRLDSNGSGNGKSRVEVTEEQLALMDRNARRLQKLSSEILDATRIEAGTLRLDMEVMDINDKVRSVIADAKSMVPSDQSIDIQFKPATDDSGRPIPLLVKADKLRIFQVISNLVRNAIKFSAEGGVITITTDKREDGYAIVSVKDQGAGISAEVLPRLFTKFSTDRERGGTGLGLFIAKNIVEAHGGRIWAENNKDNKDGERGATFSFTLPLAATKPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSQ4</accession>
    <name>A0A075MSQ4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSQ4"/>
    <dbReference type="STRING" id="1459636.NTE_02120"/>
    <dbReference type="KEGG" id="nev:NTE_02120"/>
    <dbReference type="eggNOG" id="arCOG01720">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_820404_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="338" mass="36314" checksum="8B55C17377A8482B" modified="2014-10-29" version="1">MIAIVVSAALVASLLFAMPYFSLGALKSDVPVRIFALDPRKYGAGTGDDGEPITMNAVKVDDLKPNSFVWFLDPYGKTMKTLLANSAAGNNKTSITLDSKQMEQFQNRDPYEYYMLIRLPEWLGGGSGYHDGTGNGGNASSNENNNSSSGVATLRAYHSISLSDKCTAKYFPDEGRTRIENPCAGDMYRPWDGFAIAGPAHQGFVGMVPSKGYYPALQMLRLSVDGGGYVVAFRPDNNPRGDGVQGEGRLMSPDELAESNTKMVLAASQYSGFALPFPATMPPDYVLGWIEPNYNSGRPAMSPGLPEAGDVNRLPLQATYISAGGNQATTTIDAFPQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSQ5</accession>
    <name>A0A075MSQ5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01751</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSQ5"/>
    <dbReference type="STRING" id="1459636.NTE_01751"/>
    <dbReference type="KEGG" id="nev:NTE_01751"/>
    <dbReference type="eggNOG" id="arCOG08672">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2581536_0_0_2"/>
    <dbReference type="OrthoDB" id="5956at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="85" mass="9814" checksum="FC37129DC1EE98B9" modified="2014-10-29" version="1">MLMNFGSLGSLLGQIGPNYDPLFYDVMVYIFGTMLFAVFLLGVIAFWLRRKGLGGGSAKEKWAQELERYFEREQIGLIPDEKHHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSS8</accession>
    <name>A0A075MSS8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01776</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSS8"/>
    <dbReference type="STRING" id="1459636.NTE_01776"/>
    <dbReference type="KEGG" id="nev:NTE_01776"/>
    <dbReference type="HOGENOM" id="CLU_2820604_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="66" mass="7588" checksum="FB22E2DA1689610A" modified="2014-10-29" version="1">MGLNNQTTVTAELGKELYCQHCTYIWTYRGRSIFHTACPHCGFRVRVHLGEARAKAFRNGMVERAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSZ2</accession>
    <name>A0A075MSZ2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ArnR1-like winged helix-turn-helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSZ2"/>
    <dbReference type="STRING" id="1459636.NTE_02256"/>
    <dbReference type="KEGG" id="nev:NTE_02256"/>
    <dbReference type="eggNOG" id="arCOG01055">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_159725_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038723">
        <property type="entry name" value="ArnR1-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14947">
        <property type="entry name" value="HTH_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ArnR1-like winged helix-turn-helix" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="76" mass="8792" checksum="189EC5AA0A6EC29C" modified="2014-10-29" version="1">MLEEAEGGEVNQTMIMYKSFVSLQQLKQYLAILIDNGMLEYAAETRLYRTTEKGRAFRKAYDEVAGALRPKESRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MT36</accession>
    <name>A0A075MT36_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02322</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700956.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MT36"/>
    <dbReference type="STRING" id="1459636.NTE_02322"/>
    <dbReference type="GeneID" id="41598038"/>
    <dbReference type="KEGG" id="nev:NTE_02322"/>
    <dbReference type="HOGENOM" id="CLU_2930030_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="60" mass="6772" checksum="479ADC9231EFDAEA" modified="2014-10-29" version="1">MEKTMKLWVIYLTTPYGKATEIFGVFDSKDKAERARANASSRGHGGARIVERLLNSETLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MT96</accession>
    <name>A0A075MT96_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00457</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699490.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MT96"/>
    <dbReference type="GeneID" id="41596333"/>
    <dbReference type="KEGG" id="nev:NTE_00457"/>
    <dbReference type="HOGENOM" id="CLU_800773_0_0_2"/>
    <dbReference type="OrthoDB" id="11836at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="346" mass="35541" checksum="92E01FA5C51585E5" modified="2014-10-29" version="1">MSASDKVLYLLTIGLIVASSGIVMPLAFAKPVSDQNTSVAIGTSVTNPSTDEGNGSSSSSSSSLQNSEAPTADAQSFDANGTINAVTFITKFLKYDLQGVWSMHVRDGNVVQFEGSMAAIPSSQELGKSHTHQLLNFEPGEIGIRDSDNNFFTNGTIDVGTNNSVTWTGVPVVISIRDGSSIIIAIDDESAGHHFAGQPIVGTVESIINCSSTPGPAMSIESVCQATETDTGTEEGGNGSVGGGSENSGGGGSEQIITVTIDSDRFGPNEIPQVTGKVNDPVSGTVAQVDVSDSSGKVVYNTVAGVSSDGSFFTTLKNFSPGQYTVVVTYHGNTGTASFEVVETGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTA8</accession>
    <name>A0A075MTA8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00467</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTA8"/>
    <dbReference type="STRING" id="1459636.NTE_00467"/>
    <dbReference type="KEGG" id="nev:NTE_00467"/>
    <dbReference type="eggNOG" id="arCOG03570">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056435_4_3_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12843:SF5">
        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12843">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE METTL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="58"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="210" mass="24071" checksum="CE96A20ECD411A1E" modified="2014-10-29" version="1">MPGNISSSENSRFFPDWDWEELYSYGPRVKRLPWFTEHLDADLKNELNIRKISSGKFLDIGTGVGSHAIELSKLGFEVTATDISQNAIDRARALSKDVTFFVDDIIHSRLSEEGYVFDYAFDRGCFHTLDPKYRSQYVTQVKKLIVSEGLFFLKTFSTKQPQGPGPHRFSTDMMAKYFGDHFKILKSIETVYEGTLRVLPKALFTVMAKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTC3</accession>
    <name>A0A075MTC3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lactate dehydrogenase-like oxidoreductase</fullName>
            <ecNumber evidence="5">1.1.1.26</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_02310</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.26" evidence="5"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148702129.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTC3"/>
    <dbReference type="STRING" id="1459636.NTE_02310"/>
    <dbReference type="GeneID" id="41598025"/>
    <dbReference type="KEGG" id="nev:NTE_02310"/>
    <dbReference type="eggNOG" id="arCOG01755">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019796_1_2_2"/>
    <dbReference type="OrthoDB" id="7437at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047964">
        <property type="term" value="F:glyoxylate reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016618">
        <property type="term" value="F:hydroxypyruvate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05301">
        <property type="entry name" value="GDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000462">
        <property type="entry name" value="Glyoxylate reductase (NADP+)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF283">
        <property type="entry name" value="GLYOXYLATE_HYDROXYPYRUVATE REDUCTASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="3">
        <location>
            <begin position="10"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="4">
        <location>
            <begin position="113"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF84363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="333" mass="36534" checksum="7D3C79B0742C0A2E" modified="2014-10-29" version="1">MAHVGNNKVYITRKLPGPALEMLQEFDVTLHKRQEPPTRKEILKNVAGKDAILCMLSDKIDKEVMDAAGPQLKIISSYSTGFEHIDVAEATKRGIYVTYTSDILAEATADITFALILACARNVVAGDRMVRQKKWKVGWMPDLLLGQNVHGATIGIVGLGKIGSAVARRARGFGMEILYHSRRRNEAAEQELGARYADLDYLLAQSDFVTIHTTLNDASRHLVNSERLQKMKRTAFFINTARGAVVNERDLAAALKKGIIAGAGLDVFEKEPLGGKSPLLAMKNVVLLPHIGSADRMTRSKMAEVAAKSILDVLAEGKEPDPKFLVNPPAKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTQ1</accession>
    <name>A0A075MTQ1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02091</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTQ1"/>
    <dbReference type="STRING" id="1459636.NTE_02091"/>
    <dbReference type="KEGG" id="nev:NTE_02091"/>
    <dbReference type="HOGENOM" id="CLU_2433972_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="95" mass="10899" checksum="0E8A215FF4086FFE" modified="2014-10-29" version="1">MTSLTEVAMTATLEHVQSHGIMTPDEAAFCDYLNASLQSRNLDAHFNYVRHKKSGGFDFDLEENIQDERYLDVFDGLTMSGWLRFQSERSIAFTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MU30</accession>
    <name>A0A075MU30_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00714</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699694.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MU30"/>
    <dbReference type="STRING" id="1459636.NTE_00714"/>
    <dbReference type="GeneID" id="41596567"/>
    <dbReference type="KEGG" id="nev:NTE_00714"/>
    <dbReference type="HOGENOM" id="CLU_2645692_0_0_2"/>
    <dbReference type="OrthoDB" id="375538at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="76" mass="8516" checksum="EDB8FA19D7697CCD" modified="2014-10-29" version="1">MFASSVDALLYAIRNGRGITDVQANLGYLRNGIKRCCVQVVCKDGAEFHIEAYGEEADALFHEAKKHRKREYLALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MU63</accession>
    <name>A0A075MU63_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00781</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MU63"/>
    <dbReference type="KEGG" id="nev:NTE_00781"/>
    <dbReference type="eggNOG" id="arCOG08681">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102441_0_0_2"/>
    <dbReference type="OrthoDB" id="9956at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="241" mass="27357" checksum="CFF3655E4E76DFC4" modified="2014-10-29" version="1">MSFDPLYKVHDAARAGQIPEKTYKLIVKRFPLVKEGIKRVEDASGLKYPYFYVEPSMVVSTSAAEFAQFGVFFARTIPVIGDDNLLRVVVQLTAPLVAFGLKGTIHAILAHEFLHYLELVSRIVKMNVISDEISGTLFEGRYADSGKLLEERAVFKSDPTLLKHITTRFPEGFRDYKLEDKSIKLWMDKGLPVIRVPIDANVIKIPVQAMARLQVEQEIRDKIAEFESVKLRKRKSPTGYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MU68</accession>
    <name>A0A075MU68_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03169</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MU68"/>
    <dbReference type="KEGG" id="nev:NTE_03169"/>
    <dbReference type="HOGENOM" id="CLU_3353807_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="36" mass="4174" checksum="19DBCD58901DD63F" modified="2014-10-29" version="1">MDGVDAKINKMHKLKVYAGPEELEFRKIRVRVPMSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUH0</accession>
    <name>A0A075MUH0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 8">Glutamyl-tRNA(Gln) amidotransferase subunit D</fullName>
            <shortName evidence="5">Glu-ADT subunit D</shortName>
            <ecNumber evidence="5 8">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">gatD</name>
        <name evidence="12" type="ORF">NTE_02721</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 8">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 8">
            <text>L-glutamyl-tRNA(Gln) + L-glutamine + ATP + H2O = L-glutaminyl-tRNA(Gln) + L-glutamate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5 8">Heterodimer of GatD and GatE.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 8">Belongs to the asparaginase 1 family. GatD subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="5 8"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226986997.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUH0"/>
    <dbReference type="STRING" id="1459636.NTE_02721"/>
    <dbReference type="GeneID" id="41598411"/>
    <dbReference type="KEGG" id="nev:NTE_02721"/>
    <dbReference type="eggNOG" id="arCOG01924">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019134_2_1_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004067">
        <property type="term" value="F:asparaginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08962">
        <property type="entry name" value="GatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1170">
        <property type="entry name" value="L-asparaginase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00586">
        <property type="entry name" value="GatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006033">
        <property type="entry name" value="AsnA_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036152">
        <property type="entry name" value="Asp/glu_Ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006034">
        <property type="entry name" value="Asparaginase/glutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020827">
        <property type="entry name" value="Asparaginase/glutaminase_AS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027475">
        <property type="entry name" value="Asparaginase/glutaminase_AS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040919">
        <property type="entry name" value="Asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011878">
        <property type="entry name" value="GatD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040918">
        <property type="entry name" value="GatD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037222">
        <property type="entry name" value="GatD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027473">
        <property type="entry name" value="L-asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027474">
        <property type="entry name" value="L-asparaginase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037152">
        <property type="entry name" value="L-asparaginase_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00519">
        <property type="entry name" value="asnASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02153">
        <property type="entry name" value="gatD_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003217">
        <property type="entry name" value="PRK04183.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11707:SF28">
        <property type="entry name" value="60 KDA LYSOPHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11707">
        <property type="entry name" value="L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00710">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17763">
        <property type="entry name" value="Asparaginase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18195">
        <property type="entry name" value="GatD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500175">
        <property type="entry name" value="Glu_ADT_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001220">
        <property type="entry name" value="L-ASNase_gatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00139">
        <property type="entry name" value="ASNGLNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00870">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141300">
        <property type="entry name" value="GatD N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53774">
        <property type="entry name" value="Glutaminase/Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00144">
        <property type="entry name" value="ASN_GLN_ASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00917">
        <property type="entry name" value="ASN_GLN_ASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51732">
        <property type="entry name" value="ASN_GLN_ASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 5 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 5 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GatD N-terminal" evidence="11">
        <location>
            <begin position="21"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="L-asparaginase N-terminal" evidence="9">
        <location>
            <begin position="104"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Asparaginase/glutaminase C-terminal" evidence="10">
        <location>
            <begin position="321"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 7">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIF84763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="445" mass="47146" checksum="F71793AC0E331D57" modified="2014-10-29" version="1">MSSGSYRGAGAELLSKHGVSAGDTVSISIDGGETMTGVLMPRYESASDSYIVIKLKSGYNTGIEAAKIKSITKIAGAAGTAATKVTQQQQPSPPSKQEDVKLPKIALISTGGTIASKIDYRTGGVRAALSAEELYASVPELASIASVDPEVLMSEYSENINPGHWTIMADRIADKVRSGRYDGIIVSHGTDTMHYTASALSFALQGLPIPVVLVGAQRSSDRPSSDAALNLIGATTFAAKAPVAGVFVAMHAGTSDDAVAVHIGTRVRKNHTSRRDAFESIDVTPVALVKDGRVEMQKQSGIDLVPRGKGKLNLQSSFDSRVALVKYHPGFDPTLVYWLISKECGAIVFEGTGLGHVNKNLFGVLKEAAEKGVHMFMTSQCIWGRVSMTVYDTGRDLLDIGVVPLSDMISETAVVKAMWALANTQDLKKTMQENLAGEMSSAIPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUI6</accession>
    <name>A0A075MUI6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">DNA/RNA helicase, superfamily II</fullName>
            <ecNumber evidence="12">3.6.4.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NTE_03297</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="12"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701751.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUI6"/>
    <dbReference type="STRING" id="1459636.NTE_03297"/>
    <dbReference type="GeneID" id="41598951"/>
    <dbReference type="KEGG" id="nev:NTE_03297"/>
    <dbReference type="eggNOG" id="arCOG00558">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_1_3_2"/>
    <dbReference type="OrthoDB" id="4631at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140097">
        <property type="term" value="F:catalytic activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00268">
        <property type="entry name" value="DEADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000108">
        <property type="entry name" value="ATP-dependent RNA helicase RhlE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044742">
        <property type="entry name" value="DEAD/DEAH_RhlB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="11">
        <location>
            <begin position="3"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="34"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="214"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="431"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="6">
        <location>
            <begin position="3"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="431"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIF85326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="462" mass="50258" checksum="D36B7D2093C5B68C" modified="2014-10-29" version="1">MTKTFAELGLSAELNKALSENGFEAPFPIQEAAIPLVLQGKDVIGQAHTGTGKTAAFGLPILARVSNEGPVQALVLVPTRELAVQVTTEISRLAKYTGIKTVAIYGGQSINIQNEKLQRGVQIVVATPGRLIDHIKQGSIILDDVKFVVLDEADRMLDMGFIDDIKFILFYVNEDRQTCLFSATMPPEILRLAEEYMKEIEHVRLNEEEVTLDTIEQSYLVVEEREKFRHLCDFIKKNRDAKAQTIVFAATKQRADRVAHQLKRDGFSAIAIHGDLTQRQRDQAMFKFRKGTEDILVATDIAARGIDVPAVGNVINYDIPDDPNVYFHRIGRTARAGAEGKAISLVSAERIADMECILAQTTLPIRKLNDEMGIAVPVAQPRSYGGGGYRGRQSYGGGGYGSRGYGGGGYGSSGYGSRGYGNSRGGGYGGGGRRGYGQRRGGYGGSRRGGGYGRSSNYGGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUJ2</accession>
    <name>A0A075MUJ2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative copper export protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NTE_02847</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701383.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUJ2"/>
    <dbReference type="STRING" id="1459636.NTE_02847"/>
    <dbReference type="GeneID" id="41598529"/>
    <dbReference type="KEGG" id="nev:NTE_02847"/>
    <dbReference type="eggNOG" id="arCOG06267">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_425551_0_0_2"/>
    <dbReference type="OrthoDB" id="11083at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046688">
        <property type="term" value="P:response to copper ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032694">
        <property type="entry name" value="CopC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007348">
        <property type="entry name" value="CopC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008457">
        <property type="entry name" value="Cu-R_CopD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014755">
        <property type="entry name" value="Cu-Rt/internalin_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34820">
        <property type="entry name" value="INNER MEMBRANE PROTEIN YEBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34820:SF4">
        <property type="entry name" value="INNER MEMBRANE PROTEIN YEBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04234">
        <property type="entry name" value="CopC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05425">
        <property type="entry name" value="CopD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0186">Copper</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="339"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="374"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="433"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="604"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="domain" description="CopC" evidence="10">
        <location>
            <begin position="48"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Copper resistance protein D" evidence="11">
        <location>
            <begin position="337"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIF84885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="638" mass="67408" checksum="48D7FA3D49F994AD" modified="2014-10-29" version="1">MSSHRLSFLVIFALAALALLLPTVEPAFGHAVPAKYSIGPNAQFHEKSELPRQLAISFSERPDPKVSYIRVADAQDQRVDNNDFSVIGENGRQAAVTIDTNKVKDGIYTVSWFTMSLDDGHITEGAYVFGVGHEVMPQQQTPSETRYVTSSEDALAKWPLLVAQAAIVGGAMAHAILQKKLEGRPSRRFSIILLASAGAMAASATVIMLLQAGNLAVAAGAPLGQAVQSLVATSPAGAVWLIRLATSAIVAGAIFAYMVKKNGSKLLLLYAALAAGAVSLFSNSILSHNSAAPFLPALAIALDWTHFMAVSAWVGGLFYLAAVFAPATRQSPRQLATALPTFSLVATASLGVIGVTGIYMAWVHLHMLDSLFSTPYGTSLAIKLAAALPMVLLGAYHQLRLHRELVVIAKRSGRRQQEYAATARFGRTIKAEALVGIGVLLAASFLTITSPPMQAAMEQPGQHFMHQVNIAGTDVALEISPFQPGVNTFTATLLEGDGKPPQNIASVVLRFTNVNAGVGPLVVTLQKAGDGSVYSATGGYLSQAGEWKIDFIAQRINAYDLNHSFVANLGNGSTTTMMPGMATMPGMENNNNPKEMPMPSFDSFAALAMGLAAAVAGGSAFYARQSRIQMKKTLAALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUK7</accession>
    <name>A0A075MUK7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03317</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701766.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUK7"/>
    <dbReference type="STRING" id="1459636.NTE_03317"/>
    <dbReference type="GeneID" id="41598968"/>
    <dbReference type="KEGG" id="nev:NTE_03317"/>
    <dbReference type="HOGENOM" id="CLU_2802404_0_0_2"/>
    <dbReference type="OrthoDB" id="9709at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="71" mass="8204" checksum="09D88A467C103B88" modified="2014-10-29" version="1">MITKNTDPYKMKKCVKCKKDIALNERYFAYPLSLQQMCLDCAEKEIPKTIEGLQKDLEKIKQTKNTTTTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUT5</accession>
    <name>A0A075MUT5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-methylhydantoinase A/acetone carboxylase, beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_02380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701009.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUT5"/>
    <dbReference type="STRING" id="1459636.NTE_02380"/>
    <dbReference type="GeneID" id="41598095"/>
    <dbReference type="KEGG" id="nev:NTE_02380"/>
    <dbReference type="eggNOG" id="arCOG01511">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014140_0_0_2"/>
    <dbReference type="OrthoDB" id="8261at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017168">
        <property type="term" value="F:5-oxoprolinase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="5-OXOPROLINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365:SF23">
        <property type="entry name" value="HYPOTHETICAL 5-OXOPROLINASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase/oxoprolinase N-terminal" evidence="2">
        <location>
            <begin position="9"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase A/oxoprolinase" evidence="1">
        <location>
            <begin position="195"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF84432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="709" mass="75795" checksum="317A1F48D6C55F26" modified="2014-10-29" version="1">MHAAARRIRVGIDVGGTFTKAVAIDMVEGSIIGKVTVPTTHSSGEGVSTGIVQALKTLMQRHAITNSEIELISHSTTQAVNALLEGDTAKVGIVGMGVGLEKSNVIKRTNVRDIELAPNKYLHTCYRFLDTSKYLQDDEVKETISELKSEGAQVIVVSEAYGVDDPSNEQFVMLKSDVPATAGHELTGIYGLEIRTLTAAINAGILPKATGTAKFVESAVRNEGITAPVLIMKGDGGVTSMRTFQSKPIITVLSGPAASVAGALLHLRVIDGVFIEVGGTSTNVCVIKDGRPEIRYVTITQHPTCIRSLDVRVAGVAGGSLVRWSGRKITDVGPRSAHIAGLPYSCFAQPDELEGGQIITFSPKEGDPIDYVAIEAGGKRFAITNTCAANALGLVPKGDYAYANVESAKTALSILASRIGTTMEQAAGMILDISAKKVLDIVEPMVKEYKLKRERIVFVGGGGGASVLVPYVARKMQLSHKIAEHAEVISSIGVAAAMIHEEVEKTVSNPKPEDITELAEQVKKTALERGALPESITIQSEFISERSLLRVTAMGNVSLDIGTANAPEIGDSEAHVLACELFGVNEGVQRIFDMKNYHIFACEMSKKKLFLKSKKQPVLVLDKYGRVRLSVDNAAIFNGAPDDVADRVDELLHEHRDSGKDLAPQVHILDGVKLMDFSSLTAPEHVAKAVRDELKKAAAKDVAAIVRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MV39</accession>
    <name>A0A075MV39_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03076</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MV39"/>
    <dbReference type="KEGG" id="nev:NTE_03076"/>
    <dbReference type="HOGENOM" id="CLU_2730147_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="71" mass="7806" checksum="64453416347F5AED" modified="2014-10-29" version="1">MLALPVYQVPVRPGQPVLANLFLLRLCSLHRFKLPSSCISPYYCNGGPLTIIVPNNPIMLVVVAYSFVCTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MV40</accession>
    <name>A0A075MV40_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Universal stress protein UspA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_03493</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701906.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MV40"/>
    <dbReference type="STRING" id="1459636.NTE_03493"/>
    <dbReference type="GeneID" id="41599118"/>
    <dbReference type="KEGG" id="nev:NTE_03493"/>
    <dbReference type="eggNOG" id="arCOG02053">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049301_16_2_2"/>
    <dbReference type="OrthoDB" id="105697at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00293">
        <property type="entry name" value="USP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46268">
        <property type="entry name" value="STRESS RESPONSE PROTEIN NHAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46268:SF6">
        <property type="entry name" value="UNIVERSAL STRESS PROTEIN UP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UspA" evidence="2">
        <location>
            <begin position="8"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF85521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="154" mass="16120" checksum="E2E86BE950E65A32" modified="2014-10-29" version="1">MEGNVAPFTKILVAVDKSEHAVRAFDYAVRLSMVTGANISVLHVVTPPVAGEEGVSAAQLADSLRKEGDHLIAQLKSRVEMQFGIRAGETTTITIDYLIKEGSPAKVIITSAKQSDADLIIVGSSGTSGVKELLLGSVSHAVSNHASCPVLIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVM5</accession>
    <name>A0A075MVM5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cation diffusion facilitator family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NTE_03261</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701721.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVM5"/>
    <dbReference type="STRING" id="1459636.NTE_03261"/>
    <dbReference type="GeneID" id="41598916"/>
    <dbReference type="KEGG" id="nev:NTE_03261"/>
    <dbReference type="eggNOG" id="arCOG01477">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013430_0_0_2"/>
    <dbReference type="OrthoDB" id="269083at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050681">
        <property type="entry name" value="CDF/SLC30A"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11562">
        <property type="entry name" value="CATION EFFLUX PROTEIN/ ZINC TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11562:SF17">
        <property type="entry name" value="RE54080P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="10">
        <location>
            <begin position="18"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="11">
        <location>
            <begin position="240"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="144"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIF85290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="322" mass="34796" checksum="C0ECCF1025D83B7D" modified="2014-10-29" version="1">MTQEERRNKLALERMKKLKIVLALTSGYLVAEVVGGFLTNSLALLADAGHMLTDVGGLTLALFAVSYARRPATPQRTYGFYRMEILASLANSIVLILLSIYILYEAYRRIFEPPEIQSLSMTIVAAVGLGVNLAGLRLMSGGGGSDGSGGHGHDVHDHHHHSSDQHGQEEEKSLNIEGARLELLSDTLGSIGVIAAGAVIMATGFYLADPIVSIGLAVFILPRTWSLLKKSIHILMEGVPSNISYEEVKNAILQVRGVTGIFDMHIWTITSGINALSAHVVVIDTGRSHAILQEINSLLEKRFKITHATIQIEGYHSESGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVN1</accession>
    <name>A0A075MVN1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385627.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVN1"/>
    <dbReference type="GeneID" id="43502674"/>
    <dbReference type="KEGG" id="nev:NTE_03183"/>
    <dbReference type="HOGENOM" id="CLU_3039195_0_0_2"/>
    <dbReference type="OrthoDB" id="373236at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="26"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="54" mass="6575" checksum="48519A9A81A05266" modified="2014-10-29" version="1">MTFTLSKYFAGAFKAKPEKRHSKYRWPCYMCQLSFDDLQEREEHVRTVHYGEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVS8</accession>
    <name>A0A075MVS8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03219</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701682.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVS8"/>
    <dbReference type="STRING" id="1459636.NTE_03219"/>
    <dbReference type="GeneID" id="41598875"/>
    <dbReference type="KEGG" id="nev:NTE_03219"/>
    <dbReference type="eggNOG" id="arCOG05463">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124258_0_0_2"/>
    <dbReference type="OrthoDB" id="31397at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="218" mass="23533" checksum="AEDA116F4AA7BCDD" modified="2014-10-29" version="1">MSGYSEDDVRRAAELREWVMKQISDKQEELERLRATLAIIDSVLKQGSFRAAATMAPSSSTAAASEPARQTTAPAKQAATMAAPPPPRQQATAAGFDPGKEVRPLKRAKDDLLLANAEVTANSITIVPAPGIDLSVNTPPFRSFFLGRILDGMKGKDAEKAAQGAISESGAMSYKVDEDSGGAIKKITITNYRDKERMTEIFNTAAWVFTRMLEKAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVW5</accession>
    <name>A0A075MVW5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8 13">Glutamyl-tRNA reductase</fullName>
            <shortName evidence="8">GluTR</shortName>
            <ecNumber evidence="3 8 13">1.2.1.70</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hemA</name>
        <name evidence="17" type="ORF">NTE_01382</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8 13">
            <text>(S)-4-amino-5-oxopentanoate + tRNA(Glu) + NADP(+) = L-glutamyl-tRNA(Glu) + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12344"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57501"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="EC" id="1.2.1.70"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8 13">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 13">Belongs to the glutamyl-tRNA reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.70" evidence="3 8 13"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700219.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVW5"/>
    <dbReference type="STRING" id="1459636.NTE_01382"/>
    <dbReference type="GeneID" id="41597178"/>
    <dbReference type="KEGG" id="nev:NTE_01382"/>
    <dbReference type="eggNOG" id="arCOG01036">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035113_2_2_2"/>
    <dbReference type="OrthoDB" id="4562at2157"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00316"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008883">
        <property type="term" value="F:glutamyl-tRNA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019353">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process from glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05213">
        <property type="entry name" value="NAD_bind_Glutamyl_tRNA_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.30:FF:000001">
        <property type="entry name" value="Glutamyl-tRNA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000031">
        <property type="entry name" value="Glutamyl-tRNA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.30">
        <property type="entry name" value="Glutamyl-tRNA reductase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00087">
        <property type="entry name" value="Glu_tRNA_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000343">
        <property type="entry name" value="4pyrrol_synth_GluRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015896">
        <property type="entry name" value="4pyrrol_synth_GluRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015895">
        <property type="entry name" value="4pyrrol_synth_GluRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018214">
        <property type="entry name" value="GluRdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036453">
        <property type="entry name" value="GluRdtase_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036343">
        <property type="entry name" value="GluRdtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006151">
        <property type="entry name" value="Shikm_DH/Glu-tRNA_Rdtase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01035">
        <property type="entry name" value="hemA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43013">
        <property type="entry name" value="GLUTAMYL-TRNA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43013:SF1">
        <property type="entry name" value="GLUTAMYL-TRNA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00745">
        <property type="entry name" value="GlutR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05201">
        <property type="entry name" value="GlutR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01488">
        <property type="entry name" value="Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000445">
        <property type="entry name" value="4pyrrol_synth_GluRdtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69742">
        <property type="entry name" value="Glutamyl tRNA-reductase catalytic, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69075">
        <property type="entry name" value="Glutamyl tRNA-reductase dimerization domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00747">
        <property type="entry name" value="GLUTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 11" id="KW-0521">NADP</keyword>
    <keyword evidence="5 8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 8 13" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamyl-tRNA reductase N-terminal" evidence="16">
        <location>
            <begin position="24"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase" evidence="15">
        <location>
            <begin position="183"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation" evidence="14">
        <location>
            <begin position="329"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8 9">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <begin position="63"/>
            <end position="66"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <begin position="125"/>
            <end position="127"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <begin position="200"/>
            <end position="205"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for activity" evidence="8 12">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF05201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AIF83449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="442" mass="48928" checksum="7DD6149F86649022" modified="2014-10-29" version="1">MTAAIKTHDSSHFALPVQVVNARVTYKNAPIHLLEKFTFKDVEAAHRAFVDKAGVDECVILQTCNRVEVFVAAKNADEAKVMGQWAEAAGLEKKDLASVEVSTGKEAVLHLMKLASGLDSLVVGENQILGQVRRAFEYSRANRYANANLAAIFDRALKVGSRVRTATGINKGNVSIASVAVNLADEYFDDLKTKRVMLIGSGEAASLVAKVLKNSGVDFMVTSRTYERARSFSETVAGKPVPFDTALNMLGQLDLIFVASTAPYFLITYERLQEAVKGRKDAVMIFDLSNPRTVDEKVATIHGVKLINMDQIAELVEKNMRSRMKEAHAAEKMIEGEMKSVDGMMKRMKAEPVVVSVFKSVDAIRERELKKALSMLGKKAGSDDNDAKVIEQLSYAIVEGILSTPMNYLRKEIEEGDMESEELMKIVAKMFKYEDEKKQQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVW8</accession>
    <name>A0A075MVW8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03372</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVW8"/>
    <dbReference type="STRING" id="1459636.NTE_03372"/>
    <dbReference type="KEGG" id="nev:NTE_03372"/>
    <dbReference type="HOGENOM" id="CLU_586092_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="466" mass="53420" checksum="20B5E5AC159EE3E2" modified="2014-10-29" version="1">MIPEGPTSNFEIIMLSRRFYISIIEKRLVSIIMAQEDINKVRDREYRKAGLNLIKEGEHFVLPIEIPAKVEGVHGKVPFNGNGIIRIEGFTDDTAARRAGFPEWRIPGKNIPNIFTFVDDKAGPLVRIVPGNDMLGWHRAQKAGRLAKRTGVNIVWDVNELSGWAFFEAGKNNWLLEYALNKIMGWNLFDEEEAWSLLTADTLAMEWPKEQMMKINLREHFFKNPTNKLMLFRRARGRMEQDPALPLPELVGGGGAPERYWVSRYVFASSAIERHVIRHPELANLYPEWTADALATKYVRMMQKINYVPDALEAHLENQVFLADVVGNLIGLGECIDKTEPFLVLSYEHAVEGLQAFRTDRIDSPSWLNHAGGVEHINKCIEWTELLLAGKWEDAAKVEREMYETFEKYLKNGAKDTGKDFMMLWIERLPIMLMWDVLQAYVGESVRRGIWKPVNVTPLRVNASPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVY6</accession>
    <name>A0A075MVY6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">A-type ATP synthase subunit I</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NTE_03274</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the A-type ATP synthase that produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the V-ATPase 116 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701733.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVY6"/>
    <dbReference type="STRING" id="1459636.NTE_03274"/>
    <dbReference type="GeneID" id="41598929"/>
    <dbReference type="KEGG" id="nev:NTE_03274"/>
    <dbReference type="eggNOG" id="arCOG04138">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025558_0_0_2"/>
    <dbReference type="OrthoDB" id="85892at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016471">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1460.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002490">
        <property type="entry name" value="V-ATPase_116kDa_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629:SF63">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629">
        <property type="entry name" value="VACUOLAR PROTON ATPASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01496">
        <property type="entry name" value="V_ATPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="369"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="460"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="503"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="544"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="615"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="639"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="231"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00059506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00068671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIF85303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="705" mass="77193" checksum="8861DAFD2F708EC3" modified="2014-10-29" version="1">MGLAKLKKATVILPRMETQAAVSKLAELEWFHPIPSSSASEHLNPYYDDLLLKAQKLYQEIDEVIKALGIPAEAGVLATMFRGAPKGKTDYHIDNIQGFIADLEDRAAKELEGARKIIDERNRTQKSLEEYSNLKALTENASSLSMDLTRLGTLSKFYAGIYVIDSTDEAEIRKSLEDLAVYSTNLGEKKTALTIVGSAEDSERIAKVMRSFGINPLQIPANMPQNPNVAFSEASAKVKELEARMEQLDKEVVKLKESIITKVLSLREAAGMAKDVLETTRKPGGTKNFAVIEGYIPAEMEGKFKKLAGDDYVSVVEETGVTIDLQDAGKPTMPTLLSNKGYSKNFELITETQGLPRYGETDPTKIISFVWPIFYGLMFADFGHGILLFGLGMLFRIRGNGRLKMWGTLVAASGLAATVGGLGTGEMFGFHFSELAVLSGLASALPFIGLLSVAELTFDQVVKILAVSVAIGIGHLLLAFGLRLRADWRLGNKLMVYTHDIPAIIQYLAVVSLILTAIGAQYDIIGMFLSNKTYGPIPWISDVFPWVTVGMVARAAPPVIFACIAITIIGGMKEEKHLKAEGKESPHGGMVGIVVETVMVRTIEMLANTISYSRIGIMLLVHSALLVTVNNSFEHGGGLAILIGGNIGIMMIEGLIVYIQTIRLHLYEWFPKWYKSDGVTFKKLVPNMLYSNLVWKEDGSGKKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MW18</accession>
    <name>A0A075MW18_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cysteine--tRNA ligase</fullName>
            <ecNumber evidence="12">6.1.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Cysteinyl-tRNA synthetase</fullName>
            <shortName evidence="12">CysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">cysS</name>
        <name evidence="14" type="ORF">NTE_03319</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>tRNA(Cys) + L-cysteine + ATP = L-cysteinyl-tRNA(Cys) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:17773"/>
            <dbReference type="Rhea" id="RHEA-COMP:9661"/>
            <dbReference type="Rhea" id="RHEA-COMP:9679"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78517"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.16" evidence="12"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MW18"/>
    <dbReference type="STRING" id="1459636.NTE_03319"/>
    <dbReference type="KEGG" id="nev:NTE_03319"/>
    <dbReference type="eggNOG" id="arCOG00486">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013528_0_1_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006423">
        <property type="term" value="P:cysteinyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00672">
        <property type="entry name" value="CysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000009">
        <property type="entry name" value="Cysteine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1910">
        <property type="entry name" value="Cysteine-tRNA ligase, C-terminal anti-codon recognition domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00041">
        <property type="entry name" value="Cys_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015803">
        <property type="entry name" value="Cys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015273">
        <property type="entry name" value="Cys-tRNA-synt_Ia_DALR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00435">
        <property type="entry name" value="cysS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890:SF3">
        <property type="entry name" value="CYSTEINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="CYSTEINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09190">
        <property type="entry name" value="DALR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00840">
        <property type="entry name" value="DALR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 12 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Cysteinyl-tRNA synthetase class Ia DALR" evidence="13">
        <location>
            <begin position="357"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="12">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="12">
        <location>
            <begin position="269"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AIF85348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="475" mass="53349" checksum="A2DE5C6E32AF8BC1" modified="2014-10-29" version="1">MLLSSAVKLYNTLTRKVEDLKPEDDDKVRMYVCGVTVYDSSHIGHARTVIVFDVLRRYLMAKGYKVKFVQNFTDVDDKIINRAKTEGKKAEEISSKYIDAYFHDFSGLNVLAADVHPKATEHITEMINLIKGLVDKGYAYLTLNGVYFRVKKFAGYGKLSRKPVEELEAGARIEVDQSKEDPMDFALWKFSSEPPFWDSPWGKGRPGWHIECSAMALKYLGNTFEIHGGGHDLVFPHHENEIAQSESFTGAQFAKIWMHSGMVTINSQKMSKSLGNIVTIEKALERWGANTLRLYCVSVHYAKPLDYTEELLKESAQRWRQIETCAFELASAAAAGNSGDRGDADAVARMAAESEQAFDAAMDDDLNTSLALTAFLQFVTKLNQYAASDKLTGDMAKAALPAFGRIMSVLGLKVAETGAQEQKEVEEMVAARNRLRAEKKFKDADEIRKSLLARSIELMDHKGRTVWKKVERPEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWA3</accession>
    <name>A0A075MWA3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">C2H2 type zinc finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01501</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWA3"/>
    <dbReference type="KEGG" id="nev:NTE_01501"/>
    <dbReference type="eggNOG" id="arCOG06947">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_184933_0_0_2"/>
    <dbReference type="OrthoDB" id="11760at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="13"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="41"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="81" mass="9872" checksum="A4FA3E13678558B1" modified="2014-10-29" version="1">MCNNFCVLLGKKFSCDQCPARFENYDDLIKHAREVHHHAIVRCQDCGKEFIHEKDRLHHVRQEHVKKTRFRENKNLYRHDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWB3</accession>
    <name>A0A075MWB3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nickel/cobalt efflux system</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NTE_02909</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the NiCoT transporter (TC 2.A.52) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWB3"/>
    <dbReference type="KEGG" id="nev:NTE_02909"/>
    <dbReference type="eggNOG" id="arCOG06023">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036094_2_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015099">
        <property type="term" value="F:nickel cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004688">
        <property type="entry name" value="Ni/Co_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011541">
        <property type="entry name" value="Ni/Co_transpt_high_affinity"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31611">
        <property type="entry name" value="HIGH-AFFINITY NICKEL TRANSPORT PROTEIN NIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31611:SF0">
        <property type="entry name" value="HIGH-AFFINITY NICKEL TRANSPORT PROTEIN NIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03824">
        <property type="entry name" value="NicO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0533">Nickel</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="154"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF84947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="284" mass="29646" checksum="77A79D32556484FD" modified="2014-10-29" version="1">MLPQLVEGDIATFVAVSIPTMVLLGLRHALDADHITAIDNMVRLHNASRKSRWVGAGFSVGHMISVLAEMVFIIFVIGGIAGADVLAFWGGIIGAAALGTIGAINIYAMKKWGKTGSAILASKVLARTGSYNPFVSSLVTGMVFGLGFDTATQISAITLSAVASATLGVQVALTLAGFFALGMIPLDTLDSILLRSALSRIFDTKGFRYMSYALSGAAMAVAALATYENLTGAEIIPELAGPVLAGVIIAGSFGYSFAARRKAGRADLIMQKEDKTTDPHHSHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWR2</accession>
    <name>A0A075MWR2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01643</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWR2"/>
    <dbReference type="KEGG" id="nev:NTE_01643"/>
    <dbReference type="eggNOG" id="arCOG10403">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_211278_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="45" mass="5025" checksum="99FA47CBF82192E9" modified="2014-10-29" version="1">MSRARMTDGKCPKCTTIVKFKVSGDVGKEIYECTSCMSKFSIDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWW1</accession>
    <name>A0A075MWW1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">L-aspartate dehydrogenase</fullName>
            <ecNumber evidence="6">1.4.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nadX</name>
        <name evidence="9" type="ORF">NTE_01698</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-aspartate + NAD(+) + H2O = oxaloacetate + NH4(+) + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11788"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.4.1.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-aspartate + NADP(+) + H2O = oxaloacetate + NH4(+) + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11784"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.4.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; NAD(+) biosynthesis; iminoaspartate from L-aspartate (dehydrogenase route): step 1/1.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="6">The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the L-aspartate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.21" evidence="6"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700471.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWW1"/>
    <dbReference type="STRING" id="1459636.NTE_01698"/>
    <dbReference type="GeneID" id="41597468"/>
    <dbReference type="KEGG" id="nev:NTE_01698"/>
    <dbReference type="eggNOG" id="arCOG00254">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089550_0_0_2"/>
    <dbReference type="OrthoDB" id="15415at2157"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00456"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033735">
        <property type="term" value="F:aspartate dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016639">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01265">
        <property type="entry name" value="NadX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005106">
        <property type="entry name" value="Asp/hSer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002811">
        <property type="entry name" value="Asp_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022487">
        <property type="entry name" value="Asp_DH_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020626">
        <property type="entry name" value="Asp_DH_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011182">
        <property type="entry name" value="L-Asp_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03855">
        <property type="entry name" value="NAD_NadX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009828">
        <property type="entry name" value="PRK13303.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009829">
        <property type="entry name" value="PRK13303.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009830">
        <property type="entry name" value="PRK13304.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31873:SF6">
        <property type="entry name" value="ASPARTATE DEHYDROGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31873">
        <property type="entry name" value="L-ASPARTATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01958">
        <property type="entry name" value="Asp_DH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03447">
        <property type="entry name" value="NAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005227">
        <property type="entry name" value="Asp_dh_NAD_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0520">NAD</keyword>
    <keyword evidence="3 6" id="KW-0521">NADP</keyword>
    <keyword evidence="4 6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 6" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aspartate/homoserine dehydrogenase NAD-binding" evidence="8">
        <location>
            <begin position="10"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Aspartate dehydrogenase" evidence="7">
        <location>
            <begin position="173"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF83759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="276" mass="29277" checksum="2217D89A21231B18" modified="2014-10-29" version="1">MPARKVGIIGCGTIGSQLAIAVDTGAVRNASLVSLFDVVQNSAQVLKQKLNTGPSAYSSFDDFIKKTDCDIVVEAASQEAVKRFAVQVLRAEKDLMVMSVGALADKTFLSELLREAEKAGRRLYVPTGAIAGIDAIRAVKHLLDSVTLATTKSPKALAGAPFFETSKVKLDEIKERTVIYEGTAADAVRAFPANVNVAAVLSLAGIGVDRTKVRIIADPAFTTNQHEITAKGSFGEFRFTVNNVPSPGNPKTSYLAVLSAIECLRSICDDGMRVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWX0</accession>
    <name>A0A075MWX0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aspartate-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="4">1.2.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">NTE_03113</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SR1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 2/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 2/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the aspartate-semialdehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.11" evidence="4"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701592.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWX0"/>
    <dbReference type="STRING" id="1459636.NTE_03113"/>
    <dbReference type="GeneID" id="41598773"/>
    <dbReference type="KEGG" id="nev:NTE_03113"/>
    <dbReference type="eggNOG" id="arCOG00494">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049966_1_0_2"/>
    <dbReference type="OrthoDB" id="38238at2157"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00016"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00463"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00464"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004073">
        <property type="term" value="F:aspartate-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
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        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
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        <property type="entry name" value="ASADH_C_arch_fung_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ScASADH_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Probable aspartate-semialdehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ASADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000319">
        <property type="entry name" value="Asp-semialdehyde_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005676">
        <property type="entry name" value="Asp_semi-ald_DH_pep-lack"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00978">
        <property type="entry name" value="asd_EA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006416">
        <property type="entry name" value="PRK08664.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46718">
        <property type="entry name" value="ASPARTATE-SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46718:SF1">
        <property type="entry name" value="ASPARTATE-SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000148">
        <property type="entry name" value="ASA_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01103">
        <property type="entry name" value="ASD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="10" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="11" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Semialdehyde dehydrogenase NAD-binding" evidence="13">
        <location>
            <begin position="3"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="12">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000148-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AIF85147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="358" mass="39152" checksum="C31AA1A55913E045" modified="2014-10-29" version="1">MLKVAVIGATGAVGQEFVVALNKHKWFQLTQVAASERSAGKKYVDALRDPNSGILKWHNREEVPEYVKNMTVSKVDDIKPENFDLIFTALESDDAKIIEPKFAKTTPVISTAAAFRYESDVPILIPGVNDDQADLLKAQGKNRGWKGFVAPLPNCTTTGLAITLKPVLDKFGINKVIMTSMQALSGAGRSPGVIALDITDNVIPYIPKEEEKVQVEAKKILGKFAKNAITPADFRVSCTCTRVPVLDGHTETVFVETAEAAEPEDVKKEMLKFSKGVSIGKLPSAPKEYIVVHDDPTRPQPRIDRELNDGMTTAVGRLRKDTAFDNGIKYVLLSHNEKMGSAKGAVLLAELLKDKQIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MXA0</accession>
    <name>A0A075MXA0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CBS-domain-containing membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_01869</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700611.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MXA0"/>
    <dbReference type="STRING" id="1459636.NTE_01869"/>
    <dbReference type="GeneID" id="99755942"/>
    <dbReference type="KEGG" id="nev:NTE_01869"/>
    <dbReference type="eggNOG" id="arCOG00606">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2327136_0_0_2"/>
    <dbReference type="OrthoDB" id="9280at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051257">
        <property type="entry name" value="Diverse_CBS-Domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43080:SF2">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43080">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN CBSX3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF83929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="98" mass="10695" checksum="D003205A52F60171" modified="2014-10-29" version="1">MSSPLVTIGEDASVRNAIALMQSKQIRRLPVISSDGSVIGIVTLKTIIGNMPSHNIDLAELESSRSVAQRESVCPYCRSVIGKSETMVGHMEDTHMRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MXI9</accession>
    <name>A0A075MXI9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hydrocarbon binding protein (Contains V4R domain)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01961</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700676.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MXI9"/>
    <dbReference type="STRING" id="1459636.NTE_01961"/>
    <dbReference type="GeneID" id="41597709"/>
    <dbReference type="KEGG" id="nev:NTE_01961"/>
    <dbReference type="eggNOG" id="arCOG01688">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105305_0_0_2"/>
    <dbReference type="OrthoDB" id="8995at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004096">
        <property type="entry name" value="V4R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35090">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35090:SF1">
        <property type="entry name" value="SLR0144 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02830">
        <property type="entry name" value="V4R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00989">
        <property type="entry name" value="V4R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4-vinyl reductase 4VR" evidence="1">
        <location>
            <begin position="129"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="196" mass="21574" checksum="6D95367455DDC5DC" modified="2014-10-29" version="1">MKSLRDLRERKDDSDAAATTTGLSNPYFHFDPQSKQIKDSVFNCRGIIINERFWNRIRDELMELTKEAGPVILYQLGLSYGLEVGIQGKEAVKDSVAAIDFLEYYGLLAGWGRFETSKLQLSQGQLNGSAVVKIFDNFFAHAPQNSSGNPSCFFVAGLLAGITDGLFGGHHNCLEEQCISAGSKCCQFVVARASSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MXM2</accession>
    <name>A0A075MXM2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01991</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700699.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MXM2"/>
    <dbReference type="STRING" id="1459636.NTE_01991"/>
    <dbReference type="GeneID" id="41597738"/>
    <dbReference type="KEGG" id="nev:NTE_01991"/>
    <dbReference type="HOGENOM" id="CLU_1745472_0_0_2"/>
    <dbReference type="OrthoDB" id="14313at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="149" mass="16991" checksum="9498B20A1F57552F" modified="2014-10-29" version="1">MAGKLSKKQPIDDKATASTCCSFSQPIKDTLNRDQWEPAIVASKVRNVIHITAYDRRNDANNILYRPYDYYCYNDSFVSRSSQEGWFNQQISSVDSANKQTSGNTWFLDDYHGIATSTVREAYTVWTDSRNINGTNAANFDIYSDRTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MXM9</accession>
    <name>A0A075MXM9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03338</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MXM9"/>
    <dbReference type="STRING" id="1459636.NTE_03338"/>
    <dbReference type="KEGG" id="nev:NTE_03338"/>
    <dbReference type="HOGENOM" id="CLU_2392998_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="94" mass="10609" checksum="7091A36C809681D4" modified="2014-10-29" version="1">MWRLVKYLEENNSEVLSRKELVQKLCEIWPSGDNSSTPARDHEELAAAVASALWLGRRAQQIKESGDKSAEQFFREAIMVAFETGRRSAITTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MY30</accession>
    <name>A0A075MY30_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="2">1.2.1.88</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NTE_03539</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-glutamate 5-semialdehyde + NAD(+) + H2O = L-glutamate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:30235"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="EC" id="1.2.1.88"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.88" evidence="2"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MY30"/>
    <dbReference type="STRING" id="1459636.NTE_03539"/>
    <dbReference type="KEGG" id="nev:NTE_03539"/>
    <dbReference type="eggNOG" id="arCOG01252">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_0_0_2"/>
    <dbReference type="OrthoDB" id="6342at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003842">
        <property type="term" value="F:L-glutamate gamma-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:L-proline catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000005">
        <property type="entry name" value="1-pyrroline-5-carboxylate dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050485">
        <property type="entry name" value="Proline_metab_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42862">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42862:SF1">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3 7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="8">
        <location>
            <begin position="52"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF85567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="527" mass="57813" checksum="F7ECF800F6F299EC" modified="2014-10-29" version="1">MFENEHTLRRFMVEKAEGQFHDRYERALEAARSEFGKKYPMIIAGKQVLAAKTVPHASPIDTRVVLGYMPAGTATHARQAIASAKKAFEGERDGGWGKSEWQERVKIFRKAADIMSERKFELAAWVSYENGKNRYEAIGDVDEAIDFVRYYAEEVERNNGFEVPMKSAQPNEKSKSVMKPYGVWGVIAPFNFPAAILTGMTTAALVTGNTVVVKPSSDAPITAFKIVQIFQEAGLPAGVLNMVFGSGGTVGAEIVKSRDVSGIVFTGSREVGYSMGRQFSSKKPRPLIAELGGKNPAIITETADLDKAVDGVVKAAFGYSGQKCSACSRVFVHKKVKDEFLHRLVEKTKNLPVGNPLEQNTFMGPVVNEGAYKKYQQYARLAGRDGKVLAGGQVRKDGELKHGYYVAPTIVTGLPKKHRLFREEMFVPILCVTDYEKFDDALSMANDVDYGLTAGIFTGDQGEVKRFLDHVEAGVVYVNRQASATTGAMVGCQPFGGWKDSGTTGKNTGGPHYLTQFMREQSQTISD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MYX9</accession>
    <name>A0A075MYX9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02414</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MYX9"/>
    <dbReference type="KEGG" id="nev:NTE_02414"/>
    <dbReference type="HOGENOM" id="CLU_2534506_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="83" mass="9487" checksum="1881EBBD15E1869C" modified="2014-10-29" version="1">MSFISLHSGFSIHIFCLNLMQSFSLIIDSFSNLLPSWLITKPSKFLSFSPLIADFTIRSLMRFCSFRFRPMFAASAGVWPPMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MZH1</accession>
    <name>A0A075MZH1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydrofolate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02606</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701182.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MZH1"/>
    <dbReference type="STRING" id="1459636.NTE_02606"/>
    <dbReference type="GeneID" id="41598299"/>
    <dbReference type="KEGG" id="nev:NTE_02606"/>
    <dbReference type="eggNOG" id="arCOG01490">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043966_4_2_2"/>
    <dbReference type="OrthoDB" id="7348at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="entry name" value="Dihydrofolate Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050765">
        <property type="entry name" value="Riboflavin_Biosynth_HTPR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38011:SF11">
        <property type="entry name" value="2,5-DIAMINO-6-RIBOSYLAMINO-4(3H)-PYRIMIDINONE 5'-PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38011">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_8G06820)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="Dihydrofolate reductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bacterial bifunctional deaminase-reductase C-terminal" evidence="1">
        <location>
            <begin position="76"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="170" mass="19426" checksum="7190C2DC24AAD760" modified="2014-10-29" version="1">MRKVKLFIASSLDCYIARNDGSVDWLFTDGDYGYAKFYDSIDTVIMGRKTYETALKFEEHPYKDKKCYVFTRNPSEKYRNVEFVSDVVGVTKSLVRSTEGRDIWLVGGAEINSVLLDAGLIHEIIVAVHPTILGRGIPMFNNVKQANMKLVDLIRYDNGLVQMHYQLMPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MZT5</accession>
    <name>A0A075MZT5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NTE_02702</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701261.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MZT5"/>
    <dbReference type="STRING" id="1459636.NTE_02702"/>
    <dbReference type="GeneID" id="41598391"/>
    <dbReference type="KEGG" id="nev:NTE_02702"/>
    <dbReference type="eggNOG" id="arCOG04548">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_178207_0_0_2"/>
    <dbReference type="OrthoDB" id="23833at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050572">
        <property type="entry name" value="Fe-S_Ferredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43687">
        <property type="entry name" value="ADENYLYLSULFATE REDUCTASE, BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43687:SF6">
        <property type="entry name" value="L-ASPARTATE SEMIALDEHYDE SULFURTRANSFERASE IRON-SULFUR SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13237">
        <property type="entry name" value="Fer4_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="35"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="68"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF84744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="103" mass="11580" checksum="2B8E62010F28097F" modified="2014-10-29" version="1">MPIDPDFQAHRHPEESYGNLKVWRDNKGTLGIYGTSVTVDFDLCVGDGACIDVCPADVFEWHGEGAERKAMPERERDCTYCFGCEAVCPKFAIRVTIPLQVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N0S3</accession>
    <name>A0A075N0S3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein eS6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rps6e</name>
        <name evidence="6" type="ORF">NTE_03034</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N0S3"/>
    <dbReference type="STRING" id="1459636.NTE_03034"/>
    <dbReference type="GeneID" id="41598703"/>
    <dbReference type="KEGG" id="nev:NTE_03034"/>
    <dbReference type="eggNOG" id="arCOG01946">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109671_1_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00512">
        <property type="entry name" value="Ribosomal_eS6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001377">
        <property type="entry name" value="Ribosomal_eS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020924">
        <property type="entry name" value="Ribosomal_eS6_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018282">
        <property type="entry name" value="Ribosomal_eS6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11502">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01092">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01405">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00578">
        <property type="entry name" value="RIBOSOMAL_S6E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="172"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF85069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="197" mass="21480" checksum="F2BABA288C8D2B97" modified="2014-10-29" version="1">MSYMEFLSLLSRTFGYTRNIKILDCMLNVPASEFTKRELRQLSQRLIKSKRRLDSAMAQFKLVISDSTGRSVSQELKDRAAQPLLGARIGSVLDSSVIGITGGKVKITGGSDKAGTPMRSDVHGGVKKYVLMSEGVGAKNLEGGRIRKLVRGNMVTEEIYQLNVSLVEGKLPEKPKEEAPAAAAEAVAPAKEEKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N1Q8</accession>
    <name>A0A075N1Q8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03366</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701807.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N1Q8"/>
    <dbReference type="GeneID" id="41599012"/>
    <dbReference type="KEGG" id="nev:NTE_03366"/>
    <dbReference type="HOGENOM" id="CLU_975212_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="285" mass="30560" checksum="ABB9F0B1A001EBD1" modified="2014-10-29" version="1">MKKLATVSVMFAFLLILAVQPAYAVSITGTTKSGGVGLGDAKVTAERVGEYAWTRTATSGTVGSYTLTVGSTNSYTVASAKTSYTRASATVNGGSAAPDLNLSTRSQTNIIFKIAFDTSAGSGLTIDQARFYLYQAEPWYLDEHSIDFQETGAGTAWSTAGTADNFCYTTFLNDMKNDVNWNSGNYGIAEILIGFTGKQMPDANGCINAVPTAGGTHPYIMVSNWSPDIARTVMHEVTHAYGMDHVTSCLNQIPGIMASSCGDSLYIKNWVPDDDTTMESHRSWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N218</accession>
    <name>A0A075N218_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03466</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701891.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N218"/>
    <dbReference type="GeneID" id="41599100"/>
    <dbReference type="KEGG" id="nev:NTE_03466"/>
    <dbReference type="HOGENOM" id="CLU_114820_0_0_2"/>
    <dbReference type="OrthoDB" id="5955at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="186" mass="21060" checksum="D042D4504276A2EC" modified="2014-10-29" version="1">MTSGQYFNKGVKALDSPHVGHVVRETDDKIVVFGGGDDRYDIPKSEIKFTSGNVLIDLPMYEIAKKYRVSREEPLPTGKATKDPWTRPENVDLASYEREYPKSLFNKGVRTNNADHVGHVVKETDDKIVVFGHFDYRFDIPKSEIVAAGRNVIVKPDFPEILKYRVDRNAPLPTGEPIDKLAEEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLF0</accession>
    <name>A0A075MLF0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00174</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="38" mass="4188" checksum="7C2DE8FBB85CE167" modified="2014-10-29" version="1">MTVDQELENTIIYKCSECGLSNSILKDNHSSTTAVDRA</sequence>
</entry>
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        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="Pfam" id="PF02697">
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    </dbReference>
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        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="77" mass="8808" checksum="FA2136FB0EA178F7" modified="2014-10-29" version="1">MPTRTLSITEEAYMALKASKKEGESFTDVILRLTGNKGSAKRLLEMMDEMHSPELADNIEQASKEFRKNFKTRDVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMT3</accession>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
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            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
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    </dbReference>
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        <location>
            <begin position="12"/>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="93"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="217" mass="22830" checksum="B482B101C54FE5BD" modified="2014-10-29" version="1">MSTGRLVEIELAAINLVGLAISAMIGRFAYSGYATIGSPNLLRLTLAFVSIAAGFALIIGSLFASPDSAHAIDTAGLAAQAVGYFFIAMSHGLKSSFDFAPQRSAALALIPLAASPFVIPGNSIEHIIRSISFILLVYVSIETLASYMQSMRTNTLMIGSGLGTLAVAELLAWYDFIFPGTFIYPAMAAKVAGFGLMFIPFSKFGLTSGLGRLKENA</sequence>
</entry>
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    <accession>A0A075MMU7</accession>
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        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
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            <dbReference type="PubMed" id="24999826"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
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    </reference>
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    <dbReference type="GeneID" id="43502558"/>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="AIF82480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="51" mass="5917" checksum="F0B68E3833AE6E69" modified="2014-10-29" version="1">MSYSDNRNEVFISKRRIDTTSNYVIEQTDVSLKSKDLSIDELIKKAKEAVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMW4</accession>
    <name>A0A075MMW4_9ARCH</name>
    <protein>
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    </protein>
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        <name evidence="2" type="ORF">NTE_00418</name>
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    <organism evidence="2 3">
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
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                <person name="Daroub S.H."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
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    <dbReference type="GO" id="GO:0008728">
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR052194">
        <property type="entry name" value="MESH1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46246">
        <property type="entry name" value="GUANOSINE-3',5'-BIS(DIPHOSPHATE) 3'-PYROPHOSPHOHYDROLASE MESH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46246:SF1">
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    </dbReference>
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    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
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        <location>
            <begin position="48"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="197" mass="22321" checksum="9E3CEFC5A6BA2B64" modified="2014-10-29" version="1">MEQSFDDFTKAGFARLLKHFEGNTDEVVKLTRAFALATKAHKGHVIDNKEPHVNHSLRTALILSEELQMRDVDIASAALLHDALEGVQEQEVREECGDRVAEMVRAVAEPRPTRQQQGDERDKILGEYFAKLAKSPKEARCVKLADRLDTARSMKNHAYRDSALRFKEEAQRHAVPLAQATDERLAFKLSVALYEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMY3</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    <gene>
        <name evidence="2" type="ORF">NTE_00738</name>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_193354087.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMY3"/>
    <dbReference type="STRING" id="1459636.NTE_00738"/>
    <dbReference type="GeneID" id="41596590"/>
    <dbReference type="KEGG" id="nev:NTE_00738"/>
    <dbReference type="eggNOG" id="arCOG10856">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117038_0_0_2"/>
    <dbReference type="OrthoDB" id="10607at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="205" mass="21619" checksum="E7E382C1925D72E3" modified="2014-10-29" version="1">MRGEALGRNSSSVWSNRFIASAIIQGAAITLLTASFVGMQFLFSSSVNIIQILSLSFEGPAKWIFLGYILYMILIVAIATTAIFYNHLEVNLQKRIRGVRSALAWTNLVGMNVGGAAVTLMMVYAGLAGSGVLGMIAGGGGANAGLTENPAVMDQFIIPIAAFAVLLIIGVIAGGLAYIATYFQKKPSVSYDDSNNIDMEKIGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNB2</accession>
    <name>A0A075MNB2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NTE_00564</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699573.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNB2"/>
    <dbReference type="STRING" id="1459636.NTE_00564"/>
    <dbReference type="GeneID" id="41596430"/>
    <dbReference type="KEGG" id="nev:NTE_00564"/>
    <dbReference type="eggNOG" id="ENOG502N5BN">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087059_1_0_2"/>
    <dbReference type="OrthoDB" id="11980at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039020">
        <property type="entry name" value="PaxB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42038">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42038:SF2">
        <property type="entry name" value="TERPENE CYCLASE AUSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25129">
        <property type="entry name" value="Pyr4-TMTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF82645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="224" mass="25868" checksum="57F22BFB0D140E32" modified="2014-10-29" version="1">MYTELMVAGGVFWSITYVLIIRQGFKDKTFGMPLAALCANISWEAIFSMLHPVSPPQLYINYAWFALDAIIVFQFLKYGKKEFFPKFSTAQFYLAFSFGLVMAFFAVLFVTYEFEDWHGAYAAFAQNLMMSVLFIWMFFSRSSDDNSSNSLRGQSFYIALFKMLGTGVSSLAFYLYQPISHGSFLMTYLYVSIFVCDVIYTGLVYQRSRQQKISLLFFGQLLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNE2</accession>
    <name>A0A075MNE2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">YVTN family beta-propeller repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00997</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699910.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNE2"/>
    <dbReference type="STRING" id="1459636.NTE_00997"/>
    <dbReference type="GeneID" id="41596825"/>
    <dbReference type="KEGG" id="nev:NTE_00997"/>
    <dbReference type="eggNOG" id="arCOG02560">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_648299_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051200">
        <property type="entry name" value="Host-pathogen_enzymatic-act"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47197:SF3">
        <property type="entry name" value="DIHYDRO-HEME D1 DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47197">
        <property type="entry name" value="PROTEIN NIRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="423" mass="46035" checksum="DA48F3DF3653B1FA" modified="2014-10-29" version="1">MSKAALELAVSAAALILLSTSAVLHPPSFPYGRVVAFADDSEDDKIEHSKDEKTNFSSPTFDSSQVVKSTLLDNDKMKYEEVANADGNFPFLVPVGMAYDSETREMYVASSATHSVVVMDATTDTAIDVIPIAERNDTFSFAGPLGLAYDPAMGYIFAANAPYGKVSVISDSDHKIVGEIKISGELGRLAVDTDHNKVYVVNSGTISVVDDETLEVIDNIKLRDGTFMTDIVYDPDDEKMYVAMFGGSYAGAGIAVIDTNTHDVIATVSTYDNVPSNIALDSHYPRVYVTSLSGEVFVISTDNYKITDTIRIPDTPYGYRHDPSTQKVVVYGNFTERIEQMTGKEELLSSSPTAIVFNPDNNYLYVVHYGVGVLSVIDTESLTVIDNISTLPGSHDIAYDPDNHSIYQTHESMNSISILSIEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNG1</accession>
    <name>A0A075MNG1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dodecin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699610.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNG1"/>
    <dbReference type="STRING" id="1459636.NTE_00610"/>
    <dbReference type="GeneID" id="41596473"/>
    <dbReference type="KEGG" id="nev:NTE_00610"/>
    <dbReference type="eggNOG" id="arCOG04561">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_161196_3_1_2"/>
    <dbReference type="OrthoDB" id="187186at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1660.10">
        <property type="entry name" value="Flavin-binding protein dodecin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009923">
        <property type="entry name" value="Dodecin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025543">
        <property type="entry name" value="Dodecin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036694">
        <property type="entry name" value="Dodecin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39324">
        <property type="entry name" value="CALCIUM DODECIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39324:SF1">
        <property type="entry name" value="CALCIUM DODECIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07311">
        <property type="entry name" value="Dodecin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89807">
        <property type="entry name" value="Dodecin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="69" mass="7853" checksum="C83C9B21E1D0862E" modified="2014-10-29" version="1">MVFKYIDILGESTKSFEDAVQNAITETAKTVKDIRTAEVMKMNAIVNSDKIVEYQAVVRVAFRVRRKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNS3</accession>
    <name>A0A075MNS3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNS3"/>
    <dbReference type="STRING" id="1459636.NTE_00380"/>
    <dbReference type="KEGG" id="nev:NTE_00380"/>
    <dbReference type="HOGENOM" id="CLU_3038862_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="54" mass="5931" checksum="9E2F45C690328CB9" modified="2014-10-29" version="1">MLLKKADVNRLENACAIADTATLKDSIIMGRIHPLSKADDEKQYAAHTITSAFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNU1</accession>
    <name>A0A075MNU1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNU1"/>
    <dbReference type="STRING" id="1459636.NTE_00720"/>
    <dbReference type="KEGG" id="nev:NTE_00720"/>
    <dbReference type="HOGENOM" id="CLU_2257227_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="103" mass="11035" checksum="BD23854789A0501E" modified="2014-10-29" version="1">MVESWLDLVSAILIFFAAIIPAYLSLKLNGNIQKMTVALTAFLFSHGIYHVVRMQGLESMADGFFEPASIVVLIAFGITYIGITSLSSSSSATSRKKGTSTGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MP24</accession>
    <name>A0A075MP24_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Polyphosphate:AMP phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_00470</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699502.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MP24"/>
    <dbReference type="STRING" id="1459636.NTE_00470"/>
    <dbReference type="GeneID" id="41596345"/>
    <dbReference type="KEGG" id="nev:NTE_00470"/>
    <dbReference type="eggNOG" id="arCOG03575">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048699_1_0_2"/>
    <dbReference type="OrthoDB" id="9408at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008976">
        <property type="term" value="F:polyphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006797">
        <property type="term" value="P:polyphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016898">
        <property type="entry name" value="Polyphosphate_phosphotransfera"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050038">
        <property type="entry name" value="PPK2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022300">
        <property type="entry name" value="PPK2-rel_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022488">
        <property type="entry name" value="PPK2-related"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF042973">
        <property type="entry name" value="ADPpolyPPhtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03709">
        <property type="entry name" value="PPK2_rel_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34383:SF3">
        <property type="entry name" value="POLYPHOSPHATE:AMP PHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34383">
        <property type="entry name" value="POLYPHOSPHATE:AMP PHOSPHOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03976">
        <property type="entry name" value="PPK2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028756">
        <property type="entry name" value="PPK2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Polyphosphate kinase-2-related" evidence="3">
        <location>
            <begin position="33"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Polyphosphate kinase-2-related" evidence="3">
        <location>
            <begin position="164"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF82552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="303" mass="35496" checksum="31095FCBACBAF155" modified="2014-10-29" version="1">MKINSEDFIVSTAGRKKVNLKHRPTIVKPLYGSKKQYKEILNEHIEELSSLQELLFASNRYSLLVIFEGMDAAGKDSAIKHVMSGVNPQGCQVFSFKRPTPIELQHDFLWRYVVCLPERGRIGIFNRSYYEGVLAARVHPEVDLRSEGFLDQDDGPAADEEKKKEEVWEQRYESIVNLEKHLYHNGTRIIKIFLHLSEEEQRKRFLERIDDPKRNWKFSLADVEERKFWHDYMKAYEDCLSATSTTTYAPWYVVPADNKENARLIISEIILETLNGLEMSYPKLDPKRLDELQSTRKKLLLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPA5</accession>
    <name>A0A075MPA5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative zinc-or iron-chelating domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01308</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPA5"/>
    <dbReference type="STRING" id="1459636.NTE_01308"/>
    <dbReference type="KEGG" id="nev:NTE_01308"/>
    <dbReference type="eggNOG" id="arCOG02579">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076511_0_0_2"/>
    <dbReference type="OrthoDB" id="36424at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005358">
        <property type="entry name" value="Puta_zinc/iron-chelating_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35866">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35866:SF2">
        <property type="entry name" value="YKGJ FAMILY CYSTEINE CLUSTER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03692">
        <property type="entry name" value="CxxCxxCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="227" mass="26266" checksum="6D9FB5C549C0E289" modified="2014-10-29" version="1">MLVKKWPVDKRLYDMQVGMRDDIVDNQVNVGGIVFHVPALSRDGLYVLWKCLWPDCHNCCERQGRLPLTKDDITIIAKKLGYDSKVEFVRSEARISSWQEQEAFGNVITTLSMLSLKRKKDEREEQDGTPLRCRFLDDKGYCGIHPEKPGVCWLYPFASWLESDRFGKPVVHATFQFTGDCPGFYLEKSLDSIMPVLQEYAPKIYSYNMAVQRTTRENYGFINFVNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPE6</accession>
    <name>A0A075MPE6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01014</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPE6"/>
    <dbReference type="STRING" id="1459636.NTE_01014"/>
    <dbReference type="KEGG" id="nev:NTE_01014"/>
    <dbReference type="eggNOG" id="arCOG10527">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1665401_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="156" mass="17559" checksum="ACE36062427E2C5D" modified="2014-10-29" version="1">MDDFRANVAQNRDALLAIAKKNPHMAYQKVNELALFVGSRHGVNLQLHFPVPAKVADVDAYGTENIGIVVDKFRRTFPVAREIVKHKAVEILGPDARALDAYMYEGKEGVKVIMTESSRIEVLPGSVHLWCRVDDERVKKYADWLMENVYFVSASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPF6</accession>
    <name>A0A075MPF6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_01024</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699928.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPF6"/>
    <dbReference type="STRING" id="1459636.NTE_01024"/>
    <dbReference type="GeneID" id="41596847"/>
    <dbReference type="KEGG" id="nev:NTE_01024"/>
    <dbReference type="eggNOG" id="arCOG03788">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1478961_0_0_2"/>
    <dbReference type="OrthoDB" id="11725at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117070">
        <property type="entry name" value="LEA14-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF83098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="198" mass="20622" checksum="1A8B3FADE7EC9A31" modified="2014-10-29" version="1">MNTKAIYAAGGGIAVAAVIVFFVLGANNNSQLPGISNSNNNNQGANSTGGASGSSSNAPNIMPPVINVKDIAVKKAGDSHANVQVTFTVKNPNNTTMILETIHYNVNVDGLRMTIGDVGQSAQGFLDSQSNLFPIVSGSTLTAKDTQTVERNSAIAGAWDKMVAGNTTFTVDGTYSYRLTAANLQTTAEDRDFSLTFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPG1</accession>
    <name>A0A075MPG1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01029</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699933.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPG1"/>
    <dbReference type="STRING" id="1459636.NTE_01029"/>
    <dbReference type="GeneID" id="41596852"/>
    <dbReference type="KEGG" id="nev:NTE_01029"/>
    <dbReference type="eggNOG" id="arCOG08770">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1248320_0_0_2"/>
    <dbReference type="OrthoDB" id="6552at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="225" mass="24974" checksum="9BB68AC571B82844" modified="2014-10-29" version="1">MKDGKSNIAIFDTFKTRRNKFTGEAKRQRGIIAHLATEQSPELRTRTSIAHAIAEQHGILWQNIYSGIFRDLDEVLIPAGVVKEGGRLPLRRGPKALQLEGVPFYELTDTGLLVASSIEELGDKRMGLLKSYVSSLPANDSQCKAMKDGLLLLIDRAPSFVTKVINEYIYAYSTGLISSIAPLETKKLRSVIAKEIAVEKELVEAFVAFSGDQKDLARNFFKVMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPL4</accession>
    <name>A0A075MPL4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA topoisomerase (ATP-hydrolyzing)</fullName>
            <ecNumber evidence="4">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">NTE_01080</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the TOP6A family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="4"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPL4"/>
    <dbReference type="STRING" id="1459636.NTE_01080"/>
    <dbReference type="KEGG" id="nev:NTE_01080"/>
    <dbReference type="eggNOG" id="arCOG04143">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037229_1_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00223">
        <property type="entry name" value="TOPRIM_TopoIIB_SPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002815">
        <property type="entry name" value="Spo11/TopoVI_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013049">
        <property type="entry name" value="Spo11/TopoVI_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036078">
        <property type="entry name" value="Spo11/TopoVI_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004085">
        <property type="entry name" value="TopoVI_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034136">
        <property type="entry name" value="TOPRIM_Topo6A/Spo11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10848">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN SPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10848:SF0">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN SPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21180">
        <property type="entry name" value="TOP6A-Spo11_Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04406">
        <property type="entry name" value="TP6A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01550">
        <property type="entry name" value="TOP6AFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01552">
        <property type="entry name" value="TPISMRASE6A"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56726">
        <property type="entry name" value="DNA topoisomerase IV, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52041">
        <property type="entry name" value="TOPO_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 10 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Spo11/DNA topoisomerase VI subunit A N-terminal" evidence="11">
        <location>
            <begin position="62"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Topoisomerase 6 subunit A/Spo11 TOPRIM" evidence="12">
        <location>
            <begin position="182"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="10">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF21180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIF83153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="357" mass="40542" checksum="7A6A0AA31DA7F010" modified="2014-10-29" version="1">MKKIGLIMKDVSTDLMVEKTMPVLDVPKVGYDNTVWSDEKRMLTIGEKTVRVSPDSTKKIPTFAQYLVMANAIRKLLDEEMESTIRGMYYATLSTVGDEKNKQKFWKGQDESDDAIKALELLTGTPREEFSVTSKPKGMISGPITLRVGGDIIDCNLGSRATSQLIPTNIRDLEIVKVKADFVMVVEKDTVLNNIRKSGFIQKYNAILLTGSGEPDRATRMMVKTLNEEWKKPVVVFADADPWGLGIALRYKIGSESLSYDSDRLVTPNAKVLGMMFSDIYEYNIPEVARLAASDEDINRANDMKKKPWFHDKQWQKELDLFLKRKEKCELDAFFKHGFKYLAEVYLPKKLREAGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPT9</accession>
    <name>A0A075MPT9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Radical SAM domain protein, CofH subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NTE_00789</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987146.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPT9"/>
    <dbReference type="STRING" id="1459636.NTE_00789"/>
    <dbReference type="GeneID" id="41596639"/>
    <dbReference type="KEGG" id="nev:NTE_00789"/>
    <dbReference type="eggNOG" id="arCOG00656">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040406_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044689">
        <property type="term" value="F:7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045567">
        <property type="entry name" value="CofH/MnqC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034405">
        <property type="entry name" value="F420"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020050">
        <property type="entry name" value="FO_synthase_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00423">
        <property type="entry name" value="CofH family radical SAM protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43076">
        <property type="entry name" value="FO SYNTHASE (COFH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43076:SF14">
        <property type="entry name" value="RADICAL SAM DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19288">
        <property type="entry name" value="CofH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004762">
        <property type="entry name" value="CHP00423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00343">
        <property type="entry name" value="aminofutalosine_synthase_(mqnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00342">
        <property type="entry name" value="cyclic_dehypoxanthine_futalosi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01064">
        <property type="entry name" value="F420__menaquinone_cofactor_bio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01389">
        <property type="entry name" value="menaquinone_synthsis_involved"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="8">
        <location>
            <begin position="59"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR004762-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR004762-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF82867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="372" mass="41294" checksum="C9236834E8243043" modified="2014-10-29" version="1">MQSIVDAFGKVGGTPALEKALAGEELSYEDGVQLMNEENLFLLGAAADKMRRDLCGNTVTFVASYYLNYTNVCAASCPLCAFYRKGNEEDAYTLSVEQIVARAKIAIEQMGATELHIVGGFHPKLGLEYYENMMHAIKSEHPKMTIKALTPAEVFFIARLTHNSVKEVLLRLKAAGLDALPGGGAEIFHPDTRKKIVIGKCSGEEWLDTARQAHELGIRSNCTMLFGHIEKPEHIVDHVIKIRELHKKTKGFTTFIPLKFSLENTELEQKEMIKSESPSPYDLRVIAVSRLLLGNTLKNVSVYWVALGKKIAQVALSYGGNDMVGTAFSEEIFKAAGKSSGTSLQELASMVREIKREPAQRDTFFNILRRFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPZ2</accession>
    <name>A0A075MPZ2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPZ2"/>
    <dbReference type="STRING" id="1459636.NTE_01170"/>
    <dbReference type="KEGG" id="nev:NTE_01170"/>
    <dbReference type="HOGENOM" id="CLU_443218_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="557"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="616" mass="69508" checksum="978CC29247F6245E" modified="2014-10-29" version="1">MIIVATLEVTIHREGNIVCIDGTKASVTFKPRDKDKTFKALIEKCALLDKGFEDKTELEYLKNSIEIQLTQIYQDYERERARKEKPKKKDLVVTREIKKLDISFEDWQKQLFEKYNKVKEKADALSPHIWPGLDFALSVKMILHIKNCTLPFFGVILGRPSSWKTFIIELFRDAAFTKYSDAFTPKAFVSHYSGFTEEELKEIDLLPKIKDSTFLTPELSPIFTKREEELTELFGIITRILDGHGYTSDSGAQGSRGYHGEYMFTWIGAGVEVPRRVHKLLGTLGPKLYFFRLKADDKSEEDYVKALILDDYPVKRNALVDAMSDYLSFFERGPAMELVAGVPKMKMENAGQDDLKLIVRLAKLLGRLRGVIPTWETSGTEGANYAYSLPTIEEPSRAITLLYNLSKGHALAQGRTCINLSDIASLINVVLSTAPVERVAIFDLLLAHDGVLTTTDITEGLNTTNPTARRTMTELKALGLVHEEQDGSNHEWKITLKEEFAWFKSDQFIALRGGHFSFSDSDNERNKPIHGSQFSFSDGSESMAERNLAYMEGQFICPLCNYDCKTYDELERHAVQKHPGKAVIAEWSMKHKQVELGGGLGKPVGETAAKEGGNKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQ05</accession>
    <name>A0A075MQ05_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700000.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQ05"/>
    <dbReference type="STRING" id="1459636.NTE_01117"/>
    <dbReference type="GeneID" id="41596931"/>
    <dbReference type="KEGG" id="nev:NTE_01117"/>
    <dbReference type="eggNOG" id="arCOG12009">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1615233_0_0_2"/>
    <dbReference type="OrthoDB" id="13356at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="164" mass="17659" checksum="5E214853080F1032" modified="2014-10-29" version="1">METSSKRTTTLAGKSPEEIAETIKNIAKNLRESSMQIRETVRTLRESGGLHEISEAVSFAAIAARDTARDINETAKELQEKGVIDNTVNAINETASATRDTVKQFKSQASKAAEDLKPAKKDLQETGKDLKEIGQSVKESVSDMPSGKQASGAGGRAKREKEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQ26</accession>
    <name>A0A075MQ26_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_01206</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700070.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQ26"/>
    <dbReference type="GeneID" id="41597015"/>
    <dbReference type="KEGG" id="nev:NTE_01206"/>
    <dbReference type="HOGENOM" id="CLU_2010006_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF83278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="123" mass="13670" checksum="1A238D121758AA3D" modified="2014-10-29" version="1">MNVEKENRRKEEVPYDEIEYQADLAKLQVNASGASSAGFGLLLSSISALVAIVTLGQINDLGKWLQFSNLYAITIILIATGMIIIAWGSGHYRKKIDKSRDRLREAKKKELESKSTPNQSTSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQ28</accession>
    <name>A0A075MQ28_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histidine--tRNA ligase</fullName>
            <ecNumber evidence="4">6.1.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Histidyl-tRNA synthetase</fullName>
            <shortName evidence="4">HisRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hisS</name>
        <name evidence="7" type="ORF">NTE_01603</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>tRNA(His) + L-histidine + ATP = L-histidyl-tRNA(His) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17313"/>
            <dbReference type="Rhea" id="RHEA-COMP:9665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78527"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.21"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.21" evidence="4"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987227.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQ28"/>
    <dbReference type="STRING" id="1459636.NTE_01603"/>
    <dbReference type="GeneID" id="41597381"/>
    <dbReference type="KEGG" id="nev:NTE_01603"/>
    <dbReference type="eggNOG" id="arCOG00404">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025113_3_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00127">
        <property type="entry name" value="His_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015807">
        <property type="entry name" value="His-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00442">
        <property type="entry name" value="hisS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43707:SF1">
        <property type="entry name" value="HISTIDINE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43707">
        <property type="entry name" value="HISTIDYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001549">
        <property type="entry name" value="His-tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="78"/>
            <end position="80"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="268"/>
            <end position="269"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001549-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF83666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="424" mass="46440" checksum="182A9D9536D43727" modified="2014-10-29" version="1">MKLELPRGMRDIESDDLAGINFVREKFFETARLFNFRMMEPSPLEMLSTLEAKSGASISNEIYAFKDKGDRDVALRFDLTIGLTRHVASRRDLKMPAKIAAFAGVWRYDEPQAGRYRYFHQWDIEVYGPFSQESDAEVIEFVSAFFKKLGLDVTIQVNDRQLVEEYIRKVLGITEEEKLLEMFRAVDKVPKKGAQGVLAEYKDAIEPAKLQSLIDFSKVTGLASEVMAKADVKGLQAWQKLSGLMDSLASRGVANATINLGIVRGLDYYSGIVFEVFDASGEGGALVGGGRYDRLTDAFGRKDIGATGAAGGIERIVLALQKHKSQTATAKALAYVAYANSDAKARALEIASTLRNAGIATDYDMLGRALRKQLDDASTKGAAVTVIVAPAELAENKVTVKSMKDGSETKQDISSIAEAVSKML</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQI7</accession>
    <name>A0A075MQI7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF2171 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01276</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700131.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQI7"/>
    <dbReference type="STRING" id="1459636.NTE_01276"/>
    <dbReference type="GeneID" id="41597080"/>
    <dbReference type="KEGG" id="nev:NTE_01276"/>
    <dbReference type="HOGENOM" id="CLU_198710_0_0_2"/>
    <dbReference type="OrthoDB" id="8303at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="76" mass="8601" checksum="9AF05BE8BE63731C" modified="2014-10-29" version="1">MSEPAILNWERVMHKNVRSHDGVDVGTIIADDADTVTIYKGSGREYKLPKTLVEGFNGAEVWLGVTYRELMSYKIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQN9</accession>
    <name>A0A075MQN9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">7-keto-8-aminopelargonate synthetase-like enzyme</fullName>
            <ecNumber evidence="6">2.3.1.29</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NTE_01790</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.29" evidence="6"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226986915.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQN9"/>
    <dbReference type="STRING" id="1459636.NTE_01790"/>
    <dbReference type="GeneID" id="41597556"/>
    <dbReference type="KEGG" id="nev:NTE_01790"/>
    <dbReference type="eggNOG" id="arCOG00113">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015846_11_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008890">
        <property type="term" value="F:glycine C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF77">
        <property type="entry name" value="8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="5">
        <location>
            <begin position="43"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF83851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="387" mass="41652" checksum="4B09E4232D3E5A7D" modified="2014-10-29" version="1">MASKQSKTLFVDEKLDALEKDGLYRSLKTVSVNGPLATVNGRQVIHLCSNDYLGLSQDKRVVQAAASALRQVSQCSSRLIAGNDPAIMKLEGILAKHRRTESALVYPTGYAANLGAVTALADKNTTIFSDELNHASIIDACRLSGARIEVFKHNDIVHLEGLVSKAAGRKIVITEGVFSMDGDSACIGDICRIAEKHDALTMVDDAHGDFIFGPKFAGIPAKFGVKVDVHVSSMSKGLGCFGGYVATSARIRELLVNTSRQFIYTSALPDHLCAAAEAAVPVAKKGGLQKRLFENIKHFSTQLKKQGFTLGNSSSQIIPVMIGDEKKTVAFSNELLKEGVFAQAVRYPTVKKGSARLRVSLTAIHEKKHIDTAIIAFEKAGRKTGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQP3</accession>
    <name>A0A075MQP3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01795</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQP3"/>
    <dbReference type="STRING" id="1459636.NTE_01795"/>
    <dbReference type="KEGG" id="nev:NTE_01795"/>
    <dbReference type="HOGENOM" id="CLU_1639892_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="161" mass="18320" checksum="6702B80286688816" modified="2014-10-29" version="1">MGIVKPRHAYYGGENNCKKCAVFLRRLYVRDIYYQDAEGKRHERVDTYGLTKKRAFAPVGWWCPSCDKTMFDGKQSKASKDNPQESTKIKCRECGSTNTVFRKERGRSKQYQCRDCSAYFSIKDNETENSAETCPECGVKVPNPDSSSELTCQGCGEQFAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQR7</accession>
    <name>A0A075MQR7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl24</name>
        <name evidence="7" type="ORF">NTE_01826</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Located at the polypeptide exit tunnel on the outside of the subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="4">One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700579.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQR7"/>
    <dbReference type="STRING" id="1459636.NTE_01826"/>
    <dbReference type="GeneID" id="41597591"/>
    <dbReference type="KEGG" id="nev:NTE_01826"/>
    <dbReference type="eggNOG" id="arCOG04094">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093240_2_0_2"/>
    <dbReference type="OrthoDB" id="10899at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01326_A">
        <property type="entry name" value="Ribosomal_uL24_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005825">
        <property type="entry name" value="Ribosomal_uL24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005756">
        <property type="entry name" value="Ribosomal_uL24_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="Ribosomal_uL24_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01080">
        <property type="entry name" value="rplX_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11143">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L26 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16906">
        <property type="entry name" value="Ribosomal_L26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01108">
        <property type="entry name" value="RIBOSOMAL_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="KOW" evidence="6">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="107"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="125"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="139"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF83886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="149" mass="16439" checksum="530986718AF51D68" modified="2014-10-29" version="1">MAIHPKLLHVPKHQRDNMVGAALSDSLRQQYKRRSARVIKGDSVKVMRGEYKGVEGKVDKVNTVEGTLEIEGIQREKVRGGQVKVPIHASKVMITGLKTDDKYRSAMLSGQKQQAEAKPKADKAAKKKAAVPKKKAAAAKKEKKEEKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQX5</accession>
    <name>A0A075MQX5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQX5"/>
    <dbReference type="STRING" id="1459636.NTE_01550"/>
    <dbReference type="KEGG" id="nev:NTE_01550"/>
    <dbReference type="HOGENOM" id="CLU_2662493_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="79" mass="9359" checksum="DFCAC2D62B36948E" modified="2014-10-29" version="1">MPAGVAENSTRHIDTLREMEAYKRQYQVRCSHHELEYSAKEKRITCVVCGKTWTFVQERGYSEVKQVFAAERDDYIPMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MR37</accession>
    <name>A0A075MR37_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Type II methyltransferase</fullName>
            <ecNumber evidence="8">2.1.1.113</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">N-4 cytosine-specific methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NTE_01958</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = an N(4)-methyl-2'-deoxycytidine in DNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16857"/>
            <dbReference type="Rhea" id="RHEA-COMP:11369"/>
            <dbReference type="Rhea" id="RHEA-COMP:13674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:85452"/>
            <dbReference type="ChEBI" id="CHEBI:137933"/>
            <dbReference type="EC" id="2.1.1.113"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.113" evidence="8"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700673.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MR37"/>
    <dbReference type="STRING" id="1459636.NTE_01958"/>
    <dbReference type="REBASE" id="90016">
        <property type="entry name" value="M.NevSR1ORF1958P"/>
    </dbReference>
    <dbReference type="GeneID" id="41597706"/>
    <dbReference type="KEGG" id="nev:NTE_01958"/>
    <dbReference type="eggNOG" id="arCOG00115">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024927_2_2_2"/>
    <dbReference type="OrthoDB" id="38200at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015667">
        <property type="term" value="F:site-specific DNA-methyltransferase (cytosine-N4-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002941">
        <property type="entry name" value="DNA_methylase_N4/N6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017985">
        <property type="entry name" value="MeTrfase_CN4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001091">
        <property type="entry name" value="RM_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13370">
        <property type="entry name" value="RNA METHYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13370:SF3">
        <property type="entry name" value="TRNA (GUANINE(10)-N2)-METHYLTRANSFERASE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01555">
        <property type="entry name" value="N6_N4_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00508">
        <property type="entry name" value="S21N4MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00093">
        <property type="entry name" value="N4_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 8 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0680">Restriction system</keyword>
    <keyword evidence="4 8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA methylase N-4/N-6" evidence="9">
        <location>
            <begin position="29"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIF84016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="292" mass="33340" checksum="F7F540B996BA9C2B" modified="2014-10-29" version="1">MLAQEEQLTNQILLGNCKDILDRLPENSVQLTITSPPYRNAINYEMHASGSGGYYRGNAGVETGDYLNEMADIFGDKVYRVTKDGGYCCVVIANEVVNGTILPLPHMLLSRLVQPFGKWQLHEEIIWHKVTGGTNRYGSFVLNPYPKYYRANVMHEFILVLRKGDVNSGRKRKEALPATHEEWTKEIANSVWHIAPVPPGYIDHPCPYPEEIPYRLMKVYSYKGDVVLDPFNGSGQTTKVAHHFGRRYIGIDMVKEYVELARSRIESEPIHIRNEALIANWKKIPSSHHYRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MR45</accession>
    <name>A0A075MR45_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700401.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MR45"/>
    <dbReference type="STRING" id="1459636.NTE_01610"/>
    <dbReference type="GeneID" id="41597388"/>
    <dbReference type="KEGG" id="nev:NTE_01610"/>
    <dbReference type="HOGENOM" id="CLU_184934_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="94" mass="10765" checksum="CCA089A62FE6E920" modified="2014-10-29" version="1">MFTDEEIRARIVLKLYRHGKWGASHTSFENLKKGFNLRDLGKDGTKRVDKIGKEMIKAGLIMSHPTGYGLEISLNPRFSQELMTLIKSHFSDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MR48</accession>
    <name>A0A075MR48_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">1,4-dihydroxy-2-naphthoate octaprenyltransferase</fullName>
            <ecNumber evidence="9">2.5.1.-</ecNumber>
            <ecNumber evidence="9">2.5.1.74</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NTE_01973</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="9"/>
    <dbReference type="EC" id="2.5.1.74" evidence="9"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MR48"/>
    <dbReference type="STRING" id="1459636.NTE_01973"/>
    <dbReference type="KEGG" id="nev:NTE_01973"/>
    <dbReference type="eggNOG" id="arCOG00480">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043611_0_1_2"/>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046428">
        <property type="term" value="F:1,4-dihydroxy-2-naphthoate polyprenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042371">
        <property type="term" value="P:vitamin K biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13962">
        <property type="entry name" value="PT_UbiA_UBIAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026046">
        <property type="entry name" value="UBIAD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13929">
        <property type="entry name" value="1,4-DIHYDROXY-2-NAPHTHOATE OCTAPRENYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13929:SF0">
        <property type="entry name" value="UBIA PRENYLTRANSFERASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005355">
        <property type="entry name" value="UBIAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="119"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF84031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="294" mass="31078" checksum="0AA88A067C7FC170" modified="2014-10-29" version="1">MVLLSSWLRAIRIRFLLASVIAVSNGLAIAYWKSGTIDPLYAGLTYAGVACLHASVDLLNDYWDHKRGIDSATTRTKFSGGTGVLPENVLTPKAVYTAGVMFLILGGAVGAYFVAVRGVTIAAILGFAVVAIYFYSTSIVNSGLGELFVAIKGAMIVLGTFFVQTGLIDPAAIFVGVIVGLLSATVLFVNSFPDFDADKSKGRRTLVILMGKQKAVQAFPIFIIAAYALIVAGIFLGFTKVYSLASFASLPFAIKAISAVRKNPASAQEFVPAMSSAVTYSRITGFVLAVSLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MR95</accession>
    <name>A0A075MR95_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein with SCP/PR1 domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01268</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700124.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MR95"/>
    <dbReference type="GeneID" id="41597073"/>
    <dbReference type="KEGG" id="nev:NTE_01268"/>
    <dbReference type="eggNOG" id="arCOG03962">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1269969_0_0_2"/>
    <dbReference type="OrthoDB" id="11873at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd05379">
        <property type="entry name" value="CAP_bacterial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31157">
        <property type="entry name" value="SCP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31157:SF1">
        <property type="entry name" value="SCP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP" evidence="1">
        <location>
            <begin position="79"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="209" mass="22826" checksum="AC580D8CBC0918C4" modified="2014-10-29" version="1">MKAIVWLSVGIVAAMLGTAFAYNTTSQGSFSALMSFAGDAKSAGSAQTEQVAKITTQTLAPSSSSKIDLAKTAKLIHQKINEQRAKFGRGALAWDPALANIALGHSKDMANRHYFSHDDLEGHRYTFRYSSAGYICKQGSGENIYRLGTTRTITEEYLASRAVNAWMDSSGHRQNILSKSFHNEGIGVAFDSVRNYYVTQDFCAVHVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRC5</accession>
    <name>A0A075MRC5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02049</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
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        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700745.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRC5"/>
    <dbReference type="STRING" id="1459636.NTE_02049"/>
    <dbReference type="GeneID" id="41597789"/>
    <dbReference type="KEGG" id="nev:NTE_02049"/>
    <dbReference type="eggNOG" id="arCOG08710">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2230258_0_0_2"/>
    <dbReference type="OrthoDB" id="374088at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="105" mass="12357" checksum="4B0CD1D04EDCB218" modified="2014-10-29" version="1">MPLDADIKSMVQAVIKSDLQAPKVPKGRVPKLKKVWKCVSAYDFLYGQRVGYYTGLAEGIMLERHRRQLTQEEQDEIFAAIEPYTKDLRKYFAYYRPAKREKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRC8</accession>
    <name>A0A075MRC8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01303</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700155.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRC8"/>
    <dbReference type="STRING" id="1459636.NTE_01303"/>
    <dbReference type="GeneID" id="41597105"/>
    <dbReference type="KEGG" id="nev:NTE_01303"/>
    <dbReference type="HOGENOM" id="CLU_2839203_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="65" mass="7688" checksum="7643ABA498665873" modified="2014-10-29" version="1">MLKIAGDAIDNQWKPKAIDTMEMQKDIPIEECRKLVEELLGSLEIKQIFYEEMWCIHLCPQFYVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRJ0</accession>
    <name>A0A075MRJ0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative low-complexity protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRJ0"/>
    <dbReference type="KEGG" id="nev:NTE_01364"/>
    <dbReference type="eggNOG" id="arCOG03124">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_286318_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.80">
        <property type="entry name" value="E3 ubiquitin-protein ligase SopA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051082">
        <property type="entry name" value="Pentapeptide-BTB/POZ_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14136">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN KCTD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14136:SF17">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN KCTD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00805">
        <property type="entry name" value="Pentapeptide"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141571">
        <property type="entry name" value="Pentapeptide repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NACHT" evidence="1">
        <location>
            <begin position="308"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="1079" mass="123637" checksum="3AC48AA3FAF789E5" modified="2014-10-29" version="1">MPYGLKEGTIEKVQFQTAWTGDSLDDLAIYTREPSMKLVLQIKNNLEFSPGDKTFIKVLKSCWSTFKKDTFDPKKEWYGIGLGIYQKNIDSHLQQLLNWARDSGDSQEFFQKVKAFDSQGKKRFVKIFEEGLKKASGLDVIDDSELFDFLKNLVVLYYDVKPEGKDRTWSINYLRQIVKDGTPQESILLFNHLVQTAAKYSASAGTLTLESLRQEIPYGIIQTDHKAVFDTVSYRKRLLEYLRFVEGFRDYTHELDKKPLKDYYLQNRAVVQDVRKWEEESSVEDGGNNWRIDKFLESGDWYLLVGAEFGIGKTSMMRMAASKLATAFLKKKEGFIPVLAFFKDKLRNVYYKENLDYVISTIVAPRQFSNKTHILLILDGLDEYGEDIEDLLLRLDSMHQSYPLMKVIITTRMNAGYPRLLEVDKFVRLLPFSKEEVDSFFDRYGVSLSYGDLSDFGLRDEEKAKPLFCWMMAVISSRTSTEIRMNKTLTANTRRALIYQEFIHSLLRGKYREEAKRSIDGFHALYVQEKKILRKIAALKQMTKGELTEVGLKQDLAKFGLVNWSQDIEPILTSYFTLRTDGLYKMVDFIHESFKEYLVAEYYIESILEGHYERLYVDMPSKETLSYLEGLVELLRNDSVRDQMGEIADMFLKSLSHGTPPNIITYSSFCNVLDSLNIMASKCFEDRDLVIGEKGAIQSELWSVTDGGSYVGKSMKDYESLWLHRWIAAYILNRLCNLPEKEELERLVKFTSHQMPNNIKEFKDAKLSRINFENANFSKSNFENAIFYGAHLTGCNFSHSNLRSTRFFGATMVGTSLDHSDCEKGNMTDANLTGANLSYANLRGAKLSNAILDSVNFGSLLVIEDGKVKAAENNGVVNLQDATLNGVKIRATVISNIELKGTNLSQCDLRSSDIVRVRLTEVNLFKSNLQNCKIVWCTFSGPNTDLSYSNLSTSIIIESNLSGCNLKNAVLLGAHLDKVDLTDADLRGADLRGTYLGRLKIGSVTVDENTKTEGVILHSADYFKRFDKDIRELIEKQNKQIRFDKRDRLKSINIIPRRTSSFTAEEMFSEVNEFKYIDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRS2</accession>
    <name>A0A075MRS2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01802</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700558.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRS2"/>
    <dbReference type="STRING" id="1459636.NTE_01802"/>
    <dbReference type="GeneID" id="41597567"/>
    <dbReference type="KEGG" id="nev:NTE_01802"/>
    <dbReference type="HOGENOM" id="CLU_1222563_0_0_2"/>
    <dbReference type="OrthoDB" id="382705at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="228" mass="24063" checksum="6844F30D1880B448" modified="2014-10-29" version="1">MKASRVIGAMAVFAIVAAVLFSQNAFALPQPITFQRSIPYTVFNSTSATVYDVTTATKAPFEISTVNTLTYTAGGANNKAILKFQSGKTGSFNALEIVQYEGKAIDINWSDKVTGTTTKIGGIAAADQETFAKELLIENTGSTLKITDITNNKVLISDFVLPSDFSLVAVSAYGETGAVTGGYNTVYLGGMNLSKAASVNTNSMMPLIMAIVMISVVVGVMAKIKNRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRT9</accession>
    <name>A0A075MRT9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase, UDP-glucuronosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_01749</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 28 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRT9"/>
    <dbReference type="STRING" id="1459636.NTE_01749"/>
    <dbReference type="KEGG" id="nev:NTE_01749"/>
    <dbReference type="eggNOG" id="arCOG01393">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060247_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21015:SF22">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21015">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--N-ACETYLMURAMYL-(PENTAPEPTIDE) PYROPHOSPHORYL-UNDECAPRENOL N-ACETYLGLUCOSAMINE TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase family 28 C-terminal" evidence="2">
        <location>
            <begin position="289"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF83810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="395" mass="44187" checksum="AF1750A67A84ED5A" modified="2014-10-29" version="1">MVDKAYLAPYGVGLGHASRMVMVADHLQQYNDVQVRFSTFGEAAKYVSMRGYQCVNAPPVEFAWSVEGGFSVKHSIANIPIWFTNLVRQVNHETRNMIMYSPDVILSDSRLSPLLAAKLLGIPSIVLLNQVKLLLSPRLREFRISRLFEAMVGEFLGSMWNLADRILVPDLPPPYTVAAHNVWCVGSAARKLEYIGFTAPKPVVTEEQVAKVASDLEIDRSRPVVFVHISGPMETRMPLIKLALEATRLADINNKEGIQFIFSEGRPHGSIEPKRIEHGWYYEWCPVRDEVFALSDLVLMRGGHTALSQAIQFGKPVVTIPIENHGEQLGNSEKIAKLGAGMMVHPKKLKPEKIAEAIEQVLSDPAYRKSVFELKKMTESLDGINNVVKIVRSYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRY8</accession>
    <name>A0A075MRY8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01804</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRY8"/>
    <dbReference type="STRING" id="1459636.NTE_01804"/>
    <dbReference type="KEGG" id="nev:NTE_01804"/>
    <dbReference type="HOGENOM" id="CLU_1202582_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="230" mass="24808" checksum="A8688F9505062390" modified="2014-10-29" version="1">MANSQYILKTNAPSSPAAWGVSVEFVVPNGVTSLASTSTGKWCTAANIFGTFDGIPYGLPPFSWVECSVTYFASGGARAQGWYFWYGWIGNTAGTYQSLSYDPTGHTIRLKLKQVFGAVTLWTATFVDLTNSTTISQPINGAQVINKLGGSWMFFENGGNTDCHNYVNAGWGPLDFNNHKFYDQNDNVITFTPTVVSDKSNPAPACCAGQTDCIGFNTSTLTISRNCTSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRZ4</accession>
    <name>A0A075MRZ4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01524</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_193354093.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRZ4"/>
    <dbReference type="GeneID" id="59387788"/>
    <dbReference type="KEGG" id="nev:NTE_01524"/>
    <dbReference type="HOGENOM" id="CLU_1880965_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="135" mass="12048" checksum="CD9CAB080E9C55B5" modified="2014-10-29" version="1">MSNSIIKNKVAFLSLLIVGVAIASYTLGTPASAFAAGDGGNGGNGGNGGNGGDSHGSGNAGDGGNGGNGGNGGDAVGAGNGGNGGDGGNGGNGGDSFGSGDAGNGGNGGNGGNGGDGGSSDDEDEDNWNYDDCGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRZ9</accession>
    <name>A0A075MRZ9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">YVTN family beta-propeller repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02232</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700891.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRZ9"/>
    <dbReference type="STRING" id="1459636.NTE_02232"/>
    <dbReference type="GeneID" id="41597952"/>
    <dbReference type="KEGG" id="nev:NTE_02232"/>
    <dbReference type="eggNOG" id="arCOG02562">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_686277_0_0_2"/>
    <dbReference type="OrthoDB" id="380260at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051200">
        <property type="entry name" value="Host-pathogen_enzymatic-act"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47197:SF3">
        <property type="entry name" value="DIHYDRO-HEME D1 DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47197">
        <property type="entry name" value="PROTEIN NIRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75011">
        <property type="entry name" value="3-carboxy-cis,cis-mucoante lactonizing enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="409" mass="43756" checksum="6C1938D84DF28936" modified="2014-10-29" version="1">MRVALATVFGILLFALLSGVRPSFGQQQDDDQNFANISAERVISLGHTFSALDIGIDLSGQILFLTDRSNRTLVLYDLENNVTKSIDVEHYTSMVAVDSATKKAYVTNGCDCPAAHDVTVIDYSKGVGSAKVEATITNVSKRASPIAINDDTGKIYVGSSSNALTVIDGTTNKVVGTIGEGRINVSGIDINPKTNQVYVIDNSTTLYKIDGATNKILGNIMIGLPSSAPKEGGNEGDSSKGRLIPTAIAVNPNTNVVYVINQKVPKPIPLGEEAPLFNTAYLVAVNGTSNTIINPNIATLNSIDFDIAVNNDTNTVYVLGLRNTGLIKVDGTTNSVSLEQDFSDLKDSFRHVVVDESTNKFYLSGRTGIFEVSENNNKANAPEFRDFVMLIPALAIAAAVITTRLLREF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MS07</accession>
    <name>A0A075MS07_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA polymerase IV</fullName>
            <shortName evidence="2">Pol IV</shortName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">dbh</name>
        <name evidence="4" type="ORF">NTE_01534</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="2">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700340.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MS07"/>
    <dbReference type="STRING" id="1459636.NTE_01534"/>
    <dbReference type="GeneID" id="41597320"/>
    <dbReference type="KEGG" id="nev:NTE_01534"/>
    <dbReference type="eggNOG" id="arCOG04291">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG04582">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_444566_0_0_2"/>
    <dbReference type="OrthoDB" id="372207at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03586">
        <property type="entry name" value="PolY_Pol_IV_kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.410">
        <property type="entry name" value="Protein of unknown function UPF0759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01113">
        <property type="entry name" value="DNApol_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050116">
        <property type="entry name" value="DNA_polymerase-Y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022880">
        <property type="entry name" value="DNApol_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002763">
        <property type="entry name" value="DUF72"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024728">
        <property type="entry name" value="PolY_HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036520">
        <property type="entry name" value="UPF0759_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002677">
        <property type="entry name" value="PRK02406.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11076:SF33">
        <property type="entry name" value="DNA POLYMERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11076">
        <property type="entry name" value="DNA REPAIR POLYMERASE UMUC / TRANSFERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01904">
        <property type="entry name" value="DUF72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11798">
        <property type="entry name" value="IMS_HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="Lesion bypass DNA polymerase (Y-family), little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117396">
        <property type="entry name" value="TM1631-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="2" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0515">Mutator protein</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UmuC" evidence="3">
        <location>
            <begin position="249"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="354"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Substrate discrimination" evidence="2">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF83597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="611" mass="67772" checksum="B68889328B7673EC" modified="2014-10-29" version="1">MRHFVGCAGWRFGNFYPQALAPKEYLSHYSRVFDVVEVGVPATYEHSFWRWARETPEGFRFVVRIPEQATTTIVEEGSALSNLLEAFRPIEEKTLAVVIRAPRGLALQDGQKWLERVLATCTYHGYSAILDFAHPSWFQDTTYNILRKHGASMYWRSGMNARAAITSDFIFLRLAGDGGNWKAELEIALKEAGQEESQVDMSIIIADSPQGANAALRHLGLPERKYAGPMPAPALPVPAPRWSAGSRMVLCVDLNAFYPSCEELREPALKGRPHAVIMTDQPAGKITRGVVSSCSYEARRFGVRSAMPLARAIALCPDMELRPVDIAYYKQVSEKVMEVLSGFADVIEQASIDEAFLDCTSKAAGDASPYEYASSVKRAIRERCGLSVSIGVAPSKSAAKIASDFKKPDGVTVVYPDRLQDFLAPLEVGRISGIGPKTQQELKKIGIATIGQLAACDVQKLTSRFGRNGLWMWQVATGADSDPVVPREDHVSISTEHSLEVYAKDRKQVLAELTALCDELYDRVAGRGYLFRTVGVKIVKSDFSVETREMSYQGPQQRRESILAAIPQLVDRFDLDAPVRKVGLRVTNLAHPGRHEAQRTLLDFVEEEEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MS18</accession>
    <name>A0A075MS18_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF155 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_01544</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700348.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MS18"/>
    <dbReference type="STRING" id="1459636.NTE_01544"/>
    <dbReference type="GeneID" id="41597328"/>
    <dbReference type="KEGG" id="nev:NTE_01544"/>
    <dbReference type="HOGENOM" id="CLU_693754_0_0_2"/>
    <dbReference type="OrthoDB" id="375321at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF83607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="389" mass="43892" checksum="DCBC8DC280D77E96" modified="2014-10-29" version="1">MIIQEGELAFLYVSDIGGEIQPKDLENRLGEYGKTCREKVPGSSWIEDGIRIVAKDAIEIFGVKSCVEIKVFSIGGILVRINVPVKNKDFAQMLEIISRAEDDVRGRAVVAVTTEGAQSSSPSSSSSSSSSAATTMADYARNLAERVREDIKPFITSPYASVDYEERYRVILVREGDRDVIEKSKKELVGLIKKEPFDKLCMEEVDEIFDNNRYAYRDNLFIADIRGAFGFVKNMDAFPVSRAAELYLLQKLQLRVYDSLLDDMLGKSYDILAKAEFKADRELGERINDIHLMRLELLEIVSAMKVARGSPRARIFSSLCETLGEVFELQDLVDSVTRKLDRLGEIYTMVYDSMQNTRFIRMDRTMLMLEAIIVVLIAIEIVLVLAGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MS71</accession>
    <name>A0A075MS71_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MS71"/>
    <dbReference type="STRING" id="1459636.NTE_02344"/>
    <dbReference type="KEGG" id="nev:NTE_02344"/>
    <dbReference type="HOGENOM" id="CLU_2730144_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="71" mass="8039" checksum="95165545D57BEB9C" modified="2014-10-29" version="1">MQVIFARSAGGLSRARFDILGHINASAYRINVSEMVVVGSNKRTITRITNNSKKMRHNRTPHMLKEGRRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MS79</accession>
    <name>A0A075MS79_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative ATPase involved in flagella biogenesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_02359</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700991.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MS79"/>
    <dbReference type="STRING" id="1459636.NTE_02359"/>
    <dbReference type="GeneID" id="41598075"/>
    <dbReference type="KEGG" id="nev:NTE_02359"/>
    <dbReference type="eggNOG" id="arCOG04148">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094838_1_0_2"/>
    <dbReference type="OrthoDB" id="63735at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014774">
        <property type="entry name" value="KaiC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004723">
        <property type="entry name" value="PRK06067.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43637:SF3">
        <property type="entry name" value="FLAGELLA-RELATED PROTEIN H-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43637">
        <property type="entry name" value="UPF0273 PROTEIN TM_0370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06745">
        <property type="entry name" value="ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01874">
        <property type="entry name" value="DNAREPAIRADA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="4" id="KW-0282">Flagellum</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KaiC-like" evidence="3">
        <location>
            <begin position="6"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF84411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="234" mass="25823" checksum="E40C720BBD86EC3B" modified="2014-10-29" version="1">MISTVSTSNEEVDRQFGGGLPLPSLVLVEGEHGTGKSALTAQFMKGMLDSKLKVLYITTESNIKDYIAKMKKITFDFSHPFLQNRLSILQVQADGITWSENLSKYLLPVVSRYMSINLKKYDVTVIDSLSVLSMHSDANTVMDFFTRCKYLVSNGMSIVMTLHPGAVSEDVALRIRSTCDGYLKIQNAIVSGRSVKVMEVVKLIGSSSQVTSQFSFEVDQNFGIKIVPISMANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MS92</accession>
    <name>A0A075MS92_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator with CheY-like receiver, AAA-type ATPase, and DNA-binding domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_01926</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MS92"/>
    <dbReference type="STRING" id="1459636.NTE_01926"/>
    <dbReference type="KEGG" id="nev:NTE_01926"/>
    <dbReference type="eggNOG" id="arCOG02391">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_15_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00156">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050595">
        <property type="entry name" value="Bact_response_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44591">
        <property type="entry name" value="STRESS RESPONSE REGULATOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44591:SF21">
        <property type="entry name" value="TWO-COMPONENT RESPONSE REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="15"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF83985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="197" mass="22230" checksum="159759B77F916781" modified="2014-10-29" version="1">MTALLTGRMFFNKMKILIAEDERDVLDAYRIALGAQGHEVVTTQNGEDCISVYRQHYEEFAKSAGDGATRTSSSSSSPHARSPFDAVLLDYRMPKKDGMEVAQEIFALYPRQRIIFASAYVRETLLDSVKQLNRVVELLQKPFRMQALIDTLEDKEIYDGLKALNVKVDQLKSTGPSHEQVSALLEGLKKLQKARTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSC6</accession>
    <name>A0A075MSC6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01957</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700672.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSC6"/>
    <dbReference type="GeneID" id="41597705"/>
    <dbReference type="KEGG" id="nev:NTE_01957"/>
    <dbReference type="HOGENOM" id="CLU_2127717_0_0_2"/>
    <dbReference type="OrthoDB" id="6090at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="113" mass="12595" checksum="712DC73E121CB2EE" modified="2014-10-29" version="1">MSKEDHISRMKALGFDGASIESFEKMWNPLADESYEMYAMYTGAEGSALEDKAGCVICSKKSFPLRWEKVITPSQDSAAIYTVCTDCDAAYVDAAIRQKALGRLLKERNTRPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSH8</accession>
    <name>A0A075MSH8_9ARCH</name>
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        <recommendedName>
            <fullName evidence="4">Late embryogenesis abundant protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700724.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSH8"/>
    <dbReference type="STRING" id="1459636.NTE_02023"/>
    <dbReference type="GeneID" id="41597766"/>
    <dbReference type="KEGG" id="nev:NTE_02023"/>
    <dbReference type="HOGENOM" id="CLU_2802407_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="67" mass="7128" checksum="F8E4834106AE0CD6" modified="2014-10-29" version="1">MGFIEDAKKEAEKKLKEGTNKAAEMANKGMDKASEMGKEATQKATEAGQKAGDAAKANLNKAKEEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSI2</accession>
    <name>A0A075MSI2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Condensin subunit ScpB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NTE_02061</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700752.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSI2"/>
    <dbReference type="STRING" id="1459636.NTE_02061"/>
    <dbReference type="GeneID" id="41597797"/>
    <dbReference type="KEGG" id="nev:NTE_02061"/>
    <dbReference type="eggNOG" id="arCOG02613">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045647_5_4_2"/>
    <dbReference type="OrthoDB" id="8628at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051304">
        <property type="term" value="P:chromosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005234">
        <property type="entry name" value="ScpB_csome_segregation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00281">
        <property type="entry name" value="SMC-Scp complex subunit ScpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34298">
        <property type="entry name" value="SEGREGATION AND CONDENSATION PROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34298:SF2">
        <property type="entry name" value="SEGREGATION AND CONDENSATION PROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04079">
        <property type="entry name" value="SMC_ScpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019345">
        <property type="entry name" value="ScpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="168"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF84118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="195" mass="22045" checksum="500F5E59838C7788" modified="2014-10-29" version="1">MRESLPEDEVAARIEAALYSAGRPLTVDELVRASGTNSKEKTMRVVNDLVKKTKTVFKAIEVVQLEDGSYVFQLKPAYTPLIRRFAQHPLVPAAALKTLTYIAYEQPVTSKRLVQIRGSQVYQHIKELEQMEFVEHESLGRLKVYRTTKKFQEYFGITDLNSMKSKLVAETNKENPRQQPPATTTTASSKADLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSJ5</accession>
    <name>A0A075MSJ5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00237</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSJ5"/>
    <dbReference type="KEGG" id="nev:NTE_00237"/>
    <dbReference type="HOGENOM" id="CLU_2730137_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="71" mass="8299" checksum="5EC722C823F351CA" modified="2014-10-29" version="1">MTDVRMRRTGTAPTMAAAEIETYETLWKNWDRIKLAELGVNTDFIRKLDDGQARDLVRGLLYLFEKHKSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSS7</accession>
    <name>A0A075MSS7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00322</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSS7"/>
    <dbReference type="KEGG" id="nev:NTE_00322"/>
    <dbReference type="HOGENOM" id="CLU_2243698_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="104" mass="11921" checksum="941714B128A99E58" modified="2014-10-29" version="1">MRFWLFLLRTREIRSAKKVQTTEQSNFRKGLPSGETVLPQSWAIRELEGSYEHTLAVALIIITWVIRGAEIELDEGYSIMTCHTQGTLLSLSPLLPILIRTCYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSX3</accession>
    <name>A0A075MSX3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cation diffusion facilitator family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NTE_02638</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701209.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSX3"/>
    <dbReference type="STRING" id="1459636.NTE_02638"/>
    <dbReference type="GeneID" id="41598331"/>
    <dbReference type="KEGG" id="nev:NTE_02638"/>
    <dbReference type="eggNOG" id="arCOG01474">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044569_0_0_2"/>
    <dbReference type="OrthoDB" id="8907at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="entry name" value="Cation efflux protein, cytoplasmic domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050291">
        <property type="entry name" value="CDF_Transporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840:SF15">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="19"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="7">
        <location>
            <begin position="16"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="8">
        <location>
            <begin position="219"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="8">
        <location>
            <begin position="308"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="8">
        <location>
            <begin position="397"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF84681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="474" mass="50663" checksum="1F15B048149BFACF" modified="2014-10-29" version="1">MAASADVSIIKRNALRYSLAAIASVFVFEFTAGIITNSLAVLTDSTHALLDAVVTAILIIAVSLAAKPRDKEHTYGHGRIETIGGFIGGAALFVVSIFFIYEAAARLAFGGTAALSVNPGMIGFAAVVYTLAVDAFRMAVLGRAMRKTRSGAATLKADLYHAIADFASTAVALVGLWLVTTGFYQGDAIAAVILGAFLAYLSSKFAYQNAFELTDSIPPRLVARVRQAAAETDGVLDCKDVKMRRVGNDIFAEVTISLKADISFEKAHEISAQVERNIESSLAQAGDSVESITVHFEPIYGPDLPLESIIERAAARVSGVKGVHNIIVSRVVDGTDRLEISLHIQVNRSASLSEAHAIASAVEESIKGQVKRAENVTVHLEPLMPEVAGVQPLADIEIQNSIRQIVLASGDIKKVGRIATFRTDEDTLKIDVDIGFSTERPSTIEQVHELVTEIEKQIRAKYPGSIVTIHAEPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSY2</accession>
    <name>A0A075MSY2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_01842</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSY2"/>
    <dbReference type="KEGG" id="nev:NTE_01842"/>
    <dbReference type="eggNOG" id="arCOG01687">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107017_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051011">
        <property type="entry name" value="Metal_resp_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43132">
        <property type="entry name" value="ARSENICAL RESISTANCE OPERON REPRESSOR ARSR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43132:SF2">
        <property type="entry name" value="ARSENICAL RESISTANCE OPERON REPRESSOR ARSR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12840">
        <property type="entry name" value="HTH_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="4">
        <location>
            <begin position="28"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF83902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="185" mass="20344" checksum="C5606306C4A28119" modified="2014-10-29" version="1">MTASCTHMADALFQKDVKVRRVTTLNHVAAQGLSDPARMRILELVSHKPMNAEEIAKALGSAGVKKATTTVRHHLDTLKEAGLVEAAKMVEVRGAVMKYYSATLRVFDCQAPADLDSKALRLIDDTSGKLAKVLKSVHEDKRFLALDKDGKCREFLALEIINAALARAMERPEYKELTAAGQQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSZ3</accession>
    <name>A0A075MSZ3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">Phosphoribosylamine--glycine ligase</fullName>
            <ecNumber evidence="2 10">6.3.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">GARS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8 10">Glycinamide ribonucleotide synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 10">Phosphoribosylglycinamide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">purD</name>
        <name evidence="13" type="ORF">NTE_02169</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>5-phospho-beta-D-ribosylamine + glycine + ATP = N(1)-(5-phospho-beta-D-ribosyl)glycinamide + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17453"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 10">Belongs to the GARS family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.13" evidence="2 10"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700836.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSZ3"/>
    <dbReference type="STRING" id="1459636.NTE_02169"/>
    <dbReference type="GeneID" id="41597893"/>
    <dbReference type="KEGG" id="nev:NTE_02169"/>
    <dbReference type="eggNOG" id="arCOG04415">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027420_3_1_2"/>
    <dbReference type="OrthoDB" id="146558at2157"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004637">
        <property type="term" value="F:phosphoribosylamine-glycine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.600.10:FF:000001">
        <property type="entry name" value="Trifunctional purine biosynthetic protein adenosine-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.600.10">
        <property type="entry name" value="Phosphoribosylglycinamide synthetase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00138">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020561">
        <property type="entry name" value="PRibGlycinamid_synth_ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000115">
        <property type="entry name" value="PRibGlycinamide_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020560">
        <property type="entry name" value="PRibGlycinamide_synth_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037123">
        <property type="entry name" value="PRibGlycinamide_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020562">
        <property type="entry name" value="PRibGlycinamide_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00877">
        <property type="entry name" value="purD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43472">
        <property type="entry name" value="PHOSPHORIBOSYLAMINE--GLYCINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43472:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLAMINE--GLYCINE LIGASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01071">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02843">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02844">
        <property type="entry name" value="GARS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01209">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01210">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 10" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="12">
        <location>
            <begin position="112"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIF84223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="431" mass="46422" checksum="C41DB81836596ABD" modified="2014-10-29" version="1">MPAAATTTVIVIGSGGREHALGWKLAQSPRVKKVYFAPGNGGTFENVDIKQNEIEKLVEFAKRQDKGDCLAVVGPEESLSLGIADAFAKEGLRLFGPKKQAAMLETSKVFAKEFMQKAGIPTAAFATFSDAQKAKDYIAGQNKPLVVKADGLAAGKGVIMCDSTQQAIEAVDKIMIAKEFGAAGGKVVIEERLVGEEASFIALCDGKTIMPLASSQDHKRVFDGDRGPNTGGMGAYSPAPVVDKALHEKIVKRVMEPVLKEMNARGTPFTGFLYAGIMVDEKTGEPYVLEFNTRMGDPECQPIMMRMKSDLYEYIDAAVDGRLGSMPPIEWHDRTAVCVIMASRGYPGAYKKGEVIEGLGDFGPDTTVFHAGTAKDAQGRIVTNGGRVLGVTATGKDARCAIENAYSAVRKIRWGENGHYYRTDIARRARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MT19</accession>
    <name>A0A075MT19_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02204</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700865.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MT19"/>
    <dbReference type="GeneID" id="41597925"/>
    <dbReference type="KEGG" id="nev:NTE_02204"/>
    <dbReference type="HOGENOM" id="CLU_2645693_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="76" mass="8567" checksum="F2AAC2C861678303" modified="2014-10-29" version="1">MVSDVTDGPSAKNVTVGFKDIPIREEFLTAEQILERAGLDPLEYELRFPNTGEQISFERVLKIKDGMKLDAVIKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MT65</accession>
    <name>A0A075MT65_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02699</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701259.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MT65"/>
    <dbReference type="GeneID" id="41598388"/>
    <dbReference type="KEGG" id="nev:NTE_02699"/>
    <dbReference type="HOGENOM" id="CLU_2032753_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="121" mass="14176" checksum="2E359B7D499A1FDA" modified="2014-10-29" version="1">MLLLESILYFSHFLVINMRDGSLDVENPKVGDKVANDEECVAMLRVAVIKCEGSDRLEPVMQFSVSKDFKFKDLLLMIDKVRERLAQIEPVKTEQDNRKREIDEYLKKIGFKLEENKRPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MT73</accession>
    <name>A0A075MT73_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Conserved flagellar protein F immunoglobulin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_02358</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700990.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MT73"/>
    <dbReference type="STRING" id="1459636.NTE_02358"/>
    <dbReference type="GeneID" id="41598074"/>
    <dbReference type="KEGG" id="nev:NTE_02358"/>
    <dbReference type="eggNOG" id="arCOG01824">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1590796_0_0_2"/>
    <dbReference type="OrthoDB" id="9682at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054458">
        <property type="entry name" value="FlaF_Ig-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22201">
        <property type="entry name" value="FlaF_Ig-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="Conserved flagellar protein F immunoglobulin-like" evidence="2">
        <location>
            <begin position="49"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF84410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="179" mass="18830" checksum="D9FDFC862313F05D" modified="2014-10-29" version="1">MGISNAVSGGIMMITMVYVMLTIPGMLDRDAAMSNTIAQRARSDDAELKTGISITSISLVPGGSAISVELANDGSTKLWEYSKFTVIAAYDANVTGNRARTTEELEYGGISATPAQAGQWVISSFDSSMDSYVDPQVVNPGEQFTIKLKPQNPIYASSPSAYITVSTQNGVTASKGGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MT88</accession>
    <name>A0A075MT88_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02373</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701003.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MT88"/>
    <dbReference type="STRING" id="1459636.NTE_02373"/>
    <dbReference type="GeneID" id="41598088"/>
    <dbReference type="KEGG" id="nev:NTE_02373"/>
    <dbReference type="HOGENOM" id="CLU_2534798_0_0_2"/>
    <dbReference type="OrthoDB" id="375753at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="86" mass="9267" checksum="15E835E9071748A8" modified="2014-10-29" version="1">MPEGEGGDDSVQISGDRLKVLLESALAMFGGPGKEYIMEDLARHGITFDSKSHYTLVQIKNALSIILGEDGAALVTDRMCRELGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MT99</accession>
    <name>A0A075MT99_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02383</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701011.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MT99"/>
    <dbReference type="STRING" id="1459636.NTE_02383"/>
    <dbReference type="GeneID" id="41598097"/>
    <dbReference type="KEGG" id="nev:NTE_02383"/>
    <dbReference type="HOGENOM" id="CLU_2392749_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="93" mass="10498" checksum="F5C7DA772FDD7FCA" modified="2014-10-29" version="1">MKTLAEVKHRGGDNNSFQFIASKLDNWDITAHVDTSGMNLKEVEKRLVSGEQVFVVVEIKDEIVEKAFVRLGGVARQQYVLAVYGIPESFRFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTE5</accession>
    <name>A0A075MTE5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_02005</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700711.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTE5"/>
    <dbReference type="STRING" id="1459636.NTE_02005"/>
    <dbReference type="GeneID" id="41597752"/>
    <dbReference type="KEGG" id="nev:NTE_02005"/>
    <dbReference type="eggNOG" id="arCOG01586">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_951887_0_0_2"/>
    <dbReference type="OrthoDB" id="6995at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043200">
        <property type="term" value="P:response to amino acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30154:SF53">
        <property type="entry name" value="HTH-TYPE TRANSCRIPTIONAL REGULATOR LRPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30154">
        <property type="entry name" value="LEUCINE-RESPONSIVE REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13412">
        <property type="entry name" value="HTH_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF84062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="294" mass="32577" checksum="0B6C21536917DC17" modified="2014-10-29" version="1">MDSKDFQLLVALEDNARQSYRSLGRRVLLSAPSVRDRLGSLKRKGVLQGFMLSIDPGVFGRDDLLLFFRGDFTRQAVLAALAAPDVSWAAWKLDERVTVGMWTKDERKAANTLADILGTRPSGRALTPRKKKEKRLAPVSIIDLSIMDALVDDPRLPFGELVKSTGLSPKTVRKHLELLLETKTISIEPLLGALTDSGKLIYQLLVAGTVGMSEVRRIMGETALTHQTQEPPMKYMLCMGGSLTEVIAKTRALEKVSGVESVTISLNREVLVSTDLRHSLIREEIKKLEKDRAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTG4</accession>
    <name>A0A075MTG4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Triosephosphate isomerase</fullName>
            <shortName evidence="5">TIM</shortName>
            <shortName evidence="5">TPI</shortName>
            <ecNumber evidence="5">5.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Triose-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">tpiA</name>
        <name evidence="6" type="ORF">NTE_02858</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="5"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701392.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTG4"/>
    <dbReference type="STRING" id="1459636.NTE_02858"/>
    <dbReference type="GeneID" id="41598540"/>
    <dbReference type="KEGG" id="nev:NTE_02858"/>
    <dbReference type="eggNOG" id="arCOG01087">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104921_0_0_2"/>
    <dbReference type="OrthoDB" id="9465at2157"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00147_A">
        <property type="entry name" value="TIM_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022891">
        <property type="entry name" value="Triosephosphate_isomerase_arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003302">
        <property type="entry name" value="PRK04302.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00419">
        <property type="entry name" value="tim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="Triosephosphate isomerase (TIM)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 5" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="3 5" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="4 5 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Electrophile" evidence="5">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="8"/>
            <end position="10"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="199"/>
            <end position="200"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF84896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="223" mass="23479" checksum="72F899D572A712F5" modified="2014-10-29" version="1">MNRPFIINFKNYGEASSAEKTLELAMAAQDVAKRLGVEVVVAPPQPALALVCKSVDIPVVSQHIDDAQQGSTTGFFVPEIAKLYGASGSLINHSEHRIGVDIIASLVKRLRSLQMTSIVCARTPDEVAAISKMEPDFIAIEPPELIGSGRAVSKENPAIITDSIKAAGGRSKVICGAGITDESDVAKAVELGSYGVLVASGIIKAKSWPDKIAELAQGMKKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTG7</accession>
    <name>A0A075MTG7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-glutamate O-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.80</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NTE_02351</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-glutamyl-[protein] + S-adenosyl-L-methionine = [protein]-L-glutamate 5-O-methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:24452"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="Rhea" id="RHEA-COMP:10311"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:82795"/>
            <dbReference type="EC" id="2.1.1.80"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.1.1.80" evidence="2"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTG7"/>
    <dbReference type="STRING" id="1459636.NTE_02351"/>
    <dbReference type="KEGG" id="nev:NTE_02351"/>
    <dbReference type="eggNOG" id="arCOG04402">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025854_1_1_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008983">
        <property type="term" value="F:protein-glutamate O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.155.10">
        <property type="entry name" value="Chemotaxis receptor methyltransferase CheR, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050903">
        <property type="entry name" value="Bact_Chemotaxis_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022642">
        <property type="entry name" value="CheR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000780">
        <property type="entry name" value="CheR_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022641">
        <property type="entry name" value="CheR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036804">
        <property type="entry name" value="CheR_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24422">
        <property type="entry name" value="CHEMOTAXIS PROTEIN METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24422:SF10">
        <property type="entry name" value="CHEMOTAXIS PROTEIN METHYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01739">
        <property type="entry name" value="CheR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03705">
        <property type="entry name" value="CheR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00996">
        <property type="entry name" value="CHERMTFRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00138">
        <property type="entry name" value="MeTrc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47757">
        <property type="entry name" value="Chemotaxis receptor methyltransferase CheR, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50123">
        <property type="entry name" value="CHER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CheR-type methyltransferase" evidence="6">
        <location>
            <begin position="30"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF84403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="281" mass="31529" checksum="0FB2B319DFA133BE" modified="2014-10-29" version="1">MIRGMTSASAAKAGADLGSSMVVERVLERGVDLRQYKENFLKRRLDIRLKARGISDYSQYALLLDSDPSEFHSLLATFSINVTEFFRDVDFYNAFYSHIIPDMHIAAGGRGEIKVWSAGCASGEEAYALAIMFSEAAESLAGFRGRIIATDFSSKSIEAARLGRYDAARLANVPEDILAKYFTHLPNGKHQVSEKLKNMIDFDIGNLATMNAPQQVDAIFCRNVLMYFDKDMQLKILTKFHKSLIDGGYFILGQSEAVMGESSALFETVMPKERIYRKKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTU3</accession>
    <name>A0A075MTU3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative signal-transduction protein containing cAMP-binding and CBS domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_02514</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701116.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTU3"/>
    <dbReference type="STRING" id="1459636.NTE_02514"/>
    <dbReference type="GeneID" id="41598218"/>
    <dbReference type="KEGG" id="nev:NTE_02514"/>
    <dbReference type="eggNOG" id="arCOG00606">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040681_12_2_2"/>
    <dbReference type="OrthoDB" id="43333at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051257">
        <property type="entry name" value="Diverse_CBS-Domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43080:SF2">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43080">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN CBSX3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="8"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="75"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF84563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="145" mass="15208" checksum="66898178C7D4F851" modified="2014-10-29" version="1">MSAVSEIMSKGVVAIDLGAGTSALDIASAMVKGKTGAVIVLRDGRPAGIITERDLLKKVVAKNVKPNQARAEDIMSSPLVTVKAYDSVDTAAGLMTKNRIKRLPVLEDDGSLAGMLSATDIAKRLAKILADDQSRYRSLNAAAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTU7</accession>
    <name>A0A075MTU7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03021</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTU7"/>
    <dbReference type="STRING" id="1459636.NTE_03021"/>
    <dbReference type="KEGG" id="nev:NTE_03021"/>
    <dbReference type="HOGENOM" id="CLU_107441_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="224" mass="24311" checksum="6D2466D04CEE6DE2" modified="2014-10-29" version="1">MPGVTPGEQNAQHLLTLCLFVAFDQNSCIHLLFRKDSTLRERATVALANLERNAYAMSVLRSRIESRADFILKSQGDGDEYKELARVLELVKNGELVLSELSGKMEAARFLEEFVMIINGAAESVNAIKSDFEHLVPLAENALAEMHDAISKISSCGLYMPDPEPAQIEVQNNILAEATAAVAQAPPLQSPSVQPQESVAAEPKAAADAPIVETRQQKAEAELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTY8</accession>
    <name>A0A075MTY8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_03097</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTY8"/>
    <dbReference type="STRING" id="1459636.NTE_03097"/>
    <dbReference type="KEGG" id="nev:NTE_03097"/>
    <dbReference type="eggNOG" id="arCOG03664">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_598027_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019187">
        <property type="term" value="F:beta-1,4-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027389">
        <property type="entry name" value="B_mannosylTrfase_Bre-3/Egh"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16779">
        <property type="entry name" value="BETA-1,4-MANNOSYLTRANSFERASE EGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16779:SF1">
        <property type="entry name" value="BETA-1,4-MANNOSYLTRANSFERASE EGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13632">
        <property type="entry name" value="Glyco_trans_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="404"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="2">
        <location>
            <begin position="137"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF85131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="452" mass="52257" checksum="81FE5F9D039CF86B" modified="2014-10-29" version="1">MFFWFSYVPIAAMSLYRVVRNRNLFVEKLAFAEKNVKRVRSDAAIIFQITTRSATKTHVVRRGIQSIIDSAKKTEYRNFHISIVTDDPDDIRTLEGVNCEVVVVNKNFKTNAIRKGRALQYAVEHRRRIGMNTSKHWIFHMDDESYVTTQTIVALLKSIESGKEVASEGPIFYPLKFEAANRLTAIAESIRPFACYDCVSQMTNPPPLHMHGSNLLIRSDIEDTIEWKFGPTLAEDQMFGYKVYEKYGPGSMGWHGGMLLEQPPLNIKDHFFQRRRWVLGTLQNLQNFPRWHRYKLMYKSVTYFLGFASAVASTAIMLYSSIPTLIPTLLNYNTIGYYDFMSLPDKLPSIFFNSIFDAVTKGSMLELSASTILLFTSIVWLGSYQLGLFLNLKYSKIEWRKRVMFHLQTLLVCPIIGLVETFPAFWAMIEYNLKKKDPAQKTKVYDFYVVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTZ5</accession>
    <name>A0A075MTZ5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Iron-sulfur cluster assembly accessory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02622</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701196.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTZ5"/>
    <dbReference type="STRING" id="1459636.NTE_02622"/>
    <dbReference type="GeneID" id="41598316"/>
    <dbReference type="KEGG" id="nev:NTE_02622"/>
    <dbReference type="eggNOG" id="arCOG04560">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069054_5_3_2"/>
    <dbReference type="OrthoDB" id="52656at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.300.12:FF:000013">
        <property type="entry name" value="Iron-sulfur assembly protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016092">
        <property type="entry name" value="ATAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000361">
        <property type="entry name" value="ATAP_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017870">
        <property type="entry name" value="FeS_cluster_insertion_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00049">
        <property type="entry name" value="iron-sulfur cluster assembly accessory protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010147">
        <property type="entry name" value="PRK13623.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43011">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43011:SF1">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01521">
        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01152">
        <property type="entry name" value="HESB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core" evidence="1">
        <location>
            <begin position="9"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="116" mass="12602" checksum="B6AB126F67B91A72" modified="2014-10-29" version="1">MESAQHVESITVTPKAAEKVAEFMKQEGNTGLYLRVYVTGGGCSGLSYGMGFEEKPDEDDSVIEQNGVKVLVDSYSQRYLRGANIDYVESLMGSGFKINNPNVTKSCSCGHSFSTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MU32</accession>
    <name>A0A075MU32_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carbamoyl phosphate synthase small chain</fullName>
            <ecNumber evidence="8">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Carbamoyl phosphate synthetase glutamine chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">carA</name>
        <name evidence="11" type="ORF">NTE_02173</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Small subunit of the glutamine-dependent carbamoyl phosphate synthetase (CPSase). CPSase catalyzes the formation of carbamoyl phosphate from the ammonia moiety of glutamine, carbonate, and phosphate donated by ATP, constituting the first step of 2 biosynthetic pathways, one leading to arginine and/or urea and the other to pyrimidine nucleotides. The small subunit (glutamine amidotransferase) binds and cleaves glutamine to supply the large subunit with the substrate ammonia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>hydrogencarbonate + L-glutamine + 2 ATP + H2O = carbamoyl phosphate + L-glutamate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate. Tetramer of heterodimers (alpha,beta)4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the CarA family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.5" evidence="8"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700840.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MU32"/>
    <dbReference type="STRING" id="1459636.NTE_02173"/>
    <dbReference type="GeneID" id="41597897"/>
    <dbReference type="KEGG" id="nev:NTE_02173"/>
    <dbReference type="eggNOG" id="arCOG00064">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035901_1_1_2"/>
    <dbReference type="OrthoDB" id="7675at2157"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00171"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01744">
        <property type="entry name" value="GATase1_CPSase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.20:FF:000002">
        <property type="entry name" value="Carbamoyl-phosphate synthase 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.20">
        <property type="entry name" value="Carbamoyl-phosphate synthase small subunit, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01209">
        <property type="entry name" value="CPSase_S_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050472">
        <property type="entry name" value="Anth_synth/Amidotransfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006274">
        <property type="entry name" value="CarbamoylP_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002474">
        <property type="entry name" value="CarbamoylP_synth_ssu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036480">
        <property type="entry name" value="CarbP_synth_ssu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035686">
        <property type="entry name" value="CPSase_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01368">
        <property type="entry name" value="CPSaseIIsmall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009475">
        <property type="entry name" value="PRK12838.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43418:SF7">
        <property type="entry name" value="CARBAMOYL-PHOSPHATE SYNTHASE SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43418">
        <property type="entry name" value="MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00988">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00099">
        <property type="entry name" value="CPSGATASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01097">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52021">
        <property type="entry name" value="Carbamoyl phosphate synthetase, small subunit N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3 8 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carbamoyl-phosphate synthase small subunit N-terminal" evidence="10">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="CPSase" evidence="8">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="373"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="377"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="342"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="344"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIF84227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="403" mass="44648" checksum="46DEF7FCB292B66F" modified="2014-10-29" version="1">MLEDGIVFSGIGFGYPSEIAGEVVFNTGMVGYTETLTDPSYRGQILCMTYPLVGNYGVPSFDVKDEYGLPKFFESDRIQVKALLIHDLSDVASHWSCVKTLDQWLYEQKIPGIYGIDTRELTKKLRVHGVMMGAIAVSDKGPVDDARMRKLVSGAKYEGLNFMPEVSTSKPQEYGDKDRPCVVLLDTGTKYSIIRNIIRTGFRVVRMPWDAPYEQIMSYDPKGVVISNGPGDPKVCTSTIKTATKLIKTSTPTLGICLGNQILALAGGADTYKLKFGHRGQNKPCVDLRNMQSYVTSQNHGYGIDPESLDGTGFKVWFANADDDTVEGIEHSSKPVIAVQFHPEASPGPYDCMFVFDRFKQIIDAGGRITDGVKAREKPKKKVTAEKKKKTTRKKEGRKVAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MU79</accession>
    <name>A0A075MU79_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HIT family hydrolase, diadenosine tetraphosphate hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_02660</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701227.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MU79"/>
    <dbReference type="STRING" id="1459636.NTE_02660"/>
    <dbReference type="GeneID" id="41598352"/>
    <dbReference type="KEGG" id="nev:NTE_02660"/>
    <dbReference type="eggNOG" id="arCOG00419">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056776_3_2_2"/>
    <dbReference type="OrthoDB" id="26806at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648:SF1">
        <property type="entry name" value="ADENOSINE 5'-MONOPHOSPHORAMIDASE HNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648">
        <property type="entry name" value="HIT FAMILY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="4">
        <location>
            <begin position="8"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="2 3">
        <location>
            <begin position="100"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="1">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF84703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="143" mass="15375" checksum="7CB1C78379345352" modified="2014-10-29" version="1">MPQDPNCIFCKIATGQIPARVIMQNDRATAFLDAFPLAAGHTLVVPKAHFQKVQDMDAPDAQAVFDLVYKITARVESAAGTGASTIAIHNGKEAGQEVSHVHIHIIPRKPGDGAGPVHSMFKNRPKLSAQEMDALLDKMNPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MU81</accession>
    <name>A0A075MU81_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MU81"/>
    <dbReference type="KEGG" id="nev:NTE_02665"/>
    <dbReference type="HOGENOM" id="CLU_2730146_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="71" mass="7799" checksum="5A139EC994F196E4" modified="2014-10-29" version="1">MEPPVIADWDGPDLASFIIKALKCARSIVSDTVRSWVPVAKNASSFLVFSVENLRWRVVVSIIISTKLAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MU85</accession>
    <name>A0A075MU85_9ARCH</name>
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        <recommendedName>
            <fullName evidence="1">DUF7482 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02677</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701240.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MU85"/>
    <dbReference type="STRING" id="1459636.NTE_02677"/>
    <dbReference type="GeneID" id="41598367"/>
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    <dbReference type="eggNOG" id="arCOG08764">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054330_0_0_2"/>
    <dbReference type="OrthoDB" id="10704at2157"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055905">
        <property type="entry name" value="DUF7482"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24298">
        <property type="entry name" value="DUF7482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7482" evidence="1">
        <location>
            <begin position="96"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="402" mass="42929" checksum="685C0BB9398883CD" modified="2014-10-29" version="1">MVLSKTKKSVVTSTVAASVLIIAILVVMSASLSSMQQQETATATSLQQQSTEDQAGTATAVAASNATVVDINAGSVLKLSRASVPIDMPLEKGYQDGKEIFFITTDASDQNFAAQLTNKSGFAVNFAPLLAKAPQDARNQAYVFTNGIKGNGTFGFQLPVVTSKPGDRNYSPLWQVNMASWKEGAAPRELTSVQQIMDAQSSGQLSVTKTGIIVNHPTIKWDGGSLKIRDDRDNITDDSPYVGGQILNIDTDRMLVTMVAHRGWGPDGKTIYYVVTDATPEMPATMMGVASVPADEKLARTPVAVDLFQFTNGINGTGPMGFQAGIGGANPDDSAKYSPMWKISFIQWKDPSQARVLENLGDINTMVADGSITLAPAMEGKHVVNCPFFGEETVSKHMHKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUB8</accession>
    <name>A0A075MUB8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02738</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701294.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUB8"/>
    <dbReference type="STRING" id="1459636.NTE_02738"/>
    <dbReference type="GeneID" id="41598428"/>
    <dbReference type="KEGG" id="nev:NTE_02738"/>
    <dbReference type="eggNOG" id="arCOG00485">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2433699_0_0_2"/>
    <dbReference type="OrthoDB" id="10580at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="90" mass="10409" checksum="E499574DA07365BF" modified="2014-10-29" version="1">MANTSFRVQAHKFSQDNIQTTLVCSKCDEVFQKEFPLDLEGQTIEFKCPVCGALGEADLPYKSAEEREELEEDFEEVEEEESGEEFEEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUP0</accession>
    <name>A0A075MUP0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02808</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701354.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUP0"/>
    <dbReference type="STRING" id="1459636.NTE_02808"/>
    <dbReference type="GeneID" id="41598495"/>
    <dbReference type="KEGG" id="nev:NTE_02808"/>
    <dbReference type="eggNOG" id="arCOG08655">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2103622_0_0_2"/>
    <dbReference type="OrthoDB" id="8516at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="107" mass="12042" checksum="FC690BCEB13140F5" modified="2014-10-29" version="1">MQYFTALKIGEKRVKVAQDLLAKYTGTAMPALALKDNKDNKWEPVGEENLYAIVKEPGGYMIALCDNKGVAKAIAQWFAEDTKNQIVEKIKSEQNMQEYFGKLSLPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUP6</accession>
    <name>A0A075MUP6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exo-alpha-sialidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03363</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUP6"/>
    <dbReference type="KEGG" id="nev:NTE_03363"/>
    <dbReference type="eggNOG" id="ENOG502N5KX">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_356262_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd15482">
        <property type="entry name" value="Sialidase_non-viral"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="Sialidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="787" mass="84887" checksum="EC8D3866EB84D14F" modified="2014-10-29" version="1">MKKFRGDSSIRCSRVTVTRFLAIFVAIMISLSTFPLSASLFNIHWQNSDAQAAGSSSPTIEPLQVSSDTITRTVTYPVLQAQGESQPSTITQTMTWYTNGTLGVADSRGYSYRISSIPTSTTTTTNTNATVPQGSSFSLLQNSTMVDQKVVTSTGLQYDVYWKAVQNENGYADRYKFTIVGTSPSPSKISLHVSTDQYIILQEDGFLTSFSTVPTSDKSELLPFISKFSNSTVIGLGIDWSDAVTSGYKMAFNSTSSSIEVPVENSSSFSIDPTTVASITSSVSPSSSDYYQGQRRLAQFDGVLFAFFYDAANQNLAYRTSTDDGATWSSTTDVSTGQMATDTNTWTIVYSTPDDIINRITLFYGVPSGSTTNVYAKRGTVSGSSITWNNATLLFSATNDVQCGAGICLSPAANTDTTNANIFAEFRWFTGSAWNYKILKSTDGGLTWSTSLNTVSPGYGTRFPSILGKLESGKMLFAFARYDASEFYYRTYDGTSWSAVSVTSGAGMANPSIKQISSDGDSLQTVYVAYLTGGNSGSLKIAKWYGNGTFQSFETADSTLSHALPSLTTTEYDVIHAYSLSGGKVYDTRNVDGSWLAPLNPFGTSFTSPDQLTSAISKAAALWEEGTSSPWDLRIGVNPEWDSSTGYQVSTDTNNQNEPTIAVRTTNASQIVVGANNINRSTDVLNCTIYQSQNGGTTWSMRTHLSKQNATDYMSDPVVTSSENGNFYFTCVEIPKGHGNNYYIRLGTSTDGGLTWTNVTTAFSTSTSGADKPWIAADAGGQFAICK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUR4</accession>
    <name>A0A075MUR4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">YtkA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701386.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUR4"/>
    <dbReference type="STRING" id="1459636.NTE_02850"/>
    <dbReference type="GeneID" id="41598532"/>
    <dbReference type="KEGG" id="nev:NTE_02850"/>
    <dbReference type="eggNOG" id="arCOG08794">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1192587_0_0_2"/>
    <dbReference type="OrthoDB" id="11724at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="235" mass="24312" checksum="1CAE7EBC8AF1804E" modified="2014-10-29" version="1">MMLMKKAALVLTLAIPILLAATLSSFSFARPAYAHTATKAGDINMEVGWGTEPPLLGQMNTITVEVTKISDGKPVANAFANAKVTVTKGGDSKDLEVLPGEAAGLYVAQIIPTQLGQMTVKITGTISGQQVNNQVNIEDVEDTKTLNFPASSGDPNQSIPQDFVNQIRTTLSDVSGQVDAAKTSAQNATDAAQKAAQDIGTIKSEADRAYLVGMAGIGVGVAGIAIAARALSRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUW3</accession>
    <name>A0A075MUW3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03423</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701861.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUW3"/>
    <dbReference type="STRING" id="1459636.NTE_03423"/>
    <dbReference type="GeneID" id="41599066"/>
    <dbReference type="KEGG" id="nev:NTE_03423"/>
    <dbReference type="HOGENOM" id="CLU_693732_0_0_2"/>
    <dbReference type="OrthoDB" id="386903at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="397" mass="43139" checksum="BAEFD734411AB972" modified="2014-10-29" version="1">MATSSKTKLFAIGLAFIFFMGTIGSLPLRQASAIESKPSLPIDPRTDIDPQIIANPPTLTAAQETKAEAIALANNEVQQAASGKSYNFDGIGFIGNTRESPVKWYPIVHINVANETGINVTIDMNTGKITNVEQYAITKLAPRVNEDGTESILSAASSPSYSSDDYKGTTNPVEMFMSTQNGVPTYTPSAASMDGQVDFLLNADEYQASGNSCLPSNVYNGYFAQVGFDYPSVGGARVVYADTLTQCVPTNIGLTYTPGHYYTFRIHAYSTPSTSWRMIAFDVNTGVTAMSPSRTGMKSYLIQAGSANTSVWMENWNPPSSTSWNARFSADLQAYSDYSDGVNYYHWPSDQQYDQQCTTFYTYPHTTPPPVMSGSLVTGGTVTWSNYNMANYIPGCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUW7</accession>
    <name>A0A075MUW7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUW7"/>
    <dbReference type="KEGG" id="nev:NTE_02412"/>
    <dbReference type="eggNOG" id="arCOG01055">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_159725_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038723">
        <property type="entry name" value="ArnR1-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14947">
        <property type="entry name" value="HTH_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ArnR1-like winged helix-turn-helix" evidence="1">
        <location>
            <begin position="2"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="84" mass="9595" checksum="847AB264CBF90BB3" modified="2014-10-29" version="1">MDIAAAILEIAQGGAIKTRIMYKAFLSFPQLKEYLELLQDGGLLDYVAEEKEYYTTEKGRQFLKMYKDVGQMIFPGARKKKIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUZ4</accession>
    <name>A0A075MUZ4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385102.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUZ4"/>
    <dbReference type="GeneID" id="43502588"/>
    <dbReference type="KEGG" id="nev:NTE_01041"/>
    <dbReference type="HOGENOM" id="CLU_113174_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="124" mass="14089" checksum="AB64D26FD4804101" modified="2014-10-29" version="1">MSSLTENNKKALIATLLVLGFAVASSAMVMPTAAFASSGYDDEDDDHHHDYNNCDDSDDDDDDNGHDHYYWSSYSHDDDDDDDDDNNCYCDNGDDDHGDYYHWSSYYNNDDDCDDDDDDNGDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MV00</accession>
    <name>A0A075MV00_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">4-oxalocrotonate tautomerase family enzyme</fullName>
            <ecNumber evidence="5">5.3.2.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_01046</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 4-oxalocrotonate tautomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.2.-" evidence="5"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699945.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MV00"/>
    <dbReference type="STRING" id="1459636.NTE_01046"/>
    <dbReference type="GeneID" id="41596869"/>
    <dbReference type="KEGG" id="nev:NTE_01046"/>
    <dbReference type="eggNOG" id="arCOG02240">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148073_5_3_2"/>
    <dbReference type="OrthoDB" id="8161at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.429.10">
        <property type="entry name" value="Macrophage Migration Inhibitory Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018191">
        <property type="entry name" value="4-OT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004370">
        <property type="entry name" value="4-OT-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014347">
        <property type="entry name" value="Tautomerase/MIF_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00013">
        <property type="entry name" value="taut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35530:SF2">
        <property type="entry name" value="BSL4019 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35530">
        <property type="entry name" value="TAUTOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01361">
        <property type="entry name" value="Tautomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55331">
        <property type="entry name" value="Tautomerase/MIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4-oxalocrotonate tautomerase-like" evidence="4">
        <location>
            <begin position="2"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; via imino nitrogen" evidence="3">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR618191-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF83119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="61" mass="6885" checksum="A1531373B2E5DC38" modified="2014-10-29" version="1">MPVIQITMSQGRTVEQKRELVKVLTRETARILNAKEDGVRVLIYEVSKENWGNAGVLGLDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVA4</accession>
    <name>A0A075MVA4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glycosyl transferase</fullName>
            <ecNumber evidence="9">2.4.1.212</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NTE_03158</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NodC/HAS family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.212" evidence="9"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVA4"/>
    <dbReference type="STRING" id="1459636.NTE_03158"/>
    <dbReference type="KEGG" id="nev:NTE_03158"/>
    <dbReference type="eggNOG" id="arCOG01389">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029695_1_0_2"/>
    <dbReference type="OrthoDB" id="43988at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050501">
        <property type="term" value="F:hyaluronan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085029">
        <property type="term" value="P:extracellular matrix assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030213">
        <property type="term" value="P:hyaluronan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06423">
        <property type="entry name" value="CESA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22913">
        <property type="entry name" value="HYALURONAN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22913:SF12">
        <property type="entry name" value="MANNURONAN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="361"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="433"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="8">
        <location>
            <begin position="83"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF85190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="458" mass="52240" checksum="2C58CF013CB07568" modified="2014-10-29" version="1">MSGQQIGKSGRIHVSKKAWAVRSVTILAVLGIIAYTVYLSLQMNDWFIFASVIFPLHSLTALVVGWIFFKSPATGKVGDDLVTVIIPVYNQNGMIESVVEAVFQSTYKNLEVVAVNDGSKDGTQEILNRLAAKYPTLKVVHKKNEGKRKAIASAFYNSKGNFLVFIDSDSIVDRNAIMELIKAFKGDPRVGAVVGHAKVWNADKNALTRCQDVWYDNSFNVRKSAESYFGSVMCCSGCLSGYRREAIANYLPYWTRAKTPIADDREMTSFVISPPKAKEMMAPATKNMMKWMARYDDAEDRSLTGQALLDWKAVYVPTALVYTEVPERMKMFVKQQKRWKRGTMRVNFFVSAFFWRRNPVMAFLIFYLEFMHTFISPLLITTAFVYEPLVLGNYWVPLLLFASMMLMGLAQGADYKFRDPSSKHWYYKPFENMLAAFVLSWLVFPAIWSLRKNDWGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVE1</accession>
    <name>A0A075MVE1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02589</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVE1"/>
    <dbReference type="STRING" id="1459636.NTE_02589"/>
    <dbReference type="KEGG" id="nev:NTE_02589"/>
    <dbReference type="HOGENOM" id="CLU_1393526_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="195" mass="21525" checksum="4FDE42D66D5C7A7B" modified="2014-10-29" version="1">MALIAPVIAATGFVFALLFYFMSTAAPEVQPPYTLQSGDAAIPCQNVVISEKDGDTYYTCPHPPNYTPDSPVAFNLPAPTYKKVLCAGHYGCSHRYGYQEIVPGNLLSEDQKRQVIDIAMNLPETRQNAGWKLDYFIVQPYDGDKWNANVQLFLAGLKQSPPSQGCGWYGSVDVDLETLKIRNISNLPPISTEKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVI2</accession>
    <name>A0A075MVI2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Molecular chaperone (Small heat shock protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_03146</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701621.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVI2"/>
    <dbReference type="STRING" id="1459636.NTE_03146"/>
    <dbReference type="GeneID" id="41598805"/>
    <dbReference type="KEGG" id="nev:NTE_03146"/>
    <dbReference type="eggNOG" id="arCOG01833">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117605_1_0_2"/>
    <dbReference type="OrthoDB" id="26084at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041800">
        <property type="entry name" value="Hsp20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="97"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF85178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="193" mass="21740" checksum="B8BA6A4CE21F7C05" modified="2014-10-29" version="1">MSSPFDEWFSKRRRAWFPDVDEMMRDMDKMMAEAFKNFEKQVPKNLVKERKLDDGSTVREMGPIVYGYSVKIGPDGKPQVRKFGNIDAFPNLLGGGLAVREEREPLVDVIKGSDDVRVVAELPGVNKDDLHLTADENSVTIESLTGEPRYRKVVDLPEPVDPKTAKSTYKNGVLEVALKLRRKSDSGVSIKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVI6</accession>
    <name>A0A075MVI6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01207</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700071.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVI6"/>
    <dbReference type="STRING" id="1459636.NTE_01207"/>
    <dbReference type="GeneID" id="41597016"/>
    <dbReference type="KEGG" id="nev:NTE_01207"/>
    <dbReference type="HOGENOM" id="CLU_1048077_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="265" mass="30930" checksum="1AD9DD03F5A270DE" modified="2014-10-29" version="1">MAEQFIEVGDILRELTRLLGKNLSRDLPDTPIQQSINTIFQLHNAHRYQERNYHIAILQFLVRNLLDIEKHDQKLLKKYRRIIRDSLDVNKYYGARFEVATASTLIRNKCNFERVIETTTPTPDFVIHEVSDVFLECGSTHLSNPRPKDFEYKIISEAKEKGRKTYCNHKTVLLLDISNILHHAIRFNMPIHARLEAITEKAVGSTKFGSLLLFDYIIDSKTHQYSHSYLRKDNSDIDSNLQLLLDRIFPSGHVRIESFYQPSFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVJ1</accession>
    <name>A0A075MVJ1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pycsar effector protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NTE_01212</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385142.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVJ1"/>
    <dbReference type="STRING" id="1459636.NTE_01212"/>
    <dbReference type="GeneID" id="41597021"/>
    <dbReference type="KEGG" id="nev:NTE_01212"/>
    <dbReference type="HOGENOM" id="CLU_1438063_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043760">
        <property type="entry name" value="PycTM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18967">
        <property type="entry name" value="PycTM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Pycsar effector protein" evidence="9">
        <location>
            <begin position="37"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIF83284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="188" mass="21464" checksum="25EA86D4FCDA64BD" modified="2014-10-29" version="1">MRNDLPNQNGDLTDSTADLFREDLKAEYEKDFEIKERIDNKASNMITMAGVIAAIFTGFGAFVLKDAALNWILGASIVAMFLELLFLIKTILSASNAYKIAEYKHVLMYSQFIQDDKFNNVEIRTWKDAERESYNSRMIKDYLDASYKNTGLNEEKIDYLKESQRAFLYAVIMIPIAAVLSVLANTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVM4</accession>
    <name>A0A075MVM4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701716.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVM4"/>
    <dbReference type="STRING" id="1459636.NTE_03256"/>
    <dbReference type="GeneID" id="41598911"/>
    <dbReference type="KEGG" id="nev:NTE_03256"/>
    <dbReference type="HOGENOM" id="CLU_2243701_0_0_2"/>
    <dbReference type="OrthoDB" id="10857at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="104" mass="11775" checksum="83D4B39787C88A0C" modified="2014-10-29" version="1">MIKVDISRLCIELKPAILGAFSADDKDIVIVHEDDIQKVKGVLEKALPADYVVAENTEDPEELAVLKKGDLEQLSLYFCSFCAMVFRSETERNLHQRVHYFGFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVW9</accession>
    <name>A0A075MVW9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lamin Tail Domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_02730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701288.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVW9"/>
    <dbReference type="STRING" id="1459636.NTE_02730"/>
    <dbReference type="GeneID" id="41598420"/>
    <dbReference type="KEGG" id="nev:NTE_02730"/>
    <dbReference type="eggNOG" id="arCOG03192">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG08231">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068383_0_0_2"/>
    <dbReference type="OrthoDB" id="148134at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1260">
        <property type="entry name" value="Lamin Tail domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001322">
        <property type="entry name" value="Lamin_tail_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036415">
        <property type="entry name" value="Lamin_tail_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00932">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74853">
        <property type="entry name" value="Lamin A/C globular tail domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50199">
        <property type="entry name" value="Staphylococcal nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51841">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LTD" evidence="2">
        <location>
            <begin position="33"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF84772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="322" mass="33943" checksum="96F9AB0DB6235666" modified="2014-10-29" version="1">MATTSKSGLFVGLLLAGLVAVSGVGSMGLVVASVYAQSPTTTTSVVINEVELNPKGNDSKGEWVELYNPTSSAVSIGNFKVKTSFKPVTISIPAGTTIGAGNFYVLAISGEKLYNSAESISLIDGSGRVADKTPSLVDRNDDSQTWQRVPDGGSEWKFKEQTKGAFNSPAIKPASSSQASDGGSSSNNGGGQQQASASSSAKCSGRCVEGIGVTIADPDTLYIQVGKERYKVDLSLTKAPARSDKNYDKAVSYTRNLCFGSSVLVDQDDSKKVNGKNLVGEVYCSSHNLNQELLDSKLVQLDKKQCSTSEFSSKDWARRNGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MW90</accession>
    <name>A0A075MW90_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator with CheY-like receiver, AAA-type ATPase, and DNA-binding domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_01491</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MW90"/>
    <dbReference type="STRING" id="1459636.NTE_01491"/>
    <dbReference type="KEGG" id="nev:NTE_01491"/>
    <dbReference type="eggNOG" id="arCOG02391">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_8_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050595">
        <property type="entry name" value="Bact_response_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44591:SF3">
        <property type="entry name" value="RESPONSE REGULATORY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44591">
        <property type="entry name" value="STRESS RESPONSE REGULATOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF83554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="120" mass="13951" checksum="970B0AF529239162" modified="2014-10-29" version="1">MVVDDEPDVVFTIKKVLESDGFEVDAFYDSDLALKRFKGGLYDLLILDVRMPVMNGFELYAKLQDIDDKIKVIFMSALSDLEEYEMAGKEEDPRRRKRHFIQKPVGNKDLIERVNTLLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWC0</accession>
    <name>A0A075MWC0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Flavin-dependent oxidoreductase, F420-dependent methylene-tetrahydromethanopterin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_02919</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701441.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWC0"/>
    <dbReference type="STRING" id="1459636.NTE_02919"/>
    <dbReference type="GeneID" id="41598597"/>
    <dbReference type="KEGG" id="nev:NTE_02919"/>
    <dbReference type="eggNOG" id="arCOG02410">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027853_3_0_2"/>
    <dbReference type="OrthoDB" id="7684at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="entry name" value="Luciferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050564">
        <property type="entry name" value="F420-G6PD/mer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43244">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43244:SF1">
        <property type="entry name" value="5,10-METHYLENETETRAHYDROMETHANOPTERIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="Bacterial luciferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Luciferase-like" evidence="2">
        <location>
            <begin position="22"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF84957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="360" mass="40533" checksum="49AF4EEF1AD7D385" modified="2014-10-29" version="1">MRIKFGFTQGLNVARLGLDETQILTAAQMADRLDYDSVWAMDHSNVPQWKNAVVNDAWLMLAAIGAVTRNVELGTCVTDAIRRHPSAIALSTITLDRITNGRGVLGIGAGEAQNVVDFGIEFSKPVTKFREQLEVIEKLFESDPDNRVNYEGQYYKLVNACLQAASVRKPRPPVYIAAGAPKTLELCATYGDGWIPIGYTPELFKAHASIIKDHAKRLGRDLSGFQFANDVDIYFSEDGEEAWNKMKNAVKVSLYKPELLKVHNIPQSSEFDFRKYFTEYTMDKPELMEAMKKAALQIPDSVARTAIGVGSPDDVIEMLERFIKAGTNHFIIRFWGDGYFKNIEMFGKKVIPYFRDQARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWD5</accession>
    <name>A0A075MWD5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03532</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWD5"/>
    <dbReference type="STRING" id="1459636.NTE_03532"/>
    <dbReference type="KEGG" id="nev:NTE_03532"/>
    <dbReference type="HOGENOM" id="CLU_502165_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="539" mass="61411" checksum="3F56E1310ECBB0A5" modified="2014-10-29" version="1">MVRTDDSSLLTGIKTDAVLYSETPGFRVTWIEWDSDFRNSGLQIQDLVVSVDGKSLDPFLKPGKMSPGIGQYGEYMYWQQMGAKPEQEIALGVLRNEGAEKLEIKGKIHSSRFYYDKQGRPALAPGGPSTIFPKDDFSDAWSGWYEKFVWKLSYLLDGAWDRQNINSRQELKEQEEHKERIDFLLKNYPGPFADAALADWTAAINLLEGKKADSIDLEYREIGAKRVELVKQEAAKAWNSFKGEISAQTIPAFPAAKIESRDQFVDKIVELPWITPRDNIINDLGKTYAVVGSQYDGYYFVLLSSPEVYRFYDAMYRYKAQVNPRLGERYQYVGRITDEPRMITFRGSPVSGLLVQALAGRAGEEEFFVDVRKTNEKGKSDFAGEAAITKFSTSTLPDDASPAQVMEEMIRAVKFADDASWKKLFADWRAITYDDGHSILDSSYAPSSYSLSSEWERSRQVIVGMVYDVRVDKVGRIRRIVKSDPKTNLPSVDEVVVFLDHYGLFDGEYRTFLNLNVHRRWTLQRLNEGPWKITSVQSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWF1</accession>
    <name>A0A075MWF1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Phosphomannomutase</fullName>
            <ecNumber evidence="12">5.4.2.2</ecNumber>
            <ecNumber evidence="12">5.4.2.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NTE_02946</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SR1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.2" evidence="12"/>
    <dbReference type="EC" id="5.4.2.8" evidence="12"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701462.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWF1"/>
    <dbReference type="STRING" id="1459636.NTE_02946"/>
    <dbReference type="GeneID" id="41598623"/>
    <dbReference type="KEGG" id="nev:NTE_02946"/>
    <dbReference type="eggNOG" id="arCOG00767">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016950_7_1_2"/>
    <dbReference type="OrthoDB" id="10363at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004614">
        <property type="term" value="F:phosphoglucomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004615">
        <property type="term" value="F:phosphomannomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43771">
        <property type="entry name" value="PHOSPHOMANNOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43771:SF1">
        <property type="entry name" value="PHOSPHOMANNOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="Phosphoglucomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="9">
        <location>
            <begin position="6"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="10">
        <location>
            <begin position="140"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="11">
        <location>
            <begin position="242"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase C-terminal" evidence="8">
        <location>
            <begin position="368"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIF84982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="440" mass="46604" checksum="DCC02B8DC5817772" modified="2014-10-29" version="1">MKVSISGARGIYGSDDLTLQQAALFAGRFASLVKSRKCIVARDTRPSGPILSQVVSASLMAAGIDVYNLGVASTPAAFREARKYGAGIIITASHNPLEWNGLKFIIEGRGLFEKELEQMMLASNPSVSQNTGREYPATASYVDDVAALVDDAGTTGAQVAVGIDAGGGASCGYSEKLFKRLGIKFQSINSIPGVSSRGPDPTADDLADLRALVTANKLALGFALDLDGDRLVVVNEKGEKLNPDATLLLCVARAAELGAKKFVTSIDTSVAVAKYVRERGGTVEHSKVGEANVVNKMLETGAEAGGEGSSAGFIMPKFNMCRDGLLAAATIATLDRKAMDDCLSFASQFVQVRSKIAADSSLHARVIEKLPDALKAECSQLITGDGVKGIIDEDSWVLVRSSNTEHAIRVSVESRAQKAQALYKKMSEKVQRIYHDQAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWF8</accession>
    <name>A0A075MWF8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Flagellar hook capping protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_01551</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700353.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWF8"/>
    <dbReference type="STRING" id="1459636.NTE_01551"/>
    <dbReference type="GeneID" id="41597333"/>
    <dbReference type="KEGG" id="nev:NTE_01551"/>
    <dbReference type="HOGENOM" id="CLU_666667_0_0_2"/>
    <dbReference type="OrthoDB" id="380275at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025965">
        <property type="entry name" value="FlgD/Vpr_Ig-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13860">
        <property type="entry name" value="FlgD_ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0282">Flagellum</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="FlgD/Vpr Ig-like" evidence="2">
        <location>
            <begin position="191"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF83614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="412" mass="43701" checksum="06DA280E95280573" modified="2014-10-29" version="1">MPGFHETFIQWIEKFLWEPGSPMTIPLPPPSSPLAAKAALAIAILLSWALLLQTAHAQQPGSGNNKKFTVALSETLAITDAASKELSMKKSITDKTTIKDATAKSVEKPTHRSIATKVTIKDSIRKNLVPAVHKLSRSISEQILVTEKARGPSVVAVKESVGIRDRALLSGAILPPTPPQLTILEAGQKTFRSDRDDSVAIEFHSSSAGTYKVDIENAAGGTVATLAGAMAAGENQIKWTGTDSQGKAAPSGTYTYYITARNDQGTRNAPSGGDGKIVVAGDEVAGSSVFPGRQDLEKIPFMESLPIVVLPIAAAAAGAAAFLISKRKKRLVLYLPPDAAPVIDDIKQKYPQATVEDYMGPGEQGSSRYMGVVISNSIESDDEWISGIIAKAKELAGVDSINLSYRGKIKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWQ8</accession>
    <name>A0A075MWQ8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Plastocyanin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385703.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWQ8"/>
    <dbReference type="STRING" id="1459636.NTE_03520"/>
    <dbReference type="GeneID" id="41599141"/>
    <dbReference type="KEGG" id="nev:NTE_03520"/>
    <dbReference type="eggNOG" id="arCOG02926">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_989026_0_0_2"/>
    <dbReference type="OrthoDB" id="11088at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052721">
        <property type="entry name" value="ET_Amicyanin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36507">
        <property type="entry name" value="BLL1555 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36507:SF1">
        <property type="entry name" value="BLL1555 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="281" mass="31129" checksum="ACD96AAF88BEBB1C" modified="2014-10-29" version="1">MINFKTSAPLWACMVAAVLLAAVLLPSAAILTPNSAYAFHTFGGTYVVTIVPGAAQKESLYHYYPPKIAVPRHTEVAWFENDPEQPHTVTSGSPGSPDSGQLFNSGVMSYLYFFQYEFDKAGDYSYYCQIHPWRTGLVHVSDQSTLGKNFEFSTGTGSTWSLSEFDRNLLKFEPTTVSLEETTPASYYFTMANSDTKQTVYSHYFPSTNNLQVELISGSNYNQTTTYGPDRASTIHSNPGAFHVQGNFAPGNYTISVVLYSVNGKLSDPLPLDQFKFQLTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWW4</accession>
    <name>A0A075MWW4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Small ribosomal subunit protein eS19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rps19e</name>
        <name evidence="6" type="ORF">NTE_03108</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">May be involved in maturation of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the eukaryotic ribosomal protein eS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_075055412.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWW4"/>
    <dbReference type="STRING" id="1459636.NTE_03108"/>
    <dbReference type="GeneID" id="41598768"/>
    <dbReference type="KEGG" id="nev:NTE_03108"/>
    <dbReference type="eggNOG" id="arCOG01344">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108559_1_0_2"/>
    <dbReference type="OrthoDB" id="371836at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000449">
        <property type="entry name" value="30S ribosomal protein S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01474">
        <property type="entry name" value="Ribosomal_eS19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001266">
        <property type="entry name" value="Ribosomal_eS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027548">
        <property type="entry name" value="Ribosomal_eS19_archaeal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006811">
        <property type="entry name" value="PRK09333.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11710">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11710:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01090">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01413">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF85142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="151" mass="16781" checksum="7613588631C5CC4B" modified="2014-10-29" version="1">MAKVYDVPADELIAKLAEQLKKDKKIEPPAWSAFVKTGSHAEKIPQNRDWWYTRCASLLRKIYLHGPIGVSDLKVAYGGRKQIGYNLSHHKDAGGAIIRHAIQQLEAAGYVTKLPAKGRVVTSEGTKKLDRLATEIHKELVKAAPALQRYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWZ5</accession>
    <name>A0A075MWZ5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Ribosome biogenesis protein Nop10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nop10</name>
        <name evidence="8" type="ORF">NTE_01738</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NOP10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700502.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWZ5"/>
    <dbReference type="STRING" id="1459636.NTE_01738"/>
    <dbReference type="GeneID" id="41597508"/>
    <dbReference type="KEGG" id="nev:NTE_01738"/>
    <dbReference type="eggNOG" id="arCOG00906">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_196480_1_0_2"/>
    <dbReference type="OrthoDB" id="7259at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.40">
        <property type="entry name" value="H/ACA ribonucleoprotein complex, subunit Nop10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00803">
        <property type="entry name" value="Nop10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007264">
        <property type="entry name" value="H/ACA_rnp_Nop10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036756">
        <property type="entry name" value="H/ACA_rnp_Nop10_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023532">
        <property type="entry name" value="Nop10_arc-typ"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009623">
        <property type="entry name" value="PRK13130.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13305:SF0">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13305">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NOP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04135">
        <property type="entry name" value="Nop10p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144210">
        <property type="entry name" value="Nop10-like SnoRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 7" id="KW-0698">rRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF83799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="60" mass="7014" checksum="7ED1363FB4B9B5E2" modified="2014-10-29" version="1">MRHLIRKCTACGAYTLANTCPKCNSQTADPHPPKYSPDDKYVRYRVAERYEEEEGDKDYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MXJ4</accession>
    <name>A0A075MXJ4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NTE_01966</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226986930.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MXJ4"/>
    <dbReference type="STRING" id="1459636.NTE_01966"/>
    <dbReference type="GeneID" id="41597714"/>
    <dbReference type="KEGG" id="nev:NTE_01966"/>
    <dbReference type="eggNOG" id="arCOG06128">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_309646_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005372">
        <property type="entry name" value="UPF0182"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39344">
        <property type="entry name" value="UPF0182 PROTEIN SLL1060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39344:SF1">
        <property type="entry name" value="UPF0182 PROTEIN SLL1060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03699">
        <property type="entry name" value="UPF0182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="860"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="868"/>
            <end position="881"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF84024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="984" mass="108275" checksum="8387E9DAC57F23AE" modified="2014-10-29" version="1">MWDTYSSGEDKAPRADVGRLVKWGILAAMGIVIFAVASNQAVNLLLNLTEFGNAYSKTLYYSITSGLALAAIALVRVNVASRHSIVWYSISLIARFVKRNSDFEAPSRPARYSDFHMSPLSFGLWQATKVVILAPLFANIGFGMAIAYMAEGNDIGISSVGSIFSIPFATVPADNGAFAQENVIPAIPVLALLVPPLIGAIGIRLLVYVGVSGAVNIVSQYMVDSAEHKPKFLSYISTVEVIVGAAIFWAGFTLFFSAGIDFNTKYLIAGALALGAALIFYGFMDKRRARVIIYPPRRHVYLRLLTVAAVVAIVGSIVAVNTSIAEAKKVEWRGPYISQEIAVNRNMAELDKVSVVNYDVKPPSVAPANIPQMVNANRDTLNNIRLWDQEAATQKLKPELGQRNDIVFADTDMLRFSGTMYWTGTTTPKLPDTVAQGTEWFNRHLVYTHAIPGFKMLEADTGNIVSESKFFPQERIYYGESGDEGLFSRSWSAYPVGRTTSDEISQFFYNGTGGIDVSPPISWMFEPNFMLSYPDTPIHIMRYKDIHDRMDLLYPYFVYDFAFSNDDTVAPIFHKVGVLPVTDGKNTYWLMPLVAALDTSHVPWGSPFMLKLVGYSLIDTYNGDVKIIVTGNDKFSDIFYDQYKGLGATRDVPHWLDQQIRYPEEMFIWKIAKFNRYHVTDPKAFIEARQFYDIPKDGSKDIPPYYIMTKPQGFDSPQFVGFQSLELSGSSTKNLVGYMIVENDLSTLGKMTFYSVPLDSATKLIGPSAAKEALEKDKEYKNVKTLLQGNPRVGENILYRIGDQEVYFIPVYTANTSGGVVSQIGTIAAVGASVTGTFNVGLGDNPVQAFENYLLKAAGQQPTDVTPGGQGTTTGGGGGGAPAPTTLDVQDRIDAIERVFSDAGVQVIKPTAISSPLEFKEAGATYKADTDFKLVQEAIAKFMQDNPPDNGRVYEWQDENKVNFGVLKVSGGIVENHYISIEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MXL7</accession>
    <name>A0A075MXL7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01986</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MXL7"/>
    <dbReference type="STRING" id="1459636.NTE_01986"/>
    <dbReference type="KEGG" id="nev:NTE_01986"/>
    <dbReference type="HOGENOM" id="CLU_206259_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="65" mass="7472" checksum="2FAFB357E0CA2D6E" modified="2014-10-29" version="1">MARNFIRMFCVNNVNMAQVPTTNSTARQRVQKSRNNLLFGVHLFMLGSFVSLVGYLGMMCHHMLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MXV1</accession>
    <name>A0A075MXV1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Condensin subunit ScpA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700753.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MXV1"/>
    <dbReference type="STRING" id="1459636.NTE_02062"/>
    <dbReference type="GeneID" id="41597798"/>
    <dbReference type="KEGG" id="nev:NTE_02062"/>
    <dbReference type="eggNOG" id="arCOG02610">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1227618_0_0_2"/>
    <dbReference type="OrthoDB" id="9051at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.580">
        <property type="entry name" value="Structural maintenance of chromosome 1. Chain E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003768">
        <property type="entry name" value="ScpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023093">
        <property type="entry name" value="ScpA-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33969">
        <property type="entry name" value="SEGREGATION AND CONDENSATION PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33969:SF2">
        <property type="entry name" value="SEGREGATION AND CONDENSATION PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="233"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="243" mass="27580" checksum="297839F6E2243E94" modified="2014-10-29" version="1">MSEAGEAPSEVPDTKKTIAQPPLNILFNPSAVIRKDVWNVDIVRLLELFLQLINATGNKDLRICGIAAVSSSMIYRLKVESIFLLEKIAMQKKGVDDPQQQLPIPQLNTLDLPFRVESTYPVSVEDLLKVLENMIMELANPRPRKKQVELEPVQTFNFDQYLVKFEQIIQGYEDMIFDIVSADGPTMFKTLVAKMEPVETARCFIAMLYLAMKGKVDLEQPDDSDDVRITLRQPEPAQAQQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MXX8</accession>
    <name>A0A075MXX8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative flavoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_03459</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SsuE family. Isf subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MXX8"/>
    <dbReference type="STRING" id="1459636.NTE_03459"/>
    <dbReference type="KEGG" id="nev:NTE_03459"/>
    <dbReference type="eggNOG" id="arCOG04624">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055322_2_2_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADPH-dependent FMN reductase-like" evidence="2">
        <location>
            <begin position="2"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF85487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="102" mass="11328" checksum="C39C782608327A75" modified="2014-10-29" version="1">MFVTLEYNHRIPGALKNAIDFLFKGWNNKAAGFVGYGSADSVRSTEQLGLMTAELMGATVRAQAQLSLFTDFENFSVFKPAPYQEKSVNTICWTKLFLGPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MYN1</accession>
    <name>A0A075MYN1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MYN1"/>
    <dbReference type="STRING" id="1459636.NTE_02316"/>
    <dbReference type="KEGG" id="nev:NTE_02316"/>
    <dbReference type="eggNOG" id="arCOG08723">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1727301_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="128" mass="14010" checksum="BF3C97143607A64A" modified="2014-10-29" version="1">MRDFEVFPEREEGPGAIYIEAADKVTLKKIREMTFVNAKEILGIIYSSKSGNTQLKWRQTRRRTGKVQGNASPNALVNLVEAGVLTQEWVDQYIHAQAPSGDKTTTAAATAATTTEEEGQENTTAPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MZC9</accession>
    <name>A0A075MZC9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NADH:ubiquinone oxidoreductase 27 kD subunit</fullName>
            <ecNumber evidence="4">1.6.5.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_02557</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 30 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.3" evidence="4"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701145.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MZC9"/>
    <dbReference type="STRING" id="1459636.NTE_02557"/>
    <dbReference type="GeneID" id="41598252"/>
    <dbReference type="KEGG" id="nev:NTE_02557"/>
    <dbReference type="eggNOG" id="arCOG01551">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042628_6_1_2"/>
    <dbReference type="OrthoDB" id="43567at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.80">
        <property type="entry name" value="NADH:ubiquinone oxidoreductase, 30kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037232">
        <property type="entry name" value="NADH_quin_OxRdtase_su_C/D-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001268">
        <property type="entry name" value="NADH_UbQ_OxRdtase_30kDa_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10884:SF14">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10884">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE IRON-SULFUR PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00329">
        <property type="entry name" value="Complex1_30kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143243">
        <property type="entry name" value="Nqo5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase 30kDa subunit" evidence="3">
        <location>
            <begin position="102"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF84604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="226" mass="24759" checksum="C857907F40EBF566" modified="2014-10-29" version="1">MSSDKEEQKKPAPPAKPAPAAAKPEDSNATTKPVPKPAAAPPSPAAAKPAPAAAKPAAAAAPPAAKKEPEPPAFEKGIAQQLVTRFGNAVKVLYIRPLRIKVQVEPGNLIEVASYIRDNMGFDHAECASGTDYPKDSQIEVNYHLGSYTRDDLLAHVLVLATRTNRDDAHIPSLINVFKSVEYHERETFEMLGVYFDGHPRNERFLLPEDWADIPPLRKEFRIKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MZW3</accession>
    <name>A0A075MZW3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Replication factor C small subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Clamp loader small subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NTE_02737</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the activator 1 small subunits family. RfcS subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226986999.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MZW3"/>
    <dbReference type="STRING" id="1459636.NTE_02737"/>
    <dbReference type="GeneID" id="41598427"/>
    <dbReference type="KEGG" id="nev:NTE_02737"/>
    <dbReference type="eggNOG" id="arCOG00469">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042324_2_1_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000952">
        <property type="entry name" value="Replication factor C subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001679">
        <property type="entry name" value="PRK00440.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF20">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="45"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF84779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="336" mass="37317" checksum="A125D2A065558A9E" modified="2014-10-29" version="1">MSVTTKKSDLANLMWTEKYRPQKLDEVVDQKDIIKGISNLIKGRDLPHMLFSGPAGVGKTTAALCIVKELFGESWRDNVLQLNASDERGIKMVREKVKEFTRWGSPTGEQETKELFKIIILDEADEMTSEAQTALRRMMEDGARTTRFIIICNYLSQIIEPIQSRCVVFRFTRLPREAVLEHMEEIAKKEGAKYDEKALVHIYDATGGDMRHSINIMQAAAGMGAINSANVTSAIGLSGRSKVGDVVKLALAGKFNEARAKLLELTQVYGMSEGDFMKYASQEAYEMKLENPGEFAEIMAEYDYRLASGAHPEIQMAALLAQLGKLGGSSSSSKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N0I0</accession>
    <name>A0A075N0I0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">C2H2-type zinc finger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02954</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
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    <dbReference type="GeneID" id="41598627"/>
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    <dbReference type="HOGENOM" id="CLU_1514666_0_0_2"/>
    <dbReference type="OrthoDB" id="373996at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="128"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="184" mass="21247" checksum="7777BD4F72B7433C" modified="2014-10-29" version="1">MPTAFDDDGLGLILKGYDLAPNAALETMIAIYTLDVAQTILDEHPEIVDKWLEKIHNEHLERIRSCEFEQDPVACFNVSSYDEFERHFQSWQDGGMIAIHLPKNRTVYLSKKPLFSVQVAEKPSIERHVCEKCLAVFGSIDELEKHYEKEHDAATPSPTERGKVYTIKTESDVDEYYSQNPIWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N279</accession>
    <name>A0A075N279_9ARCH</name>
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        <submittedName>
            <fullName evidence="2">Universal stress family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701928.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N279"/>
    <dbReference type="GeneID" id="75933645"/>
    <dbReference type="KEGG" id="nev:NTE_03521"/>
    <dbReference type="HOGENOM" id="CLU_2299214_0_0_2"/>
    <dbReference type="OrthoDB" id="105697at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00293">
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    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UspA" evidence="1">
        <location>
            <begin position="13"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="100" mass="10837" checksum="7BD852C2B70AFA4B" modified="2014-10-29" version="1">MEGEEVEENAAPFSRILVAVDNSKRAIRAFDYAIRLSMLAPYRAATISVVYAVTPPVAGEEGVPAPKLIESLRKEGEQLIAQLKLLAQTQLAVRAGVTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLI2</accession>
    <name>A0A075MLI2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphate transport system permease protein PstA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NTE_00044</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987078.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLI2"/>
    <dbReference type="STRING" id="1459636.NTE_00044"/>
    <dbReference type="GeneID" id="41595996"/>
    <dbReference type="KEGG" id="nev:NTE_00044"/>
    <dbReference type="eggNOG" id="arCOG00168">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033621_2_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="entry name" value="MetI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005672">
        <property type="entry name" value="Phosphate_PstA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051408">
        <property type="entry name" value="Phosphate_transprt_permease"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00974">
        <property type="entry name" value="3a0107s02c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42922">
        <property type="entry name" value="PHOSPHATE TRANSPORT SYSTEM PERMEASE PROTEIN PSTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42922:SF1">
        <property type="entry name" value="PHOSPHATE TRANSPORT SYSTEM PERMEASE PROTEIN PSTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="MetI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="196"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="266"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="82"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIF82128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="302" mass="32032" checksum="4288F44A21909CB7" modified="2014-10-29" version="1">MQPRQERKKMIQDAMVRTNARRRLADKLFTAVTVACIAAAMIPLGSILVEVVKNGAGAITAEFLTQPQGSIIAGDGGIGPAIQGTLLVVALASLIGIPVGVLAGIYLSEYARDSRFARAVRFLNNVMTGLPSIVIGIVGYVVLVLTIGSFNITAGAVALSIIMIPIIVGVTEETLKLVPNSVREAGHSLGIPKWKVTIFITLMAAKSGVLTGIVLAIARIAGETAPLIMTILGTSLFFQGFSGPVDALPLRIWRLASLPYEHAHSFGWGAALVLILIVLSLSIVLRFVVLRRKRGRVNVVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLI8</accession>
    <name>A0A075MLI8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Roadblock/LAMTOR2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00244</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLI8"/>
    <dbReference type="KEGG" id="nev:NTE_00244"/>
    <dbReference type="HOGENOM" id="CLU_2091190_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="116" mass="13131" checksum="B612F52C61EC0C9D" modified="2014-10-29" version="1">MDELSLESIVKSDEDVLIAALLEADEPVDWYVREGTPVPNEQTWKQLAFRAQIVTSMTESARDYLGDLEYVSASYKFGQVFLFPTGVQKVLCLVTKSGKQKIGLIENIQQRITKME</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLL1</accession>
    <name>A0A075MLL1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00279</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699360.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLL1"/>
    <dbReference type="GeneID" id="41596187"/>
    <dbReference type="KEGG" id="nev:NTE_00279"/>
    <dbReference type="HOGENOM" id="CLU_136580_0_0_2"/>
    <dbReference type="OrthoDB" id="11034at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="141" mass="15659" checksum="4DEB8F2EF92CDCB8" modified="2014-10-29" version="1">MKIGKAISIELDDGQRLSLSLKEAGELYLKLGKMLTYDREAGKNKSGRKSRTTFARSSNTTVTLSDAKRQEILAHLNKQISDTPRTLTNLLKGAKYSPSQLPLIRNMVESQQSIKAKAKGKRILYLRKRIKAIATKAAKGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLN8</accession>
    <name>A0A075MLN8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00319</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLN8"/>
    <dbReference type="KEGG" id="nev:NTE_00319"/>
    <dbReference type="HOGENOM" id="CLU_2203998_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="107" mass="11478" checksum="117EB80226912FCC" modified="2014-10-29" version="1">MLGTPNAGSPLADSANICMPATLDIRSGANATKAQMNPNVKYYIIAGDWLHDFGGSPLIPGPDDGLVAVSSVESEKYFQSLGRTSHSHAELLGEQEYNMTRNVLVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLS4</accession>
    <name>A0A075MLS4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF8156 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLS4"/>
    <dbReference type="STRING" id="1459636.NTE_00006"/>
    <dbReference type="KEGG" id="nev:NTE_00006"/>
    <dbReference type="eggNOG" id="arCOG07300">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_189635_0_0_2"/>
    <dbReference type="OrthoDB" id="381826at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058469">
        <property type="entry name" value="DUF8156"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26485">
        <property type="entry name" value="DUF8156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8156" evidence="1">
        <location>
            <begin position="8"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF26485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="85" mass="9879" checksum="F65D734A3DDF526C" modified="2014-10-29" version="1">MSLFPDKDILAREIESWKGFADSLRAEDRKLFTTMLDNCHIYAAAINAKGEPFPTEALLMALIFQQQRMINWFIEQVKARKKKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLU4</accession>
    <name>A0A075MLU4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Kef-type K+ transport system, membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NTE_00389</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLU4"/>
    <dbReference type="STRING" id="1459636.NTE_00389"/>
    <dbReference type="KEGG" id="nev:NTE_00389"/>
    <dbReference type="eggNOG" id="arCOG01955">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005126_1_2_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42751">
        <property type="entry name" value="SODIUM/HYDROGEN EXCHANGER FAMILY/TRKA DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42751:SF3">
        <property type="entry name" value="SODIUM_GLUTAMATE SYMPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="244"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="297"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="9">
        <location>
            <begin position="39"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="412"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="413"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIF82471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="437" mass="46314" checksum="0F61FA5BF6D9F7A4" modified="2014-10-29" version="1">MQTMIPKFFAYIFNQCYLLLTQMVAEAAQVIQDFAIVMVIASVMALVFYKIKQPMVIGYIAAGMVIGPYTPPFSLISHPEVVNLLAEIGIVLLLFVVGLEYPIAKLRSVGKKALVIAMTEAFGTLALGYVVGQAMGLALFDSLFLALSISVTSTVIVMRVLEELGMLQDKASVLLLGVAVIEDIIIVSILAVLQSVASTGSLSILEIGVSIGLVLAFIGGALFIGSKTVPKFVDLIGRTNHHDLVIVAVLGVAFGLSFIANEIGISVAAGAFFAGVLVAESKSHAVARVLSMPLRDMFAALFFVSVGALMDISLLPLFIAPALILIATSFGSKFATVYFSAKLLRTDKKTSMKAGFALSASGGELALVTAKGGADVGATSAFILPMVGTMTIITTFLSPYVIKFGWKLANSLRGEKKEEEEKEKEEKREEGGDLPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLV5</accession>
    <name>A0A075MLV5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NTP pyrophosphohydrolase</fullName>
            <ecNumber evidence="4">3.6.1.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_00036</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="3.6.1.13" evidence="4"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699186.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLV5"/>
    <dbReference type="STRING" id="1459636.NTE_00036"/>
    <dbReference type="GeneID" id="41595988"/>
    <dbReference type="KEGG" id="nev:NTE_00036"/>
    <dbReference type="eggNOG" id="arCOG01073">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062658_5_2_2"/>
    <dbReference type="OrthoDB" id="104705at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047631">
        <property type="term" value="F:ADP-ribose diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006753">
        <property type="term" value="P:nucleoside phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019693">
        <property type="term" value="P:ribose phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839:SF18">
        <property type="entry name" value="NUDIX HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839">
        <property type="entry name" value="UDP/ADP-SUGAR PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="43"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF82120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="190" mass="21495" checksum="DF4F2CC460A7F12D" modified="2014-10-29" version="1">MKNAPEGWKILSSKKVYGHRYLSVYEDEMDLAGKRKKTYIRGRRLDYSTIVPFSDDAKSILTIKSYRHLVDSYQVEVPSGYIEKGESPLQAARRELEEETGYVAKKMVLVGSYTLDYSMFEQTGNVFAAYGLEDTGTKRLGSMEKISQVSFVPVQRVKKMLLEGRILNAASIVALYRAIHYNEAGSGEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLW1</accession>
    <name>A0A075MLW1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00409</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLW1"/>
    <dbReference type="STRING" id="1459636.NTE_00409"/>
    <dbReference type="KEGG" id="nev:NTE_00409"/>
    <dbReference type="HOGENOM" id="CLU_033520_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="432" mass="47161" checksum="4B74F15E01CC0528" modified="2014-10-29" version="1">MLALSLFLTGGAIGNDDVVSAIEGNGKKAAPSITIDPLPANNNNSSGEPIASNSTTTAIIINGKASGFGNSTIKMVEVRIENATYEPATPASPGDWSTWTYHYYYYPYLLQPGIHEIVARATDSDGSRQWYVMPITVSQAQDPSQSVQAASPLPVPAAATTDRFGITKLYPTAAGGLEWSSSWDNDNPRQIGNEIDPDDSWFDTDHGEGTYTVDGNGTLTAAGNFTRMYVHDPANVREWSENLEITVYVNRINETQLVDYSGPEIFARTNHGTNADENVNLCDDRGYGGVVLDSGKWAFVKEIAHHLPNGYTEVGTVNPWSELPKNTWVGIKFVLRNMDNDTKVKLELYRDMTGGLNGGRWEKMTEFIDNGTNFGVGMEPCKSLVNPALPLVHSLVDASSESKKPMLSVYIRSEFATVGFSNFSIREINPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLW4</accession>
    <name>A0A075MLW4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Luciferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLW4"/>
    <dbReference type="KEGG" id="nev:NTE_00146"/>
    <dbReference type="eggNOG" id="arCOG11894">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_159352_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040841">
        <property type="entry name" value="Luciferase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17648">
        <property type="entry name" value="Luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Luciferase" evidence="1">
        <location>
            <begin position="37"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="106" mass="12316" checksum="8B803FA0D34BF150" modified="2014-10-29" version="1">MDLPSSEVIKRELLGWEGVTIHEHDFATTRFYVNGIEMGHIHGDEIADLQFPTRISKRLISEGKVLPHHVIPKSGWVSHEIQKPEDVKAVIDLFYLQHQRLIRKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLY9</accession>
    <name>A0A075MLY9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein (ATP-grasp superfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00066</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLY9"/>
    <dbReference type="STRING" id="1459636.NTE_00066"/>
    <dbReference type="KEGG" id="nev:NTE_00066"/>
    <dbReference type="eggNOG" id="arCOG00348">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075000_1_1_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10900">
        <property type="entry name" value="PAC-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019151">
        <property type="entry name" value="Proteasome_assmbl_chaperone_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038389">
        <property type="entry name" value="PSMG2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35610:SF7">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35610">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09754">
        <property type="entry name" value="PAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159659">
        <property type="entry name" value="Cgl1923-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="253" mass="27536" checksum="5281C992404942FD" modified="2014-10-29" version="1">MWQWALKCVIGLKVHRTPQFSGQPRIVAALPDMGNVAGIGLAYLAKKLDAKVFAELYSFWPPFVSYKDGGIVDYKQASYRFYAVDASDLLIFTGDFNPADPRRLYEVCDEVLGMAQRMNAGALYSIGAALRQPGAGGKVLAAVNNPALVQPLKQAGAEMLQGEGQISGFNGLVLGFAKERGIDAACVLGEIDNPNIIQPKAAQSILQVLLRLLGLESFDMAQLDEEEKRKNFMEQQVGYLEKVIERGEPPGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MM48</accession>
    <name>A0A075MM48_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MM48"/>
    <dbReference type="STRING" id="1459636.NTE_00480"/>
    <dbReference type="KEGG" id="nev:NTE_00480"/>
    <dbReference type="HOGENOM" id="CLU_1154314_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="240" mass="28005" checksum="DE11DB3F886BFDCB" modified="2014-10-29" version="1">MIGLILDFAKEKKFLFLLHKEKRYGWNLKAFEKWWYSDDGDGDDDDRVSQYCGHPVPLRDFMLFVKANALKVFEKKVSALSLKQVRAYDKTTTAADIKEWLLIAFKHDGSKTGNQKPSLNVPQNYFARFENLAWHYDGKESQTQNLRTFEKWWCYTAAIKVTSTGEIARGPADASFCRSDYSNINNNKNHDLEVLMRFYEKNREKIIWDFAYQHSSPIGHIEHPTDAHLLRGAFYGAFRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MM95</accession>
    <name>A0A075MM95_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thermosome subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NTE_00525</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699545.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MM95"/>
    <dbReference type="STRING" id="1459636.NTE_00525"/>
    <dbReference type="GeneID" id="41596398"/>
    <dbReference type="KEGG" id="nev:NTE_00525"/>
    <dbReference type="eggNOG" id="arCOG01257">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008891_7_3_2"/>
    <dbReference type="OrthoDB" id="9362at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03343">
        <property type="entry name" value="cpn60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012714">
        <property type="entry name" value="Thermosome_arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02339">
        <property type="entry name" value="thermosome_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF82606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="558" mass="60424" checksum="A7BC097C19D98133" modified="2014-10-29" version="1">MSSSLSLVGNTRDGVPVVLLKEGTSDTRGRDALRNNIEAAKIIASMLRSVLGPRGMDKMLVDSTGNVTITNDGATILKEMDVQHPAAKMMVEIAKAVDNEVGDGTTSSVIIAGALLEKAEELIKQGIHPTVIVDGYRKAMRRSIDILNEIAEDVNVDDHDEVLREVARTSMESKIVSVDSNVLSDLAVKAILAVAEKPGHIGIQKEDDDNNNNYFMPVDLDNVKVQRKPGGAMSDSSLIEGIIVDKEIAHPDMPRVIKDAKILLLNSPLEIEKTEFEAKISIDRPEQMKMFLEEETAMMKTMVEKIANTGANIVICQKGIDDVALGYLAKANISALKRVKESDINALAKATGARAVTNLDDPSTNDLGFAQLVEERKIETDKWVFVEKCKNPKAVSILIRGGSERVVEEAERSVHDALMVVKDVVQKPAVVAGGGSSEAYIAQKLRAWATGVSGREHYAILGFADAIESIPIALAENAGMDVIDILAEMHSKQLSENNPWMGVDVKGLKLANMSKKNIIEPLEVKEQVLKSATETAAMLLRIDDILSASHTDGGRVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMK7</accession>
    <name>A0A075MMK7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LemA family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NTE_00616</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LemA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699616.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMK7"/>
    <dbReference type="STRING" id="1459636.NTE_00616"/>
    <dbReference type="GeneID" id="41596479"/>
    <dbReference type="KEGG" id="nev:NTE_00616"/>
    <dbReference type="eggNOG" id="arCOG04574">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056714_0_1_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.20">
        <property type="entry name" value="LemA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023353">
        <property type="entry name" value="LemA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007156">
        <property type="entry name" value="MamQ_LemA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34478:SF2">
        <property type="entry name" value="MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34478">
        <property type="entry name" value="PROTEIN LEMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04011">
        <property type="entry name" value="LemA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140478">
        <property type="entry name" value="LemA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF82696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="203" mass="22816" checksum="6448B682C8491E76" modified="2014-10-29" version="1">MVKKSIIVVGAAVGIIAIIFGSLYSMYFSGFNAAQAKDENVKRLASDIDVQLQRRYDLIPNIVRTAQAYLQFEKSVLENVTKLRTDWQRASTVNERVQTSNQIEQALSKILITYENYPQLKSDQQLTRVMDELAGTENRIAVARGNYNDGVRDFNVNLRTFPNNVFNESGFLGTKPWGLQQYASYQATAAAQTTVPQVNIQVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMN0</accession>
    <name>A0A075MMN0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transcription initiation factor TFIIIB, Brf1 subunit/transcription initiation factor TFIIB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NTE_00436</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TFIIB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMN0"/>
    <dbReference type="STRING" id="1459636.NTE_00436"/>
    <dbReference type="KEGG" id="nev:NTE_00436"/>
    <dbReference type="eggNOG" id="arCOG01981">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043736_0_1_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618:SF13">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="Zn_Ribbon_TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51134">
        <property type="entry name" value="ZF_TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIB-type" evidence="7">
        <location>
            <begin position="3"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF82518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="334" mass="37191" checksum="E0A6114CDFB1090B" modified="2014-10-29" version="1">MQTTLVCFACGNELLISDQESGEIVCGYCGVVLAEREEDLAHDARTFFDDFKDGRRTGPRYSLSQNNKGFSTKMGRRIYVSGTLPEGSSIKLRDFGRIKVWDSRIRNSHEKGLRPAFHYLQGIRENLGLPDAVVERSAYFIRKASELGLTKGRTIVSITAASVYLACRESETPRSLAEVAKASNTDRRRLSKDYRLLLRTFNENLPVTSMSRCVTKIANMVGVSESKKRQAIELVNALESVGVSTGKSPLGFAASVIYLVCKNTNEERTQKLLAEVAGVTEVTIRNRYAELVKLITSRKVLVFDASLLSILAPVSVYLVVIAQHMWRHLPVIAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMQ9</accession>
    <name>A0A075MMQ9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6293 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699510.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMQ9"/>
    <dbReference type="GeneID" id="41596355"/>
    <dbReference type="KEGG" id="nev:NTE_00482"/>
    <dbReference type="HOGENOM" id="CLU_1860615_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054162">
        <property type="entry name" value="DUF6293_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22665">
        <property type="entry name" value="WHD_DUF6293"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6293" evidence="1">
        <location>
            <begin position="35"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="137" mass="15231" checksum="E3C8AEE8B996D13F" modified="2014-10-29" version="1">MHALEGDPYYAKLDYEDGGPDKGADKRKVTGTDLLPVCQIHMPSAESLLVLSIISKAGGKMSKKDLIEKLQEVKMIPHYQPSQPRSAPHSRLRAILGPMESNWHFVEVKSRGRRSDVVLTEQGRNALRIFGSGQAEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMW5</accession>
    <name>A0A075MMW5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">UDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NTE_00706</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699688.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMW5"/>
    <dbReference type="STRING" id="1459636.NTE_00706"/>
    <dbReference type="GeneID" id="41596561"/>
    <dbReference type="KEGG" id="nev:NTE_00706"/>
    <dbReference type="eggNOG" id="arCOG01850">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1521919_0_0_2"/>
    <dbReference type="OrthoDB" id="11819at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016410">
        <property type="term" value="F:N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007691">
        <property type="entry name" value="LpxD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43378">
        <property type="entry name" value="UDP-3-O-ACYLGLUCOSAMINE N-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43378:SF2">
        <property type="entry name" value="UDP-3-O-ACYLGLUCOSAMINE N-ACYLTRANSFERASE 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF82786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="179" mass="19031" checksum="7ED7878798E3E3BB" modified="2014-10-29" version="1">MSIENNNISKKFQSQQEAHSYLRTLPMPRPYIHPTAIVENAILGKDVTIAAYAVIGKEGFGFDPQSNYTKRWPHIGNVIIGDNAEIGANTCIDRGTLGSTIIGENTKIDNLVHIGHNATIGKKCVIVAGSVIGGSSVIGDGVFIGMGVKIRDHVTIGDKAFLCMGAVVTKDVSTGAKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMZ1</accession>
    <name>A0A075MMZ1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00758</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699729.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMZ1"/>
    <dbReference type="STRING" id="1459636.NTE_00758"/>
    <dbReference type="GeneID" id="41596609"/>
    <dbReference type="KEGG" id="nev:NTE_00758"/>
    <dbReference type="HOGENOM" id="CLU_1709037_0_0_2"/>
    <dbReference type="OrthoDB" id="382608at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="153" mass="15964" checksum="4E79F8DD71FBF2B9" modified="2014-10-29" version="1">MQSQIIRNKLAGMLAIASGVLFLASGYHPSTAIYDLVAAGLKEYTAKDVWQVAIVPLGLLALVAQLGGIVVIIGGVLFFKNRITTGKFFVMIGTGQGILTIILSLILGLASEGSGFLGNYVLWFTGTAAGIGIICSIISRTIAIAPVKAGQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MN42</accession>
    <name>A0A075MN42_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Phosphate/sulfate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NTE_00865</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Potential transporter for phosphate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987155.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MN42"/>
    <dbReference type="STRING" id="1459636.NTE_00865"/>
    <dbReference type="GeneID" id="41596708"/>
    <dbReference type="KEGG" id="nev:NTE_00865"/>
    <dbReference type="eggNOG" id="arCOG02267">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015355_1_1_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101:SF80">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="263"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIF82941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="336" mass="34836" checksum="35797BB8770BE3BD" modified="2014-10-29" version="1">MADQSIILVVYGAIGAALFFDFVNGFHDAANSIATIVGTRVLRPIQAVGIAAAANFSGPFIFGTAVAATVGKGIIMPEFSTVDVIIAGLLGATAWDLITWWFGLPSSSSHALIGGLVGSALFAGGLQAIVAPGVEKTLTFMVVSPAMGFAVAGGFALAMMYFLRKKVPGRVNRVFGRLQIVSSAFFSLTHGANDGQKTMGIITALLIAGGLMHSKEFVVPLWVIISAASAIALGTFFGGWRIVKTMAFRLTNLKPYQGFCAETGGGAILTSMAWLGIPVSTTHAISGAIMGVGATKRFSAVRWGLGKRIIYAWVITIPASAAIAAACMWAIKALTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MN75</accession>
    <name>A0A075MN75_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MN75"/>
    <dbReference type="KEGG" id="nev:NTE_00915"/>
    <dbReference type="HOGENOM" id="CLU_2091191_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="116" mass="13509" checksum="607B76A314C921A9" modified="2014-10-29" version="1">MHSICYVTTTTAIEDLIWRLEGIWKYAALDYHIRAKGVVSNKSRKANEYAITLMKLWDTLDGFSQETIERVVVELEGKIIVLGKPEGKVEKKRHADMKALRTQLEQYLQVREEEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MN96</accession>
    <name>A0A075MN96_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptide methionine sulfoxide reductase</fullName>
            <ecNumber evidence="6">1.8.4.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NTE_00549</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.8.4.12" evidence="6"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699560.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MN96"/>
    <dbReference type="STRING" id="1459636.NTE_00549"/>
    <dbReference type="GeneID" id="41596417"/>
    <dbReference type="KEGG" id="nev:NTE_00549"/>
    <dbReference type="eggNOG" id="arCOG02815">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031040_8_5_2"/>
    <dbReference type="OrthoDB" id="5961at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033743">
        <property type="term" value="F:peptide-methionine (R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.20">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028427">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002579">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004036">
        <property type="entry name" value="PRK05508.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46081">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46081:SF8">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01641">
        <property type="entry name" value="SelR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51790">
        <property type="entry name" value="MSRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MsrB" evidence="5">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF82630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="129" mass="14674" checksum="183E9E1119F7CB47" modified="2014-10-29" version="1">MSYNNLTPEEERIIVRKGTERPFSGEYDNFYKEGTYVCRRCNQPLFSSKSKFDAGCGWPAFDDSFPNAIKRLPDPDGVRMEIECAKCGAHLGHEFIGEGLTAKNTRECVNSLSIRFIPARGRDKEEDDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MND5</accession>
    <name>A0A075MND5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MND5"/>
    <dbReference type="KEGG" id="nev:NTE_00235"/>
    <dbReference type="HOGENOM" id="CLU_2893044_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="62" mass="6890" checksum="E1A31A725F2E957E" modified="2014-10-29" version="1">MAEKTVNISSLKSPWLSSLRPNSALRALIASEPDVLSCDERIVKLPMLQKIFRYKTSSAQVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNE5</accession>
    <name>A0A075MNE5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Orotidine 5'-phosphate decarboxylase</fullName>
            <ecNumber evidence="3">4.1.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">OMP decarboxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NTE_00653</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>orotidine 5'-phosphate + H(+) = UMP + CO2</text>
            <dbReference type="Rhea" id="RHEA:11596"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="EC" id="4.1.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OMP decarboxylase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.23" evidence="3"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699644.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNE5"/>
    <dbReference type="STRING" id="1459636.NTE_00653"/>
    <dbReference type="GeneID" id="41596514"/>
    <dbReference type="KEGG" id="nev:NTE_00653"/>
    <dbReference type="eggNOG" id="arCOG00081">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067069_2_0_2"/>
    <dbReference type="OrthoDB" id="94124at2157"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04725">
        <property type="entry name" value="OMP_decarboxylase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011995">
        <property type="entry name" value="OMPdecase_type-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001754">
        <property type="entry name" value="OMPdeCOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43375">
        <property type="entry name" value="OROTIDINE 5'-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43375:SF1">
        <property type="entry name" value="OROTIDINE 5'-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00215">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00934">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="7 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orotidine 5'-phosphate decarboxylase" evidence="10">
        <location>
            <begin position="19"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIF82733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="251" mass="27090" checksum="41158ACAF3829D55" modified="2014-10-29" version="1">MTSSFSQRMAQLARKKKSRIVVALDPAANKRSLKQFAIRTIDAVAGDACAVKMNFHLLLPLSSREISEITKRAHSRRLLCIADIKLNDIGDTNEVALEHLARMGFDAVIANPFMGANTLALLANKARALGMGVIALVYMSHPDAADGYGLQAYGDMMYRIFLDRAIKAKVDGIVVGATQTDILEEVSEKKKELQISLPVYSPGVGAQGGDARQAVESGSDYLIIGRSIVQAKDQAVAARWFRLLAASPSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNG8</accession>
    <name>A0A075MNG8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Orotate phosphoribosyltransferase</fullName>
            <shortName evidence="6">OPRT</shortName>
            <shortName evidence="6">OPRTase</shortName>
            <ecNumber evidence="2 6">2.4.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pyrE</name>
        <name evidence="8" type="ORF">NTE_00615</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate</text>
            <dbReference type="Rhea" id="RHEA:10380"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.10" evidence="2 6"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNG8"/>
    <dbReference type="STRING" id="1459636.NTE_00615"/>
    <dbReference type="KEGG" id="nev:NTE_00615"/>
    <dbReference type="eggNOG" id="arCOG00029">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074878_0_1_2"/>
    <dbReference type="OrthoDB" id="9089at2157"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019856">
        <property type="term" value="P:pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01208">
        <property type="entry name" value="PyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023031">
        <property type="entry name" value="OPRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004467">
        <property type="entry name" value="Or_phspho_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00336">
        <property type="entry name" value="pyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19278">
        <property type="entry name" value="OROTATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19278:SF9">
        <property type="entry name" value="URIDINE 5'-MONOPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 6" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="7">
        <location>
            <begin position="75"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="6">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="6">
        <location>
            <begin position="138"/>
            <end position="146"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>orotate</name>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>orotate</name>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF82695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="225" mass="23914" checksum="552C3D837AF5EF84" modified="2014-10-29" version="1">MTKDKNESLADQHIVSSSSSDFTLEFASFLLKSNALKFGAFTLASGKPSPYYIDLRMLPSFPAHFRLTIGALKDVVAKKMPSFDTFASVPTSGLVFGSALAYEMEKPFVYVRKESKGYGMSKLVEGHLASGAKVVIVDDVATTGLSVSKAIDALRANGGVVEDVVAVVNRMEGAEEKLKQMGVRLVSVATIQDIASSLHRAGLVDDSTMDAVVKQIAASGGLETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNH7</accession>
    <name>A0A075MNH7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fibrillarin-like rRNA/tRNA 2'-O-methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">flpA</name>
        <name evidence="8" type="ORF">NTE_00625</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the methyltransferase superfamily. Fibrillarin family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="7"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNH7"/>
    <dbReference type="STRING" id="1459636.NTE_00625"/>
    <dbReference type="KEGG" id="nev:NTE_00625"/>
    <dbReference type="eggNOG" id="arCOG00078">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059055_2_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990259">
        <property type="term" value="F:histone H2AQ104 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008649">
        <property type="term" value="F:rRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000494">
        <property type="term" value="P:box C/D sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00351">
        <property type="entry name" value="RNA_methyltransf_FlpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000692">
        <property type="entry name" value="Fibrillarin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003276">
        <property type="entry name" value="PRK04266.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335:SF17">
        <property type="entry name" value="FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335">
        <property type="entry name" value="RRNA 2-O-METHYLTRANSFERASE FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01269">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006540">
        <property type="entry name" value="Nop17p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00052">
        <property type="entry name" value="FIBRILLARIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01206">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 7 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 7" id="KW-0819">tRNA processing</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="92"/>
            <end position="93"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="111"/>
            <end position="112"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="137"/>
            <end position="138"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="157"/>
            <end position="160"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF82705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="236" mass="25856" checksum="DFC85213F5837B8F" modified="2014-10-29" version="1">MAAARRRERTESALESDGIKWIFAGGEKHAATVNLVPGDSVYGEKLVKQGGEEYRLWDPFRSKLAGALKKGLRNLPIKNGTKVLYLGASTGTTVSHVSDIVGNSGIVFAVEPATRVARELIENVASKRKNVVPVLEDARRPNSYFSVFGKVDVVYCDIAQPDQTEIAIANCNAYLKPGGVMLLVVKTRSIDVLMDPKAVVVQEAKKLEKAGFAIDQVLNLEPFDKDHGMIYCFFRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNJ8</accession>
    <name>A0A075MNJ8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00698</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNJ8"/>
    <dbReference type="KEGG" id="nev:NTE_00698"/>
    <dbReference type="HOGENOM" id="CLU_2712606_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="72" mass="8164" checksum="1EB8D09F5BC95EEE" modified="2014-10-29" version="1">MPAPNYVIETPKSIEQLFRYSYAGGREATAGQETDMQLAIQMLMETGLGFMTLTMIYAEEIMEMSHRQNAII</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNP6</accession>
    <name>A0A075MNP6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">(S)-ureidoglycine aminohydrolase cupin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_00350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNP6"/>
    <dbReference type="KEGG" id="nev:NTE_00350"/>
    <dbReference type="eggNOG" id="arCOG03003">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_166867_0_0_2"/>
    <dbReference type="OrthoDB" id="189706at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06990">
        <property type="entry name" value="cupin_DUF861"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008579">
        <property type="entry name" value="UGlyAH_Cupin_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05899">
        <property type="entry name" value="Cupin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="(S)-ureidoglycine aminohydrolase cupin" evidence="2">
        <location>
            <begin position="59"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF82432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="120" mass="13130" checksum="6E552BBC0781A682" modified="2014-10-29" version="1">MVEMQRKSMSSPDETRKFDNGKIDLTNLGEATIGKATFEPGWKWSTSVKPIVKTDSCKQSHTMYVISGRMKVRMDDGSEQEFSAGDTGLVPPGHDAWVVGNEPCVAIDFTGAKTYAQGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNX5</accession>
    <name>A0A075MNX5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative metal-dependent phosphoesterase, PHP family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00842</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNX5"/>
    <dbReference type="STRING" id="1459636.NTE_00842"/>
    <dbReference type="KEGG" id="nev:NTE_00842"/>
    <dbReference type="eggNOG" id="arCOG00302">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072983_3_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07432">
        <property type="entry name" value="PHP_HisPPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052018">
        <property type="entry name" value="PHP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42924">
        <property type="entry name" value="EXONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42924:SF3">
        <property type="entry name" value="POLYMERASE_HISTIDINOL PHOSPHATASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13263">
        <property type="entry name" value="PHP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="PHP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="358" mass="41033" checksum="1AFB2D08C9063BA2" modified="2014-10-29" version="1">MRPLIVLPVFIIEQWILSNKNVRYPDRIIAIMLIFMWQCHYRRQGRDATTTTGVLNAELHCHNTFSNHQNGSARVPFDCGVEMAAQLEAALARGIDVLFVTNHNTLDGYRQILEYQANHAKFQKITIYPAEEVTIDTGGHVLAYGIYRTIRPGMTLDETLDEIKRQGAVSCAAHPFAVSNGIREKALYCDMIESFNSNNVDRFSNIVASKFAHDNSMSEVAGSDSHVLSTLGKCVNTIEAENNLDSVLDAMLHRRIKMVCREYASHDELYEHAYYIVQSSRELLLRHALENHPRFYWVLKWALDSYLGDYKSMLWRSVAAFSLYLTKRVSEKVNMKGHSPHVFSNRQWMKLIKMSLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNY2</accession>
    <name>A0A075MNY2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNY2"/>
    <dbReference type="KEGG" id="nev:NTE_01158"/>
    <dbReference type="HOGENOM" id="CLU_2613422_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="19"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="78" mass="8797" checksum="F991BA00C2BCBD86" modified="2014-10-29" version="1">MFGIGVNVVSETKGGTVICELCGATFNTVEERWKHNEQEHPKEMAKMLESLSHVLEEKGVIDKADWDKKRKEMIAAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MP01</accession>
    <name>A0A075MP01_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01178</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700047.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MP01"/>
    <dbReference type="STRING" id="1459636.NTE_01178"/>
    <dbReference type="GeneID" id="41596989"/>
    <dbReference type="KEGG" id="nev:NTE_01178"/>
    <dbReference type="HOGENOM" id="CLU_2930026_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="60" mass="6938" checksum="6D22196BB5C13F39" modified="2014-10-29" version="1">MKEETVMEYFAKVKEALDAPSHLYELDINSLFGPPVLRQAEKPKKMIKCPHCNWDFAPDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MP02</accession>
    <name>A0A075MP02_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00867</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699811.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MP02"/>
    <dbReference type="STRING" id="1459636.NTE_00867"/>
    <dbReference type="GeneID" id="41596710"/>
    <dbReference type="KEGG" id="nev:NTE_00867"/>
    <dbReference type="HOGENOM" id="CLU_1514666_0_0_2"/>
    <dbReference type="OrthoDB" id="6145at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="157" mass="18001" checksum="7664448FE818E095" modified="2014-10-29" version="1">MGHAFEDGSLGLKLKGYLIVPNDALENKIAVYTLRIAQDILSDNPEIVDEWLRKIHEDYMTKKRACDFENDPVACFNLSAYEEFEKHLKSWDDGGMLAISLPGNRTIRVSKRPLFSVSKSPAESCEECRMTFATVKELVRHYREKHPAMIERVTIPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPJ0</accession>
    <name>A0A075MPJ0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">C2H2 type zinc finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01411</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPJ0"/>
    <dbReference type="STRING" id="1459636.NTE_01411"/>
    <dbReference type="KEGG" id="nev:NTE_01411"/>
    <dbReference type="eggNOG" id="arCOG10404">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_154322_0_0_2"/>
    <dbReference type="OrthoDB" id="11939at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="PRC-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="137" mass="16208" checksum="6FD5E095D21C73B6" modified="2014-10-29" version="1">MINESVHTSDDQDIGDVEAVSRHFIVVKRGFVHVHRYYIPISKVEGWDGDVLWLRISEDHVKRSYERNVYPDPYRYYVKDHPYYEAGYSPFLTIPRKYEPPIYSGATAPTKFIYKCDICDKEFPTADDFEQHVKMAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPM0</accession>
    <name>A0A075MPM0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RecF/RecN/SMC N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_00692</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699675.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPM0"/>
    <dbReference type="STRING" id="1459636.NTE_00692"/>
    <dbReference type="GeneID" id="41596548"/>
    <dbReference type="KEGG" id="nev:NTE_00692"/>
    <dbReference type="eggNOG" id="arCOG00368">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004785_0_2_2"/>
    <dbReference type="OrthoDB" id="25344at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32114">
        <property type="entry name" value="ABC TRANSPORTER ABCH.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32114:SF2">
        <property type="entry name" value="ABC TRANSPORTER ABCH.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75712">
        <property type="entry name" value="Rad50 coiled-coil Zn hook"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecF/RecN/SMC N-terminal" evidence="3">
        <location>
            <begin position="1"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="208"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="377"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="499"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF82772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="705" mass="78598" checksum="3449FC7EF92EC9AE" modified="2014-10-29" version="1">MIKDLEMKDFISHKDTRLEFGKGITIFVGHNGAGKSSVIDAITFALFAEHMRRTNKNLVRRGSGTGSAMVRMRFSLNSKEFQATRSVSAAGSASFSQLELVSEGGKSVSKKLAGGERRQFGESMSVEVAKVLGLDYKKLQVAAVVQQGELARIVEAQPKEFKELLNGLIGIDRLDLAFATMKDVISGFRLRLKSEIAPDRGGYTDEDLPRVKSQISEAEKKLAESERLAGEYLDEKVRQDKMLQEIDREIEAMEPLREKAAEVQAKEKRLVRYIAEKRDQVGAELARMERVVREARGALALLERKEEACMRLQMVKYELEEVQKQIEVKERQAGKLRGFVECASKIKIVDGRCPVCNSVVVSKINEMFDGEHIQSDIRKIENDKSALQAERISLKKEEQKLTEEAKAIAGAESFLSANSIKTVDDVVRIESELGPKKKAILRLPKSVASVGSDPLQLAIDEVSRSFADEIVSLRALTRSFSMARYTAAKDDRWNTVQKLQSISSKLGAYQNAVQELKQAIDSDRKSLQELEHASEIVRMLERIRSTVYNRDGSVGMSLRSWALAVISRKASEYAALFNIGISRIELTEKAREIAITCYGKNGEVDMDSLSGGEKVAVALALRLGIAQMMGSNKLDFVILDEPTTHLDDERRKALVKIISEAFREGSGPLSQMIIITHDAEIFEDSEVDAVFRFTMTTEGSRVVQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPM4</accession>
    <name>A0A075MPM4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00697</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPM4"/>
    <dbReference type="KEGG" id="nev:NTE_00697"/>
    <dbReference type="HOGENOM" id="CLU_3147797_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="48" mass="5408" checksum="5885AD989202A85E" modified="2014-10-29" version="1">MLCVSPNQSKSGTGIVTTGRRHLLSIFHMLMVVVVLKHIRALYQIKET</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPS9</accession>
    <name>A0A075MPS9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Single-stranded DNA-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01057</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385108.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPS9"/>
    <dbReference type="STRING" id="1459636.NTE_01057"/>
    <dbReference type="GeneID" id="43502590"/>
    <dbReference type="KEGG" id="nev:NTE_01057"/>
    <dbReference type="eggNOG" id="arCOG01510">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_577000_0_0_2"/>
    <dbReference type="OrthoDB" id="6262at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010212">
        <property type="term" value="P:response to ionizing radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04491">
        <property type="entry name" value="SoSSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051231">
        <property type="entry name" value="SOSS-B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13356">
        <property type="entry name" value="OB FOLD NUCLEIC ACID BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13356:SF0">
        <property type="entry name" value="SOSS COMPLEX SUBUNIT B HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="482" mass="51808" checksum="15B75711F7F14D70" modified="2014-10-29" version="1">MSPSFIDMVNVLLKQKPGLTAEAIRDMVDEKKRKVGAGYLTDQGALFLVAADLGISFDSVPKMQSGLKDLYVGAKDVTITGRIMNIYPPFKFTRKETNEQSSTRTLVIYDKEARVKVKLWDKQVSVPDEMGLQAGDLVKIVKGYVRAGLDGKPIVNLGSYSAIEVAQGDSDIPPLDSLAMTVDDVKEVQDSAVITGVVNANPRISDFVNQRGEASKSLQLQISNEANTRTLRAVVWNVDESRVPKVFRTGSKVKLVGVRVKQGNPQFGNGDFELHGDEGTILEFSGSQQDVDVMPLRIISVGEETGRGSFLCLAVDRAARALTLTIDNNVASPDQLSAGTMIECVPSRIFGNAVTLSKEDSYLRITDDDPSFPSLGKFEAKIKDITAVTGEPAPVVLEAIVLQAPSTSDVNLKSGETVPVTSTLLGDDTGQIRLVGWRNQSSAVNKLAVGDRVKLVGVTAGAGREGAPELTLRSYSSVIHLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPX2</accession>
    <name>A0A075MPX2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01553</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700355.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPX2"/>
    <dbReference type="STRING" id="1459636.NTE_01553"/>
    <dbReference type="GeneID" id="41597335"/>
    <dbReference type="KEGG" id="nev:NTE_01553"/>
    <dbReference type="eggNOG" id="arCOG12283">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2191109_0_0_2"/>
    <dbReference type="OrthoDB" id="6894at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="108" mass="12330" checksum="6FD7BF63B2CD49C5" modified="2014-10-29" version="1">MPELVYLKYEDLDDMLKVIIYSAQSMLGVIPMLYHINHADKHVLFIQTGTIGNATIHYFVQNEKPPKKFIQLKRLSGDYAYVEGIGTDAQSLYVPVLKLVKSTLEFPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPX8</accession>
    <name>A0A075MPX8_9ARCH</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700025.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPX8"/>
    <dbReference type="GeneID" id="41596967"/>
    <dbReference type="KEGG" id="nev:NTE_01155"/>
    <dbReference type="HOGENOM" id="CLU_2433697_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="90" mass="10218" checksum="E6F332CD1A96F90C" modified="2014-10-29" version="1">MTEEKEDNNTSTNSSMMKRVTWQSENCLSCKWFSPSDPLNADILSTGKCVHPSLQKFKLTVSGRDWCNLFVEISQEQIDQMQEKAAGAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQ03</accession>
    <name>A0A075MQ03_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha-aminoadipate carrier protein LysW</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01583</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700378.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQ03"/>
    <dbReference type="STRING" id="1459636.NTE_01583"/>
    <dbReference type="GeneID" id="41597363"/>
    <dbReference type="KEGG" id="nev:NTE_01583"/>
    <dbReference type="eggNOG" id="arCOG01588">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_195720_1_0_2"/>
    <dbReference type="OrthoDB" id="159847at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd13946">
        <property type="entry name" value="LysW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005906">
        <property type="entry name" value="LysW"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041070">
        <property type="entry name" value="carrier_LysW_Arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40393:SF2">
        <property type="entry name" value="ALPHA-AMINOADIPATE_GLUTAMATE CARRIER PROTEIN LYSW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40393">
        <property type="entry name" value="LYSINE BIOSYNTHESIS PROTEIN-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21344">
        <property type="entry name" value="Zn_ribbon_LysW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="56" mass="5858" checksum="1B5335086EB4C404" modified="2014-10-29" version="1">MVNCPECDAEIKIPADSIEGEIVTCPDCGASYELVKAASGGFDIKPAQVVGEDWGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQ24</accession>
    <name>A0A075MQ24_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PhnB-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01132</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
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            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
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            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700015.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQ24"/>
    <dbReference type="STRING" id="1459636.NTE_01132"/>
    <dbReference type="GeneID" id="41596946"/>
    <dbReference type="KEGG" id="nev:NTE_01132"/>
    <dbReference type="eggNOG" id="arCOG09469">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046006_22_1_2"/>
    <dbReference type="OrthoDB" id="7844at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06588">
        <property type="entry name" value="PhnB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009725">
        <property type="entry name" value="3_dmu_93_MTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028973">
        <property type="entry name" value="PhnB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33990:SF2">
        <property type="entry name" value="PHNB-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33990">
        <property type="entry name" value="PROTEIN YJDN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06983">
        <property type="entry name" value="3-dmu-9_3-mt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021700">
        <property type="entry name" value="3_dmu_93_MTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhnB-like" evidence="1">
        <location>
            <begin position="7"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="159" mass="18226" checksum="BC05C2BBA9D88233" modified="2014-10-29" version="1">MSKAIVQKITPHLWFDKEAKEATEFYVSIFPNSRITNVTTIHNTPSSDCDIVSFELSGQPFMAISAGPFFKFNESISFMVHCDTQEEIDYYWQKLSAVPEAEQCGWLKDKYGLSWQVVPTVMGEMMKDKDEKKIARVTEAFLKMKKFDIATLQKAYAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQ37</accession>
    <name>A0A075MQ37_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQ37"/>
    <dbReference type="STRING" id="1459636.NTE_01216"/>
    <dbReference type="KEGG" id="nev:NTE_01216"/>
    <dbReference type="HOGENOM" id="CLU_2662139_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="49"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="75" mass="7925" checksum="F1A4C8FE491AC841" modified="2014-10-29" version="1">MNMSERSSLNISPATKELVAQCGIVSESYDQVLQKIAKFYLANAGTKHVVSKENGQSAPNTPANTTPIGETGDAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQ71</accession>
    <name>A0A075MQ71_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00952</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699878.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQ71"/>
    <dbReference type="GeneID" id="41596787"/>
    <dbReference type="KEGG" id="nev:NTE_00952"/>
    <dbReference type="HOGENOM" id="CLU_2079309_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="117" mass="13110" checksum="344DD1C8EB1F9BE9" modified="2014-10-29" version="1">MRKRDTGAHKPKTAKSSKGFAADDLIMHQETKAKGAYTVKKLGQQEYLYHITRVAGKQKWRLLGNVKDIDAKDPNLIKARAVTALPYARSVIERYLAGDIDKAKAKSELARVIDKCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQH3</accession>
    <name>A0A075MQH3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Copper-containing nitrite reductase</fullName>
            <ecNumber evidence="3">1.7.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">NTE_01403</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>nitric oxide + Fe(III)-[cytochrome c] + H2O = Fe(II)-[cytochrome c] + nitrite + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15233"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.7.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Cu(+)</name>
            <dbReference type="ChEBI" id="CHEBI:49552"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotrimer.</text>
    </comment>
    <dbReference type="EC" id="1.7.2.1" evidence="3"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700233.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQH3"/>
    <dbReference type="STRING" id="1459636.NTE_01403"/>
    <dbReference type="GeneID" id="41597197"/>
    <dbReference type="KEGG" id="nev:NTE_01403"/>
    <dbReference type="eggNOG" id="arCOG03914">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031740_1_1_2"/>
    <dbReference type="OrthoDB" id="12293at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050421">
        <property type="term" value="F:nitrite reductase (NO-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001287">
        <property type="entry name" value="NO2-reductase_Cu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF394">
        <property type="entry name" value="FI03373P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00695">
        <property type="entry name" value="CUNO2RDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 10" id="KW-0186">Copper</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="12">
        <location>
            <begin position="66"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="357"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="358"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="binding site" description="type 1 copper site" evidence="10">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="type 1 copper site" evidence="10">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="type 1 copper site" evidence="10">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="type 1 copper site" evidence="10">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="type 1 copper site" evidence="10">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="type 1 copper site" evidence="10">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="type 1 copper site" evidence="10">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601287-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIF83468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="392" mass="40890" checksum="AA5596681690C95A" modified="2014-10-29" version="1">MNKAIIAGLAAGVLVVGLIFSPLFNGFPLSAAQAAPTGVTRHYTLIANEKVVQVAPDDALHPGGIMYNAMVFNGTIPGPVMASNVGDTVEITLKNEGKQIHSIDFHAAIGPSQVLSGNVAPGESKTWTFNTPNSGAFLYHCGADGLNGVWEHIANGMYGGFVVHPTNEAPAKEFYVVFGEIYNSADGGLFVGANKTGSFDITKFATEQPDLILTNGMAHKYAPAVGQAVKLTLNANATLFKVKPGELTRWYIVAPGPNEGVSFHFISGQIDVKDGSFKGRGMTQERNEETWWVPVGSASVIESTFPEEGIYVGVDHNMAHVVRGGAFVVQATNNSTADDVPPEAWVPSKAWLTEHPTMGGSMTGGSAMEGSSGNATSSGGNATSSGGNTTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MR12</accession>
    <name>A0A075MR12_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Site-specific recombinase XerD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_01179</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700048.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MR12"/>
    <dbReference type="STRING" id="1459636.NTE_01179"/>
    <dbReference type="GeneID" id="41596990"/>
    <dbReference type="KEGG" id="nev:NTE_01179"/>
    <dbReference type="eggNOG" id="arCOG01245">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_890265_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00397">
        <property type="entry name" value="DNA_BRE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="2">
        <location>
            <begin position="112"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF83252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="312" mass="35520" checksum="2C8DA518620253A3" modified="2014-10-29" version="1">MAQALAESVSVAQLLERLCKTEDTWRNYTGAVEGFIEYRNVDSWADLLQGEPKVIEDSIIAYFQKLEDDGLSPSYKNVIRAGLQKFYVSQRARLDWDYIKSQIVSKNPDSVGLDRAYTKAEIALLLKHADLKLRATILLLATTGMRVEALCELKYKHLRPVLKFDLLYIKIYAGTNTEYDAFASKNCLAAVRAWLQSLKEEIGRELSDEDYIFPGNETGEHITKKAIESAIVRLIKKAGIAREKISKRRYDIAPCHSFRKYFSSTLESTHMPHGLKEALMGHFSGVQGRYRRPPIQKLLMAYVEYGGVLDIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MR15</accession>
    <name>A0A075MR15_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glucose/sorbosone dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_01932</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226986926.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MR15"/>
    <dbReference type="GeneID" id="41597681"/>
    <dbReference type="KEGG" id="nev:NTE_01932"/>
    <dbReference type="eggNOG" id="arCOG02796">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_677373_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012938">
        <property type="entry name" value="Glc/Sorbosone_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH_b-prop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19328:SF75">
        <property type="entry name" value="ALDOSE SUGAR DEHYDROGENASE YLII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19328">
        <property type="entry name" value="HEDGEHOG-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07995">
        <property type="entry name" value="GSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="Soluble quinoprotein glucose dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose/Sorbosone dehydrogenase" evidence="2">
        <location>
            <begin position="88"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF83991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="441" mass="47257" checksum="B9F1198FBA203D7D" modified="2014-10-29" version="1">MRKAIIQAVRRAVFAVAGAIIVAAAIAAVAGTWQTRAIPGITGDNIVTPTDITFTATKAGDPFKAIPDSSLPRLRDPSLKVEKVIDGLTEPTSMTFVGNNNVLVTQKGGDVRLVRDGALQQGPPLLSFKVETASERGLLGVAYAKDKVFLYMTEQSGLDIRNRVYSYDLQNGTLSGNSTKKMILDLPGTPGPNHDGGKIIVGPDGYLYIVIGDLNRNGMLQNYKNGAVPDNTSVILKVGLDGAPAANILSGAGGLEGYYAYGIRNSFGMDFDPRNGKLWATENGPDRYDEVNVAEPGFNSGWERVMGPISRSQQQVSEGDLVMFNGAHYSDPVFSWRQSMGVTDIEFLNSTKLGDKYAYNVFVGDVNNGNLYYFTVNGKRDGFTLEGNLSDRVADNDAEGSAITLGTAFGGITDIETGPDGYLYILSYGKGSIYRIVPAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MR33</accession>
    <name>A0A075MR33_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14 15">Shikimate kinase</fullName>
            <shortName evidence="14">SK</shortName>
            <ecNumber evidence="4 14 15">2.7.1.71</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">aroK</name>
        <name evidence="18" type="ORF">NTE_01953</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>shikimate + ATP = 3-phosphoshikimate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13121"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.71"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the GHMP kinase family. Archaeal shikimate kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.71" evidence="4 14 15"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385305.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MR33"/>
    <dbReference type="STRING" id="1459636.NTE_01953"/>
    <dbReference type="GeneID" id="41597700"/>
    <dbReference type="KEGG" id="nev:NTE_01953"/>
    <dbReference type="eggNOG" id="arCOG01025">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073768_0_0_2"/>
    <dbReference type="OrthoDB" id="9602at2157"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00088"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004765">
        <property type="term" value="F:shikimate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00370">
        <property type="entry name" value="Shik_kinase_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010189">
        <property type="entry name" value="SK_arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01920">
        <property type="entry name" value="Shik_kin_archae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20861">
        <property type="entry name" value="HOMOSERINE/4-DIPHOSPHOCYTIDYL-2-C-METHYL-D-ERYTHRITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20861:SF3">
        <property type="entry name" value="SHIKIMATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005758">
        <property type="entry name" value="Shikimt_kin_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12 14" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="11 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 14 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 14 18" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="16">
        <location>
            <begin position="74"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="17">
        <location>
            <begin position="207"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="NCBIfam" id="TIGR01920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="AIF84011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="284" mass="30077" checksum="3F1C54E0CA76B66D" modified="2014-10-29" version="1">MTVSKVRATMHGAVSIVNAIATGNGSALGISLKVTAEVEMTKGRGLRFLTGKNDDRLVNNIIKNTMPAGTLERNQLIVKLRSEIPIGFGLKSSSAVSNAVALACSRLANEKVDDYAVLDAAVRASLDAKVTITGAYDDATACYFGGFVVTDNYAKKLLRREEAPDNLHAVIFLPRNTPRGDVHKLSDLSDLFTDAFGLAEAGEYWKAMKLNGVLASTALGANYKPVLAALEQGALAAGMSGNGPSIAAVAYDDEVEDIKNAFLKFNGRVLVSKVNNQKASVEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MR43</accession>
    <name>A0A075MR43_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TPR repeat</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_01968</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226986931.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MR43"/>
    <dbReference type="STRING" id="1459636.NTE_01968"/>
    <dbReference type="GeneID" id="41597716"/>
    <dbReference type="KEGG" id="nev:NTE_01968"/>
    <dbReference type="eggNOG" id="arCOG03032">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_870458_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050498">
        <property type="entry name" value="Ycf3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44858">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44858:SF1">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANSFERASE SPINDLY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13371">
        <property type="entry name" value="TPR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="241"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF84026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="322" mass="36142" checksum="A73EF2118A14BF67" modified="2014-10-29" version="1">MESSQPEHFISLPLVSKGEESPRLPLAINVVAKYWGEDLAAAEEGSQQGQQQQAPRGAVMIIDGIELAESHGLACYVFRGSLKDIKKRIDQGIPPIVVMPGIHDIAQHATVISGYDLDERRILTYVPEPDTIGAIPEQKFEQDWEQDDMTEIILIPADMKKDLMKNEDLKFAKSNRACFEAERLRQEGKTEKAVEKLRQAAEAEPENAQAWSQLAGIYNEQGSEQAVVCYERAIKTNPRYYLAYRGLGNYYLKKKDYSLAEAYYTKAIGINPTRYGPIYKNRAVARMQNGNNAGAKEDLARYLEQTPNAADRESVKEAIAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MR61</accession>
    <name>A0A075MR61_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aconitase</fullName>
            <ecNumber evidence="8">4.2.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NTE_01231</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.2.1.3" evidence="8"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700093.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MR61"/>
    <dbReference type="STRING" id="1459636.NTE_01231"/>
    <dbReference type="GeneID" id="41597039"/>
    <dbReference type="KEGG" id="nev:NTE_01231"/>
    <dbReference type="eggNOG" id="arCOG01697">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006714_2_2_2"/>
    <dbReference type="OrthoDB" id="255at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.19.10:FF:000002">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000003">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000004">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1060.10:FF:000001">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1060.10">
        <property type="entry name" value="Aconitase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050926">
        <property type="entry name" value="Aconitase/IPM_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015932">
        <property type="entry name" value="Aconitase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006248">
        <property type="entry name" value="Aconitase_mito-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01340">
        <property type="entry name" value="aconitase_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005558">
        <property type="entry name" value="PRK07229.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160">
        <property type="entry name" value="ACONITATE HYDRATASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160:SF4">
        <property type="entry name" value="ACONITATE HYDRATASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="6">
        <location>
            <begin position="44"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="7">
        <location>
            <begin position="566"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF83302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="762" mass="83135" checksum="21DCBB2CB3EE6BD4" modified="2014-10-29" version="1">MSSEEAAKIETTPELVGRVYSKLEANIAKFRKMTNNRPLTLAEKILVGHLDGDNVYDPQRGKSYVFLNPDRVALQDVTGQMTILQFAQAGLKRVKLPTTVHCDHLIQAKVDSATDTRFAIIQNNEVFQFLESACRKYGIGFWKPGAGIIHQVVLENYAFPGGLMIGTDSHTPNAGGLGMIAIGVGGLDAAEVMAGMPWELLYPKRIGVYLTGELNGWAAPKDIILYVASKLTVSGGTNAIIEYFGPGARSISCTGKATITNMGAEIGATCSVFAYDERMEAYLRATNRGAIADLANKHKALLTEDPEVEKDPQKYFDQVIEIDLSRLEPHIVGPHTPDLARPISQMAADVKKNNYLDSISVALIGSCTNSSYEDMSRAADIAKQAKAHGMKTPVSLQVTPGSEMIRATIERDGQMKVLQDIGANVLANACGPCIGQWSRPELKKGEPNTIVTSYNRNFPGRNDGRRETMNFIGSPELVIALALGGRLSFNPLTDELTAPDGTKFRLQPPGQAPEVPKDGFQNAKDVYVPPAADPDSVRVVIDPKSDRLQKLEPFAPWDGRDFEKLPVLAKTKGKTTTDHISPAGAWLTYRGHLDRISDNLLLGAVNAYSGQVGNGKNQLDSQVESFPRIARQYKAKGIKWIIVGDSNYGEGSSREHAAMTPRYLNCAAVIARSFARIHETNLKKQGVLALTFANPADYDKILEDDRLSIVGLKDMQAGKPVKCIITHAADGRIEEIELKHSYNSAQIEWFKAGSALNLMRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRA0</accession>
    <name>A0A075MRA0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02024</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700725.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRA0"/>
    <dbReference type="GeneID" id="41597767"/>
    <dbReference type="KEGG" id="nev:NTE_02024"/>
    <dbReference type="HOGENOM" id="CLU_1492922_0_0_2"/>
    <dbReference type="OrthoDB" id="373663at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="180" mass="20494" checksum="74426BB2B580D290" modified="2014-10-29" version="1">MATVYTELFQRECENRFGVTRDLVRDAIAQPDKEQRLASQGLTLILYSKKIPGSDDYLVVSTHVQGQDLMVDLAFRLKKDLVDEAKTTLPFPLLQALALQFGLPVKIGDREGKFVYNEIIPTTSRDVKKVLRINNPDGRPLVSSIWVRMLQNNMGFLAQCALVFCIDSQAYASWLEKKQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRI8</accession>
    <name>A0A075MRI8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01639</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700424.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRI8"/>
    <dbReference type="STRING" id="1459636.NTE_01639"/>
    <dbReference type="GeneID" id="41597415"/>
    <dbReference type="KEGG" id="nev:NTE_01639"/>
    <dbReference type="eggNOG" id="arCOG07440">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_184938_0_0_2"/>
    <dbReference type="OrthoDB" id="31361at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="97" mass="10868" checksum="2C1E0906BF338815" modified="2014-10-29" version="1">MSDALPEGVKHLVPIVPVEKAPKITEQAKEELKSVGMMDEKGKLKIKGVSPKMLKRMKQEQVACPVLKQDIAFVQCYVCRNFHSRISGQVYCKGEPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRK5</accession>
    <name>A0A075MRK5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700217.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRK5"/>
    <dbReference type="STRING" id="1459636.NTE_01380"/>
    <dbReference type="GeneID" id="41597176"/>
    <dbReference type="KEGG" id="nev:NTE_01380"/>
    <dbReference type="eggNOG" id="arCOG08734">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1292063_0_0_2"/>
    <dbReference type="OrthoDB" id="10526at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="206" mass="23112" checksum="D4E5385518D1BD36" modified="2014-10-29" version="1">MFAADAGSERATNIEDYQNTCTEFIIDISRDYKDWVDRYQLGEQETARRKGVIENIVKTTNDWINRFGTTIKKVDIIMNDGVNKMAENTAGYPFGFEALVLGKSRYATHPVGDVRINVKAVPRPGRLVRIGNYQKDELLLLSASAQVGFSLSQESRKGADILDDYIIIDAKNCQRGDVLSLTVVVEEMQDDYVAESRGYSTLVLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRP1</accession>
    <name>A0A075MRP1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin-like fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01679</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385249.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRP1"/>
    <dbReference type="STRING" id="1459636.NTE_01679"/>
    <dbReference type="GeneID" id="41597452"/>
    <dbReference type="KEGG" id="nev:NTE_01679"/>
    <dbReference type="eggNOG" id="arCOG03842">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1313076_0_0_2"/>
    <dbReference type="OrthoDB" id="5970at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009272">
        <property type="entry name" value="DUF929"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06053">
        <property type="entry name" value="DUF929"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="209" mass="22947" checksum="E8B7785F66817F0C" modified="2014-10-29" version="1">MAPPSYVSFVPKRVLGKFMHVTDQPLKRPGGKSLVYFMGAGFCPFCAAERWAIVKALERFGKWEGLVEDKSAGHDEKYLNVPTFNLARAKYASDAVEFAGKETADRNFEPLQELDDKDYEILDMYNPDQMIPFLLIDGQYMQVGAGYSPELIQNMTHDKVKAELGNPNSAIGKAINAEIDNITALICKATGGKGSACNSDSVKALTAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRW6</accession>
    <name>A0A075MRW6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Homoserine dehydrogenase</fullName>
            <ecNumber evidence="4">1.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">NTE_01853</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SR1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 3/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the homoserine dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.3" evidence="4"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700599.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRW6"/>
    <dbReference type="STRING" id="1459636.NTE_01853"/>
    <dbReference type="GeneID" id="41597617"/>
    <dbReference type="KEGG" id="nev:NTE_01853"/>
    <dbReference type="eggNOG" id="arCOG01351">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009116_1_2_2"/>
    <dbReference type="OrthoDB" id="4488at2157"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00063"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004412">
        <property type="term" value="F:homoserine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000005">
        <property type="entry name" value="Homoserine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000554">
        <property type="entry name" value="Homoserine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005106">
        <property type="entry name" value="Asp/hSer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001342">
        <property type="entry name" value="HDH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022697">
        <property type="entry name" value="HDH_short"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004912">
        <property type="entry name" value="PRK06270.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004976">
        <property type="entry name" value="PRK06349.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43331">
        <property type="entry name" value="HOMOSERINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43331:SF1">
        <property type="entry name" value="HOMOSERINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00742">
        <property type="entry name" value="Homoserine_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03447">
        <property type="entry name" value="NAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036497">
        <property type="entry name" value="HDH_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="11" id="KW-0521">NADP</keyword>
    <keyword evidence="8 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Aspartate/homoserine dehydrogenase NAD-binding" evidence="13">
        <location>
            <begin position="7"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Homoserine dehydrogenase catalytic" evidence="12">
        <location>
            <begin position="157"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="7"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>L-homoserine</name>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR036497-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR036497-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AIF83913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="338" mass="36077" checksum="9E978FB677C20B1C" modified="2014-10-29" version="1">MRVILVGFGVVGQSFAKLLLSRSADLYSQHGVKPRIVACVDNRGSAVSPAGLNLERLLAAKKAKGTVGAYDKKSATKFNPLQVIENVEAEVVIECTPTDLSTGEPGTSHIISAMRTGKNVISINKGPLALAFPSLIELANYNGVMFRFSGTVGGGTPILEFAKRCLKGDRITSFQGILNGTTNYILSKMEEGLTYQSALLDAKEKGYAEAKPELDTDGYDAAAKLVIMANWIMGMKVTMKDVARTGISEVSVADVEKAQSRANAIKLIAACDSRRLEVKPTEVSKKDPICVNGTLNAVTFSSEHSGSQTIIGRGAGGMETASAVLRDLIEIRDTIFER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MS75</accession>
    <name>A0A075MS75_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">succinate dehydrogenase</fullName>
            <ecNumber evidence="4">1.3.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">NTE_01594</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SR1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="4"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700388.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MS75"/>
    <dbReference type="STRING" id="1459636.NTE_01594"/>
    <dbReference type="GeneID" id="41597374"/>
    <dbReference type="KEGG" id="nev:NTE_01594"/>
    <dbReference type="eggNOG" id="arCOG00571">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014312_6_2_2"/>
    <dbReference type="OrthoDB" id="23539at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.700.10:FF:000003">
        <property type="entry name" value="Fumarate reductase flavoprotein subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.100">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.80.40">
        <property type="entry name" value="succinate dehydrogenase protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003952">
        <property type="entry name" value="FRD_SDH_FAD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014006">
        <property type="entry name" value="Succ_Dhase_FrdA_Gneg"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004724">
        <property type="entry name" value="PRK06069.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01812">
        <property type="entry name" value="sdhA_frdA_Gneg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE 2 FLAVOPROTEIN SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632:SF51">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000171">
        <property type="entry name" value="SDHA_APRA_LASPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00504">
        <property type="entry name" value="FRD_SDH_FAD_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="14" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="12">
        <location>
            <begin position="8"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal" evidence="13">
        <location>
            <begin position="446"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000171-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AIF83657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="570" mass="63282" checksum="7EBE37536671AC25" modified="2014-10-29" version="1">MVDTISHDVLIIGSGLAGLRAAIAAAATDKNLSIGVISKVQVMRSHSVSAEGGTAAVLYEEEGDNQESHIYDTVKGSDFLADQDVAERLVRNMPFEVYQLDHWGMPWSRRKDGRIAQRKFGGYSFPRATFAQDKVGFYEMQTLYDTCLKHGNIHFYNEWFCTSILRDSAFQGITAIEIKTGNFTIFKAPAGIICTGGAGRIYSFSTYAFSSTPDGIDMAFRAGLAMKDMEFVQFHPTGIMPSGILITEGARGEGGYLINSKGERFMTKYAPGKMELAPRDVVSRSMIREIQEGRGFKHETGFDCLKLDLTHLGDERIKEVLAGIREIGIKFSGVDIIDEPIEVRPVCHYMMGGIHANIDGATELPGLWTAGEAACNSTHGANRLGANSTSECIVWGRITGELAAQYASARKSKSIEISQAQVADEEKRIYDGLFRGSGSVNPYQVRKELTDTMDDKAYVFRNEEGLSSALKKVRELKAAMWKHVDDKAKEYNTNFVNVMETDSMLRTAEVVLVGALNRKESRGAHARTDYPNRDDTNFLNHTLAYHTPDGPRMAWHPVTFTRYAPVERKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MS81</accession>
    <name>A0A075MS81_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Membrane-associated sensor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_02364</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700996.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MS81"/>
    <dbReference type="STRING" id="1459636.NTE_02364"/>
    <dbReference type="GeneID" id="41598080"/>
    <dbReference type="KEGG" id="nev:NTE_02364"/>
    <dbReference type="HOGENOM" id="CLU_1032900_0_0_2"/>
    <dbReference type="OrthoDB" id="374460at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033425">
        <property type="entry name" value="MASE3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17159">
        <property type="entry name" value="MASE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Membrane-associated sensor" evidence="2">
        <location>
            <begin position="50"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF84416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="269" mass="29579" checksum="263499A65C236AC5" modified="2014-10-29" version="1">MLSSHQTQSRKWQAFVFALAIAGSSAGILAATVIAGDFESRQASSVLFLASGAMGLIVFFQEMYAFYVTNSRRILWMSAGFFTLGIGMIGNAITTGGSLDAALDSYVSASELFRGTSEFAAAIFILLGTLRSDKSIRENMEFKAYILVAVIMVTTASIIIYISTIQESLSVPLYSSQYGWSPFSLYIELHVLIFFAVTCTVYVSIRKKNNNSQILFWFIIGFVLLTFSELSFTIDKVLDLGASSSLIWMGRLFLLAGFATFVLGLNRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MS89</accession>
    <name>A0A075MS89_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase, aryl-alcohol dehydrogenase like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MS89"/>
    <dbReference type="STRING" id="1459636.NTE_01970"/>
    <dbReference type="KEGG" id="nev:NTE_01970"/>
    <dbReference type="eggNOG" id="arCOG01623">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054485_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd19099">
        <property type="entry name" value="AKR_unchar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053135">
        <property type="entry name" value="AKR2_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43312">
        <property type="entry name" value="D-THREO-ALDOSE 1-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43312:SF1">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="1">
        <location>
            <begin position="67"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="405" mass="44886" checksum="605C4612C7E372BA" modified="2014-10-29" version="1">MLPSGEHTFIIAAGDRKCVSSSAADFKVIEGHATPEGTKKYASYGVSKKGLPATHFREFDGLYLSSIGMGTYLGDLTKEDDIAVENAVYESVMSGAINVIDTAINYRAMKSEKSIGRALLRLASEGKISRDQIFISTKNGYITNDGDFPNVDVMEYMHRMYIANDVMTADDISSGYNVMNPNYLAKCIEKSLANMHLSTIDLVYIHNAFESWHEDVDRKTFAEMLAKVFELYEKYRKAGKLRYYGMATWTCFRVPKGEKEHFSLEDAVKIAREVGGDSHGFKFIQLPYNLAYSEALLLKNQPAGTDMITILEAAGKLGIGVFTSAPLFQGRLLRAQIPDYVGVGDNNKVAKLVQVLRSSPSVVAPLLGQKSPEHIRENIQVASIPPLTREEFAQAIDTLMNRPMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSJ6</accession>
    <name>A0A075MSJ6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">5-amino-6-(D-ribitylamino)uracil--L-tyrosine 4-hydroxyphenyl transferase</fullName>
            <ecNumber evidence="2">2.5.1.147</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">NTE_02502</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>5-amino-6-(D-ribitylamino)uracil + L-tyrosine + S-adenosyl-L-methionine = 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + 2-iminoacetate + 5'-deoxyadenosine + L-methionine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:55200"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:77846"/>
            <dbReference type="ChEBI" id="CHEBI:85936"/>
            <dbReference type="EC" id="2.5.1.147"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="10">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; coenzyme F0 biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.147" evidence="2"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701105.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSJ6"/>
    <dbReference type="STRING" id="1459636.NTE_02502"/>
    <dbReference type="GeneID" id="41598206"/>
    <dbReference type="KEGG" id="nev:NTE_02502"/>
    <dbReference type="eggNOG" id="arCOG00656">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040406_1_1_2"/>
    <dbReference type="OrthoDB" id="8186at2157"/>
    <dbReference type="UniPathway" id="UPA00072"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141093">
        <property type="term" value="F:5-amino-6-(D-ribitylamino)uracil--L-tyrosine 4-hydroxyphenyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044689">
        <property type="term" value="F:7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01612">
        <property type="entry name" value="FO_synth_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045567">
        <property type="entry name" value="CofH/MnqC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019940">
        <property type="entry name" value="CofH_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034405">
        <property type="entry name" value="F420"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020050">
        <property type="entry name" value="FO_synthase_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00423">
        <property type="entry name" value="CofH family radical SAM protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03551">
        <property type="entry name" value="F420_cofH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005609">
        <property type="entry name" value="PRK07360.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43076">
        <property type="entry name" value="FO SYNTHASE (COFH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43076:SF1">
        <property type="entry name" value="LIPOYL SYNTHASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19288">
        <property type="entry name" value="CofH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004762">
        <property type="entry name" value="CHP00423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01388">
        <property type="entry name" value="7_8-didemethyl-8-hydroxy-5-dea"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01064">
        <property type="entry name" value="F420__menaquinone_cofactor_bio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01389">
        <property type="entry name" value="menaquinone_synthsis_involved"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 10" id="KW-0408">Iron</keyword>
    <keyword evidence="8 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="12">
        <location>
            <begin position="62"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>(3R)-3-methyl-D-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:64642"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>(3R)-3-methyl-D-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:64642"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR004762-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR004762-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIF84551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="421" mass="46599" checksum="D2FA81B3EB043975" modified="2014-10-29" version="1">MALESVLKNADPIVASALDRALSGKDITVDEAIALFDCTGLEMNLLVTVADELRRRTVGDIVTYVVNRNVNFTNVCIKQCGFCAFSRDFREEEGYFLPNEEIVRRAKEAASLGATEVCIQAGLPPKMDGHLYVDICKAVKKDLPDMHIHAFSPEEVLYGAVRSGTQTLDYLKMLKEAGVGSLPGTAAEILDQSLRDVISPGRIKVDDWVSIIKQAHSLGIATTSTIMYGHIETSRHKAEHIALLREIQKETHGFTEFVPLSFVHTEAPMYSHHTVPGIRAGADGNEVVKMHAVARIMLNNHIPNIQVSWVKEGARMSQLLLAAGANDFGGTLINESISTAAGAQHGQLMRPREIRQLIRSSGRIPAQRSTTYKLLKTFRNESDETESALDNVNSSQFGSYHQLVKLDKFRYKDAKKQQQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSL3</accession>
    <name>A0A075MSL3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02517</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701119.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSL3"/>
    <dbReference type="STRING" id="1459636.NTE_02517"/>
    <dbReference type="GeneID" id="41598221"/>
    <dbReference type="KEGG" id="nev:NTE_02517"/>
    <dbReference type="HOGENOM" id="CLU_1870627_0_0_2"/>
    <dbReference type="OrthoDB" id="374065at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="136" mass="14602" checksum="226A6732C3046393" modified="2014-10-29" version="1">MDSSNLEKVVLDLQKRVASLEQAVYGSSGGSSNNGGAKAAMRGLEQRIVEKVDDIGTQDLILVALLQNPKQSKARIRQVLNDWGKAYGSWFEGGNFSGRLVKAGLVKKDGSSDDGEELFSLTKKGEMEAGNLVSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSM2</accession>
    <name>A0A075MSM2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02098</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700780.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSM2"/>
    <dbReference type="GeneID" id="41597831"/>
    <dbReference type="KEGG" id="nev:NTE_02098"/>
    <dbReference type="HOGENOM" id="CLU_920106_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="302" mass="32459" checksum="FFCC46E625C0A5EF" modified="2014-10-29" version="1">MAIDQSTLIQINATIIAGAIVLLTINAAIDITHSAFNRYAVTLTALAIIIPFAGSSIRAFDEKELDAAKKLTQGGFGVLIIGLAALAFLVLFDDVRGVTAPVKVDSNMTSIVDSGQPQIAIDPLTWATVGLAVGTFVLAIVAFFSLRESKKLRIEAQLPNFAVEPAQQFGDRMLRLNLVNNGQGASGIMARCNWGKDLYTLTNSKSTYILSLAKGGYAGLDVPIDQIKLNGEILKIMLECKDSSGQDYTAEVLLDFNKIQGSGITIAYQNNYFLTLYDAIKGVSDKLYNINSAIDKVASKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSQ1</accession>
    <name>A0A075MSQ1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5615 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700793.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSQ1"/>
    <dbReference type="STRING" id="1459636.NTE_02115"/>
    <dbReference type="GeneID" id="41597844"/>
    <dbReference type="KEGG" id="nev:NTE_02115"/>
    <dbReference type="HOGENOM" id="CLU_1393525_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041049">
        <property type="entry name" value="DUF5615"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18480">
        <property type="entry name" value="DUF5615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5615" evidence="1">
        <location>
            <begin position="10"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="195" mass="22408" checksum="DE043A049665E4AB" modified="2014-10-29" version="1">MIKVETPCKRLLLDECVTRRLVLRLPKSANIDIEHSLDVAGLGMAASDDDILAYAIKTNRTIVTIDRKFIRECLIKKVPVATYDKGTARFHGSGESLWLGKHYEYRKVSVRLIEAEKKTLMGNVRNCVYGSRRHIRKHIRPVILLYRKLKAMTPQGRRSKCKVCGIQHRSPQRLQNHLRNTKCGRTNTARKSKTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MST5</accession>
    <name>A0A075MST5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02593</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MST5"/>
    <dbReference type="KEGG" id="nev:NTE_02593"/>
    <dbReference type="HOGENOM" id="CLU_2712615_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="72" mass="7834" checksum="41F16837C97F06B6" modified="2014-10-29" version="1">MSSVEIGRQSGFCSHVGLLALLSILGRHSDKEASNTFYYLSTGASSAGDLLFHIAIPIATIHKSKMRINKWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSW2</accession>
    <name>A0A075MSW2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative nucleic-acid-binding protein containing a Zn-ribbon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01816</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700572.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSW2"/>
    <dbReference type="STRING" id="1459636.NTE_01816"/>
    <dbReference type="GeneID" id="41597581"/>
    <dbReference type="KEGG" id="nev:NTE_01816"/>
    <dbReference type="eggNOG" id="arCOG01289">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_168008_0_0_2"/>
    <dbReference type="OrthoDB" id="9573at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.30.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022002">
        <property type="entry name" value="ChsH2_Znr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052513">
        <property type="entry name" value="Thioester_dehydratase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34075">
        <property type="entry name" value="BLR3430 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34075:SF5">
        <property type="entry name" value="BLR3430 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12172">
        <property type="entry name" value="zf-ChsH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ChsH2 rubredoxin-like zinc ribbon" evidence="1">
        <location>
            <begin position="11"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="117" mass="12655" checksum="C1F9D95650D62D61" modified="2014-10-29" version="1">MASPSLFIEYLKKGEFVVPVCTSCGQKAWPPSPTCPKCFGRTALKKVGKTGTLAEFATSHVRGHEGVFGIVEMDGFRLVGSLDGDKKLRKGVKVKMDRCGVNAEGAPFYHFTLTTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSZ7</accession>
    <name>A0A075MSZ7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">4Fe-4S dicluster domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NTE_00377</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699429.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSZ7"/>
    <dbReference type="STRING" id="1459636.NTE_00377"/>
    <dbReference type="GeneID" id="41596264"/>
    <dbReference type="KEGG" id="nev:NTE_00377"/>
    <dbReference type="eggNOG" id="arCOG04548">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1507315_0_0_2"/>
    <dbReference type="OrthoDB" id="23833at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050572">
        <property type="entry name" value="Fe-S_Ferredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43687">
        <property type="entry name" value="ADENYLYLSULFATE REDUCTASE, BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43687:SF6">
        <property type="entry name" value="L-ASPARTATE SEMIALDEHYDE SULFURTRANSFERASE IRON-SULFUR SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13237">
        <property type="entry name" value="Fer4_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="9">
        <location>
            <begin position="62"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="9">
        <location>
            <begin position="124"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="109"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIF82459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="180" mass="19888" checksum="EA90B747724F1DCF" modified="2014-10-29" version="1">MPIDPEFPKNHQVIGKHKLADGEHFHFVWGPGKVAEAAENEEVKKAYETRGEQIVPLGVHGTMVAIDWDSCIADGACIEACPVQVYEWYRTDHQDVPAIEMQNATSAGKGEDHSKDGRMDFTDKSDPIREHDCIWCMACVSVCPPQAVKVDQSNLEFHEKAAGTFNEELAKGSAPPPHAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTD3</accession>
    <name>A0A075MTD3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MEDS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701035.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTD3"/>
    <dbReference type="GeneID" id="41598125"/>
    <dbReference type="KEGG" id="nev:NTE_02415"/>
    <dbReference type="HOGENOM" id="CLU_830548_0_0_2"/>
    <dbReference type="OrthoDB" id="375020at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025847">
        <property type="entry name" value="MEDS_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14417">
        <property type="entry name" value="MEDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MEDS" evidence="1">
        <location>
            <begin position="55"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="334" mass="37497" checksum="6F115F6EDCBE1E4D" modified="2014-10-29" version="1">MRNYPITVSPKSKPIQSIKKIVAEHLDAENARLRFNQVNHFIDNVVGFDTSFSCRHILLVYEEIESARQIEMRYLKSRLQKGETCMCLAHGDNSTEEGHDSESNMMRAEMTDSGIDIDRLEKTGQLAIMTIPDSGSLKTQDCNHPKSVNATYLELVGKMFGGKKPPFGGFGIAASERDLRKPEGLALQLQLERLGKKGFENFVGTWICPYAVDDLIESLDKEWMRELLLCHDAVICVRRDFSAIALNLVHSNSISFSSRTVRAALFKLEPSLGRAAIETILQDMEIYGMPLDDDHATHTIADIELAMRRIFGGEGGALIMERLRRILIPSPVDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTK1</accession>
    <name>A0A075MTK1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Phosphoglycerate mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NTE_02050</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate</text>
            <dbReference type="Rhea" id="RHEA:15901"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="5.4.2.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148702113.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTK1"/>
    <dbReference type="STRING" id="1459636.NTE_02050"/>
    <dbReference type="GeneID" id="41597790"/>
    <dbReference type="KEGG" id="nev:NTE_02050"/>
    <dbReference type="eggNOG" id="arCOG01696">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034906_2_0_2"/>
    <dbReference type="OrthoDB" id="52918at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004619">
        <property type="term" value="F:phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16011">
        <property type="entry name" value="iPGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2130">
        <property type="entry name" value="Metalloenzyme domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006124">
        <property type="entry name" value="Metalloenzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004456">
        <property type="entry name" value="Pglycerate_mutase_ApgM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042253">
        <property type="entry name" value="Pglycerate_mutase_ApgM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00306">
        <property type="entry name" value="apgM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31209">
        <property type="entry name" value="COFACTOR-INDEPENDENT PHOSPHOGLYCERATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31209:SF0">
        <property type="entry name" value="METALLOENZYME DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01676">
        <property type="entry name" value="Metalloenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10143">
        <property type="entry name" value="PhosphMutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006392">
        <property type="entry name" value="IPGAM_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metalloenzyme" evidence="6">
        <location>
            <begin position="7"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF84107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="430" mass="46463" checksum="507DE8B6EE245ECD" modified="2014-10-29" version="1">MRKDGVKIVYVLLDGIGDLPHPALNDLTPLEAAYTPNLDALARNGAMGRVITVGKGIAPQSDIAVFNMLGYSFRDGGYVGRGVIESIGCNIDFQDGDLALRGNFATVDDKNNKITDRRAGRVISKEEATAVCKTLENSIKFSDKDASIALVPTVAHRVVIRIHHSKMKLSDKITNTDPAYDKVEGMGVAKATSDDIYVQEAKAQDDSKEARMAAMLVNEFTEQTIKILRDHPVNVARKAAGRNPMNCILARDSGNRFPQVQPINKKYGISIGCIVEMPVEVGISKVLGMKMYEAGSLDDYELKARVAAKSLKTVDAVYVHLKGPDEFGHDGDAKGKKRNLEEIDKRFFGVLAKELAGVKNPVIVVSGDHSTPCIKKAHSDDPVPLLVSGNGVRQDGSARFTEGYGRKGSLGLLMGADVVSTALKLATDRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTN3</accession>
    <name>A0A075MTN3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase, FkbM family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700762.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTN3"/>
    <dbReference type="STRING" id="1459636.NTE_02076"/>
    <dbReference type="GeneID" id="41597810"/>
    <dbReference type="KEGG" id="nev:NTE_02076"/>
    <dbReference type="eggNOG" id="arCOG01402">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074577_1_1_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006342">
        <property type="entry name" value="FkbM_mtfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052514">
        <property type="entry name" value="SAM-dependent_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01444">
        <property type="entry name" value="fkbM_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34203">
        <property type="entry name" value="METHYLTRANSFERASE, FKBM FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34203:SF15">
        <property type="entry name" value="SLL1173 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05050">
        <property type="entry name" value="Methyltransf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase FkbM" evidence="1">
        <location>
            <begin position="76"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="262" mass="29712" checksum="D8267B2CD31139AF" modified="2014-10-29" version="1">MGIVVRFRPLAGKVLRSIKGPKFKPPARDGDKYDIQGSWMYVDDKDSMQLTQHGIYGPEQTSLIKRLVKGDYTCLDIGANIGYFTLIMARQARQVYAFEPEPRNFEILQKNVALNNMQDIVKLYDFAVAETSDRATLHLCEMNRGMHRLYQSHWCNDGTVEVRTARIDDLVSQADFVKMDIEGAELGALKGMKKLLERGTVLWMEFHPPSIVEYGASPRDVYDYMESLGYSVEIPGLGKVSFDELEKISNEKAGTNVLCRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTQ5</accession>
    <name>A0A075MTQ5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00583</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699589.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTQ5"/>
    <dbReference type="STRING" id="1459636.NTE_00583"/>
    <dbReference type="GeneID" id="41596447"/>
    <dbReference type="KEGG" id="nev:NTE_00583"/>
    <dbReference type="HOGENOM" id="CLU_851529_0_0_2"/>
    <dbReference type="OrthoDB" id="376951at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="326" mass="37842" checksum="20669EB6A4A30704" modified="2014-10-29" version="1">MIEDESKNNNSNSVAIDKTRRTGIMSAVVVSLAALLIFATVQSSPHGASAAVAGEQAAKIINNDNAAFDKSDSSVAAAKQQRQHQQQYWQEFLKLEKESWHYNYSKVEKQNVKAYQKWYCADLRLHGYKDFTHACDRSAYPKDAMWQHEQLRDEMLWNKANHQPHHEIKKTDEQLKYLQKRTEMRDSMTQHGKPGDMTWRHYLSLEKQAWHYDYAKTEQQNLKTFHKWWSRGGEKESDKAHKMWFSEQYGREILWDKATTAATTTNKGVSDNGSNKGYMQSWFEEAYRQHKAEIAKNKCVNPWERTPSNAAPLWSACLDAKGSSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTW1</accession>
    <name>A0A075MTW1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTW1"/>
    <dbReference type="STRING" id="1459636.NTE_00629"/>
    <dbReference type="KEGG" id="nev:NTE_00629"/>
    <dbReference type="eggNOG" id="arCOG08774">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1648360_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="195" mass="21026" checksum="E4F9F65F85B05A44" modified="2014-10-29" version="1">MLFLVCFYLELLHGVTALASKKGIVITAIIAAGIIGTSVLIWLLPQQGTPTGVNITDEKGAEADAANLPADNLSFVYTQHNFATTEVENSFDKWSKGEVAANDMNAAISTARSNLDALKKRVDTPGVPQQWQESYGLYSQALGKFGSYLDEMKRLVDSNDKNAADHATLDSIKTEMNDLVDRSIKAFPTTAAPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTX9</accession>
    <name>A0A075MTX9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NADH dehydrogenase subunit D</fullName>
            <ecNumber evidence="9">1.6.5.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NTE_02556</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the complex I 49 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.3" evidence="9"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTX9"/>
    <dbReference type="STRING" id="1459636.NTE_02556"/>
    <dbReference type="KEGG" id="nev:NTE_02556"/>
    <dbReference type="eggNOG" id="arCOG01548">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015134_1_2_2"/>
    <dbReference type="OrthoDB" id="43567at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="entry name" value="Cytochrome-c3 Hydrogenase, chain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001135">
        <property type="entry name" value="NADH_Q_OxRdtase_suD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014029">
        <property type="entry name" value="NADH_UbQ_OxRdtase_49kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022885">
        <property type="entry name" value="NDH1_su_D/H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993:SF10">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 49 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00346">
        <property type="entry name" value="Complex1_49kDa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="HydB/Nqo4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00535">
        <property type="entry name" value="COMPLEX1_49K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-1278">Translocase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="NADH-quinone oxidoreductase subunit D" evidence="8">
        <location>
            <begin position="141"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="NADH-quinone oxidoreductase subunit D" evidence="8">
        <location>
            <begin position="311"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF84603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="386" mass="44352" checksum="5821AEE18BDAB11A" modified="2014-10-29" version="1">MASLEEKIEETRKLGLQVVKETEDDRLMTLSIGPQHPGSGHFRFTVKVDGDYIVYCDPDPGYVHRGEEKMCEYRNVIQNIPHLERPVIHDSTNITYSYSLAVEELMGIEVPRRGQFIRALASEMNRQVYTLYWLAIYGIFLGHSTMFMWPAGDRELFIDLLERLTGARVTHAYNIPGGVRNDMPDNFKAKCLEHINYFEKRLKEYEDIFYNMPLFRQRTEGVGVLSKEDAIKLGVTGSVLRASGVPYDIRKVEPYDIYNEIDFKVQYMKTGDSFARSYVPFLDMKESCNIMRQLLDKMPSSGDVRTKLQPNPKGPPGEAYRRVESGRGALGYYIVSDGTPKPYRVKISVGSFRNMLALPFLLVGNKLADMPSIYWSLNYWPVEADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MU15</accession>
    <name>A0A075MU15_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_02163</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700830.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MU15"/>
    <dbReference type="STRING" id="1459636.NTE_02163"/>
    <dbReference type="GeneID" id="41597887"/>
    <dbReference type="KEGG" id="nev:NTE_02163"/>
    <dbReference type="eggNOG" id="arCOG08635">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1393619_0_0_2"/>
    <dbReference type="OrthoDB" id="11234at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="116"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF84217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="201" mass="22127" checksum="C6E78753E991C437" modified="2014-10-29" version="1">MSGELAVIAGSSVAGAISAALIDRAAAAARAKKPRNDKQQPQEEKRTASNAKAELASLAFEKTLAAEAITRVYEAAQDGRIDHLERDRLLVKYKHDLDALNERIATLKPVAEYAELADMRNNLASLLENKISALDQKLAEMSKAGAAPVVIERVQVMPIPEKVRDDSEKKQFKAEEKSIEQLQKEIVQALTRLEQVELDKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MU23</accession>
    <name>A0A075MU23_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter, substrate-binding protein, aliphatic sulfonates family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NTE_03132</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the bacterial solute-binding protein SsuA/TauA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MU23"/>
    <dbReference type="STRING" id="1459636.NTE_03132"/>
    <dbReference type="KEGG" id="nev:NTE_03132"/>
    <dbReference type="eggNOG" id="arCOG01803">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028871_10_0_2"/>
    <dbReference type="OrthoDB" id="10037at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13553">
        <property type="entry name" value="PBP2_NrtA_CpmA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010067">
        <property type="entry name" value="ABC_SsuA_sub-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044527">
        <property type="entry name" value="NrtA/CpmA_ABC-bd_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01728">
        <property type="entry name" value="SsuA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30024">
        <property type="entry name" value="ALIPHATIC SULFONATES-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30024:SF47">
        <property type="entry name" value="TAURINE-BINDING PERIPLASMIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13379">
        <property type="entry name" value="NMT1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF85166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="365" mass="39192" checksum="0F6BBF4767D66BE9" modified="2014-10-29" version="1">MNNNKIKFGIAAAIIVAVIATSVPLFAGSQAANSDAASSSQAAAPQQQQQESKVVRIGYFPNINHAQAVIGLGRGDFQKALGSNVEVKTQVFNAGPSAIEALFAKQVDITYIGPNPAINGYVKSDGQGLRIVSGAASGGAVFVVRNDSGIQTPADFAGKKFASPQLGNTQDVALRKYLLENGYRTKENGGNVEVIPAANADILALFLKKEIDGAWVPEPWGAKLVKEAGGRIFLDEQDRWPGGQFVTAHIIVSTDYLKNNPDVVKKVIAANVDETKWINDHPDEALKVYNEELKKLTGKTIPEDEYKAGTSRLTLTYDPVEDSLFKSASDAHDIGFLKQKPDLSGIYDLTLLNEVLKEKGLPQIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MU58</accession>
    <name>A0A075MU58_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-type dipeptide/oligopeptide/nickel transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NTE_00771</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699741.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MU58"/>
    <dbReference type="STRING" id="1459636.NTE_00771"/>
    <dbReference type="GeneID" id="41596622"/>
    <dbReference type="KEGG" id="nev:NTE_00771"/>
    <dbReference type="eggNOG" id="arCOG00749">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028518_10_0_2"/>
    <dbReference type="OrthoDB" id="312811at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="entry name" value="MetI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43839">
        <property type="entry name" value="OPPC IN A BINDING PROTEIN-DEPENDENT TRANSPORT SYSTEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43839:SF1">
        <property type="entry name" value="OPPC IN A BINDING PROTEIN-DEPENDENT TRANSPORT SYSTEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="MetI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="311"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="386"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="438"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="269"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF82849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="477" mass="51769" checksum="9A22508C605851E5" modified="2014-10-29" version="1">MSSRSPAAAAAAISRSQILLEFRHSKSGLAGIGILLALILMTIYSVVAIPLDSYRQWNNPDFWIDLPKSAAPAWTNIGFGPKVPEHFVLHARNAEVSSALGEGGSRTVTYSYTVNFNYDSYPSDFMLLYSAKYGSTQPALQADVLRPDGKEFRIYFAPLPPASQSLGSADNEFSGRVFSTDSGIAENLRSYTGDFAYRQDPSRPQVMIFADSQKNQVLKGTYVIRETFYLFGQDDAVTDSGVILGGKVYGLMGTDELRRDLATGILWAAPVALFIGLTVSVASILIGLIYGVVAGYKGKRTDEGLMRINDIFYSLPTLPLLVILSVTIGRSIFLITGFLVIFGWVGMAKISRSLALQLKNLQYVEAAKLMGQSDTRIIFRHIIPQLLPLTFASIAIAVPTAILGEAALSFLGLGDPSIPTWGQILHDANSAGAAVRGLWWWIVPPGLMIALTGLAFALIGNALDSIVNPRAKRMMQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUF7</accession>
    <name>A0A075MUF7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Anhydromevalonate phosphate decarboxylase</fullName>
            <ecNumber evidence="6">4.1.1.126</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NTE_02706</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the conversion of trans-anhydromevalonate 5-phosphate (tAHMP) into isopentenyl phosphate. Involved in the archaeal mevalonate (MVA) pathway, which provides fundamental precursors for isoprenoid biosynthesis, such as isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(2E)-3-methyl-5-phosphooxypent-2-enoate + H(+) = isopentenyl phosphate + CO2</text>
            <dbReference type="Rhea" id="RHEA:78971"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:65078"/>
            <dbReference type="ChEBI" id="CHEBI:229665"/>
            <dbReference type="EC" id="4.1.1.126"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:78972"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>prenylated FMN</name>
            <dbReference type="ChEBI" id="CHEBI:87746"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UbiD family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.126" evidence="6"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701264.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUF7"/>
    <dbReference type="STRING" id="1459636.NTE_02706"/>
    <dbReference type="GeneID" id="41598395"/>
    <dbReference type="KEGG" id="nev:NTE_02706"/>
    <dbReference type="eggNOG" id="arCOG01671">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023348_5_1_2"/>
    <dbReference type="OrthoDB" id="8480at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1670.10:FF:000003">
        <property type="entry name" value="Phenolic acid decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1670.10">
        <property type="entry name" value="UbiD C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002830">
        <property type="entry name" value="UbiD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049381">
        <property type="entry name" value="UbiD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049383">
        <property type="entry name" value="UbiD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048304">
        <property type="entry name" value="UbiD_Rift_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00148">
        <property type="entry name" value="UbiD family decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30108">
        <property type="entry name" value="3-OCTAPRENYL-4-HYDROXYBENZOATE CARBOXY-LYASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30108:SF21">
        <property type="entry name" value="4-HYDROXYBENZOATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01977">
        <property type="entry name" value="UbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20696">
        <property type="entry name" value="UbiD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20695">
        <property type="entry name" value="UbiD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143968">
        <property type="entry name" value="UbiD C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-octaprenyl-4-hydroxybenzoate carboxy-lyase-like N-terminal" evidence="10">
        <location>
            <begin position="17"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="3-octaprenyl-4-hydroxybenzoate carboxy-lyase-like Rift-related" evidence="9">
        <location>
            <begin position="123"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="3-octaprenyl-4-hydroxybenzoate carboxy-lyase-like C-terminal" evidence="11">
        <location>
            <begin position="314"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF20695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIF84748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="470" mass="51686" checksum="316D673733CA87ED" modified="2014-10-29" version="1">MANSSNNNNGGDLRSYLELLEKEGELVRIKKPVSTKFELAAVVSKFDSKQAVLFEKVKEGGKISTVASNVCGTPGRFYMATSSAKSAPKGIAETKKAIRSRVSEALAGMSAPLKTQEGKALFEQNSSRNLNDLPIVTHFEKDAGAFATASVVFAKDGERRNQNSSTHRLLRLDEKHMAIRMVEGRHLHKCYTYAKEHGEDLKVAIAVGVHPAVSIAAAYQAAYGVDEMMIANALLEGKLKLAKTGYSQLYVPNHSEIIIEGRILKDRVQEEWMVEMLRTYDFKRKQPVFELEKLSFRDGAIYHDILPGYAEHRLLMGLPVEAKMYDYVKSVVPTTQAVHLTDGGSNWLSAVIQIKKRLEGEPKNAIMAAFAAHPSLKMATVVDDDIDPTDAVAVEYAVATRCQADRGFVVIPNAKGSSLDPSSDQQNLLTTKVGIDATATILKPKERFEIARIPGEDEINVSDYASNKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUH8</accession>
    <name>A0A075MUH8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Universal stress protein UspA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_00893</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699832.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUH8"/>
    <dbReference type="STRING" id="1459636.NTE_00893"/>
    <dbReference type="GeneID" id="41596733"/>
    <dbReference type="KEGG" id="nev:NTE_00893"/>
    <dbReference type="eggNOG" id="arCOG02053">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049301_16_2_2"/>
    <dbReference type="OrthoDB" id="105697at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00293">
        <property type="entry name" value="USP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46268">
        <property type="entry name" value="STRESS RESPONSE PROTEIN NHAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46268:SF6">
        <property type="entry name" value="UNIVERSAL STRESS PROTEIN UP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UspA" evidence="2">
        <location>
            <begin position="6"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF82969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="144" mass="15525" checksum="778BDB2C9FB865CE" modified="2014-10-29" version="1">MRKEVYSKVLVATDGSECARKALESAIKIVKASNGSLTIIHVLQIPRTVGFGKKLTPEILLFYRRDAKAFLAEQQREVELHGIKADILLREGSPAKAILNAAKAMNADLIVMGSRGLGGVKELFLGSVSNAVVHSSKISVLITK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUQ2</accession>
    <name>A0A075MUQ2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02828</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUQ2"/>
    <dbReference type="STRING" id="1459636.NTE_02828"/>
    <dbReference type="KEGG" id="nev:NTE_02828"/>
    <dbReference type="HOGENOM" id="CLU_1801613_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="143" mass="15522" checksum="76F179874F7DC77C" modified="2014-10-29" version="1">MHEGFAEPLVIRIVDSEGNLLNGARVTAAPKTGPLMPSSGFSPAVTFSNLKNATTYVVSVPTTFVGSNFISISNSHTSSSNDDDGNSSSGDSSSGIYHFDHWQGIDGYYHYSRNTYNIEVTVYSSPTFFANYEITLIAVYNKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUS4</accession>
    <name>A0A075MUS4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Activator of Hsp90 ATPase homologue 1/2-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_00979</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699897.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUS4"/>
    <dbReference type="STRING" id="1459636.NTE_00979"/>
    <dbReference type="GeneID" id="41596808"/>
    <dbReference type="KEGG" id="nev:NTE_00979"/>
    <dbReference type="HOGENOM" id="CLU_109811_1_0_2"/>
    <dbReference type="OrthoDB" id="8815at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd08901">
        <property type="entry name" value="SRPBCC_CalC_Aha1-like_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="ASHA1/2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Activator of Hsp90 ATPase homologue 1/2-like C-terminal" evidence="2">
        <location>
            <begin position="14"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF83054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="146" mass="16707" checksum="DFCA603A70501685" modified="2014-10-29" version="1">MELRFDVYAKIRKPVAEVFDAVYNPKKLSGYFATGGASGPLDEGKTVTWDFHDFPGAFPVHVKQVIMNQKIVFEWANNEGTNCRVEMNFEALDKHSTLVKISESGWKKEDQKSLDASYGNCMGWTQMLCCLKVYVEDGKNLREFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUS7</accession>
    <name>A0A075MUS7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Arabinose efflux permease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NTE_02922</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUS7"/>
    <dbReference type="STRING" id="1459636.NTE_02922"/>
    <dbReference type="KEGG" id="nev:NTE_02922"/>
    <dbReference type="eggNOG" id="arCOG00130">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_718874_0_0_2"/>
    <dbReference type="OrthoDB" id="117970at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050171">
        <property type="entry name" value="MFS_Transporters"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23517:SF13">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23517">
        <property type="entry name" value="RESISTANCE PROTEIN MDTM, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="291"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="326"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="3"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF84960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="382" mass="40589" checksum="3122926DA19C3106" modified="2014-10-29" version="1">MKPILFVAACAAIVGIAYGMHSPIVPVFAKEELGANFSEVGVIGLANYLPYMVVPLFGGMLLDRTNKAYLLILGVSLNAFAIFMLSEVTSVAGATAFRGLSGIAHAFFWPSAEAIISTTAPSDKRVKWIALFTAAWVGGFMTGPLIGKVVLEHFDYRVLFELSALAISLALVPSFFLLRHGRPVQVERHRLLRLGDLKHEVASMPTVSAVVLYYAVTFGVLIAIYPAYMKAASITDQNIELLFFVFGMARFATLPFVRLMAGRGRAALAAAVAVMAASMAISFAFASVWSFAIALVLAGVATSIFYPVTFNFVTKNAPVEKMGTKLGIYEALFGAGWTVGPVGVGLSSDAFGPASPYLAFSVIGAALAGAIMVTIRKNNNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUU4</accession>
    <name>A0A075MUU4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02939</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701456.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUU4"/>
    <dbReference type="STRING" id="1459636.NTE_02939"/>
    <dbReference type="GeneID" id="41598617"/>
    <dbReference type="KEGG" id="nev:NTE_02939"/>
    <dbReference type="HOGENOM" id="CLU_2191111_0_0_2"/>
    <dbReference type="OrthoDB" id="374128at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="115" mass="12731" checksum="6880E1DD18417E8D" modified="2014-10-29" version="1">MENDRSVILRRAFDKELMSLGSSIYQTIMWHMDGRGVFSNPRTVDIDSLYSNLREIVGPHADMILDMTWADLEKNHGAKDLEKSKKSFDKISRWLGAEGGGVAAAAEGKEGGGMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUV9</accession>
    <name>A0A075MUV9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uroporphyrinogen-III synthase</fullName>
            <ecNumber evidence="2">2.1.1.107</ecNumber>
            <ecNumber evidence="2">4.2.1.75</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.107" evidence="2"/>
    <dbReference type="EC" id="4.2.1.75" evidence="2"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699918.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUV9"/>
    <dbReference type="STRING" id="1459636.NTE_01010"/>
    <dbReference type="GeneID" id="41596834"/>
    <dbReference type="KEGG" id="nev:NTE_01010"/>
    <dbReference type="eggNOG" id="arCOG02048">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011276_9_5_2"/>
    <dbReference type="OrthoDB" id="15395at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004851">
        <property type="term" value="F:uroporphyrin-III C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004852">
        <property type="term" value="F:uroporphyrinogen-III synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006780">
        <property type="term" value="P:uroporphyrinogen III biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06578">
        <property type="entry name" value="HemD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10090">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036108">
        <property type="entry name" value="4pyrrol_syn_uPrphyn_synt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003754">
        <property type="entry name" value="4pyrrol_synth_uPrphyn_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039793">
        <property type="entry name" value="UROS/Hem4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40082">
        <property type="entry name" value="BLR5956 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40082:SF1">
        <property type="entry name" value="BLR5956 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02602">
        <property type="entry name" value="HEM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69618">
        <property type="entry name" value="HemD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tetrapyrrole biosynthesis uroporphyrinogen III synthase" evidence="1">
        <location>
            <begin position="20"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="271" mass="29704" checksum="9860568664F96A95" modified="2014-10-29" version="1">MPSLEGKVLAITRGKKEAAEFSRLVKKEGGKAIPVQAIEIVPEGRKAVAHFLKLLEEKQHDYCAFMSAQAVAVLFDLGGKGKVASALKSTKVIAVGPKTKKELERRGVRVGMMPDSFSSIGLAKMLSRDSERGKKKIIIPRSAEAGSSNYATKALLDLGMSVDEVFMYTVRTAKITLAWKRFHRMLLDKKIDAIVFTSASNVRSFFEIVDALGGSDDGRKIDRLVQAVVSIGPFTSAELKRRKVRHYEAKDHTVEGTVQAAKKLLIATTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MV04</accession>
    <name>A0A075MV04_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Integrase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02442</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987275.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MV04"/>
    <dbReference type="STRING" id="1459636.NTE_02442"/>
    <dbReference type="GeneID" id="41598150"/>
    <dbReference type="KEGG" id="nev:NTE_02442"/>
    <dbReference type="eggNOG" id="arCOG02125">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079271_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35004:SF7">
        <property type="entry name" value="INTEGRASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35004">
        <property type="entry name" value="TRANSPOSASE RV3428C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="111"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="296" mass="35096" checksum="FFC2560E8F5299DF" modified="2014-10-29" version="1">MKEQGAKNAEIASVQKVSVRRVQQLYSRYRKNGELPVLGRAGRPTKPITEDEVRLVREAYSQYRANAWYLSKYIYKTYNVRINHNRIHRIMVSEGMSSEEARKKQRRKWIRYEREHSNSLWHTDWHEIKDPRWKGKQLIVYEDDASRFVTGYGVFDNVSSQHSVDVLDAAIKKYGRPASVISDNGSPFTTNVEPLDSDKPASFEHYLMKNNKIRHIRARVRHPQSNGKLEKFFDIFERKLKFFNSIEEFMEWYNNVRPHGALNLDEMETPLKAYYARMAPRDVLVDPELLWRDGPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MV27</accession>
    <name>A0A075MV27_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Large ribosomal subunit protein eL39</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpl39e</name>
        <name evidence="7" type="ORF">NTE_02463</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the eukaryotic ribosomal protein eL39 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_075054354.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MV27"/>
    <dbReference type="STRING" id="1459636.NTE_02463"/>
    <dbReference type="GeneID" id="41598170"/>
    <dbReference type="KEGG" id="nev:NTE_02463"/>
    <dbReference type="eggNOG" id="arCOG04177">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_181948_4_0_2"/>
    <dbReference type="OrthoDB" id="65887at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1620.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein-like L39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1620.10">
        <property type="entry name" value="Ribosomal protein L39e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00629">
        <property type="entry name" value="Ribosomal_eL39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000077">
        <property type="entry name" value="Ribosomal_eL39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023626">
        <property type="entry name" value="Ribosomal_eL39_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002316">
        <property type="entry name" value="PRK01242.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00832">
        <property type="entry name" value="Ribosomal_L39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48662">
        <property type="entry name" value="Ribosomal protein L39e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF84512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="52" mass="6314" checksum="CF64F568EBDC8921" modified="2014-10-29" version="1">MAARKNTSRKKRLMKKTRQNQPVPAWVIIRTSRKVRTNPKRRLWRRSDVRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MV33</accession>
    <name>A0A075MV33_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">tRNA-t(6)A37 methylthiotransferase</fullName>
            <ecNumber evidence="11">2.8.4.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">NTE_02468</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:37075"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="Rhea" id="RHEA-COMP:11092"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:74420"/>
            <dbReference type="EC" id="2.8.4.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the methylthiotransferase family. CDKAL1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.4.5" evidence="11"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MV33"/>
    <dbReference type="STRING" id="1459636.NTE_02468"/>
    <dbReference type="KEGG" id="nev:NTE_02468"/>
    <dbReference type="eggNOG" id="arCOG01358">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018697_4_2_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035598">
        <property type="term" value="F:tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.30.20:FF:000002">
        <property type="entry name" value="threonylcarbamoyladenosine tRNA methylthiotransferase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="entry name" value="Methylthiotransferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="entry name" value="tm_1862 like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006466">
        <property type="entry name" value="MiaB-like_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01578">
        <property type="entry name" value="MiaB-like-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00089">
        <property type="entry name" value="MiaB/RimO family radical SAM methylthiotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11918">
        <property type="entry name" value="RADICAL SAM PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11918:SF45">
        <property type="entry name" value="THREONYLCARBAMOYLADENOSINE TRNA METHYLTHIOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01082">
        <property type="entry name" value="B12-binding_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8 11" id="KW-0408">Iron</keyword>
    <keyword evidence="9 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="MTTase N-terminal" evidence="12">
        <location>
            <begin position="70"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="13">
        <location>
            <begin position="201"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AIF84517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="496" mass="55635" checksum="EA315D39002FE460" modified="2014-10-29" version="1">MAFRNRINLTIPSWQKTRYLKKTGFLNQCALPNADRHYMYVRSLKPKLIESIHLIKRQEKEEEEPAKGKEKVWIEAYGCSASMADSEMITGLLKNAGYEIASSRKEGSLNLIVTCSVKDTTEHKMVHRIKQLSKTGKPLVIAGCLPKADRAMVESLSPMASLMGPHSIDRSADVVGSAFSGNRLLALEDSRVAKVNIPRVRINPVVSIVEIASGCMSECTFCQTKLAKGWLYSYRIGDIARQVRDDVSAGCKEVWLTSTDSGCYGRDMGTNLAELLRACAGIDGDFKIRVGMLNPQYMPDMIGEIADVYARNDRLFRFIHMPVQSGSERILRKMKRGHTAQVFSEAVKTLRAKMPDFTISTDIIVGFPNETEEDFQRTLDLLNETQPDVVNISRYSARPGTESARMKNRVSSQVAKERSARLTKLVRDIAKKRNASWKGWQGEIVIDELGKVAQGRNYAYKSVVLADKPDNFKLGEKIRVEVYDFSSFSLKARAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVH2</accession>
    <name>A0A075MVH2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Signal peptidase I</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">NTE_02619</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701194.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVH2"/>
    <dbReference type="STRING" id="1459636.NTE_02619"/>
    <dbReference type="GeneID" id="41598312"/>
    <dbReference type="KEGG" id="nev:NTE_02619"/>
    <dbReference type="eggNOG" id="arCOG01739">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1444624_0_0_2"/>
    <dbReference type="OrthoDB" id="4822at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.109.10">
        <property type="entry name" value="Umud Fragment, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019756">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001733">
        <property type="entry name" value="Peptidase_S26B"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02228">
        <property type="entry name" value="sigpep_I_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806:SF6">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00501">
        <property type="entry name" value="SPASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="165"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S26" evidence="12">
        <location>
            <begin position="21"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIF84662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="187" mass="20956" checksum="F876290FD7B6101F" modified="2014-10-29" version="1">MNEDEKAKMSSAFPRKYIIALVIFAVIAFAVVVTIRYTTNTFNPFFVVASDSMVPTLQVGDLILMKRVSDGDADSSFNDIKVGDIILFKNPHEVDDETGQPITIVHRVVEINDTADNRIIKTKGDNNPESIADLDYPIYKSYYIGKVMYVIPAIGTLEISPYRNYVFVGISVTMIATLIFIFRRGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVL7</accession>
    <name>A0A075MVL7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01259</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700117.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVL7"/>
    <dbReference type="GeneID" id="41597065"/>
    <dbReference type="KEGG" id="nev:NTE_01259"/>
    <dbReference type="eggNOG" id="arCOG08664">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1773075_0_0_2"/>
    <dbReference type="OrthoDB" id="5739at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="146" mass="17116" checksum="FC75DA9F6806593E" modified="2014-10-29" version="1">MNLKEANELFRRAIIKAYFEPQLLKMDYRKSTVKHPAIGDDGLTVDSILHLYFDVVTGNDYPDGDEWFSVEYIFPHSIKLHDSLKGPDYFTTLSVSEGKHYWRHRELVRFKYGKSKKLQESLEFLDKKYKELSKGLHDSGVVNQLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVU8</accession>
    <name>A0A075MVU8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metal-dependent hydrolase, beta-lactamase superfamily II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVU8"/>
    <dbReference type="STRING" id="1459636.NTE_03244"/>
    <dbReference type="KEGG" id="nev:NTE_03244"/>
    <dbReference type="eggNOG" id="arCOG00503">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036012_2_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07713">
        <property type="entry name" value="DHPS-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041712">
        <property type="entry name" value="DHPS-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052926">
        <property type="entry name" value="Metallo-beta-lactamase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13754:SF18">
        <property type="entry name" value="7,8-DIHYDROPTERIN-6-METHYL-4-(BETA-D-RIBOFURANOSYL)-AMINOBENZENE-5'-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13754">
        <property type="entry name" value="METALLO-BETA-LACTAMASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="1">
        <location>
            <begin position="83"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="335" mass="36912" checksum="8F987EBD6DECD68F" modified="2014-10-29" version="1">MYKTAPKKHFLSNAHQNYMHMLLREVEKAVVTCLVDNNVDVLLPNTKVAQRPSLAENWYEQPLIAEHGFSAAITVVESSNWKERRILLDSGLDPLAAAYNADVLGFDLSTCELVISSHGHIDHAGGLLNIRRKMNAEQKIPLVLHKDAFRNRMVKFQDGRTINLPAPKRSLLAGAGYEITEKHSRSTWLDDSILVTGEIARTNNFEKGFPNHYSEAEDGEMENDPLIKDDQAVILNVKGKGLVVITGCGHAGIINTLNFAKELTGQDTIYAVIGGMHLTGSLFEPVIPKTVDELEKLSPTFVVPCHCSGLKAANEIAAKMPHAFTQNSVGTSYVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVX4</accession>
    <name>A0A075MVX4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701719.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVX4"/>
    <dbReference type="STRING" id="1459636.NTE_03259"/>
    <dbReference type="GeneID" id="41598914"/>
    <dbReference type="KEGG" id="nev:NTE_03259"/>
    <dbReference type="HOGENOM" id="CLU_121269_0_0_2"/>
    <dbReference type="OrthoDB" id="11158at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="203" mass="21679" checksum="350DAE1303AE5F8F" modified="2014-10-29" version="1">MPADVNNKGRVIAGVAIGAAVAYFAIAVLVLPGAYVPMMTPPKPEPVVTDVSVSNSTIELGQSFALRVNATNQGDHADRQIVSVAFPNATSTDGIVTVQEENFKQGATFIETGRDIGSGYAGVAQKVKAQYPSVEIFSSPWQKGESFAITLSVKPPQEGRFVFFVKAIGFPHNGDQAHWPSSGTLDHQNEYVSVYSVYVMTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWK6</accession>
    <name>A0A075MWK6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NTE_02997</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701502.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWK6"/>
    <dbReference type="STRING" id="1459636.NTE_02997"/>
    <dbReference type="GeneID" id="41598667"/>
    <dbReference type="KEGG" id="nev:NTE_02997"/>
    <dbReference type="eggNOG" id="arCOG00193">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_2"/>
    <dbReference type="OrthoDB" id="10909at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03293">
        <property type="entry name" value="ABC_NrtD_SsuB_transporters"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050166">
        <property type="entry name" value="ABC_transporter_ATP-bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42788:SF13">
        <property type="entry name" value="ALIPHATIC SULFONATES IMPORT ATP-BINDING PROTEIN SSUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42788">
        <property type="entry name" value="TAURINE IMPORT ATP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF85032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="260" mass="28911" checksum="EE5A96F56B5D0E65" modified="2014-10-29" version="1">MAKLEARNIGKHFNSVQGGGQSQQQVSAIDNVNLSIEDGQFVCLVGPSGCGKTTFLNILAGLDRPSEGEVVLDGKPVTETGPERVMVFQENALFPWLRVIDNVEFGLMVKGVEKAKRNGIAMQYLEMMQLTKFADAYTYQLSGGMKQRVAIARALAIDPEVLLMDEPFAALDSQTRDLLLVELQLIWARTKKTIVFITHNITESVCLGDKVAVFTKRPGTIKKEVAVDYRRPRLPEDDGLREYQRKVLDELKGEIAAKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MX81</accession>
    <name>A0A075MX81_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cell division protein 48 (CDC48), N-terminal domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_01849</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700595.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MX81"/>
    <dbReference type="STRING" id="1459636.NTE_01849"/>
    <dbReference type="GeneID" id="41597613"/>
    <dbReference type="KEGG" id="nev:NTE_01849"/>
    <dbReference type="eggNOG" id="arCOG01308">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_747238_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000007">
        <property type="entry name" value="AAA family ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003338">
        <property type="entry name" value="CDC4_N-term_subdom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02359">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01073">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CDC48 N-terminal subdomain" evidence="3">
        <location>
            <begin position="15"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF83909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="370" mass="40190" checksum="922D1F94704EED93" modified="2014-10-29" version="1">MAYDVASFNRDKKVSLTVREAYALGRHRGIARLHRDLLSALGLANGDIIELGGGRRTYAKVHELYPTDQEKDIIRLDEILRTNVAVGIGGKVSVTPAGKEIPQAESVIMAPLAEALSFVSEDLLAQQLDSIPVTAGDLLVTHSFREMVVFRVVEVRLCTDKPSNAGAAIITKDTKLAVRPKPVARYQQTLKYEAGLRGLRAPGMTNKGPIDLTIVARGIVDESIENDYQESEVVSKGVPKSTDRSTSEQGVVLTLELTLSASRFVNEMRTFRRLVPPNERARAIIDRCMDSAIKVVNGANAKLSPSTAEFTPTTPAHEMFRLNKENSAKLSLLHESVFGAAEKILNKWSAIAAGVKDEEGETGGGDLFIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MXB0</accession>
    <name>A0A075MXB0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MXB0"/>
    <dbReference type="KEGG" id="nev:NTE_01880"/>
    <dbReference type="HOGENOM" id="CLU_2581215_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="80" mass="9003" checksum="C1C32D9EF95C59F9" modified="2014-10-29" version="1">MARTEGVWDGSWQKWHTCHTCHGRLGLQPAFIPQEIISEDGQCMPQNSCRMRVGQAILLLYVSAKSVVIILCKVYSHDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MXL2</accession>
    <name>A0A075MXL2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative glycerate kinase</fullName>
            <ecNumber evidence="7">2.7.1.165</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NTE_01981</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.165" evidence="7"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700691.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MXL2"/>
    <dbReference type="STRING" id="1459636.NTE_01981"/>
    <dbReference type="GeneID" id="41597729"/>
    <dbReference type="KEGG" id="nev:NTE_01981"/>
    <dbReference type="eggNOG" id="arCOG04170">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032279_1_1_2"/>
    <dbReference type="OrthoDB" id="10741at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043798">
        <property type="term" value="F:glycerate 2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008887">
        <property type="term" value="F:glycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10180:FF:000001">
        <property type="entry name" value="Glycerate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10180">
        <property type="entry name" value="Glycerate kinase, MOFRL-like N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1480.10">
        <property type="entry name" value="MOFRL domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037035">
        <property type="entry name" value="GK-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038614">
        <property type="entry name" value="GK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007835">
        <property type="entry name" value="MOFRL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025286">
        <property type="entry name" value="MOFRL_assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039760">
        <property type="entry name" value="MOFRL_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12227">
        <property type="entry name" value="GLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12227:SF0">
        <property type="entry name" value="GLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13660">
        <property type="entry name" value="DUF4147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05161">
        <property type="entry name" value="MOFRL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82544">
        <property type="entry name" value="GckA/TtuD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MOFRL-associated" evidence="6">
        <location>
            <begin position="23"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="MOFRL" evidence="5">
        <location>
            <begin position="336"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF84039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="455" mass="47489" checksum="502BB086795CD752" modified="2014-10-29" version="1">MIIKNRADLERAHGKGAKIVLGAVEAAIKSVEPGMLVKRAVKAGKDSITFSDIYKKSFTIRDFKDVYVVGAGKAAGPMAAALSKMLKGRVTGGAINVPKRTRHAAAIDRISITYASHPVPDESGVRGAKRITGVLEKANEDDLAIVLISGGGSALLPLPAEGISLLDKQRVTKDLLASGASIFEINTVRKHLSAVKGGQLARRARCRVVSLVLSDVVGDDLAVIASGPTFPDPTTYSDALEIIKRHKIRNARVARHLERGAAGKIADTPKPGDPLFSRVKNVLVGNNQVACESAARYLALRQIPAVESLGSEFDGEAQDFGRFVARVASGRSGPFALVAGGETTVRLGNTAANNGKGGRNQEAALACALSLNDPKGITAAFVGTDGIDGNSDAAGAIVSDRSAAGIAAVGPANVQNHLRSHDSYHALKKMKSLIFTGYTGTNVNDIAIALRLNTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MXR0</accession>
    <name>A0A075MXR0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TrbL/VirB6 plasmid conjugal transfer protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_03369</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701810.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MXR0"/>
    <dbReference type="GeneID" id="41599015"/>
    <dbReference type="KEGG" id="nev:NTE_03369"/>
    <dbReference type="HOGENOM" id="CLU_433208_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="610"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF85397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="631" mass="65832" checksum="CF74880314637B27" modified="2014-10-29" version="1">MVDFITPIVIVIILVALVAIVNAWVIGSADKSFFELMVKMPKFVDKPDATLADYEAPPPSSSSSHAPSAKPGMIETYHNLRLIAIFVMAGAFILGMILFLGEEFGIQKKGQAIELVANALIYSLFLMVFPVLWDSVATGVEYLNVYILNPANPTPENAAARAKDLFIKLGGINTEFDMGKLLEGTAKALVGDQSGLTQLFHDVMTAIFRAFLAALIFMMMFIIGTIRIVLTASIIVGLPMILAIKLVPWVRRPADRLLETLYGLVVATVISSMVVVAGGAYLDTLPKDSVVENFQAFVAAAAVIILAIFMPVMLSPMLGSVVSSITGMVTSSLMAGVVAGGSATMGAARGAAGALGYGGAAPGSLSGMGMGSDGGGAFGGGMAAASLGSRLAQNAMQGICGANNMGMGSRSTQQQDLAPEIVAAKEERAMRYLPPSGRAPVTVSSPATGSAPSIRPEPPLAGTSKPVVETPSSYRADVSTIEDAAAAIKTPAKESSRMPAFAIQPGSVVFAPDPTPLSSAQKLHMGAKGTIIGGMSGLAQGLGKGLAMESRSAGMADIGKAISSAFGGGFDFDKDGNNYFEFDDMKKGVEKLRELATKQVRMVSETYASEAEGKQGEEIQDFLARTKREIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MXY3</accession>
    <name>A0A075MXY3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">YokE-like PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02088</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_193354067.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MXY3"/>
    <dbReference type="STRING" id="1459636.NTE_02088"/>
    <dbReference type="GeneID" id="41597822"/>
    <dbReference type="KEGG" id="nev:NTE_02088"/>
    <dbReference type="eggNOG" id="arCOG11950">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_176746_0_0_2"/>
    <dbReference type="OrthoDB" id="6444at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.50">
        <property type="entry name" value="Bacterial Pleckstrin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037063">
        <property type="entry name" value="PHb_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="107" mass="12273" checksum="03D4322885EA132A" modified="2014-10-29" version="1">MVLNDYLLPSENIRLASDDEVEYGDKKYRIVITDKRFILYARRGTVFKSDDVVSERLQAIHGFKYSEKGTLFRTATISIITNAKMEIRGSPDRMKPLFHTLQSTIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MY17</accession>
    <name>A0A075MY17_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03519</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MY17"/>
    <dbReference type="STRING" id="1459636.NTE_03519"/>
    <dbReference type="KEGG" id="nev:NTE_03519"/>
    <dbReference type="HOGENOM" id="CLU_3147801_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="48" mass="5814" checksum="32E75B11EA3A51DC" modified="2014-10-29" version="1">MREQEKERESIVIIINEIVREGRWCSEAAPPFLLCQLELELIQWKWVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MYE9</accession>
    <name>A0A075MYE9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Thioredoxin-disulfide reductase</fullName>
            <ecNumber evidence="7">1.8.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NTE_02240</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.8.1.9" evidence="7"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MYE9"/>
    <dbReference type="STRING" id="1459636.NTE_02240"/>
    <dbReference type="KEGG" id="nev:NTE_02240"/>
    <dbReference type="eggNOG" id="arCOG01296">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031864_5_1_2"/>
    <dbReference type="OrthoDB" id="27340at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019430">
        <property type="term" value="P:removal of superoxide radicals"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050097">
        <property type="entry name" value="Ferredoxin-NADP_redctase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008255">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005982">
        <property type="entry name" value="Thioredox_Rdtase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01292">
        <property type="entry name" value="TRX_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48105">
        <property type="entry name" value="THIOREDOXIN REDUCTASE 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00573">
        <property type="entry name" value="PYRIDINE_REDOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="6">
        <location>
            <begin position="39"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF84294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="348" mass="37947" checksum="93CA5DA351A9F351" modified="2014-10-29" version="1">MFNANNLTTIIQNHPPNGLLRGQPKISLTSLAETIQKHYDVIIIGSGPAGYTAGVYTSRAKLSVLVISGTLPGGQLMTTSEVENYPGFPSGIFGPELMMNMRQQAERFGAVIIDDEVTQVDFKQRPFKITTHSETYDSDAVIICTGASPRKLGIPAEQQFGGRGVSYCATCDGPFFKGEDIVVVGGGDTAVEEATFLTKFGKSVKLVHRRDTLRASAIMQEKAKENPKIEFLWNNVVTDIKGDKKVATVSLKNLKTGKETTVKAGGLFVAIGHEPNTSIFKDQVELDDKGYMVLKENTRTSVEGVFAAGDVHDHRYRQAVTAAGFGCMAAIDVERWLSEKRHSNNKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MYP9</accession>
    <name>A0A075MYP9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF192 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02337</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385424.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MYP9"/>
    <dbReference type="GeneID" id="41598053"/>
    <dbReference type="KEGG" id="nev:NTE_02337"/>
    <dbReference type="eggNOG" id="arCOG03116">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097039_1_2_2"/>
    <dbReference type="OrthoDB" id="6763at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1140">
        <property type="entry name" value="Protein of unknown function DUF192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003795">
        <property type="entry name" value="DUF192"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038695">
        <property type="entry name" value="Saro_0823-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37953">
        <property type="entry name" value="UPF0127 PROTEIN MJ1496"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37953:SF1">
        <property type="entry name" value="UPF0127 PROTEIN MJ1496"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02643">
        <property type="entry name" value="DUF192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="163" mass="18151" checksum="6901DEDF77DF8391" modified="2014-10-29" version="1">MARKSAVLIPVIIAAVAVGGLGLVFIPQDIKNRSPDFPKGTVRINDDVITVEIAQSIAEKQRWLTFRQDMLPTDTAMLLKYDKPDLYDIWMLNVNYNLDLIWFDKDGNAVYMKKDVPPCGNVLDQQGCTYKTTKPAMYILAGTAGFADAHRIDIGTKMNIISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MYQ8</accession>
    <name>A0A075MYQ8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein-glutamate methylesterase/protein-glutamine glutaminase</fullName>
            <ecNumber evidence="5">3.1.1.61</ecNumber>
            <ecNumber evidence="5">3.5.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">cheB</name>
        <name evidence="8" type="ORF">NTE_02347</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-glutaminyl-[protein] + H2O = L-glutamyl-[protein] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16441"/>
            <dbReference type="Rhea" id="RHEA-COMP:10207"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="EC" id="3.5.1.44"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 5">
            <text>[protein]-L-glutamate 5-O-methyl ester + H2O = L-glutamyl-[protein] + methanol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23236"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="Rhea" id="RHEA-COMP:10311"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:82795"/>
            <dbReference type="EC" id="3.1.1.61"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.</text>
    </comment>
    <comment type="PTM">
        <text evidence="5">Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CheB family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.61" evidence="5"/>
    <dbReference type="EC" id="3.5.1.44" evidence="5"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700980.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MYQ8"/>
    <dbReference type="STRING" id="1459636.NTE_02347"/>
    <dbReference type="GeneID" id="41598063"/>
    <dbReference type="KEGG" id="nev:NTE_02347"/>
    <dbReference type="eggNOG" id="arCOG02382">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_51_0_2"/>
    <dbReference type="OrthoDB" id="2857at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008984">
        <property type="term" value="F:protein-glutamate methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050568">
        <property type="term" value="F:protein-glutamine glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16432">
        <property type="entry name" value="CheB_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17541">
        <property type="entry name" value="REC_CheB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.180">
        <property type="entry name" value="Methylesterase CheB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00099">
        <property type="entry name" value="CheB_chemtxs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008248">
        <property type="entry name" value="CheB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035909">
        <property type="entry name" value="CheB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000673">
        <property type="entry name" value="Sig_transdc_resp-reg_Me-estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001965">
        <property type="entry name" value="PRK00742.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42872">
        <property type="entry name" value="PROTEIN-GLUTAMATE METHYLESTERASE/PROTEIN-GLUTAMINE GLUTAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42872:SF6">
        <property type="entry name" value="PROTEIN-GLUTAMATE METHYLESTERASE_PROTEIN-GLUTAMINE GLUTAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01339">
        <property type="entry name" value="CheB_methylest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000876">
        <property type="entry name" value="RR_chemtxs_CheB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52738">
        <property type="entry name" value="Methylesterase CheB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50122">
        <property type="entry name" value="CHEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="22"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="CheB-type methylesterase" evidence="7">
        <location>
            <begin position="183"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="315"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF84399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="374" mass="40137" checksum="40B0B4AEC94AB19F" modified="2014-10-29" version="1">MMTSSSTAFASGNSSSSNDKIQVMIVNDSMYMRSLFSDLISTSQRLQVSDTANDGVDALRKVRKSRPDVVLLDLEMPNMDGLSFIENVMPADPLPVVLVSSYGQKGADVVFDALEMGAVDFVPIPQDDPEKMRDLRSTLVSKLEIAAQTKNRLRLKMAKAARKQASTAVRARTPPSLKTMANGHEDSAVVVIGASTGGPGVVGEIMSRLSADLPAGVLIVQHMPEGFTKSFADRLNGISKMPVREAREGDAIRPGTALLAPGDYHLLVKPSRVVELNKSPRRFGVRPAINMSMVSASQVYGRKTVGVLLTGMGHDGAFGMKMIKRKGGMTVGQDESSSVVFGMAKAAAEMDAVDRLLPTELIPEEIERMVASVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MZ18</accession>
    <name>A0A075MZ18_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02449</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MZ18"/>
    <dbReference type="KEGG" id="nev:NTE_02449"/>
    <dbReference type="HOGENOM" id="CLU_1369471_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="199" mass="23504" checksum="F1C56C5DC1E2985E" modified="2014-10-29" version="1">MKNIKTYLTHFPVTSYLEADILSKETTWRIMNYIRQAGAKGITAEEITQKEKIPASVVYSTLKELYRLQFIFLYPREKKGKGERRKRFVCERSTWGKYGIDEEFDAALKVSGLHERITEEIRQPVMKALRETYDHFSTKKELQRFLPTKQTNICPNCQRSHEAMEFFYATLLRSVDLMITESDEFKKFLIDKGYASDEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MZF4</accession>
    <name>A0A075MZF4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thiol-disulfide isomerase-like thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701166.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MZF4"/>
    <dbReference type="STRING" id="1459636.NTE_02585"/>
    <dbReference type="GeneID" id="41598279"/>
    <dbReference type="KEGG" id="nev:NTE_02585"/>
    <dbReference type="eggNOG" id="arCOG03562">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044955_0_0_2"/>
    <dbReference type="OrthoDB" id="9006at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041017">
        <property type="entry name" value="Thioredoxin_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050553">
        <property type="entry name" value="Thioredoxin_ResA/DsbE_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42852:SF13">
        <property type="entry name" value="PROTEIN DIPZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42852">
        <property type="entry name" value="THIOL:DISULFIDE INTERCHANGE PROTEIN DSBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17991">
        <property type="entry name" value="Thioredoxin_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="3"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="334" mass="37843" checksum="A7E74C9941B3DB37" modified="2014-10-29" version="1">MQLIPATPAPEFKEISGWANSSPLSIKSLKGKVVILDCWTYTCIFCLRTIPTLKRLQEKYGKYGLQVVQAHSAEYHFATDHANISRALARYNVSNLPVAFDTKNKTWEAYGNMYWPKHVIIDHAGFVRYEHAGYGDITEFEPVIAELLEEAGNKPSSIDYDDKNPDDEIFDTYGMHFAGMAPEICVGYSRMRRFGNNQTFKPDEPSVAVDQGSHLDNTVYLRGKWIWQREGVQFAPGGKETKPAIIMKYNSAKRVHGIMGTSDGRQGRAEVRLDGNPLSKEQLGRDARLENGASIVNIEWPFMHNLVRTGKPEVHEIEIIPRSDNFVFYTFVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MZL6</accession>
    <name>A0A075MZL6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EMAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_02641</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MZL6"/>
    <dbReference type="STRING" id="1459636.NTE_02641"/>
    <dbReference type="KEGG" id="nev:NTE_02641"/>
    <dbReference type="eggNOG" id="arCOG01136">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065946_3_1_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051270">
        <property type="entry name" value="Tyrosine-tRNA_ligase_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11586">
        <property type="entry name" value="TRNA-AMINOACYLATION COFACTOR ARC1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11586:SF37">
        <property type="entry name" value="TRNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="TRNA-binding" evidence="3">
        <location>
            <begin position="37"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF84684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="138" mass="15040" checksum="244C70CAD4D10F4A" modified="2014-10-29" version="1">MHTNLIAPLLLKKEEYTNMSEQGHDNNNNSNIITFDEFIKVQLRIGKVVSAEAIPGMKKVFKAIVDIGTEKREVAVGAALWIKPEDFVGRTVVICTNLAPRKIGDMTSNGMLLAADGPEGRPVFLTTTEEAPLGAPIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MZT2</accession>
    <name>A0A075MZT2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Copper chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02697</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MZT2"/>
    <dbReference type="STRING" id="1459636.NTE_02697"/>
    <dbReference type="KEGG" id="nev:NTE_02697"/>
    <dbReference type="eggNOG" id="arCOG02764">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134973_10_4_2"/>
    <dbReference type="OrthoDB" id="10245at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMA" evidence="1">
        <location>
            <begin position="10"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="82" mass="9550" checksum="A320527C656F5F11" modified="2014-10-29" version="1">MIYLVQMAVQKALFKVVGMYCTTCKPIVEKQLKGEQAIKKIDLDFMTDSVIVEYDPALITKEEIKQRLERSGYQFVRRTEAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N0G1</accession>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name evidence="2" type="ORF">NTE_02938</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
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            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="eggNOG" id="arCOG10526">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1003322_0_0_2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="277" mass="29820" checksum="F5CDB184DDE240BB" modified="2014-10-29" version="1">MEEIRKEITEIKRGRKNLVVALVGAIIAINIIVLATSQSDAIVVTSDLSRILTVGAAAVISIIVVARQNVTGIFGRAYLALAAGLVLWVAAESTWGYYELVLQIERPFPSIADALWLSAYGPIGFHLFSMARFYGRGVGKYKVAAVIAGMSVFVGLCITELAGVSELQGEGAELAIAISIAYPLLDTALFMPAILIVLNSGKGYLTSIPWIFIGWMALGVADTLLGIAQVQNFDGDLFMINAFYVIAYLAMAAGLWWYNRFFIFDKAKLGKKPAATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N1W6</accession>
    <name>A0A075N1W6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N1W6"/>
    <dbReference type="KEGG" id="nev:NTE_03421"/>
    <dbReference type="HOGENOM" id="CLU_3282672_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="40" mass="4423" checksum="6CC99708158E2B9B" modified="2014-10-29" version="1">MSTIKPSGWLGEILHDMDHALPVTRVHGAQVTERDTVNLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLH9</accession>
    <name>A0A075MLH9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA methylase/Development and cell death domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_00039</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699189.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLH9"/>
    <dbReference type="STRING" id="1459636.NTE_00039"/>
    <dbReference type="REBASE" id="90021">
        <property type="entry name" value="M.NevSR1ORF39P"/>
    </dbReference>
    <dbReference type="GeneID" id="41595991"/>
    <dbReference type="KEGG" id="nev:NTE_00039"/>
    <dbReference type="eggNOG" id="arCOG00129">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_722831_0_0_2"/>
    <dbReference type="OrthoDB" id="38200at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013989">
        <property type="entry name" value="Dev_and_cell_death_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002941">
        <property type="entry name" value="DNA_methylase_N4/N6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46444:SF9">
        <property type="entry name" value="DCD (DEVELOPMENT AND CELL DEATH) DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46444">
        <property type="entry name" value="DCD (DEVELOPMENT AND CELL DEATH) DOMAIN PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10539">
        <property type="entry name" value="Dev_Cell_Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01555">
        <property type="entry name" value="N6_N4_Mtase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00767">
        <property type="entry name" value="DCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51222">
        <property type="entry name" value="DCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DCD" evidence="4">
        <location>
            <begin position="10"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="372"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="382"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF82123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="397" mass="44541" checksum="B17BD2C99938414B" modified="2014-10-29" version="1">MVSSAAVAAAGRQGRIFACTSKTEKECLDRMLFATGRLYGEGVLAIKKGDPLFLLNLDTDVLYGTFAADSDGKKDIEPEAWAGRYPYQVRVSQQNGKAAHSIKGAKKILSQMGLGWRDALSPAAAEALSNYLENPNGKIASFEKDEEDEKPRLESTTLWDYPRQSYGKTPKGSNKYAGVTPAFAIYNMVKRYTEPGDLVLDPMAGSGTTLDVCREEGRRCRAFDISPVRPDIVQNDARKIPLADESVDMVFIDSPYGDNIDYNDQPGNIGKISAETDEFYDELEKVMAECRRVMKPGKAIGWVIGDQWVHKKFTPVGFKVYERLCKHFETVDIICLARRGQTSNTGVWHNRALRFNFYLRGFKYLFIMRKPDGNSASPAGKKEKKKKVSWTQYTRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLJ2</accession>
    <name>A0A075MLJ2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00249</name>
    </gene>
    <organism evidence="1 2">
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        <lineage>
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            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLJ2"/>
    <dbReference type="STRING" id="1459636.NTE_00249"/>
    <dbReference type="KEGG" id="nev:NTE_00249"/>
    <dbReference type="HOGENOM" id="CLU_3263606_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="41" mass="4678" checksum="E7CCDE8C57F7936F" modified="2014-10-29" version="1">MEANLQALFEAVKRSDIEVFEIVDVRRSPSKCLPNTKREAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MM21</accession>
    <name>A0A075MM21_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00091</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MM21"/>
    <dbReference type="KEGG" id="nev:NTE_00091"/>
    <dbReference type="HOGENOM" id="CLU_2712605_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="72" mass="8095" checksum="1D0D9992AE4CE672" modified="2014-10-29" version="1">MINNECHAYTGGMGGKQREEEQVLLTLPNIKYLVEGLEALLMTDLDGDKRAKVIKLRDDLASYVNSIFSDYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MM33</accession>
    <name>A0A075MM33_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleotidyltransferase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00221</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699316.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MM33"/>
    <dbReference type="STRING" id="1459636.NTE_00221"/>
    <dbReference type="GeneID" id="41596142"/>
    <dbReference type="KEGG" id="nev:NTE_00221"/>
    <dbReference type="eggNOG" id="arCOG05472">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1197616_0_0_2"/>
    <dbReference type="OrthoDB" id="165795at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="237" mass="27074" checksum="AD9856372299A16E" modified="2014-10-29" version="1">MLRDDLESRETEIIRILSSLPKGFFVVIGGYAVSALSIHRFSVDCDMVILRKDAMKFSDLLKKEGYRKEKSAKGFDEAHHSEVDIYVKSFGGMRVSVDLFINGITSRKTEAWWNYEYIKENSTEAIVVGTKNSASTTVPTKELLMVMKMHSARDVDMRDIVMLSEGVDWTAVLKHAMRRTKSILVKQVTEIIGRMEEEQFIQSLRAAFGLRRNIEPLISDCKKNLSKLRQKIESSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MM96</accession>
    <name>A0A075MM96_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00153</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MM96"/>
    <dbReference type="STRING" id="1459636.NTE_00153"/>
    <dbReference type="KEGG" id="nev:NTE_00153"/>
    <dbReference type="eggNOG" id="arCOG00798">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100469_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.91.30">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="241" mass="27931" checksum="521FE54E829714F9" modified="2014-10-29" version="1">MVQISKASHMGGRSSSVLRKFLAGLIIVDALIAIWIIAIAGNWDPRLLIGWAVLNVVIAISALAIIKSSSRRKGSSSLQARHTRYYYSPSQEEERHTRDSDDDYNSDFHRAAYITMNGETVKSKGEKLLADYFYQNNIVYQYERAAWTTGTRFKSKRMISKPDFYLPDYDVYVEYWGMVNTKDKNNRADYIKSMEWKMTKYDENKIKFVSIYPNNLDDLDRIFKARLRKATTTVADAKRDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MML9</accession>
    <name>A0A075MML9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DnaJ-class molecular chaperone with C-terminal Zn finger domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_00416</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MML9"/>
    <dbReference type="STRING" id="1459636.NTE_00416"/>
    <dbReference type="KEGG" id="nev:NTE_00416"/>
    <dbReference type="eggNOG" id="arCOG00349">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG02846">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1232812_0_0_2"/>
    <dbReference type="OrthoDB" id="11397at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43096">
        <property type="entry name" value="DNAJ HOMOLOG 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43096:SF52">
        <property type="entry name" value="DNAJ HOMOLOG 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13370">
        <property type="entry name" value="Fer4_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="6"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF82498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="213" mass="24382" checksum="0CB2EA7E24FB75D5" modified="2014-10-29" version="1">MADNKGYYAILGVPERASQLEIKKAYRRLARKYHPDRNGTVHAEDMIKKINAAYEVLSDIHKREQYDKSSFGDVVEQEAHVQQEEEPRHVQEQEEHAAATEYYAAEQQQHARAKKSEAKKDTSDYYYGGPTYIETPKSRFHIIVEPSLCMAFGSCETLAPKVFVVEKNKRVNPKARVESEVGADYETIHAAAQMCPTKAIRIIDRYTGEQLFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMQ5</accession>
    <name>A0A075MMQ5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00477</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699507.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMQ5"/>
    <dbReference type="GeneID" id="41596351"/>
    <dbReference type="KEGG" id="nev:NTE_00477"/>
    <dbReference type="HOGENOM" id="CLU_1598934_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="166" mass="18571" checksum="99409B651DB753D9" modified="2014-10-29" version="1">MPQCRRFFALVIKNTHIFNIKPTAGEKPLNRHLDGSASAAIAVVVIAGVEPFAIDGQRSNDDHHHSKTSGSSNKKKNMAQKPETMEETMDVLARAEVFDYHAGICYYCCTQLQWQDFSKEWTLTYTHKGRTGIPTTVIALFAPTCLSCDRRVATQPLRKGGIFLQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMZ8</accession>
    <name>A0A075MMZ8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00557</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699568.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMZ8"/>
    <dbReference type="STRING" id="1459636.NTE_00557"/>
    <dbReference type="GeneID" id="41596425"/>
    <dbReference type="KEGG" id="nev:NTE_00557"/>
    <dbReference type="eggNOG" id="ENOG502N59H">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1092571_0_0_2"/>
    <dbReference type="OrthoDB" id="11314at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="261" mass="29021" checksum="A61F2DA187EF01E8" modified="2014-10-29" version="1">MNLINNINRHLFTQVNVDSGSLSILSAVIHRFAQPGEYEGIVMKGPIKTQRFTVTVVEDNNIISSSSQAAAATNTNAAAAEQIKVDLKDTASDRFTLRRGGYGVFYVSTGPGGYVVEIRKYEKGSQVKVFDSSELKEDDIFSTTIIRPGTYSVTNTLNNAKAELMVNYPEIGKTQRNPQPIKIECTAQNQINPNRIRIDPSQGLVFTSKTPFRIKIELTKPEDRPSRLARKEGTLAQRIAQQKGQEKKIIRRYRLMPSGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MN33</accession>
    <name>A0A075MN33_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Family 3 adenylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699796.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MN33"/>
    <dbReference type="STRING" id="1459636.NTE_00850"/>
    <dbReference type="GeneID" id="41596693"/>
    <dbReference type="KEGG" id="nev:NTE_00850"/>
    <dbReference type="eggNOG" id="arCOG07810">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089864_0_0_2"/>
    <dbReference type="OrthoDB" id="2830at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009190">
        <property type="term" value="P:cyclic nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="1">
        <location>
            <begin position="41"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="221" mass="23963" checksum="E18D3216F85427D4" modified="2014-10-29" version="1">MSSDDQYRTHTAVQSGAEHDVKEKQQIDLLLQFFSSTRNYCVGIVDMVGSTAATMKMAPDKVSRFYSIFLNGLADVVSRNGAVVVKNIGDSLLYYFPATESGDALAFEQVLRCCFAMIEKGPQLNALLGKEGLPEIKYRISCEYGAVVVARMSTSSVNDIFGSPVNMASKMNPLAPPCGVVIGQGLYEMAKNVPGYAFSEVKGAPMFSETGYSLYIVDLAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MN55</accession>
    <name>A0A075MN55_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rubrerythrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987090.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MN55"/>
    <dbReference type="STRING" id="1459636.NTE_00135"/>
    <dbReference type="GeneID" id="41596075"/>
    <dbReference type="KEGG" id="nev:NTE_00135"/>
    <dbReference type="HOGENOM" id="CLU_194244_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="83" mass="9715" checksum="589D0A2FAAA48F80" modified="2014-10-29" version="1">MTTEMSAKHEATRLTNSTYDIIRALEKDADFLYSTVDRYIDDASKENRSDLIGVWNTIKQDKERHVQLLREALAKEAKEERLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MN63</accession>
    <name>A0A075MN63_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative signal-transduction protein containing cAMP-binding and CBS domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_00895</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699834.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MN63"/>
    <dbReference type="STRING" id="1459636.NTE_00895"/>
    <dbReference type="GeneID" id="41596735"/>
    <dbReference type="KEGG" id="nev:NTE_00895"/>
    <dbReference type="eggNOG" id="arCOG00606">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG10404">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040681_12_0_2"/>
    <dbReference type="OrthoDB" id="65817at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051257">
        <property type="entry name" value="Diverse_CBS-Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43080:SF2">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43080">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN CBSX3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="4">
        <location>
            <begin position="13"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="4">
        <location>
            <begin position="80"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="148"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF82971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="184" mass="19815" checksum="A606026BECA53720" modified="2014-10-29" version="1">MQADLERKVGELATPEILVMDELSTVAQAAKAMKKKDSSSVFVSRGSTKDLVGIITERDILYRVVAENMGPFKTTLKEVMSAPLIIIDYSATVLEAILLMRKEGIRRLPVRRDGGIVGVVTLLSITGNIPSKSVEAGQVETSLGSSGIACPYCGSGFESKKDLSKHIDRLHIGSGLLEGDLRQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNB5</accession>
    <name>A0A075MNB5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase propeptide domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNB5"/>
    <dbReference type="KEGG" id="nev:NTE_00215"/>
    <dbReference type="HOGENOM" id="CLU_102442_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025711">
        <property type="entry name" value="PepSY"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03413">
        <property type="entry name" value="PepSY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PepSY" evidence="1">
        <location>
            <begin position="85"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="PepSY" evidence="1">
        <location>
            <begin position="168"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="237" mass="24041" checksum="04E903AC14026666" modified="2014-10-29" version="1">MSSLTEKTRRMFLIPSLLVVGLAVASVIMTAAVGAPSSMLAFAQTTATTPNQAATTTANQTAGTISLTQAAKDFLNDNLNATMIDAASAAEDQVPNGATVAAHFGILQGSLVYNVTVADTDTGNAFNVFVDAASGKILSKSAAFPVDTLGLPAGFDNATKTLIDAADVAENQVQNGMVVAGSIATAAQAEGGALVYLITVADIDNGTLHETRVNPTTGSIISSEVVPLGELHIGDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNE9</accession>
    <name>A0A075MNE9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">von Willebrand factor type A-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00599</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699601.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNE9"/>
    <dbReference type="STRING" id="1459636.NTE_00599"/>
    <dbReference type="GeneID" id="41596462"/>
    <dbReference type="KEGG" id="nev:NTE_00599"/>
    <dbReference type="eggNOG" id="arCOG02900">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_523398_0_0_2"/>
    <dbReference type="OrthoDB" id="8373at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="354"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="526" mass="60025" checksum="B726A8083B0B90D2" modified="2014-10-29" version="1">MSKLEKSVMRNDILLDIATFLARRWSGNDKTVVALAPDKPPATKPDKSQVTLPTLAYYVGTDFQKYRQWRVALWYESMRMRHSSKVLSNEHAFGFLLNTLETKRVEILGLADWEGMENELIFYEGISWQSRQLLNTIYGRYKIAEAFSQYFLTGYVKGELFGGELEKVQKAVEFANEVVKEALDNNYGTEWVEQQIPKLIRMLELDPLVSIPILAPRTRMGASLTQQDVLKQIEKVVRTKKKEKDSEEKSKEIYEGNDVLHEFETLVKESKKTENKGYDSLENFGLSVPDRMDVDETQIYDLDLIQKVKAAFREWKTGWVERHDEMGEELDIETIVESLPKPFLTDVKLSIRSKVVLLLDHSSSIADVETEYKQATVALCEALSYLGVKFAVYAFSTENRQVKCWVVKPPTVKWSLVCARRLVQIKAVGGTPLAEVYGLLQPVLKSFKPDIFVTLTDGEPSDFDAVRAMVLSYRKVGIKMVAIGVGRNLSDAVGIGQNLKYLNYEKTLSVSRLQDMPKKVIKLLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNK8</accession>
    <name>A0A075MNK8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00713</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699693.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNK8"/>
    <dbReference type="STRING" id="1459636.NTE_00713"/>
    <dbReference type="GeneID" id="41596566"/>
    <dbReference type="KEGG" id="nev:NTE_00713"/>
    <dbReference type="HOGENOM" id="CLU_155675_0_0_2"/>
    <dbReference type="OrthoDB" id="375359at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="111" mass="12841" checksum="AEDDAEFEA9D2D071" modified="2014-10-29" version="1">MSRSFRYDLEPAYEPMLTPMERLLEQKVSILCVAEGISRVEMSPIQRLFLTHYRCSTCKLLPLYRLDLSHIKRARCGRCGHLVSFTSAGKYGKMRKKLALMLWQARCEGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNL4</accession>
    <name>A0A075MNL4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNL4"/>
    <dbReference type="KEGG" id="nev:NTE_00320"/>
    <dbReference type="HOGENOM" id="CLU_2678682_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="74" mass="8787" checksum="3965203E48565EA1" modified="2014-10-29" version="1">MTMRCLCERRPKNRDRVGMNTINLPFAAFFRAYRLLQHFSLNEYRMFCPDLEVGSRDMLAILKVQVAVTVYLQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNQ6</accession>
    <name>A0A075MNQ6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methylmalonyl-CoA mutase family protein</fullName>
            <ecNumber evidence="3">5.4.99.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_01108</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.4.99.2" evidence="3"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699993.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNQ6"/>
    <dbReference type="STRING" id="1459636.NTE_01108"/>
    <dbReference type="GeneID" id="41596923"/>
    <dbReference type="KEGG" id="nev:NTE_01108"/>
    <dbReference type="eggNOG" id="arCOG04232">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009523_5_1_2"/>
    <dbReference type="OrthoDB" id="38408at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004494">
        <property type="term" value="F:methylmalonyl-CoA mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.240">
        <property type="entry name" value="Methylmalonyl-CoA mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016176">
        <property type="entry name" value="Cbl-dep_enz_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006099">
        <property type="entry name" value="MeMalonylCoA_mutase_a/b_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006098">
        <property type="entry name" value="MMCoA_mutase_a_cat"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00641">
        <property type="entry name" value="acid_CoA_mut_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48101:SF1">
        <property type="entry name" value="METHYLMALONYL-COA MUTASE, LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48101">
        <property type="entry name" value="METHYLMALONYL-COA MUTASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01642">
        <property type="entry name" value="MM_CoA_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51703">
        <property type="entry name" value="Cobalamin (vitamin B12)-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methylmalonyl-CoA mutase alpha/beta chain catalytic" evidence="2">
        <location>
            <begin position="18"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF83181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="535" mass="60211" checksum="B401105CB18456B0" modified="2014-10-29" version="1">MAKTAENAATTSKKKIVTDSNIPVKRAYKKADIKGLKDEDPGKYPFTRGLYPEMYRERVWTMRQYSGFGSADETNKRFKFLLDKGQTGLSLAFDLPTQTGRDSDHPMSEGEVGRTGVAISSIKDMMTCFEGIPLDKVSTSMTINSTASTLLSLYITVAESQGVKPDQLRGTTQNDILKEYIARNTYIYPPKPSMRLIGDMIEYCSKKVPQWYPVSISGYHIREAGSNAVQELAFTFADAIEYVETCTARGLKVDDFAPRLSFFFCCTMEFFEEIAKFRAARRIYAKIMKERFHARSAKSQHLRFHVQTSGESLTAQQVDNNIVRVATEAMAAVLGGCQSLHTNSRDEALALPTEQSAKVALRTQQIIASETGAIKTVDPMAGSYYVEQLTSEIEEQVWKYLKRIDKMGGAMAAIEKGYFQEEIRNNAYRLKREIDENSRVIVGVNKYQDAHDVEPALNRIDPEIEKKQLARLKEFKAGRDMAKVNAALATLQKNAEKDENLMPHIINCVKSYTTLGEISDTLRGIFGRYEPKISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNV6</accession>
    <name>A0A075MNV6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase, IS605 OrfB family, central region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_00415</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNV6"/>
    <dbReference type="STRING" id="1459636.NTE_00415"/>
    <dbReference type="KEGG" id="nev:NTE_00415"/>
    <dbReference type="eggNOG" id="arCOG00684">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032903_9_3_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Cas12f1-like_TNB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="Cas12f1-like_TNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cas12f1-like TNB" evidence="2">
        <location>
            <begin position="35"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF82497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="136" mass="15568" checksum="45C3D79E1441D924" modified="2014-10-29" version="1">MYYASHYNLIFLERLRVANLTKNHRLARKILDASWSTFKTMLQYKANRVVEVEPAYSSIDCSRCGHPVPKSLAMRTHVCPKCGAVLDRDYNSAINHLQNGIELLRLLPVERREVTPVEIASLRQSKKQEACGFIHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MP88</accession>
    <name>A0A075MP88_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AAA family ATPase, CDC48 subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NTE_00526</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. CDC48 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MP88"/>
    <dbReference type="STRING" id="1459636.NTE_00526"/>
    <dbReference type="KEGG" id="nev:NTE_00526"/>
    <dbReference type="eggNOG" id="arCOG01308">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_12_3_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19511">
        <property type="entry name" value="RecA-like_CDC48_r2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000007">
        <property type="entry name" value="AAA family ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000057">
        <property type="entry name" value="AAA family ATPase, CDC48 subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000018">
        <property type="entry name" value="Cell division control 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000012">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005938">
        <property type="entry name" value="AAA_ATPase_CDC48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004201">
        <property type="entry name" value="Cdc48_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003338">
        <property type="entry name" value="CDC4_N-term_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01243">
        <property type="entry name" value="CDC48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF171">
        <property type="entry name" value="NUCLEAR VALOSIN-CONTAINING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02933">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02359">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01073">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CDC48 N-terminal subdomain" evidence="6">
        <location>
            <begin position="11"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="215"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="488"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF82607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="726" mass="79925" checksum="7594F321E1EFC1C1" modified="2014-10-29" version="1">MITIMKKNPLSLKILEAYTRDVGRGVARIDYEALESLNASAGDIIEIAGGKRLIVAKCMPLYPSDEGRKVIRIDGLARNNSGVAIGDAVTITKVKAVPAEKVTLAPMESIPEIDERYLTDALDNLPIVKGDKVTVPYFGGRLAFEVISIVPASVPTLSNKRTIFHITAGEKALGGIAHVTYEDIGGLKEEIQKVREMIELPLRHPEIFEKLGIEAPKGVLLYGPPGTGKTLLAKAVANETNAHFLSISGPEIMSKFYGESEARVREIFKEAKDKAPSIIFIDEIDSIAPKREEVMGEVERRVVSQMLSLMDGLETRGKVIVIAATNRQNALDPALRRPGRFDREIEIRVPDKRGRLEILQIHAHNMPLYEDVDLSKVAAVTHGFVGADLEYLCKEAAMKCLRRMLPELDLEDEKISPEDLGRLIITKADFEQSIKDVMPSAMREVFLDSPDVNWKDIGGLEEVKQELQEAVEWPLKYPDLYSTLGYRVPRGIILYGPSGTGKTLLAKAVATESEANFINVRGPELMSKWVGESERGIREIFRRARQASPCIIFFDEIDSIAASRGHEGSNGGGGVVSQILTELDGINELQGVVVVAATNRPDMIDKALLRPGRFDKIVFVPNPDGKTRLSILRIHAKGKDVGPEMNLEQIATLTEGFSGADVSAVVNTAVSIVVQEYLANYPTPAEATKHISEAEITMRHFEEAVKKIRKQREMKPDGKAAMSHYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPA6</accession>
    <name>A0A075MPA6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UDP-N-acetyl-D-mannosamine dehydrogenase</fullName>
            <ecNumber evidence="1">1.1.1.336</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">UDP-ManNAc 6-dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NTE_00968</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>UDP-N-acetyl-alpha-D-mannosamine + 2 NAD(+) + H2O = UDP-N-acetyl-alpha-D-mannosaminouronate + 2 NADH + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:25780"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:68623"/>
            <dbReference type="ChEBI" id="CHEBI:70731"/>
            <dbReference type="EC" id="1.1.1.336"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.336" evidence="1"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699889.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPA6"/>
    <dbReference type="STRING" id="1459636.NTE_00968"/>
    <dbReference type="GeneID" id="41596798"/>
    <dbReference type="KEGG" id="nev:NTE_00968"/>
    <dbReference type="eggNOG" id="arCOG00252">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023810_3_2_2"/>
    <dbReference type="OrthoDB" id="372050at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089714">
        <property type="term" value="F:UDP-N-acetyl-D-mannosamine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028359">
        <property type="entry name" value="UDP_ManNAc/GlcNAc_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43491">
        <property type="entry name" value="UDP-N-ACETYL-D-MANNOSAMINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43491:SF5">
        <property type="entry name" value="UDP-N-ACETYL-D-MANNOSAMINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500136">
        <property type="entry name" value="UDP_ManNAc_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="UDP-glucose/GDP-mannose dehydrogenase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDP-glucose/GDP-mannose dehydrogenase C-terminal" evidence="9">
        <location>
            <begin position="353"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIF83043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="468" mass="49974" checksum="07DED794695E3C35" modified="2014-10-29" version="1">MKKKKTSNTSKSSSNNSGSAISSLAGKIKSGNVKIAVYGLGHVGSPIASVWLRFGAHVIGVDKSPSVLESARKGKTHVPEPGVNEAFAKGLKQKRFFVYDDPVKASQDSQVKMICVPVLTVGQSLSADLGAVKQVASSVGKGLKKGDLVVLNPSVPPGTSEDVVIPILEKENSGGLKAERDFFMVYSPERIYEGRAIEDIEERYPAIVSGAGPKSVEAGSKLFSLVFKRGVITMTNMRTAEAEKLLEGVYRDVNIALANEMARFCEKVGVDFWEAREGANSQPFCHIHKPGVGVGGACIPVYPQFILHTADIAKAECNITRLGRNVNDSMPAYCVSQALGLLDGIAPAQCKVAVLGLAFRGGVSDTRLSPTYRVIDELKNASVAEIRVHDPMVKSDPALAADIKLTQDLRAALKGADLVLLATDHKEYQKLSKRDTGDAAVYDGRGMLDGTKFAGRFASIGRKKEVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPP1</accession>
    <name>A0A075MPP1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Putative [LysW]-L-2-aminoadipate/[LysW]-L-glutamate phosphate reductase</fullName>
            <ecNumber evidence="7">1.2.1.103</ecNumber>
            <ecNumber evidence="7">1.2.1.106</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">lysY</name>
        <name evidence="9" type="ORF">NTE_00734</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in both the arginine and lysine biosynthetic pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[amino-group carrier protein]-C-terminal-N-(1-carboxy-5-oxopentan-1-yl)-L-glutamine + phosphate + NADP(+) = [amino-group carrier protein]-C-terminal-N-(1-carboxy-5-phosphooxy-5-oxopentan-1-yl)-L-glutamine + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9712"/>
            <dbReference type="Rhea" id="RHEA-COMP:9714"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78499"/>
            <dbReference type="ChEBI" id="CHEBI:78501"/>
            <dbReference type="EC" id="1.2.1.103"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[amino-group carrier protein]-C-terminal-gamma-(L-glutamyl-5-semialdehyde)-L-glutamate + phosphate + NADP(+) = [amino-group carrier protein]-C-terminal-gamma-(5-phospho-L-glutamyl)-L-glutamate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52668"/>
            <dbReference type="Rhea" id="RHEA-COMP:13313"/>
            <dbReference type="Rhea" id="RHEA-COMP:13327"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:136717"/>
            <dbReference type="ChEBI" id="CHEBI:136761"/>
            <dbReference type="EC" id="1.2.1.106"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-arginine biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (Thermus route): step 3/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.103" evidence="7"/>
    <dbReference type="EC" id="1.2.1.106" evidence="7"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699710.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPP1"/>
    <dbReference type="STRING" id="1459636.NTE_00734"/>
    <dbReference type="GeneID" id="41596586"/>
    <dbReference type="KEGG" id="nev:NTE_00734"/>
    <dbReference type="eggNOG" id="arCOG00495">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006384_0_1_2"/>
    <dbReference type="OrthoDB" id="372053at2157"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER00037"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043870">
        <property type="term" value="F:N-acetyl-gamma-aminoadipyl-phosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003942">
        <property type="term" value="F:N-acetyl-gamma-glutamyl-phosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070401">
        <property type="term" value="F:NADP+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:L-arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23939">
        <property type="entry name" value="AGPR_1_C_LysY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17895">
        <property type="entry name" value="AGPR_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00150">
        <property type="entry name" value="ArgC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02083">
        <property type="entry name" value="LysY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050085">
        <property type="entry name" value="AGPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058924">
        <property type="entry name" value="AGPR_dimerisation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000706">
        <property type="entry name" value="AGPR_type-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037535">
        <property type="entry name" value="LysY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01850">
        <property type="entry name" value="argC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32338:SF11">
        <property type="entry name" value="[LYSW]-L-2-AMINOADIPATE_[LYSW]-L-GLUTAMATE PHOSPHATE REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32338">
        <property type="entry name" value="N-ACETYL-GAMMA-GLUTAMYL-PHOSPHATE REDUCTASE, CHLOROPLASTIC-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22698">
        <property type="entry name" value="Semialdhyde_dhC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 7" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="4 7" id="KW-0521">NADP</keyword>
    <keyword evidence="5 7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Semialdehyde dehydrogenase NAD-binding" evidence="8">
        <location>
            <begin position="2"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="9"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF82812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="350" mass="39166" checksum="88B8D83B9FCAAF06" modified="2014-10-29" version="1">MKVGVVGASGYVGGELLRLLVTHPKVEVSMVTSRQKAGEYVQRVHPSLKGFIDLTFSPMDMEKLANNCDMVFTSVPHGKANKIVKDLYDRGIKIIDLSADFRLKNPKDYIKWYGWEHPFPDMLSKSVYGVPELHREEIKKAQLVSCPGCMAVTSLLALKPLIENNLIDTEHVVVDSKIGSSGAGQKANAGTHHAMRYGVVRPYKPAKHRHTGEIEQELSMIAKKQIKVSMSPHAVNIVRGILTTNHTFLKRKVEELELWKMYRNSYKGEPFVRLIRDKKGLYKFPDPKFVVGSNFCDVGFDIDEDNQRIVALSASDNLMKGAAGSAVQVMNVMFGYEETEGLKYTPLTPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPP7</accession>
    <name>A0A075MPP7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01472</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700292.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPP7"/>
    <dbReference type="STRING" id="1459636.NTE_01472"/>
    <dbReference type="GeneID" id="41597265"/>
    <dbReference type="KEGG" id="nev:NTE_01472"/>
    <dbReference type="HOGENOM" id="CLU_1801612_0_0_2"/>
    <dbReference type="OrthoDB" id="11363at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="143" mass="15659" checksum="079023ABBBE1FEE1" modified="2014-10-29" version="1">MHKNNVRRRGKLESNLAETVRIASIVQKGVESGRSSYVEMRALARLTSQNVRAKVHKIQAGLGKDDGLNALLKDVATGMSEGYADVLTPNGIIRDDRLDTLLSLDSDIVTCLGIIAKDRQKEAEDVLMGLVEERKKFVAALKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQ69</accession>
    <name>A0A075MQ69_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Myo-inositol-1-phosphate synthase</fullName>
            <ecNumber evidence="3">5.5.1.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_01645</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the myo-inositol 1-phosphate synthase family.</text>
    </comment>
    <dbReference type="EC" id="5.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700429.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQ69"/>
    <dbReference type="STRING" id="1459636.NTE_01645"/>
    <dbReference type="GeneID" id="41597420"/>
    <dbReference type="KEGG" id="nev:NTE_01645"/>
    <dbReference type="eggNOG" id="arCOG04213">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050011_0_0_2"/>
    <dbReference type="OrthoDB" id="80661at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004512">
        <property type="term" value="F:inositol-3-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006021">
        <property type="term" value="P:inositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052199">
        <property type="entry name" value="MIPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002587">
        <property type="entry name" value="Myo-inos-1-P_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013021">
        <property type="entry name" value="Myo-inos-1-P_Synthase_GAPDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43125">
        <property type="entry name" value="INOSITOL-3-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43125:SF1">
        <property type="entry name" value="INOSITOL-3-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01658">
        <property type="entry name" value="Inos-1-P_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015578">
        <property type="entry name" value="Myoinos-ppht_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myo-inositol-1-phosphate synthase GAPDH-like" evidence="2">
        <location>
            <begin position="197"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF83706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="362" mass="39508" checksum="D947A3E064AF098F" modified="2014-10-29" version="1">MRRKVKVAVAGIGNCASALVQGTRYYRENPDAKKQESDWIGLTAYNLGGLEPSDIEFVAAFDVNASKVGKDLSEAIFAKPNNTIRIIKEMDKMDVKVQKGEVHDGIGRHLAQKIKVADGPAANVVQVLKDTGAEMLLNYLPVGSRRGTQYYAEACLDAGCAFVNAIPVFIASTPKWQDAFAGRGLACAGDDVMSQLGATVVHKTLVKLFVDRGVKVNETYQLNIGGDMDFYNMLDEERLEDKRISKTSAVAAMAPYEVPMRIGPSDFVGFLENDKICYISIKGQYFGGIPVELDLKLKVVDAYNSAGVMIDAARCAKIAIDRGISGPLDSISAYCFKHPPVQMPYSVAKANFLEFVEGKRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQ81</accession>
    <name>A0A075MQ81_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01152</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700022.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQ81"/>
    <dbReference type="GeneID" id="41596964"/>
    <dbReference type="KEGG" id="nev:NTE_01152"/>
    <dbReference type="HOGENOM" id="CLU_2152489_0_0_2"/>
    <dbReference type="OrthoDB" id="380800at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="111" mass="13475" checksum="55BF16B4A42034C8" modified="2014-10-29" version="1">MKKNLTHIRFVKHNRVYYQKQAKRAEAVKLLLEFFSRIEGKVKGMRGYAIMDGIEDQEYESIILTFWENKEDMDTFYKPDNKLLTDLVERLKPLFEQMPRRESYSMIEFKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQ91</accession>
    <name>A0A075MQ91_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Arginase family hydrolase, arginase/agmainase/formiminoglutamate hydrolase</fullName>
            <ecNumber evidence="5">3.5.3.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_00977</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the arginase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.1" evidence="5"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699895.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQ91"/>
    <dbReference type="STRING" id="1459636.NTE_00977"/>
    <dbReference type="GeneID" id="41596806"/>
    <dbReference type="KEGG" id="nev:NTE_00977"/>
    <dbReference type="eggNOG" id="arCOG01700">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039478_6_2_2"/>
    <dbReference type="OrthoDB" id="9706at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004053">
        <property type="term" value="F:arginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09999">
        <property type="entry name" value="Arginase-like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43782">
        <property type="entry name" value="ARGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43782:SF3">
        <property type="entry name" value="ARGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF83052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="301" mass="32498" checksum="4A99723B0669E830" modified="2014-10-29" version="1">MELLQVPKFVVIEAPSILGLKPTGVERLPDALKAANLLGELGAEHAGRVEAPPYSPERDKTTLLLNPQAIHSYSLRLADAVASALQKNQFPLVLGGDCSILIGNALALRRLGKYGLFFIDGHADFYQPEASPTGEVADMDLAIVSGRGPDVLTNIDGLKPLVQDRNIVLFGYRDTKEAAGYGSQDVRESDIYVLDFIEVRKSGVAKAASNALDRLLLCKELKGIWVHLDVDVLDDAVMPAVDYRMKDGGGLNFTELGEILKVLFKSGRVVGMDITIFNPNLDRDGSIARKLVSSIVTGLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQJ2</accession>
    <name>A0A075MQJ2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NTE_01424</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQJ2"/>
    <dbReference type="STRING" id="1459636.NTE_01424"/>
    <dbReference type="KEGG" id="nev:NTE_01424"/>
    <dbReference type="eggNOG" id="arCOG04548">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG08753">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1324058_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050572">
        <property type="entry name" value="Fe-S_Ferredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43687">
        <property type="entry name" value="ADENYLYLSULFATE REDUCTASE, BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43687:SF6">
        <property type="entry name" value="L-ASPARTATE SEMIALDEHYDE SULFURTRANSFERASE IRON-SULFUR SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="9">
        <location>
            <begin position="147"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="9">
        <location>
            <begin position="184"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="51"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIF83488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="216" mass="22318" checksum="6AC7BF5DC3B6FD6D" modified="2014-10-29" version="1">MSTAATTTVAEYVCADCGTLLTHSNPNTLQSMKEVHDQLCVVKRQKTRVAQMAAPAAPKPAAAGPAAAAAPKPSAAPQPAMPAPAAPAAGGSGDTTISLTGSGTSYSKVEGPIDTGFKSKRQVAGQFKGINVWGPLDAPGQLGIWGTNVCVDFDICVADGACIEACPVNVYEWLETPGHPASEKKAFMAREKDCIFCLACENVCPPQAIKIFQKGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQJ5</accession>
    <name>A0A075MQJ5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_01286</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700140.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQJ5"/>
    <dbReference type="STRING" id="1459636.NTE_01286"/>
    <dbReference type="GeneID" id="41597089"/>
    <dbReference type="KEGG" id="nev:NTE_01286"/>
    <dbReference type="eggNOG" id="arCOG01586">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_907939_0_0_2"/>
    <dbReference type="OrthoDB" id="6995at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0043200">
        <property type="term" value="P:response to amino acid"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30154">
        <property type="entry name" value="LEUCINE-RESPONSIVE REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30154:SF34">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR AZLB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13412">
        <property type="entry name" value="HTH_24"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="7"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="148"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF83355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="306" mass="34696" checksum="69E751219BC03956" modified="2014-10-29" version="1">MAKAPTFDKTDIDIIRMLLRDCRVSYRSIGSSVGLSKNAAKTRVDKMVSTGVISAFVMSVNPAVFGYHKICHLIIRDSKTMEETLNRLRLLGEPLTKLDCVGGISLIIVAIKEREEERISLLAGALKPAIVKSCIVGQYPPVRQELRETDFKILKCLMASPRMGVSEIAKRVSISSKTVSSRLLKMKENRILDFRIYTDPTKMQGYVRFGMVIRLEGKNSQKTSRQIHEELEKNFVMAFPMVIQQDVVTWQLIARSMFDIDPALKRIELLDGVKGVEVFIPFRADTYQDWMLKEIDSRIKHAKGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQR3</accession>
    <name>A0A075MQR3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ferredoxin subunit of nitrite reductase and ring-hydroxylating dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NTE_01129</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700012.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQR3"/>
    <dbReference type="STRING" id="1459636.NTE_01129"/>
    <dbReference type="GeneID" id="41596943"/>
    <dbReference type="KEGG" id="nev:NTE_01129"/>
    <dbReference type="eggNOG" id="arCOG02852">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055690_5_0_2"/>
    <dbReference type="OrthoDB" id="35401at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21496">
        <property type="entry name" value="FERREDOXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21496:SF0">
        <property type="entry name" value="RIESKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
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    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="6">
        <location>
            <begin position="9"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF83202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="119" mass="12464" checksum="424A6E25640CE264" modified="2014-10-29" version="1">MAGEARGFQKVANKGDLKEGGLLGVEVEGNKIVLALVEGKVYAMDAVCSHEGGPLEEGELMGHDLKCPWHYALFDVRSGKVSDATVWATDQKSYPVQVDQSTGDILVNLGGGAATTSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQR9</accession>
    <name>A0A075MQR9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01367</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQR9"/>
    <dbReference type="STRING" id="1459636.NTE_01367"/>
    <dbReference type="KEGG" id="nev:NTE_01367"/>
    <dbReference type="eggNOG" id="arCOG14321">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_189619_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="83" mass="9222" checksum="4D126869A56E7820" modified="2014-10-29" version="1">METYVVNYVRNNVKGSTKEKVGGEQITIDFGNRKICNQNFSKLVALPKGALANCGKNARYVNVKLVQMGTEQFLKLTPVQEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQY3</accession>
    <name>A0A075MQY3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01451</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQY3"/>
    <dbReference type="KEGG" id="nev:NTE_01451"/>
    <dbReference type="eggNOG" id="ENOG502N5BC">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_199456_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="75" mass="8609" checksum="1CD838EA1462F02B" modified="2014-10-29" version="1">MYNLFASRSFILPGRVLTMKNKMMMNCLQCHHTYQAHEKNSPRASSILRVGKCLVPGCDCTQYVDKIETIDEDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQZ2</accession>
    <name>A0A075MQZ2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01461</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385209.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQZ2"/>
    <dbReference type="GeneID" id="43502606"/>
    <dbReference type="KEGG" id="nev:NTE_01461"/>
    <dbReference type="HOGENOM" id="CLU_3094240_0_0_2"/>
    <dbReference type="OrthoDB" id="8258at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="51" mass="5749" checksum="4C23D792C6B79924" modified="2014-10-29" version="1">MRTEEEAKYDLDERIFELYDSGMSIQSITEELGTTADYIASVLQNVSVETG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MR00</accession>
    <name>A0A075MR00_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700371.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MR00"/>
    <dbReference type="GeneID" id="41597355"/>
    <dbReference type="KEGG" id="nev:NTE_01575"/>
    <dbReference type="eggNOG" id="arCOG08633">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2103624_0_0_2"/>
    <dbReference type="OrthoDB" id="8779at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="127" mass="14071" checksum="23312D07FD8D6C6C" modified="2014-10-29" version="1">MTNEVTISLAEKEVVAGQELHGTVTINYAGRWDSVVINSQIENSGDVFSYSLLNGKKIKHPYARLSIFKDELKGRTVVEFVSSTNHVPAAGKDHTNVKFRVSLIQEHKEIFSDIAYIKVVAGKLLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MR02</accession>
    <name>A0A075MR02_9ARCH</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01169</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700039.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MR02"/>
    <dbReference type="STRING" id="1459636.NTE_01169"/>
    <dbReference type="GeneID" id="41596981"/>
    <dbReference type="KEGG" id="nev:NTE_01169"/>
    <dbReference type="HOGENOM" id="CLU_1954555_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="128" mass="14951" checksum="5CAEF73B73FA4978" modified="2014-10-29" version="1">MIDNEKDVVKSSPVIWRAFRDYESVLSDDFANAYPELASKIQDAKGAFQTGRTMTDGPYIYWYRIVYAKDGRILTFVNRKQKADRKQDFKNETLTCLHAIVKNTTLQTELLKRIDEKLAPVRDHYERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MR21</accession>
    <name>A0A075MR21_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700385.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MR21"/>
    <dbReference type="STRING" id="1459636.NTE_01590"/>
    <dbReference type="GeneID" id="41597370"/>
    <dbReference type="KEGG" id="nev:NTE_01590"/>
    <dbReference type="eggNOG" id="arCOG02527">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033612_0_0_2"/>
    <dbReference type="OrthoDB" id="2272at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="Sialidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="410" mass="45399" checksum="5412801080E45F15" modified="2014-10-29" version="1">MDFGEIIGISNDSSFYATSPFVAFSYKSNSLYVIWQKTRGIYGNVEHIKGQKNSASIVYRISKDNGRTFGGVITLHDFKEPRSFPPQVAFSPLNENRVFLAWVDKSSPKKLDVYFTRNSESSDRFEEPIIVSDEMTGVCSSEGSNDLRNFGPSRPSETYDTVTPYIAAGNDNNVYVMWVESTTRKKILEIARLEPQDEETSTSISFGEGEIDKAAKYMEEKMRKSLERAPKYRFSIRVFLRASNDGGRTFGKKISLLDTSIDGQGGPYVISPTELHAIGENVYVIVNPLGRDPDNARVRIFASTDKGQTFQERTGLSKTVSGIGSKIISARAKVAAKQHDSLYLLLEVVSHGDEEKMLLLTPFSSPHVPLIFVKSIDAGRTFSDPIHVGVNGPIRSHSSFAVSPTATACI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MR34</accession>
    <name>A0A075MR34_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700069.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MR34"/>
    <dbReference type="GeneID" id="41597014"/>
    <dbReference type="KEGG" id="nev:NTE_01205"/>
    <dbReference type="HOGENOM" id="CLU_2930027_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="60" mass="6903" checksum="985A83FBD1130C85" modified="2014-10-29" version="1">MYRLKLDKYAITTEQKDSTGDRNALVKLGIKADLLKDLDDKQLAELLAALLYTKMKKEME</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MR50</accession>
    <name>A0A075MR50_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700083.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MR50"/>
    <dbReference type="STRING" id="1459636.NTE_01220"/>
    <dbReference type="GeneID" id="41597028"/>
    <dbReference type="KEGG" id="nev:NTE_01220"/>
    <dbReference type="HOGENOM" id="CLU_2930031_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="60" mass="7409" checksum="96BA7F540BD507EC" modified="2014-10-29" version="1">MVRGIRMGRPRKKKQEKRTFTLTEWERIRREMPSFDEQELKEFFDFPRIVADPKMDSGYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRC9</accession>
    <name>A0A075MRC9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01587</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700382.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRC9"/>
    <dbReference type="STRING" id="1459636.NTE_01587"/>
    <dbReference type="GeneID" id="41597367"/>
    <dbReference type="KEGG" id="nev:NTE_01587"/>
    <dbReference type="HOGENOM" id="CLU_2379504_0_0_2"/>
    <dbReference type="OrthoDB" id="6726at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="95" mass="10693" checksum="581FA66F20841618" modified="2014-10-29" version="1">MESALAPPTRLIEYPNDLSGCDSVEIGSKRLLYMCSNSNISKHFVIVLGYYAGQKEDFVTKDLIEPVDDWSRAAIKEVLARSLAQEYADTQVFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRD5</accession>
    <name>A0A075MRD5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Elongation factor 1-beta</fullName>
            <shortName evidence="6">EF-1-beta</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">aEF-1beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ef1b</name>
        <name evidence="8" type="ORF">NTE_01657</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the EF-1-beta/EF-1-delta family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700437.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRD5"/>
    <dbReference type="STRING" id="1459636.NTE_01657"/>
    <dbReference type="GeneID" id="41597432"/>
    <dbReference type="KEGG" id="nev:NTE_01657"/>
    <dbReference type="eggNOG" id="arCOG01988">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_165896_1_0_2"/>
    <dbReference type="OrthoDB" id="84643at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00292">
        <property type="entry name" value="EF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00043">
        <property type="entry name" value="EF1_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036219">
        <property type="entry name" value="eEF-1beta-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014038">
        <property type="entry name" value="EF1B_bsu/dsu_GNE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribsomal_bS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004542">
        <property type="entry name" value="Transl_elong_EF1B_B_arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00489">
        <property type="entry name" value="aEF-1_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001670">
        <property type="entry name" value="PRK00435.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39647">
        <property type="entry name" value="ELONGATION FACTOR 1-BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39647:SF1">
        <property type="entry name" value="ELONGATION FACTOR 1-BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00736">
        <property type="entry name" value="EF1_GNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00888">
        <property type="entry name" value="EF1_GNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54984">
        <property type="entry name" value="eEF-1beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 8" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translation elongation factor EF1B beta/delta subunit guanine nucleotide exchange" evidence="7">
        <location>
            <begin position="3"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF83718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="93" mass="10019" checksum="700BB11D7E9A6B44" modified="2014-10-29" version="1">MARLVARIKVLPADADISIDKIVEGLKGNIPQGMELKGHAKEPIAFGLNAVVGDFMLDDAEGQMDKLEEAIRSVQGVGEIEVMNISRASVKMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRJ7</accession>
    <name>A0A075MRJ7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700790.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRJ7"/>
    <dbReference type="STRING" id="1459636.NTE_02111"/>
    <dbReference type="GeneID" id="41597841"/>
    <dbReference type="KEGG" id="nev:NTE_02111"/>
    <dbReference type="HOGENOM" id="CLU_376702_0_0_2"/>
    <dbReference type="OrthoDB" id="387765at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="386"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="736" mass="78092" checksum="9DC6ED539FB94D11" modified="2014-10-29" version="1">MSSNPAIVIGVSAVNTADAELKKLDDKVRETTGIVETEGNKMASVTSSTTEKVKKNYLNIAGSVASLGAGLVGFATSFSTLERAQTRSDQATLTYQRSLSRLNDMIAEGGHSADELAQQQEKVRINADKAKQSQDNLNDTYTNFLANIPSQFINFGYSASNIYDMVKKNQQESGETVKESSKVYSGALTLMKEANIKTAASTSFLDSTVKKVFLSNPYILPIIATSAVVTALAFNVGGLRDRTNEFGKAIGDAIPALRPLLDAIGSLQNVFGGATEKSKDLTDTTYDLGDAADATKKHIQTYSEYLADVADKTGDASRQNLYFLQASGQLASGLTLTNDQLALAATYLKDHADDTNKTTQANFDLVASVYGLNTALQLNNGELGNLADALTKAKKAQDAAKNAADDEKEAQRKATEAIQERVKANVELARSMGVQINLHTTTVDQTDRISEHLQSLQSDYETARKNAEDFAIANGVNVVTAVKATDGQLVNIIGTLAQTKAGSADTARSVVQDFLMSKKAVDQYSKSAGDSGLAITALGNTSHDTSAQIKDATAFIDEQSSKTFNNFVIGAQASLLAIAALQDRALVSQFGQVGGIAGTVSTDALTAAGFGNNASLMQSAASGRLGGVFTPGGRVLDTGGTLYEDVIGIGKDTGTPHYLHKNELVIPPSKLGRLSAVRNDVAGHSKPKRGVIFSFKIGDDVIATAKIPDMYAVLEGEYGNDIVINAGDKGWRRRYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRN2</accession>
    <name>A0A075MRN2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator, HxlR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_02147</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRN2"/>
    <dbReference type="STRING" id="1459636.NTE_02147"/>
    <dbReference type="KEGG" id="nev:NTE_02147"/>
    <dbReference type="eggNOG" id="arCOG01057">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111585_5_3_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33204">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR, MARR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33204:SF18">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="4">
        <location>
            <begin position="19"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF84201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="129" mass="14732" checksum="BFB16F67B599CCBA" modified="2014-10-29" version="1">MERRVHMSIVLDKSSGGFAGATGIARVLGKKWALLILENISAREAARFDDLKRALEGISSTVLSERLKELEHESLVVKKIYKRPPKIEYKLSDSARELQSIMDEIGRWQVRWKREKNLLKGGEGKMQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRQ3</accession>
    <name>A0A075MRQ3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription elongation factor Spt4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">spt4</name>
        <name evidence="4" type="ORF">NTE_01704</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Stimulates transcription elongation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer composed of Spt4 and Spt5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the archaeal Spt4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700475.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRQ3"/>
    <dbReference type="STRING" id="1459636.NTE_01704"/>
    <dbReference type="GeneID" id="41597474"/>
    <dbReference type="KEGG" id="nev:NTE_01704"/>
    <dbReference type="eggNOG" id="arCOG04077">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_199467_0_0_2"/>
    <dbReference type="OrthoDB" id="275101at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00949">
        <property type="entry name" value="Spt4_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029040">
        <property type="entry name" value="RPABC4/Spt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022800">
        <property type="entry name" value="Spt4/RpoE2_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007178">
        <property type="entry name" value="Spt4_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038589">
        <property type="entry name" value="Spt4_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041664">
        <property type="entry name" value="RNAP_arch_Epp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40704">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40704:SF1">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06093">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01389">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63393">
        <property type="entry name" value="RNA polymerase subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Spt4/RpoE2 zinc finger" evidence="3">
        <location>
            <begin position="4"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF83765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="62" mass="6741" checksum="711565A862712910" modified="2014-10-29" version="1">MAKEKACRRCKALTSGKVCPVCKSTDLSPDWSGIILVFDPAKSLVANTLEITTPSRYALKVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRQ8</accession>
    <name>A0A075MRQ8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01709</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700479.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRQ8"/>
    <dbReference type="STRING" id="1459636.NTE_01709"/>
    <dbReference type="GeneID" id="41597478"/>
    <dbReference type="KEGG" id="nev:NTE_01709"/>
    <dbReference type="eggNOG" id="arCOG08800">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1598936_0_0_2"/>
    <dbReference type="OrthoDB" id="10393at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="166" mass="17748" checksum="04FDF2C775343306" modified="2014-10-29" version="1">MLLKAAGSIAIAVILAAVLATSSLTNRAYAATISGYSETKVIVKGDQQHCLQVDATKVAGLQFRDFSGNGIKQVAAGSQVSVQAIINSGCDVADYPATVLLEVRDSDGITKYLAFQQIALEPSQWSRISFSWVPDKPGNYDVRTFVMTCIACSGLNPVTMHRISVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRU7</accession>
    <name>A0A075MRU7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Small ribosomal subunit protein uS19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rps19p</name>
        <name evidence="8" type="ORF">NTE_01833</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 7">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_075053869.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRU7"/>
    <dbReference type="STRING" id="1459636.NTE_01833"/>
    <dbReference type="GeneID" id="41597597"/>
    <dbReference type="KEGG" id="nev:NTE_01833"/>
    <dbReference type="eggNOG" id="arCOG04099">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097347_1_0_2"/>
    <dbReference type="OrthoDB" id="30559at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.860.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="entry name" value="30s Ribosomal Protein S19, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00531">
        <property type="entry name" value="Ribosomal_uS19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_uS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020934">
        <property type="entry name" value="Ribosomal_uS19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005713">
        <property type="entry name" value="Ribosomal_uS19_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_uS19_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003121">
        <property type="entry name" value="PRK04038.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01025">
        <property type="entry name" value="uS19_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="RIBOSOMAL PROTEIN S19P FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002144">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="Ribosomal protein S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00323">
        <property type="entry name" value="RIBOSOMAL_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF83893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="135" mass="15354" checksum="BA7691ABF96D8FB4" modified="2014-10-29" version="1">MVREFKFKGYTPEQLQSLSIENLLPLLNARQRRSLDKRVGTYMNDEKRKLREKIKLARDGKLKGAIRTHIRDMIILPDMIGLTINVHNGKEFAAVAIRPEMVGHYLGEYAITNKRVQHGAPGVGASRSSLYVPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRV2</accession>
    <name>A0A075MRV2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator, HxlR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_00055</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699200.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRV2"/>
    <dbReference type="STRING" id="1459636.NTE_00055"/>
    <dbReference type="GeneID" id="41596006"/>
    <dbReference type="KEGG" id="nev:NTE_00055"/>
    <dbReference type="eggNOG" id="arCOG01057">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111585_5_3_2"/>
    <dbReference type="OrthoDB" id="10490at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33204">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR, MARR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33204:SF18">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="4">
        <location>
            <begin position="12"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF82139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="127" mass="14423" checksum="C62087585D2DF754" modified="2014-10-29" version="1">METKKLPVIQDCGFDGYDAASLMSETARLRRIITKRGTLEILIPLCCTVEPVRYKQFRDTIKGVSSKTLATRLKELEKGGILERKAYSEIPPRVEYRLTPKGQELVESVINLLQWMRKWSSSSSSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRV9</accession>
    <name>A0A075MRV9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01769</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700532.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRV9"/>
    <dbReference type="STRING" id="1459636.NTE_01769"/>
    <dbReference type="GeneID" id="41597539"/>
    <dbReference type="KEGG" id="nev:NTE_01769"/>
    <dbReference type="HOGENOM" id="CLU_2893373_0_0_2"/>
    <dbReference type="OrthoDB" id="5675at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="62" mass="6828" checksum="51F32E768BCFAD4C" modified="2014-10-29" version="1">MAETVELEDFDIAFSFRCPKCDYVNEEVSAKDLSSGNAECGMCETVFRVEGLDGIKITANLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MS23</accession>
    <name>A0A075MS23_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02262</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MS23"/>
    <dbReference type="STRING" id="1459636.NTE_02262"/>
    <dbReference type="KEGG" id="nev:NTE_02262"/>
    <dbReference type="HOGENOM" id="CLU_2243947_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="103" mass="11490" checksum="FB20415677FCB9B4" modified="2014-10-29" version="1">MRDLLYMAEAKDRIEFKMLEHESVGDDTVSFKLEDGTIVKVKVSLERVGIATNYRNPDGTPHYAVNSAVKVYIIPADKRFTMPKNQVSGAAAPQERPSPSHIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MS54</accession>
    <name>A0A075MS54_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02313</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MS54"/>
    <dbReference type="STRING" id="1459636.NTE_02313"/>
    <dbReference type="KEGG" id="nev:NTE_02313"/>
    <dbReference type="eggNOG" id="arCOG00250">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_730761_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="406" mass="44108" checksum="7DBC48466C730494" modified="2014-10-29" version="1">MATRIWRVARGSSVYSLSAGSVLPTVAVYGLSTEGYRIASAMAIKGAKVSLIDESLRNAISLKADIARTYPNVSSLVEDEPLLGLEPMDVAIGNASYLFFAPRVRKIGTDVKADVATKFKDAVKALKKGSSVVYMLPSGIGGNNENIALIEHVTGMAADQDVSYYYMPSSPIASGAEVLVGSAKSKQDNNLAKMLYDTDGKKKVSFVDIYSAELSHIIRALSHYSGMASILEVCKKATDGSLPANELMHGTFSDLYIDDVTSGLYDLRIIGSSLDGAGPLMYLVNGSIRGIEGYTKHLIDQVRGTLKKRDLKASRTKVAIAWTLDPHEMRGDKIDLLSSLETKVRDYIGDVERHQGPTFDLYHTDKTTVVITCSKADFDKVVSKNRQSDDFIVIKANPLCETLTQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MS84</accession>
    <name>A0A075MS84_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Roadblock/LAMTOR2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02369</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701000.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MS84"/>
    <dbReference type="STRING" id="1459636.NTE_02369"/>
    <dbReference type="GeneID" id="41598084"/>
    <dbReference type="KEGG" id="nev:NTE_02369"/>
    <dbReference type="eggNOG" id="arCOG08684">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128582_1_0_2"/>
    <dbReference type="OrthoDB" id="375575at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="128" mass="14462" checksum="447232AB44B8691D" modified="2014-10-29" version="1">MASQDRFHEFCEKILALDTAVIFFALVDHIGDIVAMTYRETPFVDEKEAMQYAIQMTIAAILLAHFENRLGRIQYTVTYHDDIARVTLPIVVGNQKFFVLLLLDSGSDVVSVMKNKISPFVMGSKGIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSB3</accession>
    <name>A0A075MSB3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane-associated phospholipid phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_02416</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSB3"/>
    <dbReference type="STRING" id="1459636.NTE_02416"/>
    <dbReference type="KEGG" id="nev:NTE_02416"/>
    <dbReference type="eggNOG" id="arCOG03056">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1100916_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042392">
        <property type="term" value="F:sphingosine-1-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03392">
        <property type="entry name" value="PAP2_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969:SF13">
        <property type="entry name" value="AT30094P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="2">
        <location>
            <begin position="118"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF84466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="252" mass="26950" checksum="CB0E8D91DEEC7D0D" modified="2014-10-29" version="1">MLPRYGNGANCYNPTRSLSNIHIFLNNNDKKYLAVSMMLIASFLVLAALVSPRVNPDSSNSGIAKDDADAFLAVNDSHFSTPFDQFMILLTEYGREAVWIVAGALIFFFGGRAGRKTAVVMTMALLVLIPIGTIAKEIVARPRPIVPQSDFLLAADPDFSFPSGHALIVSAGAATVLVLYRGSGRKMLVSLGLAAEAALVCLSRVYVGGHYPLDVLGGILLGVGVAFIFVGIAGRIEVAMRPVANVLRRNKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSK7</accession>
    <name>A0A075MSK7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02512</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385476.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSK7"/>
    <dbReference type="STRING" id="1459636.NTE_02512"/>
    <dbReference type="GeneID" id="41598216"/>
    <dbReference type="KEGG" id="nev:NTE_02512"/>
    <dbReference type="HOGENOM" id="CLU_1412408_0_0_2"/>
    <dbReference type="OrthoDB" id="11913at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="193" mass="20754" checksum="594CE01294629C47" modified="2014-10-29" version="1">MATTTTAKQAAILGLSAILVTGVAFSALLYGNVAQAQSDNMNMSDRITAAMKDNKRMVATGVLSTMQTGADGAHWLVYGPWRMMVVAQPNGEEGQNPNVTFNASVRMVMTDGNAMHRHTISDFKMSKWSSDDSSITIDGTAMITTRDGPAQVPVTVKILQKQVIVITLDTSVLNHFGETPLYGLVSMVRMLGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSS0</accession>
    <name>A0A075MSS0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01766</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSS0"/>
    <dbReference type="KEGG" id="nev:NTE_01766"/>
    <dbReference type="HOGENOM" id="CLU_2712981_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="72" mass="8414" checksum="34F0F92F7FDD6662" modified="2014-10-29" version="1">MFSVKKLGKNGMWGTVSLIDENGSFRGEARFETREDAEKYLVKFKNRMKKPVDLKVFNDSEAEEPKKKDKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSS1</accession>
    <name>A0A075MSS1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02141</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSS1"/>
    <dbReference type="KEGG" id="nev:NTE_02141"/>
    <dbReference type="HOGENOM" id="CLU_2055955_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="119" mass="13468" checksum="20DB5E209BF038A9" modified="2014-10-29" version="1">MIFITLGSELCAYFSCVYMSVRVCFQRTTNTSVVVDDAVSPFVYAMLFKINRTPSWRSYKIFFLCMSCYLPSDTPATFSCFMTYSTLAAVMLPIVVEVSPVLPRDLIIEFISCDIISES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSS5</accession>
    <name>A0A075MSS5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_02144</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700814.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSS5"/>
    <dbReference type="STRING" id="1459636.NTE_02144"/>
    <dbReference type="GeneID" id="41597869"/>
    <dbReference type="KEGG" id="nev:NTE_02144"/>
    <dbReference type="HOGENOM" id="CLU_1017870_0_0_2"/>
    <dbReference type="OrthoDB" id="1018at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861:SF6">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="2">
        <location>
            <begin position="65"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF84198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="277" mass="31852" checksum="E0916026F4BF750A" modified="2014-10-29" version="1">MKNSETRGYWEERLAKNFDLSGVGFSSLGKNYNRWMYRVRRHVLLKTLGKLDYDYHRHLGRTTKILDIGVGTGFYIDFWKKLYQGKAAAVDGVDITAVAVERMKKKYPDSQFYVADIGESNVLEMFGKKTYNIISAFDVLFHITNDEKYKRAIQNIYSLLEPAGIFVLSENFVHSNLSRAEFQVNRSKEHIERLLEDTGFQIIERTPMFVLMNAPVNSDSKMRKRCWRVLTRLVSQGESMGFAVGAATYPIECLLLSVTDKGPSTELIICKKAQEQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSX6</accession>
    <name>A0A075MSX6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rps13</name>
        <name evidence="6" type="ORF">NTE_02226</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSX6"/>
    <dbReference type="STRING" id="1459636.NTE_02226"/>
    <dbReference type="KEGG" id="nev:NTE_02226"/>
    <dbReference type="eggNOG" id="arCOG01722">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103849_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.50:FF:000001">
        <property type="entry name" value="30S ribosomal protein S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="entry name" value="30s ribosomal protein s13, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01315">
        <property type="entry name" value="Ribosomal_uS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="Rbsml_uS13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_uS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_uS13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018269">
        <property type="entry name" value="Ribosomal_uS13_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003140">
        <property type="entry name" value="PRK04053.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S13/40S RIBOSOMAL PROTEIN S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="S13-like H2TH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00646">
        <property type="entry name" value="RIBOSOMAL_S13_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="199"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF84280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="256" mass="26887" checksum="93163AD43C8B17D3" modified="2014-10-29" version="1">MPLNFNKEYGQTGAAAICCKYCIVFVPARLAWFLLPNVRREYDLSASEYKHILRIAGKDVEGSKKLLVAISEIKGVGYNFAQVLTQSLNVNPNMRVGFLTEKELREIEEAISNPTKFGVPEWYLNRKKDMDSGATHHLITSDLDFAIGNDVDREKTVMSWRGYRHMFGLRVRGQRTRTTGRKGGAVGVKKTKMVPGAAPAAAGAAPAGGAAAPAAAKPAAGAAAPAAGAAKPAAGGGAAAPAAAKPAAGAKEPAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MT07</accession>
    <name>A0A075MT07_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PPOX class probable F420-dependent enzyme, MSMEG_5819 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_02282</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700929.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MT07"/>
    <dbReference type="STRING" id="1459636.NTE_02282"/>
    <dbReference type="GeneID" id="41597997"/>
    <dbReference type="KEGG" id="nev:NTE_02282"/>
    <dbReference type="HOGENOM" id="CLU_125990_0_0_2"/>
    <dbReference type="OrthoDB" id="8977at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070967">
        <property type="term" value="F:coenzyme F420 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052019">
        <property type="entry name" value="F420H2_bilvrd_red/Heme_oxyg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024031">
        <property type="entry name" value="MSMEG_5819/OxyR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04023">
        <property type="entry name" value="PPOX_MSMEG_5819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35176">
        <property type="entry name" value="HEME OXYGENASE HI_0854-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35176:SF6">
        <property type="entry name" value="HEME OXYGENASE HI_0854-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="PNPOx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine 5'-phosphate oxidase N-terminal" evidence="2">
        <location>
            <begin position="9"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF84335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="136" mass="15246" checksum="D94E1434A2544312" modified="2014-10-29" version="1">MSYSEPEVQYLKSQRLARIATASPEGRPDVAPVAFEFDGKYFYAGSHSQDIFHKTRKYKNVRDGNKRVALAIDDLESVNPWKPRGIKVYGTAEIVEHDGMFGRGNYLRIAPSISWSWGIKEGIKTVKTVHGNSSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MT35</accession>
    <name>A0A075MT35_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Roadblock/LAMTOR2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00402</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699445.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MT35"/>
    <dbReference type="STRING" id="1459636.NTE_00402"/>
    <dbReference type="GeneID" id="41596283"/>
    <dbReference type="KEGG" id="nev:NTE_00402"/>
    <dbReference type="eggNOG" id="arCOG08684">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_157016_0_0_2"/>
    <dbReference type="OrthoDB" id="373551at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="124" mass="14495" checksum="4B8D608E43007EE2" modified="2014-10-29" version="1">MQQQKEICHAIARLHENILAVFFVQDGAIVEWRARPGIRMPGSHEMEGVMMQRFIMMSLAKNHETFLGRLHYVAGRYDDSDVLLFDHGRDEKSMLVVRVKRPYRMEVLAKKVSGILRSRKENLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MT48</accession>
    <name>A0A075MT48_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02678</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MT48"/>
    <dbReference type="STRING" id="1459636.NTE_02678"/>
    <dbReference type="KEGG" id="nev:NTE_02678"/>
    <dbReference type="eggNOG" id="arCOG08127">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2313874_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058349">
        <property type="entry name" value="DUF8036"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26119">
        <property type="entry name" value="DUF8036"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="96" mass="10223" checksum="6DFCAB17D7A0E23B" modified="2014-10-29" version="1">MLGAAGAALLNIGLLGGIVALYIQSLRVIKSYFTWGLVIVASLFIVQNIVIVIFWSNLYLAGPSIKAIVDAAAPYLFAINAAQSGGLAVLFWITRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MT70</accession>
    <name>A0A075MT70_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02704</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_075054524.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MT70"/>
    <dbReference type="STRING" id="1459636.NTE_02704"/>
    <dbReference type="GeneID" id="41598393"/>
    <dbReference type="KEGG" id="nev:NTE_02704"/>
    <dbReference type="eggNOG" id="arCOG08662">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_182705_1_0_2"/>
    <dbReference type="OrthoDB" id="5605at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="80" mass="9183" checksum="E8B56BA52C348F7F" modified="2014-10-29" version="1">MTCKGICIRHKAQKPVGSGRYASGQKRCQICEIFIKWDGLWCPCCGYRLRTKPRNLKYKAKLRARAKKMAVAKPIAVRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTB6</accession>
    <name>A0A075MTB6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphopantetheine adenylyltransferase</fullName>
            <ecNumber evidence="1">2.7.7.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.3" evidence="1"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700942.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTB6"/>
    <dbReference type="STRING" id="1459636.NTE_02305"/>
    <dbReference type="GeneID" id="41598020"/>
    <dbReference type="KEGG" id="nev:NTE_02305"/>
    <dbReference type="eggNOG" id="arCOG00972">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1363593_0_0_2"/>
    <dbReference type="OrthoDB" id="7814at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004595">
        <property type="term" value="F:pantetheine-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="204" mass="23842" checksum="469D4D69BE6D3A3A" modified="2014-10-29" version="1">MGRTAVLYLAHLNPVTKAHESIISSLLERDYSVYVFPVRFIKDNREINTKSFPFSFEQRKEMVEALFGNSVTVLPDYTFYAPFAKYLPPLLSSKSWELRNQIVSHVKEGKFVSYTGDKAERLMLKIYRLNPLKADRLEISATSVKEMLYREAREGDRGEWRQMVPPQVVDAIERNWSVVEKFAREQDDATMRVMGMKFPREGYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTL1</accession>
    <name>A0A075MTL1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02408</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701030.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTL1"/>
    <dbReference type="GeneID" id="41598119"/>
    <dbReference type="KEGG" id="nev:NTE_02408"/>
    <dbReference type="eggNOG" id="arCOG08080">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2204002_0_0_2"/>
    <dbReference type="OrthoDB" id="8393at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="107" mass="12184" checksum="14B4D586AB4C4ADD" modified="2014-10-29" version="1">MDDSARFRITQMTDTGTNVTLALAEDVELETVSQQQMMIEAIDRAVMDKEVKEQIKPVLEAILRAQPQTVVRSYSQTMIQITMPKRRYEKIGSPRVGERVTVDISRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTV2</accession>
    <name>A0A075MTV2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF899 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03031</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTV2"/>
    <dbReference type="STRING" id="1459636.NTE_03031"/>
    <dbReference type="KEGG" id="nev:NTE_03031"/>
    <dbReference type="HOGENOM" id="CLU_066898_2_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010296">
        <property type="entry name" value="DUF899_thioredox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05988">
        <property type="entry name" value="DUF899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="266" mass="30137" checksum="4956254F5ED7E980" modified="2014-10-29" version="1">MAHSAARAAQGGEGANAAQRRQALPWVRVDKEYRFETDEGSASLADLFRGRSQLLVYHFMFGPDYAAGCPSCSAIADGFNGFAMHLANHDVMLWAVSRAPLAKLQAYRRRMGWTFPWASSFGSDFNFDFNVWFTEEQQREGGIEYNYQREEAWQWREGQESGGEGPVAQIAAMAGTDVATYIRERPGMSAFALEDDVVYHTYSTYARGLDCLWGMYQWLDRAPQGAQRDGHLVAPPRRVQGLSDVVAQLWDWRRRTQADMIISCHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MU14</accession>
    <name>A0A075MU14_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AAA family ATPase, CDC48 subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NTE_02605</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. CDC48 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701181.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MU14"/>
    <dbReference type="STRING" id="1459636.NTE_02605"/>
    <dbReference type="GeneID" id="41598298"/>
    <dbReference type="KEGG" id="nev:NTE_02605"/>
    <dbReference type="eggNOG" id="arCOG01308">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_12_2_2"/>
    <dbReference type="OrthoDB" id="77269at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19529">
        <property type="entry name" value="RecA-like_VCP_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000007">
        <property type="entry name" value="AAA family ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000057">
        <property type="entry name" value="AAA family ATPase, CDC48 subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000018">
        <property type="entry name" value="Cell division control 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000105">
        <property type="entry name" value="PeRoXisome assembly factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000012">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005938">
        <property type="entry name" value="AAA_ATPase_CDC48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004201">
        <property type="entry name" value="Cdc48_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003338">
        <property type="entry name" value="CDC4_N-term_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01243">
        <property type="entry name" value="CDC48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF171">
        <property type="entry name" value="NUCLEAR VALOSIN-CONTAINING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02933">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02359">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01072">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01073">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CDC48 N-terminal subdomain" evidence="7">
        <location>
            <begin position="9"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="CDC48" evidence="6">
        <location>
            <begin position="111"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="221"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="494"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF84648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="747" mass="81444" checksum="86B71C10E1AB0493" modified="2014-10-29" version="1">MSSSDNKASLRVAEADARDVGRRIARIDPKVAARLGITTGDAVEVISPASKRKTTVLNWPAYQKDNGKELIRIDGYARNKLGIGIGDTVDVRKVEAKPAQSVALAPTEPLRILGAEDYLAGFLQGQLVTKGDTIPLGIMGQRVDLVVISTNPSGPVIIEPSTEVSISEESAKAAAAAKEAGIPAITYEDIGGLRGEVTKVREMIELPLRHPELFRRLGVEAPKGVILHGPPGTGKTLLAKAVANETQANFYSIGGPEIMSKYYGESEERLRNIFEEAQKNAPSIIFIDELDSIAPKREEVSGEVERRVVAQLLSLMDGLTARGKVVVIGATNRINAIDPALRRPGRFDREIEIGVPDRNGRLEVLQIHTRGMPLDKDVNLEKLADISHGFVGADLQALAKEAAMRALRRVLPEIDVSAESIPGEILNKIIVKMQDFMDVVKEMEPSAMREVFVEIPDVQWADVGGLQDVKQELREAVEWPLKYQGLFAYSDATPPKGILLYGPPGTGKTLLAKAAANESEANFISIKGPELLSKWVGESEKGVREIFRKARQAAPCIIFFDEIDAIAPTRGGDFGDSHVTERVISQMLTELDGLEILTNVVVIAATNRPDIVDPALLRPGRFDRLLYVPPPDKESRLQILKIHTKKKPLDKDVNIEQLAGDMNGYTGADIASVASAAVMLALREHVAKYSDAKEAESHAKDLKVKMRHFKEAMTKVRPLSSQELDMYKNIAEKFGMPSRVTGAAYAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MU26</accession>
    <name>A0A075MU26_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methyltransferase domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00709</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699690.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MU26"/>
    <dbReference type="STRING" id="1459636.NTE_00709"/>
    <dbReference type="GeneID" id="41596563"/>
    <dbReference type="KEGG" id="nev:NTE_00709"/>
    <dbReference type="HOGENOM" id="CLU_1536583_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="174" mass="19567" checksum="3A914C0216F1B982" modified="2014-10-29" version="1">MFLFGPKAFYKKYVADGNVYPLNHELVNTIMSFEPSSVFEFGCGVGKNLVLLRDKGVKSIFGIDISEAAIKKAKEKGINALRADERHLSKVQPCDVAFTCSVLDHVENIDKIMEQLKRIAQKAVVLMETNDTPAKFYYPHDYESYGFVKTGYAYQSRLPEGDGALYNLYVFKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUA4</accession>
    <name>A0A075MUA4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Nicotinamide-nucleotide adenylyltransferase</fullName>
            <ecNumber evidence="4 5">2.7.7.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">NAD(+) diphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">NAD(+) pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">NMN adenylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NTE_02718</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>beta-nicotinamide D-ribonucleotide + ATP + H(+) = diphosphate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:21360"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="EC" id="2.7.7.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from nicotinamide D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the archaeal NMN adenylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.1" evidence="4 5"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUA4"/>
    <dbReference type="STRING" id="1459636.NTE_02718"/>
    <dbReference type="KEGG" id="nev:NTE_02718"/>
    <dbReference type="eggNOG" id="arCOG00972">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108783_0_0_2"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000309">
        <property type="term" value="F:nicotinamide-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00243">
        <property type="entry name" value="NMN_adenylyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006418">
        <property type="entry name" value="NMN_Atrans_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01527">
        <property type="entry name" value="arch_NMN_Atrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002243">
        <property type="entry name" value="PRK01153.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21342:SF0">
        <property type="entry name" value="BIFUNCTIONAL NMN ADENYLYLTRANSFERASE_NUDIX HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21342">
        <property type="entry name" value="PHOSPHOPANTETHEINE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 4 7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="6">
        <location>
            <begin position="8"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="NCBIfam" id="TIGR01527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF84760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="184" mass="20904" checksum="C186612A1C225960" modified="2014-10-29" version="1">MPHMTTGLFVGRFQPFHLGHLATVKFALKSVDDLVIVVGSAQKSHEQRNPFTAGERIAMIRAALKADDGVDMGRIMTIPVPDVDVHSLWTRQVDMLVPAYNIVFVNDPFTLFLFRERGVKTVEPPLQERSRLMATEVRRRMAEGEKWQELVPAAVAKAIEQIDGVERVKAVTQQDYHHHNHNHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUL0</accession>
    <name>A0A075MUL0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02872</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUL0"/>
    <dbReference type="STRING" id="1459636.NTE_02872"/>
    <dbReference type="KEGG" id="nev:NTE_02872"/>
    <dbReference type="eggNOG" id="arCOG07781">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1275265_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="216" mass="21304" checksum="D66E7E44B3405562" modified="2014-10-29" version="1">MCMEGRRTRKKINAAISMTTTTIPAFAVTIALLLIIAAVPAIALPSPAFAATFHISGEASCKALPLSGGNATWNSSEHQCAIPAGSALALSGNSAIAVDSGIVLVNQGAIQNSGGGAINIAAGAKIHNKGTFDNTGKVGGSGSILNDGVLNNAATIAISSPGGIENAKTGILSNSGFIHTGSLANAGTLFNSGVIDSKSHIENSGTIVNGGTIKSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUL2</accession>
    <name>A0A075MUL2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Adenosylhomocysteinase</fullName>
            <ecNumber evidence="4">3.13.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NTE_03322</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="6">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the adenosylhomocysteinase family.</text>
    </comment>
    <dbReference type="EC" id="3.13.2.1" evidence="4"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUL2"/>
    <dbReference type="STRING" id="1459636.NTE_03322"/>
    <dbReference type="KEGG" id="nev:NTE_03322"/>
    <dbReference type="eggNOG" id="arCOG04137">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025194_0_2_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004013">
        <property type="term" value="F:adenosylhomocysteinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033353">
        <property type="term" value="P:S-adenosylmethionine cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00401">
        <property type="entry name" value="SAHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1480">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042172">
        <property type="entry name" value="Adenosylhomocyst_ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000043">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015878">
        <property type="entry name" value="Ado_hCys_hydrolase_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00936">
        <property type="entry name" value="ahcY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004005">
        <property type="entry name" value="PRK05476.2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420">
        <property type="entry name" value="ADENOSYLHOMOCYSTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420:SF0">
        <property type="entry name" value="ADENOSYLHOMOCYSTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05221">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00670">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001109">
        <property type="entry name" value="Ad_hcy_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00996">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00997">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S-adenosyl-L-homocysteine hydrolase NAD binding" evidence="8">
        <location>
            <begin position="187"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="218"/>
            <end position="223"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="NCBIfam" id="TIGR00936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001109-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF85351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="414" mass="45208" checksum="082A3A7206C457B4" modified="2014-10-29" version="1">MLPGKTRTATIADPDLAQKGRLSHEWARARMSIVEKIVDKNSKNRPLEGFTIGFCLHVTKETSVLVMAAKRLGAKVALCSANPLSVQDDIAVFLQQEGARVFAWRGETAQEYRDCIRQVLALSPQIITDDGSDMHTAAHRAKTKGIVGGTEETTSGVRRLLALEKSGRLMYPIIAVNNARTKYLFDNRHGTGQSTLDGIMRATGMFLPGARVVVCGYGWVGKGVAAKARGMGAVVTVTEVDPVRALEARMDGFEVTTLLNAAPYGDLFITCTGQTSVIRKEHFAKMKDGAILANTGHFDVEIDASYLYSNAKPEEIRPGVERFSIAGKKLYLLSKGRVVNLVAAEGHPPEVMALSFANQLMSILHVAKNHAKMEEKVYSVPEDIDVQVAKSALDAMGVRIDEMTEEQKKYQNSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUM2</accession>
    <name>A0A075MUM2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Methyl-accepting chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NTE_02340</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700973.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUM2"/>
    <dbReference type="STRING" id="1459636.NTE_02340"/>
    <dbReference type="GeneID" id="41598056"/>
    <dbReference type="KEGG" id="nev:NTE_02340"/>
    <dbReference type="eggNOG" id="arCOG02344">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_107_19_2"/>
    <dbReference type="OrthoDB" id="2830at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06225">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11386">
        <property type="entry name" value="MCP_signal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.500">
        <property type="entry name" value="HAMP domain in histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.950">
        <property type="entry name" value="Methyl-accepting chemotaxis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004090">
        <property type="entry name" value="Chemotax_Me-accpt_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32089:SF112">
        <property type="entry name" value="LYSOZYME-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32089">
        <property type="entry name" value="METHYL-ACCEPTING CHEMOTAXIS PROTEIN MCPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00260">
        <property type="entry name" value="CHEMTRNSDUCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58104">
        <property type="entry name" value="Methyl-accepting chemotaxis protein (MCP) signaling domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0807">Transducer</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="7">
        <location>
            <begin position="326"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="6">
        <location>
            <begin position="398"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="685"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="700"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF84392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="759" mass="80661" checksum="929A68F15528065D" modified="2014-10-29" version="1">MKNPLSHSLNGRLISLFVAMSVVPLVAIAMLSFNAAQGALSNKISNELHSLAVSRAEAVEILNEMRVQQASTFAAGEKVQDLFQLYNAKEAGTGVDESQLKEASNTLLGEFSEFKEATGGNDGFYKIKMVSMKGTVFFSSDSSEVGKNLAQDATFQKAKQQPVSFVEYDADKKEGARTVLVPVTAHGGQDVIGVVYTSVPTHVASQILLNREGLGETGETYLVNSEGLMISESRFVQGAAFNQRVNTLPVTECFEKGTTVNGIYPDYRGIPVYGASACVKEAGMVLLAEYDVAEINAPITQLQNQYLLLGGPIMGAVGVAAFFISRSISRPIAVISKAAQRVSEGNLTVKMGEIRSKDEIGVLSKSFTDMVASIRELVRQAQDNSITISSTAEQMAASTEEVNASINQVSTSVQQIAKGTQDQAKRLEENNRIAEDLRTTMKGVSRSAEEVAGQAMQTGKTAQAGQTAASDAAQRMTKIHDFVSKAVSDIKGISEKSAQIASALGVINTISDKTNLLALNAAIEAARAGEAGKGFAVVADEVKRLAEGSLKASEEIAKLVDEIKTTIEASVQNIESGSKEVYEGTDIINRALSSLEAISTEALQTAKRVQEIASSTQNQVRAAENVTKLTAEVASVAEETAASAEEVSAATEQQTASMQEVTNAAQELAKIAEKSQGLITKFKTDHADDEQQEKEEKKATASSVPAASAAEETAKSGGRKPLKLKAPFVVKKEGQKPMLGQIKVLHGRGGDKEEEEAVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUQ3</accession>
    <name>A0A075MUQ3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00964</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385086.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUQ3"/>
    <dbReference type="STRING" id="1459636.NTE_00964"/>
    <dbReference type="GeneID" id="43502583"/>
    <dbReference type="KEGG" id="nev:NTE_00964"/>
    <dbReference type="eggNOG" id="arCOG11928">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3038873_0_0_2"/>
    <dbReference type="OrthoDB" id="144at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="58" mass="6907" checksum="0583CCD347932D66" modified="2014-10-29" version="1">MQQRHMCKCAKVTFYEVEFKLSGMKVIPTHKNCGEGLNDDQFNSFEKELVKYWGFEQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUR3</accession>
    <name>A0A075MUR3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701819.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUR3"/>
    <dbReference type="STRING" id="1459636.NTE_03378"/>
    <dbReference type="GeneID" id="41599024"/>
    <dbReference type="KEGG" id="nev:NTE_03378"/>
    <dbReference type="HOGENOM" id="CLU_2353092_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="96" mass="9754" checksum="5057AD79BE37B4C1" modified="2014-10-29" version="1">MLSQLEGNEKEKVTRIMVASIVTGIAVAIAPSLIVWLSGVDINNIQTTSNTIAGSSGGLPPALANVLRNGFTVITVLGAVIAAGGLILGAIKMQLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUS5</accession>
    <name>A0A075MUS5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03388</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUS5"/>
    <dbReference type="STRING" id="1459636.NTE_03388"/>
    <dbReference type="KEGG" id="nev:NTE_03388"/>
    <dbReference type="HOGENOM" id="CLU_3362471_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="35" mass="4078" checksum="738BD9A8E720C7CF" modified="2014-10-29" version="1">MLQSFYTEFAAKLASDMHNVTHGHNSYVRADYEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUV6</accession>
    <name>A0A075MUV6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Putative nickel-responsive regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NTE_02910</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Transcriptional regulator.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
        <text evidence="6">Binds 1 nickel ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the transcriptional regulatory CopG/NikR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701434.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUV6"/>
    <dbReference type="STRING" id="1459636.NTE_02910"/>
    <dbReference type="GeneID" id="41598588"/>
    <dbReference type="KEGG" id="nev:NTE_02910"/>
    <dbReference type="eggNOG" id="arCOG01008">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113319_1_2_2"/>
    <dbReference type="OrthoDB" id="25654at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010045">
        <property type="term" value="P:response to nickel cation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22231">
        <property type="entry name" value="RHH_NikR_HicB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1150">
        <property type="entry name" value="ACT-like. Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="entry name" value="Met repressor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00476">
        <property type="entry name" value="NikR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027271">
        <property type="entry name" value="Acetolactate_synth/TF_NikR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050192">
        <property type="entry name" value="CopG/NikR_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022988">
        <property type="entry name" value="Ni_resp_reg_NikR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014864">
        <property type="entry name" value="TF_NikR_Ni-bd_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002169">
        <property type="entry name" value="PRK01002.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002815">
        <property type="entry name" value="PRK02967.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34719">
        <property type="entry name" value="NICKEL-RESPONSIVE REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34719:SF2">
        <property type="entry name" value="NICKEL-RESPONSIVE REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08753">
        <property type="entry name" value="NikR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="Ribbon-helix-helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 6" id="KW-0533">Nickel</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor NikR nickel binding C-terminal" evidence="7">
        <location>
            <begin position="69"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF84948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="148" mass="16919" checksum="C0906F619066006E" modified="2014-10-29" version="1">MPKRHSHSHRKKEPVDRISMSLSPDLLSEFDRSMKKAGFSDRSKAIQAALHSFIAQYDWDKGEDSRNGAGAIMMLYDNHAYNHDSESTHVQHHYSDIISASTHLHLDHDNCLETVMVRGEIRRIKELAKKLSESRGIKSLKVHFVSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUX0</accession>
    <name>A0A075MUX0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_02975</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701483.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUX0"/>
    <dbReference type="STRING" id="1459636.NTE_02975"/>
    <dbReference type="GeneID" id="41598646"/>
    <dbReference type="KEGG" id="nev:NTE_02975"/>
    <dbReference type="eggNOG" id="arCOG02643">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093735_0_0_2"/>
    <dbReference type="OrthoDB" id="135877at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.10">
        <property type="entry name" value="Tetracycline Repressor, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050624">
        <property type="entry name" value="HTH-type_Tx_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43479">
        <property type="entry name" value="ACREF/ENVCD OPERON REPRESSOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43479:SF11">
        <property type="entry name" value="ACREF_ENVCD OPERON REPRESSOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="Tetracyclin repressor-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="3">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="2">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF85010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="197" mass="21973" checksum="4398802C336B4E3A" modified="2014-10-29" version="1">MPKGKEEKAERIMEAALAVLSKNGYENTTINEVADAAKVSRGLLHYYFKDKEDMVSKSLAFGFGPMWDSSVGSLSGAKSPEELVDGMIEILKRNVQENSDFTALLFEMWVSSRRSAKIDKVFKDGLDEAINRLKALLEFASSVGVIKVDASEAEGIVRMLFAIYQGMAMQLILNPEKVKDKRMWTPIRRVLLAAFKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MV19</accession>
    <name>A0A075MV19_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01061</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699957.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MV19"/>
    <dbReference type="STRING" id="1459636.NTE_01061"/>
    <dbReference type="GeneID" id="41596881"/>
    <dbReference type="KEGG" id="nev:NTE_01061"/>
    <dbReference type="eggNOG" id="arCOG10358">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023082_0_0_2"/>
    <dbReference type="OrthoDB" id="12289at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="566" mass="60596" checksum="588F95014A01BA08" modified="2014-10-29" version="1">MAYAKVGKVVPLALLAMLAGSIATIAGPAIMTTKAFAHTDKPVDFVTNIEYIRGHLEKAIENKKAGNNTLAIAHAGHPVAEVYTLIKADIQGDDAALDTKLEGDLNTLFEQIGKNMTAADVEAKVADINASLDSAVTKVVGNDSNSTTLWAQVAMGLLSTSVEEYNEGVANGTIMQMVEYQDANAFIHRAEVIFGKIKPSMPEHEAEEATELFAELHSLSSANADSEKIETVIGGINNEITEGFKLGGAAVDSEKAGFAANVEMIKGHMSQAVKNVLNNNYELAAAHAGHPIAEHYALLKTELGEHNKALDGDLETALKGFAANIKNMSAVDTKAQVVKITRMLNTATADVVTGDTWADFKFRAAVTNTLLSTVQEEYAEAIQGGKIAQMVEYQDAEAFAARANVLFRTIQAQLPAHEAEEAKEILANLKTSMKNAQEPAAINTLVQGAIHEIQEGAGIQAVTAHETTPAEFIAKIRTLLGELKEEYAAGNYTKADSLAVEAYLDNFEHVEGPLVDAGQKGLMEEIEQLMRVQLREKISDKVPADQINAHIATILDKLAQAEKALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MV34</accession>
    <name>A0A075MV34_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Integral membrane protein, TerC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NTE_03071</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MV34"/>
    <dbReference type="KEGG" id="nev:NTE_03071"/>
    <dbReference type="eggNOG" id="arCOG09430">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045644_1_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005496">
        <property type="entry name" value="Integral_membrane_TerC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022369">
        <property type="entry name" value="Integral_membrane_TerC_rswitch"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03718">
        <property type="entry name" value="R_switched_Alx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30238">
        <property type="entry name" value="MEMBRANE BOUND PREDICTED REDOX MODULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30238:SF0">
        <property type="entry name" value="THYLAKOID MEMBRANE PROTEIN TERC, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03741">
        <property type="entry name" value="TerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF85105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="260" mass="28619" checksum="57271A16FA13019D" modified="2014-10-29" version="1">MGYDKMLEFVTGYAVEKSLSVDNMFVFLLIFSSLGIPHAFQHRVLSAGILSAIAMRIPLIVVGASLLETFHWMVYLFGGMLVLTAARMMLQKKEKKIEVEKNIAVRMLRRILPVSTELHGGKFLARINGTLYATALLVALVIIEVTDLVFAIDSIPAVLAITTDQFLVITSNIFAILGLRSLYFLLAGMMEKFRYLKPALVALLLFIGVKMVLSEVFHIPVVASLAVIAAILGGALVLSVIRAKKEQSSQQLAKSHDLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MV52</accession>
    <name>A0A075MV52_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MEDS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MV52"/>
    <dbReference type="STRING" id="1459636.NTE_03003"/>
    <dbReference type="KEGG" id="nev:NTE_03003"/>
    <dbReference type="HOGENOM" id="CLU_1418635_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025847">
        <property type="entry name" value="MEDS_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14417">
        <property type="entry name" value="MEDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MEDS" evidence="1">
        <location>
            <begin position="16"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="191" mass="21604" checksum="43754CCD2947FD3F" modified="2014-10-29" version="1">MYARMLRPIDLETSEHVMLLYDSDQVRDEVAAHYINEGIDEGQLVIYASVDAEDLAHLARLASRITEYQENISQGNLLIVSLKQCYQNALAGDLSPFGDIKKLVERASKERLDAGKGDGRAIIVADCADTLSKNEKFEECGIVENWWRNTCREWLKNNLQVTVICPHLHPMLDDSERELIGGYHSMTVKVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MV67</accession>
    <name>A0A075MV67_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Probable cobalamin biosynthesis protein CobD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">cobD</name>
        <name evidence="12" type="ORF">NTE_03116</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Cell membrane</location>
            <topology evidence="2 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the CobD/CbiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385609.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MV67"/>
    <dbReference type="STRING" id="1459636.NTE_03116"/>
    <dbReference type="GeneID" id="41598776"/>
    <dbReference type="KEGG" id="nev:NTE_03116"/>
    <dbReference type="eggNOG" id="arCOG04274">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054212_0_0_2"/>
    <dbReference type="OrthoDB" id="46105at2157"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015420">
        <property type="term" value="F:ABC-type vitamin B12 transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048472">
        <property type="term" value="F:threonine-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00024">
        <property type="entry name" value="CobD_CbiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004485">
        <property type="entry name" value="Cobalamin_biosynth_CobD/CbiB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00380">
        <property type="entry name" value="cobal_cbiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002281">
        <property type="entry name" value="PRK01209.2-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34308">
        <property type="entry name" value="COBALAMIN BIOSYNTHESIS PROTEIN CBIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34308:SF1">
        <property type="entry name" value="COBALAMIN BIOSYNTHESIS PROTEIN CBIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03186">
        <property type="entry name" value="CobD_Cbib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 11" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="12" id="KW-0436">Ligase</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="293"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIF85150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="323" mass="34977" checksum="24DC2AE51BFFDC27" modified="2014-10-29" version="1">MLLALIASLAGGIGLDVVAGDPPNRYHPVAWLGRLIGYFVPRLKAGSRAKERAKGAAFAILFVALVGAGVHLAAMVSLYLAGAVALAIFSAIILKVTVAVRGMDRHARAIMACLENGDLPGARQNLSRIVRRPTENLDEQHVLSATIECVSESTVDGITGPVFYYSLLGPAGAFAYRTINTLDSMVAYRDDYYRDIGWMSARLDTLANYVPARITAFLMVISARMLGADWKNSLGILQRDHNKTFSPNAGYPMATMAGALRIRLEKIGHYALGDSQEQASLEKCRTAIAMMKLTTLLFSLAFSVPAMSVLYLAGWWRLLLGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MV70</accession>
    <name>A0A075MV70_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03518</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MV70"/>
    <dbReference type="STRING" id="1459636.NTE_03518"/>
    <dbReference type="KEGG" id="nev:NTE_03518"/>
    <dbReference type="HOGENOM" id="CLU_3379842_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="33" mass="3888" checksum="6944490E9E7AB323" modified="2014-10-29" version="1">MTHRYTVYVGYPAFTLKGGGYYFRIIIDVLDTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVB1</accession>
    <name>A0A075MVB1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NADH dehydrogenase subunit L</fullName>
            <ecNumber evidence="8">1.6.5.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NTE_02550</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVB1"/>
    <dbReference type="STRING" id="1459636.NTE_02550"/>
    <dbReference type="GeneID" id="41598245"/>
    <dbReference type="KEGG" id="nev:NTE_02550"/>
    <dbReference type="eggNOG" id="arCOG01539">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007100_6_2_2"/>
    <dbReference type="OrthoDB" id="371891at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="entry name" value="ND/Mrp_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003945">
        <property type="entry name" value="NU5C-like"/>
    </dbReference>
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        <property type="entry name" value="Proton_antipo_N"/>
    </dbReference>
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        <property type="entry name" value="NDH_I_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42829">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42829:SF2">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00662">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01434">
        <property type="entry name" value="NADHDHGNASE5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="308"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="366"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="408"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="450"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <end position="519"/>
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    </feature>
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        <location>
            <begin position="554"/>
            <end position="576"/>
        </location>
    </feature>
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            <end position="622"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="655"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="domain" description="NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal" evidence="7">
        <location>
            <begin position="71"/>
            <end position="117"/>
        </location>
    </feature>
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        <location>
            <begin position="183"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00662"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AIF84597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="677" mass="73569" checksum="29AD17981C450E1E" modified="2014-10-29" version="1">MVETFANSINVWLIWILPFAGAAIIPAIAKGSKKARDYIAVGFALASAISAATLIPIGLAGHEVHSQVTWISALGLKAGVLADPLAIVMTNVVAWIAFLIFVYSLGYMHGDRDLTRYWFFMLFFIGSMQLIVISDNLLMVFFGWEGVGLASYALIGFWYHDRKKDYVGKEGHMAGGIPMWTAPTHAGMKAFLMTKAGDVMMLAGMFLIFAYAGTFGFKELVADQSWAAAMSQQNLLVPAAVLLFGGAVGKSAQFPLNEWLLEAMTGPTSVSALIHAATMVKAGVFLVARLGPLFFALSALNTSQFFEVVAWTGAITAFLLATQALVSPEIKKVLAYSTGSQIGYMMMALGIAGISLNFTDGYTAGFFHLMSHAMFKASLFMGAGALLHSVGSRFMTDMGGLRKDMRKTYIFMMLAALSLAGAPLFTSGFWSKDAIFAAILESGYTYSWPLFAMAVIVAVMTAFYTMRMIGMSFFGNKSKHLEEMEHKGHHVHEVGPVMWVPFAILAVATIAVGVVGFVFEEQLHELFSEYLGESFGIAPAHEATGRTFLNLNPIAAIASVGAFAVGAGLGFVFYIARKADPEAIGRNIITRGIWKFLYNRWYLNTALYWGGVIGPLAIYRFIWRYFESTVIDGINPAFQGAMAGMSKVVKSGQTGITQTYLFVFAVGIMIVVMLLLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVP5</accession>
    <name>A0A075MVP5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVP5"/>
    <dbReference type="GeneID" id="41597107"/>
    <dbReference type="KEGG" id="nev:NTE_01305"/>
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        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_923222_0_0_2"/>
    <dbReference type="OrthoDB" id="12212at2157"/>
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    </dbReference>
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        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="322" mass="36205" checksum="5C92D8AC3E28C5CC" modified="2014-10-29" version="1">MATDTPLGPESVKSAANLFAVLSRRDTLALFLLVKDGLRSELRTASSIGLSKKQYYTRLNQLKDAGLVEKHGDTYVYTTLGNVIHQRHISGLVENIRLTKQFRMIDTLKRAGEFSEEDISEFAKNIGGLDVQESLSSSSKIDLVWTYEEAASKLAETIEFAKQEIVFATRFLNEVLINSILNKTKAGVNVRILADAKMVNSFVEMEKKYLNLTDEHSLERLNMVRNPWYPRNVKRRIAHVPFSMAIIDGKHAGFELIGRSNSDKFTGAIFIKDKKACTGLMEFYQKIWDAASEDYYSSTTTMHDDGGCRAVASSRSSNLLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVS5</accession>
    <name>A0A075MVS5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01341</name>
    </gene>
    <organism evidence="1 2">
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        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
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            <taxon>Nitrososphaerales</taxon>
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            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVS5"/>
    <dbReference type="KEGG" id="nev:NTE_01341"/>
    <dbReference type="HOGENOM" id="CLU_3394433_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="31" mass="3222" checksum="FCCBA8275A7EC10F" modified="2014-10-29" version="1">MNVIGAKEISGIGTHGFESKKPSIVLNSFCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MW03</accession>
    <name>A0A075MW03_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF985 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02761</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MW03"/>
    <dbReference type="STRING" id="1459636.NTE_02761"/>
    <dbReference type="KEGG" id="nev:NTE_02761"/>
    <dbReference type="eggNOG" id="arCOG08247">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088365_0_3_2"/>
    <dbReference type="OrthoDB" id="10744at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06121">
        <property type="entry name" value="cupin_YML079wp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009327">
        <property type="entry name" value="Cupin_DUF985"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039935">
        <property type="entry name" value="YML079W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33387:SF3">
        <property type="entry name" value="DUF985 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33387">
        <property type="entry name" value="RMLC-LIKE JELLY ROLL FOLD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06172">
        <property type="entry name" value="Cupin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF985" evidence="1">
        <location>
            <begin position="5"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="161" mass="18189" checksum="2952E6473680F678" modified="2014-10-29" version="1">MDARAWVKALGLKEHPEGGYFKETYRAGMEIDLPGFDGRRSAGTAIYYLLKSGQFSAFHRIKSDEVWHFYAGSPLAVHVIDREDGKYQKMTIGKGKRPALQAVVKAGCWFAASVDKPHSYSLVGCTVAPGFDFRDWEAGWRDELLASYPEHKQIIVKFTRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MW52</accession>
    <name>A0A075MW52_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B</fullName>
            <shortName evidence="11">Asp/Glu-ADT subunit B</shortName>
            <ecNumber evidence="11">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">gatB</name>
        <name evidence="13" type="ORF">NTE_02817</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 11">Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>L-aspartyl-tRNA(Asn) + L-glutamine + ATP + H2O = L-asparaginyl-tRNA(Asn) + L-glutamate + ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14513"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="Rhea" id="RHEA-COMP:9677"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-glutamyl-tRNA(Gln) + L-glutamine + ATP + H2O = L-glutaminyl-tRNA(Gln) + L-glutamate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2 11">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the GatB/GatE family. GatB subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="11"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701360.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MW52"/>
    <dbReference type="STRING" id="1459636.NTE_02817"/>
    <dbReference type="GeneID" id="41598502"/>
    <dbReference type="KEGG" id="nev:NTE_02817"/>
    <dbReference type="eggNOG" id="arCOG01718">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019240_0_1_2"/>
    <dbReference type="OrthoDB" id="52755at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050566">
        <property type="term" value="F:asparaginyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070681">
        <property type="term" value="P:glutaminyl-tRNAGln biosynthesis via transamidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.380:FF:000001">
        <property type="entry name" value="Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.380">
        <property type="entry name" value="GatB domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00121">
        <property type="entry name" value="GatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017959">
        <property type="entry name" value="Asn/Gln-tRNA_amidoTrfase_suB/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006075">
        <property type="entry name" value="Asn/Gln-tRNA_Trfase_suB/E_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018027">
        <property type="entry name" value="Asn/Gln_amidotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004413">
        <property type="entry name" value="GatB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042114">
        <property type="entry name" value="GatB_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023168">
        <property type="entry name" value="GatB_Yqey_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017958">
        <property type="entry name" value="Gln-tRNA_amidoTrfase_suB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00133">
        <property type="entry name" value="gatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004012">
        <property type="entry name" value="PRK05477.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004014">
        <property type="entry name" value="PRK05477.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659">
        <property type="entry name" value="GLUTAMYL-TRNA GLN AMIDOTRANSFERASE SUBUNIT B MITOCHONDRIAL AND PROKARYOTIC PET112-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659:SF0">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02934">
        <property type="entry name" value="GatB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02637">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00845">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="GatB/YqeY motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01234">
        <property type="entry name" value="GATB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Asn/Gln amidotransferase" evidence="12">
        <location>
            <begin position="325"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIF84857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="479" mass="53103" checksum="44012B9489460ECB" modified="2014-10-29" version="1">MEYKIGLEIHCQLTGARSKLFCPCSCDYRGKEPNANICPTCTGLPGTLPLLNKKAVEFAGMISLALGCKVPEEIMFYRKNYFYPDLPKNFQLTQYNAYGITSIGVDGKLEYGNGKSVRMRRVQLEEDPGRLVYEGGSMEKSTYTLVDYNRAGVPLVEIVTEPDFVDPKDVREFLNKVTSIVEHLGVCDTRLEGSVRCDTNVSVAGGHRVEIKNVGSFSEVEKALRYEMARQKTMVSRDIEVKAETRHWDDARKVTKESRSKEEEQDYRYFPEPDIPSIELGAGFISSLEQSMPELPDARKARFVSSLGLTPHVAQVLIDNKELADFFESAIKIYNSPKEVANWIVTDLMGFVDEKAKEEQHAMLAGLKVGPEHIADLAKLVEQNTINRATAKQILGQVVKTGEMPSQVAKKTQASKIDDAGALAQAIDAVFAAETAAVADAKKNPAAANFLLGKVMQHTRGRADPKTALELINKKLRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWE2</accession>
    <name>A0A075MWE2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator with CheY-like receiver, AAA-type ATPase, and DNA-binding domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_02941</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701458.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWE2"/>
    <dbReference type="STRING" id="1459636.NTE_02941"/>
    <dbReference type="GeneID" id="41598619"/>
    <dbReference type="KEGG" id="nev:NTE_02941"/>
    <dbReference type="eggNOG" id="arCOG02391">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_15_2"/>
    <dbReference type="OrthoDB" id="2830at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050595">
        <property type="entry name" value="Bact_response_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44591:SF3">
        <property type="entry name" value="RESPONSE REGULATORY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44591">
        <property type="entry name" value="STRESS RESPONSE REGULATOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="2"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF84977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="170" mass="19248" checksum="63DD46A1283E5FF7" modified="2014-10-29" version="1">MKILVAEDEPNIAKVYKISFEERGHEVIVTHNGVECLEEYSRHLEQTSGHNAAPFDVVLLDYRMPKKDGMEVAREILALVPKQRIIFVSAYVLETLQDSVKTLSRVVEMMQKPFEIDDLVSLVEDTSIWKGLEQLNVNVGELRKMNATHDQLLGLYEGLRAIQKGRGIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWE7</accession>
    <name>A0A075MWE7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03542</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWE7"/>
    <dbReference type="KEGG" id="nev:NTE_03542"/>
    <dbReference type="eggNOG" id="arCOG01063">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_160435_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038723">
        <property type="entry name" value="ArnR1-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14947">
        <property type="entry name" value="HTH_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ArnR1-like winged helix-turn-helix" evidence="1">
        <location>
            <begin position="18"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="128" mass="14431" checksum="69630252E04D2DF4" modified="2014-10-29" version="1">MQPYLIALAMSGSPSSYRDRIYIVKDIILKLIEYGELNQTALVSFCGLNLKKHKPILEELESNGLIGRQESVAGKRTVTIYRPTQKGLQFCRDILEPYERMFPRRKDDKGSGGSSGLSTMMSTMLILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWI5</accession>
    <name>A0A075MWI5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02977</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701485.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWI5"/>
    <dbReference type="STRING" id="1459636.NTE_02977"/>
    <dbReference type="GeneID" id="41598648"/>
    <dbReference type="KEGG" id="nev:NTE_02977"/>
    <dbReference type="HOGENOM" id="CLU_1465153_0_0_2"/>
    <dbReference type="OrthoDB" id="9161at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="185" mass="19800" checksum="97B8BBE7299E6F65" modified="2014-10-29" version="1">MKAQPLERQHKALLIIASVIVKTFLMVLVATQVMCGSTDPRALFSCGTNAAYVGTSAAAVAIMGFVFGHYIVRLKSFNKIFANMMGADFIVTAMYFGVAFTAPNVVATKTMIWLFGTWILGMLLAPFNSEKTFLKKVAQYGGIVALGALFSLELIPGFAELGQSYTAGMMVSSILSVFGGGRQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWS2</accession>
    <name>A0A075MWS2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Inositol monophosphatase/fructose-1,6-bisphosphatase family protein</fullName>
            <ecNumber evidence="6">3.1.3.25</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NTE_03535</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="3.1.3.25" evidence="6"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701937.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWS2"/>
    <dbReference type="STRING" id="1459636.NTE_03535"/>
    <dbReference type="GeneID" id="41599153"/>
    <dbReference type="KEGG" id="nev:NTE_03535"/>
    <dbReference type="eggNOG" id="arCOG01349">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044118_5_0_2"/>
    <dbReference type="OrthoDB" id="58111at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008934">
        <property type="term" value="F:inositol monophosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006020">
        <property type="term" value="P:inositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.80:FF:000020">
        <property type="entry name" value="Fructose-1,6-bisphosphatase/inositol-1-monophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20854">
        <property type="entry name" value="INOSITOL MONOPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20854:SF4">
        <property type="entry name" value="INOSITOL-1-MONOPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR600760-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF85563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="262" mass="28169" checksum="A9EF74D58C703F22" modified="2014-10-29" version="1">MTIIGALKDACREVHARTRGVAGTARGNRQTGRRGAGGDISRQIDLLAEKTAINVLKKHGIDATIIGEECGRIEGKEGYVIMDAIDGTTNASRQLPFYCCSLAYADEFQLSAVKDAAIINLVNGDLYYASKNKGAFCNGKRIRVREAGDDVVIGMNVSGINDDVIKRLAPVMSKANHVRQLGSLAIELCYLAKGSLDASIDFRGKVRPVDIAAACLIVREAGGQVYSDKGVDLDCELGVETRVSFVATAHEKVFRDLSTDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MX17</accession>
    <name>A0A075MX17_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphate transport regulator related to PhoU</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_01763</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0111 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700526.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MX17"/>
    <dbReference type="STRING" id="1459636.NTE_01763"/>
    <dbReference type="GeneID" id="41597533"/>
    <dbReference type="KEGG" id="nev:NTE_01763"/>
    <dbReference type="eggNOG" id="arCOG02640">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1269985_0_0_2"/>
    <dbReference type="OrthoDB" id="9933at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="entry name" value="Phosphate transport system protein phou homolog 2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002727">
        <property type="entry name" value="DUF47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018445">
        <property type="entry name" value="Put_Phosphate_transp_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36536">
        <property type="entry name" value="UPF0111 PROTEIN HI_1603"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36536:SF3">
        <property type="entry name" value="UPF0111 PROTEIN HI_1603"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01865">
        <property type="entry name" value="PhoU_div"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="40"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF83824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="217" mass="24279" checksum="873D9F510D444A3B" modified="2014-10-29" version="1">MYSGELEVQAKRKALAILQDEISKILSSSRDLSTLTSSLIKDDNNDIQACLERLRNNEEEVENLRRKITREVSELGGLMANREDILRTAYLMDDVAGYINGIAFRLANMKGETLKKAQCDVDLQELVGMVVDASFKLNEMGRALSINPASMFEHAQEMQKLEHQVDAKYRAMIIKALGEITNNKDLLLFKDAVEGIEGMVDKCQEASDSFTILALGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MXM7</accession>
    <name>A0A075MXM7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative signal-transduction protein containing cAMP-binding and CBS domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_01996</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MXM7"/>
    <dbReference type="STRING" id="1459636.NTE_01996"/>
    <dbReference type="KEGG" id="nev:NTE_01996"/>
    <dbReference type="eggNOG" id="arCOG00606">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040681_12_2_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051257">
        <property type="entry name" value="Diverse_CBS-Domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43080:SF2">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43080">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN CBSX3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="26"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="92"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF84054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="170" mass="18592" checksum="6DD99C4451B467BD" modified="2014-10-29" version="1">MPLRQGLNFQPSKVALVVAGVVRDIMTKEIVTIDADRSALEAAKLMTEKGISSVFIVNRDGNPIGIVSERDFIKKICAKELVISQVKVGDIMSKILTTAGPETAIEVAVQRMVNHKIRRLPIMEGNKVVGIITVTDLAKHLRTTLLLEGALRDTESIDDVIATMGHDEKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MXQ5</accession>
    <name>A0A075MXQ5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02022</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MXQ5"/>
    <dbReference type="STRING" id="1459636.NTE_02022"/>
    <dbReference type="KEGG" id="nev:NTE_02022"/>
    <dbReference type="HOGENOM" id="CLU_3178707_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="46" mass="5574" checksum="89292C34EF9C33E9" modified="2014-10-29" version="1">MNRTAHEVIEEPDAIYTYKRRRLYRCRECGHKSFKRGLRPSAESVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MXX0</accession>
    <name>A0A075MXX0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02078</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MXX0"/>
    <dbReference type="STRING" id="1459636.NTE_02078"/>
    <dbReference type="KEGG" id="nev:NTE_02078"/>
    <dbReference type="HOGENOM" id="CLU_084395_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="259" mass="28466" checksum="297BF8BC0E09A353" modified="2014-10-29" version="1">MLANNMPSSSSSEASANISSMLMNKGNRLNMIGDPANKLEASSSSISRQEIVVELERRGINASLFGELSIDQLGDMLRAITRIIIANGPGKKRQISSHSGGRKNLALSSLDKKILRGLLSSKGKVSSITLSKETGAPLSTVQRRRKRLEANFLETSYLPRVKSLGWRVAMVFVSTQGGTAIEVGKELLSWKKAVIRVSRATGLETTDIAAEVIFYENEDLLNIIERVRAITGVRNLFWVEVIDTLGKNNQCFEFILDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MY48</accession>
    <name>A0A075MY48_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03554</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_193354080.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MY48"/>
    <dbReference type="GeneID" id="59387799"/>
    <dbReference type="KEGG" id="nev:NTE_03554"/>
    <dbReference type="HOGENOM" id="CLU_3002964_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058463">
        <property type="entry name" value="DUF8150"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26477">
        <property type="entry name" value="DUF8150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="56" mass="6812" checksum="D35CDB24110140D4" modified="2014-10-29" version="1">MKKKLPEINLKELEKLKEENFRERLEFLDKYADWVKKTDNSKWSSAQKAIINRKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MZY3</accession>
    <name>A0A075MZY3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">7-carboxy-7-deazaguanine synthase</fullName>
            <shortName evidence="8">CDG synthase</shortName>
            <ecNumber evidence="8">4.3.99.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Archaeosine biosynthesis protein QueE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">queE</name>
        <name evidence="10" type="ORF">NTE_02763</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>6-carboxy-5,6,7,8-tetrahydropterin + H(+) = 7-carboxy-7-carbaguanine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:27974"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:61032"/>
            <dbReference type="ChEBI" id="CHEBI:61036"/>
            <dbReference type="EC" id="4.3.99.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </cofactor>
        <text evidence="8">Binds 1 S-adenosyl-L-methionine per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="8">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">Purine metabolism; 7-cyano-7-deazaguanine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.3.99.3" evidence="8"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MZY3"/>
    <dbReference type="STRING" id="1459636.NTE_02763"/>
    <dbReference type="KEGG" id="nev:NTE_02763"/>
    <dbReference type="eggNOG" id="arCOG02173">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066739_1_0_2"/>
    <dbReference type="OrthoDB" id="7980at2157"/>
    <dbReference type="UniPathway" id="UPA00391"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016840">
        <property type="term" value="F:carbon-nitrogen lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00917">
        <property type="entry name" value="QueE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024924">
        <property type="entry name" value="7-CO-7-deazaguanine_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42836">
        <property type="entry name" value="7-CARBOXY-7-DEAZAGUANINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42836:SF1">
        <property type="entry name" value="7-CARBOXY-7-DEAZAGUANINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13353">
        <property type="entry name" value="Fer4_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000370">
        <property type="entry name" value="QueE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 8" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5 8" id="KW-0408">Iron</keyword>
    <keyword evidence="6 8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="9">
        <location>
            <begin position="29"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="23"/>
            <end position="25"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="48"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIF84804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="250" mass="28430" checksum="803A70A0855F4B8D" modified="2014-10-29" version="1">MQREQQGRRTAGTVRLSEIFTSIEGEGVFFGTKTMFVRLAGCPLKCHWCDTPYAIPMDSGESHTVEEVKEMISNDLQENTYKVNFTGGEPLAQHEAVMELAKFVREKKGVKTYLESACYDSARFAKVLPYIDICKIEFKMKDARAVVDDKHYNNLLKNELECLRIAVDAGKMPYVKVVVTNSTDVDEFASLVRQVFRVASPKNIAGFIIQPSHKTDEPVLERLFAFYDAVYPFYDQVRVVPQLHKIIGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N062</accession>
    <name>A0A075N062_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02851</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701387.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N062"/>
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    <dbReference type="eggNOG" id="arCOG10597">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1514545_0_0_2"/>
    <dbReference type="OrthoDB" id="12184at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="177" mass="18547" checksum="9BE6C6A8021078BB" modified="2014-10-29" version="1">MVSTTLYLSVALAAILAAGFAVIPAAHAQTGAPAAGGKKSLDIAIQPEWSDGANAKLNVSFYNPGTTTLHQHQDYDVVVLQNGNEIFRASKQVNQPVLHNVEGKLSVPYKFPSNGQYTVRVELLGLGLPPVPITPEHTDLSINVVPEFPAGALAAVAAVTMGGAVVVARIKKMKKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N0Z5</accession>
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        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL42</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl44e</name>
        <name evidence="7" type="ORF">NTE_03120</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the eukaryotic ribosomal protein eL42 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N0Z5"/>
    <dbReference type="STRING" id="1459636.NTE_03120"/>
    <dbReference type="GeneID" id="41598780"/>
    <dbReference type="KEGG" id="nev:NTE_03120"/>
    <dbReference type="eggNOG" id="arCOG04109">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114645_3_0_2"/>
    <dbReference type="OrthoDB" id="52456at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.80:FF:000001">
        <property type="entry name" value="60S ribosomal protein L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01476">
        <property type="entry name" value="Ribosomal_L44e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000552">
        <property type="entry name" value="Ribosomal_eL44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053708">
        <property type="entry name" value="Ribosomal_LSU_eL42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004425">
        <property type="entry name" value="PRK05767.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10369">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L36A/L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00935">
        <property type="entry name" value="Ribosomal_L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01172">
        <property type="entry name" value="RIBOSOMAL_L44E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="zinc finger region" description="C4-type" evidence="4">
        <location>
            <begin position="11"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF85154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="90" mass="10669" checksum="0CF08131A00359B1" modified="2014-10-29" version="1">MKMEKEMRKFCPRCKTHTMQSVAIYKKGKDRTVAEGARRHAEDKKGYGGQKFPELKRTAKTTKKITLRYTCKTCQRKTMKEGRRIRKLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N122</accession>
    <name>A0A075N122_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Chaperone protein DnaJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NTE_03147</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701622.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N122"/>
    <dbReference type="STRING" id="1459636.NTE_03147"/>
    <dbReference type="GeneID" id="41598806"/>
    <dbReference type="KEGG" id="nev:NTE_03147"/>
    <dbReference type="eggNOG" id="arCOG02846">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
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        <property type="entry name" value="PRK10767.1"/>
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    </dbReference>
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        <property type="entry name" value="CHAPERONE PROTEIN DNAJ A6, CHLOROPLASTIC"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="JDOMAIN"/>
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        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0346">Stress response</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="10">
        <location>
            <begin position="6"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="11">
        <location>
            <begin position="147"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="9">
        <location>
            <begin position="147"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIF85179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="374" mass="41835" checksum="0784F967120D7DC0" modified="2014-10-29" version="1">MSKKRDYYEVLGIQKTASKEDIKSAYRKLALQYHPDRNKDSGAEERFKEISEAYAVLSDDEKRKRYDTYGHVGAEEVFRGSEANFEEIFRDMGGFGGFRDIFEQFFGRGGGFGFGGGAADMFGFGGRRKGRDLVYDMELSLEDVLRGKKEEVEVPRLDRCSECGGSGAAPGTKARRCTVCDGRGQVQRVYGQNRFFTSVTVEPCRTCQGRGQIIERPCSVCKGSGKMQKMKKLKIEIPPGVEDGMAMQLRGEGEMSESGIPGDFVVHLHIKPHQQFERLEDGHLLYRLDVKYTDLALGTEMRVPTLDGTEKLKIPQGTQPEGLLRLKGKGLPRYGASGKGDMVIKLNVKVPTKLSDRQKSLLKELDRALDNDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N1C5</accession>
    <name>A0A075N1C5_9ARCH</name>
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        <submittedName>
            <fullName evidence="4">Ferritin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_03240</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:heme binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30295">
        <property type="entry name" value="BACTERIOFERRITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30295:SF1">
        <property type="entry name" value="DNA PROTECTION DURING STARVATION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0409">Iron storage</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin/DPS" evidence="3">
        <location>
            <begin position="23"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF85269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="169" mass="19260" checksum="DE5C29295EBA524B" modified="2014-10-29" version="1">MIKTSMGKKSLEIAGPGVDGTVAMLHKAYAFEMSTFHYFQYVANNIEGLGVLHEDFFDERAEEELGHAEEVNERLMELGTNPTDDPARWEQESGVGKLEPKRYLSLRSAIEKALEFERVAIGLYNDLANATKDKDHGTYQLALKLLHDELEDEQTMEDILARLEIQDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N1J0</accession>
    <name>A0A075N1J0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N1J0"/>
    <dbReference type="STRING" id="1459636.NTE_03305"/>
    <dbReference type="KEGG" id="nev:NTE_03305"/>
    <dbReference type="HOGENOM" id="CLU_2730556_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="71" mass="8227" checksum="1EEAA813384271F5" modified="2014-10-29" version="1">MQQHLLSNCYKEKQMRITWPDGTNVKANFYVKGDKKSRVAVQQNRLAKAADMARAKKRWHGALDRLEVLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N1R9</accession>
    <name>A0A075N1R9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03376</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701817.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N1R9"/>
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    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="91" mass="10864" checksum="AF279FE26B9E8A6D" modified="2014-10-29" version="1">MLLKTKYWRYFLRFCASTGFEISTLQEIISSLEQDRAKRVGDYSFLLVSKEKERFGTVYRIEVYHRNELVLKSPVLLRAPLKEYNRHSNVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N1S5</accession>
    <name>A0A075N1S5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">NTE_03381</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="KEGG" id="nev:NTE_03381"/>
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    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="entry name" value="TAT_signal"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="245" mass="26882" checksum="CC91FA7BFDE8BAB7" modified="2014-10-29" version="1">MSNNRRTFVLFSAFGAVALAIVLAFSSGVRTPMPTTNLDAASTIDSQILTSVVASEEDLPAIASSKDIPFRGPTSDNMKYFLIGYPLAIKMESANKVNIGDYPWLAGIVNSGETIVTPEQAAQFLSGFKDNNFFAIALLDGTTKYYNIDVYNIDLIPGKAYVKAYFMNDFEGKPSKQISEADVPFLKIAIENMDIWTPLDEPSDASALKTMLDDSKVKNFEVVKNDGKIELYNIRLIDSAQETVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N1V8</accession>
    <name>A0A075N1V8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NTE_03411</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N1V8"/>
    <dbReference type="STRING" id="1459636.NTE_03411"/>
    <dbReference type="KEGG" id="nev:NTE_03411"/>
    <dbReference type="eggNOG" id="arCOG04548">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050572">
        <property type="entry name" value="Fe-S_Ferredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43687">
        <property type="entry name" value="ADENYLYLSULFATE REDUCTASE, BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43687:SF6">
        <property type="entry name" value="L-ASPARTATE SEMIALDEHYDE SULFURTRANSFERASE IRON-SULFUR SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13187">
        <property type="entry name" value="Fer4_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="9">
        <location>
            <begin position="80"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="9">
        <location>
            <begin position="141"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="127"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIF85439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="197" mass="21599" checksum="00D161A5103BCB09" modified="2014-10-29" version="1">MQLSANASLISDFKLITSMPIDADFPKNHQVIGKHQHADGAHFHFVWGPGREAEAAENEEVRKAYEARGEQLVPLGVHGTMVALDWDSCIADGACIEACPVQVYQWYRSEQDVPGIEMQNATSAGSGEDHSRDGRKDYTDKSDPIREHDCIWCMACVSVCPTQAIKVDQSNLEFHEKAAGTFNEALAKGSAPPPHAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N1Y0</accession>
    <name>A0A075N1Y0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N1Y0"/>
    <dbReference type="STRING" id="1459636.NTE_03431"/>
    <dbReference type="KEGG" id="nev:NTE_03431"/>
    <dbReference type="HOGENOM" id="CLU_1718129_0_0_2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="152" mass="16977" checksum="89880A09F43F4E7E" modified="2014-10-29" version="1">MIVIEKDLMSYFIIKRRLTDVLVQWAAYGSAFSIMSFFSSILVHKDGASDRYIFRGDHHYTSNFKAAIAILITVVVGIAVEEFVLQPYLISVYEVNLGKIVQLLVASGLALFLTIWWHAGLMDKAENILGFIGGCVLAATLFADGFRVIPLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ML93</accession>
    <name>A0A075ML93_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oxygen-sensitive ribonucleoside-triphosphate reductase</fullName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NTE_00109</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.17.4.2" evidence="6"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699236.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ML93"/>
    <dbReference type="STRING" id="1459636.NTE_00109"/>
    <dbReference type="GeneID" id="41596051"/>
    <dbReference type="KEGG" id="nev:NTE_00109"/>
    <dbReference type="eggNOG" id="arCOG00734">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG04889">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023341_0_0_2"/>
    <dbReference type="OrthoDB" id="139164at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031250">
        <property type="term" value="C:anaerobic ribonucleoside-triphosphate reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008998">
        <property type="term" value="F:ribonucleoside-triphosphate reductase (thioredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009265">
        <property type="term" value="P:2'-deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055771">
        <property type="entry name" value="DUF7347"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012833">
        <property type="entry name" value="NrdD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21075">
        <property type="entry name" value="ANAEROBIC RIBONUCLEOSIDE-TRIPHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21075:SF0">
        <property type="entry name" value="ANAEROBIC RIBONUCLEOSIDE-TRIPHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03477">
        <property type="entry name" value="ATP-cone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24038">
        <property type="entry name" value="DUF7347"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13597">
        <property type="entry name" value="NRDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51998">
        <property type="entry name" value="PFL-like glycyl radical enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-cone" evidence="5">
        <location>
            <begin position="122"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF82191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="720" mass="77291" checksum="D7C2BDDAFC5BF530" modified="2014-10-29" version="1">METEPSFDYSQLQQRESRKGGVLESASKRVRMIFSVMASPNRIDILRILNTKGPLTYSELKALAGFKSKKESGKFAYHLRKLLRQLLVALNKAERRYTITNLGKLVLSLARQIEERSIIESGKMYVRTGRQTIEEFNSHKIIQSLVREANLPLEQAHKITEEVENKIYKFQTAYLTSSLIRETVNSVLIEHGHEEYRNKLARIGLPPSDISEMLSSEDATRSGAAGVMAKTAGSVFSEYLIFNTLPKDIADMHLAGEIHIAQPGAWGLLPDTLFVDLSDMEDGSLDLACRHPAVARFASIKTADDMLAALPVLIALLLREASAEVVLEGIAPPLAKAKDTDDLAAKFARALVSSSAAAAGAGQQQQQPLATLVVPAGDTAADAKQLNALLDGYRRYVDATPVPRVGLAITHGGKLKDSIDHITAAVRSGGIITIGSNDNNNNTARSSSGIRKTMAATNGKGSSSSAAMSLQALSINLPRLAYESNKDETYFRAKLALAIKPSLAAMAMRKKAVMDNARRGLLPAFSAATHSMQHATSSIVINLTGAHESVFSILGHDEANSGVEVMQKVLKTAVDVAAAQGKQLGEDSCGVAMIADDSGTRFAALDSEKYGKVSLLQSQNTTSYSQGMTLNGKELDKKQQLAAECSAIDKILNGGLAATVDVTDLGAGEAKSAIEAAAAELAFFRPRAWLAVCATCGKKYKMSADRCESCKSPHRLLTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLG2</accession>
    <name>A0A075MLG2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987096.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLG2"/>
    <dbReference type="STRING" id="1459636.NTE_00199"/>
    <dbReference type="GeneID" id="41596124"/>
    <dbReference type="KEGG" id="nev:NTE_00199"/>
    <dbReference type="eggNOG" id="arCOG11722">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1590792_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="167" mass="19165" checksum="F501543FE286AD70" modified="2014-10-29" version="1">MTTATTIPLRDRLVVLSCWLGIAITIRVILYNLHWLGSLGAIGITFLIITLFLKSNYGKKHDKRFKRVLRYWFSRKFQWASLGFLIFAVFMIISIDRGYARFGDNIEASIEPGLHIAGLDRFAFLAAYADHSSNGVFSWSSWIIVYEDAEYLIFLILVRKGLVFSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLT7</accession>
    <name>A0A075MLT7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00379</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLT7"/>
    <dbReference type="STRING" id="1459636.NTE_00379"/>
    <dbReference type="KEGG" id="nev:NTE_00379"/>
    <dbReference type="HOGENOM" id="CLU_2140089_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="112" mass="12980" checksum="71FB0D84CCECA358" modified="2014-10-29" version="1">MYTHIHRSIGELCYRLFLSRKCQYSIDVFKNMRLFGWKPKGKMYSLRCGQCGEGFLSSYHLEAPICGKCLQKAKSLNSTIEHEKQCQGCGSQGVIYGKQYCYSCYFGFQKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLX1</accession>
    <name>A0A075MLX1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF541 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00419</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLX1"/>
    <dbReference type="STRING" id="1459636.NTE_00419"/>
    <dbReference type="KEGG" id="nev:NTE_00419"/>
    <dbReference type="eggNOG" id="arCOG04715">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080344_4_2_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.170">
        <property type="entry name" value="Protein of unknown function (DUF541), domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2970">
        <property type="entry name" value="Protein of unknown function (DUF541), domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052022">
        <property type="entry name" value="26kDa_periplasmic_antigen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007497">
        <property type="entry name" value="SIMPL/DUF541"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34387">
        <property type="entry name" value="SLR1258 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34387:SF2">
        <property type="entry name" value="SLR1258 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04402">
        <property type="entry name" value="SIMPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="28194" checksum="A7AAF4B51D3C06DD" modified="2014-10-29" version="1">MLYMFAPLGKSSMLAIQLAAIAAAVLATSHLLYGSNAFAQIAPVPSPPPPPPPQPPQNFTTLEHTILVSGTASTKAIPDRAIVTFAVETRDATAAAALERNSDAMNKVLAALEEVGVQKNETSTAYFNIFPIYNYTQTGNVQSLQGYTVTNSLTVSSANTGNVSSWIDAAVQAGANRVDNVQFVFSNEQLAKIQSDLLENAIDNARAKADTIAAKLGVQITGVQSIVSIDSGYIPGPLYAAQARLGPSGTPIVVGAQEISASVSVIYIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MML3</accession>
    <name>A0A075MML3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00406</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699448.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MML3"/>
    <dbReference type="STRING" id="1459636.NTE_00406"/>
    <dbReference type="GeneID" id="41596286"/>
    <dbReference type="KEGG" id="nev:NTE_00406"/>
    <dbReference type="eggNOG" id="arCOG08730">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1745605_0_0_2"/>
    <dbReference type="OrthoDB" id="7069at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="156" mass="18026" checksum="3727DC65D60FFF29" modified="2014-10-29" version="1">MQEEEPRAPVVRFSEFLGMGYFGDERQDVVAPIFDSRHNAEKGWSRVMDMHGNSPAFHAVFVEHPAKYEFIAYPLAMNPAQINYVIYRSFSSLASLHKFKETHDGRTYIKFGWQDITKPQKFDVLAQYAFVDAVEFLAIQDVKGGTMVDRIRKNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMQ1</accession>
    <name>A0A075MMQ1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00348</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMQ1"/>
    <dbReference type="KEGG" id="nev:NTE_00348"/>
    <dbReference type="HOGENOM" id="CLU_3147796_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="48" mass="5294" checksum="2F823FFB979A2954" modified="2014-10-29" version="1">MTVNTFSILTIEHFDMSPAPLLALDIAAKNARKGAGTYQLLDLFRITN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMV0</accession>
    <name>A0A075MMV0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Arginase family hydrolase, arginase/agmainase/formiminoglutamate hydrolase</fullName>
            <ecNumber evidence="5">3.5.3.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_00681</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the arginase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.11" evidence="5"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699667.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMV0"/>
    <dbReference type="STRING" id="1459636.NTE_00681"/>
    <dbReference type="GeneID" id="41596538"/>
    <dbReference type="KEGG" id="nev:NTE_00681"/>
    <dbReference type="eggNOG" id="arCOG01700">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039478_0_2_2"/>
    <dbReference type="OrthoDB" id="7186at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008783">
        <property type="term" value="F:agmatinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033389">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via agmatine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="ARGINASE/AGMATINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358:SF26">
        <property type="entry name" value="GUANIDINO ACID HYDROLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036979">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR036979-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF82761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="311" mass="34977" checksum="C44D5E00C04D6BEE" modified="2014-10-29" version="1">MDKGFFDLFVVPEKTKAGYSFADTPVRISFQEAKVAVYGVPLDATTSFGRGTARGPEAIRLTSARQIETFVLDEKADVYELSSIFDLGDLKMPPKNKGAKTMFAYLDRTIPQVVSTLRENGKIPVMLGGEHTLSYYQLKVLAGEEPFVIHFDAHRDMKAEYEGMKMCHTTPFYHLLEYIPGKDLVQIGIRQTDREENDTAIKNGVTTFDAWQVHDDLDKVADFLAKKTAGRNIYISFDIDAYDLPYVPCTGTPEPYGLDPFQVLRLIKAVHPSARLIGMDMVEVGLKNDDYREGALATQTLLRILARKYAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MN09</accession>
    <name>A0A075MN09_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prefoldin alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00453</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MN09"/>
    <dbReference type="STRING" id="1459636.NTE_00453"/>
    <dbReference type="KEGG" id="nev:NTE_00453"/>
    <dbReference type="eggNOG" id="arCOG00991">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116577_2_0_2"/>
    <dbReference type="OrthoDB" id="7576at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21149">
        <property type="entry name" value="PUA_archaeosine_TGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.90">
        <property type="entry name" value="ArcTGT, C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029402">
        <property type="entry name" value="TGT_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038250">
        <property type="entry name" value="TGT_C2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14810">
        <property type="entry name" value="TGT_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88802">
        <property type="entry name" value="Pre-PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PUA" evidence="1">
        <location>
            <begin position="90"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="170" mass="18085" checksum="51D34810B8139588" modified="2014-10-29" version="1">MPKLNPLPLDARDKVCRHIDALFGAGVSETLPATDNDNSMKFEYSRKTGRIKNFSIDGALAATLRTDGGLALTVEGAQFFVNNSRAFLENCVVPAEEAVPFVSEGRSLFCRHVTWCGSNVKAGSDIAVLDKKENGSVIAVGIAILGAGLMNKFSKGVAVKVREGIKGRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MN15</accession>
    <name>A0A075MN15_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00808</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699765.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MN15"/>
    <dbReference type="GeneID" id="41596655"/>
    <dbReference type="KEGG" id="nev:NTE_00808"/>
    <dbReference type="HOGENOM" id="CLU_177467_0_0_2"/>
    <dbReference type="OrthoDB" id="6617at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="104" mass="11761" checksum="3FADD32DBC986496" modified="2014-10-29" version="1">MSNVDYNVESGKGYQEGASKFKPIKVEMRVSNVNKDQVSYWINEIANQYADLVVTNVSTGSDKISFDIGSPSMSDLTAEDIKFRIEEYLTMNVPPFELKELKVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MN69</accession>
    <name>A0A075MN69_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">NTE_00160</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699274.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MN69"/>
    <dbReference type="STRING" id="1459636.NTE_00160"/>
    <dbReference type="GeneID" id="41596096"/>
    <dbReference type="KEGG" id="nev:NTE_00160"/>
    <dbReference type="eggNOG" id="arCOG02358">
        <property type="taxonomic scope" value="Archaea"/>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
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        <property type="entry name" value="HisK_dim/P_dom"/>
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        <property type="entry name" value="Sensor_HK_Regulatory"/>
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        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
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        <property type="entry name" value="HISTIDINE KINASE 1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="TWO-COMPONENT HISTIDINE KINASE"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
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    </dbReference>
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        <property type="entry name" value="HIS_KIN"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="14">
        <location>
            <begin position="369"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="521"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AIF82242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="626" mass="68714" checksum="519FB3113348D0DB" modified="2014-10-29" version="1">MLQKKSLLLIVLIAAGATSLSIASYQYHDSTSNRITSLAKRDIHDNAIIEANAISRALSTKIADVAGNLRLLANAPSVQNGDVTGQQLFDSSQTITSDLTDGYYWIDRDGKIVTYSEINTGKFPDYRGDDLSFREYYKVPKQTLKPFISTVIDSRDGVLRLYLSHPIVDLKGNFSGVVVAAISTKNAGDFVQSQLLPQYRSTVGLMDRDGLILYSNNQTLIGIHYDDAMFQSVVPDPIKAQFNSFLERSKINTSEVEDISYGPNTVTIASKAVLINGEHSWTAYIVYPHVLTDETASLLNQQSTFNIVIIVAIGIAAILTAAMVLTWNKRLEMVVEKKTVELKHAADSLARVNEQLRERDKMQTEFINIAAHELRTPIQPVLGVIELLKQSAAGKAKTEITDRQLAIMDRNARRLQKLSSEILDATRIEAGTLRLDMEVMDINENIRNAIADTKSWIPDDQKKSLQIRFRPVAIDEFGYPIPLLVKADKLRIFQVISNLLRNAIKFSAEEGGSKGVIITVTTDKRDGDDGNNDDNNSDGGGNGGGGYAIVSVKDCGAGISAEVLPRLFTKFSTDRERGGTGLGLFIAKNIVEAHGGRIWAENNNSSEDGKRGATFSFMLPLAAAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MN97</accession>
    <name>A0A075MN97_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transcription factor S, archaeal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NTE_00945</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699873.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MN97"/>
    <dbReference type="STRING" id="1459636.NTE_00945"/>
    <dbReference type="GeneID" id="41596780"/>
    <dbReference type="KEGG" id="nev:NTE_00945"/>
    <dbReference type="eggNOG" id="arCOG00579">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093932_3_2_2"/>
    <dbReference type="OrthoDB" id="72957at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10511">
        <property type="entry name" value="Zn-ribbon_TFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006288">
        <property type="entry name" value="TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01384">
        <property type="entry name" value="TFS_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF12">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005586">
        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00466">
        <property type="entry name" value="ZF_TFIIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 6 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="8">
        <location>
            <begin position="65"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="6">
        <location>
            <begin position="4"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="4"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF83021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="108" mass="12274" checksum="792752BEAB801B41" modified="2014-10-29" version="1">MRFCPECQTRLRPSGDDVVCQKCGFKAKKGASDGKSVTEVKQVTGRDASLKVMDDDNKQQDLPTITIQCPTCDNNTAVWWMLQTRSADEATTQFFRCTKCNHTWRNYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNC6</accession>
    <name>A0A075MNC6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Isoleucine patch superfamily enzyme, carbonic anhydrase/acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00579</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699586.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNC6"/>
    <dbReference type="STRING" id="1459636.NTE_00579"/>
    <dbReference type="GeneID" id="41596444"/>
    <dbReference type="KEGG" id="nev:NTE_00579"/>
    <dbReference type="eggNOG" id="arCOG01849">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064827_3_0_2"/>
    <dbReference type="OrthoDB" id="10940at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052265">
        <property type="entry name" value="Gamma-CA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43360">
        <property type="entry name" value="CARBON DIOXIDE CONCENTRATING MECHANISM PROTEIN CCMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43360:SF1">
        <property type="entry name" value="CARBOXYSOME ASSEMBLY PROTEIN CCMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="291" mass="31093" checksum="B2FFAB3269E328DF" modified="2014-10-29" version="1">MKYANIASTIAAIGAILALALVLVQPSQQQQQQQTAATGLLRTRPWPPNVHTNVRTDFNPQASTPQISDSAFIHPYAIVIGDCHIGKMVMVAPTAVCRGDEGTPIHVGDYSNMQDGVVIHALETTENGTNIDGRRFSQEGERLQAANNDTFSKGYAVWVGDRTSLAHGAMIHGPAWIGNDTFVGMEAMIFNAKIGNNVAVGVSSTITGGVVIPDGKFVPPGSVITTQEQADSLPSRIGSPYENTNKAVIHVNENLAEGYDELELEKLAHQREAQMEEGMVETGNNNSSDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MND3</accession>
    <name>A0A075MND3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 11">Adenine phosphoribosyltransferase</fullName>
            <shortName evidence="11">APRT</shortName>
            <ecNumber evidence="6 11">2.4.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">apt</name>
        <name evidence="13" type="ORF">NTE_00643</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 11">Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:16609"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.4.2.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 11">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 11">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.7" evidence="6 11"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MND3"/>
    <dbReference type="STRING" id="1459636.NTE_00643"/>
    <dbReference type="KEGG" id="nev:NTE_00643"/>
    <dbReference type="eggNOG" id="arCOG00030">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063339_3_0_2"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00646"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002055">
        <property type="term" value="F:adenine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003999">
        <property type="term" value="F:adenine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006168">
        <property type="term" value="P:adenine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000021">
        <property type="entry name" value="Adenine phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00004">
        <property type="entry name" value="Aden_phosphoribosyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005764">
        <property type="entry name" value="Ade_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050054">
        <property type="entry name" value="UPRTase/APRTase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002634">
        <property type="entry name" value="PRK02304.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002636">
        <property type="entry name" value="PRK02304.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315:SF3">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 11" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="12">
        <location>
            <begin position="53"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIF82723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="179" mass="19406" checksum="2DA1289D56066BE5" modified="2014-10-29" version="1">MSVVAKLNLNRIIGKHQDFPKPGILFRDINPVFRNPDALKFIATEFSRRFSKTRYDMTAGIESRGFVVATVLGMKAGKGVIMIRKVGKLPGPTIKKSYDIEYGNATMELQIGAVKKGQKVLIADDLIATGGTAVAAAQLVEELGGKVAGFAFVIELAGLKGADRLREMGYKVESLVVYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNN6</accession>
    <name>A0A075MNN6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699718.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNN6"/>
    <dbReference type="GeneID" id="41596597"/>
    <dbReference type="KEGG" id="nev:NTE_00745"/>
    <dbReference type="HOGENOM" id="CLU_1472137_0_0_2"/>
    <dbReference type="OrthoDB" id="375387at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="184" mass="20286" checksum="1A5D5332F2E65DF4" modified="2014-10-29" version="1">MNPVADRAAYAAIGGLLVGLMFLAILGAATSARPWPKYSFSDYVVRQEGPIPPLRLVMVYDYKEYEGLGGNMAWGRDAGSGPMPGHSNFDTGSADYDAKKIVIDLSRNSTVYFEGHDYNGTLQVSTYVYDMENGPWGILDDRGDDGTKKHTFGVNLEPGDYFVTAYAYGKEGYISSFYRIQVIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MP06</accession>
    <name>A0A075MP06_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Core-binding (CB) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NTE_01183</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700051.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MP06"/>
    <dbReference type="STRING" id="1459636.NTE_01183"/>
    <dbReference type="GeneID" id="41596993"/>
    <dbReference type="KEGG" id="nev:NTE_01183"/>
    <dbReference type="eggNOG" id="arCOG01242">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_549387_0_0_2"/>
    <dbReference type="OrthoDB" id="3343at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="5">
        <location>
            <begin position="22"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="388"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF83256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="467" mass="54001" checksum="58FB097CB2D03CB0" modified="2014-10-29" version="1">MPVTLKTVQAKIDEQVRNRTNAKLIHDFDAFMDHNLTSESYRKNNLKAVTYFTAWLSKTSKSKTLLAIKDKEDILNFLKQYRGSPDEEAWKTTYNDYLNRLKHFFRWLHNVRIPGKGPDEVPIEDWKTPDFCKIKKMRTKRKSTYAISETWKREEVLAILPYEPLVRNKAAIAMLWDMDGRNHELCKMMNKHVQYFDNYARAEIPSNTKTGGGPVLLRMSFPYLLAWKNEHPFKDDPNAPLLCNMKGGETLGDPLDPDYLWKITNNLRKSIKAMLASGKIKDEKEAQKLELLLKTKRWNPYCFRHSAIRHDATYLPSYALTQKVRWVPDSKQAGRYMAMTLSEEVEKTILAHDGIITQEAEPAPLNRVCPRCETVNALEFRQCQKCGYALTKKALEEQMAEENNLKERVAQLEVALTNSKQEAVATFLQMWAEYVAPVKGRDLLIGKFPLLTPCQSTTTGEKDKKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MP08</accession>
    <name>A0A075MP08_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00812</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MP08"/>
    <dbReference type="KEGG" id="nev:NTE_00812"/>
    <dbReference type="HOGENOM" id="CLU_1976609_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="126" mass="13896" checksum="189E3999FD818ECD" modified="2014-10-29" version="1">MIISASQHILSIDENILAVCLMDSNFRILEAASKQAFDKKFKIPDKLKKGSGDYAALVFATARLSEETFGKVECIVVDYDMAKTMLLPIQGRGYVGIVVNPSTSTDYITLKVSATIEPNQDIENYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MP12</accession>
    <name>A0A075MP12_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Family 3 adenylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MP12"/>
    <dbReference type="KEGG" id="nev:NTE_00460"/>
    <dbReference type="eggNOG" id="arCOG07810">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089864_0_0_2"/>
    <dbReference type="OrthoDB" id="2830at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="210" mass="23533" checksum="F33BF8849DB9CC3C" modified="2014-10-29" version="1">MMVDMVNSTRTACQLGNSSKLRLFYEIFINTMSRIATRLDARVVKNGGDSIICYFPGTRDCVDKSCLLPVLTCGLEMINARMALNYGLQSIGLPAVSYRISADYGRHEVAKDPYSDTIDLFGPTMSLCAKINSLSPANSLVIGEDLYEIVKTFSDFTITKCGEYRLDEFRSYLLYVVSKGSSKEDDNDVLTGRRDCIIEERTQDKEVLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MP26</accession>
    <name>A0A075MP26_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Large ribosomal subunit protein eL8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">rpl7ae</name>
        <name evidence="11" type="ORF">NTE_01204</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Part of the 50S ribosomal subunit. Probably part of the RNase P complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700068.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MP26"/>
    <dbReference type="STRING" id="1459636.NTE_01204"/>
    <dbReference type="GeneID" id="41597013"/>
    <dbReference type="KEGG" id="nev:NTE_01204"/>
    <dbReference type="eggNOG" id="arCOG01751">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084513_4_0_2"/>
    <dbReference type="OrthoDB" id="25810at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000020">
        <property type="entry name" value="50S ribosomal protein L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00326">
        <property type="entry name" value="Ribosomal_eL8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022481">
        <property type="entry name" value="Ribosomal_eL8_arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03677">
        <property type="entry name" value="eL8_ribo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00884">
        <property type="entry name" value="RIBOSOMALHS6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 9 11" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 9" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="10">
        <location>
            <begin position="18"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIF83276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="127" mass="13638" checksum="9714C0A74D27110E" modified="2014-10-29" version="1">MSKPYFVKFEVSKDLANAAYEAVRVAKQSGKVRKGTNETTKAIERGISKLVVIAEDVEPPEVVAHLPILCEERNASYIFVPSKQQLGMSLGIDVGSAAATIVEAGEAQHIVEQVVNSIAGLKTAKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MP59</accession>
    <name>A0A075MP59_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01251</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700110.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MP59"/>
    <dbReference type="STRING" id="1459636.NTE_01251"/>
    <dbReference type="GeneID" id="41597057"/>
    <dbReference type="KEGG" id="nev:NTE_01251"/>
    <dbReference type="eggNOG" id="arCOG08730">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1405924_0_0_2"/>
    <dbReference type="OrthoDB" id="8020at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="171" mass="20579" checksum="88023A172DA324EB" modified="2014-10-29" version="1">MSSNKPRAITWFKDFMGVGYRYHDVYMNVFPLFQDKMPAFKLWNKSVDWWPDDQIKLRFVEDGDHYWFILYGGSDYKKDNTGFVKKVPMSENYQRFKVGYEKKVMLRFGIYKENTNPKRKERDGSMKKFDLEILKKTKSVYDIAFLQLPELAKDSVEWQCITQQQEENSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPC6</accession>
    <name>A0A075MPC6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Collagen triple helix repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00566</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699574.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPC6"/>
    <dbReference type="GeneID" id="41596431"/>
    <dbReference type="KEGG" id="nev:NTE_00566"/>
    <dbReference type="HOGENOM" id="CLU_1291989_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="182"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="213" mass="22694" checksum="60E065B2B1CB28A9" modified="2014-10-29" version="1">MMWNAISSKNIMLFVAIAAVGLGLLSYATSLQYVIAIPNRGDNDPKNSNKTANDGRDGHPGLNGKGQNGGLGGEGGKGGTAGSSDDDETTAATARTNETKKIMLYERHNPMHRYNETSESYFDSEGNEFVCDEVFNGSIYYKFNETAFFKCDSINSVAGDQSFVTVPTIVTEENATQSESSNNNGQNGQDGQDAINGMDGKDGRDGRDGMDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPE1</accession>
    <name>A0A075MPE1_9ARCH</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01353</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700195.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPE1"/>
    <dbReference type="STRING" id="1459636.NTE_01353"/>
    <dbReference type="GeneID" id="41597151"/>
    <dbReference type="KEGG" id="nev:NTE_01353"/>
    <dbReference type="eggNOG" id="arCOG08760">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_176725_0_0_2"/>
    <dbReference type="OrthoDB" id="8651at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="105" mass="12485" checksum="75117E40C30D3479" modified="2014-10-29" version="1">MQQIDPSDTVKRGRFYFIYDRPPHFVMEDKTKRGLEVREHTLDEKYGVEADRGMIYDMDGIGHKVGIRWYFPKSQHALEQVVAKAEEMEKRYLAIREMTCPDDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPI0</accession>
    <name>A0A075MPI0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative metal-sulfur cluster biosynthetic enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699890.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPI0"/>
    <dbReference type="STRING" id="1459636.NTE_00970"/>
    <dbReference type="GeneID" id="41596800"/>
    <dbReference type="KEGG" id="nev:NTE_00970"/>
    <dbReference type="eggNOG" id="arCOG01845">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG03838">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1323974_0_0_2"/>
    <dbReference type="OrthoDB" id="371709at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1150">
        <property type="entry name" value="Coenzyme PQQ synthesis protein D (PqqD)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="entry name" value="Fe-S cluster assembly (FSCA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052339">
        <property type="entry name" value="Fe-S_Maturation_MIP18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008792">
        <property type="entry name" value="PQQD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041881">
        <property type="entry name" value="PqqD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42831">
        <property type="entry name" value="FE-S PROTEIN MATURATION AUXILIARY FACTOR YITW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42831:SF1">
        <property type="entry name" value="FE-S PROTEIN MATURATION AUXILIARY FACTOR YITW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05402">
        <property type="entry name" value="PqqD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="Fe-S cluster assembly (FSCA) domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIP18 family-like" evidence="1">
        <location>
            <begin position="11"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="202" mass="22655" checksum="F1D1E556842B00C1" modified="2014-10-29" version="1">MSAAAPQQVTKDQVYGALKKCMDPEIPVNVVDLGLIYGVNIADGRNVDIKMTMTTRGCPLHDTLVSDVKRYVGKVPGIGNINVEIVWDPPWSLDKMNPQVREQLGFGKPKLRFQIDYEKAKPMKVGRYTKQEDGSMILANDKDQGFMVNEAIVEFWNTCDGTKTINQLTDQFSAKLGMPRQQVEQEVVQLVQQLLEAELLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPI1</accession>
    <name>A0A075MPI1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cysteine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00627</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699623.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPI1"/>
    <dbReference type="STRING" id="1459636.NTE_00627"/>
    <dbReference type="GeneID" id="41596490"/>
    <dbReference type="KEGG" id="nev:NTE_00627"/>
    <dbReference type="eggNOG" id="arCOG01430">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_435909_0_0_2"/>
    <dbReference type="OrthoDB" id="10138at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="459"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="527" mass="57564" checksum="C7E41A94D27716F2" modified="2014-10-29" version="1">MQGQDEVNNVDDSLLLHFEQEIRSKVPHLGEKPGDAKTAATIINATPLVDITKDLKECAKNVFGLDLADKSLRVFGKFDSDLLAGSIKVRPAVQIIHDAIATGKLKRGQTIFEATSGNFGIALGQISKLGIDVVALVSRKLQEGVFDELRNENTRIINLDMDICPAPGMKGNASLMAAKATASNVRAQLTELGFDPAIFDKSRSEVEAILASQDIINLAKLLAKIYGGFCPEQYDNELNIEVHRTITAAELDQQLREQGVALSESRIVCTFGTGGTSGGLSRYMMEKYGKKSVHVVFPLGDQDVAGIRTKGKASGLKFYEPDRYAGQHEADFRQAKRLLKFFVDKGYDMGESSALALYAVVQMANFGMSDSFIVMIADGIQKYRKSLEAMKEEKQQRSLQVPLQEAVSNIGNYDRVVWIHTMYTPRKEGIELIAKSLGVDESKIFVPTAREVEQLLMTQQVPKEMEKSLGGANAKPLLVCMMGNTSLRVAEVLAQKGIVAESLNGGISALSEGKGKQLPELVRMATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPM1</accession>
    <name>A0A075MPM1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heme/copper-type cytochrome/quinol oxidase, subunit 1</fullName>
            <ecNumber evidence="3">1.9.3.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_01447</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.9.3.1" evidence="3"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPM1"/>
    <dbReference type="STRING" id="1459636.NTE_01447"/>
    <dbReference type="KEGG" id="nev:NTE_01447"/>
    <dbReference type="eggNOG" id="arCOG01237">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011899_7_3_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00919">
        <property type="entry name" value="Heme_Cu_Oxidase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cytochrome c oxidase-like, subunit I domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cyt_c_oxase-like_su1_dom"/>
    </dbReference>
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        <property type="entry name" value="Cyt_c_oxase-like_su1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000883">
        <property type="entry name" value="Cyt_C_Oxase_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10422">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00115">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01165">
        <property type="entry name" value="CYCOXIDASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81442">
        <property type="entry name" value="Cytochrome c oxidase subunit I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50855">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="400"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="442"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome oxidase subunit I profile" evidence="2">
        <location>
            <begin position="1"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF83511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="499" mass="56180" checksum="FDC5D546F0E9688D" modified="2014-10-29" version="1">MWEILFSTHHTDIGLLYIVFSITAVMIGGALAMGIRTELFLPGQQVFPDSTTFHRVFTTHGITMLFLWVLPFGAGVGNYLVPIMVRYKDMAWPKLNAIAFWMIPVAAGLIWLGFADTTWNLYPPYSTTKAPAPAADMLIFGLKILGLSSILGSINFIVTILKMKHPDLPLMKTSLFVWSIFTASLILLVSLPTFTTALIMLYTDRLGVTGFFDPTRGGDPIAYQHLFWFTFHPEVYVFVIPAIGMMYEIIPRFSRKPIFSYQSGVTAFVLLAIVSFASWGHHMFSTGESFTEKTVFMVGTLAAVPASAMHVFNWIATMWGGRVSFKSPMAYVVGGIVTFYLAGAGGVVNTAMPLDFITHDTYWVVGHMHLFLMGIITFAFIAFIYYLFPMMTGRMYNEKAAMIQFWLLFVGVSLTFITQHLMGLYGQPRRVFDYVPTEPLILMNQISTIGAWTIGTSMVLFIANLIHSAMKGRYADMNDPFQLGEVYYDYKRKEPHIEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPN1</accession>
    <name>A0A075MPN1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01457</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385207.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPN1"/>
    <dbReference type="STRING" id="1459636.NTE_01457"/>
    <dbReference type="GeneID" id="43502605"/>
    <dbReference type="KEGG" id="nev:NTE_01457"/>
    <dbReference type="HOGENOM" id="CLU_3003272_0_0_2"/>
    <dbReference type="OrthoDB" id="375740at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="56" mass="6741" checksum="A6164484C13D16F6" modified="2014-10-29" version="1">MAQKGSEDERTRKPAVKHRQYDDKTLENMMRYYNLGENYESLLRYIKRRGLVEGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPR0</accession>
    <name>A0A075MPR0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aspartate ammonia-lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_00759</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPR0"/>
    <dbReference type="STRING" id="1459636.NTE_00759"/>
    <dbReference type="KEGG" id="nev:NTE_00759"/>
    <dbReference type="eggNOG" id="arCOG00842">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG01750">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021594_4_0_2"/>
    <dbReference type="OrthoDB" id="26319at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.40.30:FF:000002">
        <property type="entry name" value="Fumarate hydratase class II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.10:FF:000001">
        <property type="entry name" value="Fumarate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.200.10:FF:000001">
        <property type="entry name" value="Fumarate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051546">
        <property type="entry name" value="Aspartate_Ammonia-Lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018951">
        <property type="entry name" value="Fumarase_C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008909">
        <property type="entry name" value="PRK12273.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42696">
        <property type="entry name" value="ASPARTATE AMMONIA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42696:SF2">
        <property type="entry name" value="ASPARTATE AMMONIA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10415">
        <property type="entry name" value="FumaraseC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00145">
        <property type="entry name" value="ARGSUCLYASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="10"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF82837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="675" mass="75047" checksum="F9E7DF23B24B644E" modified="2014-10-29" version="1">MVLVIEGKRIVLRTPEKSDARSIQENLNDKEVSRYTRIIPYPYTLRHARDFIKIAQQQQQHRRGGSSREEGYSFGIEIKQTHKIIGVISLTRLDCQNRNAEVGYWLGKKYWGRGLAKEALLGILDFGFGDLKLFRIYANVMHPNTASAKLLEKAGFELEGRMRKSVLKDGEWLDELRYSMLEEEYTTGSYSRLDKFKPQERRLIYYGAGAIAVAMSYRIDKDSLGEVKVPSDAYYGPFASRAKEMYKVTGQRAHINLIRAFVMIKRSSALANKELKALDTKKADAIVKACDEILAGKLLDQFVVEAINSGAGTAFNMNSNEVIANRALEILGKKKGEYETVSPNDHVNMSQSSNDTFPTAMHVAILLNMEEADRSLSILINSLRKKAREFEDAIKIGRTHLMDAIPVTLGAEFEEYAYSLARAQKRMRESMDGLREVGLGGTAVGTGANTPKGYRELAIKHLSEVSKLKLKPSDNMFYSLQSKFDVANASSALRNVAIELTKMANDIRLMACGPVAGLAEVLIPAVHAGSSIMPGKVNPSLAECLNMVCFNIIGNDVSVGMAAQAGQFELNVMLPGMLKSMLDSTDMLKNFLPIFAENMIDGIKANREKLESYIEKSPVLVTLLNPYIGYLKAAEIYKEALKTNKSIRELVLEKKLMTKADLDKALSKESILGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPR4</accession>
    <name>A0A075MPR4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD-dependent aldehyde dehydrogenase</fullName>
            <ecNumber evidence="5">1.2.1.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_00764</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.16" evidence="5"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699735.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPR4"/>
    <dbReference type="STRING" id="1459636.NTE_00764"/>
    <dbReference type="GeneID" id="41596615"/>
    <dbReference type="KEGG" id="nev:NTE_00764"/>
    <dbReference type="eggNOG" id="arCOG01252">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_1_0_2"/>
    <dbReference type="OrthoDB" id="6342at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004030">
        <property type="term" value="F:aldehyde dehydrogenase [NAD(P)+] activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07100">
        <property type="entry name" value="ALDH_SSADH1_GabD1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aldehyde dehydrogenase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000012">
        <property type="entry name" value="NAD-dependent succinate-semialdehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044148">
        <property type="entry name" value="ALDH_GabD1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047110">
        <property type="entry name" value="GABD/Sad-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43217">
        <property type="entry name" value="SUCCINATE SEMIALDEHYDE DEHYDROGENASE [NAD(P)+] SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43217:SF1">
        <property type="entry name" value="SUCCINATE SEMIALDEHYDE DEHYDROGENASE [NAD(P)+] SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="4">
        <location>
            <begin position="3"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF82842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="465" mass="51372" checksum="74EA5B03C49AD722" modified="2014-10-29" version="1">MQQQKIETVNPATGKVIASYENDSAEVVAQKVRRAREAFSGWKKLELGERADHMRRLGRVMRKNREEYAHIVTEEMGKPVRQSLAEIEKCAWVCDYYAEHAEAFLRDQIVPTEFRKSFVSFEPLGVVASIMPWNFPFWQVMRFAVPALTAGNVSVLKHSSVCLGSSLKLQEAFSDAGFPENVFQVVVGDYRAGEALVQADIDAVSVTGSVNTGKRVAELASKDLKKFVLELGGSDPFIVLEDADLKQTAYMATQSRLLNTGQSCISAKRFIVVKSIAEKFTKLFVEDTQAEVLGDPLDPKTTIGPLVRDSQRQALARQVDDAKTKGGKVLVGGRPVAGEGYFYEPTIISNVDHEMNVLREEVFGPAAPIIVVEDEEQAVREANNSEFGLGASIWTNNIERGVKLARQIESGIVSVNEMVRSDPRLPFGGVKKSGIGRELSEFGIKEFVNIKSVVVKDIQSKLLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQ15</accession>
    <name>A0A075MQ15_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Succinate dehydrogenase subunit C</fullName>
            <ecNumber evidence="9">1.3.5.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NTE_01593</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="9"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700387.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQ15"/>
    <dbReference type="STRING" id="1459636.NTE_01593"/>
    <dbReference type="GeneID" id="41597373"/>
    <dbReference type="KEGG" id="nev:NTE_01593"/>
    <dbReference type="eggNOG" id="arCOG02244">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_150446_0_0_2"/>
    <dbReference type="OrthoDB" id="5807at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase, transmembrane subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039023">
        <property type="entry name" value="SdhC_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000701">
        <property type="entry name" value="SuccDH_FuR_B_TM-su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41910">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE 2 MEMBRANE SUBUNIT SDHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41910:SF1">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE HYDROPHOBIC MEMBRANE ANCHOR SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01127">
        <property type="entry name" value="Sdh_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fumarate reductase respiratory complex transmembrane subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF83656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="150" mass="16420" checksum="8744D0C5D7A85092" modified="2014-10-29" version="1">METSSSPADRDNREGIAGWLNPSRYGWERVSYWLQRLTGVGLLAYFIGHIYETSNLTGGIDAWNAMLDLTQTPLGHMILILVIGMSTFHSANGIRLIFTHGGKGLGKPGRPDYPYDAVSLNYRQKSGIWIALILAAVAMLYGASVLFGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQ36</accession>
    <name>A0A075MQ36_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00906</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQ36"/>
    <dbReference type="STRING" id="1459636.NTE_00906"/>
    <dbReference type="KEGG" id="nev:NTE_00906"/>
    <dbReference type="HOGENOM" id="CLU_2968268_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="58" mass="6326" checksum="86C85F6F7547A590" modified="2014-10-29" version="1">MVPNYYSSPLLLPSVAEGRGEASAQKNMPQVKAKKKGNTLAVSSMYERQLKTPCTNVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQ42</accession>
    <name>A0A075MQ42_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Precorrin-3B C17-methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.131</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NTE_00916</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.131" evidence="7"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699848.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQ42"/>
    <dbReference type="STRING" id="1459636.NTE_00916"/>
    <dbReference type="GeneID" id="41596752"/>
    <dbReference type="KEGG" id="nev:NTE_00916"/>
    <dbReference type="eggNOG" id="arCOG00647">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047948_2_0_2"/>
    <dbReference type="OrthoDB" id="35891at2157"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030789">
        <property type="term" value="F:precorrin-3B C17-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11646">
        <property type="entry name" value="Precorrin_3B_C17_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="entry name" value="Cobalt-precorrin-4 Transmethylase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="entry name" value="Methyltransferase, Cobalt-precorrin-4 Transmethylase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006363">
        <property type="entry name" value="Cbl_synth_CobJ/CibH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051810">
        <property type="entry name" value="Precorrin_MeTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01466">
        <property type="entry name" value="cobJ_cbiH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47036">
        <property type="entry name" value="COBALT-FACTOR III C(17)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47036:SF1">
        <property type="entry name" value="COBALT-FACTOR III C(17)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="Tetrapyrrole methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tetrapyrrole methylase" evidence="6">
        <location>
            <begin position="10"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF82992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="269" mass="29802" checksum="22E33151CFAA1934" modified="2014-10-29" version="1">MTSEPANKGKLYVVGVGPGHHDHMTYRAKQVIEESEVIVGYETYVGLVEDLIQGKEVYRYAMTQEVDRANQAIGFAEKGRIVSLVSSGDPGIYGMVGLIYEILAEKGWDKDSGIYVECVPGVSSLNSCAALVGSPLMTDFAVVSMSDLLVPWDMIVKRVEAAALGDYVTVIYNPASKKRVHQLRDTRDIFLKYRKPETPVAIIKGAYRETQQVVITTIDEMLEHQDMLGMITTVIVGNSSTYNYKGMMINPRGYTSKYQLVKETPQAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQC5</accession>
    <name>A0A075MQC5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">30S ribosomal protein S9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NTE_01335</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQC5"/>
    <dbReference type="STRING" id="1459636.NTE_01335"/>
    <dbReference type="KEGG" id="nev:NTE_01335"/>
    <dbReference type="eggNOG" id="arCOG04243">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046483_4_0_2"/>
    <dbReference type="OrthoDB" id="52677at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_uS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_uS9_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569:SF16">
        <property type="entry name" value="RIBOSOMAL PROTEIN S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="126"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="98"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="126"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF83403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="155" mass="17069" checksum="D6045AAC4EE0AAB8" modified="2014-10-29" version="1">MEGITIIMTSKIDLYPGQRKTSKAVATIAKGSGKVRINNIPAELVQPEVAKELLLTPLTLVGEQRNKVDINVQVAGGGFMGQAFASAVAISRALTGDVKGDKDPKEHPFPKSIREEIRKKLTEYDRHFLAGDHRQSESKKFGGPGARRRKQKSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQD4</accession>
    <name>A0A075MQD4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQD4"/>
    <dbReference type="KEGG" id="nev:NTE_01018"/>
    <dbReference type="eggNOG" id="arCOG01063">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_160435_0_0_2"/>
    <dbReference type="OrthoDB" id="1242at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038723">
        <property type="entry name" value="ArnR1-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14947">
        <property type="entry name" value="HTH_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ArnR1-like winged helix-turn-helix" evidence="1">
        <location>
            <begin position="12"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="110" mass="12631" checksum="5D73CE473640F610" modified="2014-10-29" version="1">MVPQVTAAVSYRDRIYIVKDILLKLVEYGELNQTALVSFCGLNLKKHKPILEDLELKGLVRRSEKTSGKRTITLYSTTAWGMEFCRTILEPYEKMFPRSRTLHPPAVTSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQI0</accession>
    <name>A0A075MQI0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700122.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQI0"/>
    <dbReference type="GeneID" id="41597071"/>
    <dbReference type="KEGG" id="nev:NTE_01266"/>
    <dbReference type="eggNOG" id="arCOG01055">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_159725_0_0_2"/>
    <dbReference type="OrthoDB" id="140255at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038723">
        <property type="entry name" value="ArnR1-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14947">
        <property type="entry name" value="HTH_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ArnR1-like winged helix-turn-helix" evidence="1">
        <location>
            <begin position="4"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="111" mass="12815" checksum="E5B0486F6AEE8AFB" modified="2014-10-29" version="1">MKFRSRVDIAAEILDAAKDGQLKTRIMYESHTSVKQLNPYLDLLIESELLEYLPEERIYRTTEKGNRFLDGYQKAWHILFYAKSKKASKQEEAVSIVSSRNNNNSSGQNVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQI4</accession>
    <name>A0A075MQI4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ATP dependent helicase, Lhr family</fullName>
            <ecNumber evidence="12">3.6.4.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NTE_01059</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="9">Belongs to the Lhr helicase family. Lhr-Core subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="12"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987181.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQI4"/>
    <dbReference type="STRING" id="1459636.NTE_01059"/>
    <dbReference type="GeneID" id="41596880"/>
    <dbReference type="KEGG" id="nev:NTE_01059"/>
    <dbReference type="eggNOG" id="arCOG00557">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002025_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140097">
        <property type="term" value="F:catalytic activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052511">
        <property type="entry name" value="ATP-dep_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017170">
        <property type="entry name" value="Lhr-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013701">
        <property type="entry name" value="Lhr-like_DEAD/DEAH_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045628">
        <property type="entry name" value="Lhr_WH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47962:SF5">
        <property type="entry name" value="ATP-DEPENDENT HELICASE LHR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47962">
        <property type="entry name" value="ATP-DEPENDENT HELICASE LHR-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08494">
        <property type="entry name" value="DEAD_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19306">
        <property type="entry name" value="WHD_Lhr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037307">
        <property type="entry name" value="Lhr-like_helic_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="38"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="244"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00093467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIF83132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="921" mass="102542" checksum="BE4B9E5192743E11" modified="2014-10-29" version="1">MSTPSVAAEVAVTLDQIIHAKFSKEGFSELTAIQKKALPVISRKINCLLVAPTGSGKTEAAVMPVFSMLSHAKGEMGTIRAIYITPLRALNNDVLRRIVKYAESDGLRVEIRHGDTTAAAKKKIVDNPPDVLITTPESLAVVLTSDKMLAALRGLEYIIVDEVHELVPSERGSHLSISLERLQAASQKHVSRIGLSATVGNLKEAAQFVSGAGRKHAILVDSSARGYDIDVKYVKGSLNNVAHFVVQYVKESKVEGSVLLFTNTRDEAEYLGTILKNQSDIKVDIHHGSLSKEMREETENTLRAGEAGIVVCTSSLELGLDIGSVDLVIHYGSPRQVSKLMQRIGRSRHKQRTFAKGLIVTNNADDEIEALAIINRMKQGSIEEQRMHEGALDAMAHHLVGLAMQTRDPVRVEDAYELVTRAYPFRNVSLFDLESCLDILAAHNVIKYDRESRTYTRKIKAFKYYFENLSMIPHVLKFEVIDTISKRRIGTLDQQFVGDYGERGNVFVLKSSQWRVLSVDEGRMVVNVEPLHGAAINIPYWVGEMIPVDSRTAEQVGSIRSKAAKGAVKLSTDLVQDAAKSLGVIPDSKNVVVESFSARNMLVMHAAFGSKVNNTLASLLSTILSSQLGYIVESRSDAYRIMLTSSARMAKGRIEAALNDVYDLEPVIIASLTGTHQINWKVWMVAKRFGMIAREAVYDKKAARMIYDRYAKTPVSSESIRELVHDKYDIEQARKVLSGIKEGAVKIHWLEVTKFSDLARPIMEHSAKSAAAPQSIEKGVIELVKERLEKTKHRLVCIRCGKWERVMETREAPEEIVCPSCRSKLVTATFWSDYDISKIIQRRLAGGKLLEEENHRFERAWKVASLVNNFGKKALIVLAGHGVGADTAARILRNYIDDDLMYRGIYEAEKQYVITRGFWND</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQK2</accession>
    <name>A0A075MQK2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700513.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQK2"/>
    <dbReference type="STRING" id="1459636.NTE_01750"/>
    <dbReference type="GeneID" id="41597520"/>
    <dbReference type="KEGG" id="nev:NTE_01750"/>
    <dbReference type="eggNOG" id="arCOG00038">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_815348_0_0_2"/>
    <dbReference type="OrthoDB" id="378348at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143437">
        <property type="entry name" value="THUMP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="340" mass="36823" checksum="2D20EAC77562C8DA" modified="2014-10-29" version="1">MTFVLAHPSPQTDAKELAKILRERGAARVEENSFVVLETDRIQEIAGTFGVARVSMAIECESQFAAISKAIAEVGRRTVLQGQGFFVKVHLLTDRDFAARDLEFAATGALAAELAGVASSAKNEEEASAKIVAYVGMRRAFVCLKEYEGAGGAPAGALGSASCAITGPLSLASCIAACKAGFSLPELLLLYGDEDDLCRNAKIARSLAEKTTRAKSQKIAIAKMTAVHPRDGRIRMLQFDLAAARALAGMMKSKNVVLPLSLATHPQWFIEMIMKEIVGAGKVPLVPLMFSEIDYAKEEQDARRVTRQEFMKSKKTALEKPRHVRLEVGPDYLHDIIDSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQK5</accession>
    <name>A0A075MQK5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ferredoxin subunit of nitrite reductase and ring-hydroxylating dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NTE_01296</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700150.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQK5"/>
    <dbReference type="STRING" id="1459636.NTE_01296"/>
    <dbReference type="GeneID" id="41597099"/>
    <dbReference type="KEGG" id="nev:NTE_01296"/>
    <dbReference type="eggNOG" id="arCOG02852">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055690_5_0_2"/>
    <dbReference type="OrthoDB" id="6837at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21496">
        <property type="entry name" value="FERREDOXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21496:SF0">
        <property type="entry name" value="RIESKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="6">
        <location>
            <begin position="4"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF83365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="102" mass="10728" checksum="40C5166F981D0DD6" modified="2014-10-29" version="1">MAKVVVGKASEIGPGQMAHVTAGGKEVLVANIGGVFYAAGNTCNHAGAELHEGTLNGKELTCPWHGAKWDVTTGEMTWFPQKLKPIGSYKVSVENGTVYVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQK9</accession>
    <name>A0A075MQK9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">NTE_01439</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700263.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQK9"/>
    <dbReference type="STRING" id="1459636.NTE_01439"/>
    <dbReference type="GeneID" id="41597234"/>
    <dbReference type="KEGG" id="nev:NTE_01439"/>
    <dbReference type="eggNOG" id="arCOG02358">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG02362">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031353_0_0_2"/>
    <dbReference type="OrthoDB" id="342253at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00075">
        <property type="entry name" value="HATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12912">
        <property type="entry name" value="PDC2_MCP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033479">
        <property type="entry name" value="dCache_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047:SF72">
        <property type="entry name" value="OSMOSENSING HISTIDINE PROTEIN KINASE SLN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02743">
        <property type="entry name" value="dCache_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="12">
        <location>
            <begin position="376"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIF83503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="589" mass="62914" checksum="F2637FBBA0BFBC98" modified="2014-10-29" version="1">MNSWGNIGRPLVIIITVALASMTAVSSFLVYTAQQTAESKIALAASQTLRNNLAGDAQAVSSRVSITLGNAERLLAASALAIAGKDAGSDSVRDTLLLTKSALGPYADNIALISVEGKLLYIASPSTSLPIGSDLSNRRVYELPLATNSPYVSPLLSDLGSVPRFAVAVPVPQSATNGSFNGVLAALVPISSAKNIFLAPYASTDKSLMLVSNDGTILVHPSDGLVGKSITNGTLLGLVSEDTKEMVQQSLQLMSQGKSGVLQYKDRDGNETLMAYEPVLVNGTYVLSVAVSETTSVVQKPFVDVFVESQNFNLLATVLIAAISAIFIAFILVLNRRLFTTVSKQDEKISNQLSELTAAYERLKEQDVIKDEFINIAAHELRTPVLPIVLSAENLADSMPDNDNVRIILRNANRITKLTNDILDASRIESNTFKLQKQKTSIKKLIEEVIQDAQLKIPKGQDVEIVFEAKVPSAMEDLMIDRDRISQVLVNLLDNAINFTESGTIHIVLEPDGEAGRVKVSITDNGKGIDPSVKPKLFGKFVSKSDRAKGTGLGLYLCKAIVESHGGTISGENNAAGTGATFSLTLPMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MR79</accession>
    <name>A0A075MR79_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700718.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MR79"/>
    <dbReference type="STRING" id="1459636.NTE_02014"/>
    <dbReference type="GeneID" id="41597759"/>
    <dbReference type="KEGG" id="nev:NTE_02014"/>
    <dbReference type="eggNOG" id="arCOG12009">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122242_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="191" mass="20930" checksum="21A1849CA60EA59A" modified="2014-10-29" version="1">MTAGTKRSTGETSSEHDVRGQEFDPEEAAEAVKEVAKNIRDTSRTVRKTVTTLDESGAIEEIADAARDTTQDIRDTAEDIQRSGVIEDTAGAIEETTKAASETAEMASGASKKFAAKTPKTTRAVRRGAKKIKKQQGRRTVGRQTRRKMTRKEGAKVDHIARKAKRRVKSVPKGLRGKAAVAKRKGKNRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRC1</accession>
    <name>A0A075MRC1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Streptogramin lyase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01652</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700434.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRC1"/>
    <dbReference type="STRING" id="1459636.NTE_01652"/>
    <dbReference type="GeneID" id="41597427"/>
    <dbReference type="KEGG" id="nev:NTE_01652"/>
    <dbReference type="eggNOG" id="arCOG03564">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_505894_0_0_2"/>
    <dbReference type="OrthoDB" id="12253at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051344">
        <property type="entry name" value="Vgb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40274">
        <property type="entry name" value="VIRGINIAMYCIN B LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40274:SF3">
        <property type="entry name" value="VIRGINIAMYCIN B LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="532" mass="57686" checksum="90C449E9862E805C" modified="2014-10-29" version="1">MSGKRSSPPPSSNKKIIIYAIIGIVAVAGVSATFLAGGTPSGGQQSMSSSQADSIAKFKAQFCGPDPKANSNTYVAEKVLPSECQMPLSLSVDNDGRVWYVSTKQGILGSYSLADNKFAQYQVPQWPVRDNPIEFNMSWATKTDSKGNVWFTDNNELLWRFNTTSGTFDMFKTPATDPISFDFDSDGNIYLVGVRSKSLFFGDLSKMKPGTAEGFTEIKLPLDAFAGIDNFRISSGSVTVDRERNVVWTSVLAFQLKGVIYKYDVEKNQTSLYNLPQELTSPVGMTVDKDGNLWGTDHGTSIFFMLDPSDGKVTEYTTSVASPKIFGGTMPPSAYTLPYWIATAPDGRIWFNQHEGNKISVFDKNTKMLTEYWIPSQNKLWANCPDNASSCGIANALQMSVGPQGQVWFTEWSENKIGTVKTDAQVPFTVSIPNDEVTVKRGDSAEIKVNVNAQGAFNGSAVASGTFTLNGALGNSTGIFSEQNISIPANSSKQVSFVFTPAGDLAPGQYTLMLGAQNDEVSVLKAVRVDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRE6</accession>
    <name>A0A075MRE6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Roadblock/LAMTOR2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01667</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700447.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRE6"/>
    <dbReference type="STRING" id="1459636.NTE_01667"/>
    <dbReference type="GeneID" id="41597442"/>
    <dbReference type="KEGG" id="nev:NTE_01667"/>
    <dbReference type="eggNOG" id="arCOG08684">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128582_2_2_2"/>
    <dbReference type="OrthoDB" id="8852at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="116" mass="13338" checksum="FF202EEEC71FCA3F" modified="2014-10-29" version="1">MSYQKVHHDVMSLDSKIRLVTICDMNGKILFSDHRPGVKNLLTPEESRKSLDLAINAWKTRSELAPKIGKGKYVLAEYEKIKRITMPLDDNHLLYMTTEVDADHSKIIDSISKLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRN0</accession>
    <name>A0A075MRN0_9ARCH</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01659</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700439.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRN0"/>
    <dbReference type="STRING" id="1459636.NTE_01659"/>
    <dbReference type="GeneID" id="41597434"/>
    <dbReference type="KEGG" id="nev:NTE_01659"/>
    <dbReference type="HOGENOM" id="CLU_2190910_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="108" mass="13077" checksum="1123994E43361113" modified="2014-10-29" version="1">MFGKWFRGRVYWKYYNILHQSRNNSYQLPRLYIVRGRVCVQNNEEEEREIEDLLSLGINPRRKTEFNDKNELAELAENLKQALLQDYRMAYSDRGHEYEEEAKSTVNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRQ0</accession>
    <name>A0A075MRQ0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein S30</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_01699</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_075053754.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRQ0"/>
    <dbReference type="STRING" id="1459636.NTE_01699"/>
    <dbReference type="GeneID" id="41597469"/>
    <dbReference type="KEGG" id="nev:NTE_01699"/>
    <dbReference type="eggNOG" id="arCOG04293">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_209471_0_0_2"/>
    <dbReference type="OrthoDB" id="28200at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006846">
        <property type="entry name" value="Ribosomal_eS30"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006817">
        <property type="entry name" value="PRK09336.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04758">
        <property type="entry name" value="Ribosomal_S30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF83760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="60" mass="6926" checksum="610C7A1D2C19937B" modified="2014-10-29" version="1">MPTHGSLTKAGKVRGQTPKIQAKPRSSKIARMRNKDNFVKRFEKKRLPGQKKPERRGGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRQ7</accession>
    <name>A0A075MRQ7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01438</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
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            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRQ7"/>
    <dbReference type="STRING" id="1459636.NTE_01438"/>
    <dbReference type="KEGG" id="nev:NTE_01438"/>
    <dbReference type="HOGENOM" id="CLU_1521799_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="176" mass="18599" checksum="B3C3E5B3E4D2D0AE" modified="2014-10-29" version="1">MTIMTTMILLVCVPAFAQEESGQAAELSLERQVQSQGLFPAAGDYVRYDVTIRNTGPSAIEGRSLWVDFVPMRGGHEGSSAKFEVPLLAPGASAQLHLGPFKLHDAGEYALYVGINRGGDATSPDDLALNTQPDVPLDSVTALDPITAMALPAGMGIAAAGVALLAWLFYARKRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRR5</accession>
    <name>A0A075MRR5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699175.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRR5"/>
    <dbReference type="STRING" id="1459636.NTE_00020"/>
    <dbReference type="GeneID" id="41595974"/>
    <dbReference type="KEGG" id="nev:NTE_00020"/>
    <dbReference type="HOGENOM" id="CLU_2629522_0_0_2"/>
    <dbReference type="OrthoDB" id="373643at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="77" mass="8678" checksum="614808C04887CF80" modified="2014-10-29" version="1">MSISDAGDCKKIEEALKKALNTFDESAVRVLFYHLAEKYRIRFEPPCSSVEEIEAALFDIAGPASDLVISRMRSFLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRR6</accession>
    <name>A0A075MRR6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01448</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700272.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRR6"/>
    <dbReference type="GeneID" id="41597243"/>
    <dbReference type="KEGG" id="nev:NTE_01448"/>
    <dbReference type="eggNOG" id="arCOG08765">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1648361_0_0_2"/>
    <dbReference type="OrthoDB" id="374080at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="173" mass="19304" checksum="71CF84F032299136" modified="2014-10-29" version="1">MLQIAAKKKLPLYVLLGSIAAIAFLVAYVAANGTGEGPVGEAFVNEELPPPGTFPYFLKPITWLMIVVFAGWFSFMELMKNQIKLLDDNWRYFYAMVLFIIVAISFYEILYNFMYWGAILSKQPEAALDPDNVANGFPSQLYQVNIVFATKVGVTIFACAVYALALLKFSGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MS05</accession>
    <name>A0A075MS05_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Small ribosomal subunit protein eS4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rps4e</name>
        <name evidence="10" type="ORF">NTE_01825</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the eukaryotic ribosomal protein eS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700578.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MS05"/>
    <dbReference type="STRING" id="1459636.NTE_01825"/>
    <dbReference type="GeneID" id="41597590"/>
    <dbReference type="KEGG" id="nev:NTE_01825"/>
    <dbReference type="eggNOG" id="arCOG04093">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060400_0_0_2"/>
    <dbReference type="OrthoDB" id="372073at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00485">
        <property type="entry name" value="Ribosomal_eS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000876">
        <property type="entry name" value="Ribosomal_eS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013845">
        <property type="entry name" value="Ribosomal_eS4_central_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038237">
        <property type="entry name" value="Ribosomal_eS4_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013843">
        <property type="entry name" value="Ribosomal_eS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003312">
        <property type="entry name" value="PRK04313.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581">
        <property type="entry name" value="30S/40S RIBOSOMAL PROTEIN S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00900">
        <property type="entry name" value="Ribosomal_S4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08071">
        <property type="entry name" value="RS4NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="KOW" evidence="9">
        <location>
            <begin position="173"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIF83885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="237" mass="25786" checksum="AB2622D5C3A33F7F" modified="2014-10-29" version="1">MGKKGGATRVKRQMAPTFWNIRRKESQFVMRVKPGPHPKNSAYPLGMVLRDAIKVTHTAKESQLILNEGKVKVDGTVRRDPNLAVGLMDVVELANGQAYRLVPKDSELLAPVAVEDAEKAVKLAKITSKVTTKGKKLQYGFHDGKTLLADAKMKVGDTCVLELPGAKVKDHIKFEKGATALIITGENAGKVGKIEDLREGIFSLPTRALVSVGDRTVELPVEMVMVVGKDKPVIKVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MS31</accession>
    <name>A0A075MS31_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MS31"/>
    <dbReference type="STRING" id="1459636.NTE_00127"/>
    <dbReference type="KEGG" id="nev:NTE_00127"/>
    <dbReference type="HOGENOM" id="CLU_3093922_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="51" mass="5614" checksum="60388D1B497E91CE" modified="2014-10-29" version="1">MIVTVATNMELLLAAATAIMIFVATIIVIIVAPVPVRIPRTGIFYMQTIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MS67</accession>
    <name>A0A075MS67_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_02339</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700972.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MS67"/>
    <dbReference type="STRING" id="1459636.NTE_02339"/>
    <dbReference type="GeneID" id="41598055"/>
    <dbReference type="KEGG" id="nev:NTE_02339"/>
    <dbReference type="eggNOG" id="arCOG02037">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_484532_0_0_2"/>
    <dbReference type="OrthoDB" id="30795at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051797">
        <property type="entry name" value="TrmB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002831">
        <property type="entry name" value="Tscrpt_reg_TrmB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34293">
        <property type="entry name" value="HTH-TYPE TRANSCRIPTIONAL REGULATOR TRMBL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34293:SF1">
        <property type="entry name" value="HTH-TYPE TRANSCRIPTIONAL REGULATOR TRMBL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01978">
        <property type="entry name" value="TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription regulator TrmB N-terminal" evidence="2">
        <location>
            <begin position="12"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="80"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF84391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="562" mass="61728" checksum="8119366A4859D704" modified="2014-10-29" version="1">MSLENVTKRFVDLGLSEEEAAVLRDLYLAGESKAGDLARSSGLARIKVYRILDRLQEMSIVESTMGRPVIFSAIPPDSAIERLIEHAARKLETMQVAREEVMKELARFKLQARPQIEAKYRIIQGKQQIYPWIAKMAASAGTEILAYIEREDLRKIYYTDVLEELSKARKRGVKVRILTDVDYSLAATVKDYAGYADIRHTRIPGMSILLVIDESELVVSATTRAEGASDVALWMNGKNFVAGIKGLLGESWENAISAQTRINIMKEGGKALQDILIVRGTQSIGEFYKGMLSRAKKKVLHVSVPYDTEFFGPLASDALAWAGRKVDMQVLTAIDNSSLGDVKDLGGNKCKVRHIDAKAGVNITIVDGEEVMLTPAAGGAKSRSQSAIWSNVRDYVEHYRIMFDNLWSSSSTEMADRIALVEAQAKAEEMALQMRRTLESAGFKIQKAIKGTSGLVHEFSIVAAAGEHDAAAAAVVVDIAGIEKPDLQTAVIGFVVKCMDIKADHKLLVTLFDPAQVQAPARSLNSDITIASAQDAEKTLRKMLGMKQQPKQQQITTTALID</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSA0</accession>
    <name>A0A075MSA0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Coenzyme PQQ synthesis protein D (PqqD)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01619</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700409.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSA0"/>
    <dbReference type="GeneID" id="41597398"/>
    <dbReference type="KEGG" id="nev:NTE_01619"/>
    <dbReference type="eggNOG" id="arCOG03838">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2379505_0_0_2"/>
    <dbReference type="OrthoDB" id="9125at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008792">
        <property type="entry name" value="PQQD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05402">
        <property type="entry name" value="PqqD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="92" mass="10316" checksum="A29F97748F53335D" modified="2014-10-29" version="1">MVGNDQDGTPLLINGRGEAYRVNDTAVSLWNMCNGITFEDLYLEVLRISSGDEDDVRKSLEKMVKQFHKISVVEMKETGIPPSADRRPGMQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSA2</accession>
    <name>A0A075MSA2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00147</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSA2"/>
    <dbReference type="STRING" id="1459636.NTE_00147"/>
    <dbReference type="GeneID" id="41596086"/>
    <dbReference type="KEGG" id="nev:NTE_00147"/>
    <dbReference type="eggNOG" id="arCOG08805">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100103_1_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="179" mass="20519" checksum="7763780B4761442A" modified="2014-10-29" version="1">MISNSKEETETKTFRVKSSVLDQLKREAEEEGISLNSLVHKAFMQYIWCNTKTAKGMMVPVSKARLRVIMEKMTEEEIIEVSQANSKTDPKALQFILHGEYSEDALIESLEIWSIASRFTFSKKRTQDNKIQLLVHHNMGYKCSLFFCKTIAEAIHNATGNRPQYNISDNFFALTVVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSW3</accession>
    <name>A0A075MSW3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSW3"/>
    <dbReference type="GeneID" id="75933626"/>
    <dbReference type="KEGG" id="nev:NTE_02201"/>
    <dbReference type="HOGENOM" id="CLU_219264_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="40" mass="4728" checksum="073F93D0A093722A" modified="2014-10-29" version="1">MSSSSNKDAEREETNEEVHEVEDQEQDEEEEEEEVEEGEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSY1</accession>
    <name>A0A075MSY1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative hydrolase or acyltransferase of alpha/beta superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_02236</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700893.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSY1"/>
    <dbReference type="STRING" id="1459636.NTE_02236"/>
    <dbReference type="GeneID" id="41597956"/>
    <dbReference type="KEGG" id="nev:NTE_02236"/>
    <dbReference type="eggNOG" id="arCOG01648">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_12_3_2"/>
    <dbReference type="OrthoDB" id="111592at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF31">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN YCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="25"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF84290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="285" mass="32308" checksum="0F99E01F8A9C2A1A" modified="2014-10-29" version="1">MSLVKVNDEVSLYVEDTRKGTGGKPTIVFIHGWPSHGMFEYQFMQLQKKGYRCIGMDLRGFGRSDKPWYGEYTYDTFADDIEDVMTALDLHGVTLVGFSMGGAIAMHHAAKYLSSGRISKVIFMGAAAPCFTKREDFPYGLDKSDCDSLIAQSLNDRAKMVHDFIKIFFRSEDSQSQETRNWLFAINMQASPYATVKCLEELRDADLRDDMRKISERKLPVAIFHGVNDKICPFDLANVMNRGIEGSRLVRFENSGHGLNIEEKEKANDELIKFVDLEVPKQTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MT14</accession>
    <name>A0A075MT14_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nitrogen regulatory protein PII</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02292</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_075054098.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MT14"/>
    <dbReference type="STRING" id="1459636.NTE_02292"/>
    <dbReference type="GeneID" id="41598007"/>
    <dbReference type="KEGG" id="nev:NTE_02292"/>
    <dbReference type="eggNOG" id="arCOG02305">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082268_0_1_2"/>
    <dbReference type="OrthoDB" id="10960at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006808">
        <property type="term" value="P:regulation of nitrogen utilization"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002187">
        <property type="entry name" value="N-reg_PII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30115">
        <property type="entry name" value="NITROGEN REGULATORY PROTEIN P-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30115:SF11">
        <property type="entry name" value="NITROGEN REGULATORY PROTEIN P-II HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00543">
        <property type="entry name" value="P-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00340">
        <property type="entry name" value="PIIGLNB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00938">
        <property type="entry name" value="P-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="GlnB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51343">
        <property type="entry name" value="PII_GLNB_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="113" mass="12615" checksum="FC032A37AA75A66C" modified="2014-10-29" version="1">MKKLEAIIRSEKMPVVKEKLRQLGIGGMTIYNVSGWSKQRELHLQWRGQPVAYDLLPKIKFEILVPDAQLDQVIQAVVESSRTGEHGDGVIFVSTVEQAINIATLDKGDKSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MT28</accession>
    <name>A0A075MT28_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Lipid-A-disaccharide synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02312</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700948.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MT28"/>
    <dbReference type="STRING" id="1459636.NTE_02312"/>
    <dbReference type="GeneID" id="41598028"/>
    <dbReference type="KEGG" id="nev:NTE_02312"/>
    <dbReference type="eggNOG" id="arCOG01395">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067068_0_0_2"/>
    <dbReference type="OrthoDB" id="185087at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007152">
        <property type="entry name" value="DUF354"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39662:SF1">
        <property type="entry name" value="DUF354 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39662">
        <property type="entry name" value="DUF354 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04007">
        <property type="entry name" value="DUF354"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005357">
        <property type="entry name" value="UCP005357"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="362" mass="39687" checksum="961C79D950250E93" modified="2014-10-29" version="1">MRIWFDVLTPKQVMFFKDAVKSLQEKGHEVLCTSRDYREAVELARIKGLDLKLVGRHGGPERYGKLAASAERMRALADVISGFAPDAAVTFSSPEGARVAFGLGVRHIGFNDSPHAEAVAKLTVPLMSRLLCPWVIPYSSWTGFGISRKDISRYHALDPAAWLKDDNDDSSSSAHMVEPDKKEGNKTVVLIRLEESKASYIADKKLASTALVDAVVDELAQRADIVMLCRYSDQIEEAKARYGNSARIIESVVDGVSLIKSTDLFIGAGGTMSAEAALLGVPTISIAPVRYHVEDYLVRSGLVARTRNPGALAKLASRMLAGEKFRKAQKKRAERALASMENPTKKMLAAILLKQNNDHHKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MT54</accession>
    <name>A0A075MT54_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02244</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MT54"/>
    <dbReference type="KEGG" id="nev:NTE_02244"/>
    <dbReference type="HOGENOM" id="CLU_156997_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="90" mass="10553" checksum="7C190F73EAD16D6D" modified="2014-10-29" version="1">MQKTVVKYVKGLSETASAFEKRNHKKYGGLNHICRQIEYDVKHGVTEKEVVRMLRKVHDDSSFSELRKGNGSMQRLEEIESRFIKPRIVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTH3</accession>
    <name>A0A075MTH3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_02356</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700988.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTH3"/>
    <dbReference type="STRING" id="1459636.NTE_02356"/>
    <dbReference type="GeneID" id="41598072"/>
    <dbReference type="KEGG" id="nev:NTE_02356"/>
    <dbReference type="eggNOG" id="arCOG02396">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_560980_0_0_2"/>
    <dbReference type="OrthoDB" id="12035at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="485"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="487"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF84408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="509" mass="54416" checksum="AB411E3D51956D43" modified="2014-10-29" version="1">MVFPSNFFLKLKPSSSSASRLKISGAGFRGMIAGAATGAFYVAANFMIPEHFAFGKFDPAYITSPDNAASAVVLFCPAIAGAAGFVLPPHIKNILQIFKIVPRRGEATMASGSATAEAATAAPSAAAGQQAVEVVTAAPASAAQEQASAQLAPPPPLQAPNNNSMEDTVAMIEDMVTKKVGEVVTDVTSMKNEVASFRDDISKLKGDIQNLTLSFESSLTDLKAFQAEMVNPLNFMRKYFETMDIKNLSDPIQGLPHVELPAAKVQGQKKEEQTAAVEEQKPKVHDNDDDKQQTDIIPAEKKPLAGYERGDDDSDVATSKASLEKLLQQQATAEARDGEATFQQQHQHLLSQAEKLGDEVSMVTGYYKQGNENGNGNGNGNGNGHANPLFQGNLTLGKLMSMVSILDKLLCDMGPDELEALIEQYRQFGLKAEDEAAIYKVVGMLKDFGMSADEAMIRLYRLGQIMGIKDAQADLEYAKLKARSKSAKNAPAAAAAASRAGTYRRNADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTH6</accession>
    <name>A0A075MTH6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Lysine--tRNA ligase</fullName>
            <ecNumber evidence="10">6.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Lysyl-tRNA synthetase</fullName>
            <shortName evidence="10">LysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">lysS</name>
        <name evidence="11" type="ORF">NTE_02878</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>tRNA(Lys) + L-lysine + ATP = L-lysyl-tRNA(Lys) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.6" evidence="10"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701408.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTH6"/>
    <dbReference type="STRING" id="1459636.NTE_02878"/>
    <dbReference type="GeneID" id="41598558"/>
    <dbReference type="KEGG" id="nev:NTE_02878"/>
    <dbReference type="eggNOG" id="arCOG00485">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025562_1_0_2"/>
    <dbReference type="OrthoDB" id="6838at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00177">
        <property type="entry name" value="Lys_tRNA_synth_class1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020751">
        <property type="entry name" value="aa-tRNA-synth_I_codon-bd_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008925">
        <property type="entry name" value="aa_tRNA-synth_I_cd-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002904">
        <property type="entry name" value="Lys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00467">
        <property type="entry name" value="lysS_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37940">
        <property type="entry name" value="LYSINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37940:SF1">
        <property type="entry name" value="LYSINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01921">
        <property type="entry name" value="tRNA-synt_1f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48163">
        <property type="entry name" value="An anticodon-binding domain of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="short sequence motif" description="'HIGH' region" evidence="10">
        <location>
            <begin position="48"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="10">
        <location>
            <begin position="304"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIF84916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="548" mass="61386" checksum="C23DAF3348CD6E70" modified="2014-10-29" version="1">MKEEDNHNHQSVIGKGTWLDKVADTLIKREKKLGRKLDLIRVESGLGASGIPHIGSMGDAVRAYGIALALQNMGYKAELIAYSDDMDGLRKIPAGLPDWLKEHIARPVSEIPDPFGNCHASYGAHMSSLLLDGLDGAGIKYRFQSGREAYKSGKLVSQIDRILQSSEKLGKKIAEFVGQDKYVSVLPYFPVCSSCGRLYTAAAEKYMPDEKKVTYACKGSRIGKNEVAGCGHKGEADITKGEGKLAWKVEFAARWQAFDVRFEAYGKDIMDSVRVNDWVCDEILGHPHPLHVKYEMFLDKSGKKISKSAGNVLTPQMWLRYGTPESILLLLFKRIAGTHHVGLEDVPALMDEYDSYEGLYFGKVKEDNQAKLTKIKGIYEYINKLNPPKQPAPHAPYHFLVQQASIYPSDPDRLEKVFARLGKYGMVKEKSDAIMRKIQLAANWADDNASRVGDEKFEVQLTDNQRKAVTELIGVMNEEFAGVQETPENAKALQSRVFDIARANGMEPKEFFTLLYRMFLNADRGPRIGNYFLDLGAERVSSVLKRYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTM0</accession>
    <name>A0A075MTM0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00553</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699564.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTM0"/>
    <dbReference type="STRING" id="1459636.NTE_00553"/>
    <dbReference type="GeneID" id="41596421"/>
    <dbReference type="KEGG" id="nev:NTE_00553"/>
    <dbReference type="HOGENOM" id="CLU_2678683_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="74" mass="8492" checksum="698A1488CA1AFC69" modified="2014-10-29" version="1">MSTPTNEEFQAAKIGIEVIIRHVSHHADFRGQIMRLDKNAQFARITFQTSLPSSDLIFGALYFASIDRFYTEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTM2</accession>
    <name>A0A075MTM2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Plastocyanin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NTE_02491</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="5">Binds 1 copper ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701097.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTM2"/>
    <dbReference type="STRING" id="1459636.NTE_02491"/>
    <dbReference type="GeneID" id="41598195"/>
    <dbReference type="KEGG" id="nev:NTE_02491"/>
    <dbReference type="eggNOG" id="arCOG02929">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084115_4_0_2"/>
    <dbReference type="OrthoDB" id="11836at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13921">
        <property type="entry name" value="Amicyanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035668">
        <property type="entry name" value="Amicyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002386">
        <property type="entry name" value="Amicyanin/Pseudoazurin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028096">
        <property type="entry name" value="EfeO_Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052721">
        <property type="entry name" value="ET_Amicyanin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36507">
        <property type="entry name" value="BLL1555 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36507:SF1">
        <property type="entry name" value="BLL1555 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13473">
        <property type="entry name" value="Cupredoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00155">
        <property type="entry name" value="AMICYANIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0574">Periplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="EfeO-type cupredoxin-like" evidence="6">
        <location>
            <begin position="66"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602386-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF84540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="146" mass="15365" checksum="14AD34DDF8EE547A" modified="2014-10-29" version="1">MVWKIVILSIAIVIASFIIAGAIVAAQVLGNNIPDGIGQQQAKDSRQQGLPPAAINGTKVSIVDNSKSNSYSPNPVRVKAGDTVTWVNDDSATHTATSRDGAFDSNPLKRGEVFSHTFDKEGEYPYFCAIHPNMVGTVVVVAPSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTN1</accession>
    <name>A0A075MTN1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02443</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701060.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTN1"/>
    <dbReference type="STRING" id="1459636.NTE_02443"/>
    <dbReference type="GeneID" id="41598151"/>
    <dbReference type="KEGG" id="nev:NTE_02443"/>
    <dbReference type="eggNOG" id="arCOG02751">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_942435_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:DNA transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase IS4-like" evidence="1">
        <location>
            <begin position="137"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="334" mass="39042" checksum="535C2FFFA5C34514" modified="2014-10-29" version="1">MACKHKRKDGYWQYYHLAHTLERDMLVKNIASLVMENPPLRPEKKKSGKGKKPVHSWEKLVCICILMVVFGSTYRDMQNMVPSLNLPWKNNEPYPDHTWIARTFKKIPIKYLDDILVRSAYLCLKESGWKKGILGSDSTGVETDRYEKEVRPVRKKRKFEVVRVKRYLKWHVTAVLDHLVILTVRTTSKKTHDSPVLRTMLNKLKKYGVDLAGSIFNADRGYDAEDNCKSVFGMDMLPNIKQKINARNKGERMKYRRKASKLFNVSVYHYRGLIEGIFGAEETEHHQLYCRFRLKNNQKRFGIIKAIGWNMEVLNRMQCANKLGIKVGQYAISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTR6</accession>
    <name>A0A075MTR6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase family protein associated with various cellular activities (AAA)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00598</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699600.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTR6"/>
    <dbReference type="STRING" id="1459636.NTE_00598"/>
    <dbReference type="GeneID" id="41596461"/>
    <dbReference type="KEGG" id="nev:NTE_00598"/>
    <dbReference type="eggNOG" id="arCOG00441">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1044353_0_0_2"/>
    <dbReference type="OrthoDB" id="9837at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050764">
        <property type="entry name" value="CbbQ/NirQ/NorQ/GpvN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42759:SF1">
        <property type="entry name" value="MAGNESIUM-CHELATASE SUBUNIT CHLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42759">
        <property type="entry name" value="MOXR FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="1">
        <location>
            <begin position="34"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="281" mass="31598" checksum="4E97E8F7D8417142" modified="2014-10-29" version="1">MATTELDNNGSSSQEVIYLDWNNALDVLEKAYKAGLFVLIIGPKGTGKTTLVRKFASAMEKELYSVNFSLRTRESHLVGTRTIDKGQINFVEGVLVKSMKEGTMLYLDELNAAEADVLLRLDEALDDRRQLVLKEAEGQLVKASPDWFVIATINPLSHVGTKELPPQLLSRFPVRMRLDYPPEDLELEIVKRHVKMDNDDGKMRDVKHAIQLARSLRDAAAVEELYYSPSLRETIAFAKMLNAGLSGRQAAEVVYANAYDQWGQVEYQKVLDMITSIFGDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTU1</accession>
    <name>A0A075MTU1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TIGR00162 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700804.1">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PAC-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004426">
        <property type="entry name" value="MJ1210-like"/>
    </dbReference>
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        <property type="entry name" value="Proteasome_assmbl_chaperone_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038389">
        <property type="entry name" value="PSMG2_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00162">
        <property type="entry name" value="proteasome assembly chaperone family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35610:SF7">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35610">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09754">
        <property type="entry name" value="PAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159659">
        <property type="entry name" value="Cgl1923-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="247"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="265" mass="28350" checksum="821323F4F47DB019" modified="2014-10-29" version="1">MPAGEIQFVYSAKEMPKFATEPRLVCGFPGSGYVGKLAIDHLIQELHATHLADIYSSSFPPQVMIRTDGTADLMKNSIFSWQGKETSLLLLTGDSQPSDPDSEYALAEHILDFGAQFGAKQVFTLAAYITGVFVDKPRVFGTATDASLVGNFASHGVSLMDSGSITGMNGLVIGIAKLRGIKGTCLLGETSGYVVDAKASKAVLETLLSIIGINVDMSNLEKRAKDTEMLIQTIEQQMAAGRGGLAQEGQQQQQPQKPRNTGYIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTV8</accession>
    <name>A0A075MTV8_9ARCH</name>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">NTE_02531</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
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            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385488.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTV8"/>
    <dbReference type="GeneID" id="43502651"/>
    <dbReference type="KEGG" id="nev:NTE_02531"/>
    <dbReference type="HOGENOM" id="CLU_3093926_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="51" mass="6007" checksum="63BAD017579A2AC9" modified="2014-10-29" version="1">MSEEDPRRTALYQRLQVLGVNVSKIKDMEITLEALLELTERLEEIIQTDKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTX0</accession>
    <name>A0A075MTX0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-type polysaccharide/polyol phosphate export systems, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NTE_03061</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701558.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTX0"/>
    <dbReference type="STRING" id="1459636.NTE_03061"/>
    <dbReference type="GeneID" id="41598728"/>
    <dbReference type="KEGG" id="nev:NTE_03061"/>
    <dbReference type="eggNOG" id="arCOG01467">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039483_2_3_2"/>
    <dbReference type="OrthoDB" id="147058at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047817">
        <property type="entry name" value="ABC2_TM_bact-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051784">
        <property type="entry name" value="Nod_factor_ABC_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43229">
        <property type="entry name" value="NODULATION PROTEIN J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43229:SF2">
        <property type="entry name" value="NODULATION PROTEIN J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00164">
        <property type="entry name" value="ABC2TRNSPORT"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-2" evidence="6">
        <location>
            <begin position="29"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF85096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="259" mass="27896" checksum="FDF8FDBAE4CF7383" modified="2014-10-29" version="1">MMIEEVQTHVAKVYAIWLREFKVFLREKSRLVASTFTPILWLFVIGSGIGSATTVSAAPSLDYQQFIFPGIVSMSIIFTSVFYGSYIIWDRKFDFLKSVMVAPVSRGAVFVGKTLGGMTNSLVQALILLAIGAAIGIPLTPLSVVQAVAVIMLMSFGLTSLGLALGSYMYSLEGFQMIVSFVVFPLFFLSGALFPLDNLPAWLSVLTAIDPATYGVSAMRGTMLGVGSANPALDFAILTAYTGALGLFGIYSFKRMKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MU45</accession>
    <name>A0A075MU45_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00746</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MU45"/>
    <dbReference type="KEGG" id="nev:NTE_00746"/>
    <dbReference type="eggNOG" id="arCOG14335">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1631561_0_0_2"/>
    <dbReference type="OrthoDB" id="3301at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="184" mass="21489" checksum="61B11633346638C3" modified="2014-10-29" version="1">MTISLVLTFAMMMTMTTTTFYFQSVNADECAEDKDWPEKPCPAYGAASEAELRERWDKYYEMKGKEWMEAKKAEMDQAIKNNTFTEWIQYGDLDNNNAANRNAYFYYRLNNQVPLRVRDFEGRYFMPEEQDPSMFIFTPLSGDYYVKPPPAPWYTRPEGLYVIIGIGSASALASFFALRKVIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUC0</accession>
    <name>A0A075MUC0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Asparagine synthase (Glutamine-hydrolyzing)</fullName>
            <ecNumber evidence="4">6.3.5.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_00858</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.3.5.4" evidence="4"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699804.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUC0"/>
    <dbReference type="STRING" id="1459636.NTE_00858"/>
    <dbReference type="GeneID" id="41596701"/>
    <dbReference type="KEGG" id="nev:NTE_00858"/>
    <dbReference type="eggNOG" id="arCOG00071">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1063970_0_0_2"/>
    <dbReference type="OrthoDB" id="8692at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050795">
        <property type="entry name" value="Asn_Synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11772">
        <property type="entry name" value="ASPARAGINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11772:SF2">
        <property type="entry name" value="ASPARAGINE SYNTHETASE [GLUTAMINE-HYDROLYZING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asparagine synthetase" evidence="3">
        <location>
            <begin position="12"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Asparagine synthetase" evidence="3">
        <location>
            <begin position="167"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF82934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="265" mass="29100" checksum="AA6BF4F8A35BFE6F" modified="2014-10-29" version="1">MSLLRQELECALHDIVRAVLPEKNVAVAFSGGVDSTLLAVICRDLGKQVTLVTVGFPDSHDVSFSKEIASKIGLPHKVVELDSLDFKKDLAHVLQTITCGNTSHIENCIAYYYIAQAAGKLGLSVVASANGCDELFCGYNGYRAVYDKGESAIMEYMESKIKNELVLVQEISAVAAEFSVQVRQPFLSTEFVEFAKKVPIDQKIRGANDMVRKHILRQAALSLGVPEESALKPKKALQYGSYIHKNYKKSPSARTDGKEMKKSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUG2</accession>
    <name>A0A075MUG2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02284</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700931.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUG2"/>
    <dbReference type="STRING" id="1459636.NTE_02284"/>
    <dbReference type="GeneID" id="41597999"/>
    <dbReference type="KEGG" id="nev:NTE_02284"/>
    <dbReference type="eggNOG" id="arCOG08652">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1998647_0_0_2"/>
    <dbReference type="OrthoDB" id="5664at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="131" mass="15274" checksum="6726CC6DC7001DAF" modified="2014-10-29" version="1">MDDFEKEYPGFDWKNTPAYKHPGGKDCPCPKHEYIREQMRVAQTVSESNKDLPPEQRQQGKITLKFCPDHYDVYFNEVIPAMPFKYRFMTKVALKIGAISIQKLTYMQSDQCFYCKFGSGGFDKKTELPPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUG5</accession>
    <name>A0A075MUG5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 6">RNA 3'-terminal phosphate cyclase</fullName>
            <shortName evidence="5">RNA cyclase</shortName>
            <shortName evidence="5">RNA-3'-phosphate cyclase</shortName>
            <ecNumber evidence="5 6">6.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rtcA</name>
        <name evidence="9" type="ORF">NTE_02716</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3'-end 3'-phospho-ribonucleotide-RNA + ATP = a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23976"/>
            <dbReference type="Rhea" id="RHEA-COMP:10463"/>
            <dbReference type="Rhea" id="RHEA-COMP:10464"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:83062"/>
            <dbReference type="ChEBI" id="CHEBI:83064"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.5.1.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.4" evidence="5 6"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701274.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUG5"/>
    <dbReference type="STRING" id="1459636.NTE_02716"/>
    <dbReference type="GeneID" id="41598406"/>
    <dbReference type="KEGG" id="nev:NTE_02716"/>
    <dbReference type="eggNOG" id="arCOG04125">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027882_0_0_2"/>
    <dbReference type="OrthoDB" id="7994at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003963">
        <property type="term" value="F:RNA-3'-phosphate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00200">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013791">
        <property type="entry name" value="RNA3'-term_phos_cycl_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023797">
        <property type="entry name" value="RNA3'_phos_cyclase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037136">
        <property type="entry name" value="RNA3'_phos_cyclase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000228">
        <property type="entry name" value="RNA3'_term_phos_cyc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017770">
        <property type="entry name" value="RNA3'_term_phos_cyc_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020719">
        <property type="entry name" value="RNA3'_term_phos_cycl-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036553">
        <property type="entry name" value="RPTC_insert"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03399">
        <property type="entry name" value="RNA_3prim_cycl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096">
        <property type="entry name" value="RNA 3' TERMINAL PHOSPHATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096:SF0">
        <property type="entry name" value="RNA 3'-TERMINAL PHOSPHATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01137">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05189">
        <property type="entry name" value="RTC_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005378">
        <property type="entry name" value="RNA3'_term_phos_cycl_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="EPT/RTPC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52913">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase, RPTC, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01287">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase" evidence="7">
        <location>
            <begin position="14"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase insert" evidence="8">
        <location>
            <begin position="189"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="5">
        <location>
            <position position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="NCBIfam" id="TIGR03399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF84758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="354" mass="37038" checksum="CED26B4976BF111B" modified="2014-10-29" version="1">MKPPTIIKIDGSQGEGGGQILRTAISLSAVTGTPVEITGIRAKRENPGLRPSHLAAVKVVADLFGAKVENLQVGADWVRFSPAKGKFAGGPCKVDIGTAGSISLTLMAAIPAVSLSGNSLEIEITGGTDVRASPTIDYLRYVVSEAYRSVGIKFSLDVLKRGYYPKGGGIVKATIEPCGEPAPAEFVNGRAVAPRITSVCSQLPKHVAERQISSALLSLEKSGVKCTNYTASFETALSPGTSVLVYSVSDFGGPFVGGDSIGEVGKRAEQVGQEAAARYLESTLAEAAVDPFLADMLVLPLCLAKGVSRYRTSKVTEHLRTNLQVASQIVAGCRYNIAQPPGKNESVITIEGAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUK6</accession>
    <name>A0A075MUK6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nitrogen regulatory protein PII</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02867</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701399.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUK6"/>
    <dbReference type="STRING" id="1459636.NTE_02867"/>
    <dbReference type="GeneID" id="41598549"/>
    <dbReference type="KEGG" id="nev:NTE_02867"/>
    <dbReference type="eggNOG" id="arCOG02305">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082268_3_0_2"/>
    <dbReference type="OrthoDB" id="10960at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006808">
        <property type="term" value="P:regulation of nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002187">
        <property type="entry name" value="N-reg_PII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30115">
        <property type="entry name" value="NITROGEN REGULATORY PROTEIN P-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30115:SF11">
        <property type="entry name" value="NITROGEN REGULATORY PROTEIN P-II HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00543">
        <property type="entry name" value="P-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00340">
        <property type="entry name" value="PIIGLNB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00938">
        <property type="entry name" value="P-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="GlnB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51343">
        <property type="entry name" value="PII_GLNB_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="114" mass="12448" checksum="93AD3DDD5EF4D549" modified="2014-10-29" version="1">MKKIEAVVPHARVERAFAALKELDLGGITYFESKGRGEIPRPKIHSGRGTGTYTPEFNVNSTIMVVVKDSMVEKVIEKILESTSSGLKGEGKIFISEIEDVIDVGTKKRGESAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUN8</accession>
    <name>A0A075MUN8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_00948</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUN8"/>
    <dbReference type="STRING" id="1459636.NTE_00948"/>
    <dbReference type="KEGG" id="nev:NTE_00948"/>
    <dbReference type="eggNOG" id="arCOG03177">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083287_18_2_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42756">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR, MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42756:SF1">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR OF EMRAB OPERON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH marR-type" evidence="4">
        <location>
            <begin position="6"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF83024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="160" mass="18056" checksum="B5D5729377904395" modified="2014-10-29" version="1">MQKNIQANLGLTFKNAVIMMQKAFDFDLRKNVGINWSQAKVIMTLAQKNGVAQKEIADGICIEAPTLVPIIDKMEREGLVERRQDMADRRNNRVYLTDRSRSLQNAIDESIARVRKVAYKGITKGDLETTMEVLETITKNASDYLESQAPVAEVQKAARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUP7</accession>
    <name>A0A075MUP7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable chemoreceptor glutamine deamidase CheD</fullName>
            <ecNumber evidence="3">3.5.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cheD</name>
        <name evidence="4" type="ORF">NTE_02350</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-glutaminyl-[protein] + H2O = L-glutamyl-[protein] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16441"/>
            <dbReference type="Rhea" id="RHEA-COMP:10207"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="EC" id="3.5.1.44"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CheD family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.44" evidence="3"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700983.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUP7"/>
    <dbReference type="STRING" id="1459636.NTE_02350"/>
    <dbReference type="GeneID" id="41598066"/>
    <dbReference type="KEGG" id="nev:NTE_02350"/>
    <dbReference type="eggNOG" id="arCOG02380">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087854_2_0_2"/>
    <dbReference type="OrthoDB" id="10499at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050568">
        <property type="term" value="F:protein-glutamine glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16352">
        <property type="entry name" value="CheD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01440">
        <property type="entry name" value="CheD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038592">
        <property type="entry name" value="CheD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005659">
        <property type="entry name" value="Chemorcpt_Glu_NH3ase_CheD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011324">
        <property type="entry name" value="Cytotoxic_necrot_fac-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35147">
        <property type="entry name" value="CHEMORECEPTOR GLUTAMINE DEAMIDASE CHED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35147:SF1">
        <property type="entry name" value="CHEMORECEPTOR GLUTAMINE DEAMIDASE CHED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03975">
        <property type="entry name" value="CheD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64438">
        <property type="entry name" value="CNF1/YfiH-like putative cysteine hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="2 3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF84402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="169" mass="18204" checksum="900D23A9383FFBF9" modified="2014-10-29" version="1">MDAETSVGMGELYVADKKDTVLTTFVGSCIALCLYDPRSKVGGMAHIMLPENGSRNSYNDSPSSADESAKYADEALENTLRMMVEKGALPGRLVAKIAGGAKIFSHEGSSDDMFSIGSRNTESIKRLLTQKGIKIAGEDVGLNHGRWVRFNLNSGRVVVSMRNSGEKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUR5</accession>
    <name>A0A075MUR5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Urease, gamma subunit</fullName>
            <ecNumber evidence="3">3.5.1.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_02912</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.1.5" evidence="3"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701436.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUR5"/>
    <dbReference type="STRING" id="1459636.NTE_02912"/>
    <dbReference type="GeneID" id="41598590"/>
    <dbReference type="KEGG" id="nev:NTE_02912"/>
    <dbReference type="eggNOG" id="arCOG04528">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_145825_1_0_2"/>
    <dbReference type="OrthoDB" id="42431at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009039">
        <property type="term" value="F:urease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00390">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.280.10">
        <property type="entry name" value="Urease, gamma-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00739">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012010">
        <property type="entry name" value="Urease_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002026">
        <property type="entry name" value="Urease_gamma/gamma-beta_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036463">
        <property type="entry name" value="Urease_gamma_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050069">
        <property type="entry name" value="Urease_subunit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009712">
        <property type="entry name" value="PRK13241.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00193">
        <property type="entry name" value="urease_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33569">
        <property type="entry name" value="UREASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33569:SF1">
        <property type="entry name" value="UREASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00547">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001223">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54111">
        <property type="entry name" value="Urease, gamma-subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF84950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="100" mass="11242" checksum="A4010A48E3156A37" modified="2014-10-29" version="1">MMFAPREIDKLYIFMAAEVARKRRARGLKLNYPETVALISDHIVEGARDGRSVPELMRSGRQVLSRQDVLPGVPELVKQVQVEATFDDGTKLVTVHNPIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MV13</accession>
    <name>A0A075MV13_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Plastocyanin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NTE_03468</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987061.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MV13"/>
    <dbReference type="STRING" id="1459636.NTE_03468"/>
    <dbReference type="GeneID" id="41599101"/>
    <dbReference type="KEGG" id="nev:NTE_03468"/>
    <dbReference type="eggNOG" id="arCOG02926">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1709035_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000923">
        <property type="entry name" value="BlueCu_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028871">
        <property type="entry name" value="BlueCu_1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052721">
        <property type="entry name" value="ET_Amicyanin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36507">
        <property type="entry name" value="BLL1555 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36507:SF1">
        <property type="entry name" value="BLL1555 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00127">
        <property type="entry name" value="Copper-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00196">
        <property type="entry name" value="COPPER_BLUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="Blue (type 1) copper" evidence="6">
        <location>
            <begin position="68"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF85496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="160" mass="17717" checksum="4DCF670D4FE90794" modified="2014-10-29" version="1">MAFLKKNQKRMAAGISIMAFVVAVSASLAYYQFYYIPAINKKPQVSQDILNPPSITNVGILPGSSLESQAQNFFPSDVRVSLGANNKVIWKNNDNTYHSVTSDNDYVDKISGKFDSTATIGLMPSGQTYNFTFTEAGVYHYHCIPHPWMKGTVTVLAEHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MV76</accession>
    <name>A0A075MV76_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative cobalt transporter subunit (CbtA)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701111.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MV76"/>
    <dbReference type="STRING" id="1459636.NTE_02508"/>
    <dbReference type="GeneID" id="41598212"/>
    <dbReference type="KEGG" id="nev:NTE_02508"/>
    <dbReference type="eggNOG" id="arCOG06353">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090632_0_0_2"/>
    <dbReference type="OrthoDB" id="10422at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012666">
        <property type="entry name" value="CbtA_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09490">
        <property type="entry name" value="CbtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="243" mass="25541" checksum="9FBC5897EA92C4A2" modified="2014-10-29" version="1">MKTLTFIAISLLSGIIAGTILALVNQSVVLPFIERAIAIENQNAVAQGEMIDPTAMDAYRLWQKEGSVAAGALLGLSYGALLGVVFAYARKSLPGKNNIAKAVLLAGIMWIVIYLAVAVKYPANPPAVGNPDTIYLRMTLYVAMLAISGAAAIGSAFLYKKMGPQKSARKAVVPAVYVAVVIAAVFALPANPDPVTAPMDLVNGFRIASASTMAMFWLVLGAVLGVLWDKTKPHETATVKNAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MV85</accession>
    <name>A0A075MV85_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02518</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385482.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MV85"/>
    <dbReference type="STRING" id="1459636.NTE_02518"/>
    <dbReference type="GeneID" id="43502648"/>
    <dbReference type="KEGG" id="nev:NTE_02518"/>
    <dbReference type="HOGENOM" id="CLU_3075489_0_0_2"/>
    <dbReference type="OrthoDB" id="7170at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="52" mass="6010" checksum="046F41DADFF7838B" modified="2014-10-29" version="1">MSDKQAFALSADEWQVVLDALSNTIFNEELTEDARKKAKDLFVKLQKELPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MV88</accession>
    <name>A0A075MV88_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Homospermidine synthase (Spermidine-specific)</fullName>
            <ecNumber evidence="4">2.5.1.45</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_03043</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the deoxyhypusine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.45" evidence="4"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701542.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MV88"/>
    <dbReference type="STRING" id="1459636.NTE_03043"/>
    <dbReference type="GeneID" id="41598711"/>
    <dbReference type="KEGG" id="nev:NTE_03043"/>
    <dbReference type="eggNOG" id="arCOG04142">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039781_1_0_2"/>
    <dbReference type="OrthoDB" id="17730at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034038">
        <property type="term" value="F:deoxyhypusine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050514">
        <property type="term" value="F:homospermidine synthase (spermidine-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.910.10">
        <property type="entry name" value="Deoxyhypusine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002773">
        <property type="entry name" value="Deoxyhypusine_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036982">
        <property type="entry name" value="Deoxyhypusine_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001980">
        <property type="entry name" value="PRK00770.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703">
        <property type="entry name" value="DEOXYHYPUSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703:SF2">
        <property type="entry name" value="DEOXYHYPUSINE SYNTHASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01916">
        <property type="entry name" value="DS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF85078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="373" mass="41109" checksum="CA0AC27B4D49EF8C" modified="2014-10-29" version="1">MHDHNGHNHDNGDDSRHTFSGRKIDPPTVSPNMTVPDLIKFYGSTGYNARRLAEAAEILQDMIDTGSTVCLTLAGAMTPIGMGKTISKMIEAGFIDWIVATGANVYHDLHFAYGLPVKQGHFDVDDDVLYAKQIVRIYDVYIKEMETLQAQDLLVQKDIAERSDEIPKNASTADIAYALGKAAKENAKYSDKSFLVKAYEHNVPVYMPAIGDSSIGLNMLPLLLEGKGVFPNTILDVAESAAILWKSKRSGGLELGGGVPKNFFQQTGPALYQILKIKEGGQDYLIQMTDARPDTGGLSGATLQEGKSWGKIKTSHRGNVIVYGDSSVYFPLLCSYALSVCKPRKQKEIYAKKDKWVQEMKKIYFANSNKKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVB6</accession>
    <name>A0A075MVB6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IPT/TIG domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVB6"/>
    <dbReference type="KEGG" id="nev:NTE_03168"/>
    <dbReference type="HOGENOM" id="CLU_2021397_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IPT/TIG" evidence="1">
        <location>
            <begin position="40"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="122" mass="12569" checksum="5129436CBD355EB7" modified="2014-10-29" version="1">MLAAMVTVALLSTIAVRGLVAPSDNTAAATTQKQPAIKLQPNSDAPGSIVTVTGTDFSAKSPLSVSVDNKELPADTKVTTKDDGSFTATLKIPNDAKDGNHQIKVSDDKGKSATADFTVVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVS6</accession>
    <name>A0A075MVS6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Roadblock/LAMTOR2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03214</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701678.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVS6"/>
    <dbReference type="STRING" id="1459636.NTE_03214"/>
    <dbReference type="GeneID" id="41598871"/>
    <dbReference type="KEGG" id="nev:NTE_03214"/>
    <dbReference type="eggNOG" id="arCOG08684">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128582_0_1_2"/>
    <dbReference type="OrthoDB" id="1734at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046600">
        <property type="entry name" value="DUF6659"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20364">
        <property type="entry name" value="DUF6659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="121" mass="13506" checksum="F6FC75145B1D5BEF" modified="2014-10-29" version="1">MDFAKICDQVFALDDDIRYAGVIDDMGALVAGGMRKGIDSLTDQSNEELYLAQTALRKSMRHRFDNTLGRARFAYVERDRVSILTFYMDGHTLVVTLEPNLDSHTAMDIAKDTLDLLNGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVT0</accession>
    <name>A0A075MVT0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor Pcc1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CTAG/PCC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700188.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVT0"/>
    <dbReference type="STRING" id="1459636.NTE_01346"/>
    <dbReference type="GeneID" id="41597144"/>
    <dbReference type="KEGG" id="nev:NTE_01346"/>
    <dbReference type="eggNOG" id="arCOG04414">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2550391_0_0_2"/>
    <dbReference type="OrthoDB" id="8982at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015419">
        <property type="entry name" value="CTAG/Pcc1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011470">
        <property type="entry name" value="PRK14887.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09341">
        <property type="entry name" value="Pcc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="82" mass="8986" checksum="9E0254A1BF7DAEBB" modified="2014-10-29" version="1">MTSKACRAEIRIRVKEPSKARPIYSALAPDLKKLQGKNERLGLTVSGSSLGFSIETDDLASLRANVNSYLRLVDAAHRCLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVT2</accession>
    <name>A0A075MVT2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03224</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVT2"/>
    <dbReference type="STRING" id="1459636.NTE_03224"/>
    <dbReference type="KEGG" id="nev:NTE_03224"/>
    <dbReference type="HOGENOM" id="CLU_2447524_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="89" mass="10022" checksum="C1BFB14ABC56A0D6" modified="2014-10-29" version="1">MIFLSAGEQLMKLYLEAAENILLSSWLKSEMIHQEILLDGRQEKSFMLVGIFCSTYTAGVRLESGEGERIGISCMPVLSVVSYQILYIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVX0</accession>
    <name>A0A075MVX0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03254</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701714.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVX0"/>
    <dbReference type="STRING" id="1459636.NTE_03254"/>
    <dbReference type="GeneID" id="41598909"/>
    <dbReference type="KEGG" id="nev:NTE_03254"/>
    <dbReference type="HOGENOM" id="CLU_1607076_0_0_2"/>
    <dbReference type="OrthoDB" id="8891at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="165" mass="18879" checksum="FCC2B783D772F5FD" modified="2014-10-29" version="1">MGLSITPFLKDALADLYFRQTCDQEGWAYVSPKDASFIEKNTLVFAKGPRRIQVRVHEQIAQEIKQAMALFDYLACKVGQKEHSAIVVASPLALCWVKTRGGRSFTDDQLDQMSKIRLPLAVFRIRDVLVPPAKIETKWETKSGKEWLDEIDDKREEAESDDDYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MW10</accession>
    <name>A0A075MW10_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MW10"/>
    <dbReference type="STRING" id="1459636.NTE_03412"/>
    <dbReference type="KEGG" id="nev:NTE_03412"/>
    <dbReference type="HOGENOM" id="CLU_3002963_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="56" mass="6350" checksum="EE052ABC56849E87" modified="2014-10-29" version="1">MTSLSGQCKHKGETVRDKVTLKVFQANRIAGERSSETMSTNKQDEEYTKEEGERVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MW44</accession>
    <name>A0A075MW44_9ARCH</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701784.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MW44"/>
    <dbReference type="STRING" id="1459636.NTE_03339"/>
    <dbReference type="GeneID" id="41598988"/>
    <dbReference type="KEGG" id="nev:NTE_03339"/>
    <dbReference type="HOGENOM" id="CLU_1222564_0_0_2"/>
    <dbReference type="OrthoDB" id="12194at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="227" mass="24679" checksum="D949BBA5F1681D29" modified="2014-10-29" version="1">MSSDNDSSGNAEPKKESVFGIMDDLLSHLNRTKKFFMALVISSFVVAPLAIVLSILMLTPQFLTGVGQQQDVVFSQKASFSKAVPTTGMQAGQPAMITVKIVPGDEMKTFNITGLQQVDKGSFIVDKSQIHVDYVPANVAGFAVSPEGEVKPLPPRFMYVSSAPAASPFDVTWMIVAVIAVSATMAGAWLLIGIKEYRFFSHWNSRYANYKAMQEKVDKELDGSTGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MW68</accession>
    <name>A0A075MW68_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">YtkA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02844</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701380.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MW68"/>
    <dbReference type="STRING" id="1459636.NTE_02844"/>
    <dbReference type="GeneID" id="41598526"/>
    <dbReference type="KEGG" id="nev:NTE_02844"/>
    <dbReference type="eggNOG" id="arCOG08825">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1529152_0_0_2"/>
    <dbReference type="OrthoDB" id="11577at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="175" mass="18588" checksum="3E626A0244F81F56" modified="2014-10-29" version="1">MLLLKSLACAIALAAVFMLIVAKPAFADPLKNAMYKQRIGNYQFDVATEPAKLVSGVPAKVVMRISGVNGDDLVDVPVKIRLVKDGAEVATAGPIVIPYGHYAYDRTFAEPGKYVLYADLMDNAYSGQTLTFTFILNVAGPNDFYLYTVAPGIGAAGAAAAGAIVIIRSRRKSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWA0</accession>
    <name>A0A075MWA0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701827.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWA0"/>
    <dbReference type="STRING" id="1459636.NTE_03385"/>
    <dbReference type="GeneID" id="41599032"/>
    <dbReference type="KEGG" id="nev:NTE_03385"/>
    <dbReference type="eggNOG" id="arCOG08677">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1438065_0_0_2"/>
    <dbReference type="OrthoDB" id="6754at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="188" mass="21108" checksum="AA499557279BF6A2" modified="2014-10-29" version="1">MPPKNPKNAQGVVNVEFYKSVYEIAQKAAEAKGKSLKDFVNDIVLMSVEKDEFLKRYAPSLSFAGRTETSLFVKDDMKDRTAEIVIKDSQLICYLDESNDCEHVHFALALPELGTLNIKQKSVLPMTFTDSAGKTHLIDFRQGRPYCFKCKSYGCDYADIAETEHAIATNRPNKKANRGGESRVKDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWC4</accession>
    <name>A0A075MWC4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NTE_03522</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987068.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWC4"/>
    <dbReference type="GeneID" id="99755964"/>
    <dbReference type="KEGG" id="nev:NTE_03522"/>
    <dbReference type="eggNOG" id="arCOG07820">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_196680_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003844">
        <property type="entry name" value="UPF0060"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36116">
        <property type="entry name" value="UPF0060 MEMBRANE PROTEIN YNFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36116:SF1">
        <property type="entry name" value="UPF0060 MEMBRANE PROTEIN YNFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02694">
        <property type="entry name" value="UPF0060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF85550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="78" mass="8898" checksum="08E8789C7FDA687F" modified="2014-10-29" version="1">MQIPIRNRTLLTLFFFFLVGLCEIGGRYLVWLSIREKFALGIFGIVLFEYGMIPTLQQADFGCVYAAFGRICIVSLII</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWC7</accession>
    <name>A0A075MWC7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hemerythrin HHE cation binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701849.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWC7"/>
    <dbReference type="STRING" id="1459636.NTE_03410"/>
    <dbReference type="GeneID" id="41599054"/>
    <dbReference type="KEGG" id="nev:NTE_03410"/>
    <dbReference type="eggNOG" id="arCOG01471">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129160_0_0_2"/>
    <dbReference type="OrthoDB" id="372140at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.520">
        <property type="entry name" value="nmb1532 protein domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin-like" evidence="1">
        <location>
            <begin position="7"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="150" mass="16626" checksum="6C6396CBF720C754" modified="2014-10-29" version="1">MQFEIPESLKHEHEELHAELKKAIGAGGKVGEAAKAVAEALHLHFMKEEEYAMPPLGLLSALAEGRVTSDMKDVIPMTDKLKADLLHMLEEHKAIVASLKNLLDVANKEGKAEYAAFAEKLMLHAKNEEEVLYPASILVGEYLKERLKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWL1</accession>
    <name>A0A075MWL1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_03002</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701507.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWL1"/>
    <dbReference type="STRING" id="1459636.NTE_03002"/>
    <dbReference type="GeneID" id="41598672"/>
    <dbReference type="KEGG" id="nev:NTE_03002"/>
    <dbReference type="HOGENOM" id="CLU_2820607_0_0_2"/>
    <dbReference type="OrthoDB" id="379109at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF85037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="66" mass="7003" checksum="6C335CE3C7208A2A" modified="2014-10-29" version="1">MALLDSEGMQLVIEMAIASAAGMIGLWYLKKRTKDRSSSPLPPPSSSSSSAAQKNTDDDKKPPAPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWQ3</accession>
    <name>A0A075MWQ3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Universal stress protein UspA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_03515</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWQ3"/>
    <dbReference type="STRING" id="1459636.NTE_03515"/>
    <dbReference type="KEGG" id="nev:NTE_03515"/>
    <dbReference type="eggNOG" id="arCOG02053">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049301_16_2_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00293">
        <property type="entry name" value="USP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46268">
        <property type="entry name" value="STRESS RESPONSE PROTEIN NHAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46268:SF6">
        <property type="entry name" value="UNIVERSAL STRESS PROTEIN UP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UspA" evidence="2">
        <location>
            <begin position="11"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF85543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="108" mass="11750" checksum="3490FC0B1761D355" modified="2014-10-29" version="1">MKISYVKSSREYLKELYQGMKEAAVEMLADKKMALEETLEAAAGANAVKTLVRVGNPVEQILTVAKDNDVDLIIIGSGRLTGIRRITSLGSVARAVSERSMCPVMLVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWT5</accession>
    <name>A0A075MWT5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWT5"/>
    <dbReference type="STRING" id="1459636.NTE_03550"/>
    <dbReference type="KEGG" id="nev:NTE_03550"/>
    <dbReference type="HOGENOM" id="CLU_1840472_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="139" mass="15747" checksum="6F67998B38CE5896" modified="2014-10-29" version="1">MTKAFPCPPGITRYVCEKSFGETDKCNATFSCCLVDFCKSIYDSQNFVMDYQFRLKKNLASRQFEIVRTPCEIIETFANCRVIYKSPPDKGGVVFSGTFKEALDFANIELEKSCDYVRPYKPCTHCVPEIDAHCGSTSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWU1</accession>
    <name>A0A075MWU1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03083</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWU1"/>
    <dbReference type="STRING" id="1459636.NTE_03083"/>
    <dbReference type="KEGG" id="nev:NTE_03083"/>
    <dbReference type="HOGENOM" id="CLU_3112879_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="50" mass="5818" checksum="5F27DEBAAA49FE57" modified="2014-10-29" version="1">MARMAKMERTARTETSSLYSIKTFFIIIYEHLHIPFAILKLQSKALSDQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MX03</accession>
    <name>A0A075MX03_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03145</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MX03"/>
    <dbReference type="KEGG" id="nev:NTE_03145"/>
    <dbReference type="HOGENOM" id="CLU_2985487_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="57" mass="6467" checksum="A20B1109F2892F73" modified="2014-10-29" version="1">MVDKSDIERIIREVERENVLFNNDKGCLDALTKIDLRIRSPILLCPLDAQLFGGLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MXU2</accession>
    <name>A0A075MXU2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F5/8 type C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701845.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MXU2"/>
    <dbReference type="STRING" id="1459636.NTE_03404"/>
    <dbReference type="GeneID" id="41599050"/>
    <dbReference type="KEGG" id="nev:NTE_03404"/>
    <dbReference type="HOGENOM" id="CLU_851530_0_0_2"/>
    <dbReference type="OrthoDB" id="385929at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F5/8 type C" evidence="1">
        <location>
            <begin position="170"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="326" mass="35277" checksum="4E669F8D3056457E" modified="2014-10-29" version="1">MWGGLSEQQIADIVEKQVGVNKVKMPSPVVGDYQSPVLAVATSDTIATTPVTWSATSTSSHSLRSGSYTRAGMRITDATKRGLYLLSATFYMGKALNPTGNVVATLRKTSDDSIIASSTPIDATTINSNENPVTFTFNRALTPNEDFRISVEYSGGDASNFLSVFGNFGSSQYSGGMWSLYAGSWGDDGIGRDLRGSMTLSAEAYVLDGNTATAWNSNSQTNPFIYLDMGSSKLISGVRIYWPTSNRPTNYVIETSIDTLTWTPVLTLNSQPAANAWTEYAFNTVVARYFRVRDLDAGSVVMSIAEIQYYVKTTDQVLSTHGHGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MY00</accession>
    <name>A0A075MY00_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02104</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MY00"/>
    <dbReference type="STRING" id="1459636.NTE_02104"/>
    <dbReference type="KEGG" id="nev:NTE_02104"/>
    <dbReference type="eggNOG" id="ENOG502N57Z">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_986701_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="256" mass="29344" checksum="AE0710AFD3A06377" modified="2014-10-29" version="1">MLELLSLHIRQEADRYRAGLQTRSIIHDVEELAVKKGYAFQRQDKDKVLYLISEFMTEGLIGWGLNYDNPEPPFMHISEYGRAVVLSQKPQPYDPDGYLANLKTEIPGIDETIMIYITEALQTLRRNNLFSAAVMTGVASERAFELLLDAVSNAVTGNGQPEKFEKLKNDTRTKYKFDEVKKVVMQLPVQRRNEIDENLESNLDGVFNLIRITRNDAGHPTGKKVRREDVLVNLSVFVPYCKCIYRLIGHLEKNPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MZA2</accession>
    <name>A0A075MZA2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02532</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701125.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MZA2"/>
    <dbReference type="STRING" id="1459636.NTE_02532"/>
    <dbReference type="GeneID" id="41598231"/>
    <dbReference type="KEGG" id="nev:NTE_02532"/>
    <dbReference type="HOGENOM" id="CLU_1514544_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="183" mass="20376" checksum="BB8653FFEA03335F" modified="2014-10-29" version="1">MSTNKSINQSIHAVQTDNFGRKYQFVQNDISNLALEGREERVVIDQKESGELYLFELHGNYRYLGLNVEIWGTSGAGVSIQQGHETFVDLITKNWGVGAGEVAPVAGISPDPAGKSNPRHPYILRYKSTEEADITGQEGQKYSLAFTPIPYTPYASRIRVTLVNRGSEVGIIEDFAITRKVWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MZJ6</accession>
    <name>A0A075MZJ6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Flavin-dependent oxidoreductase, F420-dependent methylene-tetrahydromethanopterin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NTE_02626</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MZJ6"/>
    <dbReference type="STRING" id="1459636.NTE_02626"/>
    <dbReference type="KEGG" id="nev:NTE_02626"/>
    <dbReference type="eggNOG" id="arCOG02410">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027853_7_1_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008726">
        <property type="term" value="F:alkanesulfonate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046306">
        <property type="term" value="P:alkanesulfonate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="entry name" value="Luciferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019921">
        <property type="entry name" value="Lucif-like_OxRdtase_Rv2161c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050172">
        <property type="entry name" value="SsuD_RutA_monooxygenase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03619">
        <property type="entry name" value="F420_Rv2161c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42847">
        <property type="entry name" value="ALKANESULFONATE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42847:SF4">
        <property type="entry name" value="ALKANESULFONATE MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="Bacterial luciferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Luciferase-like" evidence="5">
        <location>
            <begin position="34"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF84669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="331" mass="36741" checksum="E8DD1050D67145C4" modified="2014-10-29" version="1">MKKNVFKILIRADAAFAHTHMKAGILLPQVTEHATKENLLYIAKEAEKEGLDSAWVFERLLWPLKPQTPYVATPDGSLPTEYQNVLDPLETLTYIAGNTTKISLGTCLIDMLFHNPVVLARRFATLDVLSGGRVIAGLGIGWSKDEYEVSGVPYKQRGARADEFLQALKRIWTDDVVEFKGQFYNIPASKIGPKPVQKPHPPVLLGGFSPKVFSRIVNYADGWLPIAGVGPLEQLEQAVSGLREGARKAGKDPSKVRVFVLSYPTVMDSPSPNQQQRWPMTGTIDQIGSDIERIKAIDGVDHIIFGYAFSSVGRDVKKMIEITKQLVRFAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MZM9</accession>
    <name>A0A075MZM9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ferredoxin subunit of nitrite reductase and ring-hydroxylating dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NTE_02651</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701220.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MZM9"/>
    <dbReference type="STRING" id="1459636.NTE_02651"/>
    <dbReference type="GeneID" id="41598343"/>
    <dbReference type="KEGG" id="nev:NTE_02651"/>
    <dbReference type="eggNOG" id="arCOG02852">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055690_5_2_2"/>
    <dbReference type="OrthoDB" id="6837at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03528">
        <property type="entry name" value="Rieske_RO_ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21496:SF23">
        <property type="entry name" value="3-PHENYLPROPIONATE_CINNAMIC ACID DIOXYGENASE FERREDOXIN SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21496">
        <property type="entry name" value="FERREDOXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="5">
        <location>
            <begin position="6"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF84694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="106" mass="11532" checksum="FEF0B27DA6E1E9EA" modified="2014-10-29" version="1">MGEEWVRVCDAGSLSSGELVEFDHGGKKLMVAKIGSDIYATDRICTHAYADLTAGFVNEGEKTVTCPLHLSAFKFADGVPQNPPATIPLKTYKVKIQDNAIYIKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N020</accession>
    <name>A0A075N020_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATP:cob(I)alamin adenosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NTE_02804</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Cob(I)alamin adenosyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701351.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N020"/>
    <dbReference type="STRING" id="1459636.NTE_02804"/>
    <dbReference type="GeneID" id="41598492"/>
    <dbReference type="KEGG" id="nev:NTE_02804"/>
    <dbReference type="eggNOG" id="arCOG00489">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083486_0_2_2"/>
    <dbReference type="OrthoDB" id="4665at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008817">
        <property type="term" value="F:corrinoid adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009235">
        <property type="term" value="P:cobalamin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1200.10:FF:000001">
        <property type="entry name" value="Cob(I)yrinic acid a,c-diamide adenosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1200.10">
        <property type="entry name" value="Cobalamin adenosyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016030">
        <property type="entry name" value="CblAdoTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036451">
        <property type="entry name" value="CblAdoTrfase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029499">
        <property type="entry name" value="PduO-typ"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00636">
        <property type="entry name" value="PduO_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12213">
        <property type="entry name" value="CORRINOID ADENOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12213:SF0">
        <property type="entry name" value="CORRINOID ADENOSYLTRANSFERASE MMAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01923">
        <property type="entry name" value="Cob_adeno_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89028">
        <property type="entry name" value="Cobalamin adenosyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cobalamin adenosyltransferase-like" evidence="6">
        <location>
            <begin position="3"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF84844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="191" mass="20760" checksum="3A96A40209103890" modified="2014-10-29" version="1">MKIYTKTGDKGETGLIGGRRVSKADLRIVAYGAVDELNSSIGLAVSSLCGKEKVFSDLADVLTQVQNDLFIVGSDLADSDYPKSQYNTPRTDENMASALEPVIDKFESELEPITFFILPGGSAEASMLHVCRGVARRAETAAVALYRSESINPAIIMYLNRLADLLFVAARLANKRQGVPDVAWKKKKSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N066</accession>
    <name>A0A075N066_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Elongation factor 1-alpha</fullName>
            <shortName evidence="9">EF-1-alpha</shortName>
            <ecNumber evidence="9">3.6.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Elongation factor Tu</fullName>
            <shortName evidence="9">EF-Tu</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">tuf</name>
        <name evidence="11" type="ORF">NTE_02856</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">GTP hydrolase that promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.3" evidence="9"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701390.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N066"/>
    <dbReference type="STRING" id="1459636.NTE_02856"/>
    <dbReference type="GeneID" id="41598538"/>
    <dbReference type="KEGG" id="nev:NTE_02856"/>
    <dbReference type="eggNOG" id="arCOG01561">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007265_3_5_2"/>
    <dbReference type="OrthoDB" id="371718at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03693">
        <property type="entry name" value="EF1_alpha_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03705">
        <property type="entry name" value="EF1_alpha_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000005">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000255">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000020">
        <property type="entry name" value="Translation elongation factor EF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_A">
        <property type="entry name" value="EF_Tu_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004539">
        <property type="entry name" value="Transl_elong_EF1A_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00483">
        <property type="entry name" value="EF-1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008969">
        <property type="entry name" value="PRK12317.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9 11" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="6"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="15"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="93"/>
            <end position="97"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="155"/>
            <end position="158"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIF84894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="437" mass="47358" checksum="233BAE737F532EE7" modified="2014-10-29" version="1">MSASKKPHLNIVVTGHVDNGKSTTVGHLLVDLGAIDQRTIDAYAKESEATGKGDTFKYAWVMDSIKDERERGITIDLAFQKFETGKYFFTLIDAPGHKDFIKNMITGASEADAAILVISVKPGETEASIEPGGQGREHAFLAKTLGVGQIVVALNKMDDVGYQEARYKEVRDNVEKMLKSVGFNIAKVNFVPVSGWKGDNLVKKSENMPWYKGPTLAEALDAFEPPEKPIGKPLRVPIQDVYTITGVGTVPVGRVETGKMRPNDKVVVMPSGAVGEIKSIETHHTVLESAEAGDNVGFNLRGVDKKQIKRGDIIGPSDNPPAVAKEFEARIIVISHPTAIAPGYTPVLHAHTAQVAATISHFVSKIDPRTGATTEENPKFLKTGDAAIVKIKPVRPLAIETFKDFPEIGRFALRDMGTTIAAGVVLNITEKYDPNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N0U1</accession>
    <name>A0A075N0U1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rhodanese-related sulfurtransferase</fullName>
            <ecNumber evidence="3">2.8.1.1</ecNumber>
            <ecNumber evidence="3">2.8.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_03054</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.8.1.1" evidence="3"/>
    <dbReference type="EC" id="2.8.1.2" evidence="3"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N0U1"/>
    <dbReference type="STRING" id="1459636.NTE_03054"/>
    <dbReference type="KEGG" id="nev:NTE_03054"/>
    <dbReference type="eggNOG" id="arCOG02019">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031618_1_6_2"/>
    <dbReference type="OrthoDB" id="9977at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016784">
        <property type="term" value="F:3-mercaptopyruvate sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01448">
        <property type="entry name" value="TST_Repeat_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051126">
        <property type="entry name" value="Thiosulfate_sulfurtransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43855">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43855:SF1">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="59"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="189"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF85089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="305" mass="34138" checksum="E132A3540AD2FBA8" modified="2014-10-29" version="1">MRGLRKKVVAAKAKVKAKPKPKAVVKKAKPAAVATTTKKQEFVQLPIVCDADTLRTLVRKKSVRVVDVRKADDYAAGHIPTAVSLPLARLLEDDKPERVVQLLEEFGITEKMPVVIYDDTFGALAARVAWTFQYVGHTNTALLEMTFGQWKELGLETETKPNKYPPSKHPLAINRDIYADAQYVEAAQSQQGKLLVDSRERLNFLTEHIPTARNIPYTMLGANGNILRKADELKRMIENRGIAPDSEIITYCGSVGTLSGLAYYALKLAGYNNVKLYPKSFKEWKSLGKPKDEFKEANYWDLSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MKY7</accession>
    <name>A0A075MKY7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MKY7"/>
    <dbReference type="STRING" id="1459636.NTE_00022"/>
    <dbReference type="KEGG" id="nev:NTE_00022"/>
    <dbReference type="eggNOG" id="arCOG04362">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062767_3_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038723">
        <property type="entry name" value="ArnR1-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14947">
        <property type="entry name" value="HTH_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ArnR1-like winged helix-turn-helix" evidence="1">
        <location>
            <begin position="54"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="286" mass="31935" checksum="D9CA084F9AA0B150" modified="2014-10-29" version="1">MLKIRTTIADSLKTASVTVKASYTLVAPGGEEKLAAQDVSELLFSLASADRLTLLSEVNTRKQRLTTLAKTINASTQECSRHLARLSDAGFIKKDPDGLYETTALGKTILTLFPTIEFLLKHKDNYFLSHDLSFLPRSFIERIGELSEGEYVNHVSQVLKHIKTVISEAREYVWLISDQPIVTGMSVGKSFQSRTLTVRLIAEQITDRKEFVDAKSILPEKFEVAMLQDVQIALAINETTAGVCFPGLDGEIDFGKGFSGKDPQFRAWCCDLFEHYWAGSRKIAFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLF5</accession>
    <name>A0A075MLF5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00184</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699292.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLF5"/>
    <dbReference type="GeneID" id="41596114"/>
    <dbReference type="KEGG" id="nev:NTE_00184"/>
    <dbReference type="HOGENOM" id="CLU_2550071_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="82" mass="9143" checksum="60762A9C5684B1C1" modified="2014-10-29" version="1">MSAEGHQNNDNKKPARKPNLGKNEVNEYPRQGNLDPELGLVGEKGVQEVAEKEGERVGKDIKKRIRKGQDEGVTFDPSRSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLN5</accession>
    <name>A0A075MLN5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00314</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLN5"/>
    <dbReference type="KEGG" id="nev:NTE_00314"/>
    <dbReference type="HOGENOM" id="CLU_196475_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="80" mass="8693" checksum="2C467DCFFFC3A2A0" modified="2014-10-29" version="1">MRIVLVATTVINNCLVCGLKIAESSSGITVGGDKWYHLKCVTVIKCDNCGTLIGYLANGKTEGRFRKTYCAKCSKKFGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLZ5</accession>
    <name>A0A075MLZ5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA(Ile2) 2-agmatinylcytidine synthetase TiaS</fullName>
            <shortName evidence="6">tRNA(Ile2)-agm2C synthetase</shortName>
            <ecNumber evidence="6">6.3.4.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">tRNA(Ile2) agmatidine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tiaS</name>
        <name evidence="10" type="ORF">NTE_00071</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>cytidine(34) in tRNA(Ile2) + agmatine + ATP + H2O = 2-agmatinylcytidine(34) in tRNA(Ile2) + AMP + 2 phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:43608"/>
            <dbReference type="Rhea" id="RHEA-COMP:10625"/>
            <dbReference type="Rhea" id="RHEA-COMP:10626"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58145"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:83545"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TiaS family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.22" evidence="6"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699212.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLZ5"/>
    <dbReference type="STRING" id="1459636.NTE_00071"/>
    <dbReference type="GeneID" id="41596021"/>
    <dbReference type="KEGG" id="nev:NTE_00071"/>
    <dbReference type="eggNOG" id="arCOG01115">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_675459_0_0_2"/>
    <dbReference type="OrthoDB" id="39189at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002101">
        <property type="term" value="P:tRNA wobble cytosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04482">
        <property type="entry name" value="RPA2_OBF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1010">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.600.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01892">
        <property type="entry name" value="tRNA_Ile2_agm2C_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053870">
        <property type="entry name" value="TiaS-like_TCKD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013696">
        <property type="entry name" value="TiaS_FLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024913">
        <property type="entry name" value="tRNA_Ile2__agm2C_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055394">
        <property type="entry name" value="Zn_ribbon_TiaS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40705:SF2">
        <property type="entry name" value="DUF1743 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40705">
        <property type="entry name" value="TRNA(ILE2) 2-AGMATINYLCYTIDINE SYNTHETASE TIAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08489">
        <property type="entry name" value="TiaS_FLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22641">
        <property type="entry name" value="TiaS_TCKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23783">
        <property type="entry name" value="Zn_ribbon_TiaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TiaS-like TCKD" evidence="8">
        <location>
            <begin position="6"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="TiaS FLD" evidence="7">
        <location>
            <begin position="142"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="TiaS C-terminal zinc ribbon" evidence="9">
        <location>
            <begin position="359"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIF82155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="438" mass="48253" checksum="918587681BA2FA43" modified="2014-10-29" version="1">MTLLHIAFDDTDSRAGRCTTHLAFRVAGELQKTMGAELVDYPLLIRLNPNIPWKTRGNGAVCLRARLKDAGRAVDYVRQAVEEGSAIGSGANPGMAFLEGEEILPEKLKQFSAFAMCDVSSRQQAEKVAKECGIKFWTFGNGQGLVGALGAMGCALDGDHTFELIAYRTPENCGTPRVVDNDRIIKFSKETFPYTFNNYDQNHGRVLIAPHGPDPVFFGVRGESPEVVSSAMSKILPAEKLEGHMVFRSNQGTNMHLQNELDLRAAKAYTAGHVRCRVKSKPYAMEGGHVMFSVEQSGAEMPAAVYEPTGLANVAVALAPGDLVEIGVGVRKGTTLHPKILNVEYLLVKELAPVYDVANPLCKMCGRRMKSEGRNKGYQCEKCKFRDQKAQKIMVEKVRAIKPGLYVPTPKAHRHLTKPVHRYGMEKTGFQYTTSYVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MM47</accession>
    <name>A0A075MM47_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00246</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MM47"/>
    <dbReference type="KEGG" id="nev:NTE_00246"/>
    <dbReference type="HOGENOM" id="CLU_2678681_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="74" mass="7863" checksum="10FC6F8877B57F10" modified="2014-10-29" version="1">MEKYLKSFVPRYTPMSNLKAIIAVVAIVAAMGLVAAAVVPSVVLPQQAFADPPHGNSFKHCHSFGPGHSDDACR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MME6</accession>
    <name>A0A075MME6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MME6"/>
    <dbReference type="KEGG" id="nev:NTE_00565"/>
    <dbReference type="HOGENOM" id="CLU_2519584_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="84" mass="9260" checksum="09A2FA817D90E00A" modified="2014-10-29" version="1">MAKMGGMAETAWTEPSALFLACTHRATVHSQASERLQTPDKEKVVEREGGQMPKWLYQFILMISIVEIDTCISAASALGSKARF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMG0</accession>
    <name>A0A075MMG0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00238</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMG0"/>
    <dbReference type="KEGG" id="nev:NTE_00238"/>
    <dbReference type="HOGENOM" id="CLU_200166_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="60" mass="7067" checksum="5799FEC04751975D" modified="2014-10-29" version="1">MQKPIEIRPLKPKRNMIRQYCEECEEEATKEAVFDLENFVAVRRFCGRCVETAKVDFAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMP4</accession>
    <name>A0A075MMP4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00028</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699180.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMP4"/>
    <dbReference type="STRING" id="1459636.NTE_00028"/>
    <dbReference type="GeneID" id="41595980"/>
    <dbReference type="KEGG" id="nev:NTE_00028"/>
    <dbReference type="HOGENOM" id="CLU_1202581_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="230" mass="24632" checksum="5EE94B9C349D62DF" modified="2014-10-29" version="1">MSAAASSGDKSSSPSLTIPVVAGLAVGIVLIFLLSVAVEQAPQVSAEMTAAGKVVCLPHKKSLLGEGVPETDECRGGFLRIDNGKYYALHVEDDDQKYYWIFSTNQSNELINVTGTIRPALGTDHYERYDIAGVIDNISSVGAADGHISIYEVAYAYDKQLSSILDKIHAKTGGGYSMGVDKECSGSSNNGSGSSNPCIRITLEKDDPELRKQIPNQLEGFMVDVQILNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMT8</accession>
    <name>A0A075MMT8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Luciferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00666</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699655.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMT8"/>
    <dbReference type="GeneID" id="41596526"/>
    <dbReference type="KEGG" id="nev:NTE_00666"/>
    <dbReference type="eggNOG" id="arCOG11894">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_159352_0_0_2"/>
    <dbReference type="OrthoDB" id="7649at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040841">
        <property type="entry name" value="Luciferase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17648">
        <property type="entry name" value="Luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Luciferase" evidence="1">
        <location>
            <begin position="35"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="112" mass="13027" checksum="957D7A715831BFC2" modified="2014-10-29" version="1">MMANALERVKSELLSWPGVETKTHRFGGTEFDLNGREMGHMHGSSWADLPFPMDVRKELVEKGKVSPHHILPESGWVTFYVKSDEDVQELIKLFRMQYERLNSNNKKLQQPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMT9</accession>
    <name>A0A075MMT9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Archaeal flagellin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00388</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_420835299.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMT9"/>
    <dbReference type="GeneID" id="99755925"/>
    <dbReference type="KEGG" id="nev:NTE_00388"/>
    <dbReference type="HOGENOM" id="CLU_2747964_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013373">
        <property type="entry name" value="Flagellin/pilin_N_arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02537">
        <property type="entry name" value="arch_flag_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0282">Flagellum</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="70" mass="7601" checksum="736D996F964FA257" modified="2014-10-29" version="1">MVIEFHSISDAMSNKTFDARNNNRRAKKGISPVIATVILVAVAVVIAAALAGFSSSLYCHFTLWRSYGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMU2</accession>
    <name>A0A075MMU2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conserved domain protein, TIGR02271+C111</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_00671</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699659.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMU2"/>
    <dbReference type="GeneID" id="41596530"/>
    <dbReference type="KEGG" id="nev:NTE_00671"/>
    <dbReference type="HOGENOM" id="CLU_1259130_0_0_2"/>
    <dbReference type="OrthoDB" id="11897at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019060">
        <property type="entry name" value="DUF2382"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052967">
        <property type="entry name" value="Stress_Response_Assoc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02271">
        <property type="entry name" value="YsnF/AvaK domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38463">
        <property type="entry name" value="STRESS RESPONSE PROTEIN YSNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38463:SF1">
        <property type="entry name" value="STRESS RESPONSE PROTEIN YSNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09557">
        <property type="entry name" value="DUF2382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2382" evidence="2">
        <location>
            <begin position="103"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF82751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="234" mass="26811" checksum="77CFA215EE94B31B" modified="2014-10-29" version="1">MEHRISSIDWSDVIKKEARGTDDSDFGEVQEVGQNYVLTQRGTLEKERFYIPKYLVNGYDGHTLWFDAGNVDMTEFKRDSPPQYEEYGRYKREGMPADIETRIPLIEERLDVTKRLKTGEVTIAKEPVTETKTLEVPVTHEEVRVERRPTTGAETAMAETTDRPVESRTEVNVPVTSEEVEVTKRPYVKEEVVVTKEPVTETETVSDTVRSEKVDTKNVRGRGEFKKTTTSETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMW3</accession>
    <name>A0A075MMW3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00088</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158384861.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMW3"/>
    <dbReference type="GeneID" id="43502535"/>
    <dbReference type="KEGG" id="nev:NTE_00088"/>
    <dbReference type="HOGENOM" id="CLU_3178709_0_0_2"/>
    <dbReference type="OrthoDB" id="373009at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="46" mass="5563" checksum="A9BFEAF4285ECBC7" modified="2014-10-29" version="1">MKKFCGRCKKEIPPYSQYLLCGDCHKKVALAEDDREFFENSRVHWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMY1</accession>
    <name>A0A075MMY1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative nucleic-acid-binding protein containing a Zn-ribbon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699233.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMY1"/>
    <dbReference type="STRING" id="1459636.NTE_00105"/>
    <dbReference type="GeneID" id="41596048"/>
    <dbReference type="KEGG" id="nev:NTE_00105"/>
    <dbReference type="eggNOG" id="arCOG01285">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_165225_0_0_2"/>
    <dbReference type="OrthoDB" id="9573at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.30.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002878">
        <property type="entry name" value="ChsH2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052513">
        <property type="entry name" value="Thioester_dehydratase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34075">
        <property type="entry name" value="BLR3430 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34075:SF5">
        <property type="entry name" value="BLR3430 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01796">
        <property type="entry name" value="OB_ChsH2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ChsH2 C-terminal OB-fold" evidence="1">
        <location>
            <begin position="49"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="125" mass="13635" checksum="77848E8538BA3CBE" modified="2014-10-29" version="1">MDTHGVREKFIEVASRKKILAHRCVKCGHTMLETVMFCEKCSASKFEDVELEGAGTVVTYTIQAVAPAGFEDAGSYAWVVFKINNANIRASGFLPGIKEPKDLPVGAKVRVAGFDQHHGLLLEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMZ9</accession>
    <name>A0A075MMZ9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative solute binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NTE_00773</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial solute-binding protein 5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699742.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMZ9"/>
    <dbReference type="STRING" id="1459636.NTE_00773"/>
    <dbReference type="GeneID" id="41596624"/>
    <dbReference type="KEGG" id="nev:NTE_00773"/>
    <dbReference type="eggNOG" id="arCOG01672">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG10597">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010991_0_0_2"/>
    <dbReference type="OrthoDB" id="194307at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904680">
        <property type="term" value="F:peptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.105.10">
        <property type="entry name" value="Dipeptide-binding Protein, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049886">
        <property type="entry name" value="CFI_box_CTERM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041770">
        <property type="entry name" value="CFI_box_CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290:SF9">
        <property type="entry name" value="OLIGOPEPTIDE-BINDING PROTEIN APPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PERIPLASMIC BINDING COMPONENT OF ABC TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="937"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="976"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1000"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="domain" description="Solute-binding protein family 5" evidence="6">
        <location>
            <begin position="38"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="811"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="826"/>
            <end position="843"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF82851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="1039" mass="112525" checksum="69FBD7E673606246" modified="2014-10-29" version="1">MNRGGAPLLSVSIILVLLLSAFSTTVFNTAYAQQQQQEKKGPYVNQVTFIHRDDENLALEDIKSGNLDAYYFQIPLEAAADAKNDPRVTVYDRTAGSAGLLMNPAPSKDGNSLNPFSLKEVRFAMNYLIDRQFVVNEIYKGYGSPLIDPFGIYSPEYLNVIDTVESFGFSYNPGLAEKMISDAMTAAGATKDAASGNKWMFKGSPVAVKIMIRLDDTQRKSIGELVASKLEEAGFTVQKDFGDLTKANTIVYASNPQDFKWHLYTEGLAGTSVFVKYNPIIPGQMYAPWVGNMPGSQNPSFWNYKNSTLDDVTQKIFFANFTSAEERSKLVNTAVKGGIQESVRIFLAQRTEPFVASASLKGMVNDFGAGITSKYSLLNVRPPDGKGALNIGVKQIHQGSWNNIAGLSDAYSRDIFYSVYDSATFRDPYTGDIIPMRTQWTDISTQGPTGKLKVSENAQTWDPATQKWKDAGPNATATSKVTYKLLYSKWHNGIPMDKSDLLFSEYFTFEWGTDSGNGDRTVDPEYTSGVAPGLPRLKGIEFTSNDTLESYVNYWHYDDKEIADFAPVWPAEPWEITAATERLVTDGKFAYSRSQAVAKNIDWLDPIVPEHAQAIKQELQQMKSENYIPAALKGIVSADEAKKRYDASIAWINTHKNAVISNGAFYLDNFNIAGGTITIKAFRDPSYPFEQGHWSAYENPKLATIEKVNAAQMIEIGKPAEMTVSLQVDGKPSNDALVEYFIFNKDGKVALRGEAKPAQDSAGTFKVELTQDDTSKLTQGPNQLKIFANSKYAFRPDISTNTILAVASAAAPSSSNNGTGGGGGQTTTTLSGGNGGQQQQPAQPSGCLIATAAFGSELTPQVQYLRNFREHYILSTASGSAFMNAFNSIYYSFSPQVADYERQQPWLQATVKAALYPLFGILMASEKAYSSAAGGDAGAVAAGAVASTLIGAVYLWPATLSARLQSRFGTAAKISLAVMCGAVALIAIGMATTAGGNAPLLLLSIGTSLFVLSAASASAIAVGKLARIGYSALARTGRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MN01</accession>
    <name>A0A075MN01_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">D-glucuronyl C5-epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_00778</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699745.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MN01"/>
    <dbReference type="STRING" id="1459636.NTE_00778"/>
    <dbReference type="GeneID" id="41596629"/>
    <dbReference type="KEGG" id="nev:NTE_00778"/>
    <dbReference type="eggNOG" id="arCOG07790">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057836_0_0_2"/>
    <dbReference type="OrthoDB" id="95923at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047464">
        <property type="term" value="F:heparosan-N-sulfate-glucuronate 5-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015012">
        <property type="term" value="P:heparan sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010598">
        <property type="entry name" value="C5-epim_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039721">
        <property type="entry name" value="C5-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13174">
        <property type="entry name" value="D-GLUCURONYL C5-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13174:SF3">
        <property type="entry name" value="D-GLUCURONYL C5-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06662">
        <property type="entry name" value="C5-epim_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-glucuronyl C5-epimerase C-terminal" evidence="2">
        <location>
            <begin position="85"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF82856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="273" mass="30947" checksum="22FDB345DA0E25F8" modified="2014-10-29" version="1">MATSERRTGGNNSRGPVPDENGVMMYDYGGSTGIVYNPTVVATYGLQYHDSYQRTGDPQARQNLINTADWLLEHAKEQKYKCSKYSLWQYGFRWGWYGGVDPPYASALAQAEGINVLLLANEMTGGGGHDRYVAEAKRAFGAFLVDYDDGGVTSDEGRDSIFLQLLAKPGFQKTYVLNGHLNSLIQVWKYYQYTRDYRALIVFGKGVNWLTADGNLQKYYTGDWSYYDQMGNRAQDNYHRGHISQLGKLYEITGEPVLKEYCDRFAACIRQDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MN08</accession>
    <name>A0A075MN08_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Purine-cytosine permease-like transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NTE_00793</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699755.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MN08"/>
    <dbReference type="STRING" id="1459636.NTE_00793"/>
    <dbReference type="GeneID" id="41596643"/>
    <dbReference type="KEGG" id="nev:NTE_00793"/>
    <dbReference type="eggNOG" id="arCOG03447">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035711_2_0_2"/>
    <dbReference type="OrthoDB" id="9945at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015209">
        <property type="term" value="F:cytosine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030191">
        <property type="entry name" value="CodB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30569:SF0">
        <property type="entry name" value="CYTOSINE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30569">
        <property type="entry name" value="CYTOSINE TRANSPORTER CODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="330"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="353"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="396"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="457"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="471"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF82871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="514" mass="53661" checksum="1573E2CE409C37CB" modified="2014-10-29" version="1">MVEQEEYAERPVPEHARLGFMKPTLVWAGFTYAYICIFIGSQIMGGLGAPMGYVAIIAGQVFLFGYAGLIAHKSSKLGLNFPMMCKAAFGRYAYALPVLMIAGLVTGWYAFQAWLAADLMVGLYGGQSFNAGTGSGVLPGILGTTGFWAGVFAIVFGMFAVYGVRAMAWMGWFAVISVTALAGWMIYSIVSVVGVETGGNLFSSQPIGEPWTFAMGFTASVGTFIVSATMTGDFNRWTKSVKQSWGVIAVAFLAANMLMLMTGGIFTAVAGKLDFFFGLGTLALGIPIMIIQWASNGSTCDGCMYNATQGFKNVVYYISGKRLNFSWKKMAIIVMIAGTAVAAANLLTSIVPWLLLLGSVVPLVGGILIGHFWIVARKCTPDELLAAGDKKINGPAVTGFLAGLAIAIGIQLVAPDLPAVLGGLIGGVGVYPLVAKITGYTKGGRLTPKGLGTSASYGAAGTADQPPTPSAPGSGVAASGGQASPCGRIDRLVEFMTPFWSSLSYRGGGGSQFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MN25</accession>
    <name>A0A075MN25_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">NTE_00468</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699500.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MN25"/>
    <dbReference type="STRING" id="1459636.NTE_00468"/>
    <dbReference type="GeneID" id="41596343"/>
    <dbReference type="KEGG" id="nev:NTE_00468"/>
    <dbReference type="eggNOG" id="arCOG02358">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG03644">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031353_0_0_2"/>
    <dbReference type="OrthoDB" id="8127at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00075">
        <property type="entry name" value="HATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
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    </dbReference>
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        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="dCache_1"/>
    </dbReference>
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        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
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        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
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        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050736">
        <property type="entry name" value="Sensor_HK_Regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43711:SF1">
        <property type="entry name" value="HISTIDINE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43711">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02743">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
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    </dbReference>
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        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
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    </dbReference>
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        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="13">
        <location>
            <begin position="407"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
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            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="640" mass="69749" checksum="9CDF8408BB26675A" modified="2014-10-29" version="1">MMNITAIKWNQPLLLVSSIALIAILLAFSSYQFFNDASNKITEIAAGENRASARILAHDLANSLANKLGGIQQNVQMIAQASSVQEKSIEKVSTLLEITQQTSGDMTDFYGWLDKDGRIDRTSSITDNENSAQFFFGADKSDRDWFINARDAKKGYASSAEKSPDDDGIDRLFISYPIIDSQSGSFEGVIYAGIPLAKVNNYLGSQIYPGEKEIAMDILDMKGTILQTTKHPSLLGMNYFSKEYQDAIAGVEEKAADDTSNSSGGLQEFTRYALANSSSSPPSSSSSGSDDGVSDFTYGDGQTVSIAYSYVKLDNTNFAVVFTRVSHGSAADVEAFIDQQRFTSMARIAVIGTAAVFIGALVLLWNRKLERTVADRTQALASKTAELLAANEQLKQHDRLQKEFINIAAHELRTPITPILTSIDTVRSIRDPNGENMVILSEGYYDIILRNIKRLERLSSDILQAARIESGNFSLHKEKFDLGRLINNVVVDASESMPDSKRGSIQVVFEPNHNDGNLVVEADQSKLYEVMTNLMQNAVRFTVEGKITVSTEKKSFEGLGRGAAVVVKVKDTGSGIAQDILPRLFQKFASASSRDNLGGTGLGLYVSKAIVEAHGGKIWAQNNADGKGATFSFSIPIQTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNE8</accession>
    <name>A0A075MNE8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
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    <dbReference type="STRING" id="1459636.NTE_00250"/>
    <dbReference type="GeneID" id="43502550"/>
    <dbReference type="KEGG" id="nev:NTE_00250"/>
    <dbReference type="HOGENOM" id="CLU_3038860_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="54" mass="6015" checksum="51A0F96BFC7D4D62" modified="2014-10-29" version="1">MSSMMNADIEGAKLGVEVVIRHVSAHADFRGKIMQLDKDCTICQNYFADELAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNN3</accession>
    <name>A0A075MNN3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385035.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNN3"/>
    <dbReference type="STRING" id="1459636.NTE_00650"/>
    <dbReference type="GeneID" id="43502574"/>
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    <dbReference type="OrthoDB" id="11604at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="58" mass="6683" checksum="423551290C98786A" modified="2014-10-29" version="1">MAPEHGEFDSQSQKKWFCGYWMMQEEWEDIHDYAPPNTGAAAATAEEDEEEEQEGEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNY1</accession>
    <name>A0A075MNY1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA pseudouridine(55) synthase</fullName>
            <ecNumber evidence="1">5.4.99.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NTE_00777</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.4.99.25" evidence="1"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699744.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNY1"/>
    <dbReference type="STRING" id="1459636.NTE_00777"/>
    <dbReference type="GeneID" id="41596628"/>
    <dbReference type="KEGG" id="nev:NTE_00777"/>
    <dbReference type="eggNOG" id="arCOG01015">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028780_2_0_2"/>
    <dbReference type="OrthoDB" id="10348at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160148">
        <property type="term" value="F:tRNA pseudouridine(55) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039894">
        <property type="entry name" value="Pus10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048741">
        <property type="entry name" value="Pus10-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055174">
        <property type="entry name" value="Pus10_THUMP_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21568">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE PUS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21568:SF0">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE PUS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21238">
        <property type="entry name" value="Pus10_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22023">
        <property type="entry name" value="Pus10_THUMP_arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pus10 THUMP" evidence="5">
        <location>
            <begin position="60"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Pus10-like C-terminal" evidence="4">
        <location>
            <begin position="158"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF82855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="389" mass="42573" checksum="8730B162D6159CBB" modified="2014-10-29" version="1">MADAAAPNALLLLLKEYQLCKHCLLRQAGGASAGSRSRKAPEGKKCYICKGLFERLDEVAKKALLATKQYRQFDTFLVGATLPTQLYEREDALRARLKIRGRESVKSQLTRELGTRLARMTSKKADYLRPDLAVSVVIGKNGEVEAAARARPLALLCRYVKRERGLPQKAEKCPLCLGKGCNLCDGTGLAAADQGSVEGIVAKHIMKITGGQAPKFSWIGSEDQSSLVLGRGRPFYVKVSDPKLRKPRRTRFAEAGIEGRVVEVLDDMPDTQARFAVKTRIACRCERAIATDDIKKLKKSLAGSQARFENRAKVAIKKIHSVQAKKTAAEGEFVLTIVADGGLPIKQFVGGEQYIEPNVSSLLNTKCECAAFDILKVDLLNTGNKLGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MP34</accession>
    <name>A0A075MP34_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00849</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_075055561.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MP34"/>
    <dbReference type="GeneID" id="41596692"/>
    <dbReference type="KEGG" id="nev:NTE_00849"/>
    <dbReference type="HOGENOM" id="CLU_2765845_0_0_2"/>
    <dbReference type="OrthoDB" id="372328at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="69" mass="7781" checksum="BE73A8F52567F703" modified="2014-10-29" version="1">MHVAITKKPESVRYTFTWCCMKMAGAKEKNMVRVTPDGSVELYDKKGELVDPDMTRCPFCKTAIVISHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MP53</accession>
    <name>A0A075MP53_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved hypothetical phage tail region protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699524.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MP53"/>
    <dbReference type="STRING" id="1459636.NTE_00496"/>
    <dbReference type="GeneID" id="41596369"/>
    <dbReference type="KEGG" id="nev:NTE_00496"/>
    <dbReference type="eggNOG" id="arCOG11413">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101335_2_0_2"/>
    <dbReference type="OrthoDB" id="372229at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011747">
        <property type="entry name" value="CHP02241"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010667">
        <property type="entry name" value="Phage_T4_Gp19"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02241">
        <property type="entry name" value="conserved hypothetical phage tail region protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38009">
        <property type="entry name" value="CONSERVED HYPOTHETICAL PHAGE TAIL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38009:SF1">
        <property type="entry name" value="CONSERVED HYPOTHETICAL PHAGE TAIL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06841">
        <property type="entry name" value="Phage_T4_gp19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="170" mass="19261" checksum="8389A2AF232251DF" modified="2014-10-29" version="1">MAQFEINAQRFDPYKNFKFRIKWDGKFVAGLSMMSALTRTTTSIEHREGGDPSMSRKSPGRTSYGAITLSRGVTHDLEFEKWANKVWNFGAGLGSEVSLKDFRKDIIIEVYNEAGQLAIAYKVYRCWVSEYQALPQLDAGGNAIAIQTLKLENEGWERDESVTEPNEPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MP97</accession>
    <name>A0A075MP97_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Integrase SSV1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_00958</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699881.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MP97"/>
    <dbReference type="GeneID" id="41596790"/>
    <dbReference type="KEGG" id="nev:NTE_00958"/>
    <dbReference type="eggNOG" id="arCOG01247">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1010487_0_0_2"/>
    <dbReference type="OrthoDB" id="12173at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031857">
        <property type="entry name" value="Integrase_SSV1_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16795">
        <property type="entry name" value="Phage_integr_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase SSV1 C-terminal" evidence="2">
        <location>
            <begin position="179"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF83033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="282" mass="33089" checksum="DAFD291043A61DDA" modified="2014-10-29" version="1">MHSNYDVEQATRPAIAITLDGFDAYLRKVLTSDKDITYLHARANKYQHVLTSCNASELLAMSHDMQRQTMRALSHLAKFNGCYETWQRIIKNHALHWRHTDDNFNFFEKEDINEMLDRIKQAIKVLPADCANTLVVATMLGLRADESCKAIGLIKQATKDYYNEERGILEHYRHKDLFIRRSKKAYISLVDDDLLTLAKQSSDSYHSIRSYLKRRKIPMPMRYCRKVFATYLRQHGIETEFIDLLQGRTPASIFGKHYYRPDFDKQAKRILRLLPELKKELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPD3</accession>
    <name>A0A075MPD3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Archaeal serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_00571</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699580.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPD3"/>
    <dbReference type="GeneID" id="41596438"/>
    <dbReference type="KEGG" id="nev:NTE_00571"/>
    <dbReference type="eggNOG" id="arCOG01937">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG02527">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_321766_0_0_2"/>
    <dbReference type="OrthoDB" id="2272at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15482">
        <property type="entry name" value="Sialidase_non-viral"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="ATP DEPENDENT LON PROTEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00830">
        <property type="entry name" value="ENDOLAPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="Sialidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lon proteolytic" evidence="3">
        <location>
            <begin position="94"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="50"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="325"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="721"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="325"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="727"/>
            <end position="739"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF82652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="900" mass="95406" checksum="9F0FFD6C75EAFF8F" modified="2014-10-29" version="1">MAFLIIITSFLAIFQYAFMTPVAASTQSNLTAASPALLAQEREGMFVSADQPSTSHHQTIAQKQQPPGISDGNNTGTSSGNASSSLLLSSPSSQAQSQSIPFLAVISDQATGTVFPGSGQVLKLMIDVREGRGDILVNTNIFSGGMWQNSARTAASVAQSLTQEDLSSKDVVLTIKSTNSTESEEMLRKFGGGVDGPSAGGAMTVLLVSELEGKAVNNYTAMTGTINPDGTIGPVGGIIEKAVAAGRYGAKVMLVPAGQSYYPEVSCQQQHPESSSSSSFDTPAKSNTCRLEEKSLSYVMEKQYGMKVIEVHDVRSALSYFQSDGGNGTTTTVQRSLQQQREEEKGLMPATIVSSNKNNSNDDDSILNLSNDDGFSSFFLTAEDVSSNAMMAASGNNVYAIWVDNSTGSLGSFDIFFARSTNGGDSFDRAVDLSAPIRNNGSIYGNSYSPQIAASGSSVYVTWIENVYAASQDRQDSHILFSKSDDGGRTFQGPFDISGGTSGIPEPESLSLAYPLYSSNPQIIAASGSNGEEGGGAAAAYVVWTVHPLIVPTAGAQQQQQQGRVGEGDIFFTRIGPDGSLLAEPVNLSNNTGESHSPRIGLSGSNVYVAWADDTRGDGEIFFRHISDNGLTLGPVVNISNNYLQDDKPQIATGVDGNNSSVYVIWQHSGRNETGATTGAIGFASSQDNGTTFSKPTSVMTTRIDPAIGPLHHLAITTTATTAGRNLDQQGNSNNNTDGRGNASSSNNSAYIVWSDGTIGNRNIYFSKSNATDNNNPFPYYYWTLSNNTGESILPEIAVSGSGNVYVVWMDDASGAYDIYFREANFTSATSNNDFEVTFSDTINISNTTAGNSVFPQIIAEGDNVYIAWEEHVISNNGSNNNGSAVDNVNSEIYFKKLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPK5</accession>
    <name>A0A075MPK5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Polyketide cyclase / dehydrase and lipid transport</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00995</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699909.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPK5"/>
    <dbReference type="STRING" id="1459636.NTE_00995"/>
    <dbReference type="GeneID" id="41596823"/>
    <dbReference type="KEGG" id="nev:NTE_00995"/>
    <dbReference type="eggNOG" id="arCOG04604">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1375563_0_0_2"/>
    <dbReference type="OrthoDB" id="10357at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="197" mass="22260" checksum="18867C7D0B65ABBA" modified="2014-10-29" version="1">MTVIKKSMEINAPVNEVFTYFARPEHMADQFPENMGLNVVPVEVKNGFGVGTIFRINGDFDGKRLEWDCETIEYIPLKKIVAKMIEGPFKRWQISVTFDELGERKANVTLEVDYDMPMGPLGGFLDKVKLSKIAERGMENGLLRVKALLEGTGSIPVYITLDAYRHIIKEKMEMNCSVSEAIVKIIKDRQEALAKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPL5</accession>
    <name>A0A075MPL5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385092.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPL5"/>
    <dbReference type="STRING" id="1459636.NTE_01006"/>
    <dbReference type="GeneID" id="43502585"/>
    <dbReference type="KEGG" id="nev:NTE_01006"/>
    <dbReference type="HOGENOM" id="CLU_3194329_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="45" mass="5105" checksum="72488F1C03C29F0B" modified="2014-10-29" version="1">MLIGQRSYVLVFALAIGFMFVMLPAATYNDISSKNTKEQHIMPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPL6</accession>
    <name>A0A075MPL6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA polymerase</fullName>
            <ecNumber evidence="7">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NTE_00682</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="7"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987135.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPL6"/>
    <dbReference type="STRING" id="1459636.NTE_00682"/>
    <dbReference type="GeneID" id="41596539"/>
    <dbReference type="KEGG" id="nev:NTE_00682"/>
    <dbReference type="eggNOG" id="arCOG15272">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000203_6_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.690:FF:000011">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1390">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.342.10">
        <property type="entry name" value="DNA Polymerase, chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050240">
        <property type="entry name" value="DNA_pol_type-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004417">
        <property type="entry name" value="PRK05761.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10322:SF20">
        <property type="entry name" value="DNA POLYMERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10322">
        <property type="entry name" value="DNA POLYMERASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 7" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="3 7 11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="10">
        <location>
            <begin position="128"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="9">
        <location>
            <begin position="456"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIF82762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="896" mass="101981" checksum="24F5924AE1F76619" modified="2014-10-29" version="1">MAQQEVFTQERRKRFDDLPEMPEDRPALLLSAVYSGEERKVYLKFYDPRDNVIYHWRDRTGHVPYAYSKIQYADTVDQIVAKETKYKVERMKKKDVIADQEIDVLKITAPDPLSIGGTDNSLREKVRCWEADIKYHENYLYDRGLIPGTYYVRHGDKIEQHMYKISDKVEFELKNLLWDKIKEEGEGGKEYRQYVTTWANLLNQPIPELKRVAVDIEVESEEGRMPTPRDHDRRVTAVGFAGSDGLRKVLVLGENMVDNGKPLVKEAEVCKNEKELLEKAFAIINSYPIILTFNGDDFDLPYLYARSQDARISSDGKAIPRDAVPIIIKKESFIKHGMQAEPVGIRHGIHIDLFRTFQNRSIQIYAFSRKYTEFTLNAICEALLEDSKLEFEGDISDLPMQTLAEYCMKDAELTFRLTSFGDNLLMKLLVVIARIGRLSVDDIARFGVNQWIRGILYYEHRQRNELIPRTDELHEKGTASTAAVIKEKKYRGGEVVEPTPGIHFNVVVLDFASLYPSIIKVHNLSYETINCVHPRCRETGKIEGTTHWVCQQRKGLSSLLIGSLRDLRVNYYKFLSKDKTLPAQERQLYNVVSQAIKVILNASYGVMGAEIFPLYCLPVADATAAIGRNTINATIDKCKELGIEVVYGDTDSLFLKEPSQESINKVVGWAKDQLGVDLEIDKQYRYVVFSDLKKNYLGVLPDGTVDVKGLTGKKSHTPPFIRNAFYEILNILGRVGSQKDFESAKESIKNIIQRDAKNLEAHKIPTPDLSFNVMINKSLASYGKKVNSVKTMDGKASQIETYKGLPQHIKAAKLLADRGKEIKAGDIISYVKTKNGDGVKPVELAKPEEIDTEKYLEAMESTFDQVLGALSFDFKSVLGKPRQQSLDELFWSKPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPR8</accession>
    <name>A0A075MPR8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ketosteroid isomerase-like enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00769</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPR8"/>
    <dbReference type="KEGG" id="nev:NTE_00769"/>
    <dbReference type="HOGENOM" id="CLU_137417_3_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="13"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="97" mass="10243" checksum="5FD63DE2B6D7C1F4" modified="2014-10-29" version="1">MEQQQPNPLETIKNLIAAINQGDLDAASSLYDPEAVIIAQPGNIARGRDAIRAALQGFISLKPLLKGEADQVIEAGGTALYISRWTLVGTSPDGKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPS7</accession>
    <name>A0A075MPS7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ArnR1-like winged helix-turn-helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01503</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPS7"/>
    <dbReference type="KEGG" id="nev:NTE_01503"/>
    <dbReference type="HOGENOM" id="CLU_2504799_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038723">
        <property type="entry name" value="ArnR1-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14947">
        <property type="entry name" value="HTH_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ArnR1-like winged helix-turn-helix" evidence="1">
        <location>
            <begin position="2"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="85" mass="9186" checksum="48B57859BF7FB33B" modified="2014-10-29" version="1">MVLKLLSAINGGSEENQLESAAGISSKQLSRYLKEFIKDGLVGYAVSDGKTLVITEKGSRFLISYERVAASQAEHESPKGLLDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQ25</accession>
    <name>A0A075MQ25_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00891</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQ25"/>
    <dbReference type="STRING" id="1459636.NTE_00891"/>
    <dbReference type="KEGG" id="nev:NTE_00891"/>
    <dbReference type="HOGENOM" id="CLU_211279_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="42" mass="4781" checksum="93C4A1C56E05CD85" modified="2014-10-29" version="1">MLKRLARMYESGLSIQEISKQLDIGERSAKRILELLGYAVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQ96</accession>
    <name>A0A075MQ96_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">L-alanine aminotransferase apoenzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NTE_00982</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699899.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQ96"/>
    <dbReference type="STRING" id="1459636.NTE_00982"/>
    <dbReference type="GeneID" id="41596811"/>
    <dbReference type="KEGG" id="nev:NTE_00982"/>
    <dbReference type="eggNOG" id="arCOG01131">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_4_2_2"/>
    <dbReference type="OrthoDB" id="372018at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051926">
        <property type="entry name" value="Ala_Aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006230">
        <property type="entry name" value="PRK08363.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43488">
        <property type="entry name" value="GLUTAMATE-PYRUVATE AMINOTRANSFERASE ALAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43488:SF2">
        <property type="entry name" value="GLUTAMATE-PYRUVATE AMINOTRANSFERASE ALAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="5">
        <location>
            <begin position="30"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF83057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="392" mass="44155" checksum="27E0C4A02A6865CE" modified="2014-10-29" version="1">MKVSDRTHGVEYAIRDITAYANKFRAQGKEIIYLNIGDPVKFDFPTPEHIKRALTDAVNKNENYYADSEGLPELRKAIVEKESEKGLDVTEDDVLVTNGVSEGLDMALASIVDPNSEVLMPGPYYPPYSSYVKFYGGKPVEFRLHEDGRPDLEDLRKKITPRSRALCIISPNNPTGEVFDRKSLQQLIDIATEHDLYVICDEIYDKITFDSTFTGIGKVAKDAPVVLLNGFSKAYLMTGWRCGYICMNSGSRKLDQFREDVPKLARVRIATNLPVQIAAVQALRGPQDHIPVMVEKLRKRRDLVVKRLNGIGIQCKVPRGAFYAFPKIDLGNRWKDDKHFVIELLNSTGVLTVHGSGFGTSYGSGHFRIVYLPPEDVLEKAMDKLEKFVKSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQB4</accession>
    <name>A0A075MQB4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Response regulator with CheY-like receiver, AAA-type ATPase, and DNA-binding domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
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    <dbReference type="KEGG" id="nev:NTE_01320"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="3"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="179" mass="20159" checksum="29ED74CB051945DA" modified="2014-10-29" version="1">MKRVLIAENNKSDLAFYESTLLKSGYHVLIAADAKECLEKYKSELEQACAVAANEDSSTVRILPFDAVILNHTVSYREDGLQAAKEILLANLHQRIVFVSDSVQYTVELQNELYDRVEIIQKPFEPEALVELLESTEVYRALGSLGLNVQKLKECNLNHSQLLELLDACMTLLEEKTGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQL6</accession>
    <name>A0A075MQL6_9ARCH</name>
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        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">NTE_01765</name>
    </gene>
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            <taxon>Nitrososphaerota</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
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    </dbReference>
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    <dbReference type="GeneID" id="41597535"/>
    <dbReference type="KEGG" id="nev:NTE_01765"/>
    <dbReference type="HOGENOM" id="CLU_1253623_0_0_2"/>
    <dbReference type="OrthoDB" id="10137at2157"/>
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    </dbReference>
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        <location>
            <begin position="70"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="220" mass="24608" checksum="2B917EA9D69087C4" modified="2014-10-29" version="1">MSAGSSEARFTINVKEGIVELEGKESFVDKHLEKFEEIFKMAVKEAIASGMQQQNIALKAQVALPHEVHEMPSSQQQMPDGHAAAAPRQAAATPAPPSAKQHAPRVAPTLPPIPVDLKANESKPGLREFYAEKKPQNHYEKTAVFAYYITKFNKQQEVKFGEILSCYEEVNEKKPSVTDIVKNSVRYKGWLEQGSDRFSTRLTISGENYVKFDMPKKETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQQ9</accession>
    <name>A0A075MQQ9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_01357</name>
    </gene>
    <organism evidence="3 4">
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83425.1"/>
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    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="41597155"/>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF83425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="106" mass="11366" checksum="2BEA9A489C741DE0" modified="2014-10-29" version="1">MIRRKIFFESVAQKYNRALVPAFIITIVMVSIAFFAFSNQSAIQEQLTTFASADVVQEAEARSIASEGDTASSITCVKGGLPNRTLTPDEVCGEPGPDVRPTLGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MR35</accession>
    <name>A0A075MR35_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01497</name>
    </gene>
    <organism evidence="1 2">
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        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
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            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
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            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MR35"/>
    <dbReference type="STRING" id="1459636.NTE_01497"/>
    <dbReference type="KEGG" id="nev:NTE_01497"/>
    <dbReference type="HOGENOM" id="CLU_161116_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="127" mass="14361" checksum="00C4DF84FC3A418D" modified="2014-10-29" version="1">MAAHKVSICFIQHEPSRLIRCNAILYDMVARKASRNSSAKEQLKKVSPRTRSAAQIIKDQLRSVTTAIEDRVAIDDHVNNISHEMEYLLDSIDSIPKVSQKKILIAYKNFLKENLDAVESRLGKAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MR52</accession>
    <name>A0A075MR52_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyl hydrolase family 14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01615</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700406.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MR52"/>
    <dbReference type="STRING" id="1459636.NTE_01615"/>
    <dbReference type="GeneID" id="41597393"/>
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    <dbReference type="eggNOG" id="arCOG08751">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2152486_0_0_2"/>
    <dbReference type="OrthoDB" id="6843at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="108" mass="12559" checksum="0DD6AED32779BDC5" modified="2014-10-29" version="1">MTLEELRNKAFFQNTIDVWIAYCEEQKRDWYDTDAYRRFIQHLNANGIKMQKFPLCIKESGGMYERGRDKTQFLEELSKMSSDDAAAYTIKLSENVLAAIRSFTTAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MR78</accession>
    <name>A0A075MR78_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase, aryl-alcohol dehydrogenase like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700106.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MR78"/>
    <dbReference type="STRING" id="1459636.NTE_01247"/>
    <dbReference type="GeneID" id="41597053"/>
    <dbReference type="KEGG" id="nev:NTE_01247"/>
    <dbReference type="eggNOG" id="arCOG01617">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_3_2"/>
    <dbReference type="OrthoDB" id="28487at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd19086">
        <property type="entry name" value="AKR_AKR11C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053135">
        <property type="entry name" value="AKR2_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43312">
        <property type="entry name" value="D-THREO-ALDOSE 1-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43312:SF1">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="1">
        <location>
            <begin position="15"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="330" mass="37310" checksum="80AF79A6FC987B9A" modified="2014-10-29" version="1">MKYRRLGKSDLKVSEIGFGAWTIGLDWWGKKIDDAEAIRMLKKAYDVGINFYETADMYGKGKSERLMGEAFKDMRNEVVYSTKWGYDLYGAEQVGHQELPQKHDPEFLQVALKKSLERLQTDYVDVYSLHNPKMDAIQNDELFASLDDLVKKGTIKSHGVALGPAIGWRDEGLFSITNRNVTCVQTVYNVLEQDPGRDLMKAAAQNDVGIMVRVPDASGLLTGKVTADTKFDKNDHRSFRKQEFIKEAMQKIDNMKPLASNKGWNITELAIKFILSQQQISVVLPTMVSIEEIEMFATISDGKYLSASEAAQLEEMYEKNFYVKPSVASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MR88</accession>
    <name>A0A075MR88_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01547</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385231.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MR88"/>
    <dbReference type="STRING" id="1459636.NTE_01547"/>
    <dbReference type="GeneID" id="43502612"/>
    <dbReference type="KEGG" id="nev:NTE_01547"/>
    <dbReference type="HOGENOM" id="CLU_2968574_0_0_2"/>
    <dbReference type="OrthoDB" id="5701at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="58" mass="6379" checksum="1B5FA47ED69A1252" modified="2014-10-29" version="1">MAIKKIKCDCGKFIEYTDRVVGGQNAQSGTLVCAKCGKEHQITFLGFLSEIKNASLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRB3</accession>
    <name>A0A075MRB3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02039</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385327.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRB3"/>
    <dbReference type="GeneID" id="43502636"/>
    <dbReference type="KEGG" id="nev:NTE_02039"/>
    <dbReference type="HOGENOM" id="CLU_2820605_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="66" mass="6844" checksum="C0A1F8FDD4D7A1F8" modified="2014-10-29" version="1">MFHRIAQKTASLVAKHPQITMMAVSVGAALVLGAIVASLDGGQAWASSSSSSPPHKCPVLPRCINF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRK7</accession>
    <name>A0A075MRK7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRK7"/>
    <dbReference type="KEGG" id="nev:NTE_02121"/>
    <dbReference type="HOGENOM" id="CLU_3245174_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="42" mass="4685" checksum="05B6E58D3AA6F0F6" modified="2014-10-29" version="1">MSIDPFVRGDNKGILIFGLVATIFPIVFVIFAVLPDLPRLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRS4</accession>
    <name>A0A075MRS4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01458</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRS4"/>
    <dbReference type="STRING" id="1459636.NTE_01458"/>
    <dbReference type="KEGG" id="nev:NTE_01458"/>
    <dbReference type="eggNOG" id="arCOG10549">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1976608_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="134" mass="14559" checksum="E8090007BA31E901" modified="2014-10-29" version="1">MRIFALYTVRVIIAVAVAVAIGVAFAGYFAYTWLSRPQYALEVDATRDTTDISGTLYRIRVANVGLARLTNVSAEMGAGDVQTKDFLDPGQTYYFYPNPDTLAPTIKVTSDEGIKVVTDYRTPTKVLGLPGGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRZ6</accession>
    <name>A0A075MRZ6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Flavin-dependent oxidoreductase, F420-dependent methylene-tetrahydromethanopterin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_01814</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700570.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRZ6"/>
    <dbReference type="STRING" id="1459636.NTE_01814"/>
    <dbReference type="GeneID" id="41597579"/>
    <dbReference type="KEGG" id="nev:NTE_01814"/>
    <dbReference type="eggNOG" id="arCOG02410">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027853_5_0_2"/>
    <dbReference type="OrthoDB" id="194060at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01097">
        <property type="entry name" value="Tetrahydromethanopterin_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="entry name" value="Luciferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050564">
        <property type="entry name" value="F420-G6PD/mer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43244">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43244:SF1">
        <property type="entry name" value="5,10-METHYLENETETRAHYDROMETHANOPTERIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="Bacterial luciferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Luciferase-like" evidence="2">
        <location>
            <begin position="29"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF83875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="326" mass="35697" checksum="1B6E94B02B6348EC" modified="2014-10-29" version="1">MKIGYSLGPLLSMEDVLRCASLADGHENVDSVWVPESWGRESFSTLGAVAQTTKRVRLGTSIISIFSRTPATIAMGAATLDMVSSNRTIIGLGTSTEAIVENWHGVEFEKPASRMKEYVECIRLMASGERVNYSGEFFKVSNFKMLNAPPRKHVPIFLAAVNRRMLALAAEKADGVLLYMRPLEELEKMVPELKERATASNFEVALSLICAVSDKEPEKARARAAKTLAFYVAVGKYYSKFLAENGYSDEVKHISEAYQKGGGDAAAEHVSPRMLEALTVCGTKDECRKALSRFSGSGVTLPILQFNPVQDAESSFRELLSTFSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MS17</accession>
    <name>A0A075MS17_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MS17"/>
    <dbReference type="STRING" id="1459636.NTE_01840"/>
    <dbReference type="GeneID" id="41597604"/>
    <dbReference type="KEGG" id="nev:NTE_01840"/>
    <dbReference type="HOGENOM" id="CLU_2747966_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="70" mass="7470" checksum="105344307E5958F6" modified="2014-10-29" version="1">MALWQRLEEFAYSHPTVAAFAIAIVAVSAIALAFSVFAAATGNTHYLHNDVARVAFHTTTASSRPGCLYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MS94</accession>
    <name>A0A075MS94_9ARCH</name>
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        <submittedName>
            <fullName evidence="1">Sigma-54 interacting regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01614</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MS94"/>
    <dbReference type="STRING" id="1459636.NTE_01614"/>
    <dbReference type="GeneID" id="41597392"/>
    <dbReference type="KEGG" id="nev:NTE_01614"/>
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1149844_0_0_2"/>
    <dbReference type="OrthoDB" id="9837at2157"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="245" mass="27860" checksum="E1155F8C179EAA9F" modified="2014-10-29" version="1">MSEDLPVGVSEEEGEFSEHRVVKTADLQQQGLPVSFDSIVGYDDVKRLFQMSLSSDKPVHMLLVGPPASAKTLFMLECMKLERSYFTLGSHSTKSGMIDYLFEKRPRYLIVDEIEHMPMKDQTALLSLMETGIVAETKFQKTRNTQLKTWVFATSNGTERMLTPLLSRFIVLHFKQYSLGSFTEICTHLLAREGIAPDIAATVADAVWNKLKSKDIRDCVKLGRLAKTKEDVDWIAQTMRNYKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSD2</accession>
    <name>A0A075MSD2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSD2"/>
    <dbReference type="STRING" id="1459636.NTE_02011"/>
    <dbReference type="KEGG" id="nev:NTE_02011"/>
    <dbReference type="HOGENOM" id="CLU_3002961_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="56" mass="6067" checksum="4F0F2D28221DCD52" modified="2014-10-29" version="1">MNIAASDVHQPPSSNENNRAEAITPLVKRVPETPAYEAELKSSMLLYLEGGGKLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSI4</accession>
    <name>A0A075MSI4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01691</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSI4"/>
    <dbReference type="STRING" id="1459636.NTE_01691"/>
    <dbReference type="KEGG" id="nev:NTE_01691"/>
    <dbReference type="HOGENOM" id="CLU_3020783_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="55" mass="6449" checksum="F6E4C7FEC1B809D7" modified="2014-10-29" version="1">MQRHSQPKKLDGRKKHNRYFPFLLIIDNFAATATLICYSVVKYTHTWNVQEGPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSN6</accession>
    <name>A0A075MSN6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02544</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701134.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSN6"/>
    <dbReference type="STRING" id="1459636.NTE_02544"/>
    <dbReference type="GeneID" id="41598240"/>
    <dbReference type="KEGG" id="nev:NTE_02544"/>
    <dbReference type="HOGENOM" id="CLU_2930031_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="60" mass="7437" checksum="DD47BE540BD515FB" modified="2014-10-29" version="1">MVRGIRMGRPRKKKQEKRTFSRTEWERIRREMPSFNEQELKEFFDFPRIVADPKMDSGYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSZ5</accession>
    <name>A0A075MSZ5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TPR repeat</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_02261</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987272.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSZ5"/>
    <dbReference type="STRING" id="1459636.NTE_02261"/>
    <dbReference type="GeneID" id="41597976"/>
    <dbReference type="KEGG" id="nev:NTE_02261"/>
    <dbReference type="eggNOG" id="arCOG03032">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_736967_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051685">
        <property type="entry name" value="Ycf3/AcsC/BcsC/TPR_MFPF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF047558">
        <property type="entry name" value="TPR_END_plus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44943">
        <property type="entry name" value="CELLULOSE SYNTHASE OPERON PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44943:SF4">
        <property type="entry name" value="TPR REPEAT-CONTAINING PROTEIN MJ0798"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="35"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="69"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="103"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF84315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="376" mass="43062" checksum="1ECDB723BFBF4963" modified="2014-10-29" version="1">MGRFFGKGNSSSKKDEEARSEREQVPNYSDAEFQKRDLFKKGQNYMSNDKMLDAVRCFELALRIDPKYVDAWVKKGYAHFHMSEYTVAISSYDRALEVDVNNAEAWNLKGLAYYKLKNHEKAIECCEKAIDIDPNDGMAWYNRACYLTLSGKVDEGLESLKRSIEIDIANARKAVKDRDFENARAEEGFRRIIEVVVLESIRQGYDYVGKIVWLTGIDKIEVEDAIMRLTMKGLLTKREKRNITGMEEYYEITRDIAAKIGVTKRVGLFGKEKQVSAPVQQLKDISEVLGKAKEAVEHGDLEATKQCFDELISPAKHGSAMIEQFFEEHRDLRLAQIKLRDRGQEYLNANKAAMIDMIGRIDMKVRQGPVTKPAKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSZ9</accession>
    <name>A0A075MSZ9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700841.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSZ9"/>
    <dbReference type="GeneID" id="41597898"/>
    <dbReference type="KEGG" id="nev:NTE_02174"/>
    <dbReference type="eggNOG" id="arCOG02777">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_163108_0_0_2"/>
    <dbReference type="OrthoDB" id="374950at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="97" mass="10718" checksum="E132FD8E7CFDD93A" modified="2014-10-29" version="1">MVPTDVTGSAITVKCVACDRKGINKISLAAVLKRNKFLLGVIFGYWMFAIFPLPFLQLGGYEATAIVLQPVLFATAILTIPFVFMIIAWQKRAPKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MT16</accession>
    <name>A0A075MT16_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, AsnC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02297</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700934.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MT16"/>
    <dbReference type="STRING" id="1459636.NTE_02297"/>
    <dbReference type="GeneID" id="41598012"/>
    <dbReference type="KEGG" id="nev:NTE_02297"/>
    <dbReference type="eggNOG" id="arCOG01117">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_170329_2_0_2"/>
    <dbReference type="OrthoDB" id="8136at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription regulator AsnC/Lrp ligand binding" evidence="1">
        <location>
            <begin position="6"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="83" mass="9400" checksum="67A1B48380A01061" modified="2014-10-29" version="1">MPTAYVLINCDLGSEEEIIRELKKMPGTIEVSGVYGVYDIIAKVSSDSMEKLRETITWHVRKIDKVRSTLTMIVIEGQGEKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MT45</accession>
    <name>A0A075MT45_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700966.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MT45"/>
    <dbReference type="STRING" id="1459636.NTE_02332"/>
    <dbReference type="GeneID" id="41598048"/>
    <dbReference type="KEGG" id="nev:NTE_02332"/>
    <dbReference type="eggNOG" id="arCOG10526">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1003322_0_0_2"/>
    <dbReference type="OrthoDB" id="10659at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="277" mass="29793" checksum="D8055A1EDB037F41" modified="2014-10-29" version="1">MHGRGAFDPASVRRRLAGTIALATVVATLLIVFSGDDLRPFFTNWTINIAAGAALGMALVASFRQGAGGLYGKTTAAFAFGLALWFAAELLWTYYQLGAGIEVPYPSPADALWMAGYGPMAYHLLKTYRFFSAGKKTLALVVAVTSAFVAYTCMAVVGASVQVGGGGEEPLALALSLAYVVLDGLLLAPAVMLLANFRRGKLTSTPWAFLSASLAIFAVADVGFAYYTASGLDGLIWHWDPLYNASYIIMAATLFWHNRFFIFDKGRAKKIWQQDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MT64</accession>
    <name>A0A075MT64_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02254</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MT64"/>
    <dbReference type="STRING" id="1459636.NTE_02254"/>
    <dbReference type="KEGG" id="nev:NTE_02254"/>
    <dbReference type="HOGENOM" id="CLU_1275365_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="215" mass="24331" checksum="A1C5B11E3411A368" modified="2014-10-29" version="1">MSLVEQRLLSQKERLKIESRLANYRIPIQILQLVAEECNCGDVVSGTREVHGRSKKPSLISRMNDQSLIQLKQIFLDCDDSSSRFRFAVLLSTKFPPVSYKFVLSDKLHGRSDQEYIFDVCIFSRSTEELVAVGMQNNDASRSATDAKSLNNFLSIMNDVFAAYPSVRSAYYSSSYGYDCSPSNLATKKQLGASTDNTEINFLEFRDGVYREIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MT84</accession>
    <name>A0A075MT84_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02719</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MT84"/>
    <dbReference type="STRING" id="1459636.NTE_02719"/>
    <dbReference type="KEGG" id="nev:NTE_02719"/>
    <dbReference type="HOGENOM" id="CLU_1965639_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="129" mass="14893" checksum="5F38FEFBD6C1D397" modified="2014-10-29" version="1">MLGKSSSEVQQKPVAEELWYADLAKLSNDELMRMYTMIKDGRYEFAKNAWYIPIGGDQRCPIMVAKGFRSPDTLAKMAEFQDTAKILEGEYRNFIDAWDFGYITTKDIEKAVLKILEERNIEIAERSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTC8</accession>
    <name>A0A075MTC8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LSU ribosomal protein L30P</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_02796</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701344.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTC8"/>
    <dbReference type="STRING" id="1459636.NTE_02796"/>
    <dbReference type="GeneID" id="41598484"/>
    <dbReference type="KEGG" id="nev:NTE_02796"/>
    <dbReference type="eggNOG" id="arCOG04086">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055156_6_0_2"/>
    <dbReference type="OrthoDB" id="6379at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01657">
        <property type="entry name" value="Ribosomal_L7_archeal_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.15.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="entry name" value="Ribosomal protein L30, ferredoxin-like fold domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="Ribo_uL30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039699">
        <property type="entry name" value="Ribosomal_uL30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035808">
        <property type="entry name" value="Ribosomal_uL30_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_uL30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004711">
        <property type="entry name" value="PRK06049.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="Ribosomal protein L30p/L7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL30-like ferredoxin-like fold" evidence="4">
        <location>
            <begin position="3"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF84836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="152" mass="16931" checksum="9F40649F05ED57C1" modified="2014-10-29" version="1">MAYLVVRIKGTVNIPAWAKTTLDNLNLDRRFRATLVPESDESLGMLRKVKEVVAWTKADAATVKELLEKRGRKAGYKPITKADLPKEYKSIDELASAIADNKIAMSKVEGIKPWFALSPPKGGFKRKTKQQYSQAGVLGDDEGLVEIVKRML</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTH0</accession>
    <name>A0A075MTH0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribbon-helix-helix protein, copG family</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02868</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_193354074.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTH0"/>
    <dbReference type="STRING" id="1459636.NTE_02868"/>
    <dbReference type="GeneID" id="59387792"/>
    <dbReference type="KEGG" id="nev:NTE_02868"/>
    <dbReference type="HOGENOM" id="CLU_3094244_0_0_2"/>
    <dbReference type="OrthoDB" id="7535at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="51" mass="5683" checksum="CAFD0D5C0ED1F227" modified="2014-10-29" version="1">MQATTIPEEQGKRTMPICFTPDQLKVVEEYAKKKGMLNASQAIEELLLAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTI3</accession>
    <name>A0A075MTI3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02888</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701414.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTI3"/>
    <dbReference type="STRING" id="1459636.NTE_02888"/>
    <dbReference type="GeneID" id="41598567"/>
    <dbReference type="KEGG" id="nev:NTE_02888"/>
    <dbReference type="HOGENOM" id="CLU_1933332_0_0_2"/>
    <dbReference type="OrthoDB" id="10666at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="133" mass="14833" checksum="B20F0ACFD3CD2B77" modified="2014-10-29" version="1">MQIRHCVEEANVDKEDMKVIDPTQVRHVTVLAGKIDSMSGLVDPASHLNLDFPDHRVTTCIIAEKFEKGAPVQMDDNGMIFATVDRSAYKHYGTVDYTQRLTDMIKAVQKKGMMMAETKSSSASDKKKKGLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTM6</accession>
    <name>A0A075MTM6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00558</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTM6"/>
    <dbReference type="STRING" id="1459636.NTE_00558"/>
    <dbReference type="KEGG" id="nev:NTE_00558"/>
    <dbReference type="eggNOG" id="ENOG502N59M">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_395177_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="697" mass="73974" checksum="C427359804E19967" modified="2014-10-29" version="1">MLYYKVYGTYFQRQDKSELPYTMVKSPKSGHTIMSLTNNCDIFAAIHDEGINRVIRHIMRQRPSLFNYGTSLVASNPQLLCERIDAAPEVIRNRNPLVTVLDPLPVIGLSGLPQDTSLGPTNLGLNFGVQLSKGEMDFFRGNVFSLPPELSPLASQRLAVHFRVCAGIGCPSKEIVLPGKLATTSSSLSTFASSFARERRIISNSNAALQDILGPHAGASLPGRDGDNSNITLPATRLECFCLDLFATAGCKITGLVGNQRIEPRVDGIEIVDLKPEGMENAIECYARLVLNHGIFPPVAEFISKLAFGLFELPSPNPGDDVQVSGDIQVSASTAVPNNPAIEDDQLKTFINLDKVDLDIVISPSGSGGGGSGGGGGGGGGTITRTVRPRTRTGTFDLTAAISEQAFKEIYGAVIKGFKFVKSGTGSSGIFTASYSVAAHLEGGTIDLRSSGSIVVSELDVKWDTLHVNIGIDIPTVTIGGFCIIPNPFGGCLVRAPSIDLFSGSPDISIPLDLSGIITSEITFSAIPKVFYGVGSGGLSNRWQITLVPTLPIDLDIIDIADTAGDLFHNLIVDAIDNLLGSLGLPDWAIDFIDFVLGGIEGIIRTVLDIPDDVGEFLLDLIGNLGIFQALIDAISQYIAITLFELEDPLEVLPANPVPTPANPVAPLIPVKIPIEFLGIRVNSGGNEMIVEGDVGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTR3</accession>
    <name>A0A075MTR3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyrroloquinoline quinone (Coenzyme PQQ) biosynthesis protein C</fullName>
            <ecNumber evidence="2">1.3.3.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02527</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.3.3.11" evidence="2"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226986980.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTR3"/>
    <dbReference type="STRING" id="1459636.NTE_02527"/>
    <dbReference type="GeneID" id="41598228"/>
    <dbReference type="KEGG" id="nev:NTE_02527"/>
    <dbReference type="eggNOG" id="arCOG01128">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088144_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033732">
        <property type="term" value="F:pyrroloquinoline-quinone synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039068">
        <property type="entry name" value="PqqC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40279:SF3">
        <property type="entry name" value="4-AMINOBENZOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40279">
        <property type="entry name" value="PQQC-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14518">
        <property type="entry name" value="Haem_oxygenas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01236">
        <property type="entry name" value="Haem_oxygenase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="232" mass="26108" checksum="44EC28F0C1360872" modified="2014-10-29" version="1">MAFEVRYNMENYDLVERIDSEIENRSLLKHPFYQMWSEGRLTVDHLQGYSKEYFQLVKAVPAFVQNIASAANNTDPSKVPGIKENLKEESEHIEPWARFAGAMGVSQSELASYAGAAKTNDAVAKMMSLTLLSFEEAVAAMYAFEAELPKISRSKIDGLAKFYGMTGNKDALNYFEIHEDADVRHAQVWRDILQAVPAEKREKAFAAAVESLKAQNLLLDSVQEKYVGSMYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTS6</accession>
    <name>A0A075MTS6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02543</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTS6"/>
    <dbReference type="STRING" id="1459636.NTE_02543"/>
    <dbReference type="KEGG" id="nev:NTE_02543"/>
    <dbReference type="HOGENOM" id="CLU_3338261_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="37" mass="4324" checksum="8B77FF6F973D79C7" modified="2014-10-29" version="1">MNKLTIPPIMEREEALERVALFLIAKEVSVLRKWLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTT0</accession>
    <name>A0A075MTT0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Geranylgeranyl pyrophosphate synthase</fullName>
            <ecNumber evidence="7">2.5.1.90</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NTE_02548</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.90" evidence="7"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701136.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTT0"/>
    <dbReference type="STRING" id="1459636.NTE_02548"/>
    <dbReference type="GeneID" id="41598243"/>
    <dbReference type="KEGG" id="nev:NTE_02548"/>
    <dbReference type="eggNOG" id="arCOG01727">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014015_2_0_2"/>
    <dbReference type="OrthoDB" id="106922at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106350">
        <property type="term" value="F:all-trans-octaprenyl-diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF85">
        <property type="entry name" value="SHORT CHAIN ISOPRENYL DIPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF84595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="287" mass="32377" checksum="6DDEE0DA3DC69F3B" modified="2014-10-29" version="1">MGRRNIEANPLTDLCGDYLVRIEDALKRELDSYSWSEFHAPLRYACDGGKRIRPLILVLSAEAIKGKKANGDAYLAASAIELLHTESIIHDDIIDEEHTRRGKPSFHVKYGYNSSILTADFVLGVILFIGSKLKNPRVLNELSNAATRMSEGEMMEIRLNKAPAITEDDYIKVLDYKTASLFETSAKIGAILGEGTEEQIHAMTTFGHMLGIAYQIHDDLIDWNDEDKLFNMLVKQNDRSKDFIDRMEKLYQSYAAKAKDELLKVAPANNEVIRHLELMTDLASVQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTT9</accession>
    <name>A0A075MTT9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PRC-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03006</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701511.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTT9"/>
    <dbReference type="STRING" id="1459636.NTE_03006"/>
    <dbReference type="GeneID" id="41598676"/>
    <dbReference type="KEGG" id="nev:NTE_03006"/>
    <dbReference type="HOGENOM" id="CLU_198710_0_0_2"/>
    <dbReference type="OrthoDB" id="8759at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="77" mass="8418" checksum="1BB07D4ED8215512" modified="2014-10-29" version="1">MQSSEPAVLRWDRVIHKGVRTKDGLPLGNIASEEPDAIVVLGIKSRVYKIPKSRVESFDGSQVLVDIPAKETGGYLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTV4</accession>
    <name>A0A075MTV4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385374.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTV4"/>
    <dbReference type="GeneID" id="43502640"/>
    <dbReference type="KEGG" id="nev:NTE_02138"/>
    <dbReference type="HOGENOM" id="CLU_3178399_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="10"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="46" mass="4951" checksum="748E9434953D30FA" modified="2014-10-29" version="1">MSSDAAADVTSCPQCGMVFDSVESLREHLKKEEEQAVLHTNEDAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTZ2</accession>
    <name>A0A075MTZ2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00639</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699634.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTZ2"/>
    <dbReference type="STRING" id="1459636.NTE_00639"/>
    <dbReference type="GeneID" id="41596502"/>
    <dbReference type="KEGG" id="nev:NTE_00639"/>
    <dbReference type="eggNOG" id="arCOG08702">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_168727_0_0_2"/>
    <dbReference type="OrthoDB" id="9112at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002831">
        <property type="entry name" value="Tscrpt_reg_TrmB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01978">
        <property type="entry name" value="TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription regulator TrmB N-terminal" evidence="1">
        <location>
            <begin position="15"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="120" mass="13374" checksum="1F281B2A1517D7DF" modified="2014-10-29" version="1">MAVNLSNVEQAIIEELKISPEEARAYVAIVKSGKMDAARISKATGIGDEKQAQAVAKSLVGRGMVIEITAMEFESLHPRFAVTNRYRRRCAEDNIPFKKNLRVDNIGIVLEKPFEDARTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MU06</accession>
    <name>A0A075MU06_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699649.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MU06"/>
    <dbReference type="STRING" id="1459636.NTE_00659"/>
    <dbReference type="GeneID" id="41596520"/>
    <dbReference type="KEGG" id="nev:NTE_00659"/>
    <dbReference type="eggNOG" id="arCOG08750">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_175266_0_0_2"/>
    <dbReference type="OrthoDB" id="10082at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="120" mass="13033" checksum="EFCBD3357473D380" modified="2014-10-29" version="1">MGGKLYPREKKRKMDGSLKPVLKRQIMFLAASLGVGLVLTYFFGFLVGMAANIAIFVGAIFYIRYRQTKALGSFGFGSETAGRGHMSEGVKLKYVCLACGAEVKGTRCSSCGSNMKKPLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MU57</accession>
    <name>A0A075MU57_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">2,3-di-O-geranylgeranylglyceryl phosphate reductase</fullName>
            <ecNumber evidence="10">1.3.99.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NTE_02657</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SR1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.3.99.-" evidence="10"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701225.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MU57"/>
    <dbReference type="STRING" id="1459636.NTE_02657"/>
    <dbReference type="GeneID" id="41598349"/>
    <dbReference type="KEGG" id="nev:NTE_02657"/>
    <dbReference type="eggNOG" id="arCOG00570">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024648_0_0_2"/>
    <dbReference type="OrthoDB" id="6062at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050407">
        <property type="entry name" value="Geranylgeranyl_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054715">
        <property type="entry name" value="GGR_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42685:SF18">
        <property type="entry name" value="DIGERANYLGERANYLGLYCEROPHOSPHOLIPID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42685">
        <property type="entry name" value="GERANYLGERANYL DIPHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22578">
        <property type="entry name" value="GGR_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="Digeranylgeranylglycerophospholipid reductase catalytic" evidence="9">
        <location>
            <begin position="205"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIF84700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="484" mass="54206" checksum="53052E286030A308" modified="2014-10-29" version="1">MPGQRDYDIIVAGGGLAGMIVGTSAAYYSKQKLKILVIDRNAFPQQGMKTISGWVCGDAVGRNTVDYMAERIHINWGKPEIEHPVKGVVAFSPDHETKVAFDGEGYILNRKMLPQRQMADCKKMGVELKERVAIRSLIIENNAVIGVEGEDLASKTPFKKTAKLVVDCTGVTSVLRTNFPLKSYIERRIDRDDLEATGRYIYNFELANDDKTYFDPDYCIIHLDQKLAPGGYGWVFPKGKTKVNIGLGVQQKAFEARNKEMGVNPNLTTLINEYVQANPTIKNPTLADGEMDDGNAWGTWQVSVRRQNDCMVSNGYMLVGDSAWMPKPLDAGGIGPAIIAATIAGKDAVEAIEANDTSERNLWKYNKHFINDYGYKTAGLEVFRRMLQGLTNDQINYGMKHFLSKMDIDKITKGEHPEFSTVDKLGMMIRGAMNKKLAEDLRYCASINKKLTDHYYNYPETPDGFSAWQKTLHGMLQEAFAKYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MU90</accession>
    <name>A0A075MU90_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_02693</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701253.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MU90"/>
    <dbReference type="STRING" id="1459636.NTE_02693"/>
    <dbReference type="GeneID" id="41598382"/>
    <dbReference type="KEGG" id="nev:NTE_02693"/>
    <dbReference type="HOGENOM" id="CLU_2490278_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF84735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="86" mass="9374" checksum="F30E8A9532571D7E" modified="2014-10-29" version="1">MVKVQTPEKDDDGLIVSRLYPVKLVLDVPQPAPAQTEEEQPQSSSNNIPASSPFDIRDIIRVLAAAAAVGLVGYIVYTKIKGRKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MU98</accession>
    <name>A0A075MU98_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative transcriptional regulator, contains C-terminal CBS domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_03187</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701652.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MU98"/>
    <dbReference type="STRING" id="1459636.NTE_03187"/>
    <dbReference type="GeneID" id="41598843"/>
    <dbReference type="KEGG" id="nev:NTE_03187"/>
    <dbReference type="eggNOG" id="arCOG00601">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035203_0_0_2"/>
    <dbReference type="OrthoDB" id="9280at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd02205">
        <property type="entry name" value="CBS_pair_SF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.100">
        <property type="entry name" value="Ribosome hibernation promotion factor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051257">
        <property type="entry name" value="Diverse_CBS-Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036567">
        <property type="entry name" value="RHF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43080:SF2">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43080">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN CBSX3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69754">
        <property type="entry name" value="Ribosome binding protein Y (YfiA homologue)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="4">
        <location>
            <begin position="8"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="4">
        <location>
            <begin position="68"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="4">
        <location>
            <begin position="128"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="350"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="360"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF85216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="373" mass="40852" checksum="48483858383FC939" modified="2014-10-29" version="1">MMKVSDIMVADVASVASEDPVAKAFSVMIDRSINQLPLVDEDGRYSGMVFAKHLLSSSAPPTSKLKSYAVKTQALRPDEDVEKAAKMVLGSGNRALPVVGNGGRLAGIVSETDIAQTADFGHATVDEVMSGAIVIEEDTPLADAMSKMRRYNISRLPVINNKGLLRGVVNILDAASIVATPKERTSKSAAITGSKSRVQGDVKVKDIMRRAVSVERGTRMNELAEHFKRSEEVVVVGDGRPMGIVTPKDALELVLPKKDGPAIHMAHLEDDRDRREIEDQLLRFVKKIQGKLGDIQSVVVYADKHKTRKYSVRCRLITAKGVVNAKAVGYDPLSASKELIEKLDRQIKTEHTQKVKGRQHRETARKVEAEEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUC5</accession>
    <name>A0A075MUC5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein L30E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_02748</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701303.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUC5"/>
    <dbReference type="STRING" id="1459636.NTE_02748"/>
    <dbReference type="GeneID" id="41598437"/>
    <dbReference type="KEGG" id="nev:NTE_02748"/>
    <dbReference type="eggNOG" id="arCOG01752">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130502_1_0_2"/>
    <dbReference type="OrthoDB" id="10759at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039109">
        <property type="entry name" value="Ribosomal_eL30-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11449">
        <property type="entry name" value="RIBOSOMAL PROTEIN L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="3">
        <location>
            <begin position="3"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF84790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="104" mass="11071" checksum="7820ADCD5885DF5D" modified="2014-10-29" version="1">MKTIDKVIKDAVAANKYKSGVKEVLQSAKSSKLVIVSKSLDAGDRAKLDEQAKSAGVAIYEFDGNSVQLGKLCNKPFRITAIAIKGATDAEVKAVMADEEKKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUG1</accession>
    <name>A0A075MUG1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NTE_00878</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987157.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUG1"/>
    <dbReference type="STRING" id="1459636.NTE_00878"/>
    <dbReference type="GeneID" id="41596719"/>
    <dbReference type="KEGG" id="nev:NTE_00878"/>
    <dbReference type="eggNOG" id="arCOG01972">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090389_10_1_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45663">
        <property type="entry name" value="GEO12009P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45663:SF11">
        <property type="entry name" value="GEO12009P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Thioredoxin" evidence="5">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF82954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="131" mass="14628" checksum="111BFD5FAE8856A1" modified="2014-10-29" version="1">MARVNKMEFGRSGNNKEVTIDTPIALTDSNFEQALQKYPLLIVDFFAPWCGSCRMLVPTIEQMASEMAGKTVFGRLNVDENPRITSLFEVQSVPTVIIFRNGELLDGFRGVAPKAQIRSRIKSMIATIMSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUQ8</accession>
    <name>A0A075MUQ8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5'-monophosphate synthetase</fullName>
            <ecNumber evidence="10">6.3.4.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranosyl 5'-monophosphate--formate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">purP</name>
        <name evidence="13" type="ORF">NTE_02840</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + formate + ATP = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:24836"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="10">Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (formate route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.23" evidence="10"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUQ8"/>
    <dbReference type="STRING" id="1459636.NTE_02840"/>
    <dbReference type="KEGG" id="nev:NTE_02840"/>
    <dbReference type="eggNOG" id="arCOG04346">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065084_0_0_2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00134"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01163">
        <property type="entry name" value="IMP_biosynth_PurP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023656">
        <property type="entry name" value="IMP_biosynth_PurP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009720">
        <property type="entry name" value="IMP_biosynth_PurP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010672">
        <property type="entry name" value="IMP_biosynth_PurP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38147:SF2">
        <property type="entry name" value="5-FORMAMINOIMIDAZOLE-4-CARBOXAMIDE-1-(BETA)-D-RIBOFURANOSYL 5'-MONOPHOSPHATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38147">
        <property type="entry name" value="5-FORMAMINOIMIDAZOLE-4-CARBOXAMIDE-1-(BETA)-D-RIBOFURANOSYL 5'-MONOPHOSPHATE SYNTHETASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06849">
        <property type="entry name" value="DUF1246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06973">
        <property type="entry name" value="DUF1297"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004602">
        <property type="entry name" value="ATPgrasp_PurP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="12">
        <location>
            <begin position="113"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide</name>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide</name>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide</name>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIF84878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="351" mass="39292" checksum="2CB63AD7F250CB3C" modified="2014-10-29" version="1">MANTNNKAKKITTIATLGSHCALQVLKGAKDEGFRTLLVCEKKRVGLYERFGFIDDMIIVDKFSEVAGDRCKAALKKKDAIIIPHGTLISQMSSDEIEKIETPVFGNKWILRWEADREMKQKLMEEAGLRTPRPVQSKDKISGLCIVKLHGAAGGRGYYLAWNRESFEEGAKRLVQQGMIRGEQDLYIQEFIRGVPVYLQYFYSPVTKSLELLGVDRRYESDIDGIGRIPAKQQLGAGGEPSYTVVGNIPLVLRESLLDEVYKMGESFCRAAERLVKPGMPGPFCLEGVYDSEGRFTTFEFSARIVAGTNLYVDGSPYSGLLYDEPMSMGRRIAREVKMAKRKNCLSSIVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUT4</accession>
    <name>A0A075MUT4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Urease accessory protein UreG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ureG</name>
        <name evidence="8" type="ORF">NTE_02885</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer. UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701411.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUT4"/>
    <dbReference type="STRING" id="1459636.NTE_02885"/>
    <dbReference type="GeneID" id="41598564"/>
    <dbReference type="KEGG" id="nev:NTE_02885"/>
    <dbReference type="eggNOG" id="arCOG01231">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072144_1_0_2"/>
    <dbReference type="OrthoDB" id="812at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05540">
        <property type="entry name" value="UreG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01389">
        <property type="entry name" value="UreG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004400">
        <property type="entry name" value="UreG"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00101">
        <property type="entry name" value="ureG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31715">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31715:SF0">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005624">
        <property type="entry name" value="Ni-bind_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 6" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobW/HypB/UreG nucleotide-binding" evidence="7">
        <location>
            <begin position="13"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="18"/>
            <end position="25"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF84923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="222" mass="23756" checksum="48D15292296A7A38" modified="2014-10-29" version="1">MSSNTATAKRIPRVGIGGPVGSGKTMLIEMVVPILASKGYKAGIISNDVISREDADRMRKNLATRQHLMPEELVIGLATGGCPHTAVREDPSMNISVVEEMESKHGYLDLILIESGGDNITTTFSPALADYFIYIIDVSGGDKYPRKRGLGIETCDLLVINKIDLAPYVGADLAVMEGDAKAIRGGKPYVFVNCKSGQGVQQVADHIIRDVLFESPPKAAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MV12</accession>
    <name>A0A075MV12_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type multidrug transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_01056</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699954.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MV12"/>
    <dbReference type="STRING" id="1459636.NTE_01056"/>
    <dbReference type="GeneID" id="41596878"/>
    <dbReference type="KEGG" id="nev:NTE_01056"/>
    <dbReference type="eggNOG" id="arCOG00196">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_2"/>
    <dbReference type="OrthoDB" id="31298at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050763">
        <property type="entry name" value="ABC_transporter_ATP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42711">
        <property type="entry name" value="ABC TRANSPORTER ATP-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42711:SF18">
        <property type="entry name" value="ABC TRANSPORTER, ATP-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="10"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF83129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="322" mass="35461" checksum="F7A2670D0292F04E" modified="2014-10-29" version="1">MEDNDNNSCISVSQLRMNYGSVRAVDGVSFDVGYGRVFGFLGPNGAGKTTTIKVLTTLVHPTSGDVRIFGKDVVKHAKEIRKRIGVVLQEPSFEGNVTVEKSLDLYGMMWGVPGEKRRDRVRELLEQFDLLEIRGTKNDELSIGQRRRVQVAREFMHDMDLLFLDEPTVGLDPAARRTLLDYVKKHVHGGLTVFFTTHIMEEVEYLCDEIAIINRGRMIAIDTPAGLKQKYGGIKAVEIKLKDATAQSVMGLLSPIAGGQSVIEVPAQDTIRISSKDAQDVLVRAIEALARNGIQMESVSVNPPTLEEVFLTVVSSSAKSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MV17</accession>
    <name>A0A075MV17_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA 2',3'-cyclic phosphodiesterase</fullName>
            <shortName evidence="2">RNA 2',3'-CPDase</shortName>
            <ecNumber evidence="2">3.1.4.58</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_03045</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + H2O = a 3'-end 2'-phospho-ribonucleotide-RNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11828"/>
            <dbReference type="Rhea" id="RHEA-COMP:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:17353"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:83064"/>
            <dbReference type="ChEBI" id="CHEBI:173113"/>
            <dbReference type="EC" id="3.1.4.58"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 2H phosphoesterase superfamily. ThpR family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.58" evidence="2"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385595.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MV17"/>
    <dbReference type="STRING" id="1459636.NTE_03045"/>
    <dbReference type="GeneID" id="41598713"/>
    <dbReference type="KEGG" id="nev:NTE_03045"/>
    <dbReference type="eggNOG" id="arCOG01736">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081251_3_4_2"/>
    <dbReference type="OrthoDB" id="44091at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004113">
        <property type="term" value="F:2',3'-cyclic-nucleotide 3'-phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008664">
        <property type="term" value="F:RNA 2',3'-cyclic 3'-phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01940">
        <property type="entry name" value="RNA_CPDase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014051">
        <property type="entry name" value="Phosphoesterase_HXTX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004175">
        <property type="entry name" value="RNA_CPDase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02258">
        <property type="entry name" value="2_5_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35561">
        <property type="entry name" value="RNA 2',3'-CYCLIC PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35561:SF1">
        <property type="entry name" value="RNA 2',3'-CYCLIC PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02834">
        <property type="entry name" value="LigT_PEase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="LigT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoesterase HXTX" evidence="3">
        <location>
            <begin position="13"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoesterase HXTX" evidence="3">
        <location>
            <begin position="92"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="HXTX 1" evidence="2">
        <location>
            <begin position="41"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="HXTX 2" evidence="2">
        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF85080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="185" mass="20171" checksum="BABE42FF6D2820C7" modified="2014-10-29" version="1">MRAFVAVDAPGTEIAELQQEMMSFSGWSAREVKPVEQNNFHFTLIFLGEITGQQAEKVKEKLAKVRFEPFPITYTGVGAFPKASNARIVWVGLDPEGSAMLQELAGQVVAKTAEAGFVPDKPFSPHLTIFRAKNRHVAVDTAKYAGKTFGTSIVDRVYLKKSELAPSGPTYSNIYTVSAAEEKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MV18</accession>
    <name>A0A075MV18_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03473</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MV18"/>
    <dbReference type="KEGG" id="nev:NTE_03473"/>
    <dbReference type="HOGENOM" id="CLU_3162931_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="47" mass="5886" checksum="E534B00ACC4E9684" modified="2014-10-29" version="1">MYYFCTSQNFLIRSDIDVKIMLYSVMEYLHYRLSKMLIRRFYNKFSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MV65</accession>
    <name>A0A075MV65_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02498</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701102.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MV65"/>
    <dbReference type="GeneID" id="41598202"/>
    <dbReference type="KEGG" id="nev:NTE_02498"/>
    <dbReference type="HOGENOM" id="CLU_2949092_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="59" mass="6972" checksum="45A16D6DB9E5F17A" modified="2014-10-29" version="1">MTSATIDSRRKKDLYERLRSLGVNVSAVEKCDLSYDELSDLTDRLEKLVNSRKQPRWER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MV90</accession>
    <name>A0A075MV90_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02523</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MV90"/>
    <dbReference type="KEGG" id="nev:NTE_02523"/>
    <dbReference type="HOGENOM" id="CLU_2730145_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="71" mass="8013" checksum="0AB8F4A9913CA8E8" modified="2014-10-29" version="1">MNHVAPNCGDSRMSTCEKCTCKTATSLIEYEEGGKRAFQYNGKLFCQECYLEILRINESRPAEMLLLQASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVC7</accession>
    <name>A0A075MVC7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03084</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701570.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVC7"/>
    <dbReference type="STRING" id="1459636.NTE_03084"/>
    <dbReference type="GeneID" id="41598746"/>
    <dbReference type="KEGG" id="nev:NTE_03084"/>
    <dbReference type="HOGENOM" id="CLU_1782548_0_0_2"/>
    <dbReference type="OrthoDB" id="381634at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="152" mass="16410" checksum="9F94BF505B050042" modified="2014-10-29" version="1">MIHKKMMVMVSSFVIVSVVCVSSLLLSSSPFAALTPVSGEEGQASKSSASSSGNKTVTVAPGAASEELKFFDKHDPQHKWNETALSYFDSEGTELPCDKVYNGTIYYQINESLFKCDDFGHFIVSDEQALMSTMKGQDGEDGEDGEDGEDGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MW08</accession>
    <name>A0A075MW08_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Tryptophan--tRNA ligase</fullName>
            <ecNumber evidence="2 9">6.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NTE_01420</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="2 9"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700245.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MW08"/>
    <dbReference type="STRING" id="1459636.NTE_01420"/>
    <dbReference type="GeneID" id="41597214"/>
    <dbReference type="KEGG" id="nev:NTE_01420"/>
    <dbReference type="eggNOG" id="arCOG01887">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032621_0_1_2"/>
    <dbReference type="OrthoDB" id="371821at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000207">
        <property type="entry name" value="Tryptophan--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008927">
        <property type="entry name" value="PRK12285.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10055:SF1">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10055">
        <property type="entry name" value="TRYPTOPHANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="NCBIfam" id="TIGR00233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIF83484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="391" mass="44559" checksum="4831C496F8BF0F7B" modified="2014-10-29" version="1">MSSPADDGAAEKSNNNNNDFTVTPWEVEGEVDYNRLIEKFGTQPITQELLQKIKSMTGEVHPMLKLGYFFSHRDFDWILDKKQKGENFYLYTGRGPSGMVHMGHLMPWMFTKYLQDKFDSKLLFQLTDDEKFLYGQDRTREETKRYTYENILDIIAIGFDPKKTKIIVDTKHIEHLYPIATEVAKRITFSTAKAVFGFTNSTNIGMIGFPPIQAAPCFLPSIIEGKNTPVLIPAAIDQDPYWRMTRDVADRMGYYKPAQVHSKFLPGLGMMGKMSSSKPETAIFTTDEPEVVEKKVSSAFTGGQPTIALQRQLGANALGCPVFWYLRYFFDTEKQSDERMLKCKSGNLLCGECKADLAKGAKPFVVEFKKRREKAKDVVAKFMYDEKPIEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MW12</accession>
    <name>A0A075MW12_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03309</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_264357922.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MW12"/>
    <dbReference type="GeneID" id="75933639"/>
    <dbReference type="KEGG" id="nev:NTE_03309"/>
    <dbReference type="HOGENOM" id="CLU_3282993_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="40" mass="4948" checksum="24C0854090FA3672" modified="2014-10-29" version="1">MCDYMYYEELRKHKIRKQIPKPEPELEPMEKEEKPIVVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MW60</accession>
    <name>A0A075MW60_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01465</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700286.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MW60"/>
    <dbReference type="GeneID" id="41597258"/>
    <dbReference type="KEGG" id="nev:NTE_01465"/>
    <dbReference type="HOGENOM" id="CLU_2165350_0_0_2"/>
    <dbReference type="OrthoDB" id="11641at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="111" mass="12062" checksum="DFB33D112D8046C9" modified="2014-10-29" version="1">MPDWKDLTVVLCAGLIVLGAVALATSAQSSAIVKGQIVEKGIGVLRFGEKRNLTNTISVLIEDDDRVFDIKRGTVVKYPVSERDAKDLQIGSRVEMLISSYSPTVRILSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MW82</accession>
    <name>A0A075MW82_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-directed RNA polymerase subunit Rpo12</fullName>
            <ecNumber evidence="8">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">DNA-directed RNA polymerase subunit P</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rpo12</name>
        <name evidence="8" type="synonym">rpoP</name>
        <name evidence="9" type="ORF">NTE_02864</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of the RNA polymerase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="8"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701397.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MW82"/>
    <dbReference type="STRING" id="1459636.NTE_02864"/>
    <dbReference type="GeneID" id="41598546"/>
    <dbReference type="KEGG" id="nev:NTE_02864"/>
    <dbReference type="eggNOG" id="arCOG04341">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_179456_2_0_2"/>
    <dbReference type="OrthoDB" id="129238at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.30">
        <property type="entry name" value="RNA polymerase ii, chain L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00615">
        <property type="entry name" value="RNApol_arch_Rpo12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006591">
        <property type="entry name" value="RNAP_P/RPABC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029040">
        <property type="entry name" value="RPABC4/Spt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023464">
        <property type="entry name" value="Rpo12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00659">
        <property type="entry name" value="RPOLCX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63393">
        <property type="entry name" value="RNA polymerase subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 8 9" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8 9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 8 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 8" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF84902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="54" mass="6003" checksum="D88C224F6F506E44" modified="2014-10-29" version="1">MSSEGTGSVTYECMRCGTPVTVEELSRLPEIKCICGFRVFRKARPPIVKQLKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWC9</accession>
    <name>A0A075MWC9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">histidinol-phosphate transaminase</fullName>
            <ecNumber evidence="4">2.6.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">NTE_03527</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23744"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="2.6.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.9" evidence="4"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701931.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWC9"/>
    <dbReference type="STRING" id="1459636.NTE_03527"/>
    <dbReference type="GeneID" id="41599147"/>
    <dbReference type="KEGG" id="nev:NTE_03527"/>
    <dbReference type="eggNOG" id="arCOG04273">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_450274_0_0_2"/>
    <dbReference type="OrthoDB" id="33635at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004400">
        <property type="term" value="F:histidinol-phosphate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050106">
        <property type="entry name" value="HistidinolP_aminotransfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43643:SF6">
        <property type="entry name" value="HISTIDINOL-PHOSPHATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43643">
        <property type="entry name" value="HISTIDINOL-PHOSPHATE AMINOTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 14" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="9" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="13">
        <location>
            <begin position="32"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="375"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="489"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="375"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="489"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="503"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="523"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AIF85555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="606" mass="66283" checksum="88A9A06B96546437" modified="2014-10-29" version="1">MFAIKVVIDMIDSQVEIIKSRSEKGGFPQGGINLALCENPLLPLREAIEAARNEMPLSNHYTEPHSSKLRDAISRHVDAPCENIHINAGSELILKQLFTLYGRKVHLISPTYYLFEEIAESKTHTILEEKDDFLFDMSELVIPEDTTLAVVVNANNPTGGIFDINKNTSIIERHPKTMFLIDEAIIEFGGKPATELVSKYKNVVVTRTFSKAFSLAGCRVGYALANKELAGYLNNHNDAYPLARPSEAAAIASIHHFDKISERVDTLREMAKDLALQLKNLGIRVFPSETYFFLIKLPYKDVNADQFSEKLCYKNIHVRPLHLEGLENRFVRFATSTAENMTFQFTFNSAGTYPYYCILHPNMVGTVIVDGATQSSGAQQTQSPVPATTMTQQHEHQQQQQQQAHASQNTLSHSMIKAEGVSMVENVKISGILITGEKEVSVSLVYSGNVTNATTSSSSTPSVTVVAFTNHENMKRTMMGMDMMGGDGRGAEMSRDDSMGSMSAGGGSGHGGGMAGGSGMGQHGMSQGTMTMMRGSSSSNNNTQSSMNMTMMNHENTTTAMQRSQTGSTFVEGGWKSGVAVKVKLDGDSSAFEAQDIHVMVFPHIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWG8</accession>
    <name>A0A075MWG8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02962</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWG8"/>
    <dbReference type="KEGG" id="nev:NTE_02962"/>
    <dbReference type="HOGENOM" id="CLU_2662141_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="75" mass="8077" checksum="EC366C1A328B9FC2" modified="2014-10-29" version="1">MIIVGIILVVVSKVLILKSLFDQSAYESCIANNHGNAALCASAPFPFFIYGWILTAAGAAVLIYGLKYVSLKDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWI3</accession>
    <name>A0A075MWI3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hydrolase or acyltransferase of alpha/beta superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987224.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWI3"/>
    <dbReference type="STRING" id="1459636.NTE_01571"/>
    <dbReference type="GeneID" id="41597351"/>
    <dbReference type="KEGG" id="nev:NTE_01571"/>
    <dbReference type="eggNOG" id="arCOG01653">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_13_2_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46438">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46438:SF11">
        <property type="entry name" value="LIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="28"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="270" mass="30412" checksum="E86E9811828DB172" modified="2014-10-29" version="1">MPQRMTKVNGHTTRYLDYGSPVKGAKDLVLLHGLGASSERWLLVAPTLSKYFRVIVPDVVGFGYSDKPTVEYTMDFFIDFFDGFLQNLGIEKPHLVGSSFGGHLAAEYAIRNKRRIDKMALVSPAGAMRTSTPILDQYIMAALYPTFENALKAFSDMAHDPSIVTEEMVVDFVKRMNLPNAKYAFMSTLLGMRYSLPLRGRLSSVIAPTLIMWGDEDRMIPVQYAKDFREVPNSELVVIKDCGHTPYVEKPMTFNRIILKFLAGKEELVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MX38</accession>
    <name>A0A075MX38_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative flavin-nucleotide-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_03175</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701643.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MX38"/>
    <dbReference type="STRING" id="1459636.NTE_03175"/>
    <dbReference type="GeneID" id="41598833"/>
    <dbReference type="KEGG" id="nev:NTE_03175"/>
    <dbReference type="eggNOG" id="arCOG00516">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123922_5_1_2"/>
    <dbReference type="OrthoDB" id="139492at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070967">
        <property type="term" value="F:coenzyme F420 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052019">
        <property type="entry name" value="F420H2_bilvrd_red/Heme_oxyg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35176">
        <property type="entry name" value="HEME OXYGENASE HI_0854-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35176:SF6">
        <property type="entry name" value="HEME OXYGENASE HI_0854-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="PNPOx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine 5'-phosphate oxidase N-terminal" evidence="2">
        <location>
            <begin position="16"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF85207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="150" mass="16939" checksum="A45B361671ADC944" modified="2014-10-29" version="1">MEYRLADNYAKPMQEGEVAKLLNQPGILRIAMIDARDGTPLVHPVWYYYENEKFFLTVAAGGPKARSLKKNPNVYFLVDVADNSQQPYGVRGKGRVRVIDDPEYAAKVTARNVMRYMGSVDSPEAKTLVENAKSSSVIEITPLYMATWKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MX73</accession>
    <name>A0A075MX73_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Proteasome endopeptidase complex, archaeal, alpha subunit</fullName>
            <ecNumber evidence="6">3.4.25.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NTE_01839</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EC" id="3.4.25.1" evidence="6"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700587.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MX73"/>
    <dbReference type="STRING" id="1459636.NTE_01839"/>
    <dbReference type="GeneID" id="41597603"/>
    <dbReference type="KEGG" id="nev:NTE_01839"/>
    <dbReference type="eggNOG" id="arCOG00971">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035750_4_1_2"/>
    <dbReference type="OrthoDB" id="9421at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01911">
        <property type="entry name" value="proteasome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000004">
        <property type="entry name" value="Proteasome subunit alpha type-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019982">
        <property type="entry name" value="Proteasome_asu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03633">
        <property type="entry name" value="arc_protsome_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="5">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF83899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="245" mass="26711" checksum="5739F10B35EFE78D" modified="2014-10-29" version="1">MLPAAAGYDRAITVFSPDGRLYQVEYAIETVRRGTLAIGIKAKDGVVLAVEEKTRKLQINNVTQKIFQVDDHIGVAAAGYIPDARTQVDHARFFAQSNRLIYDEPVDVEGVAKNIADMAQQFTQYAGVRPFGVALLLAGVDKNGANLFLTDPSGTYIGYDAMAIGAGSDQVTDFLEKSYKQDISLAEAASLAVECIYLVSEDKSSTKHLKMAIIDTKTKTMRKIEDEELEKYAASAKERAGKHPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MX96</accession>
    <name>A0A075MX96_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01864</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700607.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MX96"/>
    <dbReference type="GeneID" id="41597626"/>
    <dbReference type="KEGG" id="nev:NTE_01864"/>
    <dbReference type="eggNOG" id="arCOG08805">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100103_1_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="201" mass="22796" checksum="90844A0C62A46CBB" modified="2014-10-29" version="1">MAGSSNNSKEKTETITFRLKAELIDQLKKETIEEGMNLNSLVQKALMEYLWCHSGVAKGTMVPTSKSRFKAIMEELSKEQILRVSEANDKTNPKSLQFVLHGEYTEQALSESLEIWSIASRFDFVKRILDDKRVYMSVRHGMGYKCSLFFCTTIVEAIHNASGRRPLATVSEDYFALTVDPTAAKHVLQSPELQRKKIKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MXE8</accession>
    <name>A0A075MXE8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">CTP synthase</fullName>
            <ecNumber evidence="11">6.3.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Cytidine 5'-triphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Cytidine triphosphate synthetase</fullName>
            <shortName evidence="11">CTP synthetase</shortName>
            <shortName evidence="11">CTPS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">UTP--ammonia ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">pyrG</name>
        <name evidence="14" type="ORF">NTE_01920</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>UTP + L-glutamine + ATP + H2O = CTP + L-glutamate + ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>UTP + NH4(+) + ATP = CTP + ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16597"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="11">Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homotetramer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="11">CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the CTP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="11"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226986923.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
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    <dbReference type="AlphaFoldDB" id="A0A075MXE8"/>
    <dbReference type="STRING" id="1459636.NTE_01920"/>
    <dbReference type="GeneID" id="41597668"/>
    <dbReference type="KEGG" id="nev:NTE_01920"/>
    <dbReference type="eggNOG" id="arCOG00063">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011675_5_0_2"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097268">
        <property type="term" value="C:cytoophidium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019856">
        <property type="term" value="P:pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03113">
        <property type="entry name" value="CTPS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01746">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000009">
        <property type="entry name" value="CTP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000002">
        <property type="entry name" value="CTP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01227">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017456">
        <property type="entry name" value="CTP_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033828">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003792">
        <property type="entry name" value="PRK05380.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00337">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="CTP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550:SF0">
        <property type="entry name" value="CTP SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06418">
        <property type="entry name" value="CTP_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3 11 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTP synthase N-terminal" evidence="13">
        <location>
            <begin position="21"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase" evidence="12">
        <location>
            <begin position="320"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Amidoligase domain" evidence="11">
        <location>
            <begin position="1"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for glutamine hydrolysis" evidence="11">
        <location>
            <position position="401"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="527"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="529"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <note>allosteric inhibitor</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="32"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="166"/>
            <end position="168"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <note>allosteric inhibitor</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="206"/>
            <end position="211"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <note>allosteric inhibitor</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="206"/>
            <end position="211"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
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        </ligand>
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        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>UTP</name>
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        </ligand>
    </feature>
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        <location>
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        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="374"/>
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        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="402"/>
            <end position="405"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="425"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="482"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF06418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AIF83979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
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        </source>
    </evidence>
    <sequence length="551" mass="60578" checksum="30DDE4E8403EFF5F" modified="2014-10-29" version="1">MQSSTLPPQQQKNNGRSSSSKFIFVIGGVMSGLGKGVTTSSTARLLQLAGYKVSCVKIDPYVNYDAGTMNPVAHGEVFVTDDGGECDMDIGNYERFIDTSMTKDHNITTGRIYMDVIAAEREGKYLGQCVQIIPHVTDAIKANLRRIAEKEKLDIMVVECGGTVGDIESLPFLEAFRQMALEVGRQNTLFIHVTLAPVLDVVGEQKTKPTQHSVQELRRIGIQPDIIAVRCKTPLTPDARRKISLFASVEQQNVISCHDAPSIYKVPEVIESQGMLKVVSQGLSLKRSKPKWGDWKKVASSFSNYDGSVRIAVVGKYVTLPDSYVSVYHALSHAGAGIGKKVEIDWIDSEKFENGGEKKIASLKEYQGVLAPGGFGKRGSEGIISAANFARENNIPYLGICFGFQLAIVAFARHVCGMAGANSTELDPHTKNPVVDFMPEQRNVHDMGGTMRLGGHNIAVAPKTLAHRLYGATTIRRRHRHRYEFNQNYLDAVTKAGLVLSAHSDSGRRMEILEIPDHKFYFAVQYHAEFSSRPGKPEQAFDAFVKAAARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MXV7</accession>
    <name>A0A075MXV7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Plastocyanin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NTE_02068</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MXV7"/>
    <dbReference type="STRING" id="1459636.NTE_02068"/>
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    <dbReference type="KEGG" id="nev:NTE_02068"/>
    <dbReference type="eggNOG" id="arCOG02926">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1709035_0_0_2"/>
    <dbReference type="OrthoDB" id="11836at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000923">
        <property type="entry name" value="BlueCu_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028871">
        <property type="entry name" value="BlueCu_1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052721">
        <property type="entry name" value="ET_Amicyanin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36507">
        <property type="entry name" value="BLL1555 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36507:SF1">
        <property type="entry name" value="BLL1555 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00127">
        <property type="entry name" value="Copper-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00196">
        <property type="entry name" value="COPPER_BLUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="Blue (type 1) copper" evidence="6">
        <location>
            <begin position="67"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF84124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="159" mass="17691" checksum="923892F8F55FEBAA" modified="2014-10-29" version="1">MVLLKKNQKTAAGISVMTFLVAVAISLVYYQFYYVPTINRKPRVPQDILNPPSITNVGILPGSSLESQAQNFFPSDVRVSLGANNKVIWKNNDNTYHSVTSDNDYVDKISGKFDSTATIGLMPSGQTYNFTFTEAGVYHYHCIPHPWMKGTVTVLAEHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MY89</accession>
    <name>A0A075MY89_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein, putative amidase</fullName>
            <ecNumber evidence="5">3.5.2.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_02160</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="3.5.2.10" evidence="5"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700829.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MY89"/>
    <dbReference type="STRING" id="1459636.NTE_02160"/>
    <dbReference type="GeneID" id="41597884"/>
    <dbReference type="KEGG" id="nev:NTE_02160"/>
    <dbReference type="eggNOG" id="arCOG04536">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055029_2_1_2"/>
    <dbReference type="OrthoDB" id="46121at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047789">
        <property type="term" value="F:creatininase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10310">
        <property type="entry name" value="Creatininase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024087">
        <property type="entry name" value="Creatininase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003785">
        <property type="entry name" value="Creatininase/forma_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35005:SF1">
        <property type="entry name" value="2-AMINO-5-FORMYLAMINO-6-RIBOSYLAMINOPYRIMIDIN-4(3H)-ONE 5'-MONOPHOSPHATE DEFORMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35005">
        <property type="entry name" value="3-DEHYDRO-SCYLLO-INOSOSE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02633">
        <property type="entry name" value="Creatininase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102215">
        <property type="entry name" value="Creatininase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF84214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="238" mass="25264" checksum="06012D1D622CB04D" modified="2014-10-29" version="1">MSSVFGMSDPEFWSALKKTKRAIIPIGSMEQHGPHLPVSTDALIAEHVSKLVAQKVGAFVLPAIAYGVSFEHDPMFHVSLRNSTLSALVCDACAALASHGVKEIIVINGHHGNIGALQYIAQDLAGRISNDVSVHVLHYWHQMKNDELGHAGEVETSLVLAIAPELVKMEKAQAGAKNPTAKSKAAYASITNSPGSFVKITGNGVWGDPKKASAEMGQRLLKEIVAGLAKTISELGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MYC7</accession>
    <name>A0A075MYC7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Arginase family hydrolase, arginase/agmainase/formiminoglutamate hydrolase</fullName>
            <ecNumber evidence="6">3.5.3.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NTE_02210</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="4">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the arginase family. Agmatinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.11" evidence="6"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MYC7"/>
    <dbReference type="STRING" id="1459636.NTE_02210"/>
    <dbReference type="KEGG" id="nev:NTE_02210"/>
    <dbReference type="eggNOG" id="arCOG01700">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039478_0_2_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008783">
        <property type="term" value="F:agmatinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033389">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via agmatine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="ARGINASE/AGMATINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358:SF26">
        <property type="entry name" value="GUANIDINO ACID HYDROLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036979">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR036979-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF84264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="286" mass="30498" checksum="B20BE4001FFA2DB8" modified="2014-10-29" version="1">MARFHRANAKSFGDANIVVMGVPDESRSHAMRRGTSTAPDTIRAASDESEFFVRDGRLIPTVPMRGTLGDKRIFDAGNVQRNSVYEQARKIVEAGKIPVTLGGDHSLTTDILKAVAGGGRKVALLYFDAHPDFVSSARNYYGSVLTDSANCVDYKKSMLVGTRAAEPEEIENAKKAGLAMVTPIDITDLGVHKVAQMIREKVAGSRVYISIDLDCVDPAFAPGVSVPSPGGVTIADLLYLLTGTISNCDVAGFDIVELSPDYDADGLTANLAARILTECIACLKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MYQ3</accession>
    <name>A0A075MYQ3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02342</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700975.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MYQ3"/>
    <dbReference type="STRING" id="1459636.NTE_02342"/>
    <dbReference type="GeneID" id="41598058"/>
    <dbReference type="KEGG" id="nev:NTE_02342"/>
    <dbReference type="HOGENOM" id="CLU_178221_0_0_2"/>
    <dbReference type="OrthoDB" id="376820at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="77" mass="8801" checksum="92F66ED259E0FE78" modified="2014-10-29" version="1">MRKSASRGILYLVAYCILGFYTFFTAMYHMADLAARLGLDTQSNPVAFVALKFRASMDCRDYVAQTSDESCYLKWHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MYZ5</accession>
    <name>A0A075MYZ5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02429</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385458.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MYZ5"/>
    <dbReference type="STRING" id="1459636.NTE_02429"/>
    <dbReference type="GeneID" id="43502645"/>
    <dbReference type="KEGG" id="nev:NTE_02429"/>
    <dbReference type="HOGENOM" id="CLU_3021099_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="55" mass="5955" checksum="2F482444CB870765" modified="2014-10-29" version="1">MVQRRILKNQRRVGEAVMIVSGIGVGILGLALSIPQISFGGLCIIGLGIFSIFWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MZ06</accession>
    <name>A0A075MZ06_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MZ06"/>
    <dbReference type="STRING" id="1459636.NTE_02439"/>
    <dbReference type="KEGG" id="nev:NTE_02439"/>
    <dbReference type="eggNOG" id="arCOG01055">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_159725_0_1_2"/>
    <dbReference type="OrthoDB" id="140255at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038723">
        <property type="entry name" value="ArnR1-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14947">
        <property type="entry name" value="HTH_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ArnR1-like winged helix-turn-helix" evidence="1">
        <location>
            <begin position="31"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="129" mass="14895" checksum="8F57D4D4ABA6C327" modified="2014-10-29" version="1">MTLIEMYDCSFVRGFLYKREVYTPLKRSANRSRVEIAYDILKLCLTPQKKTQIMYRANLSYEQANYYLAVFVTKGLLEQNMRQGVNDQGYRQYLITTQKGRDVLQGLANAIELLDSIFATTTTKIQASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MZN3</accession>
    <name>A0A075MZN3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02656</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701224.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MZN3"/>
    <dbReference type="STRING" id="1459636.NTE_02656"/>
    <dbReference type="GeneID" id="41598348"/>
    <dbReference type="KEGG" id="nev:NTE_02656"/>
    <dbReference type="eggNOG" id="arCOG08761">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2165142_0_0_2"/>
    <dbReference type="OrthoDB" id="6976at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="110" mass="12735" checksum="2830BE69F36F2ADE" modified="2014-10-29" version="1">MMTSKYAGFPVIDTIDLRDAADIRLAVDKVADAYEKRQDEFSFRILLPRGEKLTGKAKKLGMTFQGEFILTIRKRGLVPQVRDLRYVHDEEHYGWLLASPKIFEKFEGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MZZ8</accession>
    <name>A0A075MZZ8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cysteine desulfurase</fullName>
            <ecNumber evidence="3">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NTE_02778</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SR1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="3"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701328.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MZZ8"/>
    <dbReference type="STRING" id="1459636.NTE_02778"/>
    <dbReference type="GeneID" id="41598467"/>
    <dbReference type="KEGG" id="nev:NTE_02778"/>
    <dbReference type="eggNOG" id="arCOG00066">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003433_0_0_2"/>
    <dbReference type="OrthoDB" id="9577at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000003">
        <property type="entry name" value="Cysteine desulfurase IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016454">
        <property type="entry name" value="Cysteine_dSase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002806">
        <property type="entry name" value="PRK02948.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601:SF34">
        <property type="entry name" value="CYSTEINE DESULFURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601">
        <property type="entry name" value="CYSTEINE DESULFURYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005572">
        <property type="entry name" value="NifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="10">
        <location>
            <begin position="4"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIF84819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="391" mass="42286" checksum="B08918B4B397A192" modified="2014-10-29" version="1">MERIYLDSAASTPVADEVIQEMIPYLKQQFGNPSSIHYFGRETTRAIQLARKRVADLVSAKPQEITFTSGGTEADNLAVKGTADYAKSKDPSKNHIITSYIEHDAVLEPCRDLERLGYNVTFLPVTPEGLVRPEVLKEAITPSTALVSIMHANNEVGTIQPIKELAKIAHDAGALFHTDAVQAAGKIPVDVKDLGVDLLSMSSHKINGPKGVGALYIRDGLEIMPIIHGGGQESAMRSGTENVPGIVGFGKACELAKGRLAEYQRQVSALRDCLIENVLSEIPHSRLNGSRTSRLAANAHFTFFGVNGEDLIIKLDEEGIAASTGSACSVKKQKPSHVLKAMGFSYEEITGSLRISLSMQNTKEEMDRTVSALAGVVKELRSLSPFKSKYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N0C5</accession>
    <name>A0A075N0C5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ParB-like partition protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_02906</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701430.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N0C5"/>
    <dbReference type="STRING" id="1459636.NTE_02906"/>
    <dbReference type="GeneID" id="41598584"/>
    <dbReference type="KEGG" id="nev:NTE_02906"/>
    <dbReference type="eggNOG" id="arCOG11113">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1100917_0_0_2"/>
    <dbReference type="OrthoDB" id="8181at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2830">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1530.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050336">
        <property type="entry name" value="Chromosome_partition/occlusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041468">
        <property type="entry name" value="HTH_ParB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004437">
        <property type="entry name" value="ParB/RepB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00180">
        <property type="entry name" value="parB_part"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33375">
        <property type="entry name" value="CHROMOSOME-PARTITIONING PROTEIN PARB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33375:SF1">
        <property type="entry name" value="CHROMOSOME-PARTITIONING PROTEIN PARB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17762">
        <property type="entry name" value="HTH_ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109709">
        <property type="entry name" value="KorB DNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="ParB/Sulfiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB-like N-terminal" evidence="2">
        <location>
            <begin position="4"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF84944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="252" mass="28403" checksum="9B5ECF9A365A02D2" modified="2014-10-29" version="1">MQVKNIPVNMIDIAEENVRKDHSFGEDDKDRLIKEHLSKFDLLQPVVVRFDDKSRRYKLLIGRRRFFALSAKGETQIPAVVTELEGAEAEAASLFENLIRKDLSPLEKARMVKRLVDTTKAGITGVAAKYGLPKSTVSEWLSILSLPQVLQDNIEQGRITSYEAIRIARKPKTVQEKLVAAAQEGRLQEEMAQAGVKRGAPRGLLTIRIVFDPRRKSDKQLWEKLNAKAEESGLDVTDYARSILSGHVQRDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N0X3</accession>
    <name>A0A075N0X3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF167 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0235 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385605.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N0X3"/>
    <dbReference type="STRING" id="1459636.NTE_03100"/>
    <dbReference type="GeneID" id="41598761"/>
    <dbReference type="KEGG" id="nev:NTE_03100"/>
    <dbReference type="eggNOG" id="arCOG04058">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130694_5_3_2"/>
    <dbReference type="OrthoDB" id="10336at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1200.10">
        <property type="entry name" value="YggU-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003746">
        <property type="entry name" value="DUF167"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036591">
        <property type="entry name" value="YggU-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00251">
        <property type="entry name" value="DUF167 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02594">
        <property type="entry name" value="DUF167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01152">
        <property type="entry name" value="DUF167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69786">
        <property type="entry name" value="YggU-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="72" mass="8081" checksum="B148B9C9CE60A613" modified="2014-10-29" version="1">MKKYRVTVRFSADGRLEVAGDEITVSIKSQPERGRANRELVRRLAEHFGVSEQDVRILSGLASRKKIVEVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N0Z0</accession>
    <name>A0A075N0Z0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Probable cobyric acid synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">cobQ</name>
        <name evidence="9" type="ORF">NTE_03115</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the CobB/CobQ family. CobQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701594.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N0Z0"/>
    <dbReference type="STRING" id="1459636.NTE_03115"/>
    <dbReference type="GeneID" id="41598775"/>
    <dbReference type="KEGG" id="nev:NTE_03115"/>
    <dbReference type="eggNOG" id="arCOG00105">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019250_0_0_2"/>
    <dbReference type="OrthoDB" id="53136at2157"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015420">
        <property type="term" value="F:ABC-type vitamin B12 transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00028">
        <property type="entry name" value="CobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004459">
        <property type="entry name" value="CobQ_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001989">
        <property type="entry name" value="PRK00784.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21343:SF1">
        <property type="entry name" value="COBYRIC ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21343">
        <property type="entry name" value="DETHIOBIOTIN SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="9" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobQ/CobB/MinD/ParA nucleotide binding" evidence="8">
        <location>
            <begin position="8"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF85149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="283" mass="31217" checksum="9C2CC204CC03E70C" modified="2014-10-29" version="1">MARRAKLLMVQGTSSGAGKSTLVAGLCRMYADRNYRVVPFKSQNMSSKLYLTKEGAKMAQAQAVQAVASKKQPDPRMNPILLKPLGEYRSEVIINGRFYSEMHARDYYEKFALKQGLPLALKALDGLRRENDLVIIEGAGSPAEINIAKYDIANMLLAEEVGAPVVIVADIERGGCFASMVGTLQLLKTRHRALVKGFLINKFRGDRSLLEPAITETQKLTKKRILGVIPKIDFDLPEEDSLVGSATVRTDLPQDAWDWQIGMLAKAIKDSIDVKRLDGIVGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N150</accession>
    <name>A0A075N150_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PhnB-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N150"/>
    <dbReference type="KEGG" id="nev:NTE_03172"/>
    <dbReference type="eggNOG" id="arCOG09469">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054535_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06588">
        <property type="entry name" value="PhnB_like"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009725">
        <property type="entry name" value="3_dmu_93_MTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027259">
        <property type="entry name" value="MTase_demethylubiq_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028973">
        <property type="entry name" value="PhnB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33990:SF4">
        <property type="entry name" value="PHNB-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33990">
        <property type="entry name" value="PROTEIN YJDN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06983">
        <property type="entry name" value="3-dmu-9_3-mt"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021700">
        <property type="entry name" value="3_dmu_93_MTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500687">
        <property type="entry name" value="MTase_demethylubiq_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhnB-like" evidence="1">
        <location>
            <begin position="13"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="PhnB-like" evidence="1">
        <location>
            <begin position="148"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="237" mass="26698" checksum="3FE1C250B19E252C" modified="2014-10-29" version="1">MPKKSEHLTAGEQKITPFLWFDNQAEEAAKFYTSIFKNSKIGTIAPYGEAGAQASGMPKGTVMTVTFELEGQGFIALNGGPVFKFTSAVSFFVSCNTEEEIDRLYKKLSEGGMVLMELDEYPFSKKFCWINDRFGVSWQLNLANSTQQKITPFLMFVRERNGKAEEAMNFYVSLFENSRIVKIERYGAGEEEPEGTVKHATFSLDGQDFMALDSNREHPFTFTPAISLLVPARRSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLN0</accession>
    <name>A0A075MLN0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00309</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699384.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLN0"/>
    <dbReference type="GeneID" id="41596214"/>
    <dbReference type="KEGG" id="nev:NTE_00309"/>
    <dbReference type="HOGENOM" id="CLU_196478_0_0_2"/>
    <dbReference type="OrthoDB" id="11570at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="90" mass="9957" checksum="0F8B597F6AF7AD22" modified="2014-10-29" version="1">MKTETKTITTIVRDEEKNAGTRISRHVQFTLCGSCFWCASYLDGRGVEKCPSCESGKVESLPVAGNEMYTFDYGTLRGVTVRFVPSKPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MM15</accession>
    <name>A0A075MM15_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MM15"/>
    <dbReference type="STRING" id="1459636.NTE_00086"/>
    <dbReference type="KEGG" id="nev:NTE_00086"/>
    <dbReference type="HOGENOM" id="CLU_3338258_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="37" mass="4232" checksum="FC5844709AB05555" modified="2014-10-29" version="1">MHYIHSPTASHIIIIIIIILLKKDAEHKEGNVIKDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MM24</accession>
    <name>A0A075MM24_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Response regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MM24"/>
    <dbReference type="KEGG" id="nev:NTE_00211"/>
    <dbReference type="HOGENOM" id="CLU_2353091_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="96" mass="10731" checksum="C3A525B3FB457C6F" modified="2014-10-29" version="1">MPKISGFELVRLIYGVDKNTRIILMSDSDLEREEFEKSEIASKVDAFMKKPRGIMKLISHIEALLKHKRRELAALVASAGASLMALSFEVVTAAMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MM34</accession>
    <name>A0A075MM34_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00226</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699320.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MM34"/>
    <dbReference type="STRING" id="1459636.NTE_00226"/>
    <dbReference type="GeneID" id="41596146"/>
    <dbReference type="KEGG" id="nev:NTE_00226"/>
    <dbReference type="eggNOG" id="arCOG02217">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_175270_2_0_2"/>
    <dbReference type="OrthoDB" id="45710at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039709">
        <property type="entry name" value="VapB3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42244">
        <property type="entry name" value="ANTITOXIN VAPB3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42244:SF2">
        <property type="entry name" value="ANTITOXIN VAPB3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="75" mass="8760" checksum="464A629A12ED077E" modified="2014-10-29" version="1">MASAPLSVRLPEETREKMKEIDIDWAEYIRTAIEAKIRELQRKKAADSMDKIRERTKYGEFDSTKSIREDRDAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMV7</accession>
    <name>A0A075MMV7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00408</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699450.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMV7"/>
    <dbReference type="STRING" id="1459636.NTE_00408"/>
    <dbReference type="GeneID" id="41596288"/>
    <dbReference type="KEGG" id="nev:NTE_00408"/>
    <dbReference type="eggNOG" id="arCOG08700">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2313656_0_0_2"/>
    <dbReference type="OrthoDB" id="9219at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="98" mass="10460" checksum="FEFE5BA4EF78793E" modified="2014-10-29" version="1">MSQIDSTKKVYVIVHGQRNLVEPVKEKLAAAGFKNTEMASLDKAGNAGEYVAMLWPPMAASEIMVSVITGPAEPGKSQGMGAWGSVATKEVMRLPLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMY5</accession>
    <name>A0A075MMY5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glucose/sorbosone dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00547</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMY5"/>
    <dbReference type="STRING" id="1459636.NTE_00547"/>
    <dbReference type="KEGG" id="nev:NTE_00547"/>
    <dbReference type="eggNOG" id="arCOG02796">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012253_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012938">
        <property type="entry name" value="Glc/Sorbosone_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH_b-prop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19328">
        <property type="entry name" value="HEDGEHOG-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19328:SF13">
        <property type="entry name" value="HIPL1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07995">
        <property type="entry name" value="GSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="Soluble quinoprotein glucose dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose/Sorbosone dehydrogenase" evidence="1">
        <location>
            <begin position="66"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="409" mass="44064" checksum="86ECE74C74DF824C" modified="2014-10-29" version="1">MMLLMPCTSTKAAAAVTLLVMAVVIFSVVVSPNLLSPVAAQNLSEQQQQRQEAESRLKVETVASNLHIPWSIAFASDGRIFFTERAGNVQVIEANGTLAKQPVAKIGAVAAIGEGGLLGLALDPDFEKNHFVYLYYTYSTIPFFGSANRVSKFTEKDNALVNEQILLDKIPAASNHDGGRIKFGPDGKLYVATGDAANGSSSQDLGSLAGKILRINSDGTIPADNPFSNSPVYSYGHRNPQGFDWDPSTGKLVEAEHGPSGEKGLFAHDEVNVIEPGKNYGWPNVIGKANDTRYVDPVLETGNVTWAPSGASFYHGDKIPEWKNKFLVATLRGQHLEVMQLDTSAENNKEAASSSSVVISSEAIFQNMYGRLRDVQEGPDGYVYVLTSNTDGRGSPAVDDDKILRISPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MN86</accession>
    <name>A0A075MN86_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MN86"/>
    <dbReference type="KEGG" id="nev:NTE_00180"/>
    <dbReference type="HOGENOM" id="CLU_2366063_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="95" mass="10553" checksum="75BE6297A0CF22BB" modified="2014-10-29" version="1">MINMGMTQILTVSEKLSALMIVRAIFLMGEHLCSVAARTHWLAAIHTVVPCIVVVEFYTAVGTSHFLEPTQVPLIILFVQDSWCTGTILCHLLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MND9</accession>
    <name>A0A075MND9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00240</name>
        <name evidence="2" type="ORF">NTE_03068</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699329.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MND9"/>
    <dbReference type="GeneID" id="41598732"/>
    <dbReference type="KEGG" id="nev:NTE_00240"/>
    <dbReference type="KEGG" id="nev:NTE_03068"/>
    <dbReference type="HOGENOM" id="CLU_2344901_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="102" mass="12011" checksum="1CE1942343B1DDA1" modified="2014-10-29" version="1">MTTTIVRIEHAVGNFEAWKKMFDTDPLKREKSGVRRYRILRPKDDQNYVMIDLEFDNATRAQAMAEALRKMWESSKDAQTVMQNPKVRVVEVAETNEYREDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNE3</accession>
    <name>A0A075MNE3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00594</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699598.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNE3"/>
    <dbReference type="GeneID" id="41596457"/>
    <dbReference type="KEGG" id="nev:NTE_00594"/>
    <dbReference type="eggNOG" id="arCOG08805">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100103_1_0_2"/>
    <dbReference type="OrthoDB" id="9412at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="176" mass="20643" checksum="8872911E321C5EF3" modified="2014-10-29" version="1">MTDDSKKTVTMTFRIEEGVMGKLRSESEKREVSLNTLVNQILKRFVEWDVYEPKIGMIPIARPIVHTLFENMEREEIIEMAQKVGKGVVHDIALFMKTRMDLSSFLSWLETRMKSSSIEFSHSENEGRHVFVMKHDLGYNWSLYHKTLLEQIFNEILNRRVDIVTSNTMLTLTVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNK9</accession>
    <name>A0A075MNK9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Flavin prenyltransferase UbiX</fullName>
            <ecNumber evidence="6">2.5.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ubiX</name>
        <name evidence="8" type="ORF">NTE_00635</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>dimethylallyl phosphate + FMNH2 = prenylated FMNH2 + phosphate</text>
            <dbReference type="Rhea" id="RHEA:37743"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:87467"/>
            <dbReference type="ChEBI" id="CHEBI:88052"/>
            <dbReference type="EC" id="2.5.1.129"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the UbiX/PAD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.129" evidence="6"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNK9"/>
    <dbReference type="STRING" id="1459636.NTE_00635"/>
    <dbReference type="KEGG" id="nev:NTE_00635"/>
    <dbReference type="eggNOG" id="arCOG01703">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074522_0_1_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106141">
        <property type="term" value="F:flavin prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1950:FF:000001">
        <property type="entry name" value="Flavin prenyltransferase UbiX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="entry name" value="Flavin prenyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01984">
        <property type="entry name" value="ubiX_pad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004507">
        <property type="entry name" value="UbiX-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004685">
        <property type="entry name" value="PRK06029.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00421">
        <property type="entry name" value="ubiX_pad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43374">
        <property type="entry name" value="FLAVIN PRENYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43374:SF1">
        <property type="entry name" value="FLAVIN PRENYLTRANSFERASE PAD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="Homo-oligomeric flavin-containing Cys decarboxylases, HFCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 6" id="KW-0288">FMN</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="1 6" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Flavoprotein" evidence="7">
        <location>
            <begin position="8"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="15"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="92"/>
            <end position="95"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>dimethylallyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:88052"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>dimethylallyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:88052"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00060793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF82715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="198" mass="21596" checksum="583E61CC5D7C5FF1" modified="2014-10-29" version="1">MYKLATVRLVIAITGASGVIYGIRALEALKKLKVETHLILSEWGEKTIKIETDRTGDSVRSLATKVYEDTNMAAPVSSGSFRIDGMAVIPCSMRTLASIANGLDDTLVSRAASVCIKEGRKVVIVPREAPLSKIHLENMSKLAGIHNVVIMPAMPGFYHKPQTMDDLIDHVVGKVLDQFGIDHGLFRRWGEHTGGKMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNL1</accession>
    <name>A0A075MNL1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01073</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385112.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNL1"/>
    <dbReference type="GeneID" id="43502591"/>
    <dbReference type="KEGG" id="nev:NTE_01073"/>
    <dbReference type="HOGENOM" id="CLU_3002958_0_0_2"/>
    <dbReference type="OrthoDB" id="373368at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="56" mass="6906" checksum="91DF2DD890A47C21" modified="2014-10-29" version="1">MRILRAITNAINKRLDRKGKYRNPEYDDSEIEGMMRYFKLSNYYDLLRLLKNMCRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNM8</accession>
    <name>A0A075MNM8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Vinylacetyl-CoA delta-isomerase /4-hydroxybutyryl-CoA dehydratase</fullName>
            <ecNumber evidence="6">4.2.1.120</ecNumber>
            <ecNumber evidence="6">5.3.3.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NTE_00645</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.2.1.120" evidence="6"/>
    <dbReference type="EC" id="5.3.3.3" evidence="6"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699638.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNM8"/>
    <dbReference type="STRING" id="1459636.NTE_00645"/>
    <dbReference type="GeneID" id="41596508"/>
    <dbReference type="KEGG" id="nev:NTE_00645"/>
    <dbReference type="eggNOG" id="arCOG02143">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023920_1_0_2"/>
    <dbReference type="OrthoDB" id="32865at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043721">
        <property type="term" value="F:4-hydroxybutanoyl-CoA dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050393">
        <property type="term" value="F:vinylacetyl-CoA delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3140.10">
        <property type="entry name" value="4-hydroxybutyryl-coa dehydratase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004925">
        <property type="entry name" value="HpaB/PvcC/4-BUDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024719">
        <property type="entry name" value="HpaB/PvcC/4-BUDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024674">
        <property type="entry name" value="HpaB/PvcC/4-BUDH_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36117">
        <property type="entry name" value="4-HYDROXYPHENYLACETATE 3-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36117:SF3">
        <property type="entry name" value="4-HYDROXYPHENYLACETATE 3-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03241">
        <property type="entry name" value="HpaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11794">
        <property type="entry name" value="HpaB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000331">
        <property type="entry name" value="HpaA_HpaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpaB/PvcC/4-BUDH N-terminal" evidence="5">
        <location>
            <begin position="6"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="HpaB/PvcC/4-BUDH C-terminal" evidence="4">
        <location>
            <begin position="280"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF11794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF82725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="507" mass="56434" checksum="6D11560F622522F9" modified="2014-10-29" version="1">MPIKNGAEYVESLRGRKLKVYLFGQLVKEPVDHPMIRPSINAVAATYDLANAEPEMAGAKSSISGLQVNRFLHIAESAEDLVNQNKMQRRLGQLTGTCFQRCVGMDALNSLYSTTYEIDQKHNTKYHSRLKEFIKMIQRENYVIGGAMTDVKGDRSLSPSQQPDPDMFVHIVKRDKKGVYITGAKAHQTGCINSHWILVMPTMRLKGEDKDYAIVGAVPVDAPGITYIYGRQSCDTRSMEEGDIDAGNSKFGGQEAMIIFDNVFIPNELIFMDGEYDYAAMLVERFTCYHRRSYVCKTGLGDVLIGAAAAIADYNGVASASHIKDKLVEMTHLNETIFGAGIASSYMAHQTASGNWQCDDMLANVCKHNVTKFPYEISRLAQDIAGGLMVTLPSEKDFRGPETGPLLEKYLKGRKGVSTESRVRMLRLIENMTLGRNAVGYLTESMHGAGSPQAQRIQIARQMQLEYKKKLAKNLASVKEGETAEISQENSEYFNKIFGVRKKGKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNP2</accession>
    <name>A0A075MNP2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Dolichol-phosphate mannosyltransferase</fullName>
            <ecNumber evidence="8">2.4.1.83</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Dolichol-phosphate mannose synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Dolichyl-phosphate beta-D-mannosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Mannose-P-dolichol synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">NTE_00665</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.83" evidence="8"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699654.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNP2"/>
    <dbReference type="STRING" id="1459636.NTE_00665"/>
    <dbReference type="GeneID" id="41596525"/>
    <dbReference type="KEGG" id="nev:NTE_00665"/>
    <dbReference type="eggNOG" id="arCOG00894">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039727_0_0_2"/>
    <dbReference type="OrthoDB" id="11098at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004582">
        <property type="term" value="F:dolichyl-phosphate beta-D-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06442">
        <property type="entry name" value="DPM1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000119">
        <property type="entry name" value="Dolichol-phosphate mannosyltransferase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039528">
        <property type="entry name" value="DPM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007267">
        <property type="entry name" value="GtrA_DPMS_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398:SF1">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04138">
        <property type="entry name" value="GtrA_DPMS_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 25" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16" id="KW-0464">Manganese</keyword>
    <keyword evidence="15 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 25" id="KW-0808">Transferase</keyword>
    <keyword evidence="11 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 22" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="23">
        <location>
            <begin position="11"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="GtrA/DPMS transmembrane" evidence="24">
        <location>
            <begin position="264"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00053724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00074878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00082336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00082614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00083744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF04138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="AIF82745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="389" mass="43442" checksum="38246D68EFF4B667" modified="2014-10-29" version="1">MTLQKPLLKLSLILPTYNEAENIIKILESIEDALPETMTSEVIIVDDNSPDDTGKIAEQYASQKRGNNRALSLKVIHRATKGGLSSAIVRGIHSAQGEIVVVMDSDFSHPPQIIPEMIKKLEGSPPVDIVVASRYVRGGSIIGWPFKRRLLSRGATKIAQYGLGVKKVKDPMSGYFAFRRQIVEGIEFDAIGYKILLEILVKAKNPHVKEVPYTFTNRTSGASKLNLPVIFDYVKSVWRLYRYGRSISAKEKRASVKFLSKAARFYSVGATGLLVNYASSFILSSLFPNLWYLHASAVGILLSITSNFFLNKVWTFEDRGFEIRKTAKQYGLFLGFSTFGALIQIGALYLLVETYHISYPLSLVLAVLAASSSNFLLNKKWTFNERLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNT4</accession>
    <name>A0A075MNT4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Na+/H+ antiporter NhaD-like permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NTE_00795</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CitM (TC 2.A.11) transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699756.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNT4"/>
    <dbReference type="STRING" id="1459636.NTE_00795"/>
    <dbReference type="GeneID" id="41596645"/>
    <dbReference type="KEGG" id="nev:NTE_00795"/>
    <dbReference type="eggNOG" id="arCOG00238">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011920_4_0_2"/>
    <dbReference type="OrthoDB" id="19068at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015105">
        <property type="term" value="F:arsenite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01116">
        <property type="entry name" value="P_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000802">
        <property type="entry name" value="Arsenical_pump_ArsB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051475">
        <property type="entry name" value="Diverse_Ion_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43568">
        <property type="entry name" value="P PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43568:SF1">
        <property type="entry name" value="P PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00758">
        <property type="entry name" value="ARSENICPUMP"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="273"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="411"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="455"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Citrate transporter-like" evidence="9">
        <location>
            <begin position="54"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIF82873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="480" mass="50678" checksum="A21251C92F4A70F6" modified="2014-10-29" version="1">MALLEASAAHKKKTVIGLALVATLSAIVLTVPDVLGFSISLPLKLTSIVLLSVYVVLSFEIVHRTAIALAGATAVIAIIISTGLVQAGESFEFVTEAIDFNTIGLLLGMMIIVAIMAETGVFQYLAIRMSKASKGNMWKLLVMMSVFTAVTSMFIDNVTTVLLMVPITISIFRIFRLSPVPFILAQVLASNVGGTATLIGDPPNILIGSAANIDFNAFLFHMGPTIGVSMVASLFMLKFLFRKDLAQKPQNLDELMAQDEKSLITDKGVMKKSMIVLAGVIALFVIHGSLHVEPSLIALGGAGVLLVATRAKPEKVFHDVDWATLIFFAGLFVIISGAEHAGMIDLLANTALGITGGEPTVTFFLIIWMSAVASAFVDNIPFAATMIPLIHVLNQNGSIASAFGGFEISPLWWALALGVGLGGNGTLIGSSAGVVATGLSEKGGNPITFNNFMKIGFPFMIMTVAVGSVVLFVDMMLRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNU6</accession>
    <name>A0A075MNU6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNU6"/>
    <dbReference type="KEGG" id="nev:NTE_00810"/>
    <dbReference type="eggNOG" id="arCOG08825">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1472029_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="183" mass="19939" checksum="DC9E4D39192E5C80" modified="2014-10-29" version="1">MKISQRVVANTAFALAILVLVAVPLLLQQQGHLAEAHLLGIVKQVDNYQVSFQQIPQFPSAGKNTTLHFSVLQDNAAISNVNAAVQIMEKDSGKIVEQMPYKLHEISDITIPYTFQNNTDYAVNLLMRMDDGNPEHMAKPLVADFDVSVIPTSAISPTELLMGALPFTAGLIGAVVLVFKKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNW4</accession>
    <name>A0A075MNW4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lactoylglutathione lyase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699782.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNW4"/>
    <dbReference type="GeneID" id="41596674"/>
    <dbReference type="KEGG" id="nev:NTE_00830"/>
    <dbReference type="eggNOG" id="arCOG04946">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_127592_3_0_2"/>
    <dbReference type="OrthoDB" id="134577at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07247">
        <property type="entry name" value="SgaA_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052164">
        <property type="entry name" value="Anthracycline_SecMetBiosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053863">
        <property type="entry name" value="Glyoxy/Ble-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33993">
        <property type="entry name" value="GLYOXALASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33993:SF2">
        <property type="entry name" value="VOC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22677">
        <property type="entry name" value="Ble-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyoxalase/Bleomycin resistance-like N-terminal" evidence="1">
        <location>
            <begin position="3"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="122" mass="13556" checksum="3FDD5E0F634C0C1C" modified="2014-10-29" version="1">MATIVYFEIASDNTERAGKFYGTLFGWKTEKMPGPVEYLMFSTTDQSGKEVGGGGIMKRKTPDQGIINYIGVDSVEKYAKKVQELGGKVKVPKTEVPDMGWFAVCTDTENNTFGLWESKPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MP35</accession>
    <name>A0A075MP35_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Periplasmic component of the Tol biopolymer transport system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_00481</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TolB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MP35"/>
    <dbReference type="KEGG" id="nev:NTE_00481"/>
    <dbReference type="eggNOG" id="arCOG03383">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_454650_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="WD40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36842:SF1">
        <property type="entry name" value="PROTEIN TOLB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36842">
        <property type="entry name" value="PROTEIN TOLB HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="333"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF82562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="600" mass="62732" checksum="9A15577EE4F7D348" modified="2014-10-29" version="1">MPNTGNINTSFCILLAKLLLPQRRLEWPKVMPVILLLLALLNLVAFPLLNSMTGTDLPISADLQRPQNAYAATAGTGSSSSSSASSSKSASASASATADANGRIAFGVFYGAGNIVCGGAIFIMNPDGTNPKRVPNADGCGSSPSFSPDGKRLVFDKWSTGTSGFLGGSEIDAVNLDGTDPVWFSVTNRTVWWMYDYSPSFSPDGTKIVFSSWKIDDDGHRHIYVMNSNGTVEGAVRLTNNNTADDDSPVYSPDGKKIVFTRAGDIYSMNADDGGDLTNLTNNGADANNISPTFSPNGKKIAFASDRDDEHRHDPFGSVTNNWNIYVMNASDGSNQTRLTSNPARDDGPTWSPDGAKIAFSSWRDHHGWHSEIYVMNAADGSGQKRITNFDTLPGGGDSFGPPSWGPSAGTRILSDDHDAAVVVADSLSCLALSAQQETKTTMATSATATNTTAALPPPSSAAVAWDPATSTCTINNGVTLAISKSGFLAIAPTVTLKVSMLAVLQNNGTIISSGAVKNDGTIDNLGVINSAGAIENYGLLKNSGTLSNSNTIDNYGTIDNIKGKSGRFVNSGYIIVHSTDAGGRITGSGSIVNSGYIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MP75</accession>
    <name>A0A075MP75_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative membrane protein/domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NTE_00884</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MP75"/>
    <dbReference type="STRING" id="1459636.NTE_00884"/>
    <dbReference type="KEGG" id="nev:NTE_00884"/>
    <dbReference type="eggNOG" id="arCOG03633">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104051_0_0_2"/>
    <dbReference type="OrthoDB" id="288430at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051791">
        <property type="entry name" value="Pra-immunoreactive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010432">
        <property type="entry name" value="RDD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36115">
        <property type="entry name" value="PROLINE-RICH ANTIGEN HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06271">
        <property type="entry name" value="RDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="34"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="RDD" evidence="8">
        <location>
            <begin position="28"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF82960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="203" mass="22945" checksum="BE4015AD9DFBD0FD" modified="2014-10-29" version="1">MSMNPKNQPNGAAGGDRPPTQNPEIILAKWSTRFWAWLVDFMVVNVALAVLFGLLSMPMWLYGFTNPGMIMMTRGMMTSSLPYIGGEWWWNGGFGGPFSFAISSLVFFAYWTYMESRHEGRSIGKMLLHIRTTNLEGNQADTTSIAISSFGKAFLLPIDVFFGWIFTNDKRQRLLSRAAKTIVIKTTNDDNRSTQSTAKYLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPE0</accession>
    <name>A0A075MPE0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA polymerase sliding clamp</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Proliferating cell nuclear antigen homolog</fullName>
            <shortName evidence="3">PCNA</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pcn</name>
        <name evidence="8" type="ORF">NTE_00934</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.</text>
    </comment>
    <comment type="function">
        <text evidence="5">Sliding clamp subunit. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the PCNA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699864.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPE0"/>
    <dbReference type="STRING" id="1459636.NTE_00934"/>
    <dbReference type="GeneID" id="41596769"/>
    <dbReference type="KEGG" id="nev:NTE_00934"/>
    <dbReference type="eggNOG" id="arCOG00488">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043978_1_0_2"/>
    <dbReference type="OrthoDB" id="14749at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030337">
        <property type="term" value="F:DNA polymerase processivity factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00577">
        <property type="entry name" value="PCNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00317">
        <property type="entry name" value="DNApol_clamp_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000730">
        <property type="entry name" value="Pr_cel_nuc_antig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022649">
        <property type="entry name" value="Pr_cel_nuc_antig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022648">
        <property type="entry name" value="Pr_cel_nuc_antig_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00590">
        <property type="entry name" value="pcna"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11352">
        <property type="entry name" value="PROLIFERATING CELL NUCLEAR ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11352:SF0">
        <property type="entry name" value="PROLIFERATING CELL NUCLEAR ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02747">
        <property type="entry name" value="PCNA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00705">
        <property type="entry name" value="PCNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00339">
        <property type="entry name" value="PCNACYCLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 3 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proliferating cell nuclear antigen PCNA N-terminal" evidence="6">
        <location>
            <begin position="13"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Proliferating cell nuclear antigen PCNA C-terminal" evidence="7">
        <location>
            <begin position="126"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF83010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="250" mass="27412" checksum="26E56A5E0467F742" modified="2014-10-29" version="1">MVFVAKTKSPDEWKAVASAISTLVDEATFEATAEGISFRGMDPSHIALIDIFWPAAAFEKYECDSAVKFGIRVDEFSKLVKRADKKDTVEILLSDDSMLHVRMQNGYKREYKTRLIESSASSTPLPKLNFNSKAVLSAVAFDKVLSDVQVVSEFISLESKSGRINFAGKGDSGEASVTLEAGNEGLEELAVKEDSKATYSLDYLSKITKAVIAMGGSVAAEYSSKMPLRLEFKIANVGRIHFYLAPRVQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPK8</accession>
    <name>A0A075MPK8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Tyrosyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NTE_01075</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>tRNA(Tyr) + L-tyrosine + ATP = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="1"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699968.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPK8"/>
    <dbReference type="STRING" id="1459636.NTE_01075"/>
    <dbReference type="GeneID" id="41596893"/>
    <dbReference type="KEGG" id="nev:NTE_01075"/>
    <dbReference type="eggNOG" id="arCOG01886">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035267_1_1_2"/>
    <dbReference type="OrthoDB" id="8389at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023617">
        <property type="entry name" value="Tyr-tRNA-ligase_arc/euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050489">
        <property type="entry name" value="Tyr-tRNA_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006330">
        <property type="entry name" value="PRK08560.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46264:SF4">
        <property type="entry name" value="TYROSINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46264">
        <property type="entry name" value="TYROSINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006588">
        <property type="entry name" value="TyrRS_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIF83148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="348" mass="39524" checksum="802C87C017A1FE7D" modified="2014-10-29" version="1">MDVQERIALVMREPTEEVITAGELKALFETKSKPRHYIGLEISGILHLGSLILTGFKINDFIKAGIDCTVFLADWHTYINDKLGGDWDRIRKVSEYYADAFRFFCPGVNIVTGSDLYAKTPDYWENFVRFSKHMTLARTMRSLTIMGRKETDNMDLGQLLYPPMQSVDIKALDLDIVHSGMDQRKIHMLVREIFPKMGWKPPVCVHHHLLPGLAEPVKLGLDENAAEDAKVSSKMSKSKPSSGILIHDDEKAIRDKMAKAFCPVGVAEGNPVLELVRYVVFHEFSEFTIERPAKYGGNTTYGSYKNVEDDFVAKKIHPMDLKNATATYVNRIIEPVYRHFKGREPALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPT3</accession>
    <name>A0A075MPT3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPT3"/>
    <dbReference type="STRING" id="1459636.NTE_01062"/>
    <dbReference type="KEGG" id="nev:NTE_01062"/>
    <dbReference type="HOGENOM" id="CLU_1478964_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="182" mass="19945" checksum="1459D3B3D4483E13" modified="2014-10-29" version="1">MLILTVFGTAVVSLDIVVLGQLVDKKLESVMILHDYFTVFAVMSGAGFIGLLAFSSETPQGAVNMLKILSIAAAASVFLIILTETIGYIEYRLPDPDSAKSKIKQTFPFAHEPMFESMEYMGLLGPMWAGLVAYLAWHYNDRMFTDRAVKSTLMAMISLAIMYALFISLMGIVPTKIASVQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQ98</accession>
    <name>A0A075MQ98_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQ98"/>
    <dbReference type="STRING" id="1459636.NTE_01172"/>
    <dbReference type="KEGG" id="nev:NTE_01172"/>
    <dbReference type="HOGENOM" id="CLU_2044301_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="120" mass="13001" checksum="4F84B2DA64190119" modified="2014-10-29" version="1">MPAAAEVEEEAEAAGDQEKEEGQGTVIRMLKLRVSMIIMYSKILQITLRPLALLLFDLTGKADRPAGALSPMSRTKVCGALMNLHIVIIFSVATRLQVISSISISLHAGAAEKRVKRAMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQK4</accession>
    <name>A0A075MQK4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01434</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQK4"/>
    <dbReference type="STRING" id="1459636.NTE_01434"/>
    <dbReference type="KEGG" id="nev:NTE_01434"/>
    <dbReference type="eggNOG" id="arCOG08819">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1387627_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="181" mass="18882" checksum="162D8DECA15985A8" modified="2014-10-29" version="1">MIVIGFTLPAIASMIIDEGRQTEGLGLRGNVDMILYDQSGNVKDERHLDNLIVSAGIEGVASRIAPHDGSVNPSAPYNYIALGTSNTPVDASQTVLSAELTTGANYARIQDTTALYSTASGNKLILSVTFGPGQATGTLRESGIFNSATGGNMLARQTFADIQKAAGDTLTVTWTITLSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQR4</accession>
    <name>A0A075MQR4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein uL6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpl6</name>
        <name evidence="7" type="ORF">NTE_01821</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQR4"/>
    <dbReference type="STRING" id="1459636.NTE_01821"/>
    <dbReference type="KEGG" id="nev:NTE_01821"/>
    <dbReference type="eggNOG" id="arCOG04090">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065464_0_0_2"/>
    <dbReference type="OrthoDB" id="7144at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.930.12:FF:000008">
        <property type="entry name" value="50S ribosomal protein L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="entry name" value="Ribosomal protein L6, alpha-beta domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01365_A">
        <property type="entry name" value="Ribosomal_uL6_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_uL6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_uL6-like_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_uL6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019907">
        <property type="entry name" value="Ribosomal_uL6_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002359">
        <property type="entry name" value="Ribosomal_uL6_CS2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004037">
        <property type="entry name" value="PRK05518.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03653">
        <property type="entry name" value="uL6_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF16">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="60S/50S RIBOSOMAL PROTEIN L6/L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002162">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="Ribosomal protein L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00700">
        <property type="entry name" value="RIBOSOMAL_L6_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 5" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="6">
        <location>
            <begin position="6"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="6">
        <location>
            <begin position="90"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF83881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="175" mass="19232" checksum="8BCFDD32AF54D844" modified="2014-10-29" version="1">MAEVAIPASVKVTKEGSFITVKGKLGTVKKDFLKLPATVTVEGNKVVIKPYGTRKRDLAVTNTARSIVTSMIKGVEKGYTYKVKIIFAHFPIAVKVKGKEVHVENFFGERSARIAKIQGDATKVEVQGEDVVVKGPSLEDVSQTAANIEQSTRIKDKDQRVFLDGLYVYSREEGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQX2</accession>
    <name>A0A075MQX2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQX2"/>
    <dbReference type="STRING" id="1459636.NTE_01545"/>
    <dbReference type="KEGG" id="nev:NTE_01545"/>
    <dbReference type="HOGENOM" id="CLU_1830653_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="153" mass="16970" checksum="339197722BBA8B23" modified="2014-10-29" version="1">MILDSTFYHSPYMSITEGDSEMTPATMTEAAGALEEVTETREQQQQQQQPSMPLPERTVTNEEVMIAQALSRIKKNAKVLEKTNKMLGQVLDSLKRAEKESAGHARQVASQNKKLASQIAQLQKRVAKIKSAPAAKPARKKKAAKAKAKPKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MR53</accession>
    <name>A0A075MR53_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mannosyl-3-phosphoglycerate synthase</fullName>
            <ecNumber evidence="1">2.4.1.217</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01978</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.217" evidence="1"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700689.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MR53"/>
    <dbReference type="STRING" id="1459636.NTE_01978"/>
    <dbReference type="GeneID" id="41597726"/>
    <dbReference type="KEGG" id="nev:NTE_01978"/>
    <dbReference type="eggNOG" id="arCOG04158">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028916_0_0_2"/>
    <dbReference type="OrthoDB" id="9468at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050504">
        <property type="term" value="F:mannosyl-3-phosphoglycerate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051479">
        <property type="term" value="P:mannosylglycerate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012812">
        <property type="entry name" value="Osmo_MPG_synth"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02460">
        <property type="entry name" value="osmo_MPGsynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09488">
        <property type="entry name" value="Osmo_MPGsynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="NCBIfam" id="TIGR02460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="401" mass="45062" checksum="9145415EDD89CA21" modified="2014-10-29" version="1">MKLDFPRYTERLGAVSIHGVQRIYELDSGKSKGFLTSHQTIKKFDYDEISNILHDMAIVVPVKDEKLKLLEGVLSGIPNECLVIIVSNSPRNPVDRFTMEAETVRQLGRFMDKRMIVMHQRDPALGDIFKKLGYDSILAPDGNVRSGKAEGMVIGMLIAKMYQKDYVGFIDSDNYVPGAVNEYVKIFAAGFGMASTPYSNIRVSWVFKPKVRNNSLQFSKWGRVSEVTNKNLNSMLSGITGFETEVIKTGNSGEHALSMPLAESLHYSSGYSIEPYEFVDIFEKFGGLLPSHYPNAIEKGVEIFQIETRNPHFHEDKGKLHLNEMLEAALATIAGSKICPPDLKEGLDDQIAHMSGVKAHKKPDYRKKYPVIEPISAIPIEEFGKNLREKVETFFRYGGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MR56</accession>
    <name>A0A075MR56_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01983</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700693.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MR56"/>
    <dbReference type="STRING" id="1459636.NTE_01983"/>
    <dbReference type="GeneID" id="41597731"/>
    <dbReference type="KEGG" id="nev:NTE_01983"/>
    <dbReference type="HOGENOM" id="CLU_2629853_0_0_2"/>
    <dbReference type="OrthoDB" id="10337at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="78" mass="9003" checksum="D72CB24B8FFBFEC5" modified="2014-10-29" version="1">MTTKSKQALLQEITEILKKNPERMYSREEILNLLSKMKSDDEIDGLLAELEVASSLKESKSEVYATCRGGTVYYKWNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRA2</accession>
    <name>A0A075MRA2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein SirB1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_01562</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700362.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRA2"/>
    <dbReference type="STRING" id="1459636.NTE_01562"/>
    <dbReference type="GeneID" id="41597344"/>
    <dbReference type="KEGG" id="nev:NTE_01562"/>
    <dbReference type="eggNOG" id="arCOG03032">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063810_1_0_2"/>
    <dbReference type="OrthoDB" id="8627at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032698">
        <property type="entry name" value="SirB1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31350:SF21">
        <property type="entry name" value="F-BOX ONLY PROTEIN 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31350">
        <property type="entry name" value="SI:DKEY-261L7.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13371">
        <property type="entry name" value="TPR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13369">
        <property type="entry name" value="Transglut_core2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Protein SirB1 N-terminal" evidence="2">
        <location>
            <begin position="51"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="237"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF83625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="297" mass="33331" checksum="788BC400DBBB8DA2" modified="2014-10-29" version="1">MAGLNIDSVVRDWQDCVVKHVVSRDDPTRLAEHALNLARILAYPDLDVNAALASIDGMGAKIAHTLKSKGISRPTLIIEQINEYLFNDQKFKPNTDDYYNPLNSYLNVVLERKTGIPITLSILYMRVAQGAGFPMLPVNFPAHFLAKHVMEGDNGEIIVDPFNGGRIMDDYALKALLERSFPHQNIAMTHAFVERATSAQVMTRMLNNLKSSYYEAQDMERYEVANEMVLAIDQYNPEAIRDKGVVLLKKGSTEGALDALNAYLEVNPEAEDADDVLDVIRQIREGTYGKKKEKEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRB0</accession>
    <name>A0A075MRB0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Alanine--tRNA ligase</fullName>
            <ecNumber evidence="13">6.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Alanyl-tRNA synthetase</fullName>
            <shortName evidence="13">AlaRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">alaS</name>
        <name evidence="15" type="ORF">NTE_01283</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>tRNA(Ala) + L-alanine + ATP = L-alanyl-tRNA(Ala) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:12540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:9923"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78497"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7" evidence="13"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRB0"/>
    <dbReference type="STRING" id="1459636.NTE_01283"/>
    <dbReference type="KEGG" id="nev:NTE_01283"/>
    <dbReference type="eggNOG" id="arCOG01255">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004485_4_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.130:FF:000010">
        <property type="entry name" value="Alanine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.54.20:FF:000005">
        <property type="entry name" value="Alanine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000004">
        <property type="entry name" value="Alanine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.54.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.550">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00036_A">
        <property type="entry name" value="Ala_tRNA_synth_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022429">
        <property type="entry name" value="Ala-tRNA_lgiase_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050058">
        <property type="entry name" value="Ala-tRNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03683">
        <property type="entry name" value="A-tRNA_syn_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777:SF9">
        <property type="entry name" value="ALANINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777">
        <property type="entry name" value="ALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00980">
        <property type="entry name" value="TRNASYNTHALA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101353">
        <property type="entry name" value="Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 13 15" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 13" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="8 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alanyl-transfer RNA synthetases family profile" evidence="14">
        <location>
            <begin position="70"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="588"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="592"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="692"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="696"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AIF83352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="908" mass="101063" checksum="F782D3051B5E4722" modified="2014-10-29" version="1">MFSQNPDRYYKVALFDKIGFQRRQCNLCGKHFWTLIDRQSCPDHENYGFIGRPPTTKRLDYVNAWKETEKFFSKNGHEIVRRYPVVCRWRDDLYFTIASIVDFQRVMNNQVVFELPANPLVVPQMCLRFNDIENVGLSGRHYTGFCMIGQTCNADAPGGYWKDRCIELDYGMLTQGLGIKPEEITFVEDVWMGAGAFGYSLEYFVRGLELGNAVFTEFEGDENNYRVMKNKIIDMGAGLERFSWVTMGTPTSYDCCFGPVVEKMLDMTGTDRDSEFLSRYFGAVASKLETTEGNVRELKAILAREMGLSYDQLAKMVAPHEAVYTVADHVRTLLFAISDGALPSNVGGGYNLRVILRRALSILERLNWQGVKLEDVADMQIDYLRQMYPELEEHRQDVRTILGLESGRYSGSRERMNGIVSSLKAKKSGELAVSDLIRLYESDGITPDYLVEQGVIPSVPSTFYTKLAELHTSVAGGGAEKAKPVRGLEGLPATELLYYKDESIREFDAKVLKIVDNKFVVLDRTAFYPRGGGQEPDTGEISGAKVVEVTKQADIVVHRIEDGGKLQEGQAVKGIVNGRRRDMVTKHHTATHVINSSARNNLGSWVWQNSAFKEENYGRLDITHHSALSKEEVQKIEQTANIAVRKNLPVDIKFYDRGDAEQKYSFRIYQGGVVPSSNVRIVNIDNWDIEACGGTHVRRTGEIGMIKIVKSERIQDGVVRLEFVAGEAAVNYMQNQDAQLSTIAQALGSSREKVLESFAKAMDDAESAKKKLRIMLRTVAETMARSVSENAKNLGGGDVKLYSVYDEELDEDYHIAVGEKAIEFDPSLVYVALVAKGAGMRVIVFAGEKARKCAKAGGIAKQVSAKLGGSGGGDDRFGQGGGRLKEKINEALLSAEEMIAAAAAKKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRE7</accession>
    <name>A0A075MRE7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Antitoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01602</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700394.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRE7"/>
    <dbReference type="STRING" id="1459636.NTE_01602"/>
    <dbReference type="GeneID" id="41597380"/>
    <dbReference type="KEGG" id="nev:NTE_01602"/>
    <dbReference type="eggNOG" id="arCOG08550">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_170073_1_1_2"/>
    <dbReference type="OrthoDB" id="11786at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003847">
        <property type="entry name" value="Put_antitoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02697">
        <property type="entry name" value="VAPB_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="78" mass="9027" checksum="A0D843B9202403AE" modified="2014-10-29" version="1">MPSITITISEEAYKVLKAAKKENESFSDVILRIFPRGDPRRILAYLQDHRPLDDETAESIRQANKELRRNFKASVPEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRY5</accession>
    <name>A0A075MRY5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01799</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700555.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRY5"/>
    <dbReference type="STRING" id="1459636.NTE_01799"/>
    <dbReference type="GeneID" id="41597564"/>
    <dbReference type="KEGG" id="nev:NTE_01799"/>
    <dbReference type="eggNOG" id="arCOG07960">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1253521_0_0_2"/>
    <dbReference type="OrthoDB" id="374375at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="220" mass="25604" checksum="955F5CDEF672F032" modified="2014-10-29" version="1">MTRIDELRAQERQLTKLINKWHAENEFRLVILYGTGGIGKTSYAMQTLKQVDPKGYRHRFIFPPSQFVQTVTYLRENNMRIPALVWDDMGFWMYSLDYSDPFVKAAIKFFNVARTVVSCIIGTTASMKMLTSAVRNMDAMSVKVVSATAKEPVSLAKGYRQSIQPNMMRLVKTVFEDEYPRHMEDDDFAWYKPLRDSYVNHAISLMQESIMSRSRRPMKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MS09</accession>
    <name>A0A075MS09_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01894</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MS09"/>
    <dbReference type="KEGG" id="nev:NTE_01894"/>
    <dbReference type="HOGENOM" id="CLU_184185_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="70" mass="8154" checksum="DDED7C5F143607FD" modified="2014-10-29" version="1">MLATDPLPGDCEVLSLIRKYSGIQGKYLIMETGFSHDRTIDAVKELVLRNVVHVDFSNYPRFWECRFYAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MS55</accession>
    <name>A0A075MS55_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01886</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MS55"/>
    <dbReference type="STRING" id="1459636.NTE_01886"/>
    <dbReference type="KEGG" id="nev:NTE_01886"/>
    <dbReference type="HOGENOM" id="CLU_2712611_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="72" mass="7720" checksum="3E454E9471358DF1" modified="2014-10-29" version="1">MVIAMAKIIGLGKFIVAGVCVAVWLNGFASLYQSWSDAGISAAMWLGGASVCLYWAMRDRRKAKASSQQPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MS85</accession>
    <name>A0A075MS85_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein archease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NTE_01604</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the archease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MS85"/>
    <dbReference type="STRING" id="1459636.NTE_01604"/>
    <dbReference type="KEGG" id="nev:NTE_01604"/>
    <dbReference type="eggNOG" id="arCOG04055">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111362_3_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.10.10">
        <property type="entry name" value="Archease domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01222">
        <property type="entry name" value="Archease_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002804">
        <property type="entry name" value="Archease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022952">
        <property type="entry name" value="Archease_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023572">
        <property type="entry name" value="Archease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036820">
        <property type="entry name" value="Archease_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001617">
        <property type="entry name" value="PRK00407.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12682">
        <property type="entry name" value="ARCHEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12682:SF11">
        <property type="entry name" value="PROTEIN ARCHEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01951">
        <property type="entry name" value="Archease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69819">
        <property type="entry name" value="MTH1598-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Archease" evidence="6">
        <location>
            <begin position="7"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF83667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="145" mass="16412" checksum="B97743B0756B6BBD" modified="2014-10-29" version="1">MVVAGGYRFLDHMTDAVIEAYGNTLEEAFVQGARGLVDTMVDISAVRPVTEIKIEAEGHDLESLLFDWLDKVMLLMVSDGVAMSEFSVKIQKQDDDSYSLTGTAKGEKIDLARHHYKVEIKAITYHEMLVRQENDRVTIRFLMDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSA4</accession>
    <name>A0A075MSA4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSA4"/>
    <dbReference type="STRING" id="1459636.NTE_01936"/>
    <dbReference type="KEGG" id="nev:NTE_01936"/>
    <dbReference type="HOGENOM" id="CLU_218574_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="35" mass="4216" checksum="B3C673917E12AA9F" modified="2014-10-29" version="1">MTRQDVMIIAMLFSMAASLFTIYKVKRWEKKYDIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSF5</accession>
    <name>A0A075MSF5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphomethylpyrimidine synthase</fullName>
            <ecNumber evidence="9">4.1.99.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NTE_02036</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SR1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="4.1.99.17" evidence="9"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSF5"/>
    <dbReference type="STRING" id="1459636.NTE_02036"/>
    <dbReference type="KEGG" id="nev:NTE_02036"/>
    <dbReference type="eggNOG" id="arCOG02741">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013181_2_2_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070284">
        <property type="term" value="F:phosphomethylpyrimidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.540">
        <property type="entry name" value="Radical SAM ThiC family, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038521">
        <property type="entry name" value="ThiC/Bza_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002817">
        <property type="entry name" value="ThiC/BzaA/B"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009895">
        <property type="entry name" value="PRK13352.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00190">
        <property type="entry name" value="thiC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30557:SF1">
        <property type="entry name" value="PHOSPHOMETHYLPYRIMIDINE SYNTHASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30557">
        <property type="entry name" value="THIAMINE BIOSYNTHESIS PROTEIN THIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01964">
        <property type="entry name" value="ThiC_Rad_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00407">
        <property type="entry name" value="phosphomethylpyrimidine_syntha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01114">
        <property type="entry name" value="phosphomethylpyrimidine_syntha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00113">
        <property type="entry name" value="Radical_SAM_Phosphomethylpyrim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="NCBIfam" id="TIGR00190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIF84093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="444" mass="48579" checksum="E7412A99A548657D" modified="2014-10-29" version="1">MNSARRGIATDEMKQVAKDEGVDLDFIVRGVASGSIIIPKNNARPQKIKVTGIGRGLKTKVNVNIGTSTLHQDLDEEVSKAKVAVKHGADTIMDLSDGGDLNLIRKTLLEAAPITFGTVPVYQAYWHGVEKFKNPLNITEDDFLDAFEKNVKDGVDYTTIHSGITNELARRVIEVQRHGGIVSKGGTITAAWMLKYEKENPYFEHFDYLCEIARKYDVTFSLGDALRPGSILDAHDELQVAEMINVARLAKRAHAKDVQVMIEGPGHVPLNEVAANVRLAKSLIGDIPYYVLGPLVTDVAAGYDHIASAIGAAVSAAEGVDLLCYLTPAEHLGLPTAEEVKEGLIAYRIAAHAGDLVKIRERAIKWDAAITEARRTLNWEKQIALSINPEEAERIHYRGGQHEGNNVPCTMCGSACVYIMLPQQRKPRAEEESSAAESQVRNSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSH1</accession>
    <name>A0A075MSH1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00212</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
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            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158384918.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSH1"/>
    <dbReference type="GeneID" id="43502546"/>
    <dbReference type="KEGG" id="nev:NTE_00212"/>
    <dbReference type="HOGENOM" id="CLU_3162926_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="47" mass="5490" checksum="B336A1CD34B8EC45" modified="2014-10-29" version="1">MEKGSLKAFFEGRTSREPVQEARLEEKSKKEKVRERGGKASYHEHEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSH4</accession>
    <name>A0A075MSH4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02482</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226986972.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSH4"/>
    <dbReference type="STRING" id="1459636.NTE_02482"/>
    <dbReference type="GeneID" id="68225775"/>
    <dbReference type="KEGG" id="nev:NTE_02482"/>
    <dbReference type="HOGENOM" id="CLU_210683_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="58" mass="6442" checksum="CA22429C4841878C" modified="2014-10-29" version="1">MHANTYPPADFHLSAVMTNKRCVSCKQEVEESNFVGNQCKDCHAAYLESLGGEDQYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSK9</accession>
    <name>A0A075MSK9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02058</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSK9"/>
    <dbReference type="STRING" id="1459636.NTE_02058"/>
    <dbReference type="KEGG" id="nev:NTE_02058"/>
    <dbReference type="HOGENOM" id="CLU_1665406_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="158" mass="17077" checksum="ADFC8E51CB2F9890" modified="2014-10-29" version="1">MITQLIMLVILVSTQPLNVAGAASGAPACDQSLWNHVYRPERLKVVNPCVSVTGVIKGIASELDGDLHILVKLDPRYSNLTKNNIANTIFQQGNLVVEAICRHETFLSGPKAACANFHQDLAIPPVSTHVEVVGSYVLDQGHFNWAEIHPVTSVTATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSP2</accession>
    <name>A0A075MSP2_9ARCH</name>
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        <submittedName>
            <fullName evidence="7">NADH:ubiquinone oxidoreductase subunit 2 (Chain N)</fullName>
            <ecNumber evidence="7">1.6.5.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NTE_02549</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.6.5.3" evidence="7"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701137.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSP2"/>
    <dbReference type="STRING" id="1459636.NTE_02549"/>
    <dbReference type="GeneID" id="41598244"/>
    <dbReference type="KEGG" id="nev:NTE_02549"/>
    <dbReference type="eggNOG" id="arCOG01540">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007100_1_5_2"/>
    <dbReference type="OrthoDB" id="29144at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00445">
        <property type="entry name" value="NDH1_NuoN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010096">
        <property type="entry name" value="NADH-Q_OxRdtase_suN/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22773">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01434">
        <property type="entry name" value="NADHDHGNASE5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="418"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="458"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="NADH:quinone oxidoreductase/Mrp antiporter transmembrane" evidence="6">
        <location>
            <begin position="129"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF84596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="503" mass="53379" checksum="CA47C42179027BB0" modified="2014-10-29" version="1">MVELTSTPILVTVILGVVGLAIPAIDAGRREKGIDRNKVYSAIAFGALAVAMGIVIFNVFSGEVMPAVAFGTDVLTDDLFGSFFAVALLLVSLMMTASSWNYWKGRSNPAAYYSLILLSSIGMVLIAYSTDLVMLLVAWELMSLPTYALAGFQKRDPVSNEAAIKYFMFGALSSALIVFAIGLVYGMTGTTNIGDSVKALTNLDPSMMPVGLLAIALFIAGFGFKMGLVPFHMWLPDAYEGSPATIGGLLASGTKKAGFAAALRVIVLGMFALNADWTLTLAILAVFTMTIGNLGAIMQRSVPRMLAYSSIAQAGYIMIGIALAPYSDQALSGSLFHIINHAVMKSAGFIAVAAVAITLASYSLEKYRGLGRRMPITAATFSIALLALAGVPPLNGFWSKLMIFGAAINAGPVVDWGPWLAIAGVLNSALSLGYYAWIMRKMYMEDAPDMKRVKEPRAMIAVLVFAVVFMVGFGIWHAPLIDFASKAVPDLSFISGAHAGPLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSP6</accession>
    <name>A0A075MSP6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphatidylserine/phosphatidylglycerophosphate/ cardiolipin synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00292</name>
        <name evidence="3" type="ORF">NTE_01136</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699371.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSP6"/>
    <dbReference type="STRING" id="1459636.NTE_00292"/>
    <dbReference type="GeneID" id="41596950"/>
    <dbReference type="KEGG" id="nev:NTE_00292"/>
    <dbReference type="KEGG" id="nev:NTE_01136"/>
    <dbReference type="eggNOG" id="arCOG02041">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_955117_0_0_2"/>
    <dbReference type="OrthoDB" id="346316at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="1">
        <location>
            <begin position="225"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF83209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="291" mass="33346" checksum="573127BD3A1C3F28" modified="2014-10-29" version="1">MGSRKQFRILYDGMLDIPTSLNGISVLSYDLDHLGKTNHKISVSFTVLHINQSNTVDDIRLYVLSRDQFVTWALNCLRNNNAYLCPVQYSHYSGQVPSGQVTLQVHSGGSLHFLLDNRYSTFSSKRVAIRIDEEWEEQTGQLDLVTTIPPHDRSLEDEAKRMICNCNHTLKIISPYADMSFVKDILEKSKSANIQIITRARDEFTSDKRQAFGFIKDNLKDNHRINNFVHSRIIIRDNEEALISSADLTQDGLMKQYNTGAIISDANVMRKLLKYFDEVWHQSTTVQTKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSR5</accession>
    <name>A0A075MSR5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fe-S oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NTE_01761</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700524.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSR5"/>
    <dbReference type="STRING" id="1459636.NTE_01761"/>
    <dbReference type="GeneID" id="41597531"/>
    <dbReference type="KEGG" id="nev:NTE_01761"/>
    <dbReference type="eggNOG" id="arCOG01363">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044464_1_0_2"/>
    <dbReference type="OrthoDB" id="2305at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051198">
        <property type="entry name" value="BchE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43409">
        <property type="entry name" value="ANAEROBIC MAGNESIUM-PROTOPORPHYRIN IX MONOMETHYL ESTER CYCLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43409:SF4">
        <property type="entry name" value="RADICAL SAM SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01082">
        <property type="entry name" value="B12-binding_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01095">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="11"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF83822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="293" mass="33541" checksum="F5E4F5A9DEA3DA7B" modified="2014-10-29" version="1">MELAYDYPLYRPPSEANSLIFQVTLGCSFNKCSFCNMYRTKEYAERPWEEIRAEIDMMARFYPDTRRIFLADGDALNMSKDRLVQILEYLYQKFPGIERISCYAMPKNLLQKTDEELQALYAAGLHMFYVGIESGNDVVLKKVTKGATGRSIVQACSKARKHGYVLSCMVILGLGGRKYTKEHIADTAKVLSEIAPDYVGALTLYLEEGVHDEFMSKYGEPFEFIDDVEVLDELERLVRDFDPKMPVVFRANHASNVYSIGGTMPDDRGKILSLIEGLKSHPEMLKPKFLRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSS9</accession>
    <name>A0A075MSS9_9ARCH</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700821.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSS9"/>
    <dbReference type="STRING" id="1459636.NTE_02151"/>
    <dbReference type="GeneID" id="41597876"/>
    <dbReference type="KEGG" id="nev:NTE_02151"/>
    <dbReference type="HOGENOM" id="CLU_123710_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="131" mass="12962" checksum="2B42964C91CF2F1C" modified="2014-10-29" version="1">MANARLVIGLILAAATFALALTNTLGGLLAVEAVLRNVALIGTMTIPLAAAAFIVGWNQRSVLMAGLLAASGIAVIIPATIATGFFAFIVVPGPILGVIYGLGILGLGIAKGIKSARAMPPSSPSAATAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSW1</accession>
    <name>A0A075MSW1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02623</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701197.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSW1"/>
    <dbReference type="STRING" id="1459636.NTE_02623"/>
    <dbReference type="GeneID" id="41598317"/>
    <dbReference type="KEGG" id="nev:NTE_02623"/>
    <dbReference type="HOGENOM" id="CLU_2930032_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="60" mass="6271" checksum="E6CCBCA09809B478" modified="2014-10-29" version="1">MLATRRIIDIIFVALAIVAACITAIVAAKAVTDAFKPTLDSGNSIQESSKLVITDPDANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSY6</accession>
    <name>A0A075MSY6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02246</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSY6"/>
    <dbReference type="KEGG" id="nev:NTE_02246"/>
    <dbReference type="eggNOG" id="arCOG01117">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_170329_2_1_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription regulator AsnC/Lrp ligand binding" evidence="1">
        <location>
            <begin position="30"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="88" mass="9906" checksum="44C7DC2131AE60FD" modified="2014-10-29" version="1">MHNLIDAYVRSYNVTSAIVLLNCRFPFDARIIDELNKLSAVTYVYRTSGIYDLILKVTANTENELHKTVGTEIGTIRNVDSILTMVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MT09</accession>
    <name>A0A075MT09_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01867</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MT09"/>
    <dbReference type="KEGG" id="nev:NTE_01867"/>
    <dbReference type="HOGENOM" id="CLU_2712610_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="72" mass="8170" checksum="1B703F4CDBC4E7EA" modified="2014-10-29" version="1">MAKRLCLLFKSRESLIYSSRLFYTNMALPLEVRGAIEQMIDLQITGMTAEDAAEKARAEFDKAKEKAKDALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MT20</accession>
    <name>A0A075MT20_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02302</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700939.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MT20"/>
    <dbReference type="STRING" id="1459636.NTE_02302"/>
    <dbReference type="GeneID" id="41598017"/>
    <dbReference type="KEGG" id="nev:NTE_02302"/>
    <dbReference type="HOGENOM" id="CLU_126369_0_0_2"/>
    <dbReference type="OrthoDB" id="6536at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043200">
        <property type="term" value="P:response to amino acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30154">
        <property type="entry name" value="LEUCINE-RESPONSIVE REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30154:SF34">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR AZLB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="C-terminal effector domain of the bipartite response regulators"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="166" mass="18553" checksum="CB3886D1FC52FF7D" modified="2014-10-29" version="1">MRKNTKTILTRDLNNKSLVRIDELDLKIISLLVSGRDNKQISKELKVPLSTVQRRTRMILAKDIVKNKIEPNYKKLGYNKGMIHASVKSSDVSLAAQKLAEIDGIISVAVHLGTSDIVAEFVYGDSTDVLETISKIWNIEGIDRVTWSQEVYAVPVHNKNVISALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MT44</accession>
    <name>A0A075MT44_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative translation initiation inhibitor, yjgF family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02234</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700892.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MT44"/>
    <dbReference type="STRING" id="1459636.NTE_02234"/>
    <dbReference type="GeneID" id="41597954"/>
    <dbReference type="KEGG" id="nev:NTE_02234"/>
    <dbReference type="eggNOG" id="arCOG01630">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100715_5_1_2"/>
    <dbReference type="OrthoDB" id="197953at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06154">
        <property type="entry name" value="YjgF_YER057c_UK114_like_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43857">
        <property type="entry name" value="BLR7761 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43857:SF1">
        <property type="entry name" value="YJGH FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="130" mass="14152" checksum="F87202FBB991260D" modified="2014-10-29" version="1">MEKRRRVSSGTKWESAVGYSRAVRAGSVVHVSGTTATDEEGNIVGIGDPYVQAVQAIMNIESALLQLGSSLEEVVRTRIYVKNIGDWEKIGAAHAKFFDKTRPATSMVEVSRFIDPDILVEIEAEAISGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MT55</accession>
    <name>A0A075MT55_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methyl-accepting chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_02343</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700976.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MT55"/>
    <dbReference type="STRING" id="1459636.NTE_02343"/>
    <dbReference type="GeneID" id="41598059"/>
    <dbReference type="KEGG" id="nev:NTE_02343"/>
    <dbReference type="eggNOG" id="arCOG02320">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047366_0_0_2"/>
    <dbReference type="OrthoDB" id="8523at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18773">
        <property type="entry name" value="PDC1_HK_sensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.950">
        <property type="entry name" value="Methyl-accepting chemotaxis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051310">
        <property type="entry name" value="MCP_chemotaxis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43531:SF11">
        <property type="entry name" value="METHYL-ACCEPTING CHEMOTAXIS PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43531">
        <property type="entry name" value="PROTEIN ICFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58104">
        <property type="entry name" value="Methyl-accepting chemotaxis protein (MCP) signaling domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="Methyl-accepting transducer" evidence="3">
        <location>
            <begin position="27"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF84395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="360" mass="39729" checksum="946EBCDAAAB0AB98" modified="2014-10-29" version="1">MHVEHAQENTRDNSSLETVAKLSEMLSSKTETAINEIDHINGETQVLAINALIEASRAGEAGKAFSVVAEEMSRLSRKIVDTTDKLRKESRGTISELKNLIKMQATNIRGVRLSDLALTNIDLIDRNLYERSCDVRWWAKDASMVAALSEKTQEGRDMASTRLGVILDAYTVYFDLVLCDIDGNVIANGRPQQFRSQGTNQRNAAWFESAMSTASNDQFGFQAVHRSPLVNDQMAVIFSCCVRENCQSNGKVLGVLGTVFNWEALAQEIVNKTPLSREEKANSRVCIVDGKGTVLADTDGKVLEDSIHFAGDAEVYGTSKGFVMKKYNDNDSCIAYAASTGYETYSSGWHSIVIQKLNSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MT76</accession>
    <name>A0A075MT76_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Prephenate dehydrogenase</fullName>
            <ecNumber evidence="3">1.3.1.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_01949</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.3.1.12" evidence="3"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700664.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MT76"/>
    <dbReference type="STRING" id="1459636.NTE_01949"/>
    <dbReference type="GeneID" id="41597696"/>
    <dbReference type="KEGG" id="nev:NTE_01949"/>
    <dbReference type="eggNOG" id="arCOG00245">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036672_1_1_2"/>
    <dbReference type="OrthoDB" id="24743at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008977">
        <property type="term" value="F:prephenate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004665">
        <property type="term" value="F:prephenate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3660.10">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046826">
        <property type="entry name" value="PDH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050812">
        <property type="entry name" value="Preph/Arog_dehydrog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003099">
        <property type="entry name" value="Prephen_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21363">
        <property type="entry name" value="PREPHENATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21363:SF0">
        <property type="entry name" value="PREPHENATE DEHYDROGENASE [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02153">
        <property type="entry name" value="PDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51176">
        <property type="entry name" value="PDH_ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prephenate/arogenate dehydrogenase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF84007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="285" mass="30866" checksum="70B2D8C0F62FF512" modified="2014-10-29" version="1">MLVAIIGAAGKMGAWFCRYFAARQGNEVSAFDVKPFQINNDVRSAASIADCVKNADLVMICVPVKRTPAVIKQCAQAMTRQNALLAEISSVKAKTLPALKKARQDIITLCVHPMFGPGASEEKKQLKMLAIPVRNKAKELDAINSIFAGMSVKVLPDARTHDRAIAAVLGLTYFTNVAFASILAREDLANLNEVGGTTFAVQAMLAQSVMTDEPELIAALIRDNPHAAGYMRQYMKEASALASVRGSLLGAKLKKTKKKLQKKADLEASYRRMYGIIGLLDKPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTB2</accession>
    <name>A0A075MTB2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTB2"/>
    <dbReference type="STRING" id="1459636.NTE_02300"/>
    <dbReference type="KEGG" id="nev:NTE_02300"/>
    <dbReference type="eggNOG" id="arCOG08690">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1551748_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="172" mass="19836" checksum="DAF049697289F669" modified="2014-10-29" version="1">MYTHSCKSIVGKEKIKWKIEYDYTYYKVYDNKGTLAGYFFPHYNKSTESEDEEIDNDDAIEKMNKNHEQVSQGTLLVPMTKLDLLDHEEGIGIDHAIASLDANLVRTRFWKDWLARNAKELSIYGARVYTAREDRNMLSVAIGIAGNITLGEKEVKEFLTPLLDRLHDDSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTF1</accession>
    <name>A0A075MTF1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226986959.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTF1"/>
    <dbReference type="GeneID" id="41598051"/>
    <dbReference type="KEGG" id="nev:NTE_02335"/>
    <dbReference type="HOGENOM" id="CLU_3148100_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="49" mass="5435" checksum="326A0DFC42D3CFD5" modified="2014-10-29" version="1">MAKPETVNRLCIKCHTKTVHEVRDRTVAGTKVVCTDCGFSQVVTKLETT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTF3</accession>
    <name>A0A075MTF3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carboxypeptidase regulatory-like domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_02838</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTF3"/>
    <dbReference type="STRING" id="1459636.NTE_02838"/>
    <dbReference type="KEGG" id="nev:NTE_02838"/>
    <dbReference type="HOGENOM" id="CLU_965063_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1120">
        <property type="entry name" value="Carboxypeptidase-like, regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13620">
        <property type="entry name" value="CarboxypepD_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="Carboxypeptidase regulatory domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF84876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="288" mass="30799" checksum="7A50EAAEE6F27220" modified="2014-10-29" version="1">MTTGEFEIRGQFAELQRKYKEYLPKVDPELIDELLLRQMENPSNPDPIFMVEVFTRPGLDTEKVRRYIIEKTGMSPAIYDNGTHYVTNQKLNLKILKEISDSDDVLEVTGEYTGGIGAYGASHEHREIENTRGAASGRGSPPEKEVPRYAEHEKKTSNLRIAVYTAAGIIGAVIIAGWVISGGMLPNANVGGGSNSANTAATIPGVPGAVHGFVAGPGGLPAIGASVIAAEQNTGHHANAFVSVNGQYFLDLPPGNYVIIAAYPDGTNRAVNGFVVGSGSEHRLDFAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTG9</accession>
    <name>A0A075MTG9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00513</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTG9"/>
    <dbReference type="STRING" id="1459636.NTE_00513"/>
    <dbReference type="KEGG" id="nev:NTE_00513"/>
    <dbReference type="HOGENOM" id="CLU_2930023_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="60" mass="6439" checksum="9A15C477158E39C1" modified="2014-10-29" version="1">MLPRLRIQIVHREVLADSLVSPVNPARVQPVVKVAQAELAVQAAKVGVAAFLTPLAMEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTS1</accession>
    <name>A0A075MTS1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF393 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00603</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699605.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTS1"/>
    <dbReference type="STRING" id="1459636.NTE_00603"/>
    <dbReference type="GeneID" id="41596466"/>
    <dbReference type="KEGG" id="nev:NTE_00603"/>
    <dbReference type="eggNOG" id="arCOG08747">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_161796_0_0_2"/>
    <dbReference type="OrthoDB" id="6714at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="140" mass="15719" checksum="55F15ED961B68B06" modified="2014-10-29" version="1">MSLSSTFARPLLIYDDKCYSCTKFARTASALSRGWIRTAGHYRSEEAKRAKEMIFPKGYDATRMFWLVNRSGAHGARSGLPPLAKEIVAGWFRGGRRNMDMFAPVCEYDGIAPSMSCYTPTNIFKRLAKMLSHGATFPFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTZ1</accession>
    <name>A0A075MTZ1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_02617</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTZ1"/>
    <dbReference type="KEGG" id="nev:NTE_02617"/>
    <dbReference type="HOGENOM" id="CLU_1954559_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF84660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="128" mass="13219" checksum="6A019FC6333AF19C" modified="2014-10-29" version="1">MIIELQVRIFKIYLIRYHILNRFANHLNKSRAIRYVMSSNQTTKIVLTGVVLLALAAMITAAVVSPDLAFAKKKHKHHHGGDVNIGGDGGDGGDGGDGGNAFCPGKDNECTGGDGGDGGDGGDGGDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MU47</accession>
    <name>A0A075MU47_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ASCH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00751</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MU47"/>
    <dbReference type="STRING" id="1459636.NTE_00751"/>
    <dbReference type="KEGG" id="nev:NTE_00751"/>
    <dbReference type="HOGENOM" id="CLU_1830651_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="148" mass="16746" checksum="E91ED9C557C9027E" modified="2014-10-29" version="1">MMIRNAYCFVCLQVWRLLSAYVVRIKEEQERMLYARQSLYVGIRRDWSLGSKILLIKKNVQGDSVIIGSATLEKIVELDALSNIEKKPCLENNWYGKMVFAMLARFLPAVPVSQTPLAGKQPALLHGLAITEDELYEIESLAGSKIIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MU83</accession>
    <name>A0A075MU83_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00816</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699772.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MU83"/>
    <dbReference type="STRING" id="1459636.NTE_00816"/>
    <dbReference type="GeneID" id="41596662"/>
    <dbReference type="KEGG" id="nev:NTE_00816"/>
    <dbReference type="HOGENOM" id="CLU_025660_0_0_2"/>
    <dbReference type="OrthoDB" id="376214at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="462" mass="51564" checksum="268946A993BE2555" modified="2014-10-29" version="1">MNSDLNAIIGCAFMVLMLAGAATHAPPIAVAQAAQPNDLTIIDDARSTTSNGDTDAIQTSKDDAEERPTLTVKALTANNEEVRMRATIKLADKTVKTGLTPITFQGTAGKTYQLTVENQEKMENATFSREGIIFNRWEDTDDTSRSRDVTMPDDGESLDLRAVYNKGDRATLEDLGVLQLVSHDLYDVVRDGPNPGNREDRRLNLSTVLDHGEDQIATGGEPRNSENIALHTVAVKLGKMHLDLIDKGMEPEEAREQTVQVYLQMVAKAYKDTFHEPLPEAAPNEHEQKQDGTENLTGDLAMRTVHAYVPSHIMVNGEDTPMLDRSLRGKTLSDEDMQQLSKPLDGTFDPFLRDVTIFLPQPDALPQKFTVDLLEKDSSFAEQFETDVSFEEFLHELKDGHFDKNEQVMSYIREDMAAGLLPVQDEDTNQQQDMGAPTEDEEEESEDDNSEEFKPSFLRDRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUD7</accession>
    <name>A0A075MUD7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00873</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUD7"/>
    <dbReference type="STRING" id="1459636.NTE_00873"/>
    <dbReference type="KEGG" id="nev:NTE_00873"/>
    <dbReference type="HOGENOM" id="CLU_1987511_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="125" mass="14802" checksum="2C94213D3ABE97AA" modified="2014-10-29" version="1">MSPYYNEKDTHDRVVAKLARCLKEKYPLHTIEPNVKYRRKRQGPPLRNGRDYYPDVVDYTDKIAYEVHWKGSRKEESFDWLPEGWKGVNVFIDDMSNPFAIIVRMPGYGFTFVECQRDSDPTSCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUE1</accession>
    <name>A0A075MUE1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02769</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701319.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUE1"/>
    <dbReference type="STRING" id="1459636.NTE_02769"/>
    <dbReference type="GeneID" id="41598458"/>
    <dbReference type="KEGG" id="nev:NTE_02769"/>
    <dbReference type="eggNOG" id="arCOG08785">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2747970_0_0_2"/>
    <dbReference type="OrthoDB" id="10149at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="6"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="70" mass="7900" checksum="4E22ABD69D48B417" modified="2014-10-29" version="1">MSSEYEQNVGQLLAEKKAELEELAKNPKENAVKISQLTLEIDSLEAMYENYNLGLNVFRRAQGGRAGLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUG8</accession>
    <name>A0A075MUG8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02289</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_075054101.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUG8"/>
    <dbReference type="STRING" id="1459636.NTE_02289"/>
    <dbReference type="GeneID" id="41598004"/>
    <dbReference type="KEGG" id="nev:NTE_02289"/>
    <dbReference type="eggNOG" id="arCOG03770">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2783847_0_0_2"/>
    <dbReference type="OrthoDB" id="1011at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="68" mass="7584" checksum="181A437745866296" modified="2014-10-29" version="1">MILFGKKKEVPPTIYTEETCSVCGEKMRRPFEEGDYVFRNGSTCKKCGSSSTMVSAVYGEYPPDKDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUH2</accession>
    <name>A0A075MUH2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Universal stress protein UspA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_00888</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699827.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUH2"/>
    <dbReference type="STRING" id="1459636.NTE_00888"/>
    <dbReference type="GeneID" id="41596728"/>
    <dbReference type="KEGG" id="nev:NTE_00888"/>
    <dbReference type="eggNOG" id="arCOG02053">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049301_11_2_2"/>
    <dbReference type="OrthoDB" id="105697at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00293">
        <property type="entry name" value="USP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46268">
        <property type="entry name" value="STRESS RESPONSE PROTEIN NHAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46268:SF6">
        <property type="entry name" value="UNIVERSAL STRESS PROTEIN UP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UspA" evidence="2">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF82964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="172" mass="18817" checksum="428F6BA4893135A2" modified="2014-10-29" version="1">MFKKILVPYDGSKPADKATRYAMDLAKAISRNSYADDDVAGCEIILLHVVPEIPASPVFIERPMSTSKGEHIPLSEYVRRLYAEMKVHAAEMLEKKKKEIETFLENRGTTVRTVVIIGDPVANKIVEQAASENVDLIVIGNVGLSGVSKLKTLGSVSRGVSERAPCPVMIVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUL8</accession>
    <name>A0A075MUL8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetyl-CoA carboxylase, carboxyltransferase component (Subunits alpha and beta)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_02772</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AccD/PCCB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701322.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUL8"/>
    <dbReference type="STRING" id="1459636.NTE_02772"/>
    <dbReference type="GeneID" id="41598461"/>
    <dbReference type="KEGG" id="nev:NTE_02772"/>
    <dbReference type="eggNOG" id="arCOG02705">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018822_6_2_2"/>
    <dbReference type="OrthoDB" id="30579at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009317">
        <property type="term" value="C:acetyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004658">
        <property type="term" value="F:propionyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000017">
        <property type="entry name" value="Propionyl-CoA carboxylase subunit beta 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000016">
        <property type="entry name" value="Propionyl-CoA carboxylase, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051047">
        <property type="entry name" value="AccD/PCCB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000438">
        <property type="entry name" value="Acetyl_CoA_COase_Trfase_b_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43842">
        <property type="entry name" value="PROPIONYL-COA CARBOXYLASE BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43842:SF2">
        <property type="entry name" value="PROPIONYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01070">
        <property type="entry name" value="ACCCTRFRASEB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="2">
        <location>
            <begin position="2"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="3">
        <location>
            <begin position="261"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF84813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="514" mass="56077" checksum="3E56C067B3F4301E" modified="2014-10-29" version="1">MHEEKVKRLAALKKSAESGGGDERIEAQHSKGKLTARERIALLLDEGSFVEIDKYVTHRGDDPTVQKFYGDGAVTGFGTVNGRQVFVFAYDFTVLGGSLGEMTSKKITKVMDHAMKVGCPIIGIIDSGGARIQEGVNSLDGYGDIFFRNTMASGVIPQITASIGPCAGGAVYSPAMTDFVVMVENIGQMFVTGPEVVKEVLSQDVSFEELGGARAHGSKSGVAHFVAKNEYDCFDRIKKLLSFIPQNNTEEPPMAAESTDDPNRVDANLINILPENPYQQYDMKEIIKSVVDNGDFFEVHELFADNILVGFARMGGRTVGIVANQPMYLAGALDINSSNKAARFIRFCDSFNIPIVTLVDTPGYLPGTDQEHNGIIRHGSKLLYAYCEATVPKVTCIVGKAYGGAYIAMGSKNLRADVNYAWPNAEIAVLGPEAAVTIIHRKELKTAPDAPMMKKKLAKDYRDKFANPYLAAERGIIDVVIDPMETRPMIIRALEALANKKEARPWKKHGNINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUM3</accession>
    <name>A0A075MUM3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional regulator, HxlR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NTE_03337</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701782.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUM3"/>
    <dbReference type="STRING" id="1459636.NTE_03337"/>
    <dbReference type="GeneID" id="41598986"/>
    <dbReference type="KEGG" id="nev:NTE_03337"/>
    <dbReference type="eggNOG" id="arCOG01057">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111585_5_2_2"/>
    <dbReference type="OrthoDB" id="10490at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33204">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR, MARR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33204:SF18">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="5">
        <location>
            <begin position="15"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF85366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="135" mass="15104" checksum="056DA139F9B7466B" modified="2014-10-29" version="1">MSETPSTEVKHGATCAVIDIWEVLGKRWSLLIIKNLSTKETIRFNELKRALSGISSTVLSERLLELEREGLVTKKIYPEVPPRVEYSLTAQAKELEVIIKELARWVGRWKRPQSVAAPAATVAKKEEQSSTTTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUQ5</accession>
    <name>A0A075MUQ5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02902</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUQ5"/>
    <dbReference type="STRING" id="1459636.NTE_02902"/>
    <dbReference type="KEGG" id="nev:NTE_02902"/>
    <dbReference type="HOGENOM" id="CLU_3362470_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="35" mass="4131" checksum="A854BE54BBA317DB" modified="2014-10-29" version="1">MLQKFCIIICKIQELSRYKLANSIFIATCIIRENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUT9</accession>
    <name>A0A075MUT9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Double-stranded DNA-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02934</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701452.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUT9"/>
    <dbReference type="STRING" id="1459636.NTE_02934"/>
    <dbReference type="GeneID" id="41598612"/>
    <dbReference type="KEGG" id="nev:NTE_02934"/>
    <dbReference type="eggNOG" id="arCOG05529">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1860787_0_0_2"/>
    <dbReference type="OrthoDB" id="9122at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002836">
        <property type="entry name" value="PDCD5-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01984">
        <property type="entry name" value="dsDNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="136" mass="15236" checksum="4A7A46873182CCD8" modified="2014-10-29" version="1">MSGSGDNDPDIEIIKARKMKEMREKAAAFEKAKNAPIAEEKKKMKTPREIVFSYLYDRGDEVLNAAYAQFPAQTEAIVVKISELILAGELQSRISGGELLSLFRSVGLRVRIDTSIKVEKDGKLISFSDRLKQDNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUW0</accession>
    <name>A0A075MUW0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase propeptide domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701438.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUW0"/>
    <dbReference type="STRING" id="1459636.NTE_02915"/>
    <dbReference type="GeneID" id="41598593"/>
    <dbReference type="KEGG" id="nev:NTE_02915"/>
    <dbReference type="HOGENOM" id="CLU_2534838_0_0_2"/>
    <dbReference type="OrthoDB" id="6198at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="84" mass="9568" checksum="1F34E4241DB2CD7E" modified="2014-10-29" version="1">MTPVRNQKDVEKAASRAIEALYGPEVKDLKIRVLLPFPNEHKQEGWDANVTFLLKGMQYTVDLLINQDDGQITNARLIDTMMPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUX5</accession>
    <name>A0A075MUX5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701487.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUX5"/>
    <dbReference type="GeneID" id="41598651"/>
    <dbReference type="KEGG" id="nev:NTE_02980"/>
    <dbReference type="eggNOG" id="arCOG08805">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100103_1_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="183" mass="20848" checksum="7DD5EF6D4D673079" modified="2014-10-29" version="1">MTPITESATFRFDKVVLEQLRREAEHKQVHLNTLVNQIVKSHIEWHTYAPQAGYIPVGKPLIRALVDSLTGEQIEEIGDRYAQTLSGPTLMITGKKLSAESILELVDRWVRASGFEYQHEEGKNNNNNHNHFRSVYVIQHNMGKNWSCLMARTLGQATSKFAAKAPNLQATENTLYIEFDLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MV75</accession>
    <name>A0A075MV75_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">YNCE-like beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_03523</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701929.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MV75"/>
    <dbReference type="STRING" id="1459636.NTE_03523"/>
    <dbReference type="GeneID" id="41599145"/>
    <dbReference type="KEGG" id="nev:NTE_03523"/>
    <dbReference type="eggNOG" id="arCOG02562">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG08716">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_560958_0_0_2"/>
    <dbReference type="OrthoDB" id="10730at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051200">
        <property type="entry name" value="Host-pathogen_enzymatic-act"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048433">
        <property type="entry name" value="YNCE-like_beta-prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011964">
        <property type="entry name" value="YVTN_b-propeller_repeat"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02276">
        <property type="entry name" value="beta_rpt_yvtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47197:SF3">
        <property type="entry name" value="DIHYDRO-HEME D1 DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47197">
        <property type="entry name" value="PROTEIN NIRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21783">
        <property type="entry name" value="YNCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="YNCE-like beta-propeller" evidence="3">
        <location>
            <begin position="221"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF85551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="486" mass="52247" checksum="46DB6C1CB6D54490" modified="2014-10-29" version="1">MADEAAESGGLLARRNLKARTFSGVSVVLLALSSLGIAFFSIPNDRMAANAHHVLDEIDVPGRPMRMSLAGDRLFVSNLGHNIVSVINTTTGHVIGNATVNTGVMAVEAVPEKNRLYIATFESGRIDVFALDSLKFLQGISLPGSQITFWYSPKHNFAEETTFLTGGWSMDYSPTNDMLYVANYNANLVTVIDTNTDKAVKSILVPDHPFIVKVDPVSKILLVASMASRSVTLVSTETNEIIDSVTTGCGPSGIAVDSQRSLAYITHRACFHIAVLDIATHKVVGQIPVGAIVDGITIDPSEHMLYASYMDKNSIIKIDSKTNEIISTIDMNDTVFDMVTDPATHNLYASTKFADKVLVIGPEAMATSLPVVTFETPVIVPGDIRVHGEDVTASDPMLHVVDKSLTMEVQSADGGDISIQIPRSMLDAQSEGADSKFQVLIDGKPVEYQQTASSSDSREITMFVPQGTHALTVTGTKAVIGFVQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MV98</accession>
    <name>A0A075MV98_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2H2 type zinc finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_01126</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700009.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MV98"/>
    <dbReference type="GeneID" id="41596940"/>
    <dbReference type="KEGG" id="nev:NTE_01126"/>
    <dbReference type="HOGENOM" id="CLU_1493021_0_0_2"/>
    <dbReference type="OrthoDB" id="12028at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF83199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="180" mass="21067" checksum="31E44AFE05F42D5D" modified="2014-10-29" version="1">MTRRVPDRSKDTIDSAVHRSMVDTEKINRAIERVARGDDDFIDDAIGKLKDLQFPAFKHKILEHVRNKTQDQDIIGLFEGLDGYIAFKDAYHIRKIIEENGTKYKQQYQISDETRKRPNFARQKIRGGGIKEREVANKSEERKDYPEIPPTTQSNYICDKCGKEFQNQHDLVNHKRFEGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVJ5</accession>
    <name>A0A075MVJ5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UDP-N-acetyl-D-mannosaminuronate dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.336</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_03156</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.336" evidence="3"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701629.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVJ5"/>
    <dbReference type="STRING" id="1459636.NTE_03156"/>
    <dbReference type="GeneID" id="41598815"/>
    <dbReference type="KEGG" id="nev:NTE_03156"/>
    <dbReference type="eggNOG" id="arCOG00252">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069297_0_0_2"/>
    <dbReference type="OrthoDB" id="59839at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089714">
        <property type="term" value="F:UDP-N-acetyl-D-mannosamine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028359">
        <property type="entry name" value="UDP_ManNAc/GlcNAc_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43491">
        <property type="entry name" value="UDP-N-ACETYL-D-MANNOSAMINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43491:SF1">
        <property type="entry name" value="UDP-N-ACETYL-D-MANNOSAMINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500136">
        <property type="entry name" value="UDP_ManNAc_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDP-glucose/GDP-mannose dehydrogenase dimerisation" evidence="2">
        <location>
            <begin position="179"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF85188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="288" mass="32529" checksum="077B184DFAE0800E" modified="2014-10-29" version="1">MNNNSNNKVLVIGLGQIGYSNAEYMTMKGLTVDGYDISEKAIQRAVDDQVIRKRAQSFAGYDYYIICISTHRPEDMFQPYLDGLFDIARQLLYEGKQGALVGIDSTITRGTSEKIKEILGHRLHVVHVPHRYFGPEKHDHGVNQTRVIGGCGECCIEAAKHFYGNLLDIPLHTVESVEVAELCKIVENSYRFMEIAFAEELKMFCDRSAIDFQELREAINTKWNIKVLEPREGIGGHCLPKDSQMFLNLSKNLLATSIIDAAKKVDEEYRAHIADVPSKKLPPIAQFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVN5</accession>
    <name>A0A075MVN5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_03189</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701654.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVN5"/>
    <dbReference type="STRING" id="1459636.NTE_03189"/>
    <dbReference type="GeneID" id="41598845"/>
    <dbReference type="KEGG" id="nev:NTE_03189"/>
    <dbReference type="HOGENOM" id="CLU_1870628_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF85218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="136" mass="14983" checksum="8BB088D7EF2EEB92" modified="2014-10-29" version="1">MKTQDAREQDLQPKIEYAKNALWTCSDMKNVEKASVYRDLEKAAKMLQLLHDYDGAKRILENYTSVIVNCRVASYFDSASTENETVTPPLFPGNPDVFGPPNGGGGTSEGSSSLIFLIPLAATAVFGALWYTTRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVP4</accession>
    <name>A0A075MVP4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transposase, IS605 OrfB family, central region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NTE_03199</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the transposase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVP4"/>
    <dbReference type="STRING" id="1459636.NTE_03199"/>
    <dbReference type="KEGG" id="nev:NTE_03199"/>
    <dbReference type="eggNOG" id="arCOG00679">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060889_0_0_2"/>
    <dbReference type="OrthoDB" id="210698at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Cas12f1-like_TNB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051399">
        <property type="entry name" value="RNA-guided_DNA_endo/Transpos"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040570">
        <property type="entry name" value="guided_TnpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01766">
        <property type="entry name" value="IS200/IS605 family accessory protein TnpB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30405">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30405:SF21">
        <property type="entry name" value="TRANSPOSASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="Cas12f1-like_TNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Probable transposase IS891/IS1136/IS1341" evidence="6">
        <location>
            <begin position="59"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Cas12f1-like TNB" evidence="7">
        <location>
            <begin position="186"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF85228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="289" mass="32831" checksum="496B4BDD6B6F0A97" modified="2014-10-29" version="1">MKVEKNPNTVSEYWARIPVKTVRGGVWVGIKPYEPLPMNAKICESRLYKQGSNWFLYLVVEQDVPEKSEYQNVIGIDMGIKHIATSVELASGKTIFYGKQLNRVRGHYFWLRKNLGKAKAIDTIKKIGERESRTTNDMLHKISREIVDQAIATDAAIVIGNLKHLRRNRIQQRRKRGARLLNSFPYSRLTQYIKYKAALEGIKVIEVSKAWTSQTCTECRNKGVRLTQGLFKCEHCHTEENADRNAAFNIAKRGLGYMSKLGVSVNMPRTSAMHSLSAMMSGEAIALAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVV7</accession>
    <name>A0A075MVV7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative copper export protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NTE_02715</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701273.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVV7"/>
    <dbReference type="STRING" id="1459636.NTE_02715"/>
    <dbReference type="GeneID" id="41598405"/>
    <dbReference type="KEGG" id="nev:NTE_02715"/>
    <dbReference type="eggNOG" id="arCOG05392">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_136219_0_0_2"/>
    <dbReference type="OrthoDB" id="4981at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032694">
        <property type="entry name" value="CopC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008457">
        <property type="entry name" value="Cu-R_CopD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34820">
        <property type="entry name" value="INNER MEMBRANE PROTEIN YEBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34820:SF4">
        <property type="entry name" value="INNER MEMBRANE PROTEIN YEBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05425">
        <property type="entry name" value="CopD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Copper resistance protein D" evidence="7">
        <location>
            <begin position="52"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF84757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="165" mass="17580" checksum="11A8668E55158CD2" modified="2014-10-29" version="1">MAVADGLVTWVHLICASIWVGGSIFIAAVAVPVLRSHTKSVEELVGLMVKLGRQFNKVTVPAFAILIVSGIYNARAFMSDPGALVDSNYGILLLIKIILVLATVGAYVVHVRTLNADMERRILSGNAGAVYVQSVRSKIIHLGRIIVFLSIAILLLAALLDSGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVW7</accession>
    <name>A0A075MVW7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03249</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVW7"/>
    <dbReference type="KEGG" id="nev:NTE_03249"/>
    <dbReference type="HOGENOM" id="CLU_1438064_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="188" mass="20825" checksum="FCFC734CFD1312E9" modified="2014-10-29" version="1">MNFRTGSNAIKNKKKKKTAVVTLSAASLVLLAGVLVVASSIAPAGNAQAASKGIAQNKYMEYVNHVHGGYKFLEKHTWHYNSTRSEADNLNAFKAWWCTDDSGKPIGSDKCKDMPAGDVKAFMQFVEKSRDKLLFDRVVQLQDEMGQHHSVKQWFIQAYNNGKPSQSATTDHTESEMKAMVQEAGNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVX3</accession>
    <name>A0A075MVX3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_03377</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701818.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVX3"/>
    <dbReference type="STRING" id="1459636.NTE_03377"/>
    <dbReference type="GeneID" id="41599023"/>
    <dbReference type="KEGG" id="nev:NTE_03377"/>
    <dbReference type="HOGENOM" id="CLU_1590795_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF85405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="167" mass="18358" checksum="D9B15A8423E3AEBA" modified="2014-10-29" version="1">MPHTIHVLVHAVALAWIGAILFFVPPLSTSSLPAIASLPPLLFWIVAWFADAGFTAKHWRLVMEGREANVLVLVLARLAPRKSKIVFAVHAAFSVGVATGLQSMVTHTFDLFLVSSILAAFGVLHLDAFFHSRTFVRTTTTTMMMGSQASEQQNPAEKETKKVLSFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVY4</accession>
    <name>A0A075MVY4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01397</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385185.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVY4"/>
    <dbReference type="STRING" id="1459636.NTE_01397"/>
    <dbReference type="GeneID" id="43502603"/>
    <dbReference type="KEGG" id="nev:NTE_01397"/>
    <dbReference type="eggNOG" id="arCOG06215">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3021093_0_0_2"/>
    <dbReference type="OrthoDB" id="7342at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="57" mass="6501" checksum="4AC671AF8755E884" modified="2014-10-29" version="1">MTMKTLMIDEQTYKRLASIRSEMSHAKKRDVDFGETINELINVYHDHLAFSGENAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MW21</accession>
    <name>A0A075MW21_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WD40-like beta propeller repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_03422</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TolB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MW21"/>
    <dbReference type="STRING" id="1459636.NTE_03422"/>
    <dbReference type="KEGG" id="nev:NTE_03422"/>
    <dbReference type="HOGENOM" id="CLU_693731_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="WD40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36842">
        <property type="entry name" value="PROTEIN TOLB HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="365"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF85450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="397" mass="42386" checksum="F0EFA3FCEE592222" modified="2014-10-29" version="1">MQNMRWTQVVLALSIMILLIVISLPDIKVIQAAETSNGNASATSKDLHDSSKLTKVTTFEISNTTQAATVLDISPDSKTIIFASNSGDAAKKSSLWAITLSNSSSNESAYGNPRLIELSLTTSFSNMFNPRISPDGSEILFVATYASSISDETKQGLFEYNLEKNTLAEVSLNIPTVRSADWVPNGTILYSGGNASSNSDTIWISSKNGTNSKQVYNSPEPVGDIDVSSDGTKVAFITSSQENVYASFLKVLDIKTGKTRILGNSTNNNENLPAAYHDPRWSPNNEFIVTTYSPKTLPASEIRLISIDGTINTPVYSNSSFNAVGAAITGGDGKSVIFGLAANNKDLQGESGIYMLQIDSAMPDFATGAALMAVVVMLGTSIFLGKAFITKYTGKQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MW36</accession>
    <name>A0A075MW36_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein uS5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">30S ribosomal protein S5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NTE_02797</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SR1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Part of the 30S ribosomal subunit. Contacts protein S4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MW36"/>
    <dbReference type="STRING" id="1459636.NTE_02797"/>
    <dbReference type="KEGG" id="nev:NTE_02797"/>
    <dbReference type="eggNOG" id="arCOG04087">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065898_0_1_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000004">
        <property type="entry name" value="40S ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_uS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047866">
        <property type="entry name" value="Ribosomal_uS5_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_uS5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005711">
        <property type="entry name" value="Ribosomal_uS5_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_uS5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003125">
        <property type="entry name" value="PRK04044.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01020">
        <property type="entry name" value="uS5_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718:SF4">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718">
        <property type="entry name" value="RIBOSOMAL S SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 9 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="S5 DRBM" evidence="11">
        <location>
            <begin position="55"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIF84837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="206" mass="22228" checksum="1410E8103816CC65" modified="2014-10-29" version="1">MSSMFSSQQQQAEWKPRTALGRDVLAGKITSMDQIYENGQRIQESEIVKHLLPDIKSQVVHVGIVQKQTDAGEMTRFNALVAVGNEAGWFGIGKGKASQMRLAIDKATNAAYLNVIPVKLGCGSWECKCTQLHSVPFKVRGKGGSVTLEIIPGPRGLGLVAGENIKNLLKLAGLKDSWTKTFGSTNTMSSTTKAVFNALRSTYSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MW40</accession>
    <name>A0A075MW40_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YcaO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02802</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701349.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MW40"/>
    <dbReference type="STRING" id="1459636.NTE_02802"/>
    <dbReference type="GeneID" id="41598490"/>
    <dbReference type="KEGG" id="nev:NTE_02802"/>
    <dbReference type="eggNOG" id="arCOG02882">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056369_0_0_2"/>
    <dbReference type="OrthoDB" id="7433at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.230">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003776">
        <property type="entry name" value="YcaO-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00702">
        <property type="entry name" value="YcaO-type kinase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37809">
        <property type="entry name" value="RIBOSOMAL PROTEIN S12 METHYLTHIOTRANSFERASE ACCESSORY FACTOR YCAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37809:SF1">
        <property type="entry name" value="RIBOSOMAL PROTEIN S12 METHYLTHIOTRANSFERASE ACCESSORY FACTOR YCAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02624">
        <property type="entry name" value="YcaO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51664">
        <property type="entry name" value="YCAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YcaO" evidence="1">
        <location>
            <begin position="73"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="445" mass="50059" checksum="4C2212312D68BACB" modified="2014-10-29" version="1">MPPRIELQSRKKWTVNGTSRIRPAQETLQKVMPLTKKIGVTRLADITDMDVLRIPNYSAVLPGTEDYIWVYSGKGPTREHAMASALMESIERYSSLPAGGPRNFVRASYAELSKSQKVLHPDEIVEPTRFEYRDDMLMDFLPGFDIANNNEEVMVPAPIALFRYNPPAPAVNPFSYFHTNGLASGNVMEEAVCHSLCEVIERDAMSVAELRASAIPFHVLRSIIHSLNAAGIQTKPMQADRFVDDPGIFPDVDISEVDFEPVRKLVKKFDRAAIPLIIKDITSDIGVPTFNASSIEWVTHDYGYLAEGHGTHPDARIALLRAITEVSQTRAANIQGARDDLRKIRYGENNTDDKRAWQFMPSTKKIKFSEVKTYFHEDILDDIKFILDRLRNAGLGRAIIVDLTNPDLAVPVVRAIVPGLETFKITKSVVGMRARALFRQWQKNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MW87</accession>
    <name>A0A075MW87_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701816.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MW87"/>
    <dbReference type="STRING" id="1459636.NTE_03375"/>
    <dbReference type="GeneID" id="41599021"/>
    <dbReference type="KEGG" id="nev:NTE_03375"/>
    <dbReference type="HOGENOM" id="CLU_1092393_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="254" mass="29279" checksum="08C46D325447B65A" modified="2014-10-29" version="1">MKKINQAQHRSDGNDNDDNYSTSIREATLGTAVQSRRLVNYNSKAFRILEQLFKASEPKHSSYRFATRAERNAMRRLVRAGLIKAETEEESMHDNNSNCCITSSSHLYTKYSITLAGRAHYVAAELGLSFPQLCYLACARNAVHNFIFTDDRVFFAKDVYTIFGLVFKDISPSITRWELARKGFLARYAWHISSLVRPHFVELERRYATVMDELYHWMKKEYDRQFAEAMHDPVIAKIVVGPAQPPITEGKRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWB1</accession>
    <name>A0A075MWB1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_03395</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701836.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWB1"/>
    <dbReference type="STRING" id="1459636.NTE_03395"/>
    <dbReference type="GeneID" id="41599041"/>
    <dbReference type="KEGG" id="nev:NTE_03395"/>
    <dbReference type="HOGENOM" id="CLU_2433701_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF85423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="90" mass="9576" checksum="4EDAD70CFDE33613" modified="2014-10-29" version="1">MSSSENPPPAAAPASEQSQSKQPDASIPVGHSPQKQEAPTDAQSKQGSKKGGSGWGLVIGIVLLGFAFGMGYYLYTKRNEEKEEKPVEQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWF4</accession>
    <name>A0A075MWF4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">GTP cyclohydrolase III</fullName>
            <ecNumber evidence="2 3">3.5.4.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">gch3</name>
        <name evidence="5" type="ORF">NTE_03547</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 3">Catalyzes the formation of 2-amino-5-formylamino-6-ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>GTP + 3 H2O = 2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + 2 phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:22468"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57258"/>
            <dbReference type="EC" id="3.5.4.29"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the archaeal-type GTP cyclohydrolase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.29" evidence="2 3"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701946.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWF4"/>
    <dbReference type="STRING" id="1459636.NTE_03547"/>
    <dbReference type="GeneID" id="41599165"/>
    <dbReference type="KEGG" id="nev:NTE_03547"/>
    <dbReference type="eggNOG" id="arCOG04202">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080076_0_0_2"/>
    <dbReference type="OrthoDB" id="25211at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043740">
        <property type="term" value="F:GTP cyclohydrolase IIa activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00608">
        <property type="entry name" value="GTP_cyclohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007839">
        <property type="entry name" value="GTP_CycHdrlase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42202">
        <property type="entry name" value="GTP CYCLOHYDROLASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42202:SF1">
        <property type="entry name" value="GTP CYCLOHYDROLASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05165">
        <property type="entry name" value="GCH_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009265">
        <property type="entry name" value="GTP_cyclohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF" evidence="4">
        <location>
            <begin position="131"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR009265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF85575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="253" mass="28165" checksum="57D2BC5646F61124" modified="2014-10-29" version="1">MIQLTIIRIEGYGPWTLTLGYDREAQLQMLQARIYHDVQRLFHEKDCLVYFNRFDEYFAITNGVSVEQHAEIAHALAILYTDLKMSMAIGTGKTALEASMNAYNARKENRLADEKARIFFSGPATTTTSETSAQIMHIDVDSSTKLTGRLSPYEVTALVMKLYGRLAEEFLKLDALTFFLGGDNFMVISNGVTGAQADKVITKVTADLGVKLNCGIGIGKNGRRAAEAATKALDTIRDMREEGKIQTIYEIRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWL3</accession>
    <name>A0A075MWL3_9ARCH</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01596</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="STRING" id="1459636.NTE_01596"/>
    <dbReference type="GeneID" id="41597376"/>
    <dbReference type="KEGG" id="nev:NTE_01596"/>
    <dbReference type="eggNOG" id="arCOG08725">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2044491_0_0_2"/>
    <dbReference type="OrthoDB" id="11174at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="120" mass="13629" checksum="44437A142876F4EB" modified="2014-10-29" version="1">MFEDWISAPAIALAVAYSWLAHNLGEPFAAFAKDFQFAAICTITIIFIMASMFIMLREAKKKLPKSYVVEIIDVYGDKVSIDGVRQTFATYDAAESYARMYRQNFSQYRFKVVGSQKVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWR3</accession>
    <name>A0A075MWR3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Plastocyanin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_03525</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701930.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWR3"/>
    <dbReference type="STRING" id="1459636.NTE_03525"/>
    <dbReference type="GeneID" id="41599146"/>
    <dbReference type="KEGG" id="nev:NTE_03525"/>
    <dbReference type="eggNOG" id="arCOG02926">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1709035_0_0_2"/>
    <dbReference type="OrthoDB" id="11836at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000923">
        <property type="entry name" value="BlueCu_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052721">
        <property type="entry name" value="ET_Amicyanin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36507">
        <property type="entry name" value="BLL1555 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36507:SF1">
        <property type="entry name" value="BLL1555 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00127">
        <property type="entry name" value="Copper-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Blue (type 1) copper" evidence="4">
        <location>
            <begin position="69"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF85553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="158" mass="17445" checksum="732045D8B4A437D3" modified="2014-10-29" version="1">MTSPLRLTNTAGISLMAFIVAVVASLVYYEYFYIPEANKKPTAPTEVLNPPGFSSVTIVEGSSNPNQAQNYVPKQVRATLGIDNKIVWTNKDTTFHSVTTDTGYVDPINGKFDSIASIGLVGPEQKYEFTFTRAGEYPYHCEPHPWMTGKVTIVENFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWS7</accession>
    <name>A0A075MWS7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NTE_01653</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWS7"/>
    <dbReference type="STRING" id="1459636.NTE_01653"/>
    <dbReference type="KEGG" id="nev:NTE_01653"/>
    <dbReference type="eggNOG" id="arCOG00273">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042632_1_0_2"/>
    <dbReference type="OrthoDB" id="78162at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050638">
        <property type="entry name" value="AA-Vitamin_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32322:SF2">
        <property type="entry name" value="EAMA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32322">
        <property type="entry name" value="INNER MEMBRANE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="295"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="7">
        <location>
            <begin position="28"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="7">
        <location>
            <begin position="174"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF83714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="314" mass="32947" checksum="4D93C426820D1D56" modified="2014-10-29" version="1">MRRAYLEPLTAPEQASPAGTQKKQQGYLGYLSVLIASALFGSVFAVTKVPLASIDPLALSAVIYVIAGLTLVPFAKASFRLQRREARYMIAITAFGAVAAPVLLLHGLQMTEASDASILANGEVLFTVILSSLFFGERPHGKLGLAAVALVIVGLFMATTDMKFSSGTIIELNAGNLMILASMFFWAIDNNFSRKLTTFSDISPAKMAMIKSLAGGLVLLGVTAAAGKWGALGNISAQLWLIIITLSASGFGGALLFFLAGIKRIGTIKTMAVFSMTPIFGIVIAAAALGESISVFQAIATGLIIIGILIVSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MXK4</accession>
    <name>A0A075MXK4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Class I SAM-dependent methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03313</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701762.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MXK4"/>
    <dbReference type="STRING" id="1459636.NTE_03313"/>
    <dbReference type="GeneID" id="41598964"/>
    <dbReference type="KEGG" id="nev:NTE_03313"/>
    <dbReference type="HOGENOM" id="CLU_1052177_0_0_2"/>
    <dbReference type="OrthoDB" id="6027at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="267" mass="30544" checksum="18ACE2AFA36B2F1E" modified="2014-10-29" version="1">MPFVTDDLRKAMASYVQFQRNAASPHHARYSFPFFAGTYFGYRKVDVLRVTAIAKAVNEKPSYLDVGCGYGDFLKRIREFLPGAQGLEKDAGIFYGLGIAKPDYIRIADAHWIDRKYDVIFVGWMEPGQDFRDPVAKSTDVIVTTLDQGISLAAEFDGHGFERVAWWRTPSWEDVNVEIMNCHYTRMPEEKRAQLAGMRGAHNLWYVYAKPNTAAKVKNALETQIAAETSVKERYDFESVLDECGFGYMQKLENPAVQDPLWHVRFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MY41</accession>
    <name>A0A075MY41_9ARCH</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385376.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MY41"/>
    <dbReference type="GeneID" id="43502641"/>
    <dbReference type="KEGG" id="nev:NTE_02140"/>
    <dbReference type="HOGENOM" id="CLU_3056951_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="53" mass="5809" checksum="07A877768F3FE933" modified="2014-10-29" version="1">MSKDVNEGGIGTEEAKDLELDEEARPVRKAGNTPVPEAAETDQKKRKGTRKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MY46</accession>
    <name>A0A075MY46_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycosyltransferase subfamily 4-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700815.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MY46"/>
    <dbReference type="STRING" id="1459636.NTE_02145"/>
    <dbReference type="GeneID" id="41597870"/>
    <dbReference type="KEGG" id="nev:NTE_02145"/>
    <dbReference type="HOGENOM" id="CLU_827987_0_0_2"/>
    <dbReference type="OrthoDB" id="11420at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="336" mass="37820" checksum="831172C43710B6C2" modified="2014-10-29" version="1">MLNILHVWDQAGVACVLAKYQRIQGCQSKVVITSNADKFGIYDFYSGGNNSGGGDDDDSNIVDVIARPEEFTETCLKKAEKADVIHVHSRAEMVPILRKRFGNSRIIVLHYHGTDIRGLKKKYNLPHRSIASDIAVAAIYTARRIRNRNTNPQAQKMADLVVVATPDLLERAPPSLVYVSNPVDVDHFRPAMKTSSAGKSTGQNDDNNSTKALTFNTETADLQLVMQHFEKTRLPYELEVYDRTKDPIKYQDMPAFLRKYGAYVDIRYVNGKVLENLSKTALEALACGLKVIDYQANIHTRLPPEHDPHNVASRFVDIYHGLLENSRGARRRLQQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MYH6</accession>
    <name>A0A075MYH6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, ArsR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700919.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MYH6"/>
    <dbReference type="STRING" id="1459636.NTE_02270"/>
    <dbReference type="GeneID" id="41597985"/>
    <dbReference type="KEGG" id="nev:NTE_02270"/>
    <dbReference type="eggNOG" id="arCOG01681">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097806_0_3_2"/>
    <dbReference type="OrthoDB" id="21363at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033788">
        <property type="entry name" value="HTH_metalloreg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38600">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38600:SF1">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="107" mass="12223" checksum="51981A0F8E067D6B" modified="2014-10-29" version="1">MDTFSAVADPTRRAMLDLLVERERTAGDLVNAFPSISQPAVSKHLKVLRDAGLVSVRVHAQQRIYTLEPKALAELDAWIAKYKVFWPERLDALEKYLSKKEKKSEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MYS3</accession>
    <name>A0A075MYS3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02362</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700994.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MYS3"/>
    <dbReference type="STRING" id="1459636.NTE_02362"/>
    <dbReference type="GeneID" id="41598078"/>
    <dbReference type="KEGG" id="nev:NTE_02362"/>
    <dbReference type="HOGENOM" id="CLU_2353303_0_0_2"/>
    <dbReference type="OrthoDB" id="375234at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="97" mass="10593" checksum="2F81F6C1B24621AD" modified="2014-10-29" version="1">MSTSIDIVNTILSSVTTVELMKLFQKNPNLIDTMEGVAKRIGQTAMQVENDVDKLVDLGVLVKIPSGKTTVLVLDKKRAHEIDTKIENMLGRQQGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MYT6</accession>
    <name>A0A075MYT6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02377</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CGI121/TPRKB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701006.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MYT6"/>
    <dbReference type="STRING" id="1459636.NTE_02377"/>
    <dbReference type="GeneID" id="41598092"/>
    <dbReference type="KEGG" id="nev:NTE_02377"/>
    <dbReference type="eggNOG" id="arCOG00536">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG02197">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1076055_0_0_2"/>
    <dbReference type="OrthoDB" id="11483at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2380.10">
        <property type="entry name" value="CGI121/TPRKB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013926">
        <property type="entry name" value="CGI121/TPRKB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036504">
        <property type="entry name" value="CGI121/TPRKB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011465">
        <property type="entry name" value="PRK14886.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08617">
        <property type="entry name" value="CGI-121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="MoaD/ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143870">
        <property type="entry name" value="PF0523-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="259" mass="28295" checksum="3367E39B53D960F4" modified="2014-10-29" version="1">MIKIRLLGGAKKAVGRSSLDFDRKQASVSEILTFLQGISQEPRLLQAGNLIIAVNGVDSQALSGPDTMAKEGDTVTIVTVVHGGMEDNRLSLWNVLVAGVYKLDDKDTGKLLDRLRAENPKVMVQAADAAAVYGRDHALGALDIVLEAMARNIMIANRPETEVLLRLACTDQIAEALKRARLREGEAGCFIAFSTDAQALKKFGEQISHEFTLDDSVILQSREKRKALAKTVGISQEVDDDKEFLDLLLERAAILIRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MZ95</accession>
    <name>A0A075MZ95_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mn2+/Fe2-transporter, NRAMP family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NTE_02520</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226986978.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MZ95"/>
    <dbReference type="STRING" id="1459636.NTE_02520"/>
    <dbReference type="GeneID" id="41598223"/>
    <dbReference type="KEGG" id="nev:NTE_02520"/>
    <dbReference type="eggNOG" id="arCOG04531">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020088_6_2_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015086">
        <property type="term" value="F:cadmium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034755">
        <property type="term" value="P:iron ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001046">
        <property type="entry name" value="NRAMP_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037982">
        <property type="entry name" value="Nramp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706:SF33">
        <property type="entry name" value="NATURAL RESISTANCE-ASSOCIATED MACROPHAGE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706">
        <property type="entry name" value="SOLUTE CARRIER PROTEIN FAMILY 11 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01566">
        <property type="entry name" value="Nramp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="329"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="398"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="437"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF84569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="459" mass="49090" checksum="A43D03E141769514" modified="2014-10-29" version="1">MVDSAADKKDAVPRPNDSSSPQDANRRPHKTKKMQSSFAKIIGPGVITGASDDDPSGIATYSQAGAKFGAGLLWMALFQYPLMSAIQEMCARIGLVTGNGLAAVMASKYSRKIVLPISVLLLAANTINIGADISAMAASTRLIFPQVPFIAASVAFAALMTAALIAVPYRRYVRVLKYLTLFLFAYVITAAIVGGKWDEILVASVVPHVEFSAEFAMLFVAIFGTTISPYLFFWQTSEEAEEDVDKGKKKEIDSPEKPRVSKKEVRLMKADVMVGMGFSQLIMWSIIVTTAGSLHANGVTDITTVEQAAKALEPLVNSFPHAGTISKSIFALGVIGTGLLSVPVLAGASGYALADVFGWKQGLSKKFGQARSFYLVIAASVIVGLSLNFLNIDPIQALVYSAVINAVVSVPILFVLLRIANDKKILGSRVNRRVSNVLGWLTFAIMAASVCIMLAAWGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MZP2</accession>
    <name>A0A075MZP2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02666</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226986992.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MZP2"/>
    <dbReference type="GeneID" id="41598357"/>
    <dbReference type="KEGG" id="nev:NTE_02666"/>
    <dbReference type="eggNOG" id="arCOG08684">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128582_1_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="122" mass="13858" checksum="562DB55E5071A005" modified="2014-10-29" version="1">MVDYDALCLKILDIDPKVRFASVADHLGRIVASQYRKNVKPLLTKEESELSVTQSILRMGTRSVFENKLGPTIFAFAMYERVKRATIPIRDPDSHCLMVSFDVEAEHEKIILQKIIPLLAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N039</accession>
    <name>A0A075N039_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein predicted to be involved in DNA repair</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NTE_02824</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701366.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N039"/>
    <dbReference type="STRING" id="1459636.NTE_02824"/>
    <dbReference type="GeneID" id="41598509"/>
    <dbReference type="KEGG" id="nev:NTE_02824"/>
    <dbReference type="eggNOG" id="arCOG01452">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2044304_0_0_2"/>
    <dbReference type="OrthoDB" id="2216at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.920">
        <property type="entry name" value="CRISPR-associated endonuclease Cas1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050646">
        <property type="entry name" value="Cas1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002729">
        <property type="entry name" value="CRISPR-assoc_Cas1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042206">
        <property type="entry name" value="CRISPR-assoc_Cas1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34353">
        <property type="entry name" value="CRISPR-ASSOCIATED ENDONUCLEASE CAS1 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34353:SF2">
        <property type="entry name" value="CRISPR-ASSOCIATED ENDONUCLEASE CAS1 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01867">
        <property type="entry name" value="Cas_Cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF84864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="120" mass="13973" checksum="7D26E19A558ECB80" modified="2014-10-29" version="1">MAGLPGNCDLDPAVCFLHELDESKESLVYDMQELSRWLVDLSVIQLLEEKKLKKFDFIVTENYHIRLKEQTAKALIERIKLNMNAKSIFKGRDMLLINQFYLGMYGRLQTLQAAKQSHCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N0K0</accession>
    <name>A0A075N0K0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">site-specific DNA-methyltransferase (adenine-specific)</fullName>
            <ecNumber evidence="2">2.1.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NTE_02974</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an N(6)-methyl-2'-deoxyadenosine in DNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15197"/>
            <dbReference type="Rhea" id="RHEA-COMP:12418"/>
            <dbReference type="Rhea" id="RHEA-COMP:12419"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90615"/>
            <dbReference type="ChEBI" id="CHEBI:90616"/>
            <dbReference type="EC" id="2.1.1.72"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the N(4)/N(6)-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.72" evidence="2"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987024.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N0K0"/>
    <dbReference type="STRING" id="1459636.NTE_02974"/>
    <dbReference type="REBASE" id="90013">
        <property type="entry name" value="M.NevSR1ORF2974P"/>
    </dbReference>
    <dbReference type="GeneID" id="41598645"/>
    <dbReference type="KEGG" id="nev:NTE_02974"/>
    <dbReference type="eggNOG" id="arCOG03416">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063430_1_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009007">
        <property type="term" value="F:site-specific DNA-methyltransferase (adenine-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1020.10">
        <property type="entry name" value="Adenine-specific Methyltransferase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023095">
        <property type="entry name" value="Ade_MeTrfase_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012263">
        <property type="entry name" value="M_m6A_EcoRV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012327">
        <property type="entry name" value="MeTrfase_D12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30481">
        <property type="entry name" value="DNA ADENINE METHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30481:SF4">
        <property type="entry name" value="SITE-SPECIFIC DNA-METHYLTRANSFERASE (ADENINE-SPECIFIC)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02086">
        <property type="entry name" value="MethyltransfD12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000398">
        <property type="entry name" value="M_m6A_EcoRV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00505">
        <property type="entry name" value="D12N6MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF85009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="299" mass="34677" checksum="127E699779B899B8" modified="2014-10-29" version="1">MDDIMDSAATKPWKPVNSPIKWVGGKYKARDLIVNVIPPHHCYVEVFAGAAWVLFRKPPSRVEVYNDIDQDVVNFFRIVKEQPEEFVKSFDLELVSRAEFDRLKNIAPETLDPVARAHRFYYLIMAGWGGELDYPRFQTSISDGGGGNRLVGALKTLRSRIEPIHDRLKTVLIENLDWRQLVDRYDDSRTVMYLDPPYPDNNCNYQHNMRRIEEHKELADWMRTAKSKLILTCYNKPEIRALYSDFHIMEINFAAGMISKGGERLNKELIVANFKLGKELELKCTRQGKKKLDTSASFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N0S7</accession>
    <name>A0A075N0S7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Inositol monophosphatase/fructose-1,6-bisphosphatase family protein</fullName>
            <ecNumber evidence="4">3.1.3.25</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_03039</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="3.1.3.25" evidence="4"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701539.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N0S7"/>
    <dbReference type="STRING" id="1459636.NTE_03039"/>
    <dbReference type="GeneID" id="41598708"/>
    <dbReference type="KEGG" id="nev:NTE_03039"/>
    <dbReference type="eggNOG" id="arCOG01349">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044118_5_0_2"/>
    <dbReference type="OrthoDB" id="58111at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008934">
        <property type="term" value="F:inositol monophosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006020">
        <property type="term" value="P:inositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20854">
        <property type="entry name" value="INOSITOL MONOPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20854:SF4">
        <property type="entry name" value="INOSITOL-1-MONOPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600760-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF85074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="274" mass="30461" checksum="5A4257672BDFA664" modified="2014-10-29" version="1">MRLANQQAHYLELEEKDVLRHSLAAGRQAAKLLKDNFGDSATYDVSIKHDRSLVTRVDGESQALIMSYLKGQFPDIPFVAEEQDRQVNAGVKKDGYYFVIDPLDGTASFVIGIPFFCTSIALCKGTQTLAGVLVDPNHNEEFTAVLGGGAFLNGNRMSVTKRRNIEELYLNVNHTKFDQNRFERINANILKKIRRFHKLGSLCLEVAYVASGRLDGTINNDLSMWDIAAAGLILEEAGGRWTLLDGSKPAFPVFEKLDIVATNGIIHYDLLRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N1F2</accession>
    <name>A0A075N1F2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701729.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N1F2"/>
    <dbReference type="STRING" id="1459636.NTE_03270"/>
    <dbReference type="GeneID" id="41598925"/>
    <dbReference type="KEGG" id="nev:NTE_03270"/>
    <dbReference type="HOGENOM" id="CLU_1922680_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="131" mass="15020" checksum="0CD05C4CD2B91C95" modified="2014-10-29" version="1">MASTRRIGITPREKKEIAIPVARRLRTDVLEFGFKRSLFDVVSYDDDENLLRIVECKITSRITNIGGTFGQLLAYTALISSNGKDFLEAVLHEKRWNIPLNTITRMLESKTIPVAFYVAFRKQDVEDKKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N201</accession>
    <name>A0A075N201_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ammonia monooxygenase/methane monooxygenase, subunit C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03451</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701880.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N201"/>
    <dbReference type="STRING" id="1459636.NTE_03451"/>
    <dbReference type="GeneID" id="41599086"/>
    <dbReference type="KEGG" id="nev:NTE_03451"/>
    <dbReference type="eggNOG" id="arCOG08699">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1444620_0_0_2"/>
    <dbReference type="OrthoDB" id="5728at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22188">
        <property type="entry name" value="arch-AMO_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.50">
        <property type="entry name" value="Particulate methane monooxygenase subunit c2. Chain: C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006980">
        <property type="entry name" value="NH3_CH4_mOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023349">
        <property type="entry name" value="NH3_CH4_mOase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04896">
        <property type="entry name" value="AmoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="187" mass="21006" checksum="B271997B52E2C310" modified="2014-10-29" version="1">MAQMPSLIPKEVEIQRLKKVYIMVIALGSIAASVEVDNFIDASLHQTAIRDSAFTPAHWWLYSHFVALPLGWGMIAFYSRKTPILRGPGNSIPTGLKITIIGYLATMFTIGVNELWHFWFVEEIFSVPNHWMFNTGIVVAFMGALAFVVRVYARLVELGAETPAKNPYVAELYKLALEGKLYSRSIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N290</accession>
    <name>A0A075N290_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03531</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701933.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N290"/>
    <dbReference type="STRING" id="1459636.NTE_03531"/>
    <dbReference type="GeneID" id="41599149"/>
    <dbReference type="KEGG" id="nev:NTE_03531"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="203" mass="22535" checksum="73BA2B2BCCED364E" modified="2014-10-29" version="1">MSGGLEDEDTSWEERRDSDLEGIMGQLQITQCQVSRLRRVLANRLDRSNPATAAFSKGSSTYAFRSAGVAYRITIEADLVDDFGKKPILRSVGNKLRSPVFLIMVALFSAILSVIALTGLYWNSPALATLSDKELAMADRQYSVLLDSCTALSHDRPDPRASGAAYSICNKGIAQLQEFCRNHHTRVCEDERIELYTTAKRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLC3</accession>
    <name>A0A075MLC3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLC3"/>
    <dbReference type="STRING" id="1459636.NTE_00129"/>
    <dbReference type="KEGG" id="nev:NTE_00129"/>
    <dbReference type="HOGENOM" id="CLU_136580_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="165" mass="18878" checksum="8B7411AFBB70A2DA" modified="2014-10-29" version="1">MLKCSKFSDFLWIFNPPIFIAIFANVVITMVKVTKSVYIEIEKDGQKITFGPDEIEDIKRQLDAAIREKGREFHAKTKARRKVKALAKVATVYHMSDDKKKEIINNVNKKLSGTPKTLSALLDGVSYVPNYLPVIRKMVESQQNVARKQVGKRTLYYLKDGKNTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLM4</accession>
    <name>A0A075MLM4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00094</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699227.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLM4"/>
    <dbReference type="STRING" id="1459636.NTE_00094"/>
    <dbReference type="GeneID" id="41596039"/>
    <dbReference type="KEGG" id="nev:NTE_00094"/>
    <dbReference type="HOGENOM" id="CLU_1275364_0_0_2"/>
    <dbReference type="OrthoDB" id="380738at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="184" mass="20372" checksum="3A938E74FFD02A88" modified="2014-10-29" version="1">MKKQNIAQYNDTHRSVVAFLLLAVAATIIAAAAYPEYSLVNLQRLAAGEMMLPDSNNVVIVKFTSLSAYDSNHNYLGNIKDNMTFRFGEPVFLQANFTNSKSPSGNNNYLAIIEVRNSNTSETMVFSSVQTEKFAEAGNLAIGTYWKPDQKASYTILVFLLQKPEDLNKTPIQPPISSVRVQVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLP1</accession>
    <name>A0A075MLP1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">NH(3)-dependent NAD(+) synthetase</fullName>
            <ecNumber evidence="8 10">6.3.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">nadE</name>
        <name evidence="12" type="ORF">NTE_00116</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>deamido-NAD(+) + NH4(+) + ATP = AMP + diphosphate + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21188"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (ammonia route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 9">Belongs to the NAD synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.5" evidence="8 10"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987089.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLP1"/>
    <dbReference type="STRING" id="1459636.NTE_00116"/>
    <dbReference type="GeneID" id="41596056"/>
    <dbReference type="KEGG" id="nev:NTE_00116"/>
    <dbReference type="eggNOG" id="arCOG00069">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059327_1_1_2"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00333"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003952">
        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008795">
        <property type="term" value="F:NAD+ synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00553">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000106">
        <property type="entry name" value="Glutamine-dependent NAD(+) synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00193">
        <property type="entry name" value="NadE_ammonia_dep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022926">
        <property type="entry name" value="NH(3)-dep_NAD(+)_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00552">
        <property type="entry name" value="nadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010587">
        <property type="entry name" value="PRK13980.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090:SF9">
        <property type="entry name" value="GLUTAMINE-DEPENDENT NAD(+) SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="NH 3 /GLUTAMINE-DEPENDENT NAD + SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8 9" id="KW-0520">NAD</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD/GMP synthase" evidence="11">
        <location>
            <begin position="29"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="51"/>
            <end position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="8">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="8">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="8">
        <location>
            <begin position="268"/>
            <end position="269"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIF82198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="279" mass="30256" checksum="D374D50AC14603CB" modified="2014-10-29" version="1">MNYYYSSSSPESRVLARLTSGFDRAKTAKSIEKFIAGYVEAARAERGIVMGLSGGLDSAVVAALCTRALDGSGKNVLGLILPSASTPNEDVEDAAAHARELGIEHQTINMEPIVERYMQVLSDDNEDKVARGNLTARVRMSVLYYHAHVGKRLVAGTSDKSEISIGYFTKFGDGGADMIPIAGLYKTQVRELGRYLKVPDAILQKKSSPRLWADHTAEDEIGMGYETIDPILYMLVDRKKTAKEAAVALGVPVDKVKKVQGMIAKSAHKRAMPAAPPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLT6</accession>
    <name>A0A075MLT6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative nuleotide-utilizing enzyme, moeA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00016</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699171.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLT6"/>
    <dbReference type="STRING" id="1459636.NTE_00016"/>
    <dbReference type="GeneID" id="41595970"/>
    <dbReference type="KEGG" id="nev:NTE_00016"/>
    <dbReference type="eggNOG" id="arCOG00215">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030805_0_5_2"/>
    <dbReference type="OrthoDB" id="372037at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00885">
        <property type="entry name" value="cinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="entry name" value="MoaB/Mog-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050101">
        <property type="entry name" value="CinA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13939">
        <property type="entry name" value="NICOTINAMIDE-NUCLEOTIDE AMIDOHYDROLASE PNCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13939:SF0">
        <property type="entry name" value="NMN AMIDOHYDROLASE-LIKE PROTEIN YFAY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="Molybdenum cofactor biosynthesis proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoaB/Mog" evidence="1">
        <location>
            <begin position="5"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="266" mass="28903" checksum="5983948A699F6EC0" modified="2014-10-29" version="1">MMIIEILCVGNELLSGITLNTNAHWIAAQVAKAGGTVSRVTVVRDELSAISSAVNESLGRKPDILVTTGGLGATYDDMTLEGVAQALGRKAVLDKTAVEMLKTSYKRRHLRYRINKVRLKMATIPEGSVPIENPVGSAPSVMLDIGTRVFCVPGVPTEMKAVFKKHILPLVQKGVGSFVSREANYFVMGVSEGMIAPALVKIVDANSRDAVYLKTHPRGYYKKTTPRIRVHLVCKGADKEHVARMLARISGQLLKDIARLGGRIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLV0</accession>
    <name>A0A075MLV0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcriptional regulator, CopG family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NTE_00031</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transcriptional regulatory CopG/NikR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLV0"/>
    <dbReference type="STRING" id="1459636.NTE_00031"/>
    <dbReference type="KEGG" id="nev:NTE_00031"/>
    <dbReference type="eggNOG" id="arCOG01008">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113319_0_1_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22231">
        <property type="entry name" value="RHH_NikR_HicB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1150">
        <property type="entry name" value="ACT-like. Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="entry name" value="Met repressor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027271">
        <property type="entry name" value="Acetolactate_synth/TF_NikR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002145">
        <property type="entry name" value="CopG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050192">
        <property type="entry name" value="CopG/NikR_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014864">
        <property type="entry name" value="TF_NikR_Ni-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34719">
        <property type="entry name" value="NICKEL-RESPONSIVE REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34719:SF3">
        <property type="entry name" value="NICKEL-RESPONSIVE REGULATOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08753">
        <property type="entry name" value="NikR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01402">
        <property type="entry name" value="RHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="Ribbon-helix-helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Ribbon-helix-helix protein CopG" evidence="5">
        <location>
            <begin position="17"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor NikR nickel binding C-terminal" evidence="6">
        <location>
            <begin position="71"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF82115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="140" mass="15925" checksum="A968B596AA1674DE" modified="2014-10-29" version="1">MEVFIKLLITNVAVPIVSVSLNDDILAEMDVLQKALGFTGRSEIVRAGIRQLAAEEKDRQDLVGFIHALLMVVHNEESEKQVTDMKHDYDDLIQTHLHSKIHGDRCLEVFLLKGEAEGVKRMTKEFQSNKKMDHVKLISM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLZ9</accession>
    <name>A0A075MLZ9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00186</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699293.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="41596115"/>
    <dbReference type="KEGG" id="nev:NTE_00186"/>
    <dbReference type="HOGENOM" id="CLU_2550394_0_0_2"/>
    <dbReference type="OrthoDB" id="378476at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="92" mass="10346" checksum="D6D7391925D121A6" modified="2014-10-29" version="1">MMKGRCNEMVAAVRNMPLKEFQRRLTKLLGTTTTESIVRVLESNGVVKDNEVDISRLQGSFESLFQDAGVLLINEIVKEPNAVQDNVHKTQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MM70</accession>
    <name>A0A075MM70_9ARCH</name>
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        <submittedName>
            <fullName evidence="2">AAA+ family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
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    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MM70"/>
    <dbReference type="STRING" id="1459636.NTE_00500"/>
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    <dbReference type="eggNOG" id="arCOG01308">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016564_1_0_2"/>
    <dbReference type="OrthoDB" id="147168at2157"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19481">
        <property type="entry name" value="RecA-like_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054472">
        <property type="entry name" value="WHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF3">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22977">
        <property type="entry name" value="WHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="445"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
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            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="660" mass="72420" checksum="E58B303C8BD4B368" modified="2014-10-29" version="1">MTQEWASKNQKYMVSFIDYVKELLRNSTTQSGASSTPPQGPVWDAEANAPVHTASMPAIEQLSAAFGLSEFEKSLLVLCSAVELDSEVPKLCAKVNGNPDATFATFSLALSVLPDAHWSALVPTSPLRRFRLIELYGQGPVTGCQLRIDERVLHYLVGISYLDKSVHGLFEPVATADAAGESQRAIALSIVNAWKYAEMTGGQPLGIIQLVGPDEASKKQVAGQACGQLGLNLWQIAGDLLPSKADELEALTQLWIRESVLLRASLYICAHDVEQSAAQKLVTRFAGRLSGLSFLSRRDASPADTLPALSFNVSKPTKAEQRAIWQGLLLKDVSSEKAELCNQAIVRAVNQFNLNIESIQSAAYEAHLSISGGEQPASAIWHACQKVALPRLPDLAQRIVPHVTLEDIVLPDREKDLLGSIVATVRQRYKVYEEWGFGMREGRGLGIAALFAGDSGTGKTMSAEAIAGELGLDLYRIDLSMVVSKYIGETEKNLRRVFDAAEDGGAILFFDEADALFGKRSEVKDSHDRYANIEVGYLLQRIETYRGLAILTTNMKGALDSAFVRRIKFLVNFPFPDERSRKEIWKKIMPKAALGNKPLDYDLLARLDVTGGGIYNIALTAAFLAADEETQVEMRHVMKAAKQEYDKMERPMPEIGWSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMA4</accession>
    <name>A0A075MMA4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00168</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMA4"/>
    <dbReference type="KEGG" id="nev:NTE_00168"/>
    <dbReference type="HOGENOM" id="CLU_3194326_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="45" mass="5407" checksum="87B0A8FAC11183DF" modified="2014-10-29" version="1">MIFSKPIFMTEEVEKGQNTLVIFFRLRMAIASKQDLLWHSFSFIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MME5</accession>
    <name>A0A075MME5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00223</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699317.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MME5"/>
    <dbReference type="STRING" id="1459636.NTE_00223"/>
    <dbReference type="GeneID" id="41596143"/>
    <dbReference type="KEGG" id="nev:NTE_00223"/>
    <dbReference type="HOGENOM" id="CLU_113183_0_0_2"/>
    <dbReference type="OrthoDB" id="317279at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="158" mass="18444" checksum="99397C807F21FEDE" modified="2014-10-29" version="1">MSSYGELWAVLGNWRKEFSSGDFARTFYSPDPNKVLHDMARKGMLERVSTGRYRVRSTSEYVFSKYDAGRAYDFLRKAKLPYALTNVDAVYAWTRGGYNTDRFFGFYPVHVRVARDDLPEWRKMLAERGWKSVLSGENPRDTVRAVLHTLPRERKDKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMI3</accession>
    <name>A0A075MMI3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative enzyme involved in biosynthesis of extracellular polysaccharides</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
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            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82676.1"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMI3"/>
    <dbReference type="GeneID" id="41596458"/>
    <dbReference type="KEGG" id="nev:NTE_00595"/>
    <dbReference type="eggNOG" id="arCOG08661">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="17"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="108" mass="12293" checksum="7972449D6A03114E" modified="2014-10-29" version="1">MADQLVEKRALLEGQMFVAIADIELKKGKEDEFKKWFVQSNHILAGQDGFIARKLLKSPRGSHRILVIMESKEAFARMHTTPEHAKLHMEALAFMTRPPKISAYDSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMP1</accession>
    <name>A0A075MMP1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00333</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMP1"/>
    <dbReference type="STRING" id="1459636.NTE_00333"/>
    <dbReference type="KEGG" id="nev:NTE_00333"/>
    <dbReference type="HOGENOM" id="CLU_3302554_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="39" mass="4661" checksum="7DF632E146D1E1D1" modified="2014-10-29" version="1">MMITNGIVEKRADGAQTPILFFETKKRKKIRMRLFYTVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MN21</accession>
    <name>A0A075MN21_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fido domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00463</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MN21"/>
    <dbReference type="STRING" id="1459636.NTE_00463"/>
    <dbReference type="KEGG" id="nev:NTE_00463"/>
    <dbReference type="eggNOG" id="arCOG03112">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040460_3_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3290.10">
        <property type="entry name" value="Fido-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003812">
        <property type="entry name" value="Fido"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036597">
        <property type="entry name" value="Fido-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040198">
        <property type="entry name" value="Fido_containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13504:SF38">
        <property type="entry name" value="FIDO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13504">
        <property type="entry name" value="FIDO DOMAIN-CONTAINING PROTEIN DDB_G0283145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02661">
        <property type="entry name" value="Fic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140931">
        <property type="entry name" value="Fic-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51459">
        <property type="entry name" value="FIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fido" evidence="1">
        <location>
            <begin position="139"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="298" mass="34491" checksum="EB09A275A74A6B81" modified="2014-10-29" version="1">MSKRQQYLRKLYQVSHERISVRPKDFKKKMNELDGSESSILEYDGLLGKIKDGYSQWKASLSSSQWEKETQSFSVRFAFDTNKTQRELSLAATKRLLREGKAPKGRPFWQWGITPLQDLGEAEAQLELFTEILRSKNDLSLQTILRWHDKIFSATKPSIAGKIRKHQSTISGSRFTPPSPLELSALMRDLFAWYKTSKGKIHPVELAALMHLKLVSAHPFVDGNGRIARLAMNFILFRNGYPMFKIPYEWVDGYYRAIEESQVNNCQEAFLAWFARAYVIVNARYSTSELPKRSQKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MN45</accession>
    <name>A0A075MN45_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phage baseplate assembly protein W</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699517.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MN45"/>
    <dbReference type="STRING" id="1459636.NTE_00489"/>
    <dbReference type="GeneID" id="41596362"/>
    <dbReference type="KEGG" id="nev:NTE_00489"/>
    <dbReference type="HOGENOM" id="CLU_133204_0_2_2"/>
    <dbReference type="OrthoDB" id="147169at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007048">
        <property type="entry name" value="IraD/Gp25-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04965">
        <property type="entry name" value="GPW_gp25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160719">
        <property type="entry name" value="gpW/gp25-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IraD/Gp25-like" evidence="1">
        <location>
            <begin position="31"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="128" mass="14324" checksum="AAEE300CCB7070E7" modified="2014-10-29" version="1">MTVPTSANRAYYNRYPFNVDGRGRTASATSTDYIKQLVEQVLFTAVGERVNRPTFGSGVNQLVFSPNSNELASATQLLVHGALQQWLGDLIHVESVVVRNEDSSLHVVVHYIIKRSQQRQSAEFTRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MN98</accession>
    <name>A0A075MN98_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator with CheY-like receiver, AAA-type ATPase, and DNA-binding domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_00195</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MN98"/>
    <dbReference type="STRING" id="1459636.NTE_00195"/>
    <dbReference type="KEGG" id="nev:NTE_00195"/>
    <dbReference type="eggNOG" id="arCOG02595">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_8_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00156">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050595">
        <property type="entry name" value="Bact_response_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44591">
        <property type="entry name" value="STRESS RESPONSE REGULATOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44591:SF21">
        <property type="entry name" value="TWO-COMPONENT RESPONSE REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="16"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF82277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="156" mass="18159" checksum="4609F66E3E0F5641" modified="2014-10-29" version="1">MVTRAPRRTAFQGRPRLLVVDDEEDILDVIEEMLKSNNPPIQVDTFTDPERALKHFRDKREGYYSVVLSDVRMPRMSGFVFAREIRNLSHKVKIIMMSAFEMNKNEFDSVWPMLHISEFVSKPFTRDQLVRAVTKYMDMGDTSATAGKDDESMYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNF5</accession>
    <name>A0A075MNF5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">PMT family glycosyltransferase, 4-amino-4-deoxy-L-arabinose transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NTE_00663</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699652.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNF5"/>
    <dbReference type="GeneID" id="41596523"/>
    <dbReference type="KEGG" id="nev:NTE_00663"/>
    <dbReference type="HOGENOM" id="CLU_688114_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016763">
        <property type="term" value="F:pentosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050297">
        <property type="entry name" value="LipidA_mod_glycosyltrf_83"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038731">
        <property type="entry name" value="RgtA/B/C-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33908">
        <property type="entry name" value="MANNOSYLTRANSFERASE YKCB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33908:SF11">
        <property type="entry name" value="MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13231">
        <property type="entry name" value="PMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="39"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="218"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="283"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="313"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="337"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase RgtA/B/C/D-like" evidence="10">
        <location>
            <begin position="90"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="371"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="371"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIF82743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="400" mass="44149" checksum="BCA1D10F4D254E01" modified="2014-10-29" version="1">MAVNNDDGSRNDNSFTSISGKGAGGRHFGKLPAMSKIDIACIALMGLLVAYYFFYASTVIATPIWDGAVYLLNARGWLSGDNVPLYEGFRPPLLSWIIAGIWTIAGTENFEIIKYIQPLFTVGAGFVLYALLGRHKGKLFAFGVVALTMLNATLFFNSSQILTEGLSLFFLVTTLYLLAGKRGASEEKESGQKIIAFGEGWRWFFAGIAIALTFASRYPIIVPAVAIFIVASILRKDIRLAARTIIGAVPTFALIVLAVYLRTGTFETALAKDTNLSLLLSPFYIANSINIWGLVFLLVPVAFIFRKTYTDKFNYLFIAWFLASLAFWSANTSNFDYRFTIQLTPAVYYLAVLAIEHIAKHHNTIIVTIRKDGSSSDGNDSRSNREKHPPSFRASAETKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNK6</accession>
    <name>A0A075MNK6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01068</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNK6"/>
    <dbReference type="KEGG" id="nev:NTE_01068"/>
    <dbReference type="HOGENOM" id="CLU_2565868_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="84" mass="8528" checksum="4D87ECD4DA602959" modified="2014-10-29" version="1">MLGVGAVIVAGLLLSISVGAYSRILAMNDENGLKPRCGRGGAGCSTAHVPPASSVHYPNLLIAGLLSGSFGIALLIVRRQEIEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNT7</accession>
    <name>A0A075MNT7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNT7"/>
    <dbReference type="STRING" id="1459636.NTE_00395"/>
    <dbReference type="KEGG" id="nev:NTE_00395"/>
    <dbReference type="eggNOG" id="arCOG06267">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1412304_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="192" mass="21189" checksum="2D893A3E2A7E2095" modified="2014-10-29" version="1">MDYKEKVIEEKQHRIVSPYSMLTLLVPIAGLIFALVYGNLLVLNYVHVITGGTWTGIDLFMGLVMSRVMKGLEPQARTQVIKKLVPVMLFLMPSLASVAITSGINMAGKLGLLTLESPTIIAAIVIVIILSVQGFGMMMPTEIRVYLELRKKEPDRNKIIKWGMRNVKLAGSQGVFQVALIFVMANLALGFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNW0</accession>
    <name>A0A075MNW0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L15e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_00747</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699720.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNW0"/>
    <dbReference type="STRING" id="1459636.NTE_00747"/>
    <dbReference type="GeneID" id="41596599"/>
    <dbReference type="KEGG" id="nev:NTE_00747"/>
    <dbReference type="eggNOG" id="arCOG04209">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080796_1_0_2"/>
    <dbReference type="OrthoDB" id="8183at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1120.10">
        <property type="entry name" value="Ribosomal protein l15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024794">
        <property type="entry name" value="Rbsml_eL15_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000439">
        <property type="entry name" value="Ribosomal_eL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020925">
        <property type="entry name" value="Ribosomal_eL15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003269">
        <property type="entry name" value="PRK04243.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847">
        <property type="entry name" value="RIBOSOMAL PROTEIN L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00827">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01384">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01194">
        <property type="entry name" value="RIBOSOMAL_L15E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF82825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="152" mass="17772" checksum="C7A47A2E82782B94" modified="2014-10-29" version="1">MRSYMAQTWTKMWKENSDELKSKAIAWRQEPTINRIDRPSRLDRARRLGYKAKQGIIVVRVRVGRGGMRKQRPVAGRRPKHIGVVHIKQGISMRKVAERRVSEKFPNLEVMGSYYLHKDGMNIWYEVIMADPAHPAISKDREMRGKLKAFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNW5</accession>
    <name>A0A075MNW5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1326 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699724.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNW5"/>
    <dbReference type="STRING" id="1459636.NTE_00752"/>
    <dbReference type="GeneID" id="41596604"/>
    <dbReference type="KEGG" id="nev:NTE_00752"/>
    <dbReference type="eggNOG" id="arCOG11393">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092801_0_0_2"/>
    <dbReference type="OrthoDB" id="6311at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009758">
        <property type="entry name" value="DUF1326"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014581">
        <property type="entry name" value="UCP033303"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07040">
        <property type="entry name" value="DUF1326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033303">
        <property type="entry name" value="UCP033303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="212" mass="23041" checksum="56654B03EFD9DFBD" modified="2014-10-29" version="1">MSEDTPKWKASGDWFDVCKCNIPCPCTFAQAPSYGDCEGILAYHIKNGHYGETPLDGLNVMMVGGFKGNIWAGEAKATMGFFFDERANEKQREALQMIFTGKAGGFMGELAKAFGEDRGTEFVPIKFEIANDLAYWSAEVPGKVVARGEALTGPMTPPGKRVQTLNAPGSETGPGTVATWGRAVADEVDAMGFKWDWKGRSSKHIPFDWTGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNX4</accession>
    <name>A0A075MNX4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00767</name>
    </gene>
    <organism evidence="1 2">
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
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    <dbReference type="KEGG" id="nev:NTE_00767"/>
    <dbReference type="eggNOG" id="arCOG08739">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1352149_0_0_2"/>
    <dbReference type="OrthoDB" id="8197at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="201" mass="22358" checksum="16D2F1045A3EB7E1" modified="2014-10-29" version="1">MATGKGEVVTGYVCTPHGKQTASLVEVWKKSANIVDMYFAAATFSDESVPYFPNKANNYVLASFASMAGVLDDIRGGGMDRLAFMFSLNSPLFDRIGDKLNYVSLYFTKYSSGDPAIADLANVIARRDRVKKASLAEMQLLTAEQPRFAFPYSKNLVILEVEGSETHQTDQKYCERTRRDVARKGILLNNLVSFSILEKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MP18</accession>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">NTE_00465</name>
    </gene>
    <organism evidence="2 3">
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        <lineage>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
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    <dbReference type="GeneID" id="41596340"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="214"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
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        <location>
            <begin position="285"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="354"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="461" mass="51318" checksum="0B82BE873A5F1A3F" modified="2014-10-29" version="1">MNPEKFSATRSLSGSQGNSSVHSILAVVFIAVLLMDSLLSDLSTFVNQSFSESARVTLFSAIAILAVIFGGRLVLSDTRKIRSEFSSNNILNFASRIMPFIQYSILALLIVITLQMIFTSQYYTYIMITLTGMSWAASIGFMLLMSYKLIQWYRVRRNLLVLLYFVSSALIASVLALGIVPQIVIMTQTSSFSVSSHSSETKPFQANPVDLTGLYVILSVVNWLVIPLSFIIWAATAVMLRHYANSFGPRKYWLMISLPLVSIIIGVTFFLIFQSSVTTVFDPNVIVYTMIAFGGILSEGFLLGFAFIKISKHHRGITQSRLSGYLLLSAKGVTILFVAFFANPSGGSYLPFGIISVSFLCYGTYLFFSGIYSCAITIAGDIRLRQTIRKSLLDESKLLDNIGLADLNHEVERVTTEIVKKHNQTVWQETGIDASIPENDMKDYVNEVAGEIEKIRQRRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MP51</accession>
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    </protein>
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        <name evidence="2" type="ORF">NTE_00912</name>
    </gene>
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        <lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1459636.NTE_00912"/>
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    </dbReference>
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        <location>
            <begin position="148"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="217" mass="24315" checksum="32F0C2AED2A29319" modified="2014-10-29" version="1">MCQRARSRAETVPRRCSDIVQKLDEATQLLSESGLAKGFEVESGQDYGAGPIDVVWKIPVHPSLPEIKCGFVLMGASEGGDQDTQDNQFSIRKVEEAAMRGLRSGMDKIYLVTENEEMAKSVSGQIEWLASHGSLLRLDSIALGISPPYHGPSTVTPSQKRVPKGEKIRKKAIRNREAKLNKYNRPKRKSSFQRQALRESRIDRNSRPKDQVPKRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MP64</accession>
    <name>A0A075MP64_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integrase SSV1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00922</name>
    </gene>
    <organism evidence="1 2">
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        <lineage>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
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    <dbReference type="KEGG" id="nev:NTE_00922"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="62" mass="7396" checksum="FDB9149C5EC1A8A9" modified="2014-10-29" version="1">MGYCRKIFSTYLRMNGIESELIDLLQGRIPKTVFARHYFRPDFDKNTERVRNLVEALMTQIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MP91</accession>
    <name>A0A075MP91_9ARCH</name>
    <protein>
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    <organism evidence="1 2">
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        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
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                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
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    </reference>
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    <dbReference type="KEGG" id="nev:NTE_00899"/>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="43" mass="4898" checksum="7A7BE141341AB587" modified="2014-10-29" version="1">MTILQCTACLKLNYDGLQLISCSLEKNEGQRNHQKAKSCLMRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPA8</accession>
    <name>A0A075MPA8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="1 2">
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPA8"/>
    <dbReference type="STRING" id="1459636.NTE_00546"/>
    <dbReference type="KEGG" id="nev:NTE_00546"/>
    <dbReference type="HOGENOM" id="CLU_2839202_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="65" mass="7504" checksum="BC1C1DC0937CDED3" modified="2014-10-29" version="1">MLLLLLLALAGQIPFLKFLDLIFLCFCVYNFINSELFRNTIIEPKKNLKLEGNQKISCLKCLILT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPB8</accession>
    <name>A0A075MPB8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA/RNA helicase, superfamily II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NTE_00914</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385073.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPB8"/>
    <dbReference type="STRING" id="1459636.NTE_00914"/>
    <dbReference type="GeneID" id="41596750"/>
    <dbReference type="KEGG" id="nev:NTE_00914"/>
    <dbReference type="eggNOG" id="arCOG00874">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_558539_0_0_2"/>
    <dbReference type="OrthoDB" id="8379at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140097">
        <property type="term" value="F:catalytic activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050615">
        <property type="entry name" value="ATP-dep_DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11274:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11274">
        <property type="entry name" value="RAD25/XP-B DNA REPAIR HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="97"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="345"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF82990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="488" mass="55719" checksum="825D74B924214706" modified="2014-10-29" version="1">MMKTKANDDGHPNLKTQKIIFTSAFDLLRNPLANDDAIIIKNENPQPPSDLCQEKEKKEGIGEFRRHHLLPSQYGGPAIKSLHFPFALKPDQIKAVEAWMANGQRGSLIYSSGTGKTEIAFECARQAADRSGKQHFRVLLILPRIVLIEQNYRRLVNYGISKEKIGRYFGEQKEIREITLSTYHSVANAFSLVRDADMIIFDEVHLASNTARAFSRIFDIVSKKENGNKALLGLTATIDEDDPRNFTILTVLPPVRKYLIKDAVLDGRLARPVIVPIRVTLTEREQKTYDACSDKIKRISSRFHRHDPQSMMKLLKAGGFPSWQARAWFLNVRKRKTLLASADNKLSRAAELIAEKQRNKQKVMVFSETLESVRKLKQMLKENEIDSMIIDSSMPSFKRQRILSQWGTKFYPLLSVHTLEIGYDVPEVDVEIILASTSNMNQVVQRIGRVIRKFRGKEHAFVYVVYVADTKDDYMFSTFKRAINSAAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPC4</accession>
    <name>A0A075MPC4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01333</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700179.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPC4"/>
    <dbReference type="GeneID" id="41597132"/>
    <dbReference type="KEGG" id="nev:NTE_01333"/>
    <dbReference type="eggNOG" id="arCOG08708">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058359_0_0_2"/>
    <dbReference type="OrthoDB" id="9068at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="288" mass="32357" checksum="DFA9A79C3C51958E" modified="2014-10-29" version="1">MRLPLKGTDYFSKEVNAAFENIQAEFLEAVKPAISMQKSHAMLGDGTVTQTDTFDPQNVQTFYQRLTNKMEGWLAGGISKSVTEDLHRLFCQFNKDVGNKYYISGYFGIQFHALPYYKADRRVIEIQKELAKIADDATALYGGIRESADKALAQELERRGMAGMDFEGLFSKMFEDEKLAEELDKKAASVKGQAEFQKMGERKNALFAELNDLMIELYQTSAVPIDYNRLMQGEEGACTYFDIELIKTSAKKAIRREAMFETGKIPKADADKVAGELANVAKALKKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPD4</accession>
    <name>A0A075MPD4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type antimicrobial peptide transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_00929</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699860.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPD4"/>
    <dbReference type="STRING" id="1459636.NTE_00929"/>
    <dbReference type="GeneID" id="41596764"/>
    <dbReference type="KEGG" id="nev:NTE_00929"/>
    <dbReference type="eggNOG" id="arCOG00922">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_2"/>
    <dbReference type="OrthoDB" id="31298at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098796">
        <property type="term" value="C:membrane protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000032">
        <property type="entry name" value="Export ABC transporter ATP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015854">
        <property type="entry name" value="ABC_transpr_LolD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24220:SF86">
        <property type="entry name" value="ABC TRANSPORTER ABCH.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24220">
        <property type="entry name" value="IMPORT ATP-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="22"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF83005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="246" mass="27012" checksum="1C2DE1938E6B84EC" modified="2014-10-29" version="1">MTKPESDKAQDITAVQTNDIALEARDLYKVFDSAAGKVVALKHATFTVHKGEFVAIVGPSGSGKSTLLNLLGALDRPTSGKVIINGVDIFSLDDQEIATMRNKLIGFIFQSYNLINRTTVLRNVELPAIVMEIDKEERRNRALKVLEVLGIKDKANFKPTNLSGGQQQRVAIARSLMNNPAILLADEPTGNLDTKTGNEVFALLKMLSHKFRMTIVMVTHNPELAAATDRAIYVRDGGIEKEVRNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPF8</accession>
    <name>A0A075MPF8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Copper-containing nitrite reductase</fullName>
            <ecNumber evidence="3">1.7.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">NTE_00596</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>nitric oxide + Fe(III)-[cytochrome c] + H2O = Fe(II)-[cytochrome c] + nitrite + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15233"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.7.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Cu(+)</name>
            <dbReference type="ChEBI" id="CHEBI:49552"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotrimer.</text>
    </comment>
    <dbReference type="EC" id="1.7.2.1" evidence="3"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987130.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPF8"/>
    <dbReference type="STRING" id="1459636.NTE_00596"/>
    <dbReference type="GeneID" id="41596459"/>
    <dbReference type="KEGG" id="nev:NTE_00596"/>
    <dbReference type="eggNOG" id="arCOG02926">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG03914">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032707_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050421">
        <property type="term" value="F:nitrite reductase (NO-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd13921">
        <property type="entry name" value="Amicyanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11024">
        <property type="entry name" value="CuRO_1_2DMCO_NIR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035668">
        <property type="entry name" value="Amicyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000923">
        <property type="entry name" value="BlueCu_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052721">
        <property type="entry name" value="ET_Amicyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001287">
        <property type="entry name" value="NO2-reductase_Cu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36507">
        <property type="entry name" value="BLL1555 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36507:SF1">
        <property type="entry name" value="BLL1555 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00127">
        <property type="entry name" value="Copper-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00695">
        <property type="entry name" value="CUNO2RDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 10" id="KW-0186">Copper</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="15">
        <location>
            <begin position="73"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="14">
        <location>
            <begin position="207"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Blue (type 1) copper" evidence="13">
        <location>
            <begin position="377"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="353"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="binding site" description="type 1 copper site" evidence="10">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="type 1 copper site" evidence="10">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="type 1 copper site" evidence="10">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="type 1 copper site" evidence="10">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="type 1 copper site" evidence="10">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="type 1 copper site" evidence="10">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="type 1 copper site" evidence="10">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601287-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AIF82677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="450" mass="49718" checksum="A7C9E659135F4F84" modified="2014-10-29" version="1">MPSENNNNNDGGKKLLAIAIVAAIASSIVAGSLFFLAPEGQALGEMDNNINNNDNDDNNSNNNKKEVTLVAEEAQIEIAPGERVKAWTYNGTVPGPTLRFTEGDNVTIHFINKTPLAHTLHLHGNHDDESDGVHPQVLPGQSYNYTFVADPAGALMYHCHAYPTSLHIRMGMYGALIIDPKDDDKPEPAREFVIVMGEFDPKDQESFVPKYYLVNGYADQYMGDNMLHAKQGELVRMYVINMGTTIPYSFHLHSTIFKAYPSGLWSNDPIDAQTVEIGPGNAAMVEARWKWPGTYLFHSHGLQEERGNMGEIMVEPSQGPYEAESMIGWQHEQIEKLQKPEVVEHTAVTNATVQASSHHGTGPQVAIAKGSWDNKQKQNYSPREMSVNAGLEVTWVNQDATVHTVTDRQGAFDSSLIGAGGSWTHKFDSAGKYDYYCALHPWMEGTLTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPH5</accession>
    <name>A0A075MPH5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00965</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699886.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPH5"/>
    <dbReference type="STRING" id="1459636.NTE_00965"/>
    <dbReference type="GeneID" id="41596795"/>
    <dbReference type="KEGG" id="nev:NTE_00965"/>
    <dbReference type="HOGENOM" id="CLU_177467_0_0_2"/>
    <dbReference type="OrthoDB" id="6388at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="81" mass="8910" checksum="B262922AE7B75A05" modified="2014-10-29" version="1">MYSVTIETTGVDAAEAKDWANELANVYADMAVSDVNVSGNKISFKAGMTGMDDTEPDDIKMKLDEYVTMHEAFGVKKIDIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPK4</accession>
    <name>A0A075MPK4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_01427</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transcriptional regulator TrmB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPK4"/>
    <dbReference type="STRING" id="1459636.NTE_01427"/>
    <dbReference type="KEGG" id="nev:NTE_01427"/>
    <dbReference type="eggNOG" id="arCOG02037">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_489695_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051797">
        <property type="entry name" value="TrmB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021586">
        <property type="entry name" value="Tscrpt_reg_TrmB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002831">
        <property type="entry name" value="Tscrpt_reg_TrmB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34293">
        <property type="entry name" value="HTH-TYPE TRANSCRIPTIONAL REGULATOR TRMBL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34293:SF1">
        <property type="entry name" value="HTH-TYPE TRANSCRIPTIONAL REGULATOR TRMBL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11495">
        <property type="entry name" value="Regulator_TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01978">
        <property type="entry name" value="TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription regulator TrmB N-terminal" evidence="2">
        <location>
            <begin position="24"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription regulator TrmB C-terminal" evidence="3">
        <location>
            <begin position="288"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF83491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="570" mass="62638" checksum="B00BBB89564ECB1D" modified="2014-10-29" version="1">MYEQLYINPRPFTAVTEDPLVADLKAFGLEEMEAQAYVRLARLGKARASSLSSALKINRTTTYRILERLKQAGIVETSMSRPVSFIAVEPKKALQLLIDRRKDELRAAEGRYSSILEQFTKFYVPSEEAIGAKFNILQGNEEIHRAVTRLAKDASKKMSMITSVRDLGKMYYSGAYEAIAAAAARGVKVEILTEVTDLQALDIVAKHDGFAEVRHRAESKMRMVLKDEEEALITVAAGGAEEEVALWTYSQSFASAMQSIATNEFHSGIELGAIATALKTGKPAESFRIITDEKEYTSNMMALLTSAKSELYIGFNLHPTFSTPAVLEVLKSLASRGVKVRVLSAPSSEEADIVRKLHGTIDFRISAFQTDVQVMIADGKEMLFSNAARAQGSKRPDINIRTNLAGMVSFMHNIVADIWLDSREYTLELETLQQSILLNRCAGAVRAMMQDHGIEIVLGNKILGKSGVLHKFDIISPSTKAEGGGGRIAVSFLAYSDPESTGTRLMESKIKLLDCEPIDLVIGMLQASNQGGENDGPVAKLARAVGLHIVQAGDPDRLAELVFHEIERRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPL9</accession>
    <name>A0A075MPL9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699976.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPL9"/>
    <dbReference type="STRING" id="1459636.NTE_01085"/>
    <dbReference type="GeneID" id="41596901"/>
    <dbReference type="KEGG" id="nev:NTE_01085"/>
    <dbReference type="HOGENOM" id="CLU_200883_0_0_2"/>
    <dbReference type="OrthoDB" id="379212at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="73" mass="7991" checksum="AF98C2E6019DCB04" modified="2014-10-29" version="1">MAKKKQQQPQEPKLEGNAIVSSAGKSISISGDDGGPVLAVTNEYGNSAVYRIEAHSFDSLWSQLWQFVKDSQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPQ0</accession>
    <name>A0A075MPQ0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPQ0"/>
    <dbReference type="STRING" id="1459636.NTE_01110"/>
    <dbReference type="KEGG" id="nev:NTE_01110"/>
    <dbReference type="HOGENOM" id="CLU_2216930_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="106" mass="12275" checksum="0A836350A8BF6181" modified="2014-10-29" version="1">MQFFLLKYLFTANAMNKVRRLEAIYNKDAIITVQMASSSEVEVESVKRQVDIYKQLAKCLDAQDLASYDKVKMYKQMRKQLHANMKRYSKEGKGDLARMISQSLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPQ1</accession>
    <name>A0A075MPQ1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Molecular chaperone (Small heat shock protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_01031</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699935.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPQ1"/>
    <dbReference type="STRING" id="1459636.NTE_01031"/>
    <dbReference type="GeneID" id="41596854"/>
    <dbReference type="KEGG" id="nev:NTE_01031"/>
    <dbReference type="eggNOG" id="arCOG01832">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046737_9_5_2"/>
    <dbReference type="OrthoDB" id="198277at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041799">
        <property type="entry name" value="Hsp14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="21"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF83105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="128" mass="14377" checksum="6C74DCBFF19A2AFB" modified="2014-10-29" version="1">MGIGRYVVREVAKELDHRSREFYEFVMPAIDMVEEGSDLVVMIDLPGFAKQDIALRIQRNILSITAKRAAPEETGTVYQRHRPLRIEKSIVLPITVKEGEKVVGTATYTDGVVTLRIPVPSKETIPIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPR2</accession>
    <name>A0A075MPR2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01488</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700301.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPR2"/>
    <dbReference type="STRING" id="1459636.NTE_01488"/>
    <dbReference type="GeneID" id="41597278"/>
    <dbReference type="KEGG" id="nev:NTE_01488"/>
    <dbReference type="HOGENOM" id="CLU_1727300_0_0_2"/>
    <dbReference type="OrthoDB" id="12220at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="163" mass="18150" checksum="711CFF3CB95E29EB" modified="2014-10-29" version="1">MRRTHDRRVETSRLDKRVEIPFRLRAASALGISIAADILDYVAAPIFAMPLIGDAADAFISVVLYSITRSKKAAAINALEFIPVIGDFVPVYTLSTLIWIYEESAKRKRPQVAVAAGEKVPARDAYAIQPATAMSKGEVDLKALTSRRYARWKRELKQNVQTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPY7</accession>
    <name>A0A075MPY7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Gluconolactonase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_01165</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700035.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPY7"/>
    <dbReference type="GeneID" id="41596977"/>
    <dbReference type="KEGG" id="nev:NTE_01165"/>
    <dbReference type="eggNOG" id="ENOG502N57Q">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031076_0_3_2"/>
    <dbReference type="OrthoDB" id="8589at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017996">
        <property type="entry name" value="MRJP/yellow-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10009:SF18">
        <property type="entry name" value="PROTEIN YELLOW-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10009">
        <property type="entry name" value="PROTEIN YELLOW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03022">
        <property type="entry name" value="MRJP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF83238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="391" mass="43160" checksum="BA54C774C9AE9065" modified="2014-10-29" version="1">MSENFGTGGQSATTTNHQVERPAGIISKQELPTDESFGALEPVAYFDGAMPTGVTVSQKGRIFVNFPRWGYDVPFTVAEIRGGKPVAYPDEAVNQSRLDDQAAAFISVQSVVIDPADRLWILDTGSPMFQPTKYGGPKLVCVDLATNRIIKKILFPQEVALPTTYLNDVRFDLRRGNEGMAFITDSADTGPNGIIVVDLEDGESWRRLHDHPSTKAEGLQGFLPIVEGRPFLEHQQDGSVKPGAGMGADGIAISADGTRLYYCPLGSRKLYSVMTEALADREVDDSVTDEGDKGGAADGLESDAAGYIYSTNYEHNAILRRRFPEGQWETVVHDARLRWPDTLSLATDGYLYVTANQLHRQARFHQGRDLRRKPYVLFRIHVNAQPVMLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPZ1</accession>
    <name>A0A075MPZ1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">6-pyruvoyl-tetrahydropterin synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_00856</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699802.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPZ1"/>
    <dbReference type="STRING" id="1459636.NTE_00856"/>
    <dbReference type="GeneID" id="41596699"/>
    <dbReference type="KEGG" id="nev:NTE_00856"/>
    <dbReference type="eggNOG" id="arCOG02172">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1010542_0_0_2"/>
    <dbReference type="OrthoDB" id="6529at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.10">
        <property type="entry name" value="6-pyruvoyl tetrahydropterin synthase/QueD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007115">
        <property type="entry name" value="6-PTP_synth/QueD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038418">
        <property type="entry name" value="6-PTP_synth/QueD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12589:SF7">
        <property type="entry name" value="6-PYRUVOYL TETRAHYDROBIOPTERIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12589">
        <property type="entry name" value="PYRUVOYL TETRAHYDROBIOPTERIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01242">
        <property type="entry name" value="PTPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55620">
        <property type="entry name" value="Tetrahydrobiopterin biosynthesis enzymes-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF82932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="278" mass="31641" checksum="2A1597EF4ECD21B4" modified="2014-10-29" version="1">MPTERVVLNSDLRYLDSKGNLMRTRAELSVARMLDFLGHDYKYDQPVTLPDGKVVRVDFVAGSRHIEVVDSEADAAKFRRIKEEMQVLDIVAIGHSKYSSKVDEIDSMFFYDESERTQTGSIFIEDPSLAFDYAHILPLVEKCSVLHGHTSTVMVEIIGSMKNNLVVDFGEAKRIIKDTINMIDHKFFINKKYLEKEDDTHYYVSFQGPRGYFNLQLPKMTTWLMPGEATVENLSTEIIRLLAPRMPPNVEALGVYIYEGVNKGAHIIAGVKKEEKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQ01</accession>
    <name>A0A075MQ01_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700049.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQ01"/>
    <dbReference type="STRING" id="1459636.NTE_01180"/>
    <dbReference type="GeneID" id="41596991"/>
    <dbReference type="KEGG" id="nev:NTE_01180"/>
    <dbReference type="HOGENOM" id="CLU_2152490_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="111" mass="11963" checksum="5B398D26D4921E7E" modified="2014-10-29" version="1">MASCLELATCDPSTFGGLFNFFTYPLEVIFGGFFVMIAWGIILMIIFLRTHNPMLTSFVGLFIASFFVGTATFATPATAGATNVAWLLVAISMGSVLYFLIRSKAQNPSGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQ12</accession>
    <name>A0A075MQ12_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding ferritin-like protein (Oxidative damage protectant)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_01122</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Dps family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700005.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQ12"/>
    <dbReference type="STRING" id="1459636.NTE_01122"/>
    <dbReference type="GeneID" id="41596936"/>
    <dbReference type="KEGG" id="nev:NTE_01122"/>
    <dbReference type="eggNOG" id="arCOG01101">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098183_2_1_2"/>
    <dbReference type="OrthoDB" id="8265at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016722">
        <property type="term" value="F:oxidoreductase activity, acting on metal ions"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01043">
        <property type="entry name" value="DPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002177">
        <property type="entry name" value="DPS_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023188">
        <property type="entry name" value="DPS_DNA-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42932:SF3">
        <property type="entry name" value="DNA PROTECTION DURING STARVATION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42932">
        <property type="entry name" value="GENERAL STRESS PROTEIN 20U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005900">
        <property type="entry name" value="Dps"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01346">
        <property type="entry name" value="HELNAPAPROT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00818">
        <property type="entry name" value="DPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin/DPS" evidence="3">
        <location>
            <begin position="33"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF83195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="176" mass="20468" checksum="F3887C0D6D57A9C4" modified="2014-10-29" version="1">MTKQSLEVSRLIHADKEPKIGIPEKDREGVIRILTELLCDEYVMSAKTKKYHWNVVGPDFSELHKFLEEQYEEVDEIVDLVAERIRSLGGQTIGTLTEFIQYTRLKEDPGSYPDAHTMLANLLDSHEATIRILRGNVDETDEKFHDMGTNDFLIGLMEKHEKMAWMLRSYMVEKPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQ16</accession>
    <name>A0A075MQ16_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH arsR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700061.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQ16"/>
    <dbReference type="STRING" id="1459636.NTE_01196"/>
    <dbReference type="GeneID" id="41597005"/>
    <dbReference type="KEGG" id="nev:NTE_01196"/>
    <dbReference type="eggNOG" id="arCOG04362">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062767_3_0_2"/>
    <dbReference type="OrthoDB" id="11410at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="3"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="271" mass="30892" checksum="5CC683A04A015347" modified="2014-10-29" version="1">MATEQQPTEGVGSLFFELAGDLRLSMLSRLNKKDYRLSQLASELDATMQEAHRNMTRLIESGLVSKGKEGELVLTAYGRTVVSLVPSYDFLYKNRDFFADHSLGDLPAKFVQRLGSFQGCEMVHGVMAILQRWKTLYSSSDTFIKEIMAQVPLDLIETISAKVDEGVKFSYIFASNAVVPKGRTQLLQKVGWRNFINKGLVERRMLPDVKVMAIFNEKQGCVMFPNQKGEPDLNVMFYGETAEFLEWCNDFFNYQWSRADAFDEGKLKREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQ45</accession>
    <name>A0A075MQ45_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01227</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700089.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQ45"/>
    <dbReference type="STRING" id="1459636.NTE_01227"/>
    <dbReference type="GeneID" id="41597035"/>
    <dbReference type="KEGG" id="nev:NTE_01227"/>
    <dbReference type="HOGENOM" id="CLU_1615234_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="164" mass="16977" checksum="D8DD5AA1E3CB8DD3" modified="2014-10-29" version="1">MSPKILMYAIGVLAIASIACLPSVPVSKALAQESTEDDDNNVAEGQTRVHLADGSLALESGQEEIVSLDTGSDATPVYVVGTAVVEGGMVSIKLTDANGSSLSADGPTQVAIYPKEDPWSNYDGDVKDVMIPIRAGMEQLVFSAPSGAATITFDFDIVQEEAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQ53</accession>
    <name>A0A075MQ53_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC-type transport system, involved in lipoprotein release, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NTE_00931</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ABC-4 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699862.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQ53"/>
    <dbReference type="STRING" id="1459636.NTE_00931"/>
    <dbReference type="GeneID" id="41596766"/>
    <dbReference type="KEGG" id="nev:NTE_00931"/>
    <dbReference type="eggNOG" id="arCOG02312">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_8_0_2"/>
    <dbReference type="OrthoDB" id="11469at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050250">
        <property type="entry name" value="Macrolide_Exporter_MacB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30572:SF4">
        <property type="entry name" value="ABC TRANSPORTER PERMEASE YTRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30572">
        <property type="entry name" value="MEMBRANE COMPONENT OF TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="296"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="340"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="396"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="MacB-like periplasmic core" evidence="9">
        <location>
            <begin position="21"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="ABC3 transporter permease C-terminal" evidence="8">
        <location>
            <begin position="299"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIF83007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="429" mass="44973" checksum="E825D1FB8C1E1A73" modified="2014-10-29" version="1">MKIDDIYYLSFEALRDRKVRSALTILMVVVGSSLMVALNGLTAGFGVFIEKQFSNLASNVLTLTNSGGGGNFGGGGGGGGVVISAGGQPQSSGTIVNFNAAVVTKVKTLPLVNDVIPTYQGRVTLESQGKSRGVSVFAIAPEKLTTIAPTIQYKEGAELKANDPTGMVVADLIANPEGQPTPFLVVGQTVKASYSFTDPYTGEDKQESRSFIIRGIMAQTGNPNIDRAIIISPEIANSLLHKNGRYDSLMVVVPSPDDVSTVQDEIRVIYGNGVGISTPQAVLQARQQFTSGFSSFILAIALVALVVGAVGIVTTLYTSVTERIREIGTIKAIGALNKDILLIFISEASIIGVMGATLGLVFGIATGSLLTGAFSFGPRPGGGQDISPVYLPTDLLYVWGLSVGLSLLAGIYPAWKASRLEPIVALRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQ60</accession>
    <name>A0A075MQ60_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">K+-transporting ATPase, c chain</fullName>
            <ecNumber evidence="12">3.6.3.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NTE_00941</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SR1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.12" evidence="12"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699869.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQ60"/>
    <dbReference type="STRING" id="1459636.NTE_00941"/>
    <dbReference type="GeneID" id="41596776"/>
    <dbReference type="KEGG" id="nev:NTE_00941"/>
    <dbReference type="eggNOG" id="arCOG04805">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077094_2_0_2"/>
    <dbReference type="OrthoDB" id="8035at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003820">
        <property type="entry name" value="KdpC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30042">
        <property type="entry name" value="POTASSIUM-TRANSPORTING ATPASE C CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30042:SF2">
        <property type="entry name" value="POTASSIUM-TRANSPORTING ATPASE KDPC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02669">
        <property type="entry name" value="KdpC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001296">
        <property type="entry name" value="K_ATPase_KdpC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIF83017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="160" mass="17406" checksum="8FB5A2B84ADFF505" modified="2014-10-29" version="1">MEIKSGTLKPAIRVIVLMLVVTGVAYPLALVAVGQSVLPFQSNGSILELNGKEVGSRLIAQEFSSPKFFHPRPAAETASGVDPHITPDDAYSQAKGVSRATGIPENYLVTMIELNIERNRSANLVAFAPEYVNVLELNIELARQYPDVYAELPGEGQRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQA4</accession>
    <name>A0A075MQA4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">4-hydroxybenzoate polyprenyltransferase-like prenyltransferase</fullName>
            <ecNumber evidence="6">2.5.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NTE_01304</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="6"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700156.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQA4"/>
    <dbReference type="STRING" id="1459636.NTE_01304"/>
    <dbReference type="GeneID" id="41597106"/>
    <dbReference type="KEGG" id="nev:NTE_01304"/>
    <dbReference type="eggNOG" id="arCOG00476">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_862226_0_0_2"/>
    <dbReference type="OrthoDB" id="11851at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050475">
        <property type="entry name" value="Prenyltransferase_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42723">
        <property type="entry name" value="CHLOROPHYLL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42723:SF1">
        <property type="entry name" value="CHLOROPHYLL SYNTHASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF83373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="322" mass="35389" checksum="A52F64C47E07ED23" modified="2014-10-29" version="1">MSEEADQYEKLELEQEKTTAAATTTTTAWEKNAKQQILLFLHYVKARSNVYIFAFATFVSFLIGSNGNYDALVGLRVAASCYFLALATYIYNDVTDFEVDRVNKTNRPSVTGNASRKQLSGLVFVLFGLSLALAASINIQTLLIALLCVALGATYSHPRFNLKERFPLKTVTTAAGAALSSLLGGAAATHISFPIVYAALSFFLFFFVLGPLGDIGDLKGDRAAGRRTFPIVLGTRKTLIIMFSVPVILFLLIITQQFYKVATFQNGSFGVYMIVGTCLVAMTMIVKISKKIEDVGWIRGRVRPVMRLLHALLQISTLFAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQB5</accession>
    <name>A0A075MQB5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NTE_01193</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S54 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700059.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQB5"/>
    <dbReference type="STRING" id="1459636.NTE_01193"/>
    <dbReference type="GeneID" id="41597003"/>
    <dbReference type="KEGG" id="nev:NTE_01193"/>
    <dbReference type="eggNOG" id="arCOG01768">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG01833">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_945332_0_0_2"/>
    <dbReference type="OrthoDB" id="26567at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050925">
        <property type="entry name" value="Rhomboid_protease_S54"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43731:SF14">
        <property type="entry name" value="PRESENILIN-ASSOCIATED RHOMBOID-LIKE PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43731">
        <property type="entry name" value="RHOMBOID PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="8">
        <location>
            <begin position="66"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF83265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="339" mass="36700" checksum="482BE27CA002BCE6" modified="2014-10-29" version="1">MFPIHDDTERIHGRPWLNYTLIGINIAVFIWQASVTSFFTDERAVTEMFLTYGTVPDRLFSEWPGSAFTVVTSMFMHGGIAHIIGNMVFLWVFGDNIEDKFGRVKYILLYIGWGFAAALLHSAVAVYTGDGGGVPAVGASGAISGVLGAYMVLFPRARIYTIITAFFIYTVRIPVLVYIPFWFALQLIFGIIGQFGPLGDSGVAYLAHVGGFIAGAATGLVGRGFILPKIASLAGKGTTYKPPVKKVRPKIEDVVNETPPEVIEGPSYYEIIAEIKGVADASAISATYEPDSKLVRISANGSRRYEMAAKLPDTATGATVESVQYLNGIARIRLAKTPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQC1</accession>
    <name>A0A075MQC1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Mg2+/Co2+ transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NTE_01330</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700176.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQC1"/>
    <dbReference type="STRING" id="1459636.NTE_01330"/>
    <dbReference type="GeneID" id="41597129"/>
    <dbReference type="KEGG" id="nev:NTE_01330"/>
    <dbReference type="eggNOG" id="arCOG02265">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007127_0_2_2"/>
    <dbReference type="OrthoDB" id="28779at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015087">
        <property type="term" value="F:cobalt ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12822">
        <property type="entry name" value="TmCorA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.20">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46494">
        <property type="entry name" value="CORA FAMILY METAL ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46494:SF1">
        <property type="entry name" value="CORA FAMILY METAL ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF83398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="311" mass="35618" checksum="467FACF623DC73B0" modified="2014-10-29" version="1">MLRQVENEGFLWVDISAPTRNDMRELGRRFSFHELNLADCLSKIQIPKIDRYKNHVFVILHFPAMTEERVPKPSQFAAFLGSGYLVTVHQEDLKTVADTFDACQRSQEVRKELMGRSAGYLYHSLVDALVDELLNNVRKIMGNMEDIEDAVFDERVAVAREISYLRREVTSLRRIAIPMRRTLAELVAKDIQRFSEEDLTLYYDDVQDHIDKVIETLEESKDTIEIFKDTDFMHSSDRSNKILAVLTIIFTLSMPASILGSFYGMNVPIPGGIEGGPWTFLGSYTSFAIIVLASSTSAAAMIVYFRRIRWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQF8</accession>
    <name>A0A075MQF8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Delta-aminolevulinic acid dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Porphobilinogen synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">NTE_01381</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2 5-aminolevulinate = porphobilinogen + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="4.2.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the ALAD family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.24" evidence="3"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700218.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQF8"/>
    <dbReference type="STRING" id="1459636.NTE_01381"/>
    <dbReference type="GeneID" id="41597177"/>
    <dbReference type="KEGG" id="nev:NTE_01381"/>
    <dbReference type="eggNOG" id="arCOG04300">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035731_0_0_2"/>
    <dbReference type="OrthoDB" id="8493at2157"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004655">
        <property type="term" value="F:porphobilinogen synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00384">
        <property type="entry name" value="ALAD_PBGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000019">
        <property type="entry name" value="Delta-aminolevulinic acid dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001731">
        <property type="entry name" value="ALAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006762">
        <property type="entry name" value="PRK09283.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458">
        <property type="entry name" value="DELTA-AMINOLEVULINIC ACID DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458:SF0">
        <property type="entry name" value="DELTA-AMINOLEVULINIC ACID DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00490">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001415">
        <property type="entry name" value="Porphbilin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00144">
        <property type="entry name" value="DALDHYDRTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01004">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="6 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="10">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="10">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AIF83448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="337" mass="36672" checksum="EE7F79D04F574C2D" modified="2014-10-29" version="1">MKTRKNSSNNNSGFPDVRLRRLRKTPAIRDLFQETHLSVKDLIAPIFVEEGLKKPQDIGSMPDIKRLPLSSLSKEVEELSDLGVRAIILFGLPAEKDDKGSQAFADKGIVQKSVEQVRKHFGDKIAVITDVCLCQYTSHGHCGIVIDGGKIDNDSSASTLGRVAVSQARAGADIVAPSAMMDGQVRAIRSALDDAGFSDTAIMSYSSKQASPLFAPFRDAAHSAPEFGDRKTYQMPFTNPRESMREIEQDISEGVDAIIIKPAIPNLDLIYQASEATSLPICAYSVSGEYALIKAAAMEGWIDENAVMTEFLTGIKRAGADMIITYQAKKMAKLLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQM3</accession>
    <name>A0A075MQM3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative RNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699983.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQM3"/>
    <dbReference type="STRING" id="1459636.NTE_01094"/>
    <dbReference type="GeneID" id="41596910"/>
    <dbReference type="KEGG" id="nev:NTE_01094"/>
    <dbReference type="eggNOG" id="arCOG04130">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076814_1_0_2"/>
    <dbReference type="OrthoDB" id="7902at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.280">
        <property type="entry name" value="AF1531-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007003">
        <property type="entry name" value="DUF655"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40734:SF1">
        <property type="entry name" value="DNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40734">
        <property type="entry name" value="TRNA-SPECIFIC ADENOSINE DEAMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04919">
        <property type="entry name" value="DUF655"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160975">
        <property type="entry name" value="AF1531-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="205" mass="23184" checksum="691E9354B9E69A29" modified="2014-10-29" version="1">MSAAQDPAAGQQPPARAEAGHDHGQRKYEEYAYVLDYTPRGKSATVRGREGVIVQAIGEERLTLLELLGVQNSTFEVGERLYIGREGRNKIMSVLGRLDYNDVSQSAKNELPAIVEKVVLANEKRFVDYINMSQPITPRIHALELIPGIGKTYMMTIIKEREKKRFESFADLQNRVGLREPAKLVAKRIIEEIMGQARMNLFVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQN6</accession>
    <name>A0A075MQN6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Na+/melibiose symporter-like transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_01332</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700178.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQN6"/>
    <dbReference type="STRING" id="1459636.NTE_01332"/>
    <dbReference type="GeneID" id="41597131"/>
    <dbReference type="KEGG" id="nev:NTE_01332"/>
    <dbReference type="eggNOG" id="arCOG00130">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040020_1_0_2"/>
    <dbReference type="OrthoDB" id="117970at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17370">
        <property type="entry name" value="MFS_MJ1317_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23518">
        <property type="entry name" value="C-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23518:SF2">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="307"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="370"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="2">
        <location>
            <begin position="14"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF83400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="396" mass="41406" checksum="18B22C87D2C4BA71" modified="2014-10-29" version="1">MVEEGEKEKAGRKNVYALGFVSFFTDVSSEMVFALLPLFLTGPLGASRTLLGLIEGVGEMLGYTVRMGSGVLSDRAQRRKPLVTLGYSLSAASKPFFGAAAGWADAFAVRSLDRIGKGVRTAPRDALISESAPEAKVGRAFGIHRSMDQAGAIVGPALAFALFPYIGFQGVFYASILPGALAIAVLVLFVKERLAPLPSSSKAQSVSANVRAVLSQKRFVALLAIMAVFGVGAFNFSFVLVRASDLGVPESAVALVYLAINAAHTAVGYPAGALADRAGKEKMLVLAYGMFAASAFLMLASANVTQAYMLAIVYGAYVGIAETVQRAVVPRYVVSSEHRGTAYGLYNLVAGFSFLAANVVFGFLLDSSGIAAAATYSIITSALAAAAMMAFIIIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQP8</accession>
    <name>A0A075MQP8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01114</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQP8"/>
    <dbReference type="STRING" id="1459636.NTE_01114"/>
    <dbReference type="KEGG" id="nev:NTE_01114"/>
    <dbReference type="HOGENOM" id="CLU_2447517_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="89" mass="9694" checksum="D09EE5CE1122F2B6" modified="2014-10-29" version="1">MPVSAPASDAIEGTSWLLAAILIGGARSLPPIFRAYAFNNARKTPVVFFCPRPEGLLVALINSRQKTLTIFVPFHRLQARAINSLSTLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MR10</accession>
    <name>A0A075MR10_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NTE_01927</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700649.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MR10"/>
    <dbReference type="STRING" id="1459636.NTE_01927"/>
    <dbReference type="GeneID" id="41597675"/>
    <dbReference type="KEGG" id="nev:NTE_01927"/>
    <dbReference type="eggNOG" id="arCOG02358">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_481147_0_0_2"/>
    <dbReference type="OrthoDB" id="8127at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000001">
        <property type="entry name" value="Two-component sensor histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033425">
        <property type="entry name" value="MASE3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047:SF72">
        <property type="entry name" value="OSMOSENSING HISTIDINE PROTEIN KINASE SLN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17159">
        <property type="entry name" value="MASE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="241"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="354"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF83986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="578" mass="64013" checksum="D5F7AFD5DBA08C11" modified="2014-10-29" version="1">MANTTKSFISDGATSKEDQASLLTTLVKYTIVPSIPLVAIAIVSANLNLWVGNDTHHFYFELFAVVFAAIVAIYGLLRAYQTKDRFSLLIGLAYLTSAVIDALHASLSYNAANETLFLGYFIPQTWFAGRTFISSVMVIAILKYAVPPPVKTTLASSSSMPLADKEDVVLHEEKPDHYGYATNVVPSQQSSSVARRGGLLDKPLVSLSIIILTIVIATFLTVVSFFTVLPSIVINFPIHRPYELPPLILFSLALFFFYKKRVYRINDVFYKGILASLMLDVYSQIIMSYSANPFDTAHNVSHILKDASYFTNIISLALSSIQYNKIVKQNEQLIRASYERLKAADKIKDDFINIAAHELRTPLQPIISYSDLALNGVTDKEEALKVIDRQAKRLQKLSSDILDVSRIESGNLSYVIEKVRINEVIQEAANSQRLGLQDVEMQTRFATAPNMTIEADRGRIMQVLTNIISNAAKFTKQGFIRIETRSFAELNRLDIIISDTGPGIPAEILPNLFGKFVTKSTGTENYYGTGLGLFISKAIVSAHNGRISAHNGEAGGAVFEISLPITQDEKMKNRIAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MR83</accession>
    <name>A0A075MR83_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01642</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700427.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MR83"/>
    <dbReference type="GeneID" id="41597418"/>
    <dbReference type="KEGG" id="nev:NTE_01642"/>
    <dbReference type="eggNOG" id="arCOG08666">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_159744_0_0_2"/>
    <dbReference type="OrthoDB" id="8973at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="102" mass="11049" checksum="2E584E5B7357CA38" modified="2014-10-29" version="1">MLLPESCSVKVDGTECRLPPSYVVSIKSHDGEYMVAVVCDDHKDGLEHKLASMQKAGKAPAGKIHFQTVKAVVTDCVAGMEEDYVEIELKRGVSSDRKNLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRC3</accession>
    <name>A0A075MRC3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">L-2-aminoadipate N-acetyltransferase</fullName>
            <ecNumber evidence="12">6.3.2.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NTE_01582</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SR1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amino-acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RimK family. LysX subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.-" evidence="12"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700377.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRC3"/>
    <dbReference type="STRING" id="1459636.NTE_01582"/>
    <dbReference type="GeneID" id="41597362"/>
    <dbReference type="KEGG" id="nev:NTE_01582"/>
    <dbReference type="eggNOG" id="arCOG01589">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054353_2_1_2"/>
    <dbReference type="OrthoDB" id="33241at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043774">
        <property type="term" value="F:coenzyme F420-2 alpha-glutamyl ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009085">
        <property type="term" value="P:lysine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000025">
        <property type="entry name" value="Alpha-aminoadipate--LysW ligase LysX protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000058">
        <property type="entry name" value="Alpha-aminoadipate--LysW ligase LysX protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013651">
        <property type="entry name" value="ATP-grasp_RimK-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054562">
        <property type="entry name" value="LysX/ArgX_preATP_grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011870">
        <property type="entry name" value="LysX_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004666">
        <property type="entry name" value="Rp_bS6_RimK/Lys_biosynth_LsyX"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02144">
        <property type="entry name" value="LysX_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00768">
        <property type="entry name" value="rimK_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21621:SF2">
        <property type="entry name" value="COENZYME GAMMA-F420-2:ALPHA-L-GLUTAMATE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21621">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 MODIFICATION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22626">
        <property type="entry name" value="LysX_preATP_grasp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08443">
        <property type="entry name" value="RimK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP-grasp" evidence="11">
        <location>
            <begin position="102"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIF83645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="293" mass="32245" checksum="AAD73485C3812C0C" modified="2014-10-29" version="1">MSAGNGNSNTLTILYDTIRWEEKSLIEAAKKKGVETENIDVKNLTIRLDEESKKKYAGRTVLQRSVSYFKSLHATAALEGLGASVINPLRVASITGNKLFAHMEFQKAGVNTPKAIAAFSEESAAAALEEFGYPAVIKPTVGSWGRMIGLLRDRDAARAVIEDREHMFPLYHIYYFEEFVKRPPRDIRAIVVGDHVVAAIYRYSGDGEWKTNMALGGRAEVCPVTKELEDICMKATRAVGGQIVGVDLMESDSDGLMVHEVNNTTEFKNTVRVTGVDIPGQMVDYALALNKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRF9</accession>
    <name>A0A075MRF9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Flap endonuclease 1</fullName>
            <shortName evidence="11">FEN-1</shortName>
            <ecNumber evidence="11">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Flap structure-specific endonuclease 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">fen</name>
        <name evidence="15" type="ORF">NTE_01612</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.</text>
    </comment>
    <comment type="function">
        <text evidence="11">Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="11"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRF9"/>
    <dbReference type="STRING" id="1459636.NTE_01612"/>
    <dbReference type="KEGG" id="nev:NTE_01612"/>
    <dbReference type="eggNOG" id="arCOG04050">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032444_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09903">
        <property type="entry name" value="H3TH_FEN1-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09867">
        <property type="entry name" value="PIN_FEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000016">
        <property type="entry name" value="Flap endonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00614">
        <property type="entry name" value="Fen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002421">
        <property type="entry name" value="5-3_exonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023426">
        <property type="entry name" value="Flap_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019973">
        <property type="entry name" value="Flap_endonuc_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03674">
        <property type="entry name" value="fen_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF9">
        <property type="entry name" value="FLAP ENDONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00475">
        <property type="entry name" value="53EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 11 15" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 11" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6 11 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 11" id="KW-0540">Nuclease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="14">
        <location>
            <begin position="29"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="5'-3' exonuclease" evidence="12">
        <location>
            <begin position="49"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="13">
        <location>
            <begin position="168"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AIF83675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="369" mass="40879" checksum="9E5BCBB3352838FC" modified="2014-10-29" version="1">MDQLTAGQGSRVKKALNSYNFTHKKTQYMGLDLKPLITTVPIKLAELSGKVVAIDAFNTIYQFLSTIRGPTGELLMNGRGEVTSHLSGLFYRNINLLVENIKPVYVFDGKMHALKAQEIERRFKLKQEAVVQYNHALEEGRMEDAVKYGKRTSVLTDSMVEESKTLLTALGIPYVQAPADGEAAAAHLTKTGAAYASASQDYDSILFGAKRLVRNLAASGRRKVPGKSTYIDVEPEMVEHDNVLKETGLTHEQLVDVGILIGTDFNPSGFSGIGPKTAIKLIKENGRLENVDKIKGQLAEVPYQEIRDIFLKPEVPKADGVRFGEVNRERVLDFLCVQKSFSTDRVAGTLDKLQKAQESRSQSLEKWFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRG0</accession>
    <name>A0A075MRG0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRG0"/>
    <dbReference type="STRING" id="1459636.NTE_02080"/>
    <dbReference type="KEGG" id="nev:NTE_02080"/>
    <dbReference type="HOGENOM" id="CLU_1998651_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="124" mass="13741" checksum="7F9188DA32B52ED9" modified="2014-10-29" version="1">MLGCSVHTALMAHLEFSLYSMLSHFSLPPKYVTINETNRHLGNSNSTKTKTGHRVCVMCHDAISPASLSFEQRLVNDKDFCRKCWDEIITNTVYPGDERDDKPDDDNGVSSLVMAAMTTATKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRJ6</accession>
    <name>A0A075MRJ6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01369</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRJ6"/>
    <dbReference type="STRING" id="1459636.NTE_01369"/>
    <dbReference type="KEGG" id="nev:NTE_01369"/>
    <dbReference type="HOGENOM" id="CLU_2565542_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="81" mass="9300" checksum="83157D11B829E5A5" modified="2014-10-29" version="1">MFTAVNRRKHVTKTITARIPDEVHSEVLNRCNRAGVNINYFLNRALELVITGSSQFEFGDEEVEDDEGHQQRTLQKSLVIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRL5</accession>
    <name>A0A075MRL5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PEP phosphonomutase-like enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01742</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700505.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRL5"/>
    <dbReference type="STRING" id="1459636.NTE_01742"/>
    <dbReference type="GeneID" id="41597512"/>
    <dbReference type="KEGG" id="nev:NTE_01742"/>
    <dbReference type="eggNOG" id="arCOG00581">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027389_3_2_2"/>
    <dbReference type="OrthoDB" id="9667at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016833">
        <property type="term" value="F:oxo-acid-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000009">
        <property type="entry name" value="2-methylisocitrate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018523">
        <property type="entry name" value="Isocitrate_lyase_ph_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42905:SF5">
        <property type="entry name" value="CARBOXYVINYL-CARBOXYPHOSPHONATE PHOSPHORYLMUTASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42905">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13714">
        <property type="entry name" value="PEP_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00161">
        <property type="entry name" value="ISOCITRATE_LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="287" mass="32053" checksum="BEC3C72D9DB34D2F" modified="2014-10-29" version="1">MQKPRSLREQLEDKNRIIVLPGVFDALSARIAEQVGFEAMFQTGYGSSAALLGMPDFGFLNAGETVDNARRIIRAVSVPVLVDADTGYGNPLNVWRLVRDLEALGAAGIFLEDQIWPKRCGHMVGKDVIPKDDYLPKLKAAVEARKSRDFIIVARTDARAPLGLDEAIERGKAYRKAGADVIFVEAPRTVEELKKVADEIDAPLVANMIEDGVTPNLTGPELLKLGYRIAVWPLSGLYSATYAMREVFTELKKTSYTKKTRKMMVTFKDFNEFVDLQKYMGLEKRYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRP9</accession>
    <name>A0A075MRP9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Matrixin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NTE_01428</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRP9"/>
    <dbReference type="STRING" id="1459636.NTE_01428"/>
    <dbReference type="KEGG" id="nev:NTE_01428"/>
    <dbReference type="eggNOG" id="arCOG04994">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1248321_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001818">
        <property type="entry name" value="Pept_M10_metallopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021190">
        <property type="entry name" value="Pept_M10A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00413">
        <property type="entry name" value="Peptidase_M10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00138">
        <property type="entry name" value="MATRIXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M10 metallopeptidase" evidence="5">
        <location>
            <begin position="138"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF83492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="251" mass="26706" checksum="FFEA702F5E04D847" modified="2014-10-29" version="1">MTVLLAVSLSCVRLFVVIIPLLVMLPAAAAAAVVTVSTPPKTYESVEFLEGVAERTAVEDGGGSHYTIDTRAFWLDKPSLAVAVASSDGASDAAVQSVKDMISGKNITMLSGPYSQWNDLLSVFQQAAVPRLSLADEDASANIKVVLTDAAQQDNKPGKTRLLADKATGEIVQAEVYVYSADKLYGQGMLEYVVAHELGHALGLSHSTDPKSMMYPLMEVEDGHVVNQLGLCEIEGISALYLESRIGSENC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRS9</accession>
    <name>A0A075MRS9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH marR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_00035</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699185.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRS9"/>
    <dbReference type="STRING" id="1459636.NTE_00035"/>
    <dbReference type="GeneID" id="41595987"/>
    <dbReference type="KEGG" id="nev:NTE_00035"/>
    <dbReference type="eggNOG" id="arCOG03748">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120314_0_0_2"/>
    <dbReference type="OrthoDB" id="11852at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="HTH marR-type" evidence="3">
        <location>
            <begin position="9"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF82119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="199" mass="20929" checksum="51C24CA071F6AE9A" modified="2014-10-29" version="1">MSSSSVNESPNHFMVLDAISRGVKSVGKIAKVTKLDKALVEMIVNDLAAQRLIIKSEKKGFFGGKKEELTVTETGMRVLAAKKQELERKFQEFQQWYSNGQTQQLQNSMQNDRMWLPFMLFSGIMNAMFFMSMMSFMGAALTPTETALAGDQGVDTGAGGADAGTDGGGAGADGGGGGMDSGGGGDFGGGDFGGGDFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MS35</accession>
    <name>A0A075MS35_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Putative 3-methyladenine DNA glycosylase</fullName>
            <ecNumber evidence="5">3.2.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NTE_01559</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the DNA glycosylase MPG family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="5"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700360.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MS35"/>
    <dbReference type="STRING" id="1459636.NTE_01559"/>
    <dbReference type="GeneID" id="41597341"/>
    <dbReference type="KEGG" id="nev:NTE_01559"/>
    <dbReference type="eggNOG" id="arCOG04295">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060471_4_1_2"/>
    <dbReference type="OrthoDB" id="31217at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003905">
        <property type="term" value="F:alkylbase DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00540">
        <property type="entry name" value="AAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.300.10:FF:000001">
        <property type="entry name" value="Putative 3-methyladenine DNA glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.300.10">
        <property type="entry name" value="Methylpurine-DNA glycosylase (MPG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00527">
        <property type="entry name" value="3MGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011034">
        <property type="entry name" value="Formyl_transferase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003180">
        <property type="entry name" value="MPG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036995">
        <property type="entry name" value="MPG_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00567">
        <property type="entry name" value="3mg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002003">
        <property type="entry name" value="PRK00802.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10429">
        <property type="entry name" value="DNA-3-METHYLADENINE GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10429:SF0">
        <property type="entry name" value="DNA-3-METHYLADENINE GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02245">
        <property type="entry name" value="Pur_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50486">
        <property type="entry name" value="FMT C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF83622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="207" mass="22906" checksum="7A6A58FDA19CFD9F" modified="2014-10-29" version="1">MLTLARSFYQRPTTEVARDLIGKVLVRRLDDDGGRSNRLSGIIVETEAYGHAEDPASHACRGMTERNRVMFGEAGMAYVYFTYGNHHCINVSARNGAPAGAVLIRSIEPVDGIKEMRRRRGLDDPYLLTTGPGRLAQAMNITRRQNGVDMTDPESEITIEDGPARETVMATARIGISKATDVQWRFVDPASAFLSRKRARPASLQVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MS46</accession>
    <name>A0A075MS46_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">50S ribosomal protein L40e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_01569</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700366.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MS46"/>
    <dbReference type="STRING" id="1459636.NTE_01569"/>
    <dbReference type="GeneID" id="41597349"/>
    <dbReference type="KEGG" id="nev:NTE_01569"/>
    <dbReference type="eggNOG" id="arCOG04049">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_175093_1_0_2"/>
    <dbReference type="OrthoDB" id="45138at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023657">
        <property type="entry name" value="Ribosomal_eL40_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001975">
        <property type="entry name" value="Ribosomal_eL40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038587">
        <property type="entry name" value="Ribosomal_eL40_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003161">
        <property type="entry name" value="PRK04136.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39649">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L40E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39649:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01377">
        <property type="entry name" value="Ribosomal_L40e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL40" evidence="4">
        <location>
            <begin position="3"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF83632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="55" mass="6483" checksum="F91B54236CB24C91" modified="2014-10-29" version="1">MPITDATKKQIAQQRRLYFKICFRCGSKNHIDAVRCRKCHSHHMRAKNRTLGAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSF9</accession>
    <name>A0A075MSF9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoside-diphosphate-sugar pyrophosphorylase family protein</fullName>
            <ecNumber evidence="2">2.7.7.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.13" evidence="2"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700737.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSF9"/>
    <dbReference type="STRING" id="1459636.NTE_02041"/>
    <dbReference type="GeneID" id="41597781"/>
    <dbReference type="KEGG" id="nev:NTE_02041"/>
    <dbReference type="eggNOG" id="arCOG00663">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029499_2_0_2"/>
    <dbReference type="OrthoDB" id="15372at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004475">
        <property type="term" value="F:mannose-1-phosphate guanylyltransferase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd04181">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050486">
        <property type="entry name" value="Mannose-1P_guanyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22572">
        <property type="entry name" value="SUGAR-1-PHOSPHATE GUANYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="235" mass="26411" checksum="8C4CCEEC608DB223" modified="2014-10-29" version="1">MKAVILAGGLGTRLQPYTFFIPKPMLPLGNKPLLEYTIEWLRNAGGIKEIVICVSYLHRTIEDYFEDGSRFNVNIDYARAERPLATAGQLKTAEKMLADDTFVCVYGDSVYEFNLRKMLKMHKESNAFISMALMHYSTKLKYGFIDVEGNDITGWREKPEISGLINIGCYVMEPSFLKAIPKAGAFGMDDAVRNALAQKKKVKAFEVDGSGFIDIGDKKSYLDAYKQFASRLGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSI8</accession>
    <name>A0A075MSI8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heme/copper-type cytochrome/quinol oxidases, subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700469.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSI8"/>
    <dbReference type="STRING" id="1459636.NTE_01696"/>
    <dbReference type="GeneID" id="41597466"/>
    <dbReference type="KEGG" id="nev:NTE_01696"/>
    <dbReference type="eggNOG" id="arCOG02926">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1933325_0_0_2"/>
    <dbReference type="OrthoDB" id="8698at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028096">
        <property type="entry name" value="EfeO_Cupredoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13473">
        <property type="entry name" value="Cupredoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EfeO-type cupredoxin-like" evidence="1">
        <location>
            <begin position="57"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="139" mass="15021" checksum="ABE3B6D6B7183B2C" modified="2014-10-29" version="1">MSVRNNVIAIVAISCIVVGGLWAVGNLTKETKEADVSHVEGILLLAERSTFNSTNPDISVQVDVPKKLVVLNKDIVIHDLQIKDNSGGILNFETAPLKTEQHFNAAIVAYKPGTYEYFCSYHPTMRGKIIATPAPASAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSU2</accession>
    <name>A0A075MSU2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02603</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701180.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSU2"/>
    <dbReference type="STRING" id="1459636.NTE_02603"/>
    <dbReference type="GeneID" id="41598296"/>
    <dbReference type="KEGG" id="nev:NTE_02603"/>
    <dbReference type="eggNOG" id="arCOG03547">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG08642">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_788981_0_0_2"/>
    <dbReference type="OrthoDB" id="11329at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047676">
        <property type="entry name" value="FxLYD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF038353">
        <property type="entry name" value="FxLYD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="357" mass="37988" checksum="A550DC9180A17186" modified="2014-10-29" version="1">MAIKAAFVAALVAGAMIMIAVSPPPLLLSASAQSLEDRLYFYPQVPTEKSPVTAKVSLTTPTPCYKVEMQDFEKSGNVISINVKVTPPAQDTVCAQVLKSHLLEQDIGTLKAGAYTARLYVNGEEKATTRLYVTERDVAVLSAGTYVDYQGDANLIGEVQNTGSAPLERVAVDINFFQGDSLFQEERVYTTMGTLMPNMTSGFSLLLGGNGDLRNKEYSVRVTAYDNAPAKQHALQLVVEPEPGNGVISGTVYNNSIERNATQVKIACVVYDAQGSAVDSVFDYSKPGTIAPGKSAGFTIQSNHDVGNNFTASCNSESVEFATGAVQVVPEFPAATLALAGSLAGLAILAHRFRDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSZ1</accession>
    <name>A0A075MSZ1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SUF system FeS assembly protein, NifU family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02653</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701221.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSZ1"/>
    <dbReference type="STRING" id="1459636.NTE_02653"/>
    <dbReference type="GeneID" id="41598345"/>
    <dbReference type="KEGG" id="nev:NTE_02653"/>
    <dbReference type="eggNOG" id="arCOG02077">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079283_4_0_2"/>
    <dbReference type="OrthoDB" id="319865at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06664">
        <property type="entry name" value="IscU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002871">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01994">
        <property type="entry name" value="SUF_scaf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10093">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY ENZYME NIFU HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01592">
        <property type="entry name" value="NifU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82649">
        <property type="entry name" value="SufE/NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NIF system FeS cluster assembly NifU N-terminal" evidence="1">
        <location>
            <begin position="6"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="142" mass="15875" checksum="5D6C6B78EA758F11" modified="2014-10-29" version="1">MSDDIYREIILDHYRNPRNKGKIQNADVSIHDSNPLCGDEIDIHLKVDGDKIKDIKFEGRGCAISQASASMLTEMVMNKQLASVKDLTKDDILENIGLMNLGPARIKCALLSLKVLKLGMVKYYADRDPASAKKLQDDTRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MT43</accession>
    <name>A0A075MT43_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tryptophan synthase beta chain</fullName>
            <ecNumber evidence="12">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">trpB</name>
        <name evidence="14" type="ORF">NTE_01913</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 12">The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + L-tryptophan + H2O</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 12">Tetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the TrpB family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="12"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700639.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MT43"/>
    <dbReference type="STRING" id="1459636.NTE_01913"/>
    <dbReference type="GeneID" id="41597662"/>
    <dbReference type="KEGG" id="nev:NTE_01913"/>
    <dbReference type="eggNOG" id="arCOG01433">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016734_3_1_2"/>
    <dbReference type="OrthoDB" id="371827at2157"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06446">
        <property type="entry name" value="Trp-synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000001">
        <property type="entry name" value="Tryptophan synthase beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000004">
        <property type="entry name" value="Tryptophan synthase beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00133">
        <property type="entry name" value="Trp_synth_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006653">
        <property type="entry name" value="Trp_synth_b_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006654">
        <property type="entry name" value="Trp_synth_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023026">
        <property type="entry name" value="Trp_synth_beta/beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00263">
        <property type="entry name" value="trpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48077:SF3">
        <property type="entry name" value="TRYPTOPHAN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48077">
        <property type="entry name" value="TRYPTOPHAN SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001413">
        <property type="entry name" value="Trp_syn_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00168">
        <property type="entry name" value="TRP_SYNTHASE_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="10 12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 12" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="13">
        <location>
            <begin position="54"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="12">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AIF83972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="406" mass="44190" checksum="47C404117D08457A" modified="2014-10-29" version="1">MLGSYPVGGKFGKYGGKFIPETLEPAVRELESAYEKYRNDLDFQKELHYYLTQYAGRPTPLYFAKNLTEYAGGAKILLKREDLLHGGAHKTNNTLGQGLLAKRMGKKRIIAETGAGQHGVGTALACAMLGLSAEVYMGSKDVERQKLNVFRMQLLGAKVHPVDSGTKTLKDAINEAIRDWISNVNSTYYLIGTVMGPHPYPMMVRDFQSVIGKEVKDEMQRQYGRLPSAIVACVGGGSNAMGSFYPFVDDSSVRLVGVEAAGEGIKSGKHAATLTAGTAGVLHGMFTYVLQDKDGQIMDTHSISAGLDYPGVGPEHSMLKDLNRAEYVPCTDGEAVEAFLTLSRLEGIIPALESSHAISHAVKMAKEMDKDEVIVVTLSGRGDKDVTVVQDYLNSKKGRRHHATRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MT91</accession>
    <name>A0A075MT91_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_02285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MT91"/>
    <dbReference type="STRING" id="1459636.NTE_02285"/>
    <dbReference type="KEGG" id="nev:NTE_02285"/>
    <dbReference type="eggNOG" id="arCOG01159">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_932556_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="229"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="22"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="233"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF84338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="298" mass="35340" checksum="CB5BE80EEE028EDA" modified="2014-10-29" version="1">MKTLLEFKKTVVDEQKQGDKKIEEINTRLEAVKKQIDEERMQLDELRAKLKGVNEEKDADYPKFVELRNSLIEAKNQMKSLDDKVGQAKSRKDRNEIHGLTKALEQIERDIQTKKLSKEEERKLVARSKEIATKLHTLKMMHKKEDQYREMSTQYDELKGRVNKIFRQKEEFGNKIGKLKESIESLVNTREALYEERRQVIHTVREAAAKLEMIETQLNAIAFKKNRMAQSETRQKKTKEMEERRVARQEAMQERVRRDKEYQERWNALKEAAMKKMSSGEKLTFDEMKLIFGDSAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTD5</accession>
    <name>A0A075MTD5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700954.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTD5"/>
    <dbReference type="GeneID" id="41598036"/>
    <dbReference type="KEGG" id="nev:NTE_02320"/>
    <dbReference type="eggNOG" id="arCOG00731">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1567059_0_0_2"/>
    <dbReference type="OrthoDB" id="9749at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="170" mass="18488" checksum="F4C2D6B02F0923CD" modified="2014-10-29" version="1">MSTNIAKAASVTIVLFTALTLTHAAFVDYRTSAGGGDKSLGQMPYLQNRKFGVEMSSLSFGRDSWRGQVRQKWTECGLCCGVYELLVRMKGGPTRARLLALLAAVPKNKLQLANESGIDWKAVDRHVERMLEFGLVQAVATAGTCTMYAITEKGSRALALVDCSNSCFKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTK3</accession>
    <name>A0A075MTK3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UDP-N-acetyl-D-mannosaminuronate dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.336</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_02391</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.336" evidence="3"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701014.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTK3"/>
    <dbReference type="STRING" id="1459636.NTE_02391"/>
    <dbReference type="GeneID" id="41598101"/>
    <dbReference type="KEGG" id="nev:NTE_02391"/>
    <dbReference type="eggNOG" id="arCOG00252">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069297_0_0_2"/>
    <dbReference type="OrthoDB" id="59839at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089714">
        <property type="term" value="F:UDP-N-acetyl-D-mannosamine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028359">
        <property type="entry name" value="UDP_ManNAc/GlcNAc_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43491">
        <property type="entry name" value="UDP-N-ACETYL-D-MANNOSAMINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43491:SF1">
        <property type="entry name" value="UDP-N-ACETYL-D-MANNOSAMINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500136">
        <property type="entry name" value="UDP_ManNAc_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDP-glucose/GDP-mannose dehydrogenase dimerisation" evidence="2">
        <location>
            <begin position="184"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF84443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="296" mass="32923" checksum="F0FE7EFEF1DF8A80" modified="2014-10-29" version="1">MHESNNNGHDKKILVIGLGQIGYSNAEYLRSLGGLRVDGFDISEKAVERAIKDGIIDKKAADFAGYDYYLICISTHQPNDMFTPYQDGIMEVAYRIATEGRQGALVGIDSTIPKGTSRKVLALLNHKMHVVHVPHRYYGPEKKEHGVNQTRVIGGCEPCCMAEGKKFYGQMLGIPLHEVSAIEVAEMTKIVENSYRFLEIAFAEELKMVSESAGIDFDELRKAVNTKWNIKILEAREGIGGHCLPKDTEMFLSVAKNALDSSIVSAAKMVDHKYRFYLSQKPIAPQVELGKAKTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTL9</accession>
    <name>A0A075MTL9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NTE_02423</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTL9"/>
    <dbReference type="STRING" id="1459636.NTE_02423"/>
    <dbReference type="KEGG" id="nev:NTE_02423"/>
    <dbReference type="HOGENOM" id="CLU_045498_5_5_2"/>
    <dbReference type="OrthoDB" id="380062at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051598">
        <property type="entry name" value="TSUP/Inactive_protease-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43701">
        <property type="entry name" value="MEMBRANE TRANSPORTER PROTEIN MJ0441-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43701:SF2">
        <property type="entry name" value="MEMBRANE TRANSPORTER PROTEIN YJNA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF84473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="186" mass="19289" checksum="20451C0CF43EC710" modified="2014-10-29" version="1">MRQNNLHRRVFAVMAVTGAAGAFAGSLFTRIVPAQGLLLLVGAIVSYEAFSLIKSLRHKGAENLRPNLAPESAIGLGVGFLGGLVGLVLGSIRLPAVINVLKMEPRVAVGTNLAASSAMGAAGLIGHAINGEVDYEVLAVMGATAMAGAFVGAKYTGRFDERTLKLLIGLILVAVAAVMFWRALYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTN6</accession>
    <name>A0A075MTN6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thiamine-monophosphate kinase</fullName>
            <shortName evidence="1">TMP kinase</shortName>
            <shortName evidence="1">Thiamine-phosphate kinase</shortName>
            <ecNumber evidence="1">2.7.4.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">thiL</name>
        <name evidence="4" type="ORF">NTE_02945</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>thiamine phosphate + ATP = thiamine diphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:15913"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine diphosphate from thiamine phosphate: step 1/1.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiamine-monophosphate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.16" evidence="1"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701461.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTN6"/>
    <dbReference type="STRING" id="1459636.NTE_02945"/>
    <dbReference type="GeneID" id="41598622"/>
    <dbReference type="KEGG" id="nev:NTE_02945"/>
    <dbReference type="eggNOG" id="arCOG00638">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046964_2_1_2"/>
    <dbReference type="OrthoDB" id="45909at2157"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00142"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009030">
        <property type="term" value="F:thiamine-phosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02194">
        <property type="entry name" value="ThiL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="entry name" value="PurM-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="entry name" value="PurM-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02128">
        <property type="entry name" value="TMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006283">
        <property type="entry name" value="ThiL-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01379">
        <property type="entry name" value="thiL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30270">
        <property type="entry name" value="THIAMINE-MONOPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30270:SF0">
        <property type="entry name" value="THIAMINE-MONOPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005303">
        <property type="entry name" value="Thiam_monoph_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="PurM C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="PurM N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PurM-like N-terminal" evidence="2">
        <location>
            <begin position="24"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="PurM-like C-terminal" evidence="3">
        <location>
            <begin position="148"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="115"/>
            <end position="116"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>5</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF84981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="317" mass="33351" checksum="4870E33F2498A99A" modified="2014-10-29" version="1">MTKQLDEKEIISIFSQALGIADLDDVAAIDGSRNLVFKADMLVASTDVPPQMRPWQVARKSIVSCASDLAAKGARPVAAMISLGLPAGITRTYVEELARGFQIASREFGVKIVGGDTNAARDLVIDCSMIGMMTMTVNDKMPKRSGAKPGDAVVASGKFGYPASGLAVLLRGARAQGAFRAAAVDSALEPKPRQAFGTALARYFSSSIDSSDGLAASLYEIAIQSGVDIKVDYDAARADGVQEFAGANNLDAHELVFHGGEEYEIVATMPKSLLPRAKAAAKKAGCDLHVIGCVIKGTGKVTAGERPLENRGYLHFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTP7</accession>
    <name>A0A075MTP7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701113.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTP7"/>
    <dbReference type="GeneID" id="41598215"/>
    <dbReference type="KEGG" id="nev:NTE_02511"/>
    <dbReference type="HOGENOM" id="CLU_209470_0_0_2"/>
    <dbReference type="OrthoDB" id="377225at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="60" mass="6522" checksum="E6E5768FB1CECCAE" modified="2014-10-29" version="1">MGLLKKLKNVAEQGVEKGAELGKKGIEKGAEVSTKAYDGAKEAAQKGYEKAREDKKKEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTR9</accession>
    <name>A0A075MTR9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02533</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701126.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTR9"/>
    <dbReference type="STRING" id="1459636.NTE_02533"/>
    <dbReference type="GeneID" id="41598232"/>
    <dbReference type="KEGG" id="nev:NTE_02533"/>
    <dbReference type="HOGENOM" id="CLU_2712614_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="72" mass="8077" checksum="0130B077702162C6" modified="2014-10-29" version="1">MPDKSVRAVNRLVPRLSRGAKAEVCKIAMNILDDVDRGIIRSTNLGDYNSIRNLSNEAIFIKALTADCNRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MU12</accession>
    <name>A0A075MU12_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00674</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MU12"/>
    <dbReference type="STRING" id="1459636.NTE_00674"/>
    <dbReference type="KEGG" id="nev:NTE_00674"/>
    <dbReference type="HOGENOM" id="CLU_3362468_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="35" mass="4117" checksum="82EDAE121C678DB8" modified="2014-10-29" version="1">MNRKIVIIAAIESWQLLLPLRLFYHCLLSLMQTMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MU50</accession>
    <name>A0A075MU50_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cysteine desulfurase</fullName>
            <ecNumber evidence="3">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NTE_02652</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(sulfur carrier)-H + L-cysteine = (sulfur carrier)-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="3"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MU50"/>
    <dbReference type="STRING" id="1459636.NTE_02652"/>
    <dbReference type="KEGG" id="nev:NTE_02652"/>
    <dbReference type="eggNOG" id="arCOG00065">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003433_2_5_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006534">
        <property type="term" value="P:cysteine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06453">
        <property type="entry name" value="SufS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010970">
        <property type="entry name" value="Cys_dSase_SufS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016454">
        <property type="entry name" value="Cysteine_dSase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01979">
        <property type="entry name" value="sufS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43586">
        <property type="entry name" value="CYSTEINE DESULFURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43586:SF8">
        <property type="entry name" value="CYSTEINE DESULFURASE 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005572">
        <property type="entry name" value="NifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="7">
        <location>
            <begin position="30"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF84695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="415" mass="46661" checksum="265AFB8B68CD59D4" modified="2014-10-29" version="1">MMQKGALNVEKIRKDFPILKRKVMGGKPLVYLDNAATTQKPLAVIDAIHDYYMNYNSNIHRAVHQLAEEATKAYEDTRVKIAKFINARSTDEIIFTRNTTEAINLVAYSWGRANIKKDDRIVITEIEHHSNIVPWQILTQEKGAKLEYIGVGDDGYLKMHEYKKYLDSGKVKLVSVSHMSNVLGTITPINDIINMAHEKGIPVLVDGAQSVPHMPVDVQKLDCEFMAFSAHKMLGPTGVGVLYVKRELLEKMPPFMGGGDMIKEVHKYETRYNDLPYKFEGGTPNIADVIGFAAAIDYLQKIGMDRVREHEIDITKYALDRVAQVKGVTIYGPMNAIDRGGVVSFNIGDIHPHDLATIMNDHGVAIRSGHHCAQVLMERLDVAATSRASFYIYNTKEEVDVFIDALSEARRLFKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MU69</accession>
    <name>A0A075MU69_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidase, Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit</fullName>
            <ecNumber evidence="2">6.3.5.6</ecNumber>
            <ecNumber evidence="2">6.3.5.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00791</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.3.5.6" evidence="2"/>
    <dbReference type="EC" id="6.3.5.7" evidence="2"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699754.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MU69"/>
    <dbReference type="STRING" id="1459636.NTE_00791"/>
    <dbReference type="GeneID" id="41596641"/>
    <dbReference type="KEGG" id="nev:NTE_00791"/>
    <dbReference type="eggNOG" id="arCOG01717">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009600_0_3_2"/>
    <dbReference type="OrthoDB" id="7931at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050566">
        <property type="term" value="F:asparaginyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895:SF176">
        <property type="entry name" value="AMIDASE AMID-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="29"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="477" mass="52395" checksum="0289D397F4FB5B08" modified="2014-10-29" version="1">MKKSSLYNPKLTIKDFAELVSSQSISCEELTEITLDRIRKLNPKLNGFITILEDSAKHDAKDADASIRRGKYKGPLHGVPISLKDLIYVKGVKSTSGSKILADFVPDYDSTVVRKLKEAGAIIVGMNNTHEFACGITNINPHYGPSRNPWDDSRMSGGSSGGSAVAVSAGMSLASIGTDTSGSIRVPSSLCGVFGLKPTYGRVSKYGVMPLAPSIDHIGPICRSPWDIAAVMQHIAGYDSHDPNSANAPVPNYIDEVEKTQGKFRLGIPKQFFFDIIDPKVKHTFDSFVERAESCQISSTHVDVDQTDKIYETWRAIRLGESATTHNEWLRTRHDDYGKDVAKMLDDGLKITAVHYISAHKWRQEIRGAILRAMKPYDALLVPTTPIAAPLLDQSTVHLDGKDIEVYPVLSRLTTVFDVTGLPALNIPAGLVDNRLPVGVQLVGRPFDEARLIQIAERYEQQYHVSEEMVPALNVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUB1</accession>
    <name>A0A075MUB1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Imidazole glycerol phosphate synthase subunit HisH</fullName>
            <ecNumber evidence="10">4.3.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">IGP synthase glutaminase subunit</fullName>
            <ecNumber evidence="10">3.5.1.2</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">IGP synthase subunit HisH</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">ImGP synthase subunit HisH</fullName>
            <shortName evidence="10">IGPS subunit HisH</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">hisH</name>
        <name evidence="13" type="ORF">NTE_03202</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="4.3.2.10"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 10">Heterodimer of HisH and HisF.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="4.3.2.10" evidence="10"/>
    <dbReference type="EC" id="3.5.1.2" evidence="10"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701667.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUB1"/>
    <dbReference type="STRING" id="1459636.NTE_03202"/>
    <dbReference type="GeneID" id="41598859"/>
    <dbReference type="KEGG" id="nev:NTE_03202"/>
    <dbReference type="eggNOG" id="arCOG00089">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071837_2_2_2"/>
    <dbReference type="OrthoDB" id="33401at2157"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000107">
        <property type="term" value="F:imidazoleglycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01748">
        <property type="entry name" value="GATase1_IGP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00278">
        <property type="entry name" value="HisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010139">
        <property type="entry name" value="Imidazole-glycPsynth_HisH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01855">
        <property type="entry name" value="IMP_synth_hisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42701">
        <property type="entry name" value="IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE SUBUNIT HISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42701:SF1">
        <property type="entry name" value="IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE SUBUNIT HISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000495">
        <property type="entry name" value="Amidotransf_hisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 10" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="12">
        <location>
            <begin position="6"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10 11">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <feature type="active site" evidence="10 11">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <feature type="active site" evidence="10 11">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000495-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIF85231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="217" mass="23801" checksum="35ED866DF191BDAE" modified="2014-10-29" version="1">MARIAIFDYGAGNLFSLKSALERNGAEKVDIIYDMSDLDRYDGLVLPGVGNFDPAIESIEKGAKRLDSAIEKGKPVMGICLGMEMLFNRSEEGRLEGLKILDGEVVMLPKGKVKVPHMGWNNLKITARGKNSSRFLKGIENDSWVYFVHSYKTVPADKKLVVASSDYGTTVPAVVEKGNLVGVQFHPEKSGDVGAKMIKNFLLMCEQAKAAEDKKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUH9</accession>
    <name>A0A075MUH9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methylase involved in ubiquinone/menaquinone biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_02299</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700936.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUH9"/>
    <dbReference type="STRING" id="1459636.NTE_02299"/>
    <dbReference type="GeneID" id="41598014"/>
    <dbReference type="KEGG" id="nev:NTE_02299"/>
    <dbReference type="eggNOG" id="arCOG01792">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG04124">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_965066_0_0_2"/>
    <dbReference type="OrthoDB" id="6467at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861:SF6">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Methyltransferase" evidence="2">
        <location>
            <begin position="159"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF84352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="326" mass="37718" checksum="69D8AF3D6547EB7F" modified="2014-10-29" version="1">MKVQFAHHLVCLQHNDKQIRLVLEPLATDSKNENECTEGFLRCPECGALYPVIQGVAITVRDFASYAAARSQTFGRWLLGAGTKEMKEFLKEKGSKLSPDTANDRYEEGGSWFVPYRWTQYEHTEEDRFIQHMRWRLRPNEVYNRVVHGINPDMDGVALDMACSMGYSTLLLAQKYAFAIGIDLSFSFIREARKKMQEKKLGNVEFCVADSLAPPFHPNKFDLVLAINLLELVDAEKLLASIHRMLKPHASTIIADPYDYNRDPPPKKSYDGQSFRRLVENSGFEIFEKSSKNESYIPWVLKVNERAYLYYFVDYLKAQKRSKEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUT6</accession>
    <name>A0A075MUT6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Heme/copper-type cytochrome/quinol oxidases, subunit 2</fullName>
            <ecNumber evidence="10">1.9.3.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NTE_00989</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome c oxidase subunit 2 family.</text>
    </comment>
    <dbReference type="EC" id="1.9.3.1" evidence="10"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699903.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUT6"/>
    <dbReference type="STRING" id="1459636.NTE_00989"/>
    <dbReference type="GeneID" id="41596817"/>
    <dbReference type="KEGG" id="nev:NTE_00989"/>
    <dbReference type="eggNOG" id="arCOG01236">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1623389_0_0_2"/>
    <dbReference type="OrthoDB" id="3372at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045187">
        <property type="entry name" value="CcO_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002429">
        <property type="entry name" value="CcO_II-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001505">
        <property type="entry name" value="Copper_CuA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22888:SF9">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22888">
        <property type="entry name" value="CYTOCHROME C OXIDASE, SUBUNIT II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00116">
        <property type="entry name" value="COX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00078">
        <property type="entry name" value="COX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50857">
        <property type="entry name" value="COX2_CUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0186">Copper</keyword>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome oxidase subunit II copper A binding" evidence="9">
        <location>
            <begin position="37"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIF83064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="163" mass="18238" checksum="19C5C24364327386" modified="2014-10-29" version="1">MGHATIEWVYIGVVVALLIYVGADAWNIERELDHAPPESKIIKVTAQQWFWTFEHEDGKKEIGELHLTKGVPYKFEITSRDVIHAFNVPDYTLMMDAVPGKINTLWVVPDQSGEFLIQCREYCGFSHYQMRAKLFVEEPAAGGNVTQVASDLTPSIGAQAVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUW8</accession>
    <name>A0A075MUW8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NTP pyrophosphohydrolase</fullName>
            <ecNumber evidence="4">3.6.1.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_02970</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="3.6.1.13" evidence="4"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701479.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUW8"/>
    <dbReference type="STRING" id="1459636.NTE_02970"/>
    <dbReference type="GeneID" id="41598641"/>
    <dbReference type="KEGG" id="nev:NTE_02970"/>
    <dbReference type="eggNOG" id="arCOG01073">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062658_5_2_2"/>
    <dbReference type="OrthoDB" id="104705at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047631">
        <property type="term" value="F:ADP-ribose diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006753">
        <property type="term" value="P:nucleoside phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019693">
        <property type="term" value="P:ribose phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03424">
        <property type="entry name" value="NUDIX_ADPRase_Nudt5_UGPPase_Nudt14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839:SF18">
        <property type="entry name" value="NUDIX HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839">
        <property type="entry name" value="UDP/ADP-SUGAR PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="48"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF85005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="199" mass="22508" checksum="B7751CF24E2824FF" modified="2014-10-29" version="1">MEKKEEEKKGWKRLGRKKVFEARNGKTVYMELFQDTVQTPKGRTLSYTHYRSSDVVIVVPFLDKKTLVMIKQYRYPLGKVLLEFPAGHVEKGESPLATAKRELREETGYSAKRVEHVYDYHPSVSKSRQVVHVFFAAGLAGGKTDHDSTEDIDVEIVKIASLRDMIRKRKVENAGTLIAYLLCCSSDGGGIKKINGKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVH1</accession>
    <name>A0A075MVH1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03134</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVH1"/>
    <dbReference type="STRING" id="1459636.NTE_03134"/>
    <dbReference type="KEGG" id="nev:NTE_03134"/>
    <dbReference type="HOGENOM" id="CLU_2476131_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="88" mass="9747" checksum="746F5BE64016CA65" modified="2014-10-29" version="1">MLDHLLAKPERIAARQAQFLICNECFWCASCLDPEFATGNCPSCNAAAVEDMPISANERYTFDYSVDRGVILEFTPKVRTASRAGQTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVH4</accession>
    <name>A0A075MVH4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Thermosome subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NTE_01192</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVH4"/>
    <dbReference type="STRING" id="1459636.NTE_01192"/>
    <dbReference type="KEGG" id="nev:NTE_01192"/>
    <dbReference type="eggNOG" id="arCOG01257">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008891_7_3_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03343">
        <property type="entry name" value="cpn60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012714">
        <property type="entry name" value="Thermosome_arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02339">
        <property type="entry name" value="thermosome_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="520"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="529"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF83264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="545" mass="58096" checksum="8FE0941AA5D5C3C1" modified="2014-10-29" version="1">MPVLILKEGASQTKGRDAQKNNITAAKLIAEVVRTSLGPRGMDKMLVDSLGDVTITNDGATILKEIDVQHPAAKMMVEISKATDNEVGDGTTSVVVLAGALIEKAEELINKDVHPTIIVDGYRKSAAKTIEVLNSIAQKIEGNEKSELARIARTSMQTKIVSREADDLAAIVVNAALSVAEKTDSGFRMDVDDIKVEKKAGGSIRDTKMIKGIVLDKEVVHGGMPKRIEGAKIALINAALEIEKTEFDAKINISSPDQMKMFLEEENKMLKGMVDKVIKAGANVVVCQKGIDDIAQHYLAKAGILTVRRVKESDMTKMSRATGARIVNNLDDLTAKDLGSAELVEERKVETDKWVFIEGCKHPKSVTILIRGGSQRVVDEADRSVHDALMVAKDVLEKPAIVAGGGAPEAYAAARLREWASTLSGREQLAAEKFAEALEVIPLALAENAGMDPIDTLTELRAKQSKGSKWTGVDARNAKVADMSKLDVVEPLAVKEQIIKSATEAASMILRIDDVIASSKSGGAPAMPPGGGGMGGGMGGMGMDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVY3</accession>
    <name>A0A075MVY3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phage integrase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_03387</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701828.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVY3"/>
    <dbReference type="STRING" id="1459636.NTE_03387"/>
    <dbReference type="GeneID" id="41599033"/>
    <dbReference type="KEGG" id="nev:NTE_03387"/>
    <dbReference type="eggNOG" id="arCOG01245">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_537058_0_0_2"/>
    <dbReference type="OrthoDB" id="386574at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF85415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="507" mass="58557" checksum="BAD63ADCF6CBAFB1" modified="2014-10-29" version="1">MAVVAGFQSTIKPSMPAPSLSSGDTSLKGIRKSRMRDDSGKRVADKGEIERRIVQLLEKPKTTGELAALMNRSSPKSFYRDYIKPMFERGLIEKDGDYWKRKGAAEETVRRERFEDLTDEAFGKLPCMQRLVKKMSEIERGDDFYGRIRRICTGQYIKGFKCHPEAWVAADNKDASTNAVTQTFVDAYKAEKGTTRLDSMTRQAVRYFYSYVIGREMTDAEKTEYGLDGKKDRIGMHNDVKLTDEQIDAGLDFFINKEENEEMAAYWAFAIETFGRPNRVFNADPDKFTFAKRKITKAIIEGFDEPIYEPKLVQFFRGLALVLPGKVRIETVESEIMTGELYESKTDRTWKKFALHPKSVAIIKAWVEQRRRAHRNTMFGDDGESYDEFALRINHELRKVYLHLGLIKPVCGCGKAFANNDDYLEHGRHKNRGKTGCPQWKKKAKTSYWEDRPSYTLRHCGAHLWLRRTGYNYGAVAAMGWEDLSTLRTWYGAFDMTQLEANLMREW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MW23</accession>
    <name>A0A075MW23_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">P pilus assembly protein, porin PapC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_03427</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1459636.NTE_03427"/>
    <dbReference type="KEGG" id="nev:NTE_03427"/>
    <dbReference type="HOGENOM" id="CLU_241989_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1120">
        <property type="entry name" value="Carboxypeptidase-like, regulatory domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="Carboxypeptidase regulatory domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117074">
        <property type="entry name" value="Hypothetical protein PA1324"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1233"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1260"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1631"/>
            <end position="1652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF85455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="1665" mass="178582" checksum="727A0CD6D0279350" modified="2014-10-29" version="1">MSVSAIILSTLLLFSIMYANPLLISKSISHLESLQSINAANIFQSLSLHAMQSSSNNNNSAEQQSSISLSIPLGVAYADSRSNNSTTSTSSTEDTADAGSGGIQSGNPTVLLSGTLYNDKNANGKRDLDDSGISGASIQVSYRPNGTSSQEHGETLKTGEDGSYRTFLPSTSTLIGIQTAVPEGYFETEGGDVHNPSWDNNNNNSSTLTSSFLYNDVQQISGKNIDFGFASIKDSAILVTGMVYEDLNGNGKRDSGEPGISDVGINISYLHPFTEYRIQTLSDGTYQAFLSPTAELVSESSSEPEGMTRTQPVNDVQIDNTTRTIASGIYEFGNLGSLTGPIQNIDFGYANPVANLTVRLQDENGNSIKGPSISFNDATTGQYIDTKKVDENGSVSISWIPAHKVNASIEMGSILYHAPNRNETIITLTRGRNNQIIHLDALKRESVAGTVTDVGGRPIDGMTITASEKVDSRNWFYSSTTDNAGHYNFTLLQGLVTIKGSNASYIVNDKSLDLNKADSPVKVDLTAELMPIHNVTTNVYSKYVGSGWVGPVNPSSENFFTAELTDEFGNHHYPRSDGLISFRGVLGDKIEECVRPYATFRLPESCRSMVLNDTQSIAASFYLQEGGRIEGRVIDAVTADPVSSWNAYLYSLNNDGRREWISSFWNNSQIIDVSVPKAGLYQLDIYSTYNDTDVSSHGSINPSNHFAQITTMVDNDKSALVGDVKLLRERSVVRNEGNAIASTPATAAPGNTITLHVSFNSIITQGMKNTPVLLLEVPANTTLVDKSIVLNGKQAAANYDGGAFYQIPLDGVVNGTSLAGTATYKIRLNDDFDKDGLNISAFLQYDSLESDGGIQKRQEVIGSLHIPVPQLSIDIPHQLTQRGTMVSGQGPAGGKIELYDGNTLLGQTDVSQGGFWRMNVTLPDSGDPAVHVLHANGIIINSSSKILHSRDATVIFDSTSPKLIEVCMQQDLNNRVCVNPELGVARFPYLSVWQYPYNFELRFDHPERVSDVKVFLDGTGGGMGNATLGSDGVYRATIVPSDNKSLGNVDVVYKLVPPDNISKVRIPTLPIQIPPPAGPSPGKLTIQDNNETDFSGRVSLEDGTVYKFASHATKNVKHTPTIAEIKEAISTQHPIFPISIVQTDVNGGLAIKGEVFVPDGAFSSEESGSTKTDFLDVSVDEELHGTLVDFALAPEDSGMQAKSVGNLQSVNYLGTAILQGQIVAHPNGITRGALAGVIGTIVGAQLGMAGLLAAYSTISFLGALGTAFGIGAVLAAGICWAICDEVDPTYLFDPSGFVYEAVPSNRLQNVTATILEQDPKTKQWHVWDAQEFGQINPETVDSDGHYAWDVPEGDWKITYQKPGYQQASSEIIHEPPPRYDVNIGMVSLAAPSVIAVSALAHVDGGTSKNTNSSSIRVQFDKYILANNVENTTITVAGLNGITIPVSTVNAPDGKLLTREIDFVPSQPLVEGSTYSLHVTHRSIVSYASVPMDGDYDDKVVAIGKTSYDLQLTSNGHSLITNSLTNIENADTTSAAVSVTLGQPLIAIAKTNDNLASKTIIIHWSGPDGKIRKTESASPTMNDDTLVSQPFYPTETGQWTATATFADGTPDNSIASKTRNFTVNYDAPVPEFGLNNIAGIIAAISIAISIIITKTGNFSLFGRRWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MW65</accession>
    <name>A0A075MW65_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Protein translation factor SUI1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NTE_01470</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the SUI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_075053575.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MW65"/>
    <dbReference type="STRING" id="1459636.NTE_01470"/>
    <dbReference type="GeneID" id="41597263"/>
    <dbReference type="KEGG" id="nev:NTE_01470"/>
    <dbReference type="eggNOG" id="arCOG04223">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082805_6_1_2"/>
    <dbReference type="OrthoDB" id="11182at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002188">
        <property type="term" value="P:translation reinitiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11567">
        <property type="entry name" value="YciH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00604">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050318">
        <property type="entry name" value="DENR/SUI1_TIF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022851">
        <property type="entry name" value="SUI1_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005872">
        <property type="entry name" value="SUI1_arc_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002096">
        <property type="entry name" value="PRK00939.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12789:SF0">
        <property type="entry name" value="DENSITY-REGULATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12789">
        <property type="entry name" value="DENSITY-REGULATED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037511">
        <property type="entry name" value="Transl_init_SUI1_pro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 5" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="SUI1" evidence="6">
        <location>
            <begin position="27"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR037511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF83534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="102" mass="11321" checksum="6BE90221E6641FEE" modified="2014-10-29" version="1">MAVICKKCGLPDDLCACGELDKEDARIVIRLETRRWSKTTTLIEGINPKLSDMQKIVKDLKSSFACGGTAKDGFIMLQGDHRDDVKGYLVKKGFSEEAIEVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWG5</accession>
    <name>A0A075MWG5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zn-dependent hydrolase, glyoxylase</fullName>
            <ecNumber evidence="3">3.1.2.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_01556</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.2.6" evidence="3"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWG5"/>
    <dbReference type="STRING" id="1459636.NTE_01556"/>
    <dbReference type="KEGG" id="nev:NTE_01556"/>
    <dbReference type="eggNOG" id="arCOG00517">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030571_5_3_2"/>
    <dbReference type="OrthoDB" id="197151at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004416">
        <property type="term" value="F:hydroxyacylglutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050313">
        <property type="term" value="F:sulfur dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070813">
        <property type="term" value="P:hydrogen sulfide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07724">
        <property type="entry name" value="POD-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051682">
        <property type="entry name" value="Mito_Persulfide_Diox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044528">
        <property type="entry name" value="POD-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43084">
        <property type="entry name" value="PERSULFIDE DIOXYGENASE ETHE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43084:SF1">
        <property type="entry name" value="PERSULFIDE DIOXYGENASE ETHE1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="2">
        <location>
            <begin position="12"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF83619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="208" mass="22903" checksum="4233C7B40ECF0A85" modified="2014-10-29" version="1">MKVLQIPVGQMANFTYIIADDEETDEAAVIDPSWNLEKVFDALKKNGWTAKYVINTHSHFDHVLGNEQVAKVTGAKIVQHKASALERDIEVQDGDTIKVGNSISLRVVHTPGHSKDSICLVLDGKLVFTGDTLFVGNCGRTDLPGSDPAEMYDSLFGKVAKLDESLLMYPGHDYGSKPTSTIGHEKKFNYVLSPRTKQEFLEFMGSGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MX32</accession>
    <name>A0A075MX32_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exo-alpha-sialidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701639.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MX32"/>
    <dbReference type="STRING" id="1459636.NTE_03170"/>
    <dbReference type="GeneID" id="41598828"/>
    <dbReference type="KEGG" id="nev:NTE_03170"/>
    <dbReference type="HOGENOM" id="CLU_033612_0_0_2"/>
    <dbReference type="OrthoDB" id="2272at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd15482">
        <property type="entry name" value="Sialidase_non-viral"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="Sialidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="596" mass="66103" checksum="6B329B11EEFAEF62" modified="2014-10-29" version="1">MTSNPITTEMLYQEMAVSFFKAQTLVSDASLLIARLAAFRNKVYLVWQEGAKIDPNNSASTRSDEEKLDAEINAHSAIKYRISSDYGNVFGEMATLYQCNIAQYVPPAMEMSPAGRVFLAWGDGNKEATDSVVFFCRSNDDGSGFEDPVIINNKDDSESKTTDSSAATTISSRKVSAESKTEGVTEFDEKRKEFFRRGYLVPRVKLAAAGDNVYIFWSETKGQLYTDVEYRLFFRASNDGGRTFGSKKIIGTTTVKASEFLRMFQINLTASGDEVYMMWVQFTPVPGYMFSGRPNPLKAYVAISRNAGKTLERTIDLSEDTIVVQGDRQENKDDASGDRVGRTRRSVFEKLPFEIVAAGEGVLYMVLIGHESYGQRDFLESLMRFRPSTEGGKTTPVASNAANPNLLDINLPIYFAKSVDYGSSFTNPVYLEDYSAGIDDTYLLRSDKDVHVIWRAVAQGGVLMSRTSTDGGKSFQPTVQIPKIKIFHPTGSPSNSGAIITSPNGRIFIAMRKDIQSRLSKPLEPDSEMFFSASFDAGMTFTDTTRLSENPGGDSVHNTCVYPSIYSVNGKYVYIAWSEIQNGSSFSLKFRKGIIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MX34</accession>
    <name>A0A075MX34_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14 15 16">Dihydroxy-acid dehydratase</fullName>
            <shortName evidence="15">DAD</shortName>
            <ecNumber evidence="14 15 16">4.2.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">ilvD</name>
        <name evidence="19" type="ORF">NTE_01783</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:24809"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:24810"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate = (S)-3-methyl-2-oxopentanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:27694"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
        <text evidence="15">Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.</text>
    </comment>
    <comment type="pathway">
        <text evidence="13 15">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12 15">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the IlvD/Edd family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.9" evidence="14 15 16"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700542.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MX34"/>
    <dbReference type="STRING" id="1459636.NTE_01783"/>
    <dbReference type="GeneID" id="41597549"/>
    <dbReference type="KEGG" id="nev:NTE_01783"/>
    <dbReference type="eggNOG" id="arCOG04045">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014271_4_2_2"/>
    <dbReference type="OrthoDB" id="8674at2157"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00057"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00061"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004160">
        <property type="term" value="F:dihydroxy-acid dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.80:FF:000001">
        <property type="entry name" value="Dihydroxy-acid dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="entry name" value="IlvD/EDD C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00012">
        <property type="entry name" value="IlvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050165">
        <property type="entry name" value="DHAD_IlvD/Edd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004404">
        <property type="entry name" value="DihydroxyA_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056740">
        <property type="entry name" value="ILV_EDD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="ILV_EDD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00110">
        <property type="entry name" value="ilvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002068">
        <property type="entry name" value="PRK00911.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21000">
        <property type="entry name" value="DIHYDROXY-ACID DEHYDRATASE DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21000:SF5">
        <property type="entry name" value="DIHYDROXY-ACID DEHYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24877">
        <property type="entry name" value="ILV_EDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="IlvD/EDD N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00887">
        <property type="entry name" value="ILVD_EDD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 15" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3 15" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 15" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="7 15" id="KW-0408">Iron</keyword>
    <keyword evidence="8 15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 15 19" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase N-terminal" evidence="17">
        <location>
            <begin position="33"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase C-terminal" evidence="18">
        <location>
            <begin position="364"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="472"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="15">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="446"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="15">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="NCBIfam" id="TIGR00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF24877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="AIF83844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="559" mass="59209" checksum="DB47A9E45428FA19" modified="2014-10-29" version="1">MELPSRKVVEGAARAPHRAMYKAMGLTDEDLNRPIVGVSSTCNEATPCNIHLGQLAQSAKRGVSEAGCTPREFTAIAVSDAIAMGHEGMKASLVSREIIADSIEVMVRAHGYDGVVGISGCDKSLPGTLMGMARLNLPSVFVYGGTIMPGEWNGKQVTVQDVYEGVGAYDAGKMTLQELISLENVACPTAGSCAGMYTANTMASISEALGMSLPGSASPPAESDRRHEICYNTGKAVMNLIDSNIRPRDILTYEAFENAIMMANAIGGSTNAVLHLLAIARETGVKLVLSDFEKIRKKTPHIADMRPGGMYVMLDLDKIGGVPVIMNALLKKGLLNGNVMTVTGKTMKENLASMTFDLSQGKEKVVRRLEEPISSEGTLKILKGTLAPDGAVVKVAGVKSKKFVGRARVFDSEEKAFDAVSQRKIVEGDVVVIRYEGPKGGPGMREMLATTAAIVGQGLGEKVAMVTDGRFSGATRGFMIGHVAPEAMVGGPIALVKEGDQIAIDTATSKIDLVVSKAELARRAKKWKPIKPHYRSGALAKYASLVQSASEGAITVPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MX48</accession>
    <name>A0A075MX48_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01803</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MX48"/>
    <dbReference type="STRING" id="1459636.NTE_01803"/>
    <dbReference type="KEGG" id="nev:NTE_01803"/>
    <dbReference type="eggNOG" id="arCOG07088">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_920150_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="304" mass="34172" checksum="123B40E284B96C32" modified="2014-10-29" version="1">MSSRKIHYLSLFSFSVILFAGIFLNSSFETSVRAAFAVNPTFNATKGYQYIANQYNATYGLVRESETIPTYWLWTDNLLASEVLKDYNYQMSANITSSIKVYTSNYDLDYRHPQGVLFNNVAYFNGVTNKQVNGAVWYSDSDGQELSCGDYADIAFLKSMYLYKAGKFIDAKTCYDMGASMFDGIGMRDSAFNGDGQRYSTYKLALWQIASNVTGYPIPKEPMMIIPFMQNQTTGGIYTHYRADLTPDSLTNVETTSLVIMAEKGVTHEKPAAIASENQHLEMIKWLIGAFVVAGFAILLFKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MY94</accession>
    <name>A0A075MY94_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MY94"/>
    <dbReference type="STRING" id="1459636.NTE_02165"/>
    <dbReference type="KEGG" id="nev:NTE_02165"/>
    <dbReference type="eggNOG" id="arCOG04936">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_907937_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00761">
        <property type="entry name" value="Glyco_tranf_GTA_type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050834">
        <property type="entry name" value="Glycosyltransf_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43685">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43685:SF2">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 2-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="1">
        <location>
            <begin position="13"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="286" mass="33151" checksum="6F3D03FC1A5E3C56" modified="2014-10-29" version="1">MSNLTCVLSSYFVIVTCRNSENNIEEALLSLRAQTVPPSYVIVIDDGSRDRTADILRQLQSGWPSLHIITNPDLGYNIARVVSNWNKAIQYTRDHRLPRTDYHMISTDDTVYERDYAEKMMRHMDADGKIAIASGNYEDKPAIAPHGGGRFVRTEFFDKHHGLYPEKMGYESLVLYSATRHGYTFQVFDDARFEHTRPLGKNHHFYEFGASMRTLGYHPLFALGRFFLYFASGKPTGRLGAIYMLYYYLSYKPKETGYDSMHDSEIRRYIRNYQFTRIKKKLGVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MY96</accession>
    <name>A0A075MY96_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SWIM zinc finger-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_02170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700837.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MY96"/>
    <dbReference type="STRING" id="1459636.NTE_02170"/>
    <dbReference type="GeneID" id="41597894"/>
    <dbReference type="KEGG" id="nev:NTE_02170"/>
    <dbReference type="eggNOG" id="arCOG01120">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2271131_0_0_2"/>
    <dbReference type="OrthoDB" id="12242at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="35"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF84224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="102" mass="11619" checksum="464A69108F11470F" modified="2014-10-29" version="1">MSRIDSAVESGSVKMLRFAPSGRTLWIVVGRDSEYWTDPELGFCSCKDFYFSSLTKGEPCYHLKSVHKAMLDEKFVAFEFSDDEYTAFLQALVQDSASQLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MYC0</accession>
    <name>A0A075MYC0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">D-isomer specific 2-hydroxyacid dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MYC0"/>
    <dbReference type="STRING" id="1459636.NTE_02200"/>
    <dbReference type="KEGG" id="nev:NTE_02200"/>
    <dbReference type="HOGENOM" id="CLU_019796_0_1_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008863">
        <property type="term" value="F:formate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42938">
        <property type="entry name" value="FORMATE DEHYDROGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42938:SF9">
        <property type="entry name" value="FORMATE DEHYDROGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="1">
        <location>
            <begin position="32"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="177" mass="19873" checksum="0D484173DC60BC0B" modified="2014-10-29" version="1">MKIVAVLYPGGEIARKTPELLGCAENALGLTDFLKSQGHEFVVLTDKEAELDKQLPTTDILITTPFWPAYDTKERISKAPKLKLALTAGVGSDHIDLEAAAARNIIMAEITGSNVVSVAEQVVMHILALVRNYIPAYNRFPKENGILQKLRQKHMIWKIKLWEYLEWEGLDNVYAKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MYC4</accession>
    <name>A0A075MYC4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein (ATP-grasp superfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700866.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MYC4"/>
    <dbReference type="STRING" id="1459636.NTE_02205"/>
    <dbReference type="GeneID" id="41597926"/>
    <dbReference type="KEGG" id="nev:NTE_02205"/>
    <dbReference type="eggNOG" id="arCOG00348">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1222478_0_0_2"/>
    <dbReference type="OrthoDB" id="31247at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10900">
        <property type="entry name" value="PAC-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019151">
        <property type="entry name" value="Proteasome_assmbl_chaperone_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038389">
        <property type="entry name" value="PSMG2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35610:SF7">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35610">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09754">
        <property type="entry name" value="PAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159659">
        <property type="entry name" value="Cgl1923-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="230" mass="25398" checksum="80AF89D49F1C060C" modified="2014-10-29" version="1">MKAVMVEDADIRKPIVIAAMQDMGNVGSIAIDFINKSLGTRPFRQISIPFPNYVVDSGGYIDFQRERWEYRYGSDGSVVVFGGGMGQPQTNQELYDLCEDVVGIARQYSAQLVYTLGAFHTDRKYGKNPKTFFAATTQELAGQIQRLGLEPTPGSSLITGFNGLILGLAKESGLQGIGLYAEIDDPQIPQFRAAKSLLVTLEKLTYQKFRGMEELDEMASRVESEGGKEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MYL9</accession>
    <name>A0A075MYL9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Branched-chain-amino-acid aminotransferase</fullName>
            <shortName evidence="16">BCAT</shortName>
            <ecNumber evidence="16">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">ilvE</name>
        <name evidence="17" type="ORF">NTE_02306</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 16">Acts on leucine, isoleucine and valine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 16">
            <text>L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 16">
            <text>L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 16">
            <text>L-valine + 2-oxoglutarate = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 16">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 16">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 16">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 15">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="16"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700943.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MYL9"/>
    <dbReference type="STRING" id="1459636.NTE_02306"/>
    <dbReference type="GeneID" id="41598021"/>
    <dbReference type="KEGG" id="nev:NTE_02306"/>
    <dbReference type="eggNOG" id="arCOG02297">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020844_3_1_2"/>
    <dbReference type="OrthoDB" id="6469at2157"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00058"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00073"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00062"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052656">
        <property type="term" value="F:L-isoleucine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052654">
        <property type="term" value="F:L-leucine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052655">
        <property type="term" value="F:L-valine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.10.10:FF:000002">
        <property type="entry name" value="D-alanine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005785">
        <property type="entry name" value="B_amino_transI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050571">
        <property type="entry name" value="Class-IV_PLP-Dep_Aminotrnsfr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01122">
        <property type="entry name" value="ilvE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005146">
        <property type="entry name" value="PRK06606.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42743">
        <property type="entry name" value="AMINO-ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42743:SF11">
        <property type="entry name" value="AMINODEOXYCHORISMATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 16 17" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="11 16" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="10 16" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 16 17" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU364094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AIF84359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="305" mass="34035" checksum="8FA8178EEDD898DB" modified="2014-10-29" version="1">MKEKGGEFIWFDGKFVKWEDAKVPVFTHALHYGTAVFEGIRGYSSNDNVFVFRLQEHMERLHRSANVYSLTLKHSAEELSDATVELLKKNRMRESVYIRPLTFVGLHGIDLNVTKDSPTHTIIVAFPFAKYFKGDGLKVRVSSWRRISDQTTPPLAKAAGNYLNSVLATQECRRDGYDESILLDIAGNVSEASGENIFVVRKDKIYTPYFADSALEGITRESAITIARGMGYSVIERPIPRAELYMADEIFLTGTAAEIVPVTSVDGHAIGTGKEGPVSKSIRQTYEKVVTGGVKEYAGWLTPVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MZB1</accession>
    <name>A0A075MZB1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02542</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701133.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MZB1"/>
    <dbReference type="STRING" id="1459636.NTE_02542"/>
    <dbReference type="GeneID" id="41598239"/>
    <dbReference type="KEGG" id="nev:NTE_02542"/>
    <dbReference type="HOGENOM" id="CLU_1987514_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="125" mass="14286" checksum="E7D914CEBE56DE15" modified="2014-10-29" version="1">MDTIKDNVNCTVYLNHHFAKTIDTYLDSFKSLRFDVKQTRASAIKHMAASYSSIFNLDNMALLKKYDELQRTTAIGKSSKDLYSELKQEANNAVKEKLTNAINNLSQRAGKFATFEALDSLRNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MZB6</accession>
    <name>A0A075MZB6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02547</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MZB6"/>
    <dbReference type="KEGG" id="nev:NTE_02547"/>
    <dbReference type="HOGENOM" id="CLU_200166_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="57" mass="6641" checksum="1587D8B3EF6EBC3B" modified="2014-10-29" version="1">MLMPYEIRSIDDEEEEKNAFPKYCSECSRPATSEAMFDLWGSTAIQFFCKHCLPKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N0B5</accession>
    <name>A0A075N0B5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02896</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987015.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N0B5"/>
    <dbReference type="GeneID" id="41598575"/>
    <dbReference type="KEGG" id="nev:NTE_02896"/>
    <dbReference type="eggNOG" id="arCOG01580">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1500240_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043200">
        <property type="term" value="P:response to amino acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30154">
        <property type="entry name" value="LEUCINE-RESPONSIVE REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30154:SF34">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR AZLB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="180" mass="20938" checksum="B2F38428EB2C6320" modified="2014-10-29" version="1">MMPDDTDELILSALSRNAKQDPLEIWDFLKGHGHDVPIEEIESRITKLEDEGVITGYTISVDTRKLRRRVIRVVLATFKTSQHLPKRLEGLKKYVADAPFVLFSGRTRGGYDWICVQAFPSEEMADEESDIYRNLFGDIIQSYQVYDFMPVKDPSFHSLAYTSKEYKKFLDEWIPPFLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N1A0</accession>
    <name>A0A075N1A0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">prephenate dehydratase</fullName>
            <ecNumber evidence="2">4.2.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NTE_03210</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>prephenate + H(+) = 3-phenylpyruvate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:21648"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:18005"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="EC" id="4.2.1.51"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-phenylalanine biosynthesis; phenylpyruvate from prephenate: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.51" evidence="2"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701674.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N1A0"/>
    <dbReference type="STRING" id="1459636.NTE_03210"/>
    <dbReference type="GeneID" id="41598867"/>
    <dbReference type="KEGG" id="nev:NTE_03210"/>
    <dbReference type="eggNOG" id="arCOG00255">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035008_1_0_2"/>
    <dbReference type="OrthoDB" id="8755at2157"/>
    <dbReference type="UniPathway" id="UPA00121">
        <property type="reaction ID" value="UER00345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004664">
        <property type="term" value="F:prephenate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009094">
        <property type="term" value="P:L-phenylalanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04905">
        <property type="entry name" value="ACT_CM-PDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13631">
        <property type="entry name" value="PBP2_Ct-PDT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000034">
        <property type="entry name" value="Chorismate mutase/prephenate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.260:FF:000012">
        <property type="entry name" value="Prephenate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008242">
        <property type="entry name" value="Chor_mutase/pphenate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001086">
        <property type="entry name" value="Preph_deHydtase"/>
    </dbReference>
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        <property type="entry name" value="Preph_deHydtase_CS"/>
    </dbReference>
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        <property type="entry name" value="PRK11898.1"/>
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    </dbReference>
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        <property type="entry name" value="PREPHENATE DEHYDRATASE P PROTEIN"/>
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    </dbReference>
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        <property type="entry name" value="PREPHENATE DEHYDRATASE-RELATED"/>
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        <property type="entry name" value="ACT"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00800">
        <property type="entry name" value="PDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001500">
        <property type="entry name" value="Chor_mut_pdt_Ppr"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ACT-like"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0584">Phenylalanine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prephenate dehydratase" evidence="8">
        <location>
            <begin position="3"/>
            <end position="179"/>
        </location>
    </feature>
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        <location>
            <begin position="201"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023222"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIF85239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="282" mass="31635" checksum="E1F42FF4E089CAF0" modified="2014-10-29" version="1">MPSVAFQGERGAFSEMAALQYFSKGATLVPCKSFADAFSEAEKKKVDYAVIPVENSIEGSVPEVYDLLMQTPLKATGEVYHRVHHCLIAGKGVKIKDVRHAYSHPQALGQCRQYLQKKRIEPVPAYDTAGSVKMVKEQGAKDAAAIASRRAAELYGMEILDEGIEDRKSNYTRFLVLALSDNDDKRARKNNEQQQQQYKTSIIFSVKHVPGALFGILGEFAIRNLNLTKIESRPTKETPWEYNFYVDFEGHANDTAVKQVLKAVKSKTSYLKIIGSYRKAEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N1J6</accession>
    <name>A0A075N1J6_9ARCH</name>
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        <submittedName>
            <fullName evidence="9">NADH:ubiquinone oxidoreductase chain I-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NTE_03310</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
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    <dbReference type="GeneID" id="41598961"/>
    <dbReference type="KEGG" id="nev:NTE_03310"/>
    <dbReference type="eggNOG" id="arCOG00291">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2340274_0_0_2"/>
    <dbReference type="OrthoDB" id="5583at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050572">
        <property type="entry name" value="Fe-S_Ferredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43687">
        <property type="entry name" value="ADENYLYLSULFATE REDUCTASE, BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43687:SF6">
        <property type="entry name" value="L-ASPARTATE SEMIALDEHYDE SULFURTRANSFERASE IRON-SULFUR SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="5"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="44"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF85339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="97" mass="10720" checksum="F200C50D886668D3" modified="2014-10-29" version="1">MPIAILPDVDEQRCIGCALCVEICTALGPDVLRVKPVEGWKRGKAFVFYPERCISDGACVGVCPTHAIFWMRPMEYTPGQPVPLHKNGVFSKGWEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N285</accession>
    <name>A0A075N285_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03526</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385706.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N285"/>
    <dbReference type="GeneID" id="43502690"/>
    <dbReference type="KEGG" id="nev:NTE_03526"/>
    <dbReference type="HOGENOM" id="CLU_3162932_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="47" mass="5519" checksum="AABC465BC9D6AEBC" modified="2014-10-29" version="1">MKVYVVLRETAKEEGGDKIVAIYGNERKALDEIEEDESCYYLEYEVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MKY3</accession>
    <name>A0A075MKY3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00017</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699172.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MKY3"/>
    <dbReference type="STRING" id="1459636.NTE_00017"/>
    <dbReference type="GeneID" id="41595971"/>
    <dbReference type="KEGG" id="nev:NTE_00017"/>
    <dbReference type="HOGENOM" id="CLU_2392997_0_0_2"/>
    <dbReference type="OrthoDB" id="376389at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="98" mass="10253" checksum="5CA659C0F1814546" modified="2014-10-29" version="1">MMTMMIKYVLAGVAAGAASATYLAFYYQPILLNGAIHAAIFASGLVAMYLAKSLTAKKAGAYVAGALPVHLAIHFVVIRDLPQLIGASHLLLNLPSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLF1</accession>
    <name>A0A075MLF1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aspartate kinase</fullName>
            <ecNumber evidence="3">2.7.2.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_00019</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aspartokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.4" evidence="3"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699174.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLF1"/>
    <dbReference type="STRING" id="1459636.NTE_00019"/>
    <dbReference type="GeneID" id="41595973"/>
    <dbReference type="KEGG" id="nev:NTE_00019"/>
    <dbReference type="eggNOG" id="arCOG00861">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_579551_0_0_2"/>
    <dbReference type="OrthoDB" id="8904at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009090">
        <property type="term" value="P:homoserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1320">
        <property type="entry name" value="Aspartokinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2130.10">
        <property type="entry name" value="VC0802-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042199">
        <property type="entry name" value="AsparK_Bifunc_asparK/hSer_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21499">
        <property type="entry name" value="ASPARTATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21499:SF59">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aspartate/glutamate/uridylate kinase" evidence="2">
        <location>
            <begin position="5"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF82103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="484" mass="53662" checksum="FECE67873396F1FF" modified="2014-10-29" version="1">MTTAVTVAKFGGSALGADGVLIPKIMDRLKQIMSESKVVAVFSAPMIEYDGKVSSMTDVAIKVGRNYASSNPVEIEVLREVYERIATRYLDEERKKAFLDQLDKFYRQVIISLKVAAENRRFVDVIRSRTLAYSGEVTMSYLMGYVMQAHGIKAAHVPIEHWPIITDDNFEAANFMASESRQNAGHLIELVESNDVVSMGGFIGKTADGLETTYERGGSDRTAADIAIILSGDKYETKISFEKDSAVLSADPKIVKDGLDFVPYLSYNEARIAGMFGMKILDPIAIKEIDDNGLDIPLVVTNMTRPDSVTVIKRTPPSDDQSNPIKIVTGKKNCAIVRMETIAASHLIASLESDRQYHEFVKLSPYVKDDVEMTRLLFLDADYVRRHERHFRAYYQKAEIVYGRAVVTLIGDEMWRVPKIASTASSNVSEHDINILNLDAQEETSRILIVVEDKANSVADAVKAIHHTRVKMHGRRGGGGSSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLG0</accession>
    <name>A0A075MLG0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ketosteroid isomerase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00024</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699177.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLG0"/>
    <dbReference type="STRING" id="1459636.NTE_00024"/>
    <dbReference type="GeneID" id="41595976"/>
    <dbReference type="KEGG" id="nev:NTE_00024"/>
    <dbReference type="eggNOG" id="arCOG06513">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1025269_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030638">
        <property type="term" value="P:polyketide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009959">
        <property type="entry name" value="Cyclase_SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38436:SF1">
        <property type="entry name" value="ESTER CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38436">
        <property type="entry name" value="POLYKETIDE CYCLASE SNOAL-LIKE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07366">
        <property type="entry name" value="SnoaL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="20"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="271" mass="30030" checksum="3C7F5DF91D26FC3C" modified="2014-10-29" version="1">MMESNKSSSNNNNAQQVVISYLKALENRDFKAARSYMHDNMSFSGPMASHHRPDALLKDLEPLCPLKYEIKKAFAVEGNENDVCLLYDLTIGTPAVTLFTCGWYRVQDGKISSIRTVFDPRPFAAAASGSKKKLVERHYANVSEGRIERDREVMSDDIVHVSAAAGTVSGIKDFLAFVSGFKRAFPDLRFDIRASIEGADTVITEGVFIGTNTGPMAGPNGSMMPATGRKVELPFCDVWKVRNERIVENHIYYDQLAFLGQLGLIPQQAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLQ1</accession>
    <name>A0A075MLQ1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699403.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLQ1"/>
    <dbReference type="GeneID" id="41596235"/>
    <dbReference type="KEGG" id="nev:NTE_00339"/>
    <dbReference type="HOGENOM" id="CLU_173770_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="103" mass="12014" checksum="39E28CA7F1056760" modified="2014-10-29" version="1">MSKDHAIDRIDWKVLKGKEARGVNENVDFGEIHEMGNTYIVTKKGLATKDTYYLPKALAQKYDGRTVWFNITQDQKGRFRREYPPSDEEYSKYNTSMDSLADK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MM10</accession>
    <name>A0A075MM10_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Deoxycytidylate deaminase</fullName>
            <ecNumber evidence="4">3.5.4.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_00439</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="3.5.4.12" evidence="4"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701982.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MM10"/>
    <dbReference type="STRING" id="1459636.NTE_00439"/>
    <dbReference type="GeneID" id="41596315"/>
    <dbReference type="KEGG" id="nev:NTE_00439"/>
    <dbReference type="eggNOG" id="arCOG01487">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047993_2_3_2"/>
    <dbReference type="OrthoDB" id="7284at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004132">
        <property type="term" value="F:dCMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006220">
        <property type="term" value="P:pyrimidine nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01286">
        <property type="entry name" value="deoxycytidylate_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016473">
        <property type="entry name" value="dCMP_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015517">
        <property type="entry name" value="dCMP_deaminase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035105">
        <property type="entry name" value="Deoxycytidylate_deaminase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086:SF18">
        <property type="entry name" value="DEOXYCYTIDYLATE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086">
        <property type="entry name" value="DEOXYCYTIDYLATE DEAMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006019">
        <property type="entry name" value="dCMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="3">
        <location>
            <begin position="5"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF82521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="179" mass="19495" checksum="8F8184039B50674A" modified="2014-10-29" version="1">MQRPDWDTYFMLQAEIAKLRSNCLTRHIGAVIVKENRQIATGYNGTPPGIKNCFEGGCPRCLARVRGEVKSGESLDRCLCTHAEANAIMQCAMFGNAGSTRGATLYSTFAPCIECSKMAISVGIKRIVVIADYPEDGTQLLRDAGVELVKLNPEKLSPWLTIIPQDPESSAKAVSSSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MME9</accession>
    <name>A0A075MME9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00346</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="KEGG" id="nev:NTE_00346"/>
    <dbReference type="HOGENOM" id="CLU_3227626_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="43" mass="5075" checksum="033AE26DFDFD04E4" modified="2014-10-29" version="1">MFENIIKLASFIKPALLMINVWTGISLWERGYISILHYFTTNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMP0</accession>
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        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">NTE_00023</name>
    </gene>
    <organism evidence="1 2">
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        <lineage>
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            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000028194">
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="31" mass="3448" checksum="AE2760CD312B32F6" modified="2014-10-29" version="1">MGSQKVGATNLFNSLQQEYDQDNSFVENLIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMV4</accession>
    <name>A0A075MMV4_9ARCH</name>
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        <submittedName>
            <fullName evidence="6">DNA repair exonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NTE_00691</name>
    </gene>
    <organism evidence="6 7">
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        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
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            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
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    <dbReference type="STRING" id="1459636.NTE_00691"/>
    <dbReference type="GeneID" id="41596547"/>
    <dbReference type="KEGG" id="nev:NTE_00691"/>
    <dbReference type="eggNOG" id="arCOG00397">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026621_5_2_2"/>
    <dbReference type="OrthoDB" id="11638at2157"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00840">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050535">
        <property type="entry name" value="DNA_Repair-Maintenance_Comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041796">
        <property type="entry name" value="Mre11_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30337">
        <property type="entry name" value="COMPONENT OF ATP-DEPENDENT DSDNA EXONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30337:SF0">
        <property type="entry name" value="NUCLEASE SBCCD SUBUNIT D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0269">Exonuclease</keyword>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="381"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="383"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="407"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF82771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="418" mass="45996" checksum="4F58EE108680BBC8" modified="2014-10-29" version="1">MLVAHVSDLHLGYSQFGLEEREEDVYATFNEAVDISIREGVELVILGGDIFHTPRPNGKAIITLANALKKLKEKQIPVAYVLGEHDISRMRDVPLAHVFSNLGLAKKLRLDEPFVVGDCAVYGADKERRSNIDALLERLHNIEKMTGNREKRKRILVLHQGLTDMNKFAGEINSTDLPAGFDYYAMGHYHDHIEKRYQNLGGALLVYPGSIELTPSEGIKEVDKGFVLVDMSGQEATTNWVTLSSRRPQFSMNIDYDRLTEGIDDIISKASSFAKKPVVKVLVDGKNLDPKVIAANLRRLNESCLHYVWQPADEQLSSSSLAFDERPADLDAELLRLAKDALGSEEAANLAVRDLLPPAAGGNAGAVLDIVWDIFKKKRLSGDNDNSDAALAAADDNNNNSTPQNNEGKEEGGVVKGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMX5</accession>
    <name>A0A075MMX5_9ARCH</name>
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        <submittedName>
            <fullName evidence="3">Cupredoxin-like domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_00721</name>
    </gene>
    <organism evidence="3 4">
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        <lineage>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMX5"/>
    <dbReference type="STRING" id="1459636.NTE_00721"/>
    <dbReference type="GeneID" id="41596573"/>
    <dbReference type="KEGG" id="nev:NTE_00721"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028096">
        <property type="entry name" value="EfeO_Cupredoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13473">
        <property type="entry name" value="Cupredoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EfeO-type cupredoxin-like" evidence="2">
        <location>
            <begin position="77"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF82801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="184" mass="18811" checksum="098A508D7B2D5712" modified="2014-10-29" version="1">MDARKTKIIVPIVIAIAIAGTAVAVLSSTGGAQRNNVSTLATSGLTSNNYNTDSSAAASTSTTTTATDAKPTAASTATSSSIKMSAKEEDETYRWVTSDGGSNPSLKMSANTDNVVQIDNPTDAKHELVINDSSGKEVGSSGDIAPNGSGQLSFKPTAAGTFEYHCEYHPDTMKGTIEVSGSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMY2</accession>
    <name>A0A075MMY2_9ARCH</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00433</name>
    </gene>
    <organism evidence="2 3">
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        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699472.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMY2"/>
    <dbReference type="GeneID" id="41596311"/>
    <dbReference type="KEGG" id="nev:NTE_00433"/>
    <dbReference type="eggNOG" id="arCOG08765">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1444622_0_0_2"/>
    <dbReference type="OrthoDB" id="6584at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="187" mass="21138" checksum="E06B9E2EFA54D2D5" modified="2014-10-29" version="1">MRSALEKDDDRRTRKVFLAVFYVCATAMALITFYAMYVSLDEYQRTGSVIIGKVLVDTEWPVPGVAKLVTYLMIVSVVAWYCVVRLGGDKVSGMPKWIKSILQLVVLMIAVVALYEFVYNFIVWNSLITADAIKGVLDFDNKSVEYPNPETPWNLVFATKMSLAAFLIAAHGFYTMSKPNKRDQVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMY8</accession>
    <name>A0A075MMY8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Vitamin B12-dependent ribonucleotide reductase</fullName>
            <ecNumber evidence="13">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">NTE_00110</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 13">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + [thioredoxin]-disulfide + H2O = a ribonucleoside 5'-diphosphate + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the ribonucleoside diphosphate reductase class-2 family.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="13"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMY8"/>
    <dbReference type="STRING" id="1459636.NTE_00110"/>
    <dbReference type="KEGG" id="nev:NTE_00110"/>
    <dbReference type="eggNOG" id="arCOG01917">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG03713">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG04276">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000404_2_3_2"/>
    <dbReference type="UniPathway" id="UPA00326"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02888">
        <property type="entry name" value="RNR_II_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.70.20:FF:000022">
        <property type="entry name" value="Vitamin B12-dependent ribonucleotide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.70.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013346">
        <property type="entry name" value="NrdE_NrdA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050862">
        <property type="entry name" value="RdRp_reductase_class-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000788">
        <property type="entry name" value="RNR_lg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013509">
        <property type="entry name" value="RNR_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013344">
        <property type="entry name" value="RNR_NrdJ/NrdZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008926">
        <property type="entry name" value="RNR_R1-su_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02506">
        <property type="entry name" value="NrdE_NrdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02504">
        <property type="entry name" value="NrdJ_Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43371:SF1">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43371">
        <property type="entry name" value="VITAMIN B12-DEPENDENT RIBONUCLEOTIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03477">
        <property type="entry name" value="ATP-cone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02867">
        <property type="entry name" value="Ribonuc_red_lgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00317">
        <property type="entry name" value="Ribonuc_red_lgN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01183">
        <property type="entry name" value="RIBORDTASEM1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51998">
        <property type="entry name" value="PFL-like glycyl radical enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48168">
        <property type="entry name" value="R1 subunit of ribonucleotide reductase, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 13" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="10 13" id="KW-0170">Cobalt</keyword>
    <keyword evidence="8" id="KW-0215">Deoxyribonucleotide synthesis</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="5 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 13 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-cone" evidence="14">
        <location>
            <begin position="52"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AIF82192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="950" mass="106634" checksum="974ABA2D37C3060E" modified="2014-10-29" version="1">MPWPGLIVNCAFLLMYEITQIAQKSISTSGLVVRDGMAGVTEFNNSQGNLISKIRKRDGRIVSFEQSKISNAIYKALVATGKPDYPLAERLGVRVFQKMAQQGYGSEKAVATVEDVQDMVESILIEEGLSETAKAYILYRHERRKVRDEKMKVLNKKDLDEVDKAFDINSLRVLAARYLLRDENNEIVESPKQMFERVAILVGIADVMHDSQVFNLAGGHVQDAEEAAKYYHKLADFDMKLKIGEYWLNRYHFEAMVRSYIHAAKQGQMKVSFKELLRLVAEGKMAAYSDRIREYYNLMISRDFLPNTPTLMNAGARLGQLSACFVLDMPDDMNRIMKSSTDAAMIFKSGGGVGINYSDLRPEGDIVASTSGVASGPTSFMRIIDTITDVVKQGGKRRGANMGILEAWHPDVEKFVTAKTKPGVFENFNVSVGIWEDFWKALVSKDGNHKYTLRNPRTHEPMRQIDAQQLIDLIALSAWKSAEPGVIFFDNINKYNPCIEAKGGPLRATNPCGEQSLYPYESCNLGSINLANFVKRKADGMYEFDWQRYEQAVRLSTRFLDNIIDMNKYPVEEIETNTRATRRIGLGIMGIADLLFLLRISYNSKDGYEFMNKLAEAVSYLSMDESVAIAKSRGPFPMFKDTDYVKGRIPVAGYYELPKETHTYDWATLIEKIKKNGIRNSWTSTIAPTGTLSMIADTANGVEPVFALVFEKRVTVGRFFYTDKVFENALKENGLYSDEILTKIANNYGSVRGIAEIPEWMQRTFVTAIDIHWMDHIMAQAVWQKWISNAIAKTINMPGDVTAEDVKCSYLLSHELGLKGVTVFRDGSRQEQVLHITGKNNGEKQFTVKPSRYIADYIQNNIQEPYVREQMLKILKEKGIDEGTVPQATMATAAVAAPVVEVPKKATQPAAMQVMSSNEDTTCPSCKARLVITEGCNICIECGFSSCASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MN29</accession>
    <name>A0A075MN29_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MN29"/>
    <dbReference type="STRING" id="1459636.NTE_00840"/>
    <dbReference type="KEGG" id="nev:NTE_00840"/>
    <dbReference type="HOGENOM" id="CLU_156997_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="133" mass="15640" checksum="986ACAD2469D92FD" modified="2014-10-29" version="1">MHPFRLYGTRYNRNLILAQNSFPMREWHVKHMEKTVVKYVGGLAPNASAWEKKNHKRYVSFSNICRQIDYDIKHGVTNEQVVSFLNKVRHDTSFSKVRGNDGSLDRLTEVEKHFHETVSSLGGKKRRRELLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MN50</accession>
    <name>A0A075MN50_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MN50"/>
    <dbReference type="KEGG" id="nev:NTE_00880"/>
    <dbReference type="HOGENOM" id="CLU_201545_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="73" mass="7650" checksum="90C1C32C8A4FDD5A" modified="2014-10-29" version="1">MGKINGENVAGAAFLLFASVFLAAGMVNPIIASVAVVFYFLAAAGVALVFLGYRTHRNEILSSGTTAVQQQHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MN67</accession>
    <name>A0A075MN67_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TATA-box-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Box A-binding protein</fullName>
            <shortName evidence="7">BAP</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">TATA sequence-binding protein</fullName>
            <shortName evidence="7">TBP</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">TATA-box factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tbp</name>
        <name evidence="9" type="ORF">NTE_00618</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7 8">General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the TBP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MN67"/>
    <dbReference type="STRING" id="1459636.NTE_00618"/>
    <dbReference type="KEGG" id="nev:NTE_00618"/>
    <dbReference type="eggNOG" id="arCOG01764">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060161_4_3_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000007">
        <property type="entry name" value="TATA-box-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000010">
        <property type="entry name" value="TATA-box-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00408">
        <property type="entry name" value="TATA_bind_prot_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000814">
        <property type="entry name" value="TBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030491">
        <property type="entry name" value="TBP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10126">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00352">
        <property type="entry name" value="TBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00686">
        <property type="entry name" value="TIFACTORIID"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00351">
        <property type="entry name" value="TFIID"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 7 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="repeat" description="1" evidence="7">
        <location>
            <begin position="24"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="repeat" description="2" evidence="7">
        <location>
            <begin position="115"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF82698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="201" mass="22203" checksum="810CC39BF53CC7CA" modified="2014-10-29" version="1">MASRYIYRPFIKGSVPQTKPIVSIENVVASATVNQTVNLNLITQIFPDVEYHPDQFPGLVFRLRSPKTATLIFSSGKMVCTGAKSEKMAIQAVKNVVQKLKKGGIPLENEPQIEIQNIVASASLGGKIHLELAARVLPRSMYEPEQFPGLIHRMLDPKTVILLFASGKLVCTGAKKESEVYRAVGNLHTLLEEKNLMIYEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNF7</accession>
    <name>A0A075MNF7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable porphobilinogen deaminase</fullName>
            <shortName evidence="4">PBG</shortName>
            <ecNumber evidence="4">2.5.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Hydroxymethylbilane synthase</fullName>
            <shortName evidence="4">HMBS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Pre-uroporphyrinogen synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hemC</name>
        <name evidence="7" type="ORF">NTE_01012</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>4 porphobilinogen + H2O = hydroxymethylbilane + 4 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57845"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="EC" id="2.5.1.61"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>dipyrromethane</name>
            <dbReference type="ChEBI" id="CHEBI:60342"/>
        </cofactor>
        <text evidence="4">Binds 1 dipyrromethane group covalently.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="4">The porphobilinogen subunits are added to the dipyrromethane group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the HMBS family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.61" evidence="4"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699919.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNF7"/>
    <dbReference type="STRING" id="1459636.NTE_01012"/>
    <dbReference type="GeneID" id="41596836"/>
    <dbReference type="KEGG" id="nev:NTE_01012"/>
    <dbReference type="eggNOG" id="arCOG04299">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019704_0_2_2"/>
    <dbReference type="OrthoDB" id="8042at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004418">
        <property type="term" value="F:hydroxymethylbilane synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13644">
        <property type="entry name" value="PBP2_HemC_archaea"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000005">
        <property type="entry name" value="Porphobilinogen deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.40">
        <property type="entry name" value="Porphobilinogen deaminase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00260">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000860">
        <property type="entry name" value="HemC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022417">
        <property type="entry name" value="Porphobilin_deaminase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022418">
        <property type="entry name" value="Porphobilinogen_deaminase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036803">
        <property type="entry name" value="Porphobilinogen_deaminase_C_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00212">
        <property type="entry name" value="hemC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557">
        <property type="entry name" value="PORPHOBILINOGEN DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557:SF0">
        <property type="entry name" value="PORPHOBILINOGEN DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01379">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03900">
        <property type="entry name" value="Porphobil_deamC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001438">
        <property type="entry name" value="4pyrrol_synth_OHMeBilane_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00151">
        <property type="entry name" value="PORPHBDMNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54782">
        <property type="entry name" value="Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Porphobilinogen deaminase N-terminal" evidence="5">
        <location>
            <begin position="5"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Porphobilinogen deaminase C-terminal" evidence="6">
        <location>
            <begin position="225"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="modified residue" description="S-(dipyrrolylmethanemethyl)cysteine" evidence="4">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF83086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="315" mass="34299" checksum="6EFDE4F86AEFF866" modified="2014-10-29" version="1">MKTIIKVGTRGSRLAVAQTELALAALRKAHPGAKFEVVMISTKGDVDRRPLFTMDEKGIFEKEVNEAVKKGEVDFAVHSLKDIPSDLSEELTVACIPRRASPNDVLVNEKGQKLQELAAGSVVGTSSLRRAIQLMKERPDISVKPIRGNVETRVKKVISGEFDAVVLAEAGLTRIGMKDVIVERFGVREFVPAPGQGAIAIVCRRNDKKTIEMLRSIEDPRARAEVTAERALIEKVEGGCRFPLGAVAVTKGDRITLYASVFSADGSRNIKVKKTGSAKSAEKLGKSVADLLVKQGAQEMAEGWRRAVEEWNKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNH8</accession>
    <name>A0A075MNH8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mannose-6-phosphate isomerase, type 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699361.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNH8"/>
    <dbReference type="STRING" id="1459636.NTE_00280"/>
    <dbReference type="GeneID" id="41596188"/>
    <dbReference type="KEGG" id="nev:NTE_00280"/>
    <dbReference type="eggNOG" id="arCOG02427">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035527_4_3_2"/>
    <dbReference type="OrthoDB" id="5825at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004475">
        <property type="term" value="F:mannose-1-phosphate guanylyltransferase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005976">
        <property type="term" value="P:polysaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02213">
        <property type="entry name" value="cupin_PMI_typeII_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001538">
        <property type="entry name" value="Man6P_isomerase-2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051161">
        <property type="entry name" value="Mannose-6P_isomerase_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46390">
        <property type="entry name" value="MANNOSE-1-PHOSPHATE GUANYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46390:SF1">
        <property type="entry name" value="MANNOSE-1-PHOSPHATE GUANYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01050">
        <property type="entry name" value="MannoseP_isomer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mannose-6-phosphate isomerase type II C-terminal" evidence="1">
        <location>
            <begin position="6"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="112" mass="12834" checksum="DD236C63655B0BB6" modified="2014-10-29" version="1">MISTETRPWGHFERFTLNEPCTVKLVYVDGDKRLSLQYHNNRSEFWKVVKGPVKVQIGEEKKLLQTGDTITIPKGTVHRLEGAGTDAIILEISKGDFDETDIVRIEDDYKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNK0</accession>
    <name>A0A075MNK0_9ARCH</name>
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        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158384946.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNK0"/>
    <dbReference type="STRING" id="1459636.NTE_00305"/>
    <dbReference type="GeneID" id="43502552"/>
    <dbReference type="KEGG" id="nev:NTE_00305"/>
    <dbReference type="HOGENOM" id="CLU_3038865_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="54" mass="6178" checksum="55EDEF7C742EBE19" modified="2014-10-29" version="1">MQQVLLPTKCSYCDILLEGREQFVGHMIHSHELPIAQAEEMWESSVSARMCRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNN4</accession>
    <name>A0A075MNN4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNN4"/>
    <dbReference type="KEGG" id="nev:NTE_00340"/>
    <dbReference type="HOGENOM" id="CLU_2103381_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="115" mass="13315" checksum="DFD27108EDF6D37A" modified="2014-10-29" version="1">MDANRDVVAALFMEDGELTAWRGRDDVALPPDDKVKDLLFHRFLINALLGTRKEYVGKVHFNLTRYDLIDIVHFGWFSAEKEVILVVMMSKSANTLEEIEKLQTLITRWKSMSET</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNQ4</accession>
    <name>A0A075MNQ4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Delta-aminolevulinic acid dehydratase</fullName>
            <ecNumber evidence="10">4.2.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NTE_00765</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 10">
            <text>2 5-aminolevulinate = porphobilinogen + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="4.2.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ALAD family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.24" evidence="10"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699736.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNQ4"/>
    <dbReference type="STRING" id="1459636.NTE_00765"/>
    <dbReference type="GeneID" id="41596617"/>
    <dbReference type="KEGG" id="nev:NTE_00765"/>
    <dbReference type="eggNOG" id="arCOG04300">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035731_0_0_2"/>
    <dbReference type="OrthoDB" id="8493at2157"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004655">
        <property type="term" value="F:porphobilinogen synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001731">
        <property type="entry name" value="ALAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030656">
        <property type="entry name" value="ALAD_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006762">
        <property type="entry name" value="PRK09283.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458">
        <property type="entry name" value="DELTA-AMINOLEVULINIC ACID DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458:SF0">
        <property type="entry name" value="DELTA-AMINOLEVULINIC ACID DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00490">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001415">
        <property type="entry name" value="Porphbilin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00144">
        <property type="entry name" value="DALDHYDRTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01004">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00169">
        <property type="entry name" value="D_ALA_DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="4 10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="7">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="7">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIF82843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="317" mass="34040" checksum="E1AE6B6ADD2C3E66" modified="2014-10-29" version="1">MQAHAYADTLSLAGLKREHLICPVFVSEKQEEGGGSIAAMPGISISPFKDAVLSVQKIFDAGIRSIIVFGIPKSRDGDGSAAADRSGVVQRATREIKSAFGRSLDVITDVCVCQYNLSGHCGLVRNNSGTVDNDSTLEVLAEISQSHAEAGADIVAPSAMMDGQVRAIRSALDKNGHYATRILSYSAKHASSLYTPFRSAAFAKKNGAIDKAGYQVSFANPKQAIREIAGDIEEGADMVMVKPGLAYLDLVRRAKERFSVPVAVQNVSGEYAMIKAAGMMGWIDEEQWKITSLAAMRRAGADRIISYFALDVARYLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNR8</accession>
    <name>A0A075MNR8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNR8"/>
    <dbReference type="KEGG" id="nev:NTE_00375"/>
    <dbReference type="HOGENOM" id="CLU_3408317_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="29" mass="3146" checksum="D96B6624D4B2D794" modified="2014-10-29" version="1">MLESALNEAFGKAPAFFITDSLVSLECKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNU5</accession>
    <name>A0A075MNU5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">FUN14 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NTE_00727</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FUN14 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699704.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNU5"/>
    <dbReference type="STRING" id="1459636.NTE_00727"/>
    <dbReference type="GeneID" id="41596579"/>
    <dbReference type="KEGG" id="nev:NTE_00727"/>
    <dbReference type="eggNOG" id="arCOG04811">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095425_1_2_2"/>
    <dbReference type="OrthoDB" id="12055at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007014">
        <property type="entry name" value="FUN14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21346">
        <property type="entry name" value="FUN14 DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21346:SF10">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04930">
        <property type="entry name" value="FUN14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF82805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="112" mass="11230" checksum="2DC7EAB4CE2B59BA" modified="2014-10-29" version="1">MSVDFTSVAASVGVGGVAGFVMGYAIKKILKIVMVIVGLFLAALAYLASQNVITINWDKIGAASTSTLVGLQNATIGATPGAADQVMMAMANIGIPLTGSFAAAFALGFMKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MP84</accession>
    <name>A0A075MP84_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Potassium-transporting ATPase ATP-binding subunit</fullName>
            <ecNumber evidence="16">7.2.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">ATP phosphohydrolase [potassium-transporting] B chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Potassium-binding and translocating subunit B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Potassium-translocating ATPase B chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">kdpB</name>
        <name evidence="18" type="ORF">NTE_00942</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system and for the release of the potassium ions to the cytoplasm.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>K(+)(out) + ATP + H2O = K(+)(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16777"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="16">The system is composed of three essential subunits: KdpA, KdpB and KdpC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Cell membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.6" evidence="16"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699870.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MP84"/>
    <dbReference type="STRING" id="1459636.NTE_00942"/>
    <dbReference type="GeneID" id="41596777"/>
    <dbReference type="KEGG" id="nev:NTE_00942"/>
    <dbReference type="eggNOG" id="arCOG01577">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025728_2_0_2"/>
    <dbReference type="OrthoDB" id="8588at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00285">
        <property type="entry name" value="KdpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006391">
        <property type="entry name" value="P-type_ATPase_bsu_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43743">
        <property type="entry name" value="POTASSIUM-TRANSPORTING ATPASE ATP-BINDING SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43743:SF1">
        <property type="entry name" value="POTASSIUM-TRANSPORTING ATPASE ATP-BINDING SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 16" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14 16" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 16" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11 16" id="KW-0630">Potassium</keyword>
    <keyword evidence="4 16" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 16" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 16" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="223"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="656"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="696"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="17">
        <location>
            <begin position="117"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="16">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="381"/>
            <end position="388"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="437"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="558"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="562"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="AIF83018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="721" mass="77706" checksum="78B2A7B9C19086C1" modified="2014-10-29" version="1">MSKNNSIRTEKKARGKKGSAVSGRVILDSITKMSPYYLAKNSPVMFAVEVGFFLVLAIAVFPDISKEYVNQSRTFYIESAVILILTVWFATFSESLSEAQARARVDSLRSLEKEVPARKWANNKETMVTSTILKPGDEVMVHAGEVIPRDGLVNEGKAFVDESMMTGESNPVFKEKGDRVIGGTRVASDKLLIEITSEMGRSFLDQMVGLIESATRPKTKNEIALTILLAGLSIIFVMVIGTLLFFARFLGYPVDIATLVALLVALMPTTIGALLPAIGVAGITRLGRDNIIAKSGKGIEAAGDCDVLVLDKTGTITEGSRSAVAFVPMQGFTEEDIGQAAFAASIHDTTHEGKSIIDLAEAKKFVPPLLEKIITARPIEFSAETRYSGIELIPSKRATLEKMETVKSFNGPVSSGCKVAAMLQEISRTNRNAKILKGSIDAMLSTAGNNLNEAELKWKCQEVSKTGGTPLIVMIDKTAVGLVALKDNLKENIRQKLDEVRATGISTVMITGDNRLTAEVIAREANVDQVIAEAKPTDKLRKVEEEQGRGHVIGMVGDGTNDAPALAKADVGLAMNSGTAAAKEAANMVDLDSDPSKILKVVKLGKQLLMTRGAITTFSIANDVAKYFALLPAMFMESNPKMQALNIMQLHSAETAVLSTLIFNAIIIPLLIPLALKGTRFKPEPPQKTFVRNMLIYGIGGAVLPFAAIKGIDILLSLFMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MP95</accession>
    <name>A0A075MP95_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein, MTH1187 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_01297</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0045 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700151.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MP95"/>
    <dbReference type="STRING" id="1459636.NTE_01297"/>
    <dbReference type="GeneID" id="41597100"/>
    <dbReference type="KEGG" id="nev:NTE_01297"/>
    <dbReference type="eggNOG" id="arCOG04373">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_137479_3_1_2"/>
    <dbReference type="OrthoDB" id="10763at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029756">
        <property type="entry name" value="MTH1187/YkoF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002767">
        <property type="entry name" value="Thiamine_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051614">
        <property type="entry name" value="UPF0045_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00106">
        <property type="entry name" value="MTH1187 family thiamine-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33777">
        <property type="entry name" value="UPF0045 PROTEIN ECM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33777:SF1">
        <property type="entry name" value="UPF0045 PROTEIN ECM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01910">
        <property type="entry name" value="Thiamine_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89957">
        <property type="entry name" value="MTH1187/YkoF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thiamine-binding protein" evidence="2">
        <location>
            <begin position="5"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF83366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="101" mass="10713" checksum="30FEE04AD3BDABB1" modified="2014-10-29" version="1">MTVHAEISVIPVTGSTSMSREVAVAFDAIKKTQGIRVTLTALGTQMEAEDISAVLAAIKAAHGAVKKAGVARIISSVRIDERLDKDQSLESKVRAVKKRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPA9</accession>
    <name>A0A075MPA9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_01313</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPA9"/>
    <dbReference type="STRING" id="1459636.NTE_01313"/>
    <dbReference type="KEGG" id="nev:NTE_01313"/>
    <dbReference type="eggNOG" id="arCOG08812">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034350_1_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="472"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF83381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="501" mass="54300" checksum="9B9C893008CE1F13" modified="2014-10-29" version="1">MLLFFHSITIKYAICGVERVNTGRGKLVALAFIAVLVLPTVLASQKAFADGLTQENLPPASFGDQQASLFVKINPPILTTESKQDAYLQFRLFDAKTNETIKFPTLNIAVYKGTDPNAKPLMQDFFQSENGLLTIKVKPQEGDVQVQGNREPFLNALKADPGGTVNISGPVLLDGGLYRIDVSVFGIKYPTNIFKDEDVKTFETALSVGDVYSQNVQSEGKTYPMSIISYYDKVEDFKFNAASKTYSWAMPFNWNTSRIQNAPNVFVHEEVRVPKSFTGVGDASAFDAKVNGKPIAGRMLAVDPFSDENNLILHFLINKNDILDMARNSPPSDGKMSFSFSPAGASEGQQTSGEISTDTGGIHALLNWTPGQLKAGAETKLDIQFVDAFAGTNISDQDVKYDLKIFDKNGKEVLAKTDQTAQGGKGEQAGLNFPADDTYRVEITVNGLVKQGQSPDLTRNGIARGIVVVPEFPAGAMVAVAGAIGAIVVAQRLMTTARKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPF0</accession>
    <name>A0A075MPF0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01019</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPF0"/>
    <dbReference type="STRING" id="1459636.NTE_01019"/>
    <dbReference type="KEGG" id="nev:NTE_01019"/>
    <dbReference type="HOGENOM" id="CLU_2393001_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="99" mass="10573" checksum="7427AA49C49786E2" modified="2014-10-29" version="1">MVVTTTAAEERPPAFVSRSSTAAREKPFARANFLVCNSCLWCASGLGPATRIDRCPGCGAEGMVEALPILSNETYRVKKKAGDRGVELDFTTTTTTTLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPW0</accession>
    <name>A0A075MPW0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00814</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPW0"/>
    <dbReference type="STRING" id="1459636.NTE_00814"/>
    <dbReference type="KEGG" id="nev:NTE_00814"/>
    <dbReference type="HOGENOM" id="CLU_1987510_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="125" mass="14158" checksum="CD79F7BCEBAA1937" modified="2014-10-29" version="1">MGAEIPLFFSAHMCLALQPNFRHEIDSNMPSSYSIVSINARPAQESGAQLFQSSSDTLQAHIKMQCRFSNCCRYYNKDDHRCKDDQDVMTISSCAAAWQFDRYARGDKDIGMNVANIFIIKIHNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQG1</accession>
    <name>A0A075MQG1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">methylated-DNA--[protein]-cysteine S-methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.63</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NTE_01386</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a thymidine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:53428"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:13555"/>
            <dbReference type="Rhea" id="RHEA-COMP:13556"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:137386"/>
            <dbReference type="ChEBI" id="CHEBI:137387"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] = S-methyl-L-cysteinyl-[protein] + a 2'-deoxyguanosine in DNA</text>
            <dbReference type="Rhea" id="RHEA:24000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:11367"/>
            <dbReference type="Rhea" id="RHEA-COMP:11368"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:85445"/>
            <dbReference type="ChEBI" id="CHEBI:85448"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MGMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.63" evidence="3"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700223.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQG1"/>
    <dbReference type="STRING" id="1459636.NTE_01386"/>
    <dbReference type="GeneID" id="41597182"/>
    <dbReference type="KEGG" id="nev:NTE_01386"/>
    <dbReference type="eggNOG" id="arCOG02724">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_52_5_2"/>
    <dbReference type="OrthoDB" id="372118at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003908">
        <property type="term" value="F:methylated-DNA-[protein]-cysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000214">
        <property type="entry name" value="Methylated-DNA--protein-cysteine methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001497">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00589">
        <property type="entry name" value="ogt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10815">
        <property type="entry name" value="METHYLATED-DNA--PROTEIN-CYSTEINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10815:SF13">
        <property type="entry name" value="METHYLATED-DNA--PROTEIN-CYSTEINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="Methylated DNA-protein cysteine methyltransferase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00374">
        <property type="entry name" value="MGMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding" evidence="9">
        <location>
            <begin position="10"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIF83453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="110" mass="12117" checksum="4A9F56EC15AADDD1" modified="2014-10-29" version="1">MKTGRRLDAKDVYDLLRTVPEGQVTTYGDLAKALGFPRAARAIGRIMNANPDPIVVPCHRVVASDGGIGGYGFGIKMKKEILTKEGLLFDGDMIVDFEKKRAVLKLKRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQM2</accession>
    <name>A0A075MQM2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">threonine ammonia-lyase</fullName>
            <ecNumber evidence="3">4.3.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NTE_01317</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.19" evidence="3"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700166.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQM2"/>
    <dbReference type="STRING" id="1459636.NTE_01317"/>
    <dbReference type="GeneID" id="41597119"/>
    <dbReference type="KEGG" id="nev:NTE_01317"/>
    <dbReference type="eggNOG" id="arCOG01431">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021152_4_1_2"/>
    <dbReference type="OrthoDB" id="9915at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:threonine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006565">
        <property type="term" value="P:L-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04886">
        <property type="entry name" value="ACT_ThrD-II-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01562">
        <property type="entry name" value="Thr-dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000007">
        <property type="entry name" value="L-threonine dehydratase catabolic TdcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044561">
        <property type="entry name" value="ACT_ThrD-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050147">
        <property type="entry name" value="Ser/Thr_Dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005789">
        <property type="entry name" value="Thr_deHydtase_catblc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01127">
        <property type="entry name" value="ilvA_1Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078:SF6">
        <property type="entry name" value="L-THREONINE DEHYDRATASE CATABOLIC TDCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="6">
        <location>
            <begin position="342"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF83385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="417" mass="44704" checksum="0842EE8D2CBF48AB" modified="2014-10-29" version="1">MNDDSVWKADRKHKVPTYDDIVRARRLLEGTVRKTPLQRSNTFSKLAGTNVFLKLECLQLTGSFKVRGALAKVGSLTEKQAGYGVIAASAGNHAQGVAYASARKNVPCTIVMPQNASPAKVAATRSYGAEVIQKGFNYDEAWEATQEIAKQEGKTIIHAFDDPDVIAGQGTIGLELLEDIADADRIYLPVGGGGLAAGVSIAIKAKKPDIKIIGVESRAFPAMKESMAKGSLQSVKAGYTIADGISVKSPGKLTYEIVSKHLDDIVLVDDSAIVKTMFLLMERAKLVVEPAGAASLAYLLSNGHPAGKNEKVVSLLSGGNVDMYLLGQVVAKGLMQMGRLVKIFILLPDKPGALKEVVDDIAELSVNIVEVEHDRLSANIPAGTAGVYLSLELENEKRSQKLLDYMKRKGIEFKVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQP0</accession>
    <name>A0A075MQP0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">2-phospho-L-lactate guanylyltransferase</fullName>
            <shortName evidence="5">LP guanylyltransferase</shortName>
            <ecNumber evidence="5">2.7.7.68</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">cofC</name>
        <name evidence="6" type="ORF">NTE_01464</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Guanylyltransferase that catalyzes the activation of (2S)-2-phospholactate (2-PL) as (2S)-lactyl-2-diphospho-5'-guanosine, via the condensation of 2-PL with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(2S)-2-phospholactate + GTP + H(+) = (2S)-lactyl-2-diphospho-5'-guanosine + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:63424"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:59435"/>
            <dbReference type="ChEBI" id="CHEBI:59906"/>
            <dbReference type="EC" id="2.7.7.68"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; coenzyme F420 biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CofC family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.68" evidence="5"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385211.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQP0"/>
    <dbReference type="STRING" id="1459636.NTE_01464"/>
    <dbReference type="GeneID" id="41597257"/>
    <dbReference type="KEGG" id="nev:NTE_01464"/>
    <dbReference type="eggNOG" id="arCOG04472">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076569_1_1_2"/>
    <dbReference type="OrthoDB" id="11179at2157"/>
    <dbReference type="UniPathway" id="UPA00071"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043814">
        <property type="term" value="F:phospholactate guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052645">
        <property type="term" value="P:F420-0 metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02114">
        <property type="entry name" value="CofC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002835">
        <property type="entry name" value="CofC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03552">
        <property type="entry name" value="F420_cofC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40392">
        <property type="entry name" value="2-PHOSPHO-L-LACTATE GUANYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40392:SF1">
        <property type="entry name" value="2-PHOSPHO-L-LACTATE GUANYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01983">
        <property type="entry name" value="CofC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 5 6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF83528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="227" mass="24573" checksum="800377AD559239F4" modified="2014-10-29" version="1">MTTTKTKTTIIAIIPVKKFENSKSRLSAVLSVQDRVRLAGLMLQDTLATLDRCKLLAEIVVVSSDERAGEIARKYGATVLFQAQDAGVNSAVAVADRYAVQKKNAGATIVIPQDLPLLGAGDVDGICSAAAGRCIVICPSLRYDGTNLLLRMPADVISTSYDNNSYESHIVSARAQHAAVRVIEQEHLMFDIDTQEDARQLAQMDPRLVVAKNVALFLKEKALLSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQS4</accession>
    <name>A0A075MQS4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01372</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQS4"/>
    <dbReference type="KEGG" id="nev:NTE_01372"/>
    <dbReference type="eggNOG" id="arCOG08733">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_941990_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="295" mass="33084" checksum="775F7C910DBB4777" modified="2014-10-29" version="1">MMTLITQVQKLFARIMRQPIMTLFLFVALLLLLLLKPASIFAQGKIDVTSSPAYFGNLPSALAASDNNNSASADNTWYIGKGTKPDTYVKYAINNLGTNNNQTFIMTIYFKDYNVTGKYWIAPVYIFDAPNKENNIDAGRFPHLVNGTFLLNDETMRVIQGSDIPQQLAQYKDAYGYSLDWLSDFATKSSPRSLSQPSWGKAASLGGIEIWLKSTETLTVPAGTFNTTVITWHKGAAASDSKIWVNKDFPYPIKARVYSEVIHPPAPIWFEFELLEYGKGSLLNRWQSSDYLTLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQT4</accession>
    <name>A0A075MQT4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase family M50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700316.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQT4"/>
    <dbReference type="STRING" id="1459636.NTE_01505"/>
    <dbReference type="GeneID" id="41597294"/>
    <dbReference type="KEGG" id="nev:NTE_01505"/>
    <dbReference type="HOGENOM" id="CLU_142654_0_0_2"/>
    <dbReference type="OrthoDB" id="9290at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="155" mass="16515" checksum="BC281027D47EFEAC" modified="2014-10-29" version="1">MRLNRSVIQWSVILYIALVIPVSLLHETGHALVCSASGFDYSLWIDGTGGHMVCAHTPSNSVAYGAMGGLFGLMGSAAIIGFWAAAKRHPAVLVVGLAYAVDQAAKLILEGFFTPLYASGATDLFLTALQLVSWIGLTIYFARTPKIQAVTSRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQV1</accession>
    <name>A0A075MQV1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0215 protein NTE_01410</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0215 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987207.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQV1"/>
    <dbReference type="STRING" id="1459636.NTE_01410"/>
    <dbReference type="GeneID" id="41597203"/>
    <dbReference type="KEGG" id="nev:NTE_01410"/>
    <dbReference type="eggNOG" id="arCOG00928">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095956_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2170.10">
        <property type="entry name" value="archaeoglobus fulgidus dsm 4304 superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00582">
        <property type="entry name" value="UPF0215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002802">
        <property type="entry name" value="Endo_dU"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39518">
        <property type="entry name" value="UPF0215 PROTEIN MJ1150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39518:SF2">
        <property type="entry name" value="UPF0215 PROTEIN MJ1150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01949">
        <property type="entry name" value="Endo_dU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006380">
        <property type="entry name" value="UCP006380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="179" mass="19461" checksum="7A6EE2145D186FBA" modified="2014-10-29" version="1">MRVFAIAESFRKAAKSSVLAGVVMRRDLVIDGMAFGRATVGGDDATGAIVSMYASLGRDDVNCILLDGLVISMYNIIDGEQVMQGTGLPVIAITFEDSKGLEGAIRHHFQQGWEEKVEKYRRLGVRERVTLKTGKALYTRCWGITQKRATAVLNAFTLQGALPEPIKVAKISARSALSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQZ9</accession>
    <name>A0A075MQZ9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Restriction endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01466</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700287.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQZ9"/>
    <dbReference type="GeneID" id="41597259"/>
    <dbReference type="KEGG" id="nev:NTE_01466"/>
    <dbReference type="eggNOG" id="arCOG03727">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107015_0_0_2"/>
    <dbReference type="OrthoDB" id="31536at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007560">
        <property type="entry name" value="Restrct_endonuc_IV_Mrr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04471">
        <property type="entry name" value="Mrr_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Restriction endonuclease type IV Mrr" evidence="1">
        <location>
            <begin position="83"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="218" mass="23357" checksum="23EDCE0B118AA25F" modified="2014-10-29" version="1">MHPELLVKALAAMSQDTTTLDQFCHKAGIASRSVARSLAEGLLARGIGRGSASAIMSFSPGDRLATAALALDAGCDPERVSQHLTWKDFEQLAAGVLASLGYRTRTNVRFTKPRMELDVVGTSAAGLALAVDCKHWKKGGLSSISQHCAKQAKRTEELLRRESEISMAVPVVMTLHAANVRLVGGMPVVPVAKFHSFAMDVSGFLDEVLVFTREPASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MR16</accession>
    <name>A0A075MR16_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative Fe-S oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NTE_01185</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700052.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MR16"/>
    <dbReference type="STRING" id="1459636.NTE_01185"/>
    <dbReference type="GeneID" id="41596995"/>
    <dbReference type="KEGG" id="nev:NTE_01185"/>
    <dbReference type="eggNOG" id="arCOG00938">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_881677_0_0_2"/>
    <dbReference type="OrthoDB" id="5620at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050377">
        <property type="entry name" value="Radical_SAM_PqqE_MftC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11228:SF7">
        <property type="entry name" value="PQQA PEPTIDE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11228">
        <property type="entry name" value="RADICAL SAM DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01067">
        <property type="entry name" value="SPASM/twitch_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="35"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF83257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="321" mass="36862" checksum="C8EE325F5CECFD4A" modified="2014-10-29" version="1">MVDIIYGRGFTDLAREMPFYISIFKKIIAYRLFKSKQPMYGSVDVNNICNLHCTHCYWWLNRKEGEDLTAEDWRKIIKEKINKNHLFVVTLVGGEPTMRPDVIQTFCEEMPRRVCVVTNATFPLKRFDNLYFYWVSMDGTEKIHDMIRGKGSYAKTKQNILDYIAGPDRQGKAAWRDIWITMTINSQNYMTVEDLTEEWRGKVNKIGFQFHTPFAKGDPLFMPFGEKRSEVVDKIIALKKKYPDFVINSPKQISLMKGNWGGIGTTPVDCPSWAIMSFDHMGRIKMPCCIGSADPKAQKPLCEECGLGCYSILVAQGIVGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MR63</accession>
    <name>A0A075MR63_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
            <ecNumber evidence="9">1.3.8.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NTE_01522</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.7" evidence="9"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MR63"/>
    <dbReference type="STRING" id="1459636.NTE_01522"/>
    <dbReference type="KEGG" id="nev:NTE_01522"/>
    <dbReference type="eggNOG" id="arCOG01707">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_0_2_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070991">
        <property type="term" value="F:medium-chain fatty acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF12">
        <property type="entry name" value="ISOVALERYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="8">
        <location>
            <begin position="8"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="7">
        <location>
            <begin position="121"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="6">
        <location>
            <begin position="225"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="6">
        <location>
            <begin position="339"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF83585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="411" mass="44894" checksum="36547BF3F9D34200" modified="2014-10-29" version="1">MNFNVSKKQQEFLGSVDAACREIRPYEDEAYLAEKLNEMVVPVFGRIGMTGCPISKKYGGLGLDMLTYALAIERIGQEGSSLRTFFSAHTSIGQLVLQGWGSEEQKKEYLPDTTSGKKAMAFALTEPAAGSDPAAMTTTFEETSEGFVLKGKKHWIGNGTFAGVMTTYAKDPSTGRVSAFIVDGDAKGLSTKEMKNKMGLLTVKNAEINFDRCMVPKKNLLGKKGQGLSIAYSALIDGRLSVAAGAAGVMEDCLAEAAAYAKSRHQHGGPLAKKQLIQEHIARIAVDIESSHWLVYRAAAARQRLHEYVEGLKKENGAKWLDRLGRQNGEYTMLRAETDRLAAIAKFHASNRSFECANRSVQVFGSAGYKKTARVARHFLDSRATMIYEGANEVLELKIASEVLGDEYAAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRM7</accession>
    <name>A0A075MRM7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02142</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700812.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRM7"/>
    <dbReference type="GeneID" id="41597867"/>
    <dbReference type="KEGG" id="nev:NTE_02142"/>
    <dbReference type="HOGENOM" id="CLU_2165141_0_0_2"/>
    <dbReference type="OrthoDB" id="11601at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="110" mass="11575" checksum="F62FE47973F78F33" modified="2014-10-29" version="1">MSSSGMDDILPAEKIAFIAYNVGVYESVQKFGSLITSGKISGATDAAKVAELLAETGAFYDSEMISQLINSMIRSRGRTGETSTTIGSITAANVEYVMKQLKVAGVSLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRS6</accession>
    <name>A0A075MRS6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01807</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRS6"/>
    <dbReference type="KEGG" id="nev:NTE_01807"/>
    <dbReference type="HOGENOM" id="CLU_2270919_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="102" mass="11086" checksum="B635C973779CF544" modified="2014-10-29" version="1">MPFKFQTDFGMFQTTIGIIIGIGIALVSFGFTTAANILQGLITLDPQTTPARVYLGLEALSTLGLFWGVSGAIVFAGGIFLFVWKRKSFYERARRLDGDASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRU6</accession>
    <name>A0A075MRU6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Exopolyphosphatase</fullName>
            <ecNumber evidence="2">3.6.1.11</ecNumber>
            <ecNumber evidence="2">3.6.1.40</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.1.11" evidence="2"/>
    <dbReference type="EC" id="3.6.1.40" evidence="2"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699196.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRU6"/>
    <dbReference type="STRING" id="1459636.NTE_00050"/>
    <dbReference type="GeneID" id="41596001"/>
    <dbReference type="KEGG" id="nev:NTE_00050"/>
    <dbReference type="eggNOG" id="arCOG05138">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025908_4_2_2"/>
    <dbReference type="OrthoDB" id="10802at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004309">
        <property type="term" value="F:exopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008894">
        <property type="term" value="F:guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24052">
        <property type="entry name" value="ASKHA_NBD_HpPPX-GppA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.150">
        <property type="entry name" value="Exopolyphosphatase. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050273">
        <property type="entry name" value="GppA/Ppx_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003695">
        <property type="entry name" value="Ppx_GppA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30005">
        <property type="entry name" value="EXOPOLYPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30005:SF0">
        <property type="entry name" value="RETROGRADE REGULATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02541">
        <property type="entry name" value="Ppx-GppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ppx/GppA phosphatase N-terminal" evidence="1">
        <location>
            <begin position="22"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="521" mass="57540" checksum="59B98C1858AFDB6E" modified="2014-10-29" version="1">MKVSVVDLGFNSVKMVNYDIKRDGTFKAYRQEGVKVKLGEGLGRGGYLSGEPVQRTIEALKLFRDIINFDSIRHVLPVATSAVRDAANRDSFLKQIREETGFQFKVLSGQEEGFYSYVGALASTCVPTSLFFDLGGGSLELVYTENYNVKKVESYPLGALRLSKTYSDNDSSFSKKAYGKMEERILDTLPDRKELGTSVDTTLVGVGGTLRAIARYEQELAGYELDKIHNYRMSYSSVSAIASELSKTDRGDLDKIKAIGSNRVDTIVAGSAVISLLMQKLDFDKVIVSARGLREGILSVFLRDPKAFYNNNNNSMTAERAKVYVTFACQQQGLLPQYAFSLVKPLVSAGLLREKERAILGHALKQIVVLPTVTNLSNLFHLIMDEDNAFLTHREQLILALAIVHTKKEKTVDWLFSRYGSILEPQNKKSIEKISACIALSEILERTKAMARLSISGNNNKKVAIKILQGKQQAAVPATLLASALRNFERAFDVTASCQIVVASTNGSAATKRQEVVRVIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRY1</accession>
    <name>A0A075MRY1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11 12">Homoserine kinase</fullName>
            <shortName evidence="11">HK</shortName>
            <shortName evidence="11">HSK</shortName>
            <ecNumber evidence="3 11 12">2.7.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">thrB</name>
        <name evidence="16" type="ORF">NTE_02212</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-homoserine + ATP = O-phospho-L-homoserine + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.39"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the GHMP kinase family. Homoserine kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.39" evidence="3 11 12"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRY1"/>
    <dbReference type="STRING" id="1459636.NTE_02212"/>
    <dbReference type="KEGG" id="nev:NTE_02212"/>
    <dbReference type="eggNOG" id="arCOG01027">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041243_1_1_2"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00064"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004413">
        <property type="term" value="F:homoserine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00384">
        <property type="entry name" value="Homoser_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000870">
        <property type="entry name" value="Homoserine_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002288">
        <property type="entry name" value="PRK01212.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00191">
        <property type="entry name" value="thrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20861:SF1">
        <property type="entry name" value="HOMOSERINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20861">
        <property type="entry name" value="HOMOSERINE/4-DIPHOSPHOCYTIDYL-2-C-METHYL-D-ERYTHRITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000676">
        <property type="entry name" value="Homoser_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00958">
        <property type="entry name" value="HOMSERKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0791">Threonine biosynthesis</keyword>
    <keyword evidence="6 11 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="14">
        <location>
            <begin position="76"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="15">
        <location>
            <begin position="224"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="NCBIfam" id="TIGR00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AIF84266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="322" mass="33441" checksum="88ABB54672CF6857" modified="2014-10-29" version="1">MDSMAVKKKPSSSCTAVAPSSTANLGPGYDVFGLALDARYDRVTITKRAGKDSNITIKMSDGAIPSVPESNSAGLVIKKMAQDFSITDDLDIVVKKGVPAGYGMGSSAASAAAAAVAFDGLYKLKLDKNRLVEYAAEGEVASAGTRHYDNVSASVLGGFIISSVGQDGIRFIRIEPPKDLFMVVAVPAIPVPAKKTEVARSVLPREVPLKSAVHNVSGASTLVAGFALGDVEMIARGIDNDVIVEPARKHLIPGYDSVRKNAFAAGALAVTISGAGPSVIAFLKGKTKRKQVIKAMEAGFMEVGIKCQTFACGPSKGARIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRY2</accession>
    <name>A0A075MRY2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01868</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRY2"/>
    <dbReference type="STRING" id="1459636.NTE_01868"/>
    <dbReference type="KEGG" id="nev:NTE_01868"/>
    <dbReference type="eggNOG" id="arCOG04796">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017896_3_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004377">
        <property type="term" value="F:GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038013">
        <property type="entry name" value="ALG11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45919">
        <property type="entry name" value="GDP-MAN:MAN(3)GLCNAC(2)-PP-DOL ALPHA-1,2-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45919:SF1">
        <property type="entry name" value="GDP-MAN:MAN(3)GLCNAC(2)-PP-DOL ALPHA-1,2-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="1">
        <location>
            <begin position="227"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="427" mass="47663" checksum="52201D719425FC3D" modified="2014-10-29" version="1">MNPCGGAEQVAIATIQALTEMDLEVELTVARCPDISRLRNAFGARKVDVIFSRIKRINLLDTLLTIQSKNCHDGNDCGINDTITINTHGDVLPYYLPCFSKVNAITYCHYPIVPGLALRRDPSYLDYLRSLGMIKFSYPTSKVDTGGNGKITDNRYTENDYSLFWQDLQKTYLMMLKHSTIITNSTFSKDAIQRELSPMPPVSSSTVQVVSEPIVIPPPVSVEEFRRATLYSKEREDFVVVISRFNPSKKLENAITLANMLKKQRIGKGMIIAGGLMPEDSDYYHHIVNLAKEYDVSDYVKFKVNVTSDNLKTILRKGKVYFHPMPGEPFGISVAEAMSCGLIPIVPSVGGHNDFVPKRYRYVSLEDAVGKISFALSASQEDRTSISNLVTRFSEANYVKSIQRLVANVLQGIRASDNVAYAEDTIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRY9</accession>
    <name>A0A075MRY9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01519</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700327.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRY9"/>
    <dbReference type="STRING" id="1459636.NTE_01519"/>
    <dbReference type="GeneID" id="41597306"/>
    <dbReference type="KEGG" id="nev:NTE_01519"/>
    <dbReference type="HOGENOM" id="CLU_1891501_0_0_2"/>
    <dbReference type="OrthoDB" id="9411at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="136" mass="15527" checksum="FAC68B223D279C3D" modified="2014-10-29" version="1">MAQEQDDEIEKMLRELHASYLKANEYDEGDPIFYRINYRLADAFSLTREEAENYHAEYHKKNPRRVSEGFCDACNRIVGIIPIIYGVQEGDMERMKAAEAQGRLIIGDITQVREGAKVAMFGCKVCKTPLAKYGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MS13</accession>
    <name>A0A075MS13_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein L4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_01835</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700583.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MS13"/>
    <dbReference type="STRING" id="1459636.NTE_01835"/>
    <dbReference type="GeneID" id="41597599"/>
    <dbReference type="KEGG" id="nev:NTE_01835"/>
    <dbReference type="eggNOG" id="arCOG04071">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026535_0_0_2"/>
    <dbReference type="OrthoDB" id="10737at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_uL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_uL4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045240">
        <property type="entry name" value="Ribosomal_uL4_euk/arch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19431">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="Ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF83895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="269" mass="28843" checksum="F85DEF1B580FCCF2" modified="2014-10-29" version="1">MTKATVTGIDGKDAGSIELPIVFETPYRPEVIHKVYVNLASHTYQRQGRYPAAGENVSAESRNTGLGIARLARARGEGFPRAGQAAGVAGVRHGRVAHPPESWKHIYKKINHKEKQLGLCSAIAATARRDLVEGRGHKLAKDVKLPLVVSNDIESVAKAKDLINTLSALGIADDLARAGATHKVRSGTARRRGRSARIGTSALVVVGNDAKALAIKSIPGVEVKTAKEISVLDLAPGSKPIRLTIFSQNAIEQLKEVKAPMHKVMEMIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MS78</accession>
    <name>A0A075MS78_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase</fullName>
            <shortName evidence="5">ADH synthase</shortName>
            <shortName evidence="5">ADHS</shortName>
            <shortName evidence="5">ADTH synthase</shortName>
            <ecNumber evidence="5 6">2.2.1.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">aroA'</name>
        <name evidence="8" type="ORF">NTE_01960</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate + L-aspartate 4-semialdehyde = 2,3-dioxopropyl phosphate + 2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate</text>
            <dbReference type="Rhea" id="RHEA:25952"/>
            <dbReference type="ChEBI" id="CHEBI:58859"/>
            <dbReference type="ChEBI" id="CHEBI:58860"/>
            <dbReference type="ChEBI" id="CHEBI:58861"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="2.2.1.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodecamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DeoC/FbaB aldolase family. ADHS subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.10" evidence="5 6"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700675.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MS78"/>
    <dbReference type="STRING" id="1459636.NTE_01960"/>
    <dbReference type="GeneID" id="41597708"/>
    <dbReference type="KEGG" id="nev:NTE_01960"/>
    <dbReference type="eggNOG" id="arCOG04044">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057069_2_0_2"/>
    <dbReference type="OrthoDB" id="6329at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016744">
        <property type="term" value="F:transketolase or transaldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00958">
        <property type="entry name" value="DhnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00960">
        <property type="entry name" value="ADH_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010210">
        <property type="entry name" value="ADH_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050456">
        <property type="entry name" value="DeoC/FbaB_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041720">
        <property type="entry name" value="FbaB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01949">
        <property type="entry name" value="ADH_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005556">
        <property type="entry name" value="PRK07226.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47916:SF1">
        <property type="entry name" value="3-HYDROXY-5-PHOSPHONOOXYPENTANE-2,4-DIONE THIOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47916">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATE ALDOLASE CLASS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038992">
        <property type="entry name" value="Aldolase_Ia"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 5" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0704">Schiff base</keyword>
    <keyword evidence="2 5 8" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="24"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5 7">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with dihydroxyacetone-P" evidence="7">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="5">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="24"/>
            <end position="28"/>
        </location>
        <ligand>
            <name>1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58861"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="142"/>
            <end position="144"/>
        </location>
        <ligand>
            <name>1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58861"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="198"/>
            <end position="199"/>
        </location>
        <ligand>
            <name>1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58861"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="226"/>
            <end position="227"/>
        </location>
        <ligand>
            <name>1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58861"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="NCBIfam" id="TIGR01949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR038992-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF84018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="260" mass="27727" checksum="E7F58314DCEC8A83" modified="2014-10-29" version="1">MVFGRDVRLSRILKDGKMLCIPMDHGISNGPIRGLEDAHGMIYQCEDAGLTCVLVNKGIVKTMPRPTSIGLIVHFSGSTSLGPAPNRKMLMGSVEEALRLGADAVSLHINIGAKEEPEMLQKLGMIADKCDEWSVPLVAMMYPRGEGIKNPHDPEIVAHAARVGAEAGADIVKAVYTGDIDSFRKVVKSVPVPLVIAGGPKATTDLEILEMCAGAMKAGAKGVTFGRNIFQHKNPPAMVRALHKVIFEGKSAKEAAKQLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSC8</accession>
    <name>A0A075MSC8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_02431</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701048.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSC8"/>
    <dbReference type="STRING" id="1459636.NTE_02431"/>
    <dbReference type="GeneID" id="41598139"/>
    <dbReference type="KEGG" id="nev:NTE_02431"/>
    <dbReference type="eggNOG" id="arCOG00371">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_626433_0_0_2"/>
    <dbReference type="OrthoDB" id="12017at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="161"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="383"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF84481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="437" mass="48249" checksum="47A9F7D1A903304B" modified="2014-10-29" version="1">MPFGLFKKKEAEKSEPAQIAPDTPQAGTMLSIQDVQSLLDSIESARVQSLSARLAPARESAMRSLASLASIADGMEKEKLKLEELEKRFGSNIENTKKMVVSALRREASSELPQVQTLGDAKKFKERMESMIHRFGEVTGSHSKMLNYFLKKHASGMKGELGDLEDLLKDVKAAISAFEQERAPVTRCSNMLNTILQKTSSARAEEQAAQATQERISALESDLAKLKEELATLEGSAEFAQAKATAEKLAQAEKRQEQFNAQVAEMFSHVSKALSKYSYGVSKETERRLRVLSEEPWTALGGEQQQGDTSSYSALLAEVYKSVASGQMQLKDSDKALQYLASIQSSLPQLQKESASISAEIAALHQERIHGVVLHGRRVEAMMAEHEDGLIRERQRLDQLRKQAAETNAGVDALLKEVSETLFSLTGKRYVVSRQQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSD9</accession>
    <name>A0A075MSD9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00177</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSD9"/>
    <dbReference type="KEGG" id="nev:NTE_00177"/>
    <dbReference type="HOGENOM" id="CLU_1197598_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="231" mass="24354" checksum="EC8D94A229DAADFB" modified="2014-10-29" version="1">MSRACNTEQTKSFLASITLLAAIVFVLIGPAPIAAVAQGENSSDRANVPLSSSSSGLQFSSQPIWEENATSTGVSIINQTHTRVDFIGNGTMTVLDTGETINMTNTGYGIITGRETVFAYGREHIHSEEDGDTTAITFYEIIRYDPATLQGKGIVIAAFDSNATGTLAPFNGMTVAGVHEENPDSKVATITLWKWESGIIGSNNNTATATTIASVAAAPSSPIMHEELPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSE0</accession>
    <name>A0A075MSE0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02021</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226986936.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSE0"/>
    <dbReference type="STRING" id="1459636.NTE_02021"/>
    <dbReference type="GeneID" id="41597765"/>
    <dbReference type="KEGG" id="nev:NTE_02021"/>
    <dbReference type="eggNOG" id="arCOG00910">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065731_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="283" mass="31160" checksum="41D208B134435B7F" modified="2014-10-29" version="1">MMANNDALAESIVRLKADFALNFKGTSPIHEAIPLDTSEFLPIEKSALAALHDFAKNNPIYYKWHDSKFFGVPCRVYEGDINEYWLGSIKHDSGYQPFYPTWILSAYALALASKRLGFGQVVDIGSGDGRIAYCARVAGLQAHGIEIDDNLVMLQEQIASATGVDFCARGADATKFDYHSLGLVRPVFFISGLPEMGEMLANSAIARILAVPELKHAAGFAFMGSHSLRKYARDLSKWGWGKVISDYGLQVAEVVTLPTHWTAEQAHDTPYVFTFTTTARTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSF6</accession>
    <name>A0A075MSF6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00197</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSF6"/>
    <dbReference type="KEGG" id="nev:NTE_00197"/>
    <dbReference type="HOGENOM" id="CLU_2856915_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="64" mass="7008" checksum="8056E892D43017AC" modified="2014-10-29" version="1">MFLVLGFAVASLVMIMPTTAFASSSYDNSEDDKNKCDDSSDDYKCVLRGSLITSNNQCKKEMNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSK1</accession>
    <name>A0A075MSK1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Galactose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="8">2.7.7.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NTE_02048</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.12" evidence="8"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700743.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSK1"/>
    <dbReference type="STRING" id="1459636.NTE_02048"/>
    <dbReference type="GeneID" id="41597787"/>
    <dbReference type="KEGG" id="nev:NTE_02048"/>
    <dbReference type="eggNOG" id="arCOG00422">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029960_1_0_2"/>
    <dbReference type="OrthoDB" id="7650at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008108">
        <property type="term" value="F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053177">
        <property type="entry name" value="ADP-glucose_phosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001937">
        <property type="entry name" value="GalP_UDPtransf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005849">
        <property type="entry name" value="GalP_Utransf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42763">
        <property type="entry name" value="ADP-GLUCOSE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42763:SF2">
        <property type="entry name" value="ADP-GLUCOSE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01087">
        <property type="entry name" value="GalP_UDP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000808">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Galactose-1-phosphate uridyl transferase N-terminal" evidence="7">
        <location>
            <begin position="102"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="20"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-UMP-histidine intermediate" evidence="4">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF84105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="353" mass="39217" checksum="4CCDF930911B235C" modified="2014-10-29" version="1">MRELRKDYVLDRFVLVPNNTSSSTSAAERGGDEKRDGVDDDDKCPYCPGNESMTSPALLALVVKDGMLQRLSDSEDSIIDDWSVRVFESKNPVVTTTAAASYSDKPLYSEPAYGYHQVVVATPDHKQSLPQMSVEQWGNVLVVIQDRVRWLYTQKSVTYVSIYVNSGAGAGAQSPHPHLNIVTFSSIPPAIELEAEGSHRFMNENGSCPACNMISVESSGPRQVLATDSFLAFCPWAPTYPYEFWIYPKRHITSFSKITQKEINDLALMMRATLGGMSKALKDAPFNMVFHLSPEKKNSRQIHWHIEVYPQLTTWSGLERGFGVYVNNVKPEKAAEILGSACRKELAGLVGIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSX2</accession>
    <name>A0A075MSX2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zn-dependent oxidoreductase, NADPH:quinone reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_02221</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700881.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSX2"/>
    <dbReference type="STRING" id="1459636.NTE_02221"/>
    <dbReference type="GeneID" id="41597942"/>
    <dbReference type="KEGG" id="nev:NTE_02221"/>
    <dbReference type="eggNOG" id="arCOG01458">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_3_4_2"/>
    <dbReference type="OrthoDB" id="8709at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051603">
        <property type="entry name" value="Zinc-ADH_QOR/CCCR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44154">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44154:SF1">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="12"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF84275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="349" mass="38287" checksum="75DD5EF3D22D5D43" modified="2014-10-29" version="1">MKAAVYRSHGKDPRQVVRIEDIDVPKLKSNEVLIKVEASAYNYNDLWGIWGEPIKIPLPHISGSDVAGTVVEVGDEVSKIKKGDRVVSHPNLTCRVCYECTSGREYDCKDRLVWGFQTGPLWGGFAQYTHLPEVNAVKLPDNVSFNDAAAISMVGMTAWHMLVTRAGIRPGQTVLIMGGGSGMGIAGIQIAKLFNCEVIATAGNKEKMDKCIELGADYVVNHREDGWHRKVRDITNKLGVDVVYEHIGKTVFPQEIGLLKMGGTLVSTGATTGYDSTIDLRYLFFRGINILGATQGTRAGLEEVIKWVSKGKIKAVIDTILPFSNMIEGHVKMADSQLFGKILTTPQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MT30</accession>
    <name>A0A075MT30_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc-ribbon domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MT30"/>
    <dbReference type="STRING" id="1459636.NTE_00397"/>
    <dbReference type="KEGG" id="nev:NTE_00397"/>
    <dbReference type="eggNOG" id="arCOG01917">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG05362">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_992538_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026870">
        <property type="entry name" value="Zinc_ribbon_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13240">
        <property type="entry name" value="Zn_Ribbon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zinc-ribbon" evidence="1">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="323" mass="35550" checksum="C0AA4AEE84D7D3D5" modified="2014-10-29" version="1">MEEPFRLKYYFLRADRMGKTEKFSGLNTDLERLANRVEMYLQENGFEVAFSKDPTAPASWFFIQARKASALRTVAGARRSTDITIKGSPGSFEVSVGTGEWGKNLVTSAPLFIVPVVGISATLVKLYTAKKFEDNLWKYIRDQSRFLADSALSTATEKSSSSSSAASGVGIDSRAYECDYVEGYPGWNEQILGGKLLLVREKGGGKNRLAFKSPDSKEIMIPSANVIEAHIIARKKGLNEDDLMIQLTCKDASDGRTVRPVFNLNDDIIRGVLAGINELVGEDKVLRSFEQVNVTTETKYCTSCGVQIPKEAKFCSSCGTKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MT77</accession>
    <name>A0A075MT77_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative flavoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_02269</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SsuE family. Isf subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MT77"/>
    <dbReference type="STRING" id="1459636.NTE_02269"/>
    <dbReference type="KEGG" id="nev:NTE_02269"/>
    <dbReference type="eggNOG" id="arCOG04624">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055322_1_2_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050712">
        <property type="entry name" value="NAD(P)H-dep_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30543">
        <property type="entry name" value="CHROMATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30543:SF21">
        <property type="entry name" value="NAD(P)H-DEPENDENT FMN REDUCTASE LOT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADPH-dependent FMN reductase-like" evidence="2">
        <location>
            <begin position="14"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF84323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="204" mass="22529" checksum="DED82C36ED9E452F" modified="2014-10-29" version="1">MCMDTERNMQSAVNILCVAGSIREGSYSTKALKMALEFAKKRGAEVRILDLSKTVLPLRDPGAPASEQVEEAAKAVAWADAFMLASPDYHGSISGALKNFLDHFYEEFAGKVFGYIVASHEKGLTVMDQMRTAVRQCYGWSLPYGVSVNGEQDFANGQISNAELSKRLEMMSRDLVVYGRLIKRQFACDLGSSDPDTFAARYRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MT93</accession>
    <name>A0A075MT93_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA primase large subunit PriL</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">priL</name>
        <name evidence="9" type="ORF">NTE_01964</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="7">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterodimer of a small subunit (PriS) and a large subunit (PriL).</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the eukaryotic-type primase large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MT93"/>
    <dbReference type="STRING" id="1459636.NTE_01964"/>
    <dbReference type="KEGG" id="nev:NTE_01964"/>
    <dbReference type="eggNOG" id="arCOG03013">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052778_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06560">
        <property type="entry name" value="PriL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00701">
        <property type="entry name" value="DNA_primase_lrg_arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058560">
        <property type="entry name" value="DNA_primase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007238">
        <property type="entry name" value="DNA_primase_lsu_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023642">
        <property type="entry name" value="DNA_primase_lsu_PriL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10537">
        <property type="entry name" value="DNA PRIMASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10537:SF3">
        <property type="entry name" value="DNA PRIMASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04104">
        <property type="entry name" value="DNA_primase_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140914">
        <property type="entry name" value="PriB N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2 7" id="KW-0639">Primosome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA primase large subunit C-terminal" evidence="8">
        <location>
            <begin position="239"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF84022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="347" mass="39996" checksum="097A11B0BA1EF886" modified="2014-10-29" version="1">MQFRKQLAVKKLSIKMGTGDLAKYPFLNEAGEYLRQSGFGWDELDRPDTKDIIERAAERVRIAAAGNVYEKLDRYETEILTFIVTLIMVKSIGLEPVLRKYALAEARRAEKFLTDDLKKQSDAQKRALFSKIFEDLFGLKIDVTEDGRLFKVKVTDYLMRSSHFHEQEWKMINRLVQGGQVFLDADETVRLVRNELSVLITSRVRAMNLPTLPQSIKQKVEELRTELAPRYEYRTYAVTDYPPCVKHALEVMARGENLPHSARLMLATYMLAIGKPIDEIVEMFKNAPDFNERITRYQVEHLAGSKGSRTKYSVPSCEKLRTENLCFATAECNGIINPVQFGRKKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MT98</accession>
    <name>A0A075MT98_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pirin-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_02739</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the pirin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MT98"/>
    <dbReference type="KEGG" id="nev:NTE_02739"/>
    <dbReference type="eggNOG" id="arCOG02935">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045717_5_1_2"/>
    <dbReference type="OrthoDB" id="23530at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd02247">
        <property type="entry name" value="cupin_pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02909">
        <property type="entry name" value="cupin_pirin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008778">
        <property type="entry name" value="Pirin_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903:SF31">
        <property type="entry name" value="CUPIN-DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903">
        <property type="entry name" value="PIRIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02678">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05726">
        <property type="entry name" value="Pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006232">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pirin N-terminal" evidence="3">
        <location>
            <begin position="26"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Pirin C-terminal" evidence="4">
        <location>
            <begin position="182"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF84781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="295" mass="32432" checksum="6DD62D147AB836DF" modified="2014-10-29" version="1">MADMTIRTVKKIVNSVATMEGEGFLVHRSFPTNALMQFDPFLLLDEMGPKEYGPGEAKGAPDHPHRGFETVTYMLEGKFQHKDSNGNSGRLGPGDVQWMTAGAGVVHSEMPEEEFADAGGRLHGFQLWVNLPKRDKMAKPRYQDISASKIPVASTEGTSVRVIAGEALGKKAVIDTHTPIVYLHYTLKPGARVEQEVPRDYNVFAYVVEGEGEFGEKEKKKKAKRGQMAIFERDGDSVSIAAPKDAASDLSVLLIGGVPLGEPVARYGPFVMNTQDEIYQTIEDYREGRFGRIGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTF2</accession>
    <name>A0A075MTF2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein-disulfide isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NTE_02430</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutaredoxin family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family. DsbA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701047.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTF2"/>
    <dbReference type="STRING" id="1459636.NTE_02430"/>
    <dbReference type="GeneID" id="41598138"/>
    <dbReference type="KEGG" id="nev:NTE_02430"/>
    <dbReference type="eggNOG" id="arCOG02868">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_47_1_2"/>
    <dbReference type="OrthoDB" id="15256at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13887:SF14">
        <property type="entry name" value="DISULFIDE BOND FORMATION PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13887">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13462">
        <property type="entry name" value="Thioredoxin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Thioredoxin" evidence="7">
        <location>
            <begin position="48"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF84480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="236" mass="25522" checksum="8ACEFA4BCB36A3BF" modified="2014-10-29" version="1">MGKKSNKNILIAVIAAGIIVAAGAGVAFSNTFAQKPQQQTDEEFARMVFQKMQSPTIAAAPVLGNASAPVTVVEFGDYLCTFCHRFHEDTKDKLMADYVETGKARFVFKDFPINDHLGGGSSLGAQASYCAADQGKFWEFHDFMYNNWGGERAGWITKENMADFAQKVGVSNVDQFKSCLDSGKYASAVKDNYNMAKSVGLGATPSFVIIPAAGEPKLVVGAQPYQVFQQVIDESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTF5</accession>
    <name>A0A075MTF5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02341</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700974.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTF5"/>
    <dbReference type="STRING" id="1459636.NTE_02341"/>
    <dbReference type="GeneID" id="41598057"/>
    <dbReference type="KEGG" id="nev:NTE_02341"/>
    <dbReference type="HOGENOM" id="CLU_3003276_0_0_2"/>
    <dbReference type="OrthoDB" id="375982at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="64" mass="7300" checksum="1FEDB3747519E896" modified="2014-10-29" version="1">MMKENGNSGNSSGEREMMYQEFRQLGIPVDEFYLLSNSALKHLLDSIREAIVEYRNSARLSSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTF6</accession>
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        <recommendedName>
            <fullName evidence="2">UPF0147 protein NTE_02015</fullName>
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    </protein>
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        <name evidence="4" type="ORF">NTE_02015</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
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        <lineage>
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            <taxon>Nitrososphaeria</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0147 family.</text>
    </comment>
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    <dbReference type="HOGENOM" id="CLU_165882_0_1_2"/>
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    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.50">
        <property type="entry name" value="Ta0600-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00342">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ta0600-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005354">
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    <dbReference type="Pfam" id="PF03685">
        <property type="entry name" value="UPF0147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158436">
        <property type="entry name" value="Ta0600-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF84072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="100" mass="11169" checksum="2965CE96913F0587" modified="2014-10-29" version="1">MTSSSSSSKKGQKEKENQERLARAVETLDTITKNNDVQKSIRNMIKEVLMALKDEKSGSMSVRAANAISLLDSATQSPQMQSHIRTMLWQVVSTLESIRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTH1</accession>
    <name>A0A075MTH1_9ARCH</name>
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        <recommendedName>
            <fullName evidence="1">AttH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02025</name>
    </gene>
    <organism evidence="2 3">
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        <lineage>
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            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="KEGG" id="nev:NTE_02025"/>
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    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="entry name" value="AttH-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR010791">
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    </dbReference>
    <dbReference type="Pfam" id="PF07143">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159245">
        <property type="entry name" value="AttH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AttH" evidence="1">
        <location>
            <begin position="8"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="239" mass="26418" checksum="6E29AF4AF6272927" modified="2014-10-29" version="1">MGENWVRGNLTNYQLHVQSAKGYGADLTFTREAPSSRFGGTGKEYWDPSLTQYSAWFVAMPSAKVKGTLTYDGEAHPVQGSGYHDHNWGTVEYNKVMDHWYWSRANFGNYTLDLALRVASSFYDYQQLPAFTLAKGNQVLAEGMKFVTVQGTGNNTSPLGHDYPSQLTFNYQNGSDTVRLTLSDPHLIVAGSSTVVTNATALGHPEYLRFKGTGELSVNIAGSSETLRGPIIWEINYGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTT8</accession>
    <name>A0A075MTT8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative cobalt transporter subunit (CbtB)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02509</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="GeneID" id="41598213"/>
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_168228_1_1_2"/>
    <dbReference type="OrthoDB" id="8286at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012667">
        <property type="entry name" value="CbtB_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09489">
        <property type="entry name" value="CbtB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="77" mass="8270" checksum="30D05B099F1B917E" modified="2014-10-29" version="1">MSFTNQIARATEGVPKIAVGILLGILVFGIFVVGFDQGQLFALAQGNPADPANPAYENLLMHEFTHDMRHAAGFACH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MU21</accession>
    <name>A0A075MU21_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sec-independent protein secretion pathway component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NTE_02632</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
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            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701205.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MU21"/>
    <dbReference type="STRING" id="1459636.NTE_02632"/>
    <dbReference type="GeneID" id="41598325"/>
    <dbReference type="KEGG" id="nev:NTE_02632"/>
    <dbReference type="eggNOG" id="arCOG02694">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086034_3_2_2"/>
    <dbReference type="OrthoDB" id="10785at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.3310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003369">
        <property type="entry name" value="TatA/B/E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42982">
        <property type="entry name" value="SEC-INDEPENDENT PROTEIN TRANSLOCASE PROTEIN TATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42982:SF1">
        <property type="entry name" value="SEC-INDEPENDENT PROTEIN TRANSLOCASE PROTEIN TATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02416">
        <property type="entry name" value="TatA_B_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF84675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="116" mass="12800" checksum="751B84CEB170A220" modified="2014-10-29" version="1">MPFSGLLLDIAGSEWAIIILVALILIFGTKRLPQVSRSLGKAVGEYEKARQQFRQEMQDATEQARREAGISKVPRITSPVATEREKLEVIATSLGIDCAGKSDEELRSLISQRMNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MU51</accession>
    <name>A0A075MU51_9ARCH</name>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00756</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
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        <lineage>
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            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AIF82834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385051.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MU51"/>
    <dbReference type="STRING" id="1459636.NTE_00756"/>
    <dbReference type="GeneID" id="43502577"/>
    <dbReference type="KEGG" id="nev:NTE_00756"/>
    <dbReference type="HOGENOM" id="CLU_3130666_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="49" mass="5522" checksum="65A62A826A3445E1" modified="2014-10-29" version="1">MMTKRNYVEEMCVYGHFAGAVTALQNNIVIIITTCAVSKNEERCKKESP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MU52</accession>
    <name>A0A075MU52_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF488 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00761</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699732.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MU52"/>
    <dbReference type="STRING" id="1459636.NTE_00761"/>
    <dbReference type="GeneID" id="41596612"/>
    <dbReference type="KEGG" id="nev:NTE_00761"/>
    <dbReference type="eggNOG" id="arCOG06027">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_137928_0_0_2"/>
    <dbReference type="OrthoDB" id="7940at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052552">
        <property type="entry name" value="YeaO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36849:SF1">
        <property type="entry name" value="CYTOPLASMIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36849">
        <property type="entry name" value="CYTOPLASMIC PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22752">
        <property type="entry name" value="DUF488-N3i"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="113" mass="13516" checksum="5C38E089F451C534" modified="2014-10-29" version="1">MIRVARIYSFENDKSYRVLVDRLWPRGVNKSSVDLWLRDIAPSDALRRWFSHDPKKWDGFKERYFKELDERQELVKAILEKEKQGLVTLLFAAKDAEHNNAVALLEYLKRFNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MU64</accession>
    <name>A0A075MU64_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Bacterioferritin (Cytochrome b1)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NTE_02203</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700864.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MU64"/>
    <dbReference type="STRING" id="1459636.NTE_02203"/>
    <dbReference type="GeneID" id="41597924"/>
    <dbReference type="KEGG" id="nev:NTE_02203"/>
    <dbReference type="eggNOG" id="arCOG01093">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122243_0_0_2"/>
    <dbReference type="OrthoDB" id="359318at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00657">
        <property type="entry name" value="Ferritin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002024">
        <property type="entry name" value="Bacterioferritin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30295">
        <property type="entry name" value="BACTERIOFERRITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30295:SF0">
        <property type="entry name" value="BACTERIOFERRITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00601">
        <property type="entry name" value="BACFERRITIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0409">Iron storage</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin-like diiron" evidence="7">
        <location>
            <begin position="52"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="134"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF84257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="191" mass="21219" checksum="4BDEA419F7DE2A55" modified="2014-10-29" version="1">MVAIEKSASSKKKCKSSDHLRNSLFQDIRIGKTLSKSKNSQPASADAEGVSPPSRSEIIAGLNEDLAREYKSIIQYAVFSSTLKGPEYGDIAEQLKKHASQELAHALEVARQIDYLGGDPTVKSKDAEFSDDSKKMLEIDLRAEQETIKNYRERIIQAERGGEFALSEKLRGIIAQEQDHEIDLKDALGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MU82</accession>
    <name>A0A075MU82_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">NTE_02672</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MU82"/>
    <dbReference type="STRING" id="1459636.NTE_02672"/>
    <dbReference type="KEGG" id="nev:NTE_02672"/>
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    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="186" mass="19385" checksum="AB1362ACA8C7028E" modified="2014-10-29" version="1">MTSTGTLRQKPLGKSVACGAVGGIIAGLVMAPFMMLTGIAVGMPADTMLKAIGLMFGASMDNAVMAGFGIHMLTSILIGAIFGFVTSAVKKLNITSMGKGIGEGVITGAIALAVLFLPVSMVMMPLVLMRMMLSMNPGATQQVMSMMQQAMPTMMGIGVIEHLVYGAVLGTVTSVFVLREARNRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUC7</accession>
    <name>A0A075MUC7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03222</name>
    </gene>
    <organism evidence="2 3">
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        <lineage>
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            <taxon>Nitrososphaerota</taxon>
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            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701684.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUC7"/>
    <dbReference type="STRING" id="1459636.NTE_03222"/>
    <dbReference type="GeneID" id="41598878"/>
    <dbReference type="KEGG" id="nev:NTE_03222"/>
    <dbReference type="HOGENOM" id="CLU_2475838_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="87" mass="10148" checksum="0232FBE6471C729F" modified="2014-10-29" version="1">MAAVVVVKEKTFKCKECGTELPSKEHLRKHQRFHKERAWKEAGYADPNNVDYPTFLNPTNSRAAFFISHLLGTDEESKKKRKKSRQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUC9</accession>
    <name>A0A075MUC9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dinuclear metal center protein, YbgI/SA1388 family</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_02754</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP cyclohydrolase I type 2/NIF3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701308.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUC9"/>
    <dbReference type="STRING" id="1459636.NTE_02754"/>
    <dbReference type="GeneID" id="41598443"/>
    <dbReference type="KEGG" id="nev:NTE_02754"/>
    <dbReference type="eggNOG" id="arCOG04454">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075763_0_0_2"/>
    <dbReference type="OrthoDB" id="8041at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1390.30">
        <property type="entry name" value="NIF3 (NGG1p interacting factor 3)-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002678">
        <property type="entry name" value="DUF34/NIF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036069">
        <property type="entry name" value="DUF34/NIF3_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01784">
        <property type="entry name" value="DUF34_NIF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102705">
        <property type="entry name" value="NIF3 (NGG1p interacting factor 3)-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR602678-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF84795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="276" mass="30281" checksum="A26012338B02B928" modified="2014-10-29" version="1">MVTSGVDTEEIMKAGLELAGWKKMPADSMVHVRGKNIKKVMMAIDIGTAELLLAKSLGCDAVIAHHPIGIAAINFYKVFDKHTDYMVEHGVPKSVAKEATEKLKERVETKTHANIYDDVVGAARAMKMPLVNIHQPCDEYMRQAILAKIKSGKTEYVSDIVESVSRIPEFRHAETRVQVRHGSEKNRVGHWALVIAAGTNGGYSIAKAYFQHGVDTVIYLHVDYGDLVKMREEKLQGNLVVLGHLAGDSLGLNALAGKLEQEMGVETVRIGLLPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUD0</accession>
    <name>A0A075MUD0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00868</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUD0"/>
    <dbReference type="STRING" id="1459636.NTE_00868"/>
    <dbReference type="KEGG" id="nev:NTE_00868"/>
    <dbReference type="HOGENOM" id="CLU_200904_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="68" mass="7935" checksum="BB8C772B599C44AF" modified="2014-10-29" version="1">MLLLFDAICMICMKSEMCRYAHICKLYDDNSATCHSDEEASGYCGAYDDFDNYKPVFMPKLEKKLFTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUE8</accession>
    <name>A0A075MUE8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02691</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701251.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUE8"/>
    <dbReference type="STRING" id="1459636.NTE_02691"/>
    <dbReference type="GeneID" id="41598380"/>
    <dbReference type="KEGG" id="nev:NTE_02691"/>
    <dbReference type="eggNOG" id="arCOG08673">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101753_0_0_2"/>
    <dbReference type="OrthoDB" id="9841at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="171" mass="18233" checksum="1A5953F4FAA32666" modified="2014-10-29" version="1">MTKGSKPDARTQKSGIKIIIIAAIAVIAAGITAAAASGAIQPPNAPMASTNNDKPMVMHIHPKLSLLVGGQETQVPQNIGIDKTLWNDHSLDSFGMQGMAPLHTHDTSGTIHVESNEQRDYTLGQLLDIWGVMSDSKYAGKEVKVIADGSPVPDFKNLVLKDGQEIRLEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUG7</accession>
    <name>A0A075MUG7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00883</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUG7"/>
    <dbReference type="STRING" id="1459636.NTE_00883"/>
    <dbReference type="KEGG" id="nev:NTE_00883"/>
    <dbReference type="eggNOG" id="arCOG03633">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1187816_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="208" mass="21499" checksum="70B6D2DACFCB4898" modified="2014-10-29" version="1">MKRGHIVLISGVVLLVTGITISVVWGISFAGSFLKENTIVAKTTIEPGRSVDARANVNQLGKPLSLAIGIDKSGQQQQAFSDIRLKETITDPTGKVVSSHEFGESFFNSFNPQIAGIYTVTVSNLGTQPVSVSGAFGYMSFVGSDGKPNINAIAGEEGGLGMVIAGGGLAAAGIIALIVGAIITVIDSRAQRQGSTKASENGISYKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUJ0</accession>
    <name>A0A075MUJ0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00903</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUJ0"/>
    <dbReference type="KEGG" id="nev:NTE_00903"/>
    <dbReference type="eggNOG" id="arCOG10856">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117038_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.210.10">
        <property type="entry name" value="Cytochrome c oxidase-like, subunit I domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036927">
        <property type="entry name" value="Cyt_c_oxase-like_su1_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81442">
        <property type="entry name" value="Cytochrome c oxidase subunit I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="199" mass="21048" checksum="04ECF343048C55A7" modified="2014-10-29" version="1">MSRVGNEKDKWTKRFMAAAIVQGAIVAGLTIFLLLSQISFLKPEISRVIAGGGAGTWFTFGYVMYIIIGVIGVAVSALFYHYLENVVGKRMQKGADVLAWVHLILMNIGTVATMGMLMYAGYIGGASMLPQSVGGKGYNAGQAHEILAPFVEPISATVIMIVIGVIAGGAGFLLTYSSTSSGRESFSERRRGKGATEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUP8</accession>
    <name>A0A075MUP8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alanyl-tRNA synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02823</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701365.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUP8"/>
    <dbReference type="STRING" id="1459636.NTE_02823"/>
    <dbReference type="GeneID" id="41598508"/>
    <dbReference type="KEGG" id="nev:NTE_02823"/>
    <dbReference type="eggNOG" id="arCOG01255">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_893161_0_0_2"/>
    <dbReference type="OrthoDB" id="11392at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140101">
        <property type="term" value="F:catalytic activity, acting on a tRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006399">
        <property type="term" value="P:tRNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="330" mass="35647" checksum="1EBB05A57D600F7D" modified="2014-10-29" version="1">MEGEKATMVAAAHTAEHAFIGALQKILGRTLQVRKVEHNKKDGGNTAFIAISQLDIDTIVRAEVMVNALIEEGREVTTRTYPSLGEARNANPSLRANEQRISGEVRVVEIAGHDVTACAMEHVGNLQECGFFLVTRLSRSGSEYEVDFAVGRHAKDTAVSLSAKMIKVCGELGANLNTVENTARKVRLEGESAFKKLKALSMEKLRSMVPAENNNSKIRVYSGVFSGLADESLQEFAGEKIAEPNAVVVIANKNNNAAGAESDDNNNAYFIFARNEAMENIDLDCNKVFREAAGADGRGGGKPHFVTGVVKKEKAEEIIRKISGGVLQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUR2</accession>
    <name>A0A075MUR2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Archaeal flagella assembly protein J</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700992.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUR2"/>
    <dbReference type="STRING" id="1459636.NTE_02360"/>
    <dbReference type="GeneID" id="41598076"/>
    <dbReference type="KEGG" id="nev:NTE_02360"/>
    <dbReference type="eggNOG" id="arCOG01809">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036985_0_0_2"/>
    <dbReference type="OrthoDB" id="141855at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056569">
        <property type="entry name" value="ArlJ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35402:SF2">
        <property type="entry name" value="FLAGELLA ACCESSORY PROTEIN J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35402">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0282">Flagellum</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="429"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="458"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="500" mass="54363" checksum="F1844ACCF14C6851" modified="2014-10-29" version="1">MKAGLDLKKILPFLPGQSKSSSTLDETLVYFVTFLFSLATAEISPANLLKTAGSVGYGTYSKTVTEIYNLGLRWQYGIATAAGIVASQMPNEEFKLFLMKLEQVIRLGDSLRDFLKSEMAAVVNAYAAAYERSMESLKLLLGMFSTLMSTASFMIAAMMIMSMIGGGDSSTIIVVAFATISGLGAFAFMMYMIFPKDKLMNENGEHLRQFKKIFLPSVGASVAIGVALLFVPQVPREIIVSAVGGPLILPGFMARRVEGRIKKLDESFPSFIRHLTEIYSTVGSLGQALKTVMKSDFGGLSTHARSMLNRVLNRVTMEHAFDLFSIDTGNELITASNKVISISMVKGANMIEVGETLAQLTARFNDLRKKRQQVSKAFETTVLILHVLTVAVMSFMKGVFQFFADIFGHLDKSMGASVIQPIPPDTMNIVLPLMIVALACINGLVIKISQGGLYKTMWFNIGLLLVIGGVVSFGVQQFVGEMFGDIIGANPFGDLATQVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUS1</accession>
    <name>A0A075MUS1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative flavin-nucleotide-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_02370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385438.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUS1"/>
    <dbReference type="STRING" id="1459636.NTE_02370"/>
    <dbReference type="GeneID" id="41598085"/>
    <dbReference type="KEGG" id="nev:NTE_02370"/>
    <dbReference type="eggNOG" id="arCOG00516">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123922_5_1_2"/>
    <dbReference type="OrthoDB" id="139492at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070967">
        <property type="term" value="F:coenzyme F420 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052019">
        <property type="entry name" value="F420H2_bilvrd_red/Heme_oxyg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35176">
        <property type="entry name" value="HEME OXYGENASE HI_0854-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35176:SF6">
        <property type="entry name" value="HEME OXYGENASE HI_0854-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="PNPOx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine 5'-phosphate oxidase N-terminal" evidence="2">
        <location>
            <begin position="16"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF84422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="149" mass="16850" checksum="5D4DA9242F378952" modified="2014-10-29" version="1">MKFTLADAHARQLSRKQVAQLFARPNLLRLAFLDEKGRPMVHPVWYYYSRGKFYFATDRNGRKAGALRKNPDVYFLVDENPSGEPPLGVRGRGTAKVIDDSKYATRVTRRCVKRYLGTTKSKSAKMVIAMGPDSCVVEVTPSAMASWKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUU2</accession>
    <name>A0A075MUU2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alcohol dehydrogenase, class IV</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_00994</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699908.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUU2"/>
    <dbReference type="STRING" id="1459636.NTE_00994"/>
    <dbReference type="GeneID" id="41596822"/>
    <dbReference type="KEGG" id="nev:NTE_00994"/>
    <dbReference type="eggNOG" id="arCOG00984">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_884552_0_0_2"/>
    <dbReference type="OrthoDB" id="57329at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08551">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056798">
        <property type="entry name" value="ADH_Fe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496:SF83">
        <property type="entry name" value="HYDROXYACID-OXOACID TRANSHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25137">
        <property type="entry name" value="ADH_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA" evidence="2">
        <location>
            <begin position="7"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Fe-containing alcohol dehydrogenase-like C-terminal" evidence="3">
        <location>
            <begin position="159"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF83069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="316" mass="35052" checksum="9F4CCF86F2CD505B" modified="2014-10-29" version="1">MWKVMMPRKIAFGENAAKEFQYPKNSLVITTTTPDIYNKWLDYMGIKNYEVYDKVTPDPSIEAIEAIKKQYEGKEIGAYIGLGGGSSMDVCKYLSKLTGIPKILIPTTFGTGAEMTTYAVISFEHKKKLLQDEAFLADAAIVDPYFLPGTPFNILRNSACDAAAQASEGYDSKAGNPFTQFFCREAFDILYDAIMNDKHHMLPYGAMLSGIGFGNSSTTLGHALSYVFSNEGVPHGYALSSCTTVAHKFNKSPYYKRFKEIAQKFKFEPLKLKQPLDAAADVIMPDRGHLDNNPIPVTKQDVVKCLDEIVNTNPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUU8</accession>
    <name>A0A075MUU8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02944</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385569.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUU8"/>
    <dbReference type="STRING" id="1459636.NTE_02944"/>
    <dbReference type="GeneID" id="43502664"/>
    <dbReference type="KEGG" id="nev:NTE_02944"/>
    <dbReference type="HOGENOM" id="CLU_3148102_0_0_2"/>
    <dbReference type="OrthoDB" id="7464at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="48" mass="5735" checksum="3AB43B58DE7EE0D8" modified="2014-10-29" version="1">MFGKAKCKLCGDEVRFALRHLHEKHPEVIKGEQMNRDKMQKLVEKYFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MV31</accession>
    <name>A0A075MV31_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03066</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385601.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MV31"/>
    <dbReference type="STRING" id="1459636.NTE_03066"/>
    <dbReference type="GeneID" id="43502669"/>
    <dbReference type="KEGG" id="nev:NTE_03066"/>
    <dbReference type="HOGENOM" id="CLU_3002962_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="56" mass="6122" checksum="74B7DB2EBFA756B4" modified="2014-10-29" version="1">MHKDSEIEIVGSNFSVGQVLAIVKAHNGGVSMVQIRRRFKVSPKALRIMLTEAGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MV48</accession>
    <name>A0A075MV48_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative flavoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_03091</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SsuE family. Isf subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701576.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MV48"/>
    <dbReference type="STRING" id="1459636.NTE_03091"/>
    <dbReference type="GeneID" id="41598752"/>
    <dbReference type="KEGG" id="nev:NTE_03091"/>
    <dbReference type="eggNOG" id="arCOG04624">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055322_4_2_2"/>
    <dbReference type="OrthoDB" id="9059at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050712">
        <property type="entry name" value="NAD(P)H-dep_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30543">
        <property type="entry name" value="CHROMATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30543:SF21">
        <property type="entry name" value="NAD(P)H-DEPENDENT FMN REDUCTASE LOT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADPH-dependent FMN reductase-like" evidence="2">
        <location>
            <begin position="11"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF85125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="199" mass="22082" checksum="8517D0FF3BE62270" modified="2014-10-29" version="1">MNNDNYNNNSVKILGIAGSLRRGSYNRAALRAAQKLLPGNARLEIFELDGIPPFNQDIEMQPPQAVSELKSKVRSADAVLFVTPEYNYSVSGVLKNAIDWGSRPHGDSAWEGKPAAIMGASVGMLGTARAQYHLRQMFVFLNMYALNRPEVMIANAARKFDAQGNLVDDETRERIRELMSALVSWTARLRQMQNKLAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MV80</accession>
    <name>A0A075MV80_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NTE_03528</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MV80"/>
    <dbReference type="STRING" id="1459636.NTE_03528"/>
    <dbReference type="KEGG" id="nev:NTE_03528"/>
    <dbReference type="HOGENOM" id="CLU_1718130_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052053">
        <property type="entry name" value="IM_YidH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34187:SF2">
        <property type="entry name" value="DUF202 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34187">
        <property type="entry name" value="FGR18P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="8">
        <location>
            <begin position="46"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF85556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="152" mass="16375" checksum="7926967396E99D20" modified="2014-10-29" version="1">MEKNGDAFTLYSLQSDSVTDDNEEIRVSGKGSGNNKEHDVDSSTQFLANERTFLALLRTCIAVIGLGFVVARFSLFLREFGLITMTRREGGAIQQDLSLSLSSSSSAAHSPSSLLGPGMVGLGIALAGYAFYNYKKAHRIIESGEAMCRSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVC2</accession>
    <name>A0A075MVC2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVC2"/>
    <dbReference type="KEGG" id="nev:NTE_03079"/>
    <dbReference type="HOGENOM" id="CLU_1607075_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="114"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="165" mass="17043" checksum="7BFDA50328E1F2C8" modified="2014-10-29" version="1">MSPMSKIRENKVTLLSLWIVGVAIASFAVVPSMAFAGGYGESEGEDNNSSGSGGAESTNNDSGGDNVDTQTFEHVKTKTTTTDVHKQITKKEIVGTKTTLTTKVTEDESGDTGEGAIAAAEANGSSISGDCECTTTTGGDSNDSEDSEGEDDEGEYSNSNDKSSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVI9</accession>
    <name>A0A075MVI9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Holliday junction resolvase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02634</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).</text>
            <dbReference type="EC" id="3.1.21.10"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701206.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVI9"/>
    <dbReference type="STRING" id="1459636.NTE_02634"/>
    <dbReference type="GeneID" id="41598327"/>
    <dbReference type="KEGG" id="nev:NTE_02634"/>
    <dbReference type="eggNOG" id="arCOG00919">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1478852_0_0_2"/>
    <dbReference type="OrthoDB" id="10109at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002732">
        <property type="entry name" value="Hjc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01870">
        <property type="entry name" value="Hjc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="176" mass="20097" checksum="29181DF1BE4AA87B" modified="2014-10-29" version="1">MGSNIRRSRGYAFEHGLVERFNSLKEWHARRLGGSSTGLPDIVAVNNKQGILLTIEAKSGTSDILYVPQDQIERCIVVTEMFAIYPTRHIVFAFKFMSKKRFRRKNATVYEQRKLAEYYKVADALASMKPLPVVKCTYDGRTFAMLDGKTVELNLPDLPMPFQQHHNNNNDDGAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVL9</accession>
    <name>A0A075MVL9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVL9"/>
    <dbReference type="STRING" id="1459636.NTE_02659"/>
    <dbReference type="KEGG" id="nev:NTE_02659"/>
    <dbReference type="HOGENOM" id="CLU_2366066_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="95" mass="10207" checksum="A3E0BE20031B405C" modified="2014-10-29" version="1">MLKNTHRHPANKALHAVGLPIYAYGIAMIIGSFAGAGTDNALLGLGLWALAVSMLVAGHAIEGNVMSMTPVLLARLVFRSLCRVHLVEKRVHLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVU0</accession>
    <name>A0A075MVU0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03234</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701695.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVU0"/>
    <dbReference type="GeneID" id="41598889"/>
    <dbReference type="KEGG" id="nev:NTE_03234"/>
    <dbReference type="HOGENOM" id="CLU_2340287_0_0_2"/>
    <dbReference type="OrthoDB" id="372947at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="97" mass="11389" checksum="5B2122639699D975" modified="2014-10-29" version="1">MEHIIFHHNGKEYAVYDALTLDEIKTIMKMSDERDRKLNPLNSKSTRKYFEDTDKMVAAILRRCFRMTDSQISDIEQSERRSLASAFIRFLKSANGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVX9</accession>
    <name>A0A075MVX9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Carboxypeptidase regulatory-like domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03382</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVX9"/>
    <dbReference type="KEGG" id="nev:NTE_03382"/>
    <dbReference type="HOGENOM" id="CLU_884553_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1120">
        <property type="entry name" value="Carboxypeptidase-like, regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="Starch-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="314" mass="33890" checksum="357ACB5E9138A46C" modified="2014-10-29" version="1">MLKRMNNKISSTLLAVLIVASIASIAYTISGQPQKAYATNITISGRVVTSLNTSVANAKVYLEAPYQSGNGFLTPYEHAFTADAFGSFSISVPQGYTYTLDASKDGSSRARYPTTITTSTSGITLISNPQTTAILDLFVAPDDEFRSLYGVNSESTAWSKITSKEAVYRDNWNVHFNKKYYSTAWTSPSSTDMLTLLNDAASDTGWSSGSYQGADELLAITGISGTLYCGPDPASGCVPTPLPSTGGTHPKALVQEGTAITEAVNHELLHNYGFSHHTSNYYCIMNTGLWKDNDTAQPSYDDTMAISGSRRSWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVY2</accession>
    <name>A0A075MVY2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03269</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701728.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVY2"/>
    <dbReference type="GeneID" id="41598924"/>
    <dbReference type="KEGG" id="nev:NTE_03269"/>
    <dbReference type="HOGENOM" id="CLU_1187738_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="233" mass="27491" checksum="28B7760FB16A75D2" modified="2014-10-29" version="1">MEIPITSTYSSLADAAQELDKIIRQKGMVGNARTKVHYNGKFVQYSYGNENIHFEAWFGKKRPFIEIGLHIETSKNRNLVILNAMKRKSRQILKELPDAKFERWGRAWTKVYERIDWDGQLKSLDDGLLNELSRKLKLYVDTLKPLLEEINWGKSSKLSQKEIVRMFIVGEGDKRRCITTESLYKHVKRLPEFSGFGDEDWKRGHATWKAKQLTEEDPRHFRRKDKHTFCYVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MW00</accession>
    <name>A0A075MW00_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03402</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701843.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MW00"/>
    <dbReference type="STRING" id="1459636.NTE_03402"/>
    <dbReference type="GeneID" id="41599048"/>
    <dbReference type="KEGG" id="nev:NTE_03402"/>
    <dbReference type="HOGENOM" id="CLU_1048078_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="223"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="265" mass="26460" checksum="7C8C3694AE37B0DE" modified="2014-10-29" version="1">MKAAPLIGFVIIGGVAAYAIWRLASAKSAAASTPAGSGTPSPNNVQPLTVIVPAGDSGSTGGASAPIGIGPVDQQQVQAREEANTAIAENNEQVTGFAAGDKGPIPTIPVSFLTTQTNPVTGKEQAVFLRTDNGGVPAAAAFQFGENTVGFIEQVPFGAPSGAQNVIQLSPDQQFGFHQVSGGSGGPLKPGDPGYEQAVASARAKVAAVRAEQGAVETTDAKTGLTTITYTNTGASSKPASSSSEPASSSGLLSFLNVKNPARAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MW22</accession>
    <name>A0A075MW22_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative hydrocarbon binding protein (Contains V4R domain)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700254.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MW22"/>
    <dbReference type="STRING" id="1459636.NTE_01430"/>
    <dbReference type="GeneID" id="41597225"/>
    <dbReference type="KEGG" id="nev:NTE_01430"/>
    <dbReference type="eggNOG" id="arCOG01693">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG03932">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1048143_0_0_2"/>
    <dbReference type="OrthoDB" id="371687at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004096">
        <property type="entry name" value="V4R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35090">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35090:SF1">
        <property type="entry name" value="SLR0144 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02830">
        <property type="entry name" value="V4R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00989">
        <property type="entry name" value="V4R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4-vinyl reductase 4VR" evidence="1">
        <location>
            <begin position="201"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="266" mass="29452" checksum="D2B8F381C8DA0965" modified="2014-10-29" version="1">MQSPDAENAQSRRRWQDYGFIKEEVAKVLDGHPEGLTGARIAELVGITQGAMSKYLSMLKVDGIITSRKVGVAKLWKLVSQSDRAGILADKIGEADEEATFKDYAVSLLEENNRLFEADGKRVMVMPTSMLSNLYKYTKSVIGTEVHAFFYEWGKDYANEVNKLVDDVAKKTESDFIESFLLLWKLKGWGRFEIIAMDENAIEVAWYDSVLAEEMRGTEKAPVDDFVAGALAAAAAHSMGGSWRVTETSCRATGAPHCLFVGTKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MW31</accession>
    <name>A0A075MW31_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative flavoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_03329</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SsuE family. Isf subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701775.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MW31"/>
    <dbReference type="STRING" id="1459636.NTE_03329"/>
    <dbReference type="GeneID" id="41598979"/>
    <dbReference type="KEGG" id="nev:NTE_03329"/>
    <dbReference type="eggNOG" id="arCOG04624">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055322_1_2_2"/>
    <dbReference type="OrthoDB" id="9059at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050712">
        <property type="entry name" value="NAD(P)H-dep_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30543">
        <property type="entry name" value="CHROMATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30543:SF21">
        <property type="entry name" value="NAD(P)H-DEPENDENT FMN REDUCTASE LOT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADPH-dependent FMN reductase-like" evidence="2">
        <location>
            <begin position="8"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF85358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="198" mass="21793" checksum="7C810EC4B6A70303" modified="2014-10-29" version="1">MSISNELKVLGVAGSMREGSYSKRALRVALESAKRHGAQVRLLELSKADLPMYASLGAGSSQALAKVAADVEWADAFMLASPDYHGSISGALKNFLDHFYEEFAGKVFGYIVASHEKGLTVMDQMRTAVRQCYGWSLPYGVSINSEQDFTSGQLSNTRIEQRLNMMGRDLVTYGRVIRGQFLQDLAGSDSETFAARYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MW48</accession>
    <name>A0A075MW48_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 7">16S rRNA aminocarboxypropyltransferase</fullName>
            <ecNumber evidence="7">2.5.1.157</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NTE_01455</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>an N(1)-methylpseudouridine in rRNA + S-adenosyl-L-methionine = N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine in rRNA + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63296"/>
            <dbReference type="Rhea" id="RHEA-COMP:11634"/>
            <dbReference type="Rhea" id="RHEA-COMP:16310"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74890"/>
            <dbReference type="ChEBI" id="CHEBI:146234"/>
            <dbReference type="EC" id="2.5.1.157"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TDD superfamily. TSR3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.157" evidence="7"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MW48"/>
    <dbReference type="STRING" id="1459636.NTE_01455"/>
    <dbReference type="KEGG" id="nev:NTE_01455"/>
    <dbReference type="eggNOG" id="arCOG04733">
        <property type="taxonomic scope" value="Archaea"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="PRK02287.1"/>
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    </dbReference>
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        <property type="entry name" value="18S RRNA AMINOCARBOXYPROPYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN TSR3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04034">
        <property type="entry name" value="Ribo_biogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4 7" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="16S/18S rRNA aminocarboxypropyltransferase Tsr3 C-terminal" evidence="8">
        <location>
            <begin position="41"/>
            <end position="166"/>
        </location>
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        <location>
            <position position="20"/>
        </location>
        <ligand>
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        </ligand>
    </feature>
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        <location>
            <position position="65"/>
        </location>
        <ligand>
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        </ligand>
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        <location>
            <position position="90"/>
        </location>
        <ligand>
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        </ligand>
    </feature>
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        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00014114"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="HAMAP-Rule" id="MF_01116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF83519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="171" mass="19120" checksum="B6B5A3524543DBD6" modified="2014-10-29" version="1">MQHVKPQVYMMRQDDPFKCTAAKLAKFKIAEPVKFIRKDAIVLNPFSETLLTKNDAGIASSVCAVDCSWERADDVAKHQRVFSAGIGRRLPAMLAANPTNYAKLGKLSSAEALAGALYILGDRQTAAEIMNKFKWGHTFLELNANLLEDYSSAETQEQMMQTELEYFPNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MW77</accession>
    <name>A0A075MW77_9ARCH</name>
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        <submittedName>
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        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
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            <taxon>Nitrososphaerales</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="3">Alkylhydroperoxidase AhpD family core domain</fullName>
        </recommendedName>
    </protein>
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        <name evidence="1" type="ORF">NTE_03537</name>
    </gene>
    <organism evidence="1 2">
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        <lineage>
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            <taxon>Nitrososphaerales</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
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        <property type="entry name" value="4-CARBOXYMUCONOLACTONE DECARBOXYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G11590)"/>
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    </dbReference>
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        <property type="entry name" value="CYTOPLASMIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="199" mass="22739" checksum="0188D40799AC0988" modified="2014-10-29" version="1">MKETQRPQQQITTAAASPFLSPIEEPQDPIMKQAYDTTLQQFGKILTPVKVFNARMPPEFWQLAAKIGELAEKLTLPKETAFLVQQHVSNMNICSFCIDIGRAVTIKASMNQAKFDALEEYRTSPLFTDAERAVLDYVTELTRNKAVNPETFARMAKYYSEREICEIVWLVASEHLYNMTNIGLNIHSDMLCDISKRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWG7</accession>
    <name>A0A075MWG7_9ARCH</name>
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        <submittedName>
            <fullName evidence="11">Flavodoxin reductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NTE_03445</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
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            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
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    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SR1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
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        <property type="protein sequence ID" value="AIF85473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWG7"/>
    <dbReference type="STRING" id="1459636.NTE_03445"/>
    <dbReference type="GeneID" id="41599083"/>
    <dbReference type="KEGG" id="nev:NTE_03445"/>
    <dbReference type="eggNOG" id="arCOG02200">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG02852">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_709037_0_0_2"/>
    <dbReference type="OrthoDB" id="35401at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00322">
        <property type="entry name" value="FNR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050415">
        <property type="entry name" value="MRET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47354">
        <property type="entry name" value="NADH OXIDOREDUCTASE HCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47354:SF6">
        <property type="entry name" value="NADH OXIDOREDUCTASE HCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="9">
        <location>
            <begin position="5"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="10">
        <location>
            <begin position="134"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AIF85473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="389" mass="43308" checksum="ED32B5F5A942A1E0" modified="2014-10-29" version="1">MTRYNTTFRKADLQERKPVRVDIDGKAIVLALVSGKIYAMDAVCSHEGGPLEEGSIEEYSLICPWHQGIFDIRTAKASPETDWVTDLRSYRVEVEEKSGLIAIDTDSGASHSDSGSSPRIARQENAVAVDDVPARPLKFELKLLEKVSQKGTDIMSFRFSRSDSENYLNYKAGQYSIVDLGTREDPEGPTRSFTIASSPTEKEGILISTRIRDTPFKQKLSKLDIGASVKITAPAGKFTLPEDNSSPVVLLTGGGGVTPFRSMIKYATDKQLALKITMFDSNRNRANVLYKDEFDRWANLNKNLKIIYTITGEQEQPETPQSLTTPEWIDEKGMINKAMLARHLSIDELKDSIFYTCGPPAMLNAMRKLLSEEIGVSGDRIRTEAFTGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MX86</accession>
    <name>A0A075MX86_9ARCH</name>
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        </submittedName>
    </protein>
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            <taxon>Nitrososphaerota</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
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    </dbReference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="51" mass="5637" checksum="B8D9D09272A49D91" modified="2014-10-29" version="1">MQILGMDTEKTEEIAGGEIVCDQCGKRPAEIFQVTGDYCVECWQAITHTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MX98</accession>
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        <name evidence="2" type="ORF">NTE_03218</name>
    </gene>
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        <lineage>
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        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <dbReference type="GeneID" id="43502675"/>
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            <begin position="31"/>
            <end position="46"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="AIF85247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="54" mass="5905" checksum="2CDA28B4F4C02480" modified="2014-10-29" version="1">MVSQKKAIGILGIVFAVAGGAAWFYGQHIPAAILWGAAVLIVMKLNKRQQQKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MXH0</accession>
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    <organism evidence="2 3">
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
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    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MXH0"/>
    <dbReference type="STRING" id="1459636.NTE_01946"/>
    <dbReference type="GeneID" id="43502629"/>
    <dbReference type="KEGG" id="nev:NTE_01946"/>
    <dbReference type="HOGENOM" id="CLU_3057257_0_0_2"/>
    <dbReference type="OrthoDB" id="376036at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="56" mass="6048" checksum="9F9A64C30A226D1E" modified="2014-10-29" version="1">MVEKMTAVWLIVLTIIVCAAVPGMLIYITLPHATTAKMLTGLPLVESMNHVLAISQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MXK6</accession>
    <name>A0A075MXK6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Kef-type K+ transport system, membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">NTE_01976</name>
    </gene>
    <organism evidence="13 14">
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        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
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            <taxon>Nitrososphaerales</taxon>
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        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700687.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MXK6"/>
    <dbReference type="STRING" id="1459636.NTE_01976"/>
    <dbReference type="GeneID" id="41597724"/>
    <dbReference type="KEGG" id="nev:NTE_01976"/>
    <dbReference type="eggNOG" id="arCOG01953">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005126_7_1_2"/>
    <dbReference type="OrthoDB" id="12029at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43562">
        <property type="entry name" value="NAPA-TYPE SODIUM/HYDROGEN ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43562:SF3">
        <property type="entry name" value="SODIUM ION_PROTON EXCHANGER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="9" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
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            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
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            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
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            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="227"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
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            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
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            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="12">
        <location>
            <begin position="18"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="414"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIF84034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="424" mass="44822" checksum="66DEE646B54F96F6" modified="2014-10-29" version="1">MAAEELFVSVIIILVAARVLGELFQRIKQPPLIGEILAGVLIGPSVLGIVQHGPSLDVLSDLAVFFLMLLAGLEMDPKEIRRVGKYAIVISLIAFFVPFASGTLVAQAFGLALSQSLFMGLLLSITAVPVSAIVLMQFGILRSKLGNIVITAAVINDILSLVVLSIVLQIGAEGSAGQVVMDVGAIAWSGAKIAAFLAGIFLFDLLLRSTSHWLPARVEPYFKKLQTKEAAFGILLITTIAVSLIAQDIGLHFVIGTFFSGLIIYKEIIGKQNFDRVYNIISAITFGFFAPIFFAIIGIDMDLKSLVNAIPLFLALLAVAVAAKIGGSYLGARLVRFSKDTSIAIGFLMNGRGMVELVIASIGFAAGIIDITLFSVAVAIGFATTIMAPITAKPFVARAKERDKTSVEAQSDGDGSGGQATYGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MXN4</accession>
    <name>A0A075MXN4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03343</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MXN4"/>
    <dbReference type="KEGG" id="nev:NTE_03343"/>
    <dbReference type="eggNOG" id="arCOG08770">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116583_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="200" mass="22372" checksum="B16C983808D93CF1" modified="2014-10-29" version="1">MLATITPPPSKKVWIFPGTGGTLRKRGKYQRFIIACMAQQACSSITKRVLAKQMAKRFGMSLRNAYTHTYMELNDSLIPGGIVEQDGAVPATRGPRIFQVNGVPCFRLSGLGMLLACCLEEIDINERMALFRQYIDSDRSWRQDSRKGELLSHLEAYPEFTLELLKHGAAQYLEGKIDHPLSILPTRRRQNPTAASSSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MXU8</accession>
    <name>A0A075MXU8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF488 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03414</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MXU8"/>
    <dbReference type="STRING" id="1459636.NTE_03414"/>
    <dbReference type="KEGG" id="nev:NTE_03414"/>
    <dbReference type="eggNOG" id="arCOG06027">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_137928_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052552">
        <property type="entry name" value="YeaO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36849:SF1">
        <property type="entry name" value="CYTOPLASMIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36849">
        <property type="entry name" value="CYTOPLASMIC PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22752">
        <property type="entry name" value="DUF488-N3i"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="132" mass="15795" checksum="171E420C889F1F2B" modified="2014-10-29" version="1">MLLSEVSITTLEIQRIYDMKKHAAREEEERSFKIFVDRLWARGIRKEDITVDLWLKDIAPSDSLRKWFGHDPRKWNEFKKRYFKELDGKKEPVELILQRLRSGTPVLLLYGAKDEKFNNAVALKEYLLRQAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MYU7</accession>
    <name>A0A075MYU7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MYU7"/>
    <dbReference type="STRING" id="1459636.NTE_02387"/>
    <dbReference type="KEGG" id="nev:NTE_02387"/>
    <dbReference type="HOGENOM" id="CLU_1357860_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="201" mass="22904" checksum="2A29A1D74A24C9CB" modified="2014-10-29" version="1">MEVCLVVMSSLTGNKKNVLTVAILAMGFVLASSAIGLPTAAFATSGHDDNRHDDDNNCDYSNSDYHWSSYGDDKNSRDDDNSCDCNDNNDDNNDDNGHDYSSDYNHDNNCDCSSNDDNGDYHWSSYDSNGDDNCDDNSGHDSHDYSGHYDYSHDNGHDYKDSKHDDYRNHDNYDKHDSKDDRHDSDYSRYDNRDDYKGKNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MZX2</accession>
    <name>A0A075MZX2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable transcription termination protein NusA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nusA</name>
        <name evidence="9" type="ORF">NTE_02747</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Participates in transcription termination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NusA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701302.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MZX2"/>
    <dbReference type="STRING" id="1459636.NTE_02747"/>
    <dbReference type="GeneID" id="41598436"/>
    <dbReference type="KEGG" id="nev:NTE_02747"/>
    <dbReference type="eggNOG" id="arCOG01760">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131906_0_0_2"/>
    <dbReference type="OrthoDB" id="4116at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22530">
        <property type="entry name" value="KH-II_NusA_arch_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22531">
        <property type="entry name" value="KH-II_NusA_arch_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.20:FF:000024">
        <property type="entry name" value="Probable transcription termination protein NusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00945_A">
        <property type="entry name" value="NusA_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010212">
        <property type="entry name" value="NusA_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030842">
        <property type="entry name" value="TF_NusA_bacterial"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01952">
        <property type="entry name" value="nusA_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22648">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR NUSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22648:SF0">
        <property type="entry name" value="TRANSCRIPTION TERMINATION_ANTITERMINATION PROTEIN NUSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="Prokaryotic type KH domain (KH-domain type II)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 6" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="K Homology" evidence="8">
        <location>
            <begin position="33"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF84789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="161" mass="17688" checksum="3FEC7D8FBA083EB7" modified="2014-10-29" version="1">MTEIKLTSDELRLISLFGSVTSASARDCIVDDKMDRVIFVVNKGQMGLAIGKGGATIKQLQQVVGRKVELVEFSEDPAEFIRNMLNADMVSDVRISERMDGSKQAVVTVDAKKKGAVVGREGRNAEKARLLAKRYFNISSVLIVSPEQQITTNNRVNMNNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N0T3</accession>
    <name>A0A075N0T3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03044</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N0T3"/>
    <dbReference type="STRING" id="1459636.NTE_03044"/>
    <dbReference type="KEGG" id="nev:NTE_03044"/>
    <dbReference type="eggNOG" id="arCOG08654">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_161800_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="136" mass="15119" checksum="F2AC90317508514F" modified="2014-10-29" version="1">MRVRCCRVAGADSFAVERGKGEKAVAWMNEYAKKNNIKFEAKLKEGHTMSTVKFGGFEFISWKGEWPAARNIIKRASGKLGVKTLESGYHEKKDLLASMFGSSSEFAKVYSNGNLVGQLEMSLKGGKWVVKNEVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N1Y4</accession>
    <name>A0A075N1Y4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03436</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N1Y4"/>
    <dbReference type="KEGG" id="nev:NTE_03436"/>
    <dbReference type="eggNOG" id="arCOG04926">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1269865_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="217" mass="24772" checksum="4E21F9CC73DCFDB7" modified="2014-10-29" version="1">MRPSSRREIIPISILIALLLLFLRNKMEGKPYDRQIKPFNFCIVGVGNFTDPDTGEVIKPLAPFRKDAQVCAYEDFIDYNSDKMLKGQHYWKKFSGVVRDYANHREAKFDGSKGILTRKHIRVSSVVHIGKESNDLEVSEVLGVNDDTTLAYSSISQKMSENKERIIATPPSRVRQFGIIKETWLRIQRLLKAGRIPTLHGKTAEAMMKFLRSDVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLF6</accession>
    <name>A0A075MLF6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00189</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158384908.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLF6"/>
    <dbReference type="GeneID" id="43502542"/>
    <dbReference type="KEGG" id="nev:NTE_00189"/>
    <dbReference type="HOGENOM" id="CLU_3038859_0_0_2"/>
    <dbReference type="OrthoDB" id="379386at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="54" mass="6489" checksum="65AF9E4C8646BE48" modified="2014-10-29" version="1">MNRNNEFEKLNDRKATYLIVDDDTIVNLKNYYKLEDHDELLQFIKDVVIVGDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLL0</accession>
    <name>A0A075MLL0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00274</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLL0"/>
    <dbReference type="STRING" id="1459636.NTE_00274"/>
    <dbReference type="KEGG" id="nev:NTE_00274"/>
    <dbReference type="HOGENOM" id="CLU_3112873_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="50" mass="6083" checksum="8B541CAADDCDC002" modified="2014-10-29" version="1">MRYYDPAPIESNGVLMTAYYEYYIIQHILFRFFSFSVRDFCNFGRSLLQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLQ9</accession>
    <name>A0A075MLQ9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLQ9"/>
    <dbReference type="KEGG" id="nev:NTE_00349"/>
    <dbReference type="HOGENOM" id="CLU_2629524_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="77" mass="8584" checksum="6BE7B5768A1C6BE4" modified="2014-10-29" version="1">MVGGIAQIFWILPILRRWGKVWYSIGIAGTTVFIAIWTITRMPGNPITHRAGDLDAIDIVTEALQLAFIGFSLLSWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLZ0</accession>
    <name>A0A075MLZ0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLZ0"/>
    <dbReference type="KEGG" id="nev:NTE_00176"/>
    <dbReference type="HOGENOM" id="CLU_1280836_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="207" mass="21758" checksum="9D3451E3E8285CC0" modified="2014-10-29" version="1">MLRVVMKTTLVITSLVILAGFATAIVAVPMMMTTAAYAQQSQQQQVPGYNYFYPVPPMNGTTPQPPADNGTSTTPPPEDNGTTTMPPPEDNNTSPLPPPGNNTQSDESSIFISAHNIHSAEIGDGIIGVRVLPPTPGFEWDGDIIWQATGNVTLIAIQSDGTTTVSQEATASALHFTAAALEFQSVTGEPVDVTYSVQAHLQAVPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MM19</accession>
    <name>A0A075MM19_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTPase HflX</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GTP-binding protein HflX</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hflX</name>
        <name evidence="10" type="ORF">NTE_00449</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer. Associates with the 50S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="5">May associate with membranes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699484.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MM19"/>
    <dbReference type="STRING" id="1459636.NTE_00449"/>
    <dbReference type="GeneID" id="41596325"/>
    <dbReference type="KEGG" id="nev:NTE_00449"/>
    <dbReference type="eggNOG" id="arCOG00353">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019597_2_0_2"/>
    <dbReference type="OrthoDB" id="10150at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:ribosome binding"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006809">
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    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hflx-type G" evidence="9">
        <location>
            <begin position="189"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="155"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="195"/>
            <end position="202"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="220"/>
            <end position="224"/>
        </location>
        <ligand>
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        </ligand>
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            <position position="222"/>
        </location>
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        </ligand>
    </feature>
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        <location>
            <begin position="241"/>
            <end position="244"/>
        </location>
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        </ligand>
    </feature>
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        <location>
            <begin position="309"/>
            <end position="312"/>
        </location>
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        </ligand>
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        <location>
            <begin position="338"/>
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        </location>
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        </ligand>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AIF82531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="379" mass="42369" checksum="C74E1AD3B48451D1" modified="2014-10-29" version="1">MSADFHRKAILITYPYDEAISEAVSLADAAGYRVEKIVTQKHITKSRYGIGLGKAEEVKAIAEEIQPEVIVFDEVLKPSQTYNLASVCKKEVIDRERLILEIFERRASTTESKTQIKLAQLRYDMTRAREAVRLAKAGEQPGFYGLGKYEADAYLLDIKNRAQALKKKLEKEVTKRQLHRNQRAKAGLMSISLAGYTSAGKTTLFNALTGEAKSTASSVFTTLSTFTRAIDLDGDKVLLLDTVGFISKLPAYMIDAFKSTLEELSYANLVFLVIDISEPILEIRRKLASSLEVIREFEVPETRIVYVLNKADKTTDEDAFDKAGQLGLLASRRVLPVSAKTGYNMDQLKSLARSLLFETEEIKEDNEEEKTSDGAQDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MM57</accession>
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            <fullName evidence="3">Response regulatory domain-containing protein</fullName>
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    </gene>
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        <lineage>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="77" mass="8794" checksum="FD78B00AEF1F19BC" modified="2014-10-29" version="1">MYKEMRRKKKKKEGLVNSSNNNVVIFTASSISDENIEWMLNDNTKMVLSKPVSQDDLQSVVTKFVVSGQPGKKMWEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MME0</accession>
    <name>A0A075MME0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Plastocyanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00218</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
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        <property type="entry name" value="Cupredoxins"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="151" mass="15842" checksum="6AE50F602732FAE1" modified="2014-10-29" version="1">MTDRKFVLFSSLPIAILSSLVVIFAASLHLANAQSIPADSGIGVVDTSPNAAVIIIDTDASGNIVFKPNNVTIKIGEEILILNNSTSPQSFTSGKSSNDPTSGTMFDTGLIQPKQFTEYTAANLREGQYPFYSTAAPTTATGTLTIVAAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMG6</accession>
    <name>A0A075MMG6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00361</name>
    </gene>
    <organism evidence="1 2">
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
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    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMG6"/>
    <dbReference type="GeneID" id="41596253"/>
    <dbReference type="KEGG" id="nev:NTE_00361"/>
    <dbReference type="eggNOG" id="arCOG08805">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100103_1_0_2"/>
    <dbReference type="OrthoDB" id="9412at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="174" mass="19915" checksum="70A641A417046480" modified="2014-10-29" version="1">MESTSVTFRVLNKKLESLRTLAEDSKMSLNTLVNNIIDSYLEWEFLAPKVGFVPMQKSVLKDLFDRVSEEEIKEIATRAADNFENELIMLYGKVDLESVISFTKNRVKKSGFTLREFDSGEKGARKLVMHHDVGHNWSVFSMTYIERLINNVGYKTKIQATDNTLTIEILDPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMN8</accession>
    <name>A0A075MMN8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00328</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158384948.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMN8"/>
    <dbReference type="GeneID" id="43502553"/>
    <dbReference type="KEGG" id="nev:NTE_00328"/>
    <dbReference type="HOGENOM" id="CLU_3056945_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="53" mass="5845" checksum="AF1D64F6BB5F2965" modified="2014-10-29" version="1">MTADKIYENLKALGVNIDAVKNCSPTIDELKQFHNGILSILERHQGNAQAYAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMN9</accession>
    <name>A0A075MMN9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MarR family transcriptional regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00451</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMN9"/>
    <dbReference type="STRING" id="1459636.NTE_00451"/>
    <dbReference type="KEGG" id="nev:NTE_00451"/>
    <dbReference type="HOGENOM" id="CLU_2327134_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="98" mass="11125" checksum="23F5FA14F75646F6" modified="2014-10-29" version="1">MKPSDKPIGFWLKHLHNLIEAHFEADLADYRMTRRHWQILNLLSSGQRSRTEALQSLAPFWDDATQSLDALLDGPDGMIARHWVRSDDGATGILALTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMR2</accession>
    <name>A0A075MMR2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00048</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699194.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMR2"/>
    <dbReference type="STRING" id="1459636.NTE_00048"/>
    <dbReference type="GeneID" id="41595999"/>
    <dbReference type="KEGG" id="nev:NTE_00048"/>
    <dbReference type="HOGENOM" id="CLU_196478_0_0_2"/>
    <dbReference type="OrthoDB" id="376071at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="83" mass="8931" checksum="DA7C65FF2DC0048E" modified="2014-10-29" version="1">MQVVTATTTAAITGSERHFALCESCFWSATVFGKNNNNNLLPACPSCMGENVSLIPLSKDEEYQVRVSPSAGVEMSFSRAKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMW2</accession>
    <name>A0A075MMW2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00701</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMW2"/>
    <dbReference type="KEGG" id="nev:NTE_00701"/>
    <dbReference type="HOGENOM" id="CLU_1507318_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="178" mass="21133" checksum="B24946BFE74A4096" modified="2014-10-29" version="1">MFCKGVHFRNREPCSSALDLYLLSLVDLVIYYDRRRSKGDQKRDLPEICGVLKWELNSRILLRWLCYSDLHMLAKKASLRRPKFFLFIREFLTRRTFTFGMDGMARNSSYPIMLSAIYPALTLYTVIHGMLKCLRFMLPLPFNRHGRGYNNYPLITALKAFFIWYFCRSALWPSSVYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MN04</accession>
    <name>A0A075MN04_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein eS31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rps27ae</name>
        <name evidence="8" type="ORF">NTE_00783</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the eukaryotic ribosomal protein eS31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699748.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MN04"/>
    <dbReference type="STRING" id="1459636.NTE_00783"/>
    <dbReference type="GeneID" id="41596633"/>
    <dbReference type="KEGG" id="nev:NTE_00783"/>
    <dbReference type="eggNOG" id="arCOG04183">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_179743_2_0_2"/>
    <dbReference type="OrthoDB" id="25142at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00777">
        <property type="entry name" value="Ribosomal_eS31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002906">
        <property type="entry name" value="Ribosomal_eS31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022845">
        <property type="entry name" value="Ribosomal_eS31_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038582">
        <property type="entry name" value="Ribosomal_eS31_euk-type_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001669">
        <property type="entry name" value="PRK00432.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01599">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01402">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Small ribosomal subunit protein eS31" evidence="7">
        <location>
            <begin position="14"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF82861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="69" mass="7820" checksum="98E7409313A19162" modified="2014-10-29" version="1">MADKKAPAKGEVAVYKFYKVEGNKVTRNKRECLKCGKGVFMAEHKDRFTCGKCGYTEFARKEAPKKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MN07</accession>
    <name>A0A075MN07_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cyclic dehypoxanthine futalosine synthase</fullName>
            <shortName evidence="6">Cyclic DHFL synthase</shortName>
            <ecNumber evidence="6">1.21.98.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Dehypoxanthine futalosine cyclase</fullName>
            <shortName evidence="6">DHFL cyclase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Menaquinone biosynthetic enzyme MqnC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mqnC</name>
        <name evidence="10" type="ORF">NTE_00788</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>dehypoxanthine futalosine + S-adenosyl-L-methionine = cyclic dehypoxanthinylfutalosinate + 5'-deoxyadenosine + L-methionine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33083"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58864"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64270"/>
            <dbReference type="EC" id="1.21.98.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6 7">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6 7">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the radical SAM superfamily. MqnC family.</text>
    </comment>
    <dbReference type="EC" id="1.21.98.1" evidence="6"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MN07"/>
    <dbReference type="STRING" id="1459636.NTE_00788"/>
    <dbReference type="KEGG" id="nev:NTE_00788"/>
    <dbReference type="eggNOG" id="arCOG00656">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040406_1_0_2"/>
    <dbReference type="OrthoDB" id="8186at2157"/>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044689">
        <property type="term" value="F:7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046992">
        <property type="term" value="F:oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00992">
        <property type="entry name" value="MqnC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045567">
        <property type="entry name" value="CofH/MnqC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022431">
        <property type="entry name" value="Cyclic_DHFL_synthase_mqnC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034405">
        <property type="entry name" value="F420"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020050">
        <property type="entry name" value="FO_synthase_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00423">
        <property type="entry name" value="CofH family radical SAM protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03699">
        <property type="entry name" value="menaquin_MqnC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43076">
        <property type="entry name" value="FO SYNTHASE (COFH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43076:SF1">
        <property type="entry name" value="LIPOYL SYNTHASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19288">
        <property type="entry name" value="CofH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004762">
        <property type="entry name" value="CHP00423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00343">
        <property type="entry name" value="aminofutalosine_synthase_(mqnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00342">
        <property type="entry name" value="cyclic_dehypoxanthine_futalosi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01064">
        <property type="entry name" value="F420__menaquinone_cofactor_bio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01389">
        <property type="entry name" value="menaquinone_synthsis_involved"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6 7" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6 7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="9">
        <location>
            <begin position="62"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>(3R)-3-methyl-D-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:64642"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>(3R)-3-methyl-D-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:64642"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR004762-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR004762-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIF82866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="375" mass="41871" checksum="2D2DA7749E57F6E7" modified="2014-10-29" version="1">MQGRLLQEFLSKSDISDVLDSALAGQRPLGLDDCIRLVKSDDAYSMGLVANILRHRLFGDRITFVNNIILNYTNVCVTYCKFCAFYRPPGHEESYTVPKEEIVRRVATSREMFGITQVLIQGGHNPNLKIEYYEDAFKAMKEKCPEVGIHGLSPSEVDMIAKVERSSTKEVLARLKAAGMDTFAGAGAEILEDSVKEQISPLKIKSDEWLRIMEEAHNVGLKSVATMMYGTIETEEDRARHILKIMKLQEKTGGFVCFIPWSFEPNNTEMQAEGLIKYPSGGLQLLKMIAISRIMFYGLIDHLQSSWLTNGIGMAQLALNHGADDFGGTLIGEEVVSATGARSTELTSDRIIAAIKQAGYRPAERDNLYRTVRQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MN47</accession>
    <name>A0A075MN47_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Plastocyanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699252.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MN47"/>
    <dbReference type="STRING" id="1459636.NTE_00130"/>
    <dbReference type="GeneID" id="41596070"/>
    <dbReference type="KEGG" id="nev:NTE_00130"/>
    <dbReference type="HOGENOM" id="CLU_926277_0_0_2"/>
    <dbReference type="OrthoDB" id="4392at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052721">
        <property type="entry name" value="ET_Amicyanin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36507">
        <property type="entry name" value="BLL1555 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36507:SF1">
        <property type="entry name" value="BLL1555 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="302" mass="31846" checksum="09488FAAE9F68063" modified="2014-10-29" version="1">MSKFKHGSAVLAAATLLAITSSLLLAASLQSAFSQTTSSTTTSFNPQPGYSQAREDPSFAVHIPFTDLGFSPFLPTTISIPTGMTVIWFNEDESEHSVTVDAGSPGVPQGAEFDSDMIAPGGFFTHTFTVPGTYEYHDSANPQSKGRINVGSGFEGGSNMDMLIGGNALPFNSSKLARVTLSFVPHESAAVIPPDLSITYNVTISNSASAMYSNQFEDSDGILDLELVPAISRTNSTANFVTWGPDLTDNEGVASDGTYHVQGPVLVNDEEYSIQVSIVAENESDLSSPVSDTFVLPPVGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MN78</accession>
    <name>A0A075MN78_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699279.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MN78"/>
    <dbReference type="GeneID" id="41596101"/>
    <dbReference type="KEGG" id="nev:NTE_00170"/>
    <dbReference type="HOGENOM" id="CLU_2820603_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="66" mass="7699" checksum="7B471545547473C5" modified="2014-10-29" version="1">MTAYTIVPHSRAYNKAFSINLYRYKGACQKCRQTINFGDIIISKSSSKNTKYYHEKCARKVMILDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MN95</accession>
    <name>A0A075MN95_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699294.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MN95"/>
    <dbReference type="GeneID" id="41596116"/>
    <dbReference type="KEGG" id="nev:NTE_00190"/>
    <dbReference type="HOGENOM" id="CLU_181205_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="93" mass="10752" checksum="1CB256E69A69F8CF" modified="2014-10-29" version="1">MPPWVENGLIEKLVANEVAEKQGNDIVFTKPFSVFMIDSVNHQTSLKTIDECRNVMRRYNSALRYLSDHEVRAAMVLLGFYIEHMDKRIPAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNE0</accession>
    <name>A0A075MNE0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosomal RNA large subunit methyltransferase E</fullName>
            <ecNumber evidence="5">2.1.1.166</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">23S rRNA Um2552 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">rRNA (uridine-2'-O-)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rlmE</name>
        <name evidence="8" type="ORF">NTE_00648</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>uridine(2552) in 23S rRNA + S-adenosyl-L-methionine = 2'-O-methyluridine(2552) in 23S rRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42720"/>
            <dbReference type="Rhea" id="RHEA-COMP:10202"/>
            <dbReference type="Rhea" id="RHEA-COMP:10203"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74478"/>
            <dbReference type="EC" id="2.1.1.166"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.166" evidence="5"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699641.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNE0"/>
    <dbReference type="STRING" id="1459636.NTE_00648"/>
    <dbReference type="GeneID" id="41596511"/>
    <dbReference type="KEGG" id="nev:NTE_00648"/>
    <dbReference type="eggNOG" id="arCOG00079">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009422_4_4_2"/>
    <dbReference type="OrthoDB" id="26307at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008650">
        <property type="term" value="F:rRNA (uridine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF13">
        <property type="entry name" value="PRE-RRNA 2'-O-RIBOSE RNA METHYLTRANSFERASE FTSJ3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005461">
        <property type="entry name" value="23S_rRNA_mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="7">
        <location>
            <begin position="20"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5 6">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR005461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF82728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="200" mass="22032" checksum="D53B94A0C516EC1C" modified="2014-10-29" version="1">MRLADARRDHYRRLAKDQGYRSRAAYKLKQINDSYRILRRGNRIVDIGCAPGGWVQVATEEVGPGNNKVVGIDLKEVEPVAGATILQGSIDDPVAVRKIIEALGEEKADVVLSDLAPNVSGMWEVDHARQIDLTRSALALAKQVLKGGGSAVFKVFEGEFLNELKNEMKASFAKVLISKPTASRQESSELYLVCIGFRHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNQ3</accession>
    <name>A0A075MNQ3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Threonine--tRNA ligase</fullName>
            <ecNumber evidence="13">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Threonyl-tRNA synthetase</fullName>
            <shortName evidence="13">ThrRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">thrS</name>
        <name evidence="15" type="ORF">NTE_00680</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>tRNA(Thr) + L-threonine + ATP = L-threonyl-tRNA(Thr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 13">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="13"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699666.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNQ3"/>
    <dbReference type="STRING" id="1459636.NTE_00680"/>
    <dbReference type="GeneID" id="41596537"/>
    <dbReference type="KEGG" id="nev:NTE_00680"/>
    <dbReference type="eggNOG" id="arCOG00401">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029833_0_0_2"/>
    <dbReference type="OrthoDB" id="372136at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00860">
        <property type="entry name" value="ThrRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000076">
        <property type="entry name" value="Threonine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000001">
        <property type="entry name" value="Threonine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.80.10">
        <property type="entry name" value="D-tyrosyl-tRNA(Tyr) deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00184">
        <property type="entry name" value="Thr_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023509">
        <property type="entry name" value="DTD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015011">
        <property type="entry name" value="Threonyl-tRNA_syn_edit_dom_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047246">
        <property type="entry name" value="ThrRS_anticodon"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003068">
        <property type="entry name" value="PRK03991.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451:SF44">
        <property type="entry name" value="THREONINE--TRNA LIGASE, CHLOROPLASTIC_MITOCHONDRIAL 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="THREONINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08915">
        <property type="entry name" value="tRNA-Thr_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13 15" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 13 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 13" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="7 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="14">
        <location>
            <begin position="212"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="480"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AIF82760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="631" mass="72291" checksum="2DA93515E9B76436" modified="2014-10-29" version="1">MRLLQLHSDFIEYEPIEKEIKSAEEIQSKAKVRLEDLVVAFVAVETGDDESVAKAAAGEIKKYMDTVKASRLLVYPYAHLSSDLAAPDVAAGVVRAVESYARESASEVHRSPFGWTKSFNIKVKGHPLAENAKAISKQAGAAEEVHLHEHDEGKESTALKNEEKLKSFWYILQPGGTLTPVGEYKFKKQDASLQTLANYEISKNRAVNQQPEHVRLMKKMAIADYEPASDVGNMRFYPKGRLMKSLIEQYVTRRVMEYGGIEVETPIMYDSKHPSMESYFNRFPARQYNIQSDNKQLFLRFAACFGQFLIAKDMNVSYKHMPFKLYELTRYSFRREKSGELVGLRRLRAFTMPDCHAFCKDLAQAKEEFRKRFELSISVLNALGLQNEDVEMAIRFTEDFWNENKDFITELINRFGRPVLAEVWKERFFYFTLKWEFNYVDGLGKASALSTDQIDVENGKRYGIEYVDEDGTKKNPIILHNSPSGAVERVMYALMEKAAKVSKTGGIPSFPLWLAHTQVRIISVAKEHLQFCDNLLAQLSANQIRADVDDRDESVGKKIRESETEWIRYTIVIGDKEVASGKLVVRDRNEGKQREMTVQELIDEVKAQTKDKPYLPLNLPRYVSVRPQIMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNS0</accession>
    <name>A0A075MNS0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNS0"/>
    <dbReference type="KEGG" id="nev:NTE_00780"/>
    <dbReference type="HOGENOM" id="CLU_1933333_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="144" mass="16320" checksum="5DEA26692107ED1D" modified="2014-10-29" version="1">MYMPSLMAHRRATFALLTLGFAIASLAIVAMPTAAFASSNGYNKDDKDFVVCVFKDDNNKDDDDNDNNNDYQWSSYNKDNSNDDDDDNDNNDNSCVCFSKDDNNDNKDDYQWSSYSKDDENGKDTIVCILHNNNNDNNNNDNGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNT0</accession>
    <name>A0A075MNT0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNT0"/>
    <dbReference type="KEGG" id="nev:NTE_00790"/>
    <dbReference type="HOGENOM" id="CLU_196477_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="58" mass="6329" checksum="97720549FE61F785" modified="2014-10-29" version="1">MKRRLMIINIAALAAMFVAVVNLVTLREVWVLAAAVAVLVGLAVYSVNEKFKLKKQSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNT8</accession>
    <name>A0A075MNT8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Activator of Hsp90 ATPase homologue 1/2-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_01133</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNT8"/>
    <dbReference type="STRING" id="1459636.NTE_01133"/>
    <dbReference type="KEGG" id="nev:NTE_01133"/>
    <dbReference type="HOGENOM" id="CLU_108923_1_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd08897">
        <property type="entry name" value="SRPBCC_CalC_Aha1-like_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="ASHA1/2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Activator of Hsp90 ATPase homologue 1/2-like C-terminal" evidence="2">
        <location>
            <begin position="29"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF83206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="156" mass="17851" checksum="E99ACAF0FEE3C375" modified="2014-10-29" version="1">MEIKRLYLLTNTISFMDTKKTIAVQAVINAPVEKVWKLWTAPEHITKWNNASDDWHTPRAENDLRAGGKFLCRMEAKDGSVGFDFAGVYDEVKKNELIAYTLGDERKVKVTFTKNNDVETKVVETFEAESTNPLEMQRGGWQAILDNFKKYVEASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNV5</accession>
    <name>A0A075MNV5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385059.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNV5"/>
    <dbReference type="STRING" id="1459636.NTE_00820"/>
    <dbReference type="GeneID" id="43502579"/>
    <dbReference type="KEGG" id="nev:NTE_00820"/>
    <dbReference type="HOGENOM" id="CLU_2985482_0_0_2"/>
    <dbReference type="OrthoDB" id="11286at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="57" mass="6526" checksum="5DE213BD031B231C" modified="2014-10-29" version="1">MVVQDRKYQKKKVAVEKFVKKNGTADHSAILNSIDVDYDTLMRILSELRNEGRISSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MP74</accession>
    <name>A0A075MP74_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01272</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MP74"/>
    <dbReference type="STRING" id="1459636.NTE_01272"/>
    <dbReference type="KEGG" id="nev:NTE_01272"/>
    <dbReference type="HOGENOM" id="CLU_1521798_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="176" mass="19677" checksum="513B1C15DE0ED711" modified="2014-10-29" version="1">MTYTKCHQNRCGKNARSATAGERCVLPAGARARFRRDGKSATTATGLEACYAPIAAEAAAGAKARGLKISYYFGCALWLSCQGCMPVPQGSLRYRAPRRSAVCILSVRSFLSGTWAGRRSWRHSRWRRRLTIFQRRGFWFGYAGHIIRVYVIPSQRIKISWGICPITSARLLVICI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MP90</accession>
    <name>A0A075MP90_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Signal recognition particle receptor FtsY</fullName>
            <shortName evidence="8">SRP receptor</shortName>
            <ecNumber evidence="8">3.6.5.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ftsY</name>
        <name evidence="11" type="ORF">NTE_01292</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.4"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the GTP-binding SRP family. FtsY subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.4" evidence="8"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700146.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MP90"/>
    <dbReference type="STRING" id="1459636.NTE_01292"/>
    <dbReference type="GeneID" id="41597095"/>
    <dbReference type="KEGG" id="nev:NTE_01292"/>
    <dbReference type="eggNOG" id="arCOG01227">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039705_0_0_2"/>
    <dbReference type="OrthoDB" id="372188at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005047">
        <property type="term" value="F:signal recognition particle binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000566">
        <property type="entry name" value="Signal recognition particle receptor subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="entry name" value="Signal recognition particle SRP54, nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00920">
        <property type="entry name" value="FtsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004390">
        <property type="entry name" value="SR_rcpt_FtsY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00064">
        <property type="entry name" value="ftsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134:SF1">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="Domain of the SRP/SRP receptor G-proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP54-type proteins GTP-binding" evidence="10">
        <location>
            <begin position="275"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="313"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="326"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="353"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="380"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="415"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="489"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="502"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="114"/>
            <end position="121"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="196"/>
            <end position="200"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="254"/>
            <end position="257"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIF83361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="511" mass="56664" checksum="9096C6D672C7232A" modified="2014-10-29" version="1">MFDKLKKALSGAAKSIGQKEINEKILDETLLDLQIELLESDVAQEVVDDLSARLKKDLLGLKLEKGQDASQVIESKLQEIVAGIFARAGRLDIVEKIRAKKEAKQGPFVIVFLGINGTGKTTTVAKVGNLLRKSGISVVVAAGDTHRAGAIEQLTQHAERLSLKVIAQRYGADPSAVGRDAVDYAKKHYIDAVLIDTAGRMQTSKNLMDEMSKIVRVVKPDIKLFVGDSLAGNDTINQAREFFQYANFDGAILTKIDADAKGGAAISIAHLTSKPIAYVGVGQGYDDMIPFDPDKFITSLFGSAAVSVQDLMSAAPLPPSPPATEPETRQEEVEPRPATAAVASGSPIFAPRAVEEEPITKDDHDRDLPPSPSPVQASSPPSPPPSPPSPPQSYVPEPAREEKKSRFGGLFGRKKSSDDGGNEEKRRREEEEDNRRRVEDLNRRKEEDEERQRRKEEEQRRKDEEQQRKREEEERKRKEKEEKKKKRKDDKDSSKDEVVYLTDEDIEDLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPE8</accession>
    <name>A0A075MPE8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00586</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPE8"/>
    <dbReference type="KEGG" id="nev:NTE_00586"/>
    <dbReference type="HOGENOM" id="CLU_2257226_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="103" mass="11635" checksum="BFA46024FE44F23B" modified="2014-10-29" version="1">MWWEAITRESRAIRVQEATVGKDRMHQREEKEEVQEATVVVVIIMKEIVAVETAREYRAEEATVVVVIIMKEIVAGADKIMKAAGNIATAYQSPTRLMARHAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPI5</accession>
    <name>A0A075MPI5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00975</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385088.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPI5"/>
    <dbReference type="STRING" id="1459636.NTE_00975"/>
    <dbReference type="GeneID" id="43502584"/>
    <dbReference type="KEGG" id="nev:NTE_00975"/>
    <dbReference type="HOGENOM" id="CLU_3130667_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="49" mass="6002" checksum="A6732F6E12EF05A6" modified="2014-10-29" version="1">MNEKIWPHNDQDYHSFSALLYNAIDSSWKVFALHWYGSDIHHRRKMARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPJ4</accession>
    <name>A0A075MPJ4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase with PP-loop ATPase domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_01417</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPJ4"/>
    <dbReference type="STRING" id="1459636.NTE_01417"/>
    <dbReference type="KEGG" id="nev:NTE_01417"/>
    <dbReference type="eggNOG" id="arCOG00038">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053822_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004810">
        <property type="term" value="F:CCA tRNA nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059101">
        <property type="entry name" value="NFACT-R_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020536">
        <property type="entry name" value="ThiI_AANH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11933:SF6">
        <property type="entry name" value="THIL AANH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11933">
        <property type="entry name" value="TRNA 5-METHYLAMINOMETHYL-2-THIOURIDYLATE -METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18297">
        <property type="entry name" value="NFACT-R_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02568">
        <property type="entry name" value="ThiI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thil AANH" evidence="3">
        <location>
            <begin position="43"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="NFACT protein RNA binding" evidence="4">
        <location>
            <begin position="271"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF83481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="377" mass="41368" checksum="7B0CB3B18BCE6B22" modified="2014-10-29" version="1">MSACESETGHTPFYNETDHIQLYIIMSQQDAQKKDDVETKKPKAVALLSGGLDSSLAVRMMLEQGVDVEAVAIKTPFCDFDCGKGCGHRVKEVADELGVKLKTVYFGEDYLRMLKKPKHGYGSGMNPCIDCREMMYGAAKEHMEKIGADFVVTGEVLFQRPMSQNNKALHIIENETGLEGKVLRPLSAKHLPPTDAEKEGLIKRENMGDIKGRSRKGQLALAKHFGVQEPPNAAGGCLLTDPAFSKRIEDAMEHADGDIPTINDIELLKVGRHFRLTPAEKLVVGRNKDENEVIKALVVDDTDIVLEAKDHVGPTCILRGKTHDEATIARAAAIVLRYSDAPKDAASKVKVTMADKKEERELEAVPAGVPETDALRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPM5</accession>
    <name>A0A075MPM5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00702</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699684.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPM5"/>
    <dbReference type="GeneID" id="41596557"/>
    <dbReference type="KEGG" id="nev:NTE_00702"/>
    <dbReference type="eggNOG" id="arCOG08777">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG08800">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_270603_0_0_2"/>
    <dbReference type="OrthoDB" id="12300at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="1181" mass="121706" checksum="1D3DA3B5DC2B050D" modified="2014-10-29" version="1">MDYSYGKKKYAGTALAALIIFGAVTAALVVVPHAAYAATSITTSADKFYGPNLLRVVITDTAKNTATDTALVHVDFNHLGSPLGSADYTIKNIGTSGTFEFFITTSNTLNPTAPTFTGTGGAFVLRANTVPTTVNTNDQGVTLASQLQDQDSIVITYGDLPQKTVSFAKSNAVANVDRNTAGSGDNVVLTLVDSDANIDPTKADIFNATNLVSASTGTLTLSGAKFRETGQNTGQFELTVAVAGPAPLNGASLTATFPSSTTLTINDKDVYVAGNGPAPFDVVGPNPSTITSSKSVTLQNVDGVLTTLKPITLGNGIMLQVTDSDRNVDTKSKDTIGVGNVTVQVDGVTMPSPMVNAIPLQETASGSGIFVPNTTDNKISIKVGPTDNVTTTSIQLTPATIASDPDITITYNDPAADPSGAKAFKLITKLTHSAGTLAGPTQAGVTDKFGLTITDPDLNTNSKSVDSFIVTFPVSPANTANGVSFANGMGTMTLKAKGSGLTLGSALTMTFIETDIDSGIFTASNIDMSIINAAVSGGLSDGDQIEFKYTDNTESPTQSSTITFNIGKPTASISINRGTIPIPTAGTGSKFTVTIVDSTKNVNSNSVDTFSTGVTIAGTKKDGSSNLDTTIMTGLGAGKTFTETGANTGVFTADYTVGSGTQIAANMDSAKIKFTYTTGGTTTSASVTLRSYDGTVLSNVSSVQNGGNITITVNDPDMNKDSGTAEQVSVTIQGKSDDIGSAITLSDLKETGSDTGVFTKTITVGKDFKISDLTNNKFSTAFEIHYVDLLASDLSTSVDREFDGTVKTSSGTIGITPTIVGPGTKIFIEVKDPDLNANPAGIDTTASGVEYIRITSDRSGANTLTTALGEETGSNTGIFRTKLTLNPITGATPSPLFPPNTTKEVTGFVLPGDILSIRYTDQKDASGSKATVSQVIKVISQDPVMNSSKVTIDANGSVQVTVTDADANTDGDAVDSITLKVTSTTDPVGISVTALETGANTGVFRGTVTTTTGVTTGSVSAKVGDNVNVKYTDKYPADYADRVKQVVDPSKDFTFVIPVGTSSGSGNVDATSAAKPVLKDFSGNELTEVTAGQQIVLSSTVTNNQNTVQPFAAIVEVRDANGFTVYLQWQTGSLNPNGSTNVGLSWTPDVSGTYTARTFVVTDIAHPSALSQISESTITVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPP3</accession>
    <name>A0A075MPP3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Uridylate kinase</fullName>
            <shortName evidence="11">UK</shortName>
            <ecNumber evidence="11">2.7.4.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Uridine monophosphate kinase</fullName>
            <shortName evidence="11">UMP kinase</shortName>
            <shortName evidence="11">UMPK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">pyrH</name>
        <name evidence="13" type="ORF">NTE_01026</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the reversible phosphorylation of UMP to UDP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>UMP + ATP = UDP + ADP</text>
            <dbReference type="Rhea" id="RHEA:24400"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.22"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="11">Inhibited by UTP.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; UDP from UMP (UMPK route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the UMP kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.22" evidence="11"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699930.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPP3"/>
    <dbReference type="STRING" id="1459636.NTE_01026"/>
    <dbReference type="GeneID" id="41596849"/>
    <dbReference type="KEGG" id="nev:NTE_01026"/>
    <dbReference type="eggNOG" id="arCOG00858">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079546_0_0_2"/>
    <dbReference type="OrthoDB" id="372251at2157"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033862">
        <property type="term" value="F:UMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006225">
        <property type="term" value="P:UDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01220_A">
        <property type="entry name" value="PyrH_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011817">
        <property type="entry name" value="Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011818">
        <property type="entry name" value="Uridylate_kinase_arch/spir"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02076">
        <property type="entry name" value="pyrH_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42833">
        <property type="entry name" value="URIDYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42833:SF4">
        <property type="entry name" value="URIDYLATE KINASE PUMPKIN, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005650">
        <property type="entry name" value="Uridylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aspartate/glutamate/uridylate kinase" evidence="12">
        <location>
            <begin position="9"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="13"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="121"/>
            <end position="127"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIF83100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="234" mass="24688" checksum="74D11533944DE7DD" modified="2014-10-29" version="1">MVVLDKSRRVVIKLSGKVFSGEDGSEIKRYASMLANLSSSAKVQPVVVAGGGRVARHYINIARGFGLDEASLDIMGIEVSRLNAKLLIAALGEKAYPAVPEDLEQVTEAAASGKIVVAGGLHPGQSTNATSALIAEKVGAARFVNATDVDGIYDSDPRKNKGARHYSEITTKQCRDLLSGESSMAGGYDLMDIVALKVIERSKIPTVVIKSEPEVIRDVVLKNKAAGTKIIVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPT4</accession>
    <name>A0A075MPT4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01508</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700319.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPT4"/>
    <dbReference type="GeneID" id="41597297"/>
    <dbReference type="KEGG" id="nev:NTE_01508"/>
    <dbReference type="eggNOG" id="arCOG08764">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1590793_0_0_2"/>
    <dbReference type="OrthoDB" id="10509at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="184" mass="19375" checksum="1FF8D04EAEC48301" modified="2014-10-29" version="1">MSASNNNSKKKTKFSILAIAIVAAVAIAIALQAGYASAQQQGSNSTIVRVQKTVMSAPAPVTAQGHPTHQVVFALPLRDDGRIWSGTVTFTASKPIEIEVMHRYNPAVAPTAEYGQPPVAVINGTTITYSHMTGIVDTPILSGDSPISSGTFDFTGSALVFHKRSGEPFTVTYTIDAVAKTLTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQ89</accession>
    <name>A0A075MQ89_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zn-dependent alcohol dehydrogenase</fullName>
            <ecNumber evidence="9">1.1.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NTE_01162</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.1" evidence="9"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700032.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQ89"/>
    <dbReference type="STRING" id="1459636.NTE_01162"/>
    <dbReference type="GeneID" id="41596974"/>
    <dbReference type="KEGG" id="nev:NTE_01162"/>
    <dbReference type="eggNOG" id="arCOG01455">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_20_1_2"/>
    <dbReference type="OrthoDB" id="8709at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08296">
        <property type="entry name" value="CAD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000039">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF7">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE-LIKE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="8">
        <location>
            <begin position="11"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF83235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="344" mass="36346" checksum="3C9FC9B9CA55748A" modified="2014-10-29" version="1">MRSVQVSKPQGALEVVERNNIPEPGSAQVRIKVQACGICHSDYLTKDGLYPGIQYPRVPGHEIAGIIDAVGKDVNEWKSGQRVGVGWHGGHCGHCDSCRRGDFTTCSYLQIPGISYDGGYADYMIAPKEAVASIPDELSPTEAAPLMCAGITTYNALRNSGARPGDVVAILGIGGLGHLAIQFSNKMGFKTIAIGRGKDKAERVRKLGAIHYIDTNSVNAAEELQKYGGSGDGGSGAKVILATVPSAKAMNSVLGGLAVNGKLVVIGHSDEPIEVPTDLLLLGRRSLVGWASGTATDSQDTLSFSVLSGVRPMTEVYPLERAAEAYQQMISGKARFRAVLTTEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQ92</accession>
    <name>A0A075MQ92_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lactoylglutathione lyase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700143.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQ92"/>
    <dbReference type="STRING" id="1459636.NTE_01289"/>
    <dbReference type="GeneID" id="41597092"/>
    <dbReference type="KEGG" id="nev:NTE_01289"/>
    <dbReference type="eggNOG" id="arCOG04946">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_127592_3_0_2"/>
    <dbReference type="OrthoDB" id="134577at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07247">
        <property type="entry name" value="SgaA_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052164">
        <property type="entry name" value="Anthracycline_SecMetBiosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053863">
        <property type="entry name" value="Glyoxy/Ble-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33993">
        <property type="entry name" value="GLYOXALASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33993:SF2">
        <property type="entry name" value="VOC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22677">
        <property type="entry name" value="Ble-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyoxalase/Bleomycin resistance-like N-terminal" evidence="1">
        <location>
            <begin position="4"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="127" mass="14319" checksum="07838F52BE057160" modified="2014-10-29" version="1">MASIVHFEIPADNIERAKKFYDGLFGWKAERTQGASMEGGPIEYWTFRTGDENEGQQPISGGIMNRMYPKHSITNYIGVDSAIEYSKKVERLGGKVMVPKTEVPGLGWLAICMDTENNIFALWEAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQG0</accession>
    <name>A0A075MQG0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chlorite dismutase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_01245</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700104.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQG0"/>
    <dbReference type="STRING" id="1459636.NTE_01245"/>
    <dbReference type="GeneID" id="41597051"/>
    <dbReference type="KEGG" id="nev:NTE_01245"/>
    <dbReference type="eggNOG" id="arCOG03031">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076582_0_0_2"/>
    <dbReference type="OrthoDB" id="8690at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1030">
        <property type="entry name" value="Apc35880, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010644">
        <property type="entry name" value="ChdC/CLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36843:SF1">
        <property type="entry name" value="COPROHEME DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36843">
        <property type="entry name" value="HEME-DEPENDENT PEROXIDASE YWFI-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06778">
        <property type="entry name" value="Chlor_dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF83315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="240" mass="27958" checksum="F91BDA3744694405" modified="2014-10-29" version="1">MSAEKPSSSLQPSQEQQQQPTTYYLNFTFLKVDPKWRWLNEIGKDEAAKEFASLIEVANTKMKVRTYSTVGLREDADMMVWMISDSIEKTQILASKIYTTVFGKYVTPSYVFLSSSRPSVYSSKVTPGFMTDEQPLKYVVVYPFVKSREWYLLPFEERKKMMEEHIAVGRKFPQVRLNTTYSFGIDDQDFMLAFETQDLPAFQELIMQLRETQVSRYIVRDTPMIVCVHKKPEDILKSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQH4</accession>
    <name>A0A075MQH4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetrahydromethanopterin S-methyltransferase, subunit A</fullName>
            <ecNumber evidence="2">2.1.1.86</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.86" evidence="2"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700489.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQH4"/>
    <dbReference type="STRING" id="1459636.NTE_01720"/>
    <dbReference type="GeneID" id="41597489"/>
    <dbReference type="KEGG" id="nev:NTE_01720"/>
    <dbReference type="eggNOG" id="arCOG03220">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1674043_0_0_2"/>
    <dbReference type="OrthoDB" id="130682at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030688">
        <property type="entry name" value="MeTrfase_MtrA/MtxA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04208">
        <property type="entry name" value="MtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="159" mass="17093" checksum="7C38DFE3C5E73DA8" modified="2014-10-29" version="1">MTFKKKFDDAAGKVCEALIPVKHESFEGEGKEVAVCTLGSIDLLEKISESETIMGKVAIAGRLLSENKGIDAIIDYVSAHPDLKRIIVCGREVKGHMAGQALLALYKNGIDGQGRIIGAAGPYPVLLSSQEKVEVFRRQVTITDMIGVIALEKITLLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQH6</accession>
    <name>A0A075MQH6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Zinc-ribbon domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01054</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699952.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQH6"/>
    <dbReference type="STRING" id="1459636.NTE_01054"/>
    <dbReference type="GeneID" id="41596876"/>
    <dbReference type="KEGG" id="nev:NTE_01054"/>
    <dbReference type="eggNOG" id="arCOG08023">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1154315_0_0_2"/>
    <dbReference type="OrthoDB" id="9907at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026870">
        <property type="entry name" value="Zinc_ribbon_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13240">
        <property type="entry name" value="Zn_Ribbon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zinc-ribbon" evidence="1">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="240" mass="25181" checksum="B570AF702E84BE8F" modified="2014-10-29" version="1">MMTEDMAEKKLRGSGGYAIAKVSDEEQKMANLGGPELFLAGIGRLDTGRFVKYFCNKCERDFEGAPTLSYDNPNEDLGEGVTLVEKGEYKCRACNATIAQYRKFNAPAQTPQVAPKAEAAPAPESAITPVPAAVISPTQDGGFVSISQLVGMAAYDGEAMLVGKIEEVGLRKQGGRATISVKIVSSAGDKKEVQWDGISKIGDIVLLKAGGAPATAGKCPSCGYQNEAGAAFCEECGTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQJ0</accession>
    <name>A0A075MQJ0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01064</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQJ0"/>
    <dbReference type="KEGG" id="nev:NTE_01064"/>
    <dbReference type="eggNOG" id="arCOG03067">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124803_5_1_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="123" mass="13928" checksum="65C9097D95811BF0" modified="2014-10-29" version="1">MNALTFDSHTTAMPLLQELVDCISYRLIMSTIDTAKTAAQVSVENNLPLSSTYKKIKKLQDVGILFIEKIELDGKGKKVVYYRSRIKSMEFNLSRDQILLQFEKNDVHLSSAQVNVIKQSAAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQS2</accession>
    <name>A0A075MQS2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC-type sugar transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_01495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700307.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQS2"/>
    <dbReference type="STRING" id="1459636.NTE_01495"/>
    <dbReference type="GeneID" id="41597284"/>
    <dbReference type="KEGG" id="nev:NTE_01495"/>
    <dbReference type="eggNOG" id="arCOG00151">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_408622_0_0_2"/>
    <dbReference type="OrthoDB" id="30637at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050490">
        <property type="entry name" value="Bact_solute-bd_prot1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43649">
        <property type="entry name" value="ARABINOSE-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43649:SF12">
        <property type="entry name" value="DIACETYLCHITOBIOSE BINDING PROTEIN DASA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF83558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="672" mass="74358" checksum="172360C225906253" modified="2014-10-29" version="1">MNSLEHSIFRIITVGIILFNIVVIGASSALAAAAGNNNNNNSSSSAGVIGTSTRGEKERDYYVNATAEQRHKEHLAMGAAITEPYTANLNYTLVAVGSASQGQVKSSLREDARITLNLSVWKSTKAVVSMDIMNGTVKIGNNKELQVHSGHAYYLINSHLMRIIGYIIIARESAGSEHQPSSSQVQTLKLIGKATTADDARLPAGTGSNQQPPLKIQILAAQSKLAPGWSLDMNAEVRLERGDSSSLPPQTTGQEGQKAAAQKKQVTLTAILDNLGDEERFHALIDSALQKLRERHPDLDIQVVEKQFAYPEERNQLIKSVANGTEVDLMSVDQIWLGELAEKGLLTDLGNYTKSWGRALDWYQSNWDGGAYKGKTYGIWVWTDVRGMYYWKDLLEAASVDPDSLKTWDGYIESAKKLDASLRPKGIEGVHLTGASHSPDLWYPYLWMLGGDILEQKSGHPTKGVYWFPAYNSSKGVEALTFLKHQVDAGIVPQKSHFWGKEFADKKFAVMIEASHVPGEFSPDQKQDLDKKVGFIPMLPVPNQNTQTTTLMGGWELSIPVTSRHKELAWELISLMVEPEILAPWLAKYNYLPTQLPIGEGPYSQQLRQTNPFFDDMVSMIQHGRSRPSIPEYPQIAEHIREAIDDVYYGKKEPKQALDDAAAKSAQALGWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQS9</accession>
    <name>A0A075MQS9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Malic enzyme</fullName>
            <ecNumber evidence="8">1.1.1.38</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NTE_01500</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the malic enzymes family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.38" evidence="8"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987218.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQS9"/>
    <dbReference type="STRING" id="1459636.NTE_01500"/>
    <dbReference type="GeneID" id="41597288"/>
    <dbReference type="KEGG" id="nev:NTE_01500"/>
    <dbReference type="eggNOG" id="arCOG00853">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034446_2_1_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004470">
        <property type="term" value="F:malic enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05311">
        <property type="entry name" value="NAD_bind_2_malic_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="entry name" value="Malic enzyme, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051674">
        <property type="entry name" value="Malate_Decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015884">
        <property type="entry name" value="Malic_enzyme_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045213">
        <property type="entry name" value="Malic_NAD-bd_bact_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43237">
        <property type="entry name" value="NADP-DEPENDENT MALIC ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43237:SF4">
        <property type="entry name" value="NADP-DEPENDENT MALIC ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000106">
        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00331">
        <property type="entry name" value="MALIC_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Malic enzyme N-terminal" evidence="7">
        <location>
            <begin position="15"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Malic enzyme NAD-binding" evidence="6">
        <location>
            <begin position="165"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF83563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="412" mass="44604" checksum="196A316024EBA500" modified="2014-10-29" version="1">MGLKEDAINLHRMLRGKIEIHNRVSVDSIFEEEKGTLGLIYTPGVAYVSREISGNKELAYEYTSKWNNVAIICDGTRVLGLGNVGPEAAIPVMEGKSVLFKSLADINAIPLCIATQDKQEIIRIAKAIQPGFGAVNIEDIESPKVLEIVEALKEELDIPVFHDDQHGTAVITLAALVNALDLTGKKMDRIKVIIAGAGSAGYGIYRILEQAGCRDIIVADSKGAIYEGRADIVSSSNDEGSKNKYRQEIAKRTNADKVSGSIKEVIKGADLFIGVSGRGNIVSRDMVRTMNKDAIVFALSNPDPEVLPPDALAAGARIAATGRSDFANQINNAVVFPSVLRALLDLHARYLDEDMLVAVAFAIASLVDRKHLTESFIIPKVNDPRILPVVTQTLRDAVMKHIDAKGQVMSQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQT5</accession>
    <name>A0A075MQT5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Large ribosomal subunit protein eL32</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpl32e</name>
        <name evidence="6" type="ORF">NTE_01388</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the eukaryotic ribosomal protein eL32 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700225.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQT5"/>
    <dbReference type="STRING" id="1459636.NTE_01388"/>
    <dbReference type="GeneID" id="41597184"/>
    <dbReference type="KEGG" id="nev:NTE_01388"/>
    <dbReference type="eggNOG" id="arCOG00781">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071479_3_1_2"/>
    <dbReference type="OrthoDB" id="372100at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00513">
        <property type="entry name" value="Ribosomal_L32_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00810">
        <property type="entry name" value="Ribosomal_eL32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001515">
        <property type="entry name" value="Ribosomal_eL32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023654">
        <property type="entry name" value="Ribosomal_eL32_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018263">
        <property type="entry name" value="Ribosomal_eL32_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036351">
        <property type="entry name" value="Ribosomal_eL32_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006332">
        <property type="entry name" value="PRK08562.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23413">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L32 AND DNA-DIRECTED RNA POLYMERASE II, SUBUNIT N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23413:SF1">
        <property type="entry name" value="RIBOSOMAL PROTEIN L32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01655">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01393">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52042">
        <property type="entry name" value="Ribosomal protein L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00580">
        <property type="entry name" value="RIBOSOMAL_L32E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF83455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="144" mass="16071" checksum="6BC102C8F7D4F103" modified="2014-10-29" version="1">MVINGELLAARKKVASKRPKFVRQESWRYDRLAENWRKPKGKDNKMRKQKGGYPALVKVGYRGPKAARGLHPSGYTDNIVYNVADLSGLDAKKDAVRLAHTVGTRKRKEIIEQAAKAGFKILNAGKLAPKKEEGEAVETGEEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MR19</accession>
    <name>A0A075MR19_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700056.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MR19"/>
    <dbReference type="GeneID" id="41597000"/>
    <dbReference type="KEGG" id="nev:NTE_01190"/>
    <dbReference type="HOGENOM" id="CLU_2177963_0_0_2"/>
    <dbReference type="OrthoDB" id="11600at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="110" mass="11023" checksum="F249A172EAF6A22E" modified="2014-10-29" version="1">MSLFAGASKIAAVVAAGYIIAFFVLASGGLNAATEGSKVAAFIVPSRSVQTPGETGAITLILVIGLAGMFMLHRAGKSAGARAQRIMLAGGFGVVAVALMIGYLLVNVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRS5</accession>
    <name>A0A075MRS5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase</fullName>
            <ecNumber evidence="3">2.4.1.227</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_00030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 28 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.227" evidence="3"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699182.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRS5"/>
    <dbReference type="STRING" id="1459636.NTE_00030"/>
    <dbReference type="GeneID" id="41595982"/>
    <dbReference type="KEGG" id="nev:NTE_00030"/>
    <dbReference type="eggNOG" id="arCOG01393">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_945330_0_0_2"/>
    <dbReference type="OrthoDB" id="46222at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21015:SF22">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21015">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--N-ACETYLMURAMYL-(PENTAPEPTIDE) PYROPHOSPHORYL-UNDECAPRENOL N-ACETYLGLUCOSAMINE TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase family 28 C-terminal" evidence="2">
        <location>
            <begin position="195"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF82114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="340" mass="37819" checksum="AB75D6F24B013685" modified="2014-10-29" version="1">MLLFFASPIGLGHATRDIAIAEKLQGYDIFFVSGEGASRLIEKKGYTVVDAYRPEKFIVQDGQLQQSFRWLMSYYSYYKKCKEVAKGVLAEHDDNPIVSDEDFASIAVAEEARRKRVLITDIAETHFTKGAASLIEKKMNGAMKDMMKKCDCVIIPDDGDDYDNISYVGPIVRKATADRETLRKRLGFSRKTIVVSIGGTDAGRYLIERSLDAYRKLRDKLDADLVVVPGPSLQLPESPDYRNLGFIDNLHELIYAADLVVSLAGRSTMDESIAYGTPGIFIPIKGHFEQEQGAARLGYKHEDVFRLESLIEEKIGSRRNNTVNTGGAEKAAKIISTLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRV6</accession>
    <name>A0A075MRV6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01489</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRV6"/>
    <dbReference type="STRING" id="1459636.NTE_01489"/>
    <dbReference type="KEGG" id="nev:NTE_01489"/>
    <dbReference type="HOGENOM" id="CLU_3282669_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="40" mass="4501" checksum="382B80A023D3F12B" modified="2014-10-29" version="1">MRCGTYDNTMYAGVPSFSIEVADYIPQYLCIGEGREESSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRX3</accession>
    <name>A0A075MRX3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01504</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700314.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRX3"/>
    <dbReference type="GeneID" id="41597292"/>
    <dbReference type="KEGG" id="nev:NTE_01504"/>
    <dbReference type="HOGENOM" id="CLU_186515_0_0_2"/>
    <dbReference type="OrthoDB" id="379314at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="92" mass="10055" checksum="A018015C487FB97E" modified="2014-10-29" version="1">MLLKKAKAINKPSYNRMQRERKEMKAKLVALGGGIIAAGVLLFLYVSLQPTTPDCLDNCGLTSGGDLYLTSMLPIVIFTLGGWMLALGIRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRX6</accession>
    <name>A0A075MRX6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01789</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226986914.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRX6"/>
    <dbReference type="STRING" id="1459636.NTE_01789"/>
    <dbReference type="GeneID" id="41597555"/>
    <dbReference type="KEGG" id="nev:NTE_01789"/>
    <dbReference type="eggNOG" id="arCOG08722">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_170814_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="111" mass="12889" checksum="41F7B2856560CDDD" modified="2014-10-29" version="1">MPAREFAFRIKLSSEEQERELASYLSSLSADDVLFGLRFAYNRYTAASGGYLMPGRKSMVKRETHLLSADQAKWRLNNWKTMIRTYRDKGYSYPTISRIKKQLQKIAAGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRZ5</accession>
    <name>A0A075MRZ5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02227</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_264357902.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRZ5"/>
    <dbReference type="STRING" id="1459636.NTE_02227"/>
    <dbReference type="GeneID" id="75933627"/>
    <dbReference type="KEGG" id="nev:NTE_02227"/>
    <dbReference type="HOGENOM" id="CLU_3282989_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="41" mass="4746" checksum="DFCD1EA449407005" modified="2014-10-29" version="1">MPSKKEVPLAPRLVVSKRAKTAEDLENEEYLRQLELAIENH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRZ7</accession>
    <name>A0A075MRZ7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor E</fullName>
            <shortName evidence="4">TFE</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">TFIIE subunit alpha homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Transcription initiation factor TFIIE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">tfe</name>
        <name evidence="7" type="ORF">NTE_00095</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer. Interaction with RNA polymerase subunits RpoF and RpoE is necessary for Tfe stimulatory transcription activity. Able to interact with Tbp and RNA polymerase in the absence of DNA promoter. Interacts both with the preinitiation and elongation complexes.</text>
    </comment>
    <comment type="domain">
        <text evidence="4">The winged helix domain is involved in binding to DNA in the preinitiation complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TFE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRZ7"/>
    <dbReference type="STRING" id="1459636.NTE_00095"/>
    <dbReference type="KEGG" id="nev:NTE_00095"/>
    <dbReference type="eggNOG" id="arCOG04270">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100097_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01909">
        <property type="entry name" value="TFE_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016481">
        <property type="entry name" value="TF_E_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039997">
        <property type="entry name" value="TFE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017919">
        <property type="entry name" value="TFIIE/TFIIEa_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002853">
        <property type="entry name" value="TFIIE_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024550">
        <property type="entry name" value="TFIIEa/SarR/Rpc3_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13097:SF7">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13097">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIE, ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02002">
        <property type="entry name" value="TFIIE_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00531">
        <property type="entry name" value="TFIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51344">
        <property type="entry name" value="HTH_TFE_IIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH TFE/IIEalpha-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="180"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="188"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF82179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="242" mass="26947" checksum="3BA329B4DFBB6E8F" modified="2014-10-29" version="1">MHAMDYEDSFVKIAGLIGGEEYVKVSRALLNTEDVTDEEIASATGLKINIVRKVLYDLFGKALITGIRVKDEKKGWFVYRWRAKQDHVDNFIENQKKKILDRLHKRLEHEDSTEFYHCGNHDCPRVKFDTAVELFFKCPNCKGPLNMVDNSKVKEALRYKIDQITTDIINSKANAAANKEAAEAAAAAEEEEEEGEEEEAGEKAAKGKKSSKKPSSSSSKAKAPANSSKKAAAAAPKPKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MS47</accession>
    <name>A0A075MS47_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MS47"/>
    <dbReference type="KEGG" id="nev:NTE_01875"/>
    <dbReference type="HOGENOM" id="CLU_2730141_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="71" mass="7867" checksum="B94BCAD3405EC80E" modified="2014-10-29" version="1">MALVEQQRNKISLLVCNSCYWMSSLLDSSKEVPNCPSCGTTLESLPVENNERCTIEAADTKTGLIVEFQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MS62</accession>
    <name>A0A075MS62_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Homocitrate synthase</fullName>
            <ecNumber evidence="4">2.3.3.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_01584</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alpha-IPM synthase/homocitrate synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.13" evidence="4"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700379.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MS62"/>
    <dbReference type="STRING" id="1459636.NTE_01584"/>
    <dbReference type="GeneID" id="41597364"/>
    <dbReference type="KEGG" id="nev:NTE_01584"/>
    <dbReference type="eggNOG" id="arCOG02092">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022158_4_2_2"/>
    <dbReference type="OrthoDB" id="6555at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054691">
        <property type="entry name" value="LeuA/HCS_post-cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42880">
        <property type="entry name" value="HOMOCITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42880:SF1">
        <property type="entry name" value="ISOPROPYLMALATE_HOMOCITRATE_CITRAMALATE SYNTHASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22617">
        <property type="entry name" value="HCS_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="3">
        <location>
            <begin position="30"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF83647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="408" mass="45010" checksum="56E2D29BBE398A5D" modified="2014-10-29" version="1">MSLKSDDPNYYAHMYNRMGGPDAATSGRRIRILDSTLREGEQHPGVNFTTKQRIQIAWMLDSFGVDQIEISPVVSPDHVEATKTIIKQGLRADIVAHVRAIKSDVDIAIGCGATWVATYMGISDIHLAAKLKISREEAKTRALEVADYIKSHGLKSRFTMEDASRTEPEFLIDMCKEMNRRGIERISIPDTVGIMRPRGMFSLVKMVYDNIDRSKTSLDVHCHNDVGLALANALAGCEAGADQIHTTIDGFGERTGIPALAETAVALSLIYKANSDLRLHMTKDLSRTMSEYVDLGIPESKPIVGDSAYKHKAGTHLAAILRNPAAYEILEPKAVGNRRKIVFGELAGKNGAAYLLSLLGLETSKHEAEQLAKGLKELRMGDILELYLDDRLERKILNDAPMKVGQKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSL0</accession>
    <name>A0A075MSL0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkylhydroperoxidase AhpD family core domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00252</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699338.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSL0"/>
    <dbReference type="STRING" id="1459636.NTE_00252"/>
    <dbReference type="GeneID" id="41596164"/>
    <dbReference type="KEGG" id="nev:NTE_00252"/>
    <dbReference type="eggNOG" id="arCOG02148">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126621_0_0_2"/>
    <dbReference type="OrthoDB" id="111898at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004675">
        <property type="entry name" value="AhpD_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00778">
        <property type="entry name" value="ahpD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxymuconolactone decarboxylase-like" evidence="1">
        <location>
            <begin position="36"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="135" mass="15372" checksum="EC633CEA4C30D5D4" modified="2014-10-29" version="1">MTEMVSYEQTRREIQKTFGSIPGFMAAVPQDVLVQMWPIMKTYMMGQTKIPPKYREMISLAVGATLKCPYCEMFHRASAKMSGATDEELAEVGVLVGQVTFWSSILHTLNYDMSTFMKEFNAMGEYLSKQSRQTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSM3</accession>
    <name>A0A075MSM3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase SSV1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02528</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701124.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSM3"/>
    <dbReference type="GeneID" id="41598230"/>
    <dbReference type="KEGG" id="nev:NTE_02528"/>
    <dbReference type="eggNOG" id="arCOG01247">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1010487_0_0_2"/>
    <dbReference type="OrthoDB" id="12173at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031857">
        <property type="entry name" value="Integrase_SSV1_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16795">
        <property type="entry name" value="Phage_integr_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase SSV1 C-terminal" evidence="1">
        <location>
            <begin position="116"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="275" mass="32515" checksum="F00A8F8E3021C5CC" modified="2014-10-29" version="1">MQPDWNGFRQYLNNIQNPKVANDTLRYARQHYRILWGEGMEELLQLSQGKQRHVMKAMSSLSKYLGCYNHWKEIREGYQLKWSQQDSLELFHNIIDNEHNYSAMIEWLKEACAKSPKSYADILIYATLTGLRAQEVIDSIRLIKTTPENYLKKDSMILEHYRYPNLFIRRTKKAYVSIVSEDILQLAKTAGNHSYMAIRMALEERGMATNMKYCRKIFSTYLRMNGIESELIDLLQGRIPKTVFARHYFRPDFEKDMVRIRNVLEKLKGEITLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSW8</accession>
    <name>A0A075MSW8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative RNA-binding protein of the translin family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02633</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSW8"/>
    <dbReference type="STRING" id="1459636.NTE_02633"/>
    <dbReference type="KEGG" id="nev:NTE_02633"/>
    <dbReference type="eggNOG" id="arCOG04318">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099315_0_0_2"/>
    <dbReference type="OrthoDB" id="26985at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14820">
        <property type="entry name" value="TRAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002848">
        <property type="entry name" value="Translin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036081">
        <property type="entry name" value="Translin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10741">
        <property type="entry name" value="TRANSLIN AND TRANSLIN ASSOCIATED PROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01997">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74784">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR602848-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="217" mass="23995" checksum="D4C859896FFE9FF2" modified="2014-10-29" version="1">MPVVVTSSIQGSLEAIDKDLKDVQERREKLIKGTRDAVTLCSKSIIAMHHGQLGEAAEMMGQAKAMLVEFRVHAGDDLYRYIAVAEQELVEAYVLRAVMEGSSQLPSMADLEVSGPSYLTGLLDCVGEIKRLVYDRMRSGNEKDAESLFAVMEDIYGAVYPFAVYDNIVAGLRKKLDVARMLIEDIRAVVTEEKRRKAMVDAIDGLEKRLPGGRGNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MT08</accession>
    <name>A0A075MT08_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02184</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MT08"/>
    <dbReference type="KEGG" id="nev:NTE_02184"/>
    <dbReference type="HOGENOM" id="CLU_2949091_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="31"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="59" mass="6821" checksum="0714F94157E3529A" modified="2014-10-29" version="1">MHIPLPQSNLVNIIRTIFLAKMKFPSFGKKFKCTVCGDKFKTEAELEDHRVKMHATSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MT69</accession>
    <name>A0A075MT69_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH dehydrogenase, FAD-containing subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00432</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699471.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MT69"/>
    <dbReference type="STRING" id="1459636.NTE_00432"/>
    <dbReference type="GeneID" id="41596310"/>
    <dbReference type="KEGG" id="nev:NTE_00432"/>
    <dbReference type="eggNOG" id="arCOG01064">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030742_5_1_2"/>
    <dbReference type="OrthoDB" id="38899at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052541">
        <property type="entry name" value="SQRD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43755">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43755:SF1">
        <property type="entry name" value="FAD-DEPENDENT PYRIDINE NUCLEOTIDE-DISULPHIDE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="1">
        <location>
            <begin position="9"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="393" mass="42804" checksum="30E3665B61F1B501" modified="2014-10-29" version="1">MGKQKVTTTIVILGAGFGGLACANALRKGLSRDHRVIVIDRKKSFMMGLVNLWILTGSRKPDEPQAPLAGLNARGMEYLNDEAIRIDVSAKRVQAKEHGLIEYDYLVVALGSELVPEKIEGFVGRGYNLYDAEQVQPLREKLLALKQGRVAVSVMGMPYKCPPAPYEAAMIISDILEKNGTRKNVQVDMYVPAPIALPVVGPQVSKEVVDMMARYNIGFHPNCKPKVVRDDEIEFESGEKAAYDVLAGVPPHRSPEVVRISSLTTSSAAGEWVPVDRLSLRTGHPGVFAIGDVAEVKSGTVTVPKAGIFAEGQAKVVAQEIIDEINNNGAPASSAAYNGQGFCFMEVGNNMAGFVEADFYHEGGPAVRLEPPSAQNYEKKHDFERSRLKEWLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTD0</accession>
    <name>A0A075MTD0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00483</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTD0"/>
    <dbReference type="STRING" id="1459636.NTE_00483"/>
    <dbReference type="KEGG" id="nev:NTE_00483"/>
    <dbReference type="eggNOG" id="arCOG00371">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_477872_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="137"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="390"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="570" mass="63074" checksum="AB80F1D9BDD1CC4A" modified="2014-10-29" version="1">MIKKATRFFLYSMVKKFSPEQDNLIRSQWYQGLPRPEIERQADASAGHISDIVAEEKRLVGEGNVDTLRRLAIEVGKKGHTPVDIMRAIRFLNACNGLGMDDEKVIGCLPRVDEACKRGGIGIEGLPVDIESRLAKARELDARIQESERIAAEAEKHREEALRRAGQTDESLAKCQETRDFLASHGLVADSPERLKNALLNAEEANYDMEAIVAGISENESLRRGNASLATENAEIERRKAENAKVVGQQKSEMARNAEVLGKLHELERKGLGLPELTVIATTVSDVAVKNGMDGSTAVKKFIDDLKSTDYDRKAGFAVKADRLQKLCEEREAMHDQLKMEYAADKQAIQSLRVLYSRGVKNHEVVALKNIVVKSGASTTAELEDDITMYGTIKNANKEHEKRNKEVQTENLALEKRNELLKRENEALKKAGEEFRASFKKDTEEMTGTVKASREVLESATAGATQTVQKAVTDMEEKVKTFGTKIEGLSDTATRETDKIKKNQSLLRYDVLVRAEQGEPVSKAAAIASLVLAILAVRPMLTGVWLGDAGDHLDIVVDKMKYALKSGMIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTE0</accession>
    <name>A0A075MTE0_9ARCH</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02816</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
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            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_264357913.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTE0"/>
    <dbReference type="GeneID" id="75933634"/>
    <dbReference type="KEGG" id="nev:NTE_02816"/>
    <dbReference type="HOGENOM" id="CLU_3227636_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="43" mass="4911" checksum="13D8ADABE0CA124F" modified="2014-10-29" version="1">MTKEFCHLCKDGGKECVEIDESREVAMMKIHPRCSVCGRLLVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTH7</accession>
    <name>A0A075MTH7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00518</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987120.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTH7"/>
    <dbReference type="GeneID" id="68225752"/>
    <dbReference type="KEGG" id="nev:NTE_00518"/>
    <dbReference type="HOGENOM" id="CLU_3056946_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="53" mass="5868" checksum="8DA89BA6461309A0" modified="2014-10-29" version="1">MQAGDVSIVRTIAWIRIRGSKASMCLAATILYVLYRESGNATNQRNILDTEPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTJ7</accession>
    <name>A0A075MTJ7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02381</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTJ7"/>
    <dbReference type="STRING" id="1459636.NTE_02381"/>
    <dbReference type="KEGG" id="nev:NTE_02381"/>
    <dbReference type="HOGENOM" id="CLU_1507321_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="178" mass="19402" checksum="CDDF304A356B1BD2" modified="2014-10-29" version="1">MLQRSLKLPTSFESAWFIVFYLGGSVTVLLSTFYFATVLCDIDRKYLGEQNDAFCNFSVFTNSFLGVILLAPIIIGLYLLAVHLRNQKNANLNPKGSPRVASVLAILAPIPIIFLGLTGWGMGNEYLGKQCMANAEEAICAHGLAAYNAGLPMVVIWSVLGITVLVLACVYNRILPKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTQ6</accession>
    <name>A0A075MTQ6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02097</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTQ6"/>
    <dbReference type="KEGG" id="nev:NTE_02097"/>
    <dbReference type="HOGENOM" id="CLU_1056023_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="263" mass="30532" checksum="E718F5E3FA793B9F" modified="2014-10-29" version="1">MPQIDYSTASIQERKRRANELLSNLFQILEPKQKIDNPLDFLANELCKKIFDPGEESYLKNTKFADYRDALLEIVKITYRENRQKALTESLADMPEDDIFAIFQNMQKLNQRLTYLDKNHKTINKKVIDSYFSLYPEISNFFERVTLQLFGLKRILDGESITYSQLKLSKLSDYVNSLKTRPFFSELVQPMNITVRNAIVHGGNAVNPITRTIKFTDKRASVTMSYEDFIQATRELASATYVISHLDSAIKCIFINFIRSLPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTQ8</accession>
    <name>A0A075MTQ8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTQ8"/>
    <dbReference type="STRING" id="1459636.NTE_02521"/>
    <dbReference type="KEGG" id="nev:NTE_02521"/>
    <dbReference type="HOGENOM" id="CLU_2079313_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="117" mass="13321" checksum="5BBAAA67FA1F45AD" modified="2014-10-29" version="1">MLKTLKIALPVIMIMMSSLTSNKTALLSLLIVGVALASYALPIAAFAQNGGEDGKPKWNDKHWPQHNWDKESKSYKDDSGNEYKCETFHDGSYYYFYKGEFYKCDDYKPSSPSETPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTR0</accession>
    <name>A0A075MTR0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00588</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTR0"/>
    <dbReference type="STRING" id="1459636.NTE_00588"/>
    <dbReference type="KEGG" id="nev:NTE_00588"/>
    <dbReference type="HOGENOM" id="CLU_2765844_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="69" mass="7403" checksum="93831C0C29B1E7C1" modified="2014-10-29" version="1">MAMFKKSSHEFNTAAVITPHATTITATVTTATTVFLLSPSDSNISRRRLSVKGSLIRLAPFYLVGGCLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTR2</accession>
    <name>A0A075MTR2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00593</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699597.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTR2"/>
    <dbReference type="GeneID" id="41596456"/>
    <dbReference type="KEGG" id="nev:NTE_00593"/>
    <dbReference type="HOGENOM" id="CLU_2327135_0_0_2"/>
    <dbReference type="OrthoDB" id="6380at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="98" mass="11142" checksum="71A5FD7B13E046C2" modified="2014-10-29" version="1">MNYNNDAETLAGDCNAYLMHKYRFQPRHNQLVLGCRGLCARLETIGGGKNSAYSLGYKRCSSCDVYIKWDSCRCPCCKLPLRVKKRTKQHSSNIIPAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTW8</accession>
    <name>A0A075MTW8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UDP-N-acetylglucosamine 2-epimerase</fullName>
            <ecNumber evidence="2">5.1.3.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02143</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.1.3.14" evidence="2"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700813.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTW8"/>
    <dbReference type="STRING" id="1459636.NTE_02143"/>
    <dbReference type="GeneID" id="41597868"/>
    <dbReference type="KEGG" id="nev:NTE_02143"/>
    <dbReference type="eggNOG" id="arCOG01392">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041674_0_1_2"/>
    <dbReference type="OrthoDB" id="7018at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008761">
        <property type="term" value="F:UDP-N-acetylglucosamine 2-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03786">
        <property type="entry name" value="GTB_UDP-GlcNAc_2-Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003331">
        <property type="entry name" value="UDP_GlcNAc_Epimerase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029767">
        <property type="entry name" value="WecB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00236">
        <property type="entry name" value="wecB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43174">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE 2-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43174:SF1">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE 2-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02350">
        <property type="entry name" value="Epimerase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDP-N-acetylglucosamine 2-epimerase" evidence="1">
        <location>
            <begin position="21"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="373" mass="41517" checksum="D7CD07250F94BCE6" modified="2014-10-29" version="1">MKIASIVGARPNFIKLAPVHKALSKNPEIEHTIIHTGQHYDFEMSEIFFKEFKLPKPDINLQVGSGTPGYQTGEMIKRIEKELLRSSFDLVLVYGDTNSTLAGALAAVGSRTRLAHVESGLRSFDKRMPEETNRVLTDHISDYLFASTRMAVGNLRKESVQGRIIYSGDLSVEIVDEAVKAGAKSDVLDRLSLEYKSYVLLTIHRVENTTASPHNLATIIKAIEALKDTTIVFPIHPRTLQAIKDSHQLAAISRCQNLKLIKPLGYVDFVRLAHDASKIVTDSGGVQKEAFLLKVPCITVRQNTEWVETVSLGWNKLVGSSDARAIAEAVQKWMPARKKPQAVFGQGKTSAIVRDRIVSMLLQDQEKPERRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTX4</accession>
    <name>A0A075MTX4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Proton-translocating NADH-quinone oxidoreductase, chain M</fullName>
            <ecNumber evidence="10">1.6.5.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NTE_02551</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I subunit 4 family.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.3" evidence="10"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701139.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTX4"/>
    <dbReference type="STRING" id="1459636.NTE_02551"/>
    <dbReference type="GeneID" id="41598246"/>
    <dbReference type="KEGG" id="nev:NTE_02551"/>
    <dbReference type="eggNOG" id="arCOG01539">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007100_4_2_2"/>
    <dbReference type="OrthoDB" id="19089at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050586">
        <property type="entry name" value="CPA3_Na-H_Antiporter_D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010227">
        <property type="entry name" value="NADH_Q_OxRdtase_chainM/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003918">
        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_TM"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01972">
        <property type="entry name" value="NDH_I_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42703:SF1">
        <property type="entry name" value="NA(+)_H(+) ANTIPORTER SUBUNIT D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42703">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01437">
        <property type="entry name" value="NUOXDRDTASE4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="74"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="215"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="259"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="354"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="464"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="509"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="NADH:quinone oxidoreductase/Mrp antiporter transmembrane" evidence="9">
        <location>
            <begin position="182"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="115"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="120"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIF84598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="590" mass="63306" checksum="0F2C7912E6A846B9" modified="2014-10-29" version="1">MAESYFLLAATFIPLLLAPVAYVIGRRAGATAVTWFSFGALAISTGLLFIPTMLLHGGMTSYVETYKWGQFGDFGLRLDGLALPFALIIYVLCTVLAIYSKPYMIHKIMEDMPGHGKAGDGSSSSSSSSAPSHSSSHESPGHGGGTMMLLSPEQKQYVNSQMGLYFALYLAFSMGMLGTVLATNVIEFYVFFELMLVPSFFLIAFYGYGARRRIALMFFFWTHVGAVVLLLSLLAMGFFAGGYDFATIKANAGNIPQQWLALIVFGLVAGLGVKLAAFLLHIWLPYAHAEAPTPVSALLSPAMIGIGAYALLRLWLELLTGSYEQYSLYINMWGLATMIYGGAMALMQDDIKKVLAYSSISQMGYILFGLGSESILGISGATMLYVSHGLGKAVLFMMAGSIILQTGTRSMSRLGGLAGKMPYTAVIAFIGALTIMGVPPTSGFMAEWTMFNGALQTAAHNGDWFRAAMFGFGIMATILTSAYILWMLKRVFFGKIPEEMAHVKEASPYITMTMLVFAALSLTIGILPDLFLNPITGYIQGMFAGHENVLPLPEHSNAAIEPAAALGHESDGVSMQEGISAQTSGNGGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MU01</accession>
    <name>A0A075MU01_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02158</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700827.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MU01"/>
    <dbReference type="STRING" id="1459636.NTE_02158"/>
    <dbReference type="GeneID" id="41597882"/>
    <dbReference type="KEGG" id="nev:NTE_02158"/>
    <dbReference type="HOGENOM" id="CLU_999720_0_0_2"/>
    <dbReference type="OrthoDB" id="376375at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="270" mass="30459" checksum="CC47450ED57E8203" modified="2014-10-29" version="1">MVEMDRIHESLLDAGYKPRAMVSDLVYDAIIRAFELLGESCAGLLINHLSVIYRLPRHIVLTRYDLVSKAISQTFGYGSEVFMHEIRANLLRSLPHLDHSLSTIEIIRQAHKLEALRFVRNLRNGYAVFIHNNYSSKQEILDSFFKPVNAGRLINNNTTTTTATDGFGSAIIKYDRDGNITAGGRTYCNLVFCKHHYYYHPSKDQATQSRYVRRGTAAGSNNGRSRSFLCAYSADQASKDFTNIVLAHDHVITDQPFIVYSKSGHTHALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MU08</accession>
    <name>A0A075MU08_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00664</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MU08"/>
    <dbReference type="STRING" id="1459636.NTE_00664"/>
    <dbReference type="KEGG" id="nev:NTE_00664"/>
    <dbReference type="HOGENOM" id="CLU_873204_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="318" mass="34314" checksum="48C8D4E4CDE39756" modified="2014-10-29" version="1">MNLAAATGLTLDNNKKNPIFGAGRINQAPIGATKGTIAAGLAMFRKGSTSKKVGSLLAIFAVALAVISVVNFQFNIIREETRESILNDAKFIPTVKEISATIPHDKGTVVTVSSNGPHITYFTGLRAVSPYGVSSEPSLVDFMKSKKSEYLIVIENKADEPKLRPLFSSQGLKLLNGDFQKMSSYKSDQFTFHLYRLANSQSIEIVSPLAGDTISGPSTGVLVSVKGRLLSPSFAKDGDESFAKITKVEVVVDNLYPYQLAKPGSTEPDDWSSWSYQILITSEGTHQIVVRSTDSAGNQRWVGQSVKVVFTDNDGTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MU44</accession>
    <name>A0A075MU44_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MU44"/>
    <dbReference type="KEGG" id="nev:NTE_02183"/>
    <dbReference type="HOGENOM" id="CLU_3227634_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="43" mass="4813" checksum="82C2AA44F6097F0D" modified="2014-10-29" version="1">MTIFVLSNTLNFTILLNLHNCIAVFMLLLVLLVHSAHGVNYAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MU61</accession>
    <name>A0A075MU61_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NTE_03164</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_075055363.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MU61"/>
    <dbReference type="STRING" id="1459636.NTE_03164"/>
    <dbReference type="GeneID" id="41598822"/>
    <dbReference type="KEGG" id="nev:NTE_03164"/>
    <dbReference type="eggNOG" id="arCOG04548">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1507315_0_0_2"/>
    <dbReference type="OrthoDB" id="23833at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050572">
        <property type="entry name" value="Fe-S_Ferredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43687">
        <property type="entry name" value="ADENYLYLSULFATE REDUCTASE, BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43687:SF6">
        <property type="entry name" value="L-ASPARTATE SEMIALDEHYDE SULFURTRANSFERASE IRON-SULFUR SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13237">
        <property type="entry name" value="Fer4_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="62"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="122"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF85196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="178" mass="19715" checksum="6E71F4712772F5BC" modified="2014-10-29" version="1">MPIDPDFPRNHQVIGRINHSDGEHFHFFWGPGKVAEAAENEEVKHAYESHGEELVPLGVSGTMVAIDWDSCVADGACIEACPVQVYQWYRTEHDVPAKEAINQTFAGTGSSVKEERKDYTDKADPIREHDCIWCMACVSVCPPQAVKVDQSNLEFHEKAAGTFNEALSKSSQAPPHAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MU88</accession>
    <name>A0A075MU88_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutamine--fructose-6-phosphate aminotransferase [isomerizing]</fullName>
            <ecNumber evidence="2">2.6.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NTE_02223</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:13237"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="2.6.1.16"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.6.1.16" evidence="2"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MU88"/>
    <dbReference type="STRING" id="1459636.NTE_02223"/>
    <dbReference type="KEGG" id="nev:NTE_02223"/>
    <dbReference type="eggNOG" id="arCOG00057">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012520_7_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006047">
        <property type="term" value="P:UDP-N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00714">
        <property type="entry name" value="GFAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000006">
        <property type="entry name" value="Glutamine--fructose-6-phosphate aminotransferase [isomerizing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005855">
        <property type="entry name" value="GFAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047084">
        <property type="entry name" value="GFAT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01135">
        <property type="entry name" value="glmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001484">
        <property type="entry name" value="PRK00331.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937">
        <property type="entry name" value="GLUCOSAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE, ISOMERIZING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="GLUTAMINE--FRUCTOSE-6-PHOSPHATE TRANSAMINASE (ISOMERIZING)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13522">
        <property type="entry name" value="GATase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 11" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="9">
        <location>
            <begin position="5"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="10">
        <location>
            <begin position="278"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="10">
        <location>
            <begin position="442"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00055466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIF84277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="590" mass="63621" checksum="1A2AE0787C7BAFDD" modified="2014-10-29" version="1">MICVCSIIGYKGKQSAAPILVDSLKRMEYRGYDSVGVATFKDGDILVKKGTGKVAEVSKSLNISAMSGMIGIGHTRWATHGGVTDSNAHPHSACKNNIAVVHNGIIENYKELKEELIKTGHVFSSETDSEVIAHLLEVHADRGIKGSLTATCKRLKGTYAFVAVFQDGTIAGARYEEPLIIGVANDGYFISSDVLGFLQYTDKAIFLDNYDIVLVDGSKMEIFNFDGNPVAHPITQVAWELGEVDKGKYAHYTLKEINDQRVTVANAARQDEAMMEKFCKVLSDAKSVYITGSGTSYHSALIMKHMLARYAKIRAETVMSSEAQDGLVGLDEGSALVAFSQSGETADVLESVKIAKKQGAKILGIVNVTTSSLARASDAFLSVNCGPEIGVAATKSFTGQLALVYNIVSSLAPDTLAAGEKAEFVKAVEKVIASSQLAIEKMASKMEQVNDIYLLGRSTHYPIALEGALKLKELAYVHAEGVAAGELKHGPLALMEKNTLVILLNPRDATYNDSLSNAHEIKARGASVIGISDAGSEVYDHWVEIPHMTEEAFYPIVEVIPLQMLAYYLALAKNADPDYPRNLAKSVTVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUB3</accession>
    <name>A0A075MUB3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02253</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUB3"/>
    <dbReference type="STRING" id="1459636.NTE_02253"/>
    <dbReference type="KEGG" id="nev:NTE_02253"/>
    <dbReference type="HOGENOM" id="CLU_168025_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="99" mass="10910" checksum="ED8BE6629714475F" modified="2014-10-29" version="1">MVHFGINAPRTGKSMVYGTCVFCGEIFARNAKMQVCDKCEVILTWTSSINFLTAVNRLSALIKAGKLDSKLRNENYCKANFGTRGAQVIMDAIDGSQIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUF6</accession>
    <name>A0A075MUF6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987051.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUF6"/>
    <dbReference type="GeneID" id="41598922"/>
    <dbReference type="KEGG" id="nev:NTE_03267"/>
    <dbReference type="eggNOG" id="arCOG10411">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2519882_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="89" mass="9773" checksum="A3C28FA950153D87" modified="2014-10-29" version="1">MEQGRRHSKQTLKFSAQRLDNMTPELLAKSMWVSTGMAMIFSLPPLGLFIGLYEAEMHIGVAAGIGFGVHFATLAFSRRIAAGLSKLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUK1</accession>
    <name>A0A075MUK1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00913</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUK1"/>
    <dbReference type="STRING" id="1459636.NTE_00913"/>
    <dbReference type="KEGG" id="nev:NTE_00913"/>
    <dbReference type="eggNOG" id="arCOG11442">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1709038_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="153" mass="16853" checksum="80EF7D1A6A60B004" modified="2014-10-29" version="1">MAANVNLEQPNENSIVSDKEMIRSLIASVIQMGKDRGYEVIENHDLGAGSVHAVWNFKHGSESIPDLRLGFICLTDTSAFVINEAIARAMLNLVDKLVLIVPSEAMTKQVKDAIESMPDRSILQLRKYITVLTPSTLVSKSEIQSRDSATEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUK2</accession>
    <name>A0A075MUK2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Class I SAM-dependent methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03312</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUK2"/>
    <dbReference type="STRING" id="1459636.NTE_03312"/>
    <dbReference type="KEGG" id="nev:NTE_03312"/>
    <dbReference type="eggNOG" id="arCOG02703">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1052177_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="273" mass="31226" checksum="2C24896F482ACC4A" modified="2014-10-29" version="1">MPFKLEELQKAHEAYRQFAEKNPPAHHARYIFPFFTGSYFAYRKVDVLRVVAVAKAVNDNPDYLDVGCGYGDFLKRVREYLPGASGVEKEGGIFYALGATKPDYIGIAPVESLSRPVDIAFVGWMEPGTDFRRQVAKTARCIITTFDAGGQCGINGGCEYDEFGFERIAWWRTPSWIDVNAELMNRYYTPSLSEEKKRHLASLRSAHNFWYVYAKPELADKIREALAYIAKKEDAKKEERYDFESVLDECGFGYKEELATVTTAKRLWEVILD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUL6</accession>
    <name>A0A075MUL6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7482 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701774.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUL6"/>
    <dbReference type="STRING" id="1459636.NTE_03327"/>
    <dbReference type="GeneID" id="41598977"/>
    <dbReference type="KEGG" id="nev:NTE_03327"/>
    <dbReference type="eggNOG" id="arCOG08764">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_558549_0_0_2"/>
    <dbReference type="OrthoDB" id="10704at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055905">
        <property type="entry name" value="DUF7482"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24298">
        <property type="entry name" value="DUF7482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7482" evidence="1">
        <location>
            <begin position="355"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="557" mass="58557" checksum="AFE688E1260B0384" modified="2014-10-29" version="1">MNNARKRSQTFCIGGTAAILLSALVLFALGSGATGSNNGGTAAYAAEMMEEKSNHMMTGDSAMKGKADDSMTMMAMENNKAGPHVIKGQISNVQVGGNGQPEWIQSGIWVARITNAAAGAGSEKPLPSANLIARFSMIKPDGTSAHQHSIYNFKVMEMTMEGNSTHVLKGTATVTMPGGPVNDVPLTVKVFNNSVVGFWIGPDKVNGHFGSNPIFGILSLASKGMMNDMMSMMMVEGGTTTTMEQNLTKTALPLTLPLTRGYANGHEVFYISTEASDKGLADHLTNVTGSRVAYAPSLSHTPASSLANIYAFKNGIAGSGPLGFQPNVADSQPGDAKYSPIWRIITVEWKQGVSATELKSEQEILAAAQEGKVTIEPTSMLVNCPFVQWEGGKLMERADKALTDKSPYGPGQVLSIDTQKMQVTFVAHRGFAPDGSTIYYIATDASSQDAAKALGVTFVNKTAGTVLSGASSDLYVFTNGIKGTGPMGFQASIAGSNVGDTLYSPLWRINAATWKDPSMAKFLTTSGQISSEVSDGMLSTAVAGFVVNCPFVEVDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUP1</accession>
    <name>A0A075MUP1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03358</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUP1"/>
    <dbReference type="KEGG" id="nev:NTE_03358"/>
    <dbReference type="HOGENOM" id="CLU_3302556_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="39" mass="4667" checksum="F8D9D11FC65A7707" modified="2014-10-29" version="1">MRLDEKRVKLWLQHFSLLTLKKQWNHTHVSGHGDGTQIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUT2</accession>
    <name>A0A075MUT2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Phosphoribosylformylglycinamidine cyclo-ligase</fullName>
            <ecNumber evidence="4 15">6.3.3.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 15">AIR synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13 15">AIRS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11 15">Phosphoribosyl-aminoimidazole synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">purM</name>
        <name evidence="18" type="ORF">NTE_02880</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 15">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the AIR synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.1" evidence="4 15"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148702175.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUT2"/>
    <dbReference type="STRING" id="1459636.NTE_02880"/>
    <dbReference type="GeneID" id="41598560"/>
    <dbReference type="KEGG" id="nev:NTE_02880"/>
    <dbReference type="eggNOG" id="arCOG00639">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047116_0_0_2"/>
    <dbReference type="OrthoDB" id="6605at2157"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00129"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004637">
        <property type="term" value="F:phosphoribosylamine-glycine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004641">
        <property type="term" value="F:phosphoribosylformylglycinamidine cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046084">
        <property type="term" value="P:adenine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02196">
        <property type="entry name" value="PurM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.10:FF:000020">
        <property type="entry name" value="Phosphoribosylformylglycinamidine cyclo-ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.650.10:FF:000011">
        <property type="entry name" value="Phosphoribosylformylglycinamidine cyclo-ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="entry name" value="PurM-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="entry name" value="PurM-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00741">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004733">
        <property type="entry name" value="PurM_cligase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00878">
        <property type="entry name" value="purM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520:SF12">
        <property type="entry name" value="TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520">
        <property type="entry name" value="TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="PurM C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="PurM N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 15 18" id="KW-0436">Ligase</keyword>
    <keyword evidence="8 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 15" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PurM-like N-terminal" evidence="16">
        <location>
            <begin position="42"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="PurM-like C-terminal" evidence="17">
        <location>
            <begin position="172"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00033093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="AIF84918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="345" mass="36744" checksum="707E8690D5B7E3FE" modified="2014-10-29" version="1">MTYRDAGVDVGKIRTAQKSIGDIISATHNMISAGKVLSGFGHYAGLVRLGSQTLALHSDGVGTKVLVAQLMNKFDTVGIDCVAMNVNDIICVGAKPVAFIDYIALRQANEKLLEQIAHGLVEGARQSQMAIVGGETAVLPDVIAGEENAFDLAGMVLGTVDGGKPLLGSAIKPGDVVLGVESSGLHSNGYTLARKVLLSKYSVDDNAEHLVQTVGEELLIPTRIYVKPVMELFKKKIAVHGLANITGGSFTKLPRLNKNVQYCLDDLPAPTGIFRQIQVDGNIETGEMYRTFNMGTGFCVIAPKASAEQVIRTFKRYKMGCKAIGRIEKGAGVVATLEGKKKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUV8</accession>
    <name>A0A075MUV8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02955</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385573.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUV8"/>
    <dbReference type="GeneID" id="43502666"/>
    <dbReference type="KEGG" id="nev:NTE_02955"/>
    <dbReference type="HOGENOM" id="CLU_3162930_0_0_2"/>
    <dbReference type="OrthoDB" id="378672at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="47" mass="5045" checksum="51567597F5F525C5" modified="2014-10-29" version="1">MTSANATDDDKEISKLISFGVDAEFAKTLPRAARRQILKGILGLQGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MV23</accession>
    <name>A0A075MV23_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transposase, IS605 OrfB family, central region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NTE_03055</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the transposase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MV23"/>
    <dbReference type="STRING" id="1459636.NTE_03055"/>
    <dbReference type="KEGG" id="nev:NTE_03055"/>
    <dbReference type="eggNOG" id="arCOG00684">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032903_0_1_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Cas12f1-like_TNB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051399">
        <property type="entry name" value="RNA-guided_DNA_endo/Transpos"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021027">
        <property type="entry name" value="Transposase_put_HTH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040570">
        <property type="entry name" value="guided_TnpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01766">
        <property type="entry name" value="IS200/IS605 family accessory protein TnpB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30405:SF25">
        <property type="entry name" value="RNA-GUIDED DNA ENDONUCLEASE INSQ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30405">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="Cas12f1-like_TNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12323">
        <property type="entry name" value="HTH_OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0815">Transposition</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Transposase putative helix-turn-helix" evidence="10">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="Probable transposase IS891/IS1136/IS1341" evidence="8">
        <location>
            <begin position="166"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Cas12f1-like TNB" evidence="9">
        <location>
            <begin position="280"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIF85090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="394" mass="45671" checksum="1F035A830486F9D9" modified="2014-10-29" version="1">MMRNYKFRLYPTREVEQKLVETLEINRVVYNYFVSSNLRSRNDMNYALTELKERQPILRKYHSKMLQMVSTKVAAAWRALEVLEEHGRRTGSLKFCKPGKCNSFTYNQSGFRIENDKLWLLKIGSIKIVLHRQPTKVKQVMVVRQARKWYAVVTCEIAKSIFRFVDTRKSIGIDVGITKFAYDSDDHEIDNPLFLSKMIRPLRRAQRKVSRRKRGSNNRKKAKSWVAHLYQRIANKRHDFLHKLSTEYASKYDLIFLERLRISNMVKNHHVARHIMDSGWGTFKTMLEYKAKMVVGVGPAYTSINCSKCGNTVPKTLAVRLHRCNKCGLTLDRDYNASLNILNEGLTTLPQGLREFTPVEIAPLLASVGVQARSLKQEASLFKAQAIHSAERSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MV49</accession>
    <name>A0A075MV49_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dihydroorotate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NTE_01086</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385122.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MV49"/>
    <dbReference type="STRING" id="1459636.NTE_01086"/>
    <dbReference type="GeneID" id="41596902"/>
    <dbReference type="KEGG" id="nev:NTE_01086"/>
    <dbReference type="eggNOG" id="arCOG00603">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_661598_0_0_2"/>
    <dbReference type="OrthoDB" id="36608at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004152">
        <property type="term" value="F:dihydroorotate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009220">
        <property type="term" value="P:pyrimidine ribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050074">
        <property type="entry name" value="DHO_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48109:SF4">
        <property type="entry name" value="DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48109">
        <property type="entry name" value="DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroorotate dehydrogenase catalytic" evidence="6">
        <location>
            <begin position="67"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF83159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="393" mass="43825" checksum="1F909E1662AC43E5" modified="2014-10-29" version="1">MLAVDTFKASLDPSLFKLYRRYLYSRYKATDELAQGEVVHEIAKERLVRLAGKFEKNASYFDPGEQLALSINGLELKSPVGVAAGFDKNCDMLLPMSYVFGYMNPGSVLLKPRAGNLQKPRSEGTVRMAIDDERQAIINAQGYPHKGLEHTVRNLQKFSQEKHHHRGGRARILLNFSGITDSYTEDAVLDACREILVRTSPYVDLGFEENRTSPNTDFNKVLQSPDFTKKMVDLMNAHVPSGKLKASKIAPYSELPPKDAEREARMKSIKVFYENGGQAVVIGNTRPVGTSLLAAKFSRPVAGESGRPLFPYMLRMVEDVHKAFPGLAIIACGGIWNGEDAWQAYQKGATLVQLYTALTFQGFGIVREIHDTLKKKLAGQTLQGFIEKRDNHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MV60</accession>
    <name>A0A075MV60_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_02493</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MV60"/>
    <dbReference type="KEGG" id="nev:NTE_02493"/>
    <dbReference type="HOGENOM" id="CLU_145173_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF84542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="122" mass="14159" checksum="CE58B8BEBB64BE63" modified="2014-10-29" version="1">MKDHSSEKKGTAHENLLEILDNVIRQLDFTKKMIIIMVISFITVVPVSAVVINAVTGGNNLGVAIPIIAVTVFFIWLGVGIRQWIVFSRWTRKYRLYRQLQKDLEKRLDFEKNNEEKSQEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MV89</accession>
    <name>A0A075MV89_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Helix-turn-helix domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03143</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701619.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MV89"/>
    <dbReference type="GeneID" id="41598802"/>
    <dbReference type="KEGG" id="nev:NTE_03143"/>
    <dbReference type="eggNOG" id="arCOG04362">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062767_3_0_2"/>
    <dbReference type="OrthoDB" id="11410at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="268" mass="30494" checksum="B78851A8F34CEC9C" modified="2014-10-29" version="1">MSDQAPVSDGEVFLELASGMRRSILIALDGKKLKLSQLAESLDMTIQESHRQFARLANAGLVRKDSEGLLSLTACGRIVAKQIPCFDFLERNELYFRDHSFGELPLKFIQRLAALNNSEPVDGVVAVLERWKGMLLEAKEHVWCISPQIPLDVSMLGIEVLTKGVKLSLLLSKNTIAPKGSLDEIDKRLRGLISKGTVERRMMEKASIAVVFNERQYSCVGFANSRGDGDLNYMFFSRDPHFFEWCYDYFQYEWSRSDDWDGSRIREI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVL0</accession>
    <name>A0A075MVL0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FeS assembly ATPase SufC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_01244</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700103.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVL0"/>
    <dbReference type="STRING" id="1459636.NTE_01244"/>
    <dbReference type="GeneID" id="41597050"/>
    <dbReference type="KEGG" id="nev:NTE_01244"/>
    <dbReference type="eggNOG" id="arCOG04236">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_48_1_2"/>
    <dbReference type="OrthoDB" id="18492at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03217">
        <property type="entry name" value="ABC_FeS_Assembly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010230">
        <property type="entry name" value="FeS-cluster_ATPase_SufC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01978">
        <property type="entry name" value="sufC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43204">
        <property type="entry name" value="ABC TRANSPORTER I FAMILY MEMBER 6, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43204:SF1">
        <property type="entry name" value="ABC TRANSPORTER I FAMILY MEMBER 6, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="3">
        <location>
            <begin position="4"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF83314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="258" mass="28439" checksum="5FF37FEED8E3AAB6" modified="2014-10-29" version="1">MAFLEIKDLHVSIDGKQILDGLNLSIDKGEVHAIMGPNGSGKSTLANAIMGHPKYTLDSGEIKVKGEVINNLSTDLRARKGLFLGFQYPTEISGVGYSHFLRNAYNQLNKSLGEEQNREVFLTVREFHEYVKRNLDAVGLDPSFLGRYLNEGFSGGEKKRSEVMQMLVLKPNIAILDEPDSGLDIDAVKAVAEAINKLIDTGAGVLVITHYARILRYMKKLDHVHVVAKGKVIKSGGKELSEELEAKGYGWLGIEDDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVQ3</accession>
    <name>A0A075MVQ3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Hydroxymethylglutaryl-CoA synthase</fullName>
            <ecNumber evidence="6">2.3.3.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NTE_01316</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiolase-like superfamily. HMG-CoA synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.10" evidence="6"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700165.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVQ3"/>
    <dbReference type="STRING" id="1459636.NTE_01316"/>
    <dbReference type="GeneID" id="41597118"/>
    <dbReference type="KEGG" id="nev:NTE_01316"/>
    <dbReference type="eggNOG" id="arCOG01767">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008065_3_2_2"/>
    <dbReference type="OrthoDB" id="5812at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004421">
        <property type="term" value="F:hydroxymethylglutaryl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006084">
        <property type="term" value="P:acetyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010142">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00827">
        <property type="entry name" value="init_cond_enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013746">
        <property type="entry name" value="HMG_CoA_synt_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013528">
        <property type="entry name" value="HMG_CoA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43323">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43323:SF2">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08540">
        <property type="entry name" value="HMG_CoA_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01154">
        <property type="entry name" value="HMG_CoA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hydroxymethylglutaryl-coenzyme A synthase N-terminal" evidence="4">
        <location>
            <begin position="4"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Hydroxymethylglutaryl-coenzyme A synthase C-terminal" evidence="5">
        <location>
            <begin position="181"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF83384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="466" mass="52205" checksum="C078A33667577543" modified="2014-10-29" version="1">MPVVGIDDLAIYVPKLYIDYKDFAQARGIDPQKLEYGIGIRKMAIADTNQDPACMAANACLKLMQKAHLHPQDIGRLYVATESALDESKALNSFVIGMLEQVYGEGSFEHAGGIECKFACVSGSYALHDNANWIRAEENSGKAAIVIVSDIAKYDLGSAGEYTQGAGAVALLIKEEPRLMAFDPKVASTVIKNEYDFYRPFGKETPLVNGGYSNLLYLIQVRKAFDAYKEKALKTGLVKLNEGEAITDHIDFFSVHLPYRRMGEKALAYLLRHEWRHLPRWKHVTKEIGMNEPQPKDPRGTIESILADTDFMKADEQFRRAFMQTSFYNETYEKKMASSLEASAQIGNLYTASMYMGLRSLLEFEFKKGTDLEGKRVGFGSYGSGSSAMVFSGIMQPTYKEIVKSLDLENDIGDRVKLSIDEYERLHRKEIDFNSAVTKAHKEFVLVKLGGSTADKAGFREYDYVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MW66</accession>
    <name>A0A075MW66_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02839</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701377.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MW66"/>
    <dbReference type="STRING" id="1459636.NTE_02839"/>
    <dbReference type="GeneID" id="41598521"/>
    <dbReference type="KEGG" id="nev:NTE_02839"/>
    <dbReference type="HOGENOM" id="CLU_1830506_0_0_2"/>
    <dbReference type="OrthoDB" id="12071at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055898">
        <property type="entry name" value="DUF7475"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24287">
        <property type="entry name" value="DUF7475"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="139" mass="14764" checksum="D7D118EC1D542175" modified="2014-10-29" version="1">MPTNNNTRAATTTATSRWLYYAAAGATAIAGILHLYMGPGTLGFNANTGVFFIVSGIAQLFWVVPMIKRWGRPWYAVGIAGTAVLVAIYFVTRMPGNPITGRGGPLNAMGAVTEIAQFAFIGLAVAILVMESRRRRAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MW95</accession>
    <name>A0A075MW95_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Urease accessory protein UreD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ureD</name>
        <name evidence="4" type="ORF">NTE_02884</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the UreD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_193354075.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MW95"/>
    <dbReference type="STRING" id="1459636.NTE_02884"/>
    <dbReference type="GeneID" id="41598563"/>
    <dbReference type="KEGG" id="nev:NTE_02884"/>
    <dbReference type="eggNOG" id="arCOG04529">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056339_1_0_2"/>
    <dbReference type="OrthoDB" id="10701at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01384">
        <property type="entry name" value="UreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002669">
        <property type="entry name" value="UreD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33643">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33643:SF1">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01774">
        <property type="entry name" value="UreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF84922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="316" mass="35151" checksum="B39A7B496C904034" modified="2014-10-29" version="1">MMAKTTVNDLAYYIPDAIPPEVQAYGSKLDQLGVGNPGKLGGLILRLEKDEHNGKTSVKEQYSRVPLYTGRALYLEEALPSMAYLYIISPSGGILQGDRYRMDITLRNNALAHITTQGATRIYRMEKNFATQIVNVDVGEGCYFEYIPDQIIPYVDSRFYQVANLRVHDSATMLYSEIMTPGRVARGESFAYDICYMKTQATNQDGDMRFVDVAIMEPKKRSMKAFGVLDNYDTVGSTYVLAPSKYVAELHDKINSGLAGYSKDLYFGASILPNNSGVIVRMLGDTASLLRNAVFEVVRAARKTILHAPFSGIRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWD2</accession>
    <name>A0A075MWD2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01526</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWD2"/>
    <dbReference type="STRING" id="1459636.NTE_01526"/>
    <dbReference type="KEGG" id="nev:NTE_01526"/>
    <dbReference type="eggNOG" id="arCOG04362">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_835763_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="332" mass="37822" checksum="C4D6BB1EBE149545" modified="2014-10-29" version="1">MPISHSKFANPDSYRNPRLSKQIRKILADDIAVRLLYMAHEGFLAKNFAYKSMGITRKQYYSRLKPLIKLQFIEKVASSDTGRRNKSMYVATTLGKMIFRTQVRMIEELSENIENVNLIERIKTDYQHIGNDKIAKISTILLDNTSVLRDVFASMGNKHDLDVLSDYETAISTSCDLISKAKSRVLVASRYVHPDAVKEMVRAASYNNIEVRSIIEQSILAKRIADLKVDSEEKLNANAQLLFPAITSGIKYRYSEVYYTFLVVDNLVSIIEVLSPFDQQFLLALKFNSRAISERLGAIFESMWKRSMMPYESAASYLSSSSHAPSSIIKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWD3</accession>
    <name>A0A075MWD3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03415</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701853.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWD3"/>
    <dbReference type="GeneID" id="41599058"/>
    <dbReference type="KEGG" id="nev:NTE_03415"/>
    <dbReference type="HOGENOM" id="CLU_1902007_0_0_2"/>
    <dbReference type="OrthoDB" id="11547at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="134" mass="15256" checksum="25D2FAB01ABCCA06" modified="2014-10-29" version="1">MESGISSQQLDNFNLLPFWKKNESLLKEIEQSETPAKSRLIFKEVSTNQGANGEQIVTSYDLVNIYGNRKNFFSIIAYLSRDGSSVIREEIIAGNKLSNAKKTVIDGSKITNKDQIEWIKEMSRNGMCRLFRTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWF3</accession>
    <name>A0A075MWF3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Plastocyanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01546</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700350.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWF3"/>
    <dbReference type="STRING" id="1459636.NTE_01546"/>
    <dbReference type="GeneID" id="41597330"/>
    <dbReference type="KEGG" id="nev:NTE_01546"/>
    <dbReference type="HOGENOM" id="CLU_088474_0_0_2"/>
    <dbReference type="OrthoDB" id="4392at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052721">
        <property type="entry name" value="ET_Amicyanin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36507">
        <property type="entry name" value="BLL1555 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36507:SF1">
        <property type="entry name" value="BLL1555 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="226" mass="23716" checksum="27C4A87ACD5C3DAC" modified="2014-10-29" version="1">MNRYFIIALAIAASAVLAISTVTATTMAANDQSVAHSVGASMKFMDYKDGVFKVMAGGGGPTAPLTKFFPAKATIKVGESVTWVNPTRVGEPHTVTFVLNQTQGANLDVPFVVNNSTGIAPLAPGNSAPITLPGPNGTTAMIGANAMAYLPVTIASDGTVTPMPPNANYTMNGTEQYINSGFIWPKGMAPEGLPPIDTFTVKFEKAGTYDYLCILHPWMTGQVQVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWJ9</accession>
    <name>A0A075MWJ9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03475</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWJ9"/>
    <dbReference type="KEGG" id="nev:NTE_03475"/>
    <dbReference type="HOGENOM" id="CLU_2874908_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="63" mass="7352" checksum="6B74332D8F9AA5D2" modified="2014-10-29" version="1">MPFELPAEITYLLLASKTKTALFCNKWLINNSAISKQLERSFCIKRNTLEVFFNQLLIRVIMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWU9</accession>
    <name>A0A075MWU9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dodecin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03093</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701577.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWU9"/>
    <dbReference type="GeneID" id="41598754"/>
    <dbReference type="KEGG" id="nev:NTE_03093"/>
    <dbReference type="HOGENOM" id="CLU_161196_2_1_2"/>
    <dbReference type="OrthoDB" id="187186at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1660.10">
        <property type="entry name" value="Flavin-binding protein dodecin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009923">
        <property type="entry name" value="Dodecin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025543">
        <property type="entry name" value="Dodecin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036694">
        <property type="entry name" value="Dodecin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39324">
        <property type="entry name" value="CALCIUM DODECIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39324:SF1">
        <property type="entry name" value="CALCIUM DODECIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07311">
        <property type="entry name" value="Dodecin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89807">
        <property type="entry name" value="Dodecin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="71" mass="7878" checksum="30D0EF7C0E9E18CE" modified="2014-10-29" version="1">MSVIRVTEILATSPTSWEDAVNNGLERATKTIRNVKGIDVLGWKAEIQNEKIVEYRVSMKVAFEVEDGPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MXD3</accession>
    <name>A0A075MXD3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative xylanase/chitin deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03248</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701708.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MXD3"/>
    <dbReference type="STRING" id="1459636.NTE_03248"/>
    <dbReference type="GeneID" id="41598903"/>
    <dbReference type="KEGG" id="nev:NTE_03248"/>
    <dbReference type="eggNOG" id="arCOG02876">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_958524_0_0_2"/>
    <dbReference type="OrthoDB" id="377943at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0858">Xylan degradation</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="52"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="303" mass="33619" checksum="ACA0049396D710F8" modified="2014-10-29" version="1">MVHIRKNVTIIVVASALLLATGAMFVIQQQKQALARHTSPDGQSSSSPTRCNCVIFRADDIQDYWKQEPQVALLDIFISKSVPLSVGLVMNHYGSDRLIVDKVREGGPLFEYDIHGWDHVDYTTLSAQQQEESISQAQAKIESVMGKDAKVFFAPYNNFDTNTLIAMKLGGLKIISASKADTSPYAPANDTLGILHMPQSINYGYANSTSERHAWRTVAEMKSVVEADIEVRGWAVVTIHPQDFAKYDDGEENGGKMLNVADEQRVDTFKTFIDQLRAEGKTLTTFEGAVRIMDGDDVHPDLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MXP4</accession>
    <name>A0A075MXP4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Transcription termination factor FttA</fullName>
            <ecNumber evidence="12">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">fttA</name>
        <name evidence="16" type="ORF">NTE_02012</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Terminates transcription on the whole genome. Termination is linked to FttA-mediated RNA cleavage and does not require NTP hydrolysis. Cleaves endonucleolytically at the RNA exit channel of RNA polymerase (RNAP); the 5'-3' exonuclease activity of this protein degrades the nascent RNA released from RNAP.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 2 Zn(2+) ions, which are required for nuclease activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homodimer. Interacts with RNA polymerase (RNAP), interacts with the Spt4-Spt5 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. FttA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="12"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700717.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MXP4"/>
    <dbReference type="STRING" id="1459636.NTE_02012"/>
    <dbReference type="GeneID" id="41597758"/>
    <dbReference type="KEGG" id="nev:NTE_02012"/>
    <dbReference type="eggNOG" id="arCOG00543">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009673_5_1_2"/>
    <dbReference type="OrthoDB" id="7155at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004532">
        <property type="term" value="F:RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22532">
        <property type="entry name" value="KH-II_CPSF_arch_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16295">
        <property type="entry name" value="TTHA0252-CPSF-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00870">
        <property type="entry name" value="FttA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019975">
        <property type="entry name" value="aCPSF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050698">
        <property type="entry name" value="MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033769">
        <property type="entry name" value="TffA_KH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03675">
        <property type="entry name" value="arCOG00543"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203:SF51">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17214">
        <property type="entry name" value="KH_TffA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 12" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 12" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 12" id="KW-0540">Nuclease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 12" id="KW-0806">Transcription termination</keyword>
    <keyword evidence="6 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="14">
        <location>
            <begin position="257"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-Casp" evidence="15">
        <location>
            <begin position="485"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Beta-Casp" evidence="12">
        <location>
            <begin position="448"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="394"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="416"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="416"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="665"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AIF84069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="698" mass="77363" checksum="6564F644B9D725AA" modified="2014-10-29" version="1">MEKNEIKEFEEQAQTQRRPRPEQQQRRSAQAQVASAANHVTKVTTESEDDVAKIILQSIPADSQITNVRFEGPNIALYTKNPKFALTDLTYYLSSLSKTLKKRFIIRTDPAVRLPEDATRQAVVKLLPKDVQVSAVFCDDATGEVVLEVSRPEAIDPAMIVEIARTTGWIAHTRRSPHIPSTSINTIHSTLKGSAKERTDFLQKLGTRLFRGPLVVGNVSENGNGRSEPSDVSPRPQWSQNREEVMLFCLGGVKQVGRSCFIVVTPESKVMLDCGINPGEMSGLDAYPRIDWLNFNLDELDAVVISHAHIDHQGFLPALFKYGYRGPVYCTEPTLPLMTLLQMDSVKIANSNGTYLPYEARDVHEVIKRTITLPYGKPTDISPDITVTLNNAGHIMGSATVHLNISGAHNILYSGDYKYARTQLLDSAVATYPRVETLITESTYGNTSDIMPDQAFVYRTFSESINKVLSEGGKVLIPVPAVGRAQEIMLVMAKEMSEGRLVESPIYIEGMISEASAIHMSYAHYLGADVRRSVSQGINPFTSEYFTVISGGKREEAINDQNPAIIMATSGMLEGGPSVEYFKELAPNPKNKIIFVSYQINGTLGRRVLDGNVSEVSMMDKSGKVKVVPVRCQTQKIDGFSGHSDFNQIMNFVAKIKPKRVLINHGERTKSENVASAIYSRLKIRSGVPDNREIVRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MXQ1</accession>
    <name>A0A075MXQ1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03359</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MXQ1"/>
    <dbReference type="STRING" id="1459636.NTE_03359"/>
    <dbReference type="KEGG" id="nev:NTE_03359"/>
    <dbReference type="HOGENOM" id="CLU_1458139_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="185" mass="20628" checksum="C78D908A65926E88" modified="2014-10-29" version="1">MMRKSSIIPVVGLVLLTSLPLAAPGVGTTSYNHAAIAIIQSPIRSLHTTKMMISNETAAQIVADSHLPGIQNDTVARTVGFDFWQYNGTIPWGNDTRPDYIVYEANPETLSVNRTHTLAFISYAGDHAFLMPKNDTSDKYVWVVRDFRSNERYAYFLHRDFYLYFVDAFSGKILAYGCASCGVCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MYG4</accession>
    <name>A0A075MYG4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_02255</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385410.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MYG4"/>
    <dbReference type="STRING" id="1459636.NTE_02255"/>
    <dbReference type="GeneID" id="41597971"/>
    <dbReference type="KEGG" id="nev:NTE_02255"/>
    <dbReference type="eggNOG" id="arCOG03118">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125997_2_0_2"/>
    <dbReference type="OrthoDB" id="10459at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051311">
        <property type="entry name" value="DedA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="VTT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42709">
        <property type="entry name" value="ALKALINE PHOSPHATASE LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42709:SF4">
        <property type="entry name" value="INNER MEMBRANE PROTEIN YQAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="VTT_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="VTT" evidence="2">
        <location>
            <begin position="50"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF84309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="173" mass="18902" checksum="9AE7B0D892F6E5F8" modified="2014-10-29" version="1">MIVDQYLQYVQEIISKLATNPIFIEFGLTGLFVNSVLASTALPLPIEIAVSALLAAGQDKFLVFLTLAAGTVAGGFLSYFIGKSGDKVFRFLKPKSQEENKQNKKSHEILTKYGWLALVAAPWIPVFGDIIIMIAGAKSYDFRKFTIAMTAGKIVKAVATVYFIGLITTRLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MZS4</accession>
    <name>A0A075MZS4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription initiation factor TFIIIB, Brf1 subunit/transcription initiation factor TFIIB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385533.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MZS4"/>
    <dbReference type="STRING" id="1459636.NTE_02686"/>
    <dbReference type="GeneID" id="41598376"/>
    <dbReference type="KEGG" id="nev:NTE_02686"/>
    <dbReference type="eggNOG" id="arCOG08817">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2730538_0_0_2"/>
    <dbReference type="OrthoDB" id="9973at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="Zn_Ribbon_TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TFIIB-type" evidence="1">
        <location>
            <begin position="4"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="71" mass="8408" checksum="4290DD42F05FAEA1" modified="2014-10-29" version="1">MVSYCPECGGELKFDLASKNFICKSCGLFASREKIDELRDKADARKEDMRQKKHDDYIDWWQSSKKDKQQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N012</accession>
    <name>A0A075N012_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">Protein translocase subunit SecY</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Protein transport protein SEC61 subunit alpha homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">secY</name>
        <name evidence="15" type="ORF">NTE_02794</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the Sec protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10 13">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701342.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N012"/>
    <dbReference type="STRING" id="1459636.NTE_02794"/>
    <dbReference type="GeneID" id="41598482"/>
    <dbReference type="KEGG" id="nev:NTE_02794"/>
    <dbReference type="eggNOG" id="arCOG04169">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031763_3_0_2"/>
    <dbReference type="OrthoDB" id="371914at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="entry name" value="SecY subunit domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01465">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026593">
        <property type="entry name" value="SecY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030659">
        <property type="entry name" value="SecY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019561">
        <property type="entry name" value="Translocon_Sec61/SecY_plug_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00967">
        <property type="entry name" value="3a0501s007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006341">
        <property type="entry name" value="PRK08568.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10906">
        <property type="entry name" value="SECY/SEC61-ALPHA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10559">
        <property type="entry name" value="Plug_translocon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00344">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004557">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00303">
        <property type="entry name" value="SECYTRNLCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="Preprotein translocase SecY subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="8 10 12" id="KW-0811">Translocation</keyword>
    <keyword evidence="5 10 12" id="KW-0812">Transmembrane</keyword>
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            <begin position="38"/>
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            <end position="170"/>
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            <end position="201"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
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            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="280"/>
            <end position="306"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="437"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Translocon Sec61/SecY plug" evidence="14">
        <location>
            <begin position="46"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01465"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF10559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AIF84834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="477" mass="51639" checksum="8923FDFA6D625CCC" modified="2014-10-29" version="1">MSSTTQNENVLRRVIRSASAYVPQVPKPKKKISLTEKFAWTGIALLLYLVMGQIPLYGVTSDPKFDFLAFARVIFAAQQGTLMELGIGPIVTAGLLMQLLKGSDLIRLDFKNPDDRSLFTSATKIVTIIVIVAEGSLYGISVYGPLVGGPQIIAIVVAQLISASILVMLLDELVQKGWGIGSGLSLFIMAGIAQTILWSVFSPFPAQDGPTGILPFTIQSTIEGHGQDAIFRSGQLPSIFGLGLTVAVILVLVYIEGIHVDIPIVSTKYRGFTAVYPIKLLYTSVIPVILSSALIANAVFMGQMMWTNYNPNNTNPAFNWIAQFDPSSPQTPTGGILYYITSPRSLDHVAADPVRAVVYVIFFVTIVTIFSRLWVELGGLSAKTAAKNLLDADVQVPGFRRSENSVESLLNRYIPSLTIISGVIIGLLASLSDILNVFGSGTGILLMVNIMVSYYQTLVKEQVDTYMPKLAALLGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N048</accession>
    <name>A0A075N048_9ARCH</name>
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        <submittedName>
            <fullName evidence="9">Rieske Fe-S protein</fullName>
            <ecNumber evidence="9">1.10.2.2</ecNumber>
        </submittedName>
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    <gene>
        <name evidence="9" type="ORF">NTE_02836</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
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            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
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        <property type="protein sequence ID" value="AIF84874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="STRING" id="1459636.NTE_02836"/>
    <dbReference type="GeneID" id="41598518"/>
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        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5623at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Rieske_Fe-S_prot"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR10134">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00162">
        <property type="entry name" value="RIESKE"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TAT"/>
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    </dbReference>
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    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
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    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="Rieske" evidence="8">
        <location>
            <begin position="81"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF84874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="209" mass="23256" checksum="D4D0E2558245B35D" modified="2014-10-29" version="1">MKEVKSGRNTGGGWNPKTSRRDFLKLMVAVGTVFTFAPFVDWGKFLPNPQTNVPAKAKAELPDGSQANVNTFPVNSSQVVIYPKTNDEVLNQEAFRTWQFIRLPEELGGTKNDVSAFRMYSSVCLHLWCLWKYFPDPGRKRGECPCHGSMYDPMNGKAFAGPASLQAPPTNVLPELDLEADEKGDIWIKPANWSVNGNGIVGYGRFLNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N0C0</accession>
    <name>A0A075N0C0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_02901</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N0C0"/>
    <dbReference type="STRING" id="1459636.NTE_02901"/>
    <dbReference type="GeneID" id="41598580"/>
    <dbReference type="KEGG" id="nev:NTE_02901"/>
    <dbReference type="HOGENOM" id="CLU_3057260_0_0_2"/>
    <dbReference type="OrthoDB" id="379078at2157"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF84939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="60" mass="6745" checksum="2EDF88D4B21A6144" modified="2014-10-29" version="1">MFEEAITVAAIIGGSAAAVWYAKSKFQPGIERDLERIESATYERPESLHRAHNNNNNNQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N1C1</accession>
    <name>A0A075N1C1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701696.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N1C1"/>
    <dbReference type="STRING" id="1459636.NTE_03235"/>
    <dbReference type="GeneID" id="41598890"/>
    <dbReference type="KEGG" id="nev:NTE_03235"/>
    <dbReference type="HOGENOM" id="CLU_1850535_0_0_2"/>
    <dbReference type="OrthoDB" id="377281at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="138" mass="15328" checksum="4DF1172A530AAB8B" modified="2014-10-29" version="1">MAKLTIHRKGHTRKAYTAKRGGKTVKVGKSRVKPSTFKARDRGKKGRGPKIVPPLEEGALGGSGFFNRTNDEQERIVFERAKELGEKKVVGELRALQVFFKTTDPQKSKRALELSKKVAGSFKGKQKVEYPEGFGKSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N1F5</accession>
    <name>A0A075N1F5_9ARCH</name>
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        <submittedName>
            <fullName evidence="7">ATP synthase subunit C</fullName>
            <ecNumber evidence="7">3.6.3.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NTE_03275</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.3.14" evidence="7"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987052.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N1F5"/>
    <dbReference type="STRING" id="1459636.NTE_03275"/>
    <dbReference type="GeneID" id="41598930"/>
    <dbReference type="KEGG" id="nev:NTE_03275"/>
    <dbReference type="eggNOG" id="arCOG02455">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148047_3_2_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033177">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, proton-transporting domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18120">
        <property type="entry name" value="ATP-synt_Vo_Ao_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.20.10">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038662">
        <property type="entry name" value="ATP_synth_F0_csu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="6">
        <location>
            <begin position="51"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF85304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="113" mass="11177" checksum="63C95459B7F6DE2F" modified="2014-10-29" version="1">MMQLKVRGALSLLTILAAVVFAGIAFASPAAYAQEAGGAAAATSSSAFKFLAAGIAFGLAALGAGFGLGFVGAAGLAAISENPKMQSSVFIIVGMVESIAIYGIVMMFIILGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLJ8</accession>
    <name>A0A075MLJ8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Kef-type K+ transport system, predicted NAD-binding component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NTE_00059</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987081.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLJ8"/>
    <dbReference type="STRING" id="1459636.NTE_00059"/>
    <dbReference type="GeneID" id="41596010"/>
    <dbReference type="KEGG" id="nev:NTE_00059"/>
    <dbReference type="eggNOG" id="arCOG01955">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005126_1_2_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42751">
        <property type="entry name" value="SODIUM/HYDROGEN EXCHANGER FAMILY/TRKA DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42751:SF3">
        <property type="entry name" value="SODIUM_GLUTAMATE SYMPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="243"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="9">
        <location>
            <begin position="37"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="410"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="416"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="428"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIF82143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="437" mass="46137" checksum="8AD88204B77553D8" modified="2014-10-29" version="1">MNQTAATTIGTTIFPQFFAPGNGPTDFIVQDFAVVMVVAAIMIAITYKLKQPMVIGYILAGILIGPYTPPFSLVRDASTINVLAELGIIMLLFVVGTEFPMAKLRSVGRVSFVVAVAETLGTLFLVFFIAQYLGFAFFDSLFLGLALSITSTVVTVRILEELGMIKDKSSILLLGITVVEDILAISILAILQSVAANGGQVEPLNLAISIGIVAAFIGGVLFLGSRLFPKIVDRAGRTNDYALLLIVILGLAFGLSFIANGIGLSVATGAFLAGVLVAESNSAAVARILTLPLRDMFAAIFFVSIGALMDIRVLPDYILPAAILILTSFGAKFLIVTGILTKAKYDSVTALRTGFGMSAAKGELSLVVVKGGQDVGAISSTILPLLGVVTIVTTFMAPYIIRFGSKIRVQSSTSSTDDDNNDDDDDDDRKPEEEKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLS1</accession>
    <name>A0A075MLS1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00364</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699421.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLS1"/>
    <dbReference type="GeneID" id="41596256"/>
    <dbReference type="KEGG" id="nev:NTE_00364"/>
    <dbReference type="HOGENOM" id="CLU_2765843_0_0_2"/>
    <dbReference type="OrthoDB" id="381866at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="69" mass="7960" checksum="6C0387D21745E878" modified="2014-10-29" version="1">MDKFTEKLVQNALSTYIPKLKEMSASRADELASMKAKVRANPDEVEAWFDKEIDRTRNQLNDALKKIMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLV2</accession>
    <name>A0A075MLV2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00399</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699443.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLV2"/>
    <dbReference type="GeneID" id="41596280"/>
    <dbReference type="KEGG" id="nev:NTE_00399"/>
    <dbReference type="eggNOG" id="arCOG12810">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025660_0_0_2"/>
    <dbReference type="OrthoDB" id="378516at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="534"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="583"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="600"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="645"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="705" mass="76587" checksum="9E860B206C01ABC3" modified="2014-10-29" version="1">MNLYSDARKVAVEYTLVAGVLLLLIVGYAAYPLIGAAQAATSESLTINAFSLPDGDAVSVLVEIRAGGNLIKSGFAPLTIAAQAGTIYTIKVSNSQSYAFDHWQDGSKSNTKAILLSEDTTLAAFFKKVSMPPNLTVNAMTPNGEELHMWTTVRSGLQTVGSGLTPFTFSGAPGRTYQLTVGNQEAESASLGEGAASLSGPAPISIIFNHWQDNNDRSRTRDITLPADGSSLNLLGVYNKGDRVTLEDLGVLQLVSHDLYNTIRDGPNPGSIEDERLNLSTLLDHGEDQIILGGEPRNSENIALHTVAVKLGKMYLDLVIDKKMSPEAARAQTVQVYLQMVAKAYEDTFHEPFPDAAPSEHEVQENGEENLTGDLSLRAIHSYVPGHIMVNGVDTMILDPSLRGKTLSDEDMQQLSKPLDGTFDPVFRNVTIFLPPPNPPPNLFTIDLFERDSSFAKQFGTDVSFEEFMGELKDGRFDENEKVMFYLREDIANGLMPPEEEGEQEGGDDNAAVAAQEAIAGNATAAVSNTTAVASGSTAGGSMLQPPPITAAASTPAAHNGTGTVQEEKPTQATQNSNNGNDDNNDSNDDEQEQADDDNSGEKEEKHWSASDGDRNEHNDDDDEERDSNKGDDNNNGGGDEHEEGDGNGRDDRHDHQHDNNNNDDDDRRNRQSERHNDDDDEDGSRWSRHHHLLEDTIEKIIQQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLX0</accession>
    <name>A0A075MLX0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00151</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLX0"/>
    <dbReference type="KEGG" id="nev:NTE_00151"/>
    <dbReference type="HOGENOM" id="CLU_2645691_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="76" mass="8674" checksum="5D0045E5D640B261" modified="2014-10-29" version="1">MNFAFASIVLFFSRPRVFRSVDLVVFMSSFMQAIGASARLKLLKRGRGRMDNFRRDPVCLRTPGVAGHNDTIRVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLY6</accession>
    <name>A0A075MLY6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_00171</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699280.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLY6"/>
    <dbReference type="STRING" id="1459636.NTE_00171"/>
    <dbReference type="GeneID" id="41596102"/>
    <dbReference type="KEGG" id="nev:NTE_00171"/>
    <dbReference type="eggNOG" id="arCOG02391">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1105170_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050595">
        <property type="entry name" value="Bact_response_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041226">
        <property type="entry name" value="NitrOD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44591">
        <property type="entry name" value="STRESS RESPONSE REGULATOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44591:SF21">
        <property type="entry name" value="TWO-COMPONENT RESPONSE REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18550">
        <property type="entry name" value="NitrOD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="116"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF82253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="251" mass="28222" checksum="B875135EFED4D134" modified="2014-10-29" version="1">MQNIDSYRLAETILSTIESVFGPRVFDAFIEKISEDYLGGEMSVHAAIMQRPELFELAFIGILGSRTGGEILAKICERTKSELGLDDAVTTSYSKKGDFAKFVAATTTAGSQVGTIIMIVDDDKDILSGIEKSLIACGYNKVQTFNDPVKALEHFKSAYDNNNEKEEKRDYYHHNHVLVLTDIRMHGMDGLRLAEELLRINPDAKIMPMSAYQLDEKMKNHLRRVTRENLLQKPFGMKELCVAVRNATRAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MM04</accession>
    <name>A0A075MM04_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00191</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MM04"/>
    <dbReference type="KEGG" id="nev:NTE_00191"/>
    <dbReference type="HOGENOM" id="CLU_3162924_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="47" mass="5377" checksum="646BF984BBCD66C0" modified="2014-10-29" version="1">MTCPIMVGVPEGLLLLQFDHTYINQLVEDTSSQLAKLITIRIKPHWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MM90</accession>
    <name>A0A075MM90_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UvrD-like helicase C-terminal domain/AAA domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_00296</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699374.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MM90"/>
    <dbReference type="STRING" id="1459636.NTE_00296"/>
    <dbReference type="GeneID" id="41596202"/>
    <dbReference type="KEGG" id="nev:NTE_00296"/>
    <dbReference type="eggNOG" id="arCOG01951">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006651_0_0_2"/>
    <dbReference type="OrthoDB" id="45637at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050534">
        <property type="entry name" value="Coronavir_polyprotein_1ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027785">
        <property type="entry name" value="UvrD-like_helicase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788:SF6">
        <property type="entry name" value="DNA HELICASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13245">
        <property type="entry name" value="AAA_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13538">
        <property type="entry name" value="UvrD_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="3">
        <location>
            <begin position="621"/>
            <end position="819"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF82378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="1244" mass="143998" checksum="445F9C8F4720E5CA" modified="2014-10-29" version="1">MKHVTVRFAWHDNKWNGRICVDPTGNFYCRDNYSLISPRIQKRINLDLEGRLKERPVSDALKSANYIPPCYWSINALGEKDYPITDPHPFQDLKRMSEKFSKQAPPLKSTLRHNSVFTWCFKLGFGEDRSEQLYVPTSELKKRVDVYTGEISKEKSIAFFYANYSNPLTGDDYRYVLLGAGLVEGLEKPIEYSIPQSLLQELRSGDRMQNFPTSSWQFQINLKPETTFIMPYHEYLRWTEDAQGTQRSERWKKLEEIVIPINEGNVIPHFKYVSMHVNHDKAIFLLYLFKRSLRKMKEHGEIVPYSEMEKIEFVVDRLLNIAWKERSKYPGFENSLHSILKTDFAPEKLKDTISAVRSFILKKTGSLDKFFSSTTRLTAEEPAIAKALREIEVNKELLRFLSIFDFSTIQFSNVKEIINKIGFQTIKKNPYLLLEKYHFDGEDSWNIDEADYGINLYQIDMALIPDLDYADWETPYSAQSPERIRAVITKILYDVAREGSSCLTREEIIGSIKNYPLFYIADELNIDVDKLIEYEKQPIFKEKFVIKDESFQGGPVLYQLKQLRTVEDALEQFFKKMMTKKHTLSSSDQSWIDNIVRLEKQGAGDKLNSNERQVLYRNALENGLFILSGKAGSGKTTAVVNLIQRFRELGNTPIFVFTPTGKANIVIRDRLKPHGLTDDNRIKILTIHRFLYSAIFDAIRNYQTQNKYSSYNRYNEYRPNSNIGQQASMMVDLISKILSGKLEVLDDFMEMSKGFRFSPQVVIIDEASMIDEVLLSALFAMINADNLKHLIVVGDEKQLPPIGAGRPFVDTIFQLKRTGMESNYIRLESNLRFDTTARIGFLAEIFGGNKSPHPHEIADALAKNDSTLEIHYFSSDHELKESVRKVLNSIGKPKAGALSDMFGDIYEDSSKPVLDRIQIITPRRVGSFGSMFINTNVVKEGAQEFSPRTKLICEENKYVYVKKDGRYKRVLALANGSVGYIMPDGSVSFEDLDDFQRDFEWSYDIENIKREVRDDYIGIERTINFGYAITVHKAQGSDYEHVILVIPEMSPFIMRELLYTAFTRIRTKLHLMIHNSLKDELALIFAKAYENSSVEQRRTLLFGHKSSPYRPYLLTLKNGMTIEVRNKIEQIIGRTLDNFCERLEYEPRDFLQEYRVLPDFKFEIDGIAYYLEHLGHMDNRSYRNRWIQKLGIYEKVGIGDNLITTTESDQASDTEQNIFQIVSDIKANSLKVTSGSHSKHHYVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMB6</accession>
    <name>A0A075MMB6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699296.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMB6"/>
    <dbReference type="STRING" id="1459636.NTE_00193"/>
    <dbReference type="GeneID" id="41596118"/>
    <dbReference type="KEGG" id="nev:NTE_00193"/>
    <dbReference type="HOGENOM" id="CLU_1736336_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="150" mass="17115" checksum="9C91356D26AE6BE3" modified="2014-10-29" version="1">MAFAIYHTKDSSQGVRRSSNNEGPFRQKAEKDGKTFRFKTGDSKEILKGARIVYKGAKLMDTAKAGSQMIFVLDISKDVAVDSLAAYLFARFKNHSDDIVGIRIEENLVRVSEESLARAFLKEIKRSENEERKAQDGKLTRFYNRKREVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMD8</accession>
    <name>A0A075MMD8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00336</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699400.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMD8"/>
    <dbReference type="STRING" id="1459636.NTE_00336"/>
    <dbReference type="GeneID" id="41596232"/>
    <dbReference type="KEGG" id="nev:NTE_00336"/>
    <dbReference type="HOGENOM" id="CLU_2597525_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="79" mass="8758" checksum="FB3873F125A70DA7" modified="2014-10-29" version="1">MGDIDLKQSITGRELKRAIEKAFAILGYSGVDALLSDLEGHGIALNSDKQYQLDEINVIFENLFGPVSNLMINKILHEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMG2</accession>
    <name>A0A075MMG2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NTE_00580</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385029.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMG2"/>
    <dbReference type="STRING" id="1459636.NTE_00580"/>
    <dbReference type="GeneID" id="41596445"/>
    <dbReference type="KEGG" id="nev:NTE_00580"/>
    <dbReference type="eggNOG" id="arCOG03682">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_44_2"/>
    <dbReference type="OrthoDB" id="41005at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd14014">
        <property type="entry name" value="STKc_PknB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050660">
        <property type="entry name" value="NEK_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671:SF13">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000654">
        <property type="entry name" value="Integrin-linked_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="3"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF82661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="273" mass="31644" checksum="9EF099B1EE7A1A58" modified="2014-10-29" version="1">MQYRIIKRLGSGGFGNVYQVEGSDGNTYAMKLLKSVDVVNKKRFEREIKILATLDHPNVVRIYQWNLGGDPPDFSPWYVMEYLRGGSLREHMDEKFRNRYVFQRNRSINSIILPVCNALAQAHSLSIYHRDLKPDNIMYIDDYRTAIKITDWGLGRDINKKSLMLTAEIGHVGGDPGYCAPEQWFATENPDGRADIFSMGVMLYELMTGRRPAHYDNQMRRPAIEPPSKFHPSISPQMDRLILKMLSLHPEERPQSVWELMSEIENLPDAKYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MML7</accession>
    <name>A0A075MML7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 13 14">Ribonuclease HII</fullName>
            <shortName evidence="13">RNase HII</shortName>
            <ecNumber evidence="6 13">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">rnhB</name>
        <name evidence="18" type="ORF">NTE_00626</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 13 16">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13 15 16">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 15">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="13 15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13 15">Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 13 16">Belongs to the RNase HII family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="6 13"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987133.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MML7"/>
    <dbReference type="STRING" id="1459636.NTE_00626"/>
    <dbReference type="GeneID" id="41596489"/>
    <dbReference type="KEGG" id="nev:NTE_00626"/>
    <dbReference type="eggNOG" id="arCOG04121">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036532_0_4_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07180">
        <property type="entry name" value="RNase_HII_archaea_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.460">
        <property type="entry name" value="Ribonuclease hii. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00052_A">
        <property type="entry name" value="RNase_HII_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004649">
        <property type="entry name" value="RNase_H2_suA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001352">
        <property type="entry name" value="RNase_HII/HIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024567">
        <property type="entry name" value="RNase_HII/HIII_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020787">
        <property type="entry name" value="RNase_HII_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023160">
        <property type="entry name" value="RNase_HII_hlx-loop-hlx_cap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00729">
        <property type="entry name" value="ribonuclease HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954:SF23">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01351">
        <property type="entry name" value="RNase_HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51975">
        <property type="entry name" value="RNASE_H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 13 15" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="12 13 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="10 13 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13 15" id="KW-0540">Nuclease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-2" evidence="17">
        <location>
            <begin position="2"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13 15">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 15">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 15">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00019179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="NCBIfam" id="TIGR00729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="AIF82706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="216" mass="24679" checksum="716A1880460BFBBD" modified="2014-10-29" version="1">MLLIGGVDEAGRGSIIGPLVVAGVSVRESKITKLKEMGVRDSKQLTRQAREKLYDEIISIADHYHIHTIKSTEVDSHVLQRGLNKLEARAMAHVIGKMKVDEVYVDCCDTNPERYREHIACHLKSATQVIHSMHHADRINVVVSAASILAKITRDFEIQKIRKRYRDIGSGYPSDEKTMLFIRNWVEMKKTPPAFARKSWKPLRTMLEGMEQRTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMN2</accession>
    <name>A0A075MMN2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zinc-ribbon domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00318</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMN2"/>
    <dbReference type="STRING" id="1459636.NTE_00318"/>
    <dbReference type="GeneID" id="41596221"/>
    <dbReference type="KEGG" id="nev:NTE_00318"/>
    <dbReference type="HOGENOM" id="CLU_1987508_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="125" mass="14111" checksum="27A5DC77789F45CC" modified="2014-10-29" version="1">MSKDVLLVLNDLLKKNVVSSDLLPDIISRYSELKASFDKNPYGEALKQVMNSVDRSFMSEEEMIPSSQILLLGVAINLVKMEKAQQSQRIDFFSFLPNAGMKKCSKCNVLNIQNARFCYSCGEHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMX1</accession>
    <name>A0A075MMX1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00537</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMX1"/>
    <dbReference type="KEGG" id="nev:NTE_00537"/>
    <dbReference type="HOGENOM" id="CLU_3371265_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="34" mass="4023" checksum="E75717855047D8BF" modified="2014-10-29" version="1">MMYLLDRIRKSTEKVKSDVCEIDVLEFSEGVMTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MN23</accession>
    <name>A0A075MN23_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bacterial Ig domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00577</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699585.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MN23"/>
    <dbReference type="STRING" id="1459636.NTE_00577"/>
    <dbReference type="GeneID" id="41596443"/>
    <dbReference type="KEGG" id="nev:NTE_00577"/>
    <dbReference type="HOGENOM" id="CLU_126923_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17957">
        <property type="entry name" value="Big_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="171" mass="18282" checksum="F76D46BEBDC35E99" modified="2014-10-29" version="1">MYRKTILEKKKRNHHYYYHLLAGLAAVIVAAVTVMGIEDFLSFGSFAVAEGIPSAAAQEAAKDTTKPTGTITSPASGDVVKLNTPITVNGTASDNVKVSKVEVRAVNAEDILGTRYAPATSTDGYASWTFSLTIPNTDYENITVRITDTSGNQKWMTHRVSIAAEAAEGPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MN35</accession>
    <name>A0A075MN35_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00479</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MN35"/>
    <dbReference type="KEGG" id="nev:NTE_00479"/>
    <dbReference type="HOGENOM" id="CLU_1222474_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="226" mass="24651" checksum="90FC8958021BBAA2" modified="2014-10-29" version="1">MQRLHLLSALAGAVLFFIAFAVVVYLPSSSSLPSYSQKDYEIKVESTSDSDKGFYGVNEGAIITSKVTLENSGRKPLADVQIKYMSTVRCEQHIQLDDNDVPDSLRSDLTKAIRYDEEGGSELVSSFIQEHKNQIDGIGLVYPEDERGGNGEPDLFFYKIVEKERLIDRETIKAINPAERISLSPPSGAQYVVVDANYPGVSGMAAKIQGAPGAQEVLADAAKDCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MN39</accession>
    <name>A0A075MN39_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative ring-cleavage extradiol dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_00592</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699596.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MN39"/>
    <dbReference type="STRING" id="1459636.NTE_00592"/>
    <dbReference type="GeneID" id="41596455"/>
    <dbReference type="KEGG" id="nev:NTE_00592"/>
    <dbReference type="eggNOG" id="arCOG06106">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059557_0_0_2"/>
    <dbReference type="OrthoDB" id="37941at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004462">
        <property type="term" value="F:lactoylglutathione lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018146">
        <property type="entry name" value="Glyoxalase_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43279">
        <property type="entry name" value="CATECHOL-2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43279:SF1">
        <property type="entry name" value="CATECHOL-2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00934">
        <property type="entry name" value="GLYOXALASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="16"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="184"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF82673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="301" mass="32993" checksum="41BC8D9A5D387E71" modified="2014-10-29" version="1">MATTAGGRFVAHPSSKIGYVSLNVSDISQSLEFYESVLGFKVLGRQSSAGDRALLSVDNNTAHLLELRKAAKKEGAEQQKRAGLYHFAILLPERKFLADALAFLGRETRGQVHFDGMADHSVSESVYIRDPDFNGIEIYRDRSRSEWQVTSSRQIKMVTERLDTEGLLAQATAAGWKGMPAGTTIGHVHLHVRDLGRAMQFYSQILGLGLTFTFPGAYFFAAGGYHHHVATNTWLGQNISAAALPEEAVVGLNHFAIKVPDEKEELGRAASNLLRHGVLVSQEQNSATGRDPDGITVKLYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNA5</accession>
    <name>A0A075MNA5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00956</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNA5"/>
    <dbReference type="STRING" id="1459636.NTE_00956"/>
    <dbReference type="KEGG" id="nev:NTE_00956"/>
    <dbReference type="HOGENOM" id="CLU_3112874_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="50" mass="5702" checksum="BF5037DB695F9633" modified="2014-10-29" version="1">MQTMPIKPLLKLKVHGSTSEAAVITKPKTLNAIWQTKYAVSRVKWPFYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNB7</accession>
    <name>A0A075MNB7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cysteine-rich secretory protein family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_00569</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699576.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNB7"/>
    <dbReference type="STRING" id="1459636.NTE_00569"/>
    <dbReference type="GeneID" id="41596434"/>
    <dbReference type="KEGG" id="nev:NTE_00569"/>
    <dbReference type="eggNOG" id="arCOG03962">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061942_0_0_2"/>
    <dbReference type="OrthoDB" id="43989at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd05379">
        <property type="entry name" value="CAP_bacterial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31157">
        <property type="entry name" value="SCP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31157:SF1">
        <property type="entry name" value="SCP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="90"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF82650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="405" mass="44743" checksum="9A96BF14A1D52365" modified="2014-10-29" version="1">MSFLDKKKRYVCGNSNDPTKAAALAILTVALLLMATMMSPALGRLVQSAAAVELTAATDADDDDDGDNRSGTSGDNEDNNNNSELKQYALQRINEDRAKFGIAPVSMGDNMAAQVHAKDVLKTRMISHWTTDGEKPYMTYSRLGGEGAVAQNVATSGYPQDYDGCVSGTLLCEKTDPRKAIDQVEYNMMDKDKECCDDGHRNNILDKHHTHVSIGIAYDDYFFVMVQNFEDKYTVWTHRISEEQEETDANNNDDDDSDDNSGQQQQMEMITMSGSLVDNRGDSSTDNNNDDGDGGLSLVNVQVYYDSLPTPEIYEQHRYDKSYGLGKLIALVAEPAPEGTAYKQPDKFSIIEAQNWQAQGSEFDIAFSLQELSDTYGKGVYTIVMLAQNSEDEVLPTSETSVFVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNN9</accession>
    <name>A0A075MNN9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_193354086.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNN9"/>
    <dbReference type="STRING" id="1459636.NTE_00660"/>
    <dbReference type="GeneID" id="59387785"/>
    <dbReference type="KEGG" id="nev:NTE_00660"/>
    <dbReference type="eggNOG" id="arCOG08687">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_202920_0_0_2"/>
    <dbReference type="OrthoDB" id="6591at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="55" mass="6567" checksum="A77C14769AA5BFCC" modified="2014-10-29" version="1">MKVRCPDCKAIAELADDFSYVKCTECEFDMTYGEYVKYIAYKDARYRDILSDYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNP9</accession>
    <name>A0A075MNP9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protocadherin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_01103</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNP9"/>
    <dbReference type="STRING" id="1459636.NTE_01103"/>
    <dbReference type="KEGG" id="nev:NTE_01103"/>
    <dbReference type="eggNOG" id="arCOG02080">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_459777_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35902:SF3">
        <property type="entry name" value="NPCBM-ASSOCIATED, NEW3 DOMAIN OF ALPHA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35902">
        <property type="entry name" value="S-LAYER DOMAIN-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="523"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="552"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="554"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="583"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF83176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="593" mass="61348" checksum="EF04B9B7DA9F4133" modified="2014-10-29" version="1">MAAAIVVAAALVVSTPLGALAQLSEADIINANISGPVFLDAFWTDRTTMPPAGTPLSKVEVAPGDGSSILAVTLVNRGFSDITSVSGTLSLPSGFTSSSRSSEAVATYNGIVTAGNTFTLFFQVNVSDNASIQSYSSGLKVEYSRTLESGAPRTADINVPFKLTGKVILDASSEGGVAPGTSGRVAIKITNTGSAPATGVVVTVPGSSGVNPTTQQASLVAVGQKSFEIGTITPGNSTTIEPVLYASNSAGETLQTVPLQIEYGNTYGEKKNSTVPVGLIILPTSSSSPLSATPVGNSSIMTAGKITDLRVSLANNGNQQLSDIVASISSTAEQIKILGKTSWTVGDLAPGASQEISTQVYSSTDMIGKAATFKLTVQRISAGQPEIETFDIGTYVDGEISVKAYEIGVTYIGGVPNITGNLLNEGNVLALFTTVEVTSAHGLANSLPPQQYLGDLQENSPLPFSIPIDVANNTGAGTYPVELKVQYKDSLREQHTLDIKANVDFKPEAPAQNTQQSQAGSTMMIGVIAGIIAAVVIAVVVIRMRKKSKLKHTLQFSKQQNGDGSGSNDDIESVLDSHLGSGSKKEEKERAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNZ1</accession>
    <name>A0A075MNZ1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01168</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700038.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNZ1"/>
    <dbReference type="GeneID" id="41596980"/>
    <dbReference type="KEGG" id="nev:NTE_01168"/>
    <dbReference type="HOGENOM" id="CLU_1821080_0_0_2"/>
    <dbReference type="OrthoDB" id="374696at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="143" mass="16301" checksum="2E9F0E306A18B22C" modified="2014-10-29" version="1">MAEKKEAQSYLTNYGYKTINLLASTVDTLKAEFQAFQKEIGEVYGNPLISDYLDLLVKLYINRHNLPRLMLVSKGPGRVVMYDTRAQVPIAISLDKKGNLSCTRVQALDEYVRFAKKYAPELFATYERTKARKTRGQGRSKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNZ9</accession>
    <name>A0A075MNZ9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ketosteroid isomerase-like enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00802</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699761.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNZ9"/>
    <dbReference type="STRING" id="1459636.NTE_00802"/>
    <dbReference type="GeneID" id="41596651"/>
    <dbReference type="KEGG" id="nev:NTE_00802"/>
    <dbReference type="HOGENOM" id="CLU_137417_3_0_2"/>
    <dbReference type="OrthoDB" id="9698at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="14"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="124" mass="13052" checksum="A365E97580E23108" modified="2014-10-29" version="1">MHSGTPEEVLKSIVDGINTGNLDALVPLYEPNAAFAAQPGNLAHGLAGVREALTGFIAMKGKLDLKVTRVLEANGLALVIGVWSFTGTGPDGKPVKLASKSADVLRRQADGSWRFVIDNPWGTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MP48</accession>
    <name>A0A075MP48_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700092.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MP48"/>
    <dbReference type="STRING" id="1459636.NTE_01230"/>
    <dbReference type="GeneID" id="41597038"/>
    <dbReference type="KEGG" id="nev:NTE_01230"/>
    <dbReference type="eggNOG" id="arCOG08637">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1514543_0_0_2"/>
    <dbReference type="OrthoDB" id="4898at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="167" mass="18235" checksum="3C77AE9C6FD2D57F" modified="2014-10-29" version="1">MVNKFVFVIAGIVIVMAVLIALPSVSQQPAAQDVTIEYNRQHLTKTGGLLVATQLETLTIDKDGSGTYTKTDPREKNMPVPQRFSLSREEFAKIKGLVLETGFMDVPKTDYPQSENASNFASYTLAVKTADKQKTISWVEPDAYDGTIPPLITNVGNQLDGIIASKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPE3</accession>
    <name>A0A075MPE3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPE3"/>
    <dbReference type="KEGG" id="nev:NTE_01009"/>
    <dbReference type="HOGENOM" id="CLU_3379971_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="34" mass="3523" checksum="268B2DC169135C68" modified="2014-10-29" version="1">MMTPTKKKFALAAAGGAAIIIFAIIKLIFTLNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPG7</accession>
    <name>A0A075MPG7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NTP pyrophosphohydrolase</fullName>
            <ecNumber evidence="4">3.6.1.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_01034</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="3.6.1.13" evidence="4"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385100.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPG7"/>
    <dbReference type="STRING" id="1459636.NTE_01034"/>
    <dbReference type="GeneID" id="41596857"/>
    <dbReference type="KEGG" id="nev:NTE_01034"/>
    <dbReference type="eggNOG" id="arCOG01073">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062658_5_2_2"/>
    <dbReference type="OrthoDB" id="104705at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047631">
        <property type="term" value="F:ADP-ribose diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006753">
        <property type="term" value="P:nucleoside phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019693">
        <property type="term" value="P:ribose phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03424">
        <property type="entry name" value="NUDIX_ADPRase_Nudt5_UGPPase_Nudt14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839:SF18">
        <property type="entry name" value="NUDIX HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839">
        <property type="entry name" value="UDP/ADP-SUGAR PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="39"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF83108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="181" mass="20142" checksum="5B714C72A84F738E" modified="2014-10-29" version="1">MPDIIRVIASRRVYAGAISLRKDKFSVNGGRVVEKEIVEHQPSVGIIAAVDNDSIILVSQYRRAPDRTLLEIPAGKIEQGETPRQAAVREMDEEIGYTGKLKPFLKWYLAPGYDTELMHLFVATDLKKIDNTRRATMDDDEDIVAKKVKLAAAVKKCLNGEIQDAKTIAAIMAYASFLKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPM8</accession>
    <name>A0A075MPM8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00707</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699689.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPM8"/>
    <dbReference type="STRING" id="1459636.NTE_00707"/>
    <dbReference type="GeneID" id="41596562"/>
    <dbReference type="KEGG" id="nev:NTE_00707"/>
    <dbReference type="eggNOG" id="arCOG04936">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_907937_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00761">
        <property type="entry name" value="Glyco_tranf_GTA_type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="1">
        <location>
            <begin position="27"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="306" mass="35583" checksum="D8079836B03EC4F9" modified="2014-10-29" version="1">MYQQEQRSDSGSQSQSYYAIVFGRDGNKSIRKVLDSLLAQTVMPARIMIIDDGSTDGMYQTVLEYEQKFPHIVHVRQTSNKTRDYTRLPLLWNMGILPDYDYHVIVPSDASFVPNYAERILLEFTRNPDLVVCSGDWGPMNAKAPHGGGRFVKQSFFFKHYPQGYPHILGYESEILERALMGKPGSIKVLNDLEIFHHDALGHSHNFKEFGYGMKCLGYYPPYAIFRIGWDFLTNKTVGKRGALKILRYYVLFRPADTGYYSKFPEDIRRQVRARQKKMLKKMLRQAVQKIWRQINKDRTGVETEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPY5</accession>
    <name>A0A075MPY5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator with CheY-like receiver, AAA-type ATPase, and DNA-binding domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_00851</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699797.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPY5"/>
    <dbReference type="STRING" id="1459636.NTE_00851"/>
    <dbReference type="GeneID" id="41596694"/>
    <dbReference type="KEGG" id="nev:NTE_00851"/>
    <dbReference type="eggNOG" id="arCOG02595">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_17_2"/>
    <dbReference type="OrthoDB" id="9652at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00156">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050595">
        <property type="entry name" value="Bact_response_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44591:SF3">
        <property type="entry name" value="RESPONSE REGULATORY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44591">
        <property type="entry name" value="STRESS RESPONSE REGULATOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="2"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF82927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="128" mass="14020" checksum="A32132AC6BFA0746" modified="2014-10-29" version="1">MRILIIDDSHDITDLLVKVLTTVGHEVASSDNGKEGLVMINDGKFDLVFLDIAMPDFSGLDVIDKLVQSGRIRDSPIVLFTASSITDAEVAELVKKGVHSCLRKPVRIENLFEKVEEIGKLRASTAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQA1</accession>
    <name>A0A075MQA1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01177</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385140.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQA1"/>
    <dbReference type="STRING" id="1459636.NTE_01177"/>
    <dbReference type="GeneID" id="41596988"/>
    <dbReference type="KEGG" id="nev:NTE_01177"/>
    <dbReference type="HOGENOM" id="CLU_1080102_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="257" mass="27720" checksum="39E8235D17839CDA" modified="2014-10-29" version="1">MSLNYKLITLFVLIAIMLLAVQMQSAFATTNPNKRSDRQMHGVLTWGNKGTVAKATSTLTDQANVSWAKAFTGEFILTWDSFGNGVVGAGWLHYKDNSNNIHNSMASYYYDVFHGTTGLGFAGEEGGSAFSALTLRGTFDSINNCRNWSITLGTSYSENRCISSFDSGLGEVWSISNSGSNTFLSGTEYAGLQYYPATGGGAANWSSSSASEYCWDDSPFVTNLVTDRNNWNVSPPGSGTACDLDARQFTSAKPILP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQB6</accession>
    <name>A0A075MQB6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_01325</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385163.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQB6"/>
    <dbReference type="GeneID" id="41597125"/>
    <dbReference type="KEGG" id="nev:NTE_01325"/>
    <dbReference type="HOGENOM" id="CLU_1665408_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043200">
        <property type="term" value="P:response to amino acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30154">
        <property type="entry name" value="LEUCINE-RESPONSIVE REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30154:SF34">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR AZLB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF83393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="149" mass="16776" checksum="738DBF979F670C6F" modified="2014-10-29" version="1">MDKDLLKILLTPNGRISSKAIADKLGVPATTVQRRRRKLEDDLLTITYSLDLKRFGWHRVDFLIATEKGRTIAIAKQLSKLDEVVYVGRSIGQQTIDLHVQAILEGNADILRIMEQLKSMPGIKDVVWSEIVQVVGKKPSVPLHIIDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQD0</accession>
    <name>A0A075MQD0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01208</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700072.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQD0"/>
    <dbReference type="GeneID" id="41597017"/>
    <dbReference type="KEGG" id="nev:NTE_01208"/>
    <dbReference type="HOGENOM" id="CLU_2447519_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="89" mass="10537" checksum="06E7EFDE5493C8C7" modified="2014-10-29" version="1">MSIEERISKHLKMYERDLSENHNPIIIMTNEAKVRILKTAPRDLNKLNVEIALKTKAYNNETKFPEREILRVELHALEWLRLTVRIEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQF2</accession>
    <name>A0A075MQF2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01033</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQF2"/>
    <dbReference type="STRING" id="1459636.NTE_01033"/>
    <dbReference type="KEGG" id="nev:NTE_01033"/>
    <dbReference type="eggNOG" id="arCOG03681">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_153630_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="139" mass="14972" checksum="CF34E006489471BE" modified="2014-10-29" version="1">MPVEFVDPDGNIIIPKAIRPIIDIEETVLGSKRGAKKQYRYGNLHIREYDSHYTVHMDRVDPRKDPLGHLLADAPEYIAGAAAAAYVGRKVGRAVYEKRKKDGKGARDAAVDALVAGLFAGSSAGKLAFAAANAAKKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQJ7</accession>
    <name>A0A075MQJ7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQJ7"/>
    <dbReference type="STRING" id="1459636.NTE_01745"/>
    <dbReference type="KEGG" id="nev:NTE_01745"/>
    <dbReference type="HOGENOM" id="CLU_2406205_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="92" mass="10220" checksum="4028CFE085AA10A1" modified="2014-10-29" version="1">MCQVKVLIAFVMETGIQIGLDCRFYNEIVDSARDNIVKYSISMGPSHYAMEKVRKPTMVRAANGTMNHATAELPDRLTWGKGCVHASNTKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQV8</accession>
    <name>A0A075MQV8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein involved in propionate catabolism</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_01530</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PrpD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700337.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQV8"/>
    <dbReference type="STRING" id="1459636.NTE_01530"/>
    <dbReference type="GeneID" id="41597317"/>
    <dbReference type="KEGG" id="nev:NTE_01530"/>
    <dbReference type="eggNOG" id="arCOG04285">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026574_3_1_2"/>
    <dbReference type="OrthoDB" id="43639at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4100.10">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.120">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036148">
        <property type="entry name" value="MmgE/PrpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042183">
        <property type="entry name" value="MmgE/PrpD_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042188">
        <property type="entry name" value="MmgE/PrpD_sf_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005656">
        <property type="entry name" value="MmgE_PrpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045337">
        <property type="entry name" value="MmgE_PrpD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045336">
        <property type="entry name" value="MmgE_PrpD_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943:SF8">
        <property type="entry name" value="2-METHYLCITRATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943">
        <property type="entry name" value="2-METHYLCITRATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19305">
        <property type="entry name" value="MmgE_PrpD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03972">
        <property type="entry name" value="MmgE_PrpD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103378">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MmgE/PrpD N-terminal" evidence="2">
        <location>
            <begin position="25"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="MmgE/PrpD C-terminal" evidence="3">
        <location>
            <begin position="278"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF83593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="449" mass="49015" checksum="077FE122FDF3C3E2" modified="2014-10-29" version="1">MMMMVDNTLEKEDDNVAFKLAGIVVDDIRFGKLPAEVVSKAELFLLNGLGCLVAGRATEIGRGINFDESLTGKEKRWVETVKPTPEQYKMYRDASGTFSTELTTVCLAGINHPDSVVVPVLLNMGQKESSREAIVEALVAGTEVMAKIGILLNPSLYYKGWHSTGVCGIFGAAAVACKLLQKTKEETANAFQLAAGLASSDFYRLDKKYPVIKVANPGIASVAGVSAATQEQQKNCGAELKRTSVDDFVGTFRDGNNNSQSIDWTRYDILELFFKSMPVVCAFHAILEPLHDLLAKNQIDAADIAKIKVGYHKIPSDYYSGHTARSVYGAQTSLPYSVAILAKTHHAGIETFTKDVLKDKDVQRIADSVEIVPSERKGTDDLIAGEIELVLAGGEKYSGKVDKALGCSPKDVPAKFFQLARFGGLNEEAARRVYRKIADKEYDLEDLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQW2</accession>
    <name>A0A075MQW2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385227.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQW2"/>
    <dbReference type="STRING" id="1459636.NTE_01535"/>
    <dbReference type="GeneID" id="43502610"/>
    <dbReference type="KEGG" id="nev:NTE_01535"/>
    <dbReference type="HOGENOM" id="CLU_3093925_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="51" mass="5797" checksum="B17B072183C5494A" modified="2014-10-29" version="1">MHEYLSPLKPRYSECKWCGKRTAYSCIRCSYCYSCHPAIEYAEKAAKAGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MR04</accession>
    <name>A0A075MR04_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sugar kinase, ribokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_01922</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700645.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MR04"/>
    <dbReference type="STRING" id="1459636.NTE_01922"/>
    <dbReference type="GeneID" id="41597670"/>
    <dbReference type="KEGG" id="nev:NTE_01922"/>
    <dbReference type="eggNOG" id="arCOG00016">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_961782_0_0_2"/>
    <dbReference type="OrthoDB" id="26949at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050306">
        <property type="entry name" value="PfkB_Carbo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43085:SF57">
        <property type="entry name" value="CARBOHYDRATE KINASE PFKB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43085">
        <property type="entry name" value="HEXOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="4">
        <location>
            <begin position="34"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF83981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="307" mass="33718" checksum="806689D679B968BA" modified="2014-10-29" version="1">MKIGIASHIVLDTIKGSDGMVLESMGGPPCYCGITARRFGLDVELATSVGGDFPEEQRNFLRDNNITLKEDWHVARDAQTTRFRLEVEGDTRRLFLQTKCEPISERQVQDAKVDCWLVSPVIDEVPPSTLAAIKKNRGKKNFVMLDPQGYMRRTAAASDGSVISLIDKLDIDLAGITALKVDRQEMAALTGGAEGLEGMQALQAKGIEFVVATEHRVVHLLHKDMHYWIKLRDIDTSDSTGAGDILAAGFACGYVKEKDPLWAICFGAGALRAALETKEPGLAKIPPMNKIESSASYFYNTVSFKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MR46</accession>
    <name>A0A075MR46_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700079.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MR46"/>
    <dbReference type="STRING" id="1459636.NTE_01215"/>
    <dbReference type="GeneID" id="41597024"/>
    <dbReference type="KEGG" id="nev:NTE_01215"/>
    <dbReference type="HOGENOM" id="CLU_1954556_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="128" mass="15049" checksum="B924AB52F195BFEE" modified="2014-10-29" version="1">MMVSDFNTKRRIRSITAGDEIFTIVTTDDFETTISCDKTTPTGVVVRKIAERCDLYQIEYESLVEIRRLLDSATRAELKRKYKNYFEQKKIEVERIDIDIAAYRQEISRLTKLKEAIQKEIVMGVFWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MR69</accession>
    <name>A0A075MR69_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">4-hydroxybenzoate polyprenyltransferase-like prenyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NTE_01527</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700334.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MR69"/>
    <dbReference type="STRING" id="1459636.NTE_01527"/>
    <dbReference type="GeneID" id="41597314"/>
    <dbReference type="KEGG" id="nev:NTE_01527"/>
    <dbReference type="eggNOG" id="arCOG00476">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_862226_0_0_2"/>
    <dbReference type="OrthoDB" id="11851at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13956">
        <property type="entry name" value="PT_UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050475">
        <property type="entry name" value="Prenyltransferase_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42723">
        <property type="entry name" value="CHLOROPHYLL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42723:SF1">
        <property type="entry name" value="CHLOROPHYLL SYNTHASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF83590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="322" mass="34600" checksum="07D87E2115CAE4DC" modified="2014-10-29" version="1">MTLAGECNTHTTNKLTLKQGLLLLHSKKQPLGYATAGAVTYMFSSILAGSFSPFLNALVFGVLYAMYSAIYLYNDIVDLNIDKINSKDRLVASGKTTPRQAKKMVGFLFVIAALLTFLASSYFGPARGLQNYLTISVTVSASVFLGIIYSHPRIYLKKRFPFKSVSIASGAGLASLVGWAISSTDFTPSTLLSALSTSAVIFVMSILFDLRDLKGDRLHNVGTFPIVLGVDASRKMMYCNLAVPVLAAIITATLLGERVGPITLGILAAVSVIGIKALSRLGSNGLEDKKTFLNSVVTMRRLYYLTQLGMGSLAIGNMTTLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRE4</accession>
    <name>A0A075MRE4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zn-dependent hydrolase, glyoxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_01319</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700168.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRE4"/>
    <dbReference type="STRING" id="1459636.NTE_01319"/>
    <dbReference type="GeneID" id="41597121"/>
    <dbReference type="KEGG" id="nev:NTE_01319"/>
    <dbReference type="eggNOG" id="arCOG00517">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030571_7_3_2"/>
    <dbReference type="OrthoDB" id="197151at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050313">
        <property type="term" value="F:sulfur dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070813">
        <property type="term" value="P:hydrogen sulfide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07724">
        <property type="entry name" value="POD-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051682">
        <property type="entry name" value="Mito_Persulfide_Diox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044528">
        <property type="entry name" value="POD-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43084">
        <property type="entry name" value="PERSULFIDE DIOXYGENASE ETHE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43084:SF1">
        <property type="entry name" value="PERSULFIDE DIOXYGENASE ETHE1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="2">
        <location>
            <begin position="14"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF83387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="259" mass="28756" checksum="247D7913BCB61BB8" modified="2014-10-29" version="1">MALIFQQIRRMDSGCVTYLVGSTETKECAIVDPLLDADYVMEEAKKAGLKIAYVIDTHTHADHISGARAIAKKSRLPGVHMSEKSQGKFKTIIPVRDGQAIKLGQDVELKFVYTPGHTYDHVCVLVNNEKVLTGDTLFIGDVGRIDLGGDARDKSDKLFDSLHGKLMKLADGVEVYPTHVGAAHHLANAKMSSTIGAERENNGALKASDKDAFFKYMTEDWPPKPPDYQNIIRVNSSDDWLYGFVTNDLMKKWLAEDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRN1</accession>
    <name>A0A075MRN1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Glycerol-1-phosphate dehydrogenase [NAD(P)+]</fullName>
            <shortName evidence="11">G1P dehydrogenase</shortName>
            <shortName evidence="11">G1PDH</shortName>
            <ecNumber evidence="11">1.1.1.261</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Enantiomeric glycerophosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">sn-glycerol-1-phosphate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">egsA</name>
        <name evidence="15" type="ORF">NTE_01413</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>sn-glycerol 1-phosphate + NAD(+) = dihydroxyacetone phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21412"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57685"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.261"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>sn-glycerol 1-phosphate + NADP(+) = dihydroxyacetone phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21416"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57685"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.261"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11 12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Membrane lipid metabolism; glycerophospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the glycerol-1-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.261" evidence="11"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987209.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRN1"/>
    <dbReference type="STRING" id="1459636.NTE_01413"/>
    <dbReference type="GeneID" id="41597207"/>
    <dbReference type="KEGG" id="nev:NTE_01413"/>
    <dbReference type="eggNOG" id="arCOG00982">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038362_0_0_2"/>
    <dbReference type="UniPathway" id="UPA00940"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106357">
        <property type="term" value="F:glycerol-1-phosphate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106358">
        <property type="term" value="F:glycerol-1-phosphate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006650">
        <property type="term" value="P:glycerophospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08173">
        <property type="entry name" value="Gro1PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00497_A">
        <property type="entry name" value="G1P_dehydrogenase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023002">
        <property type="entry name" value="G1P_dehydrogenase_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032837">
        <property type="entry name" value="G1PDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016205">
        <property type="entry name" value="Glycerol_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002022">
        <property type="entry name" value="PRK00843.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43616">
        <property type="entry name" value="GLYCEROL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43616:SF5">
        <property type="entry name" value="GLYCEROL DEHYDROGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13685">
        <property type="entry name" value="Fe-ADH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000112">
        <property type="entry name" value="Glycerol_dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 11" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11 14" id="KW-0520">NAD</keyword>
    <keyword evidence="5 11" id="KW-0521">NADP</keyword>
    <keyword evidence="6 11 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 11" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="10 11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11 12" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="11 14">
        <location>
            <begin position="101"/>
            <end position="105"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 14">
        <location>
            <begin position="123"/>
            <end position="126"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>glycerol</name>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 14">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>glycerol</name>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>glycerol</name>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>glycerol</name>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000112-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000112-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000112-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AIF83477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="356" mass="38324" checksum="D146A78C986A1EB7" modified="2014-10-29" version="1">MVASPPSHLMELPRKILIGDRVIAEVGPFVRSLDVSARSVAVITGRVVKERAGVSCNSSLEDAMLRTKWHVVSDASMDTVNRLHDKIKDDRPDFVIGFGGGRSVDVAKMTAYRLSKPFLSVPTSASHDGISSPFVSVRGIDKPHSIKANTPIGVLADTHLLSQAPPRLLAGGCGDLVAKITAVKDWELARDEKGEYFGTYAANLAYMSAQIILEESEKLKKNERLGIRTVVEALISAGVAACIAGSSRPCSGAEHLFSHALEYVAGGAECGLHGERVGIGTIMMARLHGLDWENVRHTLEDMGAPTKAKQIGLTEDNVVQALVKAQSLRPDRYTILSKVKMDKKKARELAAATKVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRN4</accession>
    <name>A0A075MRN4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative xylanase/chitin deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01762</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700525.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRN4"/>
    <dbReference type="STRING" id="1459636.NTE_01762"/>
    <dbReference type="GeneID" id="41597532"/>
    <dbReference type="KEGG" id="nev:NTE_01762"/>
    <dbReference type="eggNOG" id="arCOG02876">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_958524_0_0_2"/>
    <dbReference type="OrthoDB" id="306789at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050248">
        <property type="entry name" value="Polysacc_deacetylase_ArnD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0858">Xylan degradation</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="43"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="284" mass="32115" checksum="2BBA2BAEBF7286C2" modified="2014-10-29" version="1">MRKEENMKGIAFAVAGCAMLLLATVGAAPSFNAQQQTLGEKCRCVAFRLDDIQDYYLQGTQIRLMDEFERRNLPLTVGVIGNYFGQDEKIVSFVKEGVAAGRLEVANHGWNHERFTLYSQTEQSDLMAKTNEKLNNILGFRPLIFIAPYNAVNDKTFAAAKDNAILYVSANMTFDKPPYNNKRDDGLWHYPETAETGDLSSDGARWLGYDHEKTMSEIKRGIDENGFAVVTMHPMEFALRDGLSFHDKLDEKQMQELDMLLKSINEQGYEITTLGDLAWRSESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRQ5</accession>
    <name>A0A075MRQ5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Site-specific recombinase XerD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_01782</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRQ5"/>
    <dbReference type="STRING" id="1459636.NTE_01782"/>
    <dbReference type="KEGG" id="nev:NTE_01782"/>
    <dbReference type="HOGENOM" id="CLU_784367_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00397">
        <property type="entry name" value="DNA_BRE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050090">
        <property type="entry name" value="Tyrosine_recombinase_XerCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30349">
        <property type="entry name" value="PHAGE INTEGRASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="2">
        <location>
            <begin position="116"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF83843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="353" mass="40749" checksum="D655E0B5B69E1E0A" modified="2014-10-29" version="1">MRYFVSFLYLLSPPFYYSMILSLTEYIADVQKDGASAHTIEAYKRALERTGVNQVDTERLPELYKVLLTKLEAGVSYVYIKHVMAMLFAYFKIHTDESPFKGKSYHDLYKAIQRLEKPREEYADDEIKKLFRAAAKINDGRNTWRAAALCYYSGLRISGCKGIRWDSVKPVDGTNCVTFRVWSKNKEYSGILSNEVFEAIKRFTDPSNKNNQTPYIVNDHSSKSSPFDKLYRTRLTRALSTECPEIISKVEELEDGKKILHRKSPFHSLRKSFAHKLESAGIDVQDLRYLMNHTPVGVTFSHYIFTEKGKQPIDLVKRMALAYQKCEPLMTPDLLFGEAPKRAVDQWNKEGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRQ9</accession>
    <name>A0A075MRQ9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_01787</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700546.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRQ9"/>
    <dbReference type="STRING" id="1459636.NTE_01787"/>
    <dbReference type="GeneID" id="41597553"/>
    <dbReference type="KEGG" id="nev:NTE_01787"/>
    <dbReference type="HOGENOM" id="CLU_013985_34_9_2"/>
    <dbReference type="OrthoDB" id="87545at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051016">
        <property type="entry name" value="Diverse_Substrate_AcTransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10545">
        <property type="entry name" value="DIAMINE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10545:SF29">
        <property type="entry name" value="GH14572P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="19"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF83848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="167" mass="19221" checksum="79E91E7ED3C506A0" modified="2014-10-29" version="1">MLRNGFEQENDDDVCILQYGIRMACTGDLDALYALMEKYYDYDCHDFDRKKAKKAMRKLLGNRKLGTVLLVLDGSSKPIGYLVLAFGYSLEFGGRDAFIDEFFILQEYRGRKIGQAVLEHAHKVAKKAEVNALHLEVTRHNSAVIGFYRRNGFVDHDRYLMTKRTSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRY6</accession>
    <name>A0A075MRY6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved protein implicated in secretion</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02217</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700877.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRY6"/>
    <dbReference type="STRING" id="1459636.NTE_02217"/>
    <dbReference type="GeneID" id="41597938"/>
    <dbReference type="KEGG" id="nev:NTE_02217"/>
    <dbReference type="eggNOG" id="arCOG00452">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095961_0_0_2"/>
    <dbReference type="OrthoDB" id="6919at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="216" mass="23467" checksum="246613EB5B3C701F" modified="2014-10-29" version="1">MTSFSNNWVKDNKSTMSEKIKEGLGPQQPLKPRIEFAKNKIQAQNQKLDTILEKLKGKEKSLFNQVVSALQRHDTQAGKMVSNEIAQVRKTIKMISQLKMALEQIQMRLETTIDLGDVMVAIGPAMGALTRVRSGLAGVMPEVDRELGEINGVFSDIMMNAGSMGNTSFAFDASGEEVDRILAEAGAVAEQRMTESFPDVPVGSGASRSYAGGNSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRZ3</accession>
    <name>A0A075MRZ3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01879</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385283.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRZ3"/>
    <dbReference type="GeneID" id="43502623"/>
    <dbReference type="KEGG" id="nev:NTE_01879"/>
    <dbReference type="HOGENOM" id="CLU_213585_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="6"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="48" mass="5790" checksum="7484825DF81B4ACB" modified="2014-10-29" version="1">MEISSHRDSQKSRHELLEEIERLKEKLRAKEKEIAVLKKRIAIYKSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MS15</accession>
    <name>A0A075MS15_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00112</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158384871.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MS15"/>
    <dbReference type="STRING" id="1459636.NTE_00112"/>
    <dbReference type="GeneID" id="43502537"/>
    <dbReference type="KEGG" id="nev:NTE_00112"/>
    <dbReference type="HOGENOM" id="CLU_3194635_0_0_2"/>
    <dbReference type="OrthoDB" id="373329at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="46" mass="5163" checksum="C86624B624BE233A" modified="2014-10-29" version="1">MGFLDRLRKKKDDQPHEAAQGSSGATAGEQPRRVKRYTSDGKPVYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MS34</accession>
    <name>A0A075MS34_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_193354065.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MS34"/>
    <dbReference type="STRING" id="1459636.NTE_01860"/>
    <dbReference type="GeneID" id="59387790"/>
    <dbReference type="KEGG" id="nev:NTE_01860"/>
    <dbReference type="HOGENOM" id="CLU_1754604_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="158" mass="17700" checksum="70AB831D54152188" modified="2014-10-29" version="1">MSIDPFIGGDNSRFLIFGLIMSIIVVVIIIVVVIPDLPRLLQTSPPADVPIGLKPNSEGLVKEKLNTLPEMKAFQKKYGEPKVTVEGRQVIYEKTEAGNTSLRYNGTLQREPQVVLIIDIDYDANVERMEFVCVNDHGGGIQLTDQNILHYLEKENCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MS57</accession>
    <name>A0A075MS57_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative low-complexity protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01579</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MS57"/>
    <dbReference type="STRING" id="1459636.NTE_01579"/>
    <dbReference type="KEGG" id="nev:NTE_01579"/>
    <dbReference type="eggNOG" id="arCOG03124">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033401_4_3_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.80">
        <property type="entry name" value="E3 ubiquitin-protein ligase SopA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051082">
        <property type="entry name" value="Pentapeptide-BTB/POZ_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14136">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN KCTD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14136:SF17">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN KCTD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00805">
        <property type="entry name" value="Pentapeptide"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141571">
        <property type="entry name" value="Pentapeptide repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="170" mass="18631" checksum="46C6079B986C000A" modified="2014-10-29" version="1">MWQKSCIKHIMSTEARSLLLEGKVQEFNAWRMKNLTAKLDLTGEDFSGKNIAGAYLNGVVAKNANFSRANLTGTNFVQAELSGANLEGANCKETLFMYAEMKDAKLAGADATKANFMWANLSGADMSAVRMSQTVFVEANMQNVNVAGSDRMGAYLKYAKLDGTPWNEKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MS83</accession>
    <name>A0A075MS83_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA primase small subunit PriS</fullName>
            <ecNumber evidence="11">2.7.7.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">priS</name>
        <name evidence="14" type="ORF">NTE_01965</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.</text>
    </comment>
    <comment type="function">
        <text evidence="13">RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="11">Heterodimer of a small subunit (PriS) and a large subunit (PriL).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11 12">Belongs to the eukaryotic-type primase small subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.-" evidence="11"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385309.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MS83"/>
    <dbReference type="STRING" id="1459636.NTE_01965"/>
    <dbReference type="GeneID" id="41597713"/>
    <dbReference type="KEGG" id="nev:NTE_01965"/>
    <dbReference type="eggNOG" id="arCOG04110">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056123_1_0_2"/>
    <dbReference type="OrthoDB" id="31125at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04860">
        <property type="entry name" value="AE_Prim_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.920.10">
        <property type="entry name" value="DNA primase, PRIM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00700">
        <property type="entry name" value="DNA_primase_sml_arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002755">
        <property type="entry name" value="DNA_primase_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014052">
        <property type="entry name" value="DNA_primase_ssu_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023639">
        <property type="entry name" value="DNA_primase_ssu_PriS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10536">
        <property type="entry name" value="DNA PRIMASE SMALL SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01896">
        <property type="entry name" value="DNA_primase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56747">
        <property type="entry name" value="Prim-pol domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 11 12" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3 11 12" id="KW-0639">Primosome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 11 12" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="11">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AIF84023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="394" mass="43312" checksum="A610E69449E2D91A" modified="2014-10-29" version="1">MSKGATAAADAVRAAFREYYFRRSKMIEPPSDVEKREFGYMQFGGHGMVRHLSFKSMGELVATLITQVPSDVYCSNALYRFPTLAMQEKQWLGADLIFDIDGKDLQLPCVPSHSYPVCANCGQVSSPLLPDDKEEYACSACGNKKAEHIVIPCAKCIDGSKKEAGRLYEFLTGDLGIDRQNINTYFSGNNGFHFHVQDDAYRPLDSQARSDLVGYLAGVGLLAESVGVRRAPGGGDLAFVKFPRSGLGYGWRKKVADKLKIDTTSTLRLTNIVKEKGGYAGFKAELDTMTRQLGVRIDPQVTTDVHRVFRMPGTLNSKSGLAKVKVSDLESFDPFADACLLGDSKVKIRLKAHAKVRLKGENYNISKETAELPAYAAVYFICKGLAEAQLDNTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSG4</accession>
    <name>A0A075MSG4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UDP-N-acetylglucosamine 2-epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700741.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSG4"/>
    <dbReference type="STRING" id="1459636.NTE_02046"/>
    <dbReference type="GeneID" id="41597785"/>
    <dbReference type="KEGG" id="nev:NTE_02046"/>
    <dbReference type="eggNOG" id="arCOG01392">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041674_0_1_2"/>
    <dbReference type="OrthoDB" id="7018at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003331">
        <property type="entry name" value="UDP_GlcNAc_Epimerase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029767">
        <property type="entry name" value="WecB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43174">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE 2-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43174:SF1">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE 2-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02350">
        <property type="entry name" value="Epimerase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDP-N-acetylglucosamine 2-epimerase" evidence="1">
        <location>
            <begin position="205"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="489" mass="56136" checksum="705C60FF20AF351A" modified="2014-10-29" version="1">MNNKTKEDTELDVSRDMLPIKISGSLSSVFEHAKKQRSPILAVVTGTKPDFYKQAPLMVEAAKENVPSFVINTGQHFDDVLGFGMHEFSLNDFVGCNLQIRGDLMEKASELILKFGYFGRYCRKNFRHNESMLPIVHGDTLVAGIAPLAWVFGMGQKVGQNEAGLRSMGPEMMKHLSPAKEPTKKTVRDLVHSQFDGRRWFLAREEPFPEQIDTWICSAGTQFFFAPTQLNKDHLVREGYPEEFVHVVGNSVVDAIHQKRRERPSQSIFDAYPQLEKGEWIRMDIHRRENLTERRFTSIIGGLVDIIERTDNKIVLVMLNATVSALKQYGLEKKLQDLAEDHKDRFLMTPLWKEYAHVIEFLDSGRCWAEMTDSGSMQEELLYFPKVTSLTVRLNTDRPETVFDAKSNILVPPLNRAWLSLMAKEAHEKGEGLGMRLGKKKQIYGRPGQVSKKIIRIIKKEFENGDANFYPWLHQRLGLWKEKQSISYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSG7</accession>
    <name>A0A075MSG7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ester cyclase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02008</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700714.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSG7"/>
    <dbReference type="STRING" id="1459636.NTE_02008"/>
    <dbReference type="GeneID" id="41597755"/>
    <dbReference type="KEGG" id="nev:NTE_02008"/>
    <dbReference type="eggNOG" id="arCOG06513">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100997_5_0_2"/>
    <dbReference type="OrthoDB" id="8685at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030638">
        <property type="term" value="P:polyketide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009959">
        <property type="entry name" value="Cyclase_SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38436:SF1">
        <property type="entry name" value="ESTER CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38436">
        <property type="entry name" value="POLYKETIDE CYCLASE SNOAL-LIKE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07366">
        <property type="entry name" value="SnoaL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="132" mass="15123" checksum="0470A64F082BCD54" modified="2014-10-29" version="1">MSEATAHDNQPSNLEKNKQLVRNFIEDTLNRHDVATADKYLGQIPIRNNNQQAMGTEGFKEHRKRFFQEFPDSHTTIDHIVAEDDRVLVMLTTTATNKQTGKRVTIKSADLYRIENGKIAEHWDVVDRSGMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSH2</accession>
    <name>A0A075MSH2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Gram-positive cocci surface proteins LPxTG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_02051</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987266.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSH2"/>
    <dbReference type="STRING" id="1459636.NTE_02051"/>
    <dbReference type="GeneID" id="41597791"/>
    <dbReference type="KEGG" id="nev:NTE_02051"/>
    <dbReference type="HOGENOM" id="CLU_3021097_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019931">
        <property type="entry name" value="LPXTG_anchor"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01167">
        <property type="entry name" value="LPXTG_anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00746">
        <property type="entry name" value="Gram_pos_anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0964">Secreted</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="Gram-positive cocci surface proteins LPxTG" evidence="3">
        <location>
            <begin position="24"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF84108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="59" mass="6165" checksum="CB4E29543E40A9FD" modified="2014-10-29" version="1">MFGEGGLAAAAALAVLPAGSVKDETTFFILIGLLAALIGVALYMRHKRNSEPDYDPATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSN3</accession>
    <name>A0A075MSN3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative nucleic acid-binding protein, contains PIN domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00277</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699358.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSN3"/>
    <dbReference type="STRING" id="1459636.NTE_00277"/>
    <dbReference type="GeneID" id="41596185"/>
    <dbReference type="KEGG" id="nev:NTE_00277"/>
    <dbReference type="HOGENOM" id="CLU_1773070_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39677">
        <property type="entry name" value="RIBONUCLEASE VAPC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39677:SF4">
        <property type="entry name" value="RIBONUCLEASE VAPC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIN" evidence="1">
        <location>
            <begin position="5"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="146" mass="16231" checksum="148194A0D7598D4F" modified="2014-10-29" version="1">MTTTAKILIDTGVFVNVLNKEKGFDSSVELLEKIRSKKIEGFISVLTIAEIISIYSRLGEEETIVAKTSIESLIGEDRMVPITKQIAELAGRVKADYRMSLGDAFMVAAAISINCEYVVSLDPEIRQVDNKLIKVRTPKQLQDTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MT39</accession>
    <name>A0A075MT39_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9 10">DNA repair and recombination protein RadA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">radA</name>
        <name evidence="15" type="ORF">NTE_01908</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9 11">Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9 11">Belongs to the eukaryotic RecA-like protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700635.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MT39"/>
    <dbReference type="STRING" id="1459636.NTE_01908"/>
    <dbReference type="GeneID" id="41597658"/>
    <dbReference type="KEGG" id="nev:NTE_01908"/>
    <dbReference type="eggNOG" id="arCOG00415">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041732_0_0_2"/>
    <dbReference type="OrthoDB" id="31129at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002052">
        <property type="entry name" value="DNA repair protein RAD51 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00348">
        <property type="entry name" value="RadA_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011938">
        <property type="entry name" value="DNA_recomb/repair_RadA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016467">
        <property type="entry name" value="DNA_recomb/repair_RecA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010995">
        <property type="entry name" value="DNA_repair_Rad51/TF_NusA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003301">
        <property type="entry name" value="PRK04301.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02236">
        <property type="entry name" value="recomb_radA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942:SF30">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN DMC1_LIM15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942">
        <property type="entry name" value="RECA/RAD51/RADA DNA STRAND-PAIRING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14520">
        <property type="entry name" value="HHH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005856">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47794">
        <property type="entry name" value="Rad51 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9 11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 9 11" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 9 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="13">
        <location>
            <begin position="90"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="RecA family profile 2" evidence="14">
        <location>
            <begin position="266"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="320"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="119"/>
            <end position="126"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="NCBIfam" id="TIGR02236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR005856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AIF83967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="338" mass="36904" checksum="9E7F349F2A331A05" modified="2014-10-29" version="1">MTETSKNVMEFEIEDIEGIGPTTARKLREAGISSVMELATAVADELATDLGGSKETASNFIMAAQKLLRESGVLDNEFTTADVELEKRKSLLRCSTGARALDELLLGGIETQAITEFYGEFGSGKSQICHTLCVTAQQPPSEGGLGGGVILIDTEGTFRPERVDQIARARGLDASEVLKRIAICKAYNSSHLELIVKSMGKYIDDFKAKMIIIDSIISLHRAEFSGRGTLADRQQRLNGLMHKLVRIAEIYNVAVIVTNQVQSTPDTFFGDPTKPAGGNVIGHASTYRIYLRKAGNDRVAKIIDSPYHPYSDVRFTVNEKGIDDTEEAPKKKSKDADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MT62</accession>
    <name>A0A075MT62_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Streptogramin lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02694</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MT62"/>
    <dbReference type="STRING" id="1459636.NTE_02694"/>
    <dbReference type="KEGG" id="nev:NTE_02694"/>
    <dbReference type="eggNOG" id="arCOG03564">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_562156_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051344">
        <property type="entry name" value="Vgb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40274">
        <property type="entry name" value="VIRGINIAMYCIN B LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40274:SF3">
        <property type="entry name" value="VIRGINIAMYCIN B LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24684">
        <property type="entry name" value="Vgb_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="485" mass="52097" checksum="10444E7980B63238" modified="2014-10-29" version="1">MWRYVVAPALAVAVLLLAVLPFQVVNAQTVTTGNDDVTYTKESKFIKEFQINDLKEDRGLGGITTDARGMPWFYFSTNATSAVFSFDPSGNKFTRYDVQGETVVDNPVIKLAAGQLVFDREGALWFTDARTNSIGRLANGQIQLIPIPTEKSGPMGIALSPDGGSVWFAEILGNKIGKVDTASAKITAEYSLPEQSGPTFLDFDDSGALWVSLSYSRSVMRIEPWLLASSSAAGMPILSLPKPDSFSPFGIAVANNGKLYLSDHGSSRVIVSDATLQNYTSYWTSPSGSFPATLPSQIVSDDKSGNVYFPEHGGNRIARIDSQGVMTEYEIPTGPLSAAVFAAVSHDGKKVWFTEWASNKVAYLDASAQVPFDAQILQPQQSITLTKSGAASLDVLIKKSAIANGSDNSLGSLSLSQVEVGLTGMTESGLAGVTYHANPPRVNLQENASSSSAESNIQLQARITPSPAIIPRWSRFRLLRRTMTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MT63</accession>
    <name>A0A075MT63_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00427</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699467.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MT63"/>
    <dbReference type="STRING" id="1459636.NTE_00427"/>
    <dbReference type="GeneID" id="41596306"/>
    <dbReference type="KEGG" id="nev:NTE_00427"/>
    <dbReference type="eggNOG" id="arCOG06357">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117488_0_0_2"/>
    <dbReference type="OrthoDB" id="11273at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="191" mass="20039" checksum="D0F985A98ACC47E8" modified="2014-10-29" version="1">MQLVRINSATLIDSVKAGIAAGQAAAWAIFGLILAVDATLVTPPGTFYKMIGMALGQGPSADVYLGFLMHMITATVIGIIYMIISNSVKKLYIRSVPKGLATGVITGIVVWAILFLPLNFGLVQPMLQGIVAQGPQAPMFQLAEKLLTLSTTILAGSLALHIVFGGVLGFIGRIATSSGEILGEQEQEQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTC0</accession>
    <name>A0A075MTC0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TIGR00299 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701330.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTC0"/>
    <dbReference type="STRING" id="1459636.NTE_02780"/>
    <dbReference type="GeneID" id="41598469"/>
    <dbReference type="KEGG" id="nev:NTE_02780"/>
    <dbReference type="eggNOG" id="arCOG02701">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028523_2_1_2"/>
    <dbReference type="OrthoDB" id="10691at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.300">
        <property type="entry name" value="mk0293 like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1380">
        <property type="entry name" value="Transcriptional regulatory protein pf0864 domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002822">
        <property type="entry name" value="Ni_insertion"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00299">
        <property type="entry name" value="nickel pincer cofactor biosynthesis protein LarC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36566">
        <property type="entry name" value="NICKEL INSERTION PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36566:SF1">
        <property type="entry name" value="PYRIDINIUM-3,5-BISTHIOCARBOXYLIC ACID MONONUCLEOTIDE NICKEL INSERTION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01969">
        <property type="entry name" value="Ni_insertion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0533">Nickel</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="412" mass="43623" checksum="8605C1BB95567411" modified="2014-10-29" version="1">MTNDKIAVIDCQVAGIAGDMLVSALVDAGASAKKVRDAIFACQDSLKGSKISNASFEKIVTHGFSATQLQLSYKDGVHERKGAEMLRALTKTCDTLDLEQRAKAFALDTLKTIVSAEARVHGEDFSNVHLHEASSVDTLADIVGCATALQDLSLFGSKIVSTQVAVGGGKLTFSHGTVPNPADAILHIFQGRHFALAGGQAKEELTTPTGAALLANLAEGSVDYYPTIVPEKIGYGAGGKKFEGFANVVRVLIGSSPVALEKDTVCVVETNVDDATGEVMGNLIDRLTDAGAKDVTIIPGTTKKNRPTYLVRVVADNFLLNAVLSILFSESGTLGARVQQVERYVLQRAVVTVPVTIGENTFNVHVKVAKDAQGNTMGAKPEFEDIKIIAARLGVPARRVMEIVNAQVVHKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTC9</accession>
    <name>A0A075MTC9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein pelota homolog</fullName>
            <ecNumber evidence="9">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pelA</name>
        <name evidence="11" type="ORF">NTE_02315</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="9">The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the eukaryotic release factor 1 family. Pelota subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="9"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700951.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTC9"/>
    <dbReference type="STRING" id="1459636.NTE_02315"/>
    <dbReference type="GeneID" id="41598031"/>
    <dbReference type="KEGG" id="nev:NTE_02315"/>
    <dbReference type="eggNOG" id="arCOG01741">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023334_0_0_2"/>
    <dbReference type="OrthoDB" id="31300at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070651">
        <property type="term" value="P:nonfunctional rRNA decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070966">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, no-go decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070481">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, non-stop decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032790">
        <property type="term" value="P:ribosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071025">
        <property type="term" value="P:RNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="entry name" value="eRF1 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.870">
        <property type="entry name" value="Pelota, domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01853">
        <property type="entry name" value="PelO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005140">
        <property type="entry name" value="eRF1_Pelota-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038069">
        <property type="entry name" value="Pelota/DOM34_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023521">
        <property type="entry name" value="Pelota_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058547">
        <property type="entry name" value="Pelota_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004405">
        <property type="entry name" value="TF_pelota"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00111">
        <property type="entry name" value="pelota"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10853">
        <property type="entry name" value="PELOTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10853:SF0">
        <property type="entry name" value="PROTEIN PELOTA HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26356">
        <property type="entry name" value="Pelota_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01194">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159065">
        <property type="entry name" value="Dom34/Pelota N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1/Pelota-like N-terminal" evidence="10">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIF84368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="352" mass="38401" checksum="20671240DDC700CB" modified="2014-10-29" version="1">MIVKQSDHSANALLVIPEDADDLFTLRRVIAPGDYAIADTTRVVKQESDYGRPDRGERIKVRLTIRVDRIELDASVDRLRISGTITHTSNELVSKGVHHALSVQAGDILTIDKGRKWQDVELKLLKRSGDGSSFILVAIDTQEAAVAKVTGTHVKIIPNIYSGQQGKRYPTKNPSLDSFFADTAKTVGSVLSEGDRIIVFGPGETRRRFYNALDRNGLPKERAQVVDGVDVAGEDGVFVFLRSPAMKDAMSASKLATVSAMLDQVMLMVNRGENKYAVGLKDITEAANIKAIEAIIFSDSVFKTAEEDAVVKLLNSVESYGARTYAVDSSTDIGLRVSLLGGMVALLRYAMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTF4</accession>
    <name>A0A075MTF4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02843</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTF4"/>
    <dbReference type="STRING" id="1459636.NTE_02843"/>
    <dbReference type="KEGG" id="nev:NTE_02843"/>
    <dbReference type="eggNOG" id="arCOG08825">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1472029_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="177" mass="19555" checksum="4906EBFB5959E46A" modified="2014-10-29" version="1">MLLLLPLRFLAIIVTLFSAGVFFFAPAYAHFFGATKQVDNYQIVFQPYPSSPIIGTNSTLNFSVLANDGNNLYNVYTSVVIADKRTGNPIYQEPYRLSEISDVTTRYRFDTPGDYVVTLQTRIPGDAKYASQPLAASFDVTAFPPGIPLDELLLYYVTPAAVVIAGIAVYLHSKNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTI9</accession>
    <name>A0A075MTI9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Acetate--CoA ligase</fullName>
            <ecNumber evidence="2 6">6.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NTE_02371</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.1" evidence="2 6"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTI9"/>
    <dbReference type="STRING" id="1459636.NTE_02371"/>
    <dbReference type="KEGG" id="nev:NTE_02371"/>
    <dbReference type="eggNOG" id="arCOG01529">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_3_6_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043955">
        <property type="term" value="F:3-hydroxypropionyl-CoA synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003987">
        <property type="term" value="F:acetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019427">
        <property type="term" value="P:acetyl-CoA biosynthetic process from acetate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043427">
        <property type="term" value="P:carbon fixation by 3-hydroxypropionate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05966">
        <property type="entry name" value="ACS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000001">
        <property type="entry name" value="Acetyl-coenzyme A synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011904">
        <property type="entry name" value="Ac_CoA_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02188">
        <property type="entry name" value="Ac_CoA_lig_AcsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001208">
        <property type="entry name" value="PRK00174.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095:SF14">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyl-coenzyme A synthetase N-terminal" evidence="9">
        <location>
            <begin position="27"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="7">
        <location>
            <begin position="86"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="8">
        <location>
            <begin position="528"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="NCBIfam" id="TIGR02188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIF84423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="649" mass="72009" checksum="744954FF3FB6842E" modified="2014-10-29" version="1">MSSGKPSKLYEESSGVKVTVRPGTALEDMSKEALSDPEKFWAKQARGLDWHRPWDRVLDWNPPFARWFSGGLLNASVNCLDRHIATDVKNKAAIIWESESGESRTLTYFQLYRLVNRFANVLKSLGVQKGDRVTIYMPLVPELPVAMLACARIGATHSVVFSGFSSQALIDRVNDAQSKVIVTADGGFRKGKLVDLKKVVDESLVQTPSVQHVVVLRRAGNEVRMGPKDVWWHEAIDKVPAFCEPEMVESTHPLYILYTSGTTGKPKGVMHGTAGYLVHLYATAKWVFDFKKDDIFFCTADIGWVTGHSYMVYAPLMHGVTEIMYDGAPDHPRPDRYWAVAEKHGATILYTTPTALRMYMKYGDAVPNSFDLSSLRLLGTVGEPINPEVWQWYFTTIGKRRRPIIDTWWQTETGGIMLSACTGIDFVPMKPGSATFPVPGVDAAVVDDNGNPVPPGTKGYIVVRKPWPGMLLSLWGDDEKYKKTYWSKFEGVYYPGDYALVDKDGYLWLLGRADDVLKVAGHRLGTMELESAFVSHRAIAEAAVASKPDTTKGESIIAFLVVKEGTTAAPDALRKEIVEHIRKTVGPIATPDEVYFVGKLPKTRSGKIMRRLLKAIACGDKIGDITTLEDGAAIDEVRHAYDELKKAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTJ3</accession>
    <name>A0A075MTJ3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02466</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226986970.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTJ3"/>
    <dbReference type="STRING" id="1459636.NTE_02466"/>
    <dbReference type="GeneID" id="41598172"/>
    <dbReference type="KEGG" id="nev:NTE_02466"/>
    <dbReference type="eggNOG" id="arCOG11612">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2857223_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="63" mass="7030" checksum="426AA40223420551" modified="2014-10-29" version="1">METIHCGCRCIVCKGQKLEGRSFTATDGYLDIHHTCKDCGAHFDHLDGTVFEKCETCSYAKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTM5</accession>
    <name>A0A075MTM5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02433</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701050.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTM5"/>
    <dbReference type="STRING" id="1459636.NTE_02433"/>
    <dbReference type="GeneID" id="41598141"/>
    <dbReference type="KEGG" id="nev:NTE_02433"/>
    <dbReference type="HOGENOM" id="CLU_2893374_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="64" mass="6731" checksum="FA57D3041649FBDC" modified="2014-10-29" version="1">MISSIVIFVLAFAALGLLLGYASVFDVQPQQHERAVRADIGSNNNNGTSITLGEQVNVQVQSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTR4</accession>
    <name>A0A075MTR4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">UvrABC system protein A</fullName>
            <shortName evidence="14">UvrA protein</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Excinuclease ABC subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">uvrA</name>
        <name evidence="16" type="ORF">NTE_02484</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Forms a heterotetramer with UvrB during the search for lesions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the ABC transporter superfamily. UvrA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701090.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTR4"/>
    <dbReference type="STRING" id="1459636.NTE_02484"/>
    <dbReference type="GeneID" id="41598188"/>
    <dbReference type="KEGG" id="nev:NTE_02484"/>
    <dbReference type="eggNOG" id="arCOG04694">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001370_0_2_2"/>
    <dbReference type="OrthoDB" id="7896at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03270">
        <property type="entry name" value="ABC_UvrA_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03271">
        <property type="entry name" value="ABC_UvrA_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1580.10:FF:000002">
        <property type="entry name" value="UvrABC system protein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.280">
        <property type="entry name" value="ABC transporter ATPase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1580.10">
        <property type="entry name" value="ABC transporter ATPase like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00205">
        <property type="entry name" value="UvrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004602">
        <property type="entry name" value="UvrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041552">
        <property type="entry name" value="UvrA_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041102">
        <property type="entry name" value="UvrA_inter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001503">
        <property type="entry name" value="PRK00349.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00630">
        <property type="entry name" value="uvra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43152">
        <property type="entry name" value="UVRABC SYSTEM PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43152:SF3">
        <property type="entry name" value="UVRABC SYSTEM PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17755">
        <property type="entry name" value="UvrA_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17760">
        <property type="entry name" value="UvrA_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 14" id="KW-0228">DNA excision</keyword>
    <keyword evidence="13 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="12 14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11 14" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="3 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0677">Repeat</keyword>
    <keyword evidence="14" id="KW-0742">SOS response</keyword>
    <keyword evidence="9 14" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="598"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="14">
        <location>
            <begin position="258"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="14">
        <location>
            <begin position="743"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="33"/>
            <end position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="644"/>
            <end position="651"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AIF84533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="953" mass="105756" checksum="3566803A0D63F9DD" modified="2014-10-29" version="1">MAHDKIIIKGARQHNLKNINVEIPKNKLVVITGLSGSGKSTLAFDTIYAEGQRRYVESLSAYARQFLELMDKPDVDSIDGLSPAISIQQKTTSKNPRSTVGTVTEIYDYLRLLFARIGIPHCPRCGRRIASQSVDSITESVLKTAEGKSVMVLGPVVQAKKGTYEKLFDELKQEGYSRIRLDGEVTNLEDEEDEKPKVPRLDKQKKHTIEVIVDRLKPSAEEKSRLFESIQSALKVGAGTAVVSVDGKDTMYSQKNACPHCEISIGDIEPRTFSFNSPFGACQGCNGLGIKIEFDPDLIIPDKQKSILDGAIKPWMGHFATFRASMLKDVGRKYGFDLAMPVSKMTQRQLNVILYGTDENIHFKYESKYSDSRWEYNGTFEGVIPNLERTYRQTESESKREDLMQFMRERPCERCGGRRLREEALAVRIGDKSIMQVCDLSIDACYNFFQEIELSETERYIARTILKEIMSRLEFLRNVGLNYLTLNRMSATLSGGESQRIRLATQIGSNLTGVLYVLDEPTIGLHQRDNSRLIDTLKKLRDLDNTLVVVEHDEEVIRSSDWIIDIGPGAGIHGGQIVSSGTLEDIIASGDSITGAFLRGEQTAAHMHERKKPGRWIAVHGAQENNLKNIDVRFPLGCMSVVTGVSGSGKSTLVNDILFKALAGHFFGAKDRPGKHDRISGLENADKVIGIDQSPIGRTPRSNAATYVNAFTPIRELFAKTPHAREMGYTAGRFSFNVSEGRCEACEGGGVKKIEMQFLPDVYVTCDECKGRRYNSETLLVKYKGKTISDVLDMTIEEALSFFSNIPAITKKLQTLNDVGLGYLRLGQPATTMSGGEAQRIKLAAELSRRDTGKTVYILDEPTTGLHFADVSKLLHVLKRLVELGNTAIIIEHNLDVIASADWIVDLGPEGGEGGGTVVAEGTPEQISENTASYTGQYLKQKLAMDQKLVRHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTS3</accession>
    <name>A0A075MTS3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226986974.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTS3"/>
    <dbReference type="GeneID" id="41598198"/>
    <dbReference type="KEGG" id="nev:NTE_02494"/>
    <dbReference type="HOGENOM" id="CLU_1954558_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="128" mass="14308" checksum="81DB9A7C0428609B" modified="2014-10-29" version="1">MQSLRIGWMLLLATGIGILGFGLITSAYPQISSDYSGIKEEELLLRTIGVATTGMGIFGVMITLTAYRRGEKWAWLALWYYPVFWLLHLALGLPPGNDHVHQVVFIVLSLLGLLLPVRRFLYSKSVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTW6</accession>
    <name>A0A075MTW6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02541</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701132.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTW6"/>
    <dbReference type="STRING" id="1459636.NTE_02541"/>
    <dbReference type="GeneID" id="41598238"/>
    <dbReference type="KEGG" id="nev:NTE_02541"/>
    <dbReference type="HOGENOM" id="CLU_1792032_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="144" mass="16152" checksum="336DA3F3264BCCCF" modified="2014-10-29" version="1">MTVYIIDADNIDFEGINKFKKMGLITNGEPILRSIVLEQTIQNKDWPVFRIDTPYGKFKEIFEKFLPELMTVVSGNADSKTLSDNAGVDTEVDTETKKKEVDKVKVENADPEIPQYLQTMQQVVNTVGVPILEKFGGGLAQKVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTY3</accession>
    <name>A0A075MTY3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03087</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701573.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTY3"/>
    <dbReference type="STRING" id="1459636.NTE_03087"/>
    <dbReference type="GeneID" id="41598749"/>
    <dbReference type="KEGG" id="nev:NTE_03087"/>
    <dbReference type="eggNOG" id="arCOG08805">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100103_1_0_2"/>
    <dbReference type="OrthoDB" id="8363at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="176" mass="20768" checksum="8784FA78E18607EC" modified="2014-10-29" version="1">MTNPTEAATFRFDKTMLDQLRVEAEQKQINLNTLLNQIVRSHIEWHANAARAGFIPIRRGVIKRLFDLLTKEQIDALAADVSRGLTDETMMIMTSERTEETIYELLERWIRISGFNYRHEISEDARIFVIQHNMGENWSHYISRLIEYAASEFTDMKPETQVTENALFIRIRRVRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUA6</accession>
    <name>A0A075MUA6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00317</name>
        <name evidence="2" type="ORF">NTE_02243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUA6"/>
    <dbReference type="KEGG" id="nev:NTE_00317"/>
    <dbReference type="KEGG" id="nev:NTE_02243"/>
    <dbReference type="HOGENOM" id="CLU_3039193_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="61" mass="6833" checksum="5479E4552E6DDA92" modified="2014-10-29" version="1">MQSSFSALAMPIVNSLGASGYPALQTFLSHILDKNRLFYSGKRLFFILLAAVTFEMLEEVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUB4</accession>
    <name>A0A075MUB4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NTE_00853</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699799.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUB4"/>
    <dbReference type="STRING" id="1459636.NTE_00853"/>
    <dbReference type="GeneID" id="41596696"/>
    <dbReference type="KEGG" id="nev:NTE_00853"/>
    <dbReference type="eggNOG" id="arCOG00009">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG00451">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
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        <property type="entry name" value="APC_superfamily"/>
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        <property type="entry name" value="INNER MEMBRANE TRANSPORT PROTEIN YBAT"/>
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        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
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    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
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            <end position="53"/>
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            <begin position="180"/>
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            <dbReference type="SAM" id="Phobius"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
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    <sequence length="782" mass="84581" checksum="2751EF4E700AFAD4" modified="2014-10-29" version="1">MSAPADGGQRPTAAAEAHGQHQLVRTLGLTDVVMVGIAAMIGGAIFVLTGPAIGLAGSAVIIAFVINGIITLFTAMVYAELGSAMPEAGGGYLWIREGLPRPNAFISGWMAWFAHIVAGSLYAVGFGSFAYSLLNVAGVLPSQMLLGIFPVDKLIAVASIAAFTYVNVKGTSETGKAGTAVTLVQLGAILAILAFGLWGILNNPGWEQRFSEQFLPLGISGMVAAMGLTFIAFEGYEIIVQTGEEVKNPKRNIPKAIFISLAIVVTLYCLMAFVALAATNAPDGTPAWKFIGGDNAELGISRAVDLFMPYGAFVVLAGGIVSTLAALNATTFSSARVALAMGRNYNLPHKLSEIHPVNKTPYVAAIVSGIIMAVMAYALPLNDIALAAGVIFLLLFTQVNVSVITIRRMYGNKLDYGFKTPLFPLIPVIGIVLKLGLAIYLLVTQPLSWVITILWILVGFVLYRMYTFKKEVEHYAPLVTQQGAEERRAYRVLLMYSPENPDRLAKYATRIARETAGEVNVLRIITVPLQTPLSAGTAFAESARRAFQPLEEVFEKRGVPSHYLVRISHDATEAMLATIEEQKVNLLIADLETLRRNKKLLTLATCDILAIAAESDELEMEPVREQVEADLEMHAVPAEEKKNMVVIYDGGPHANLVLKITSWLEHSGRFKVNLVSVSKKEEETDGSVAMKPDYLSQLGVDLTEVHLGASMQESAANVFSAIDAYRPDIVVMGASIGRFSVLDNPQMLQMLKRFHCPVMIARDFGIPGMYHATSFVRRMLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUC1</accession>
    <name>A0A075MUC1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="13 19">Inosine-5'-monophosphate dehydrogenase</fullName>
            <shortName evidence="13">IMP dehydrogenase</shortName>
            <shortName evidence="13">IMPD</shortName>
            <shortName evidence="13">IMPDH</shortName>
            <ecNumber evidence="13 19">1.1.1.205</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">guaB</name>
        <name evidence="21" type="ORF">NTE_03212</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13 19">
            <text>IMP + NAD(+) + H2O = XMP + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="1.1.1.205"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="13">Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.</text>
    </comment>
    <comment type="pathway">
        <text evidence="13 19">Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 13">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13 18">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.205" evidence="13 19"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701676.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUC1"/>
    <dbReference type="STRING" id="1459636.NTE_03212"/>
    <dbReference type="GeneID" id="41598869"/>
    <dbReference type="KEGG" id="nev:NTE_03212"/>
    <dbReference type="eggNOG" id="arCOG00612">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022552_2_1_2"/>
    <dbReference type="OrthoDB" id="21361at2157"/>
    <dbReference type="UniPathway" id="UPA00601">
        <property type="reaction ID" value="UER00295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006177">
        <property type="term" value="P:GMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04601">
        <property type="entry name" value="CBS_pair_IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GMP reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01964">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015875">
        <property type="entry name" value="IMP_DH/GMP_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01302">
        <property type="entry name" value="IMP_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911:SF111">
        <property type="entry name" value="INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="INOSINE-5-MONOPHOSPHATE DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000130">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01240">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00487">
        <property type="entry name" value="IMP_DH_GMP_RED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 17" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6 13 19" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="4 13 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13 15" id="KW-0520">NAD</keyword>
    <keyword evidence="9 13 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 13 16" id="KW-0630">Potassium</keyword>
    <keyword evidence="7 13 19" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CBS" evidence="20">
        <location>
            <begin position="92"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="20">
        <location>
            <begin position="151"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimidate intermediate" evidence="13 14">
        <location>
            <position position="301"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="393"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="396"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="244"/>
            <end position="246"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 15">
        <location>
            <begin position="294"/>
            <end position="296"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="13 16">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="13 16">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="13 16">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
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        <location>
            <begin position="334"/>
            <end position="336"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="357"/>
            <end position="358"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
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        <location>
            <begin position="381"/>
            <end position="385"/>
        </location>
        <ligand>
            <name>IMP</name>
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        </ligand>
    </feature>
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        <location>
            <position position="414"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="468"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="469"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU003927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="AIF85241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="477" mass="51341" checksum="47E2DCA8A8940DC5" modified="2014-10-29" version="1">MDFREGLTFDDVLLVPKRSPIVSRSQTDLRTKLSRNISLNIPLISANMDTVTESHMAIALAREGGIGIIHRFMTIEDQVDEVLKVKRSESVVIEQPYTVKANTTVAELYKHMAEYGVSGLLVEDGGKLAGIITRRDITFEKNMKRKVSELMTRQVITAKAGTTIEQAKEILHKHRIEKLPLVDDKGRIAGLITSKDILKMDEYPHAAKDRKGRLLVGAAVGVKGDYLERTEALLEAGADTIVVDIAHGHSENALNTVHMIKKAFPSCDLIAGNVATGDGARDLIKAGVDAVKVGVGSGSICITRVVTGSGVPQLTAVIDAVKAAKEFDIPVISDGGIRTSGDLTKALAAGASSAMIGSMFGGTDESPGKTLVKNGKKYKMYRGMASYMASLGRKYRQEGPEVVDSDDLNDYVPEGVEAMVPYKGSVVEIVRQLAGGLRSGLSYCGAKSIPEMQRNAEFVRITGAGFIESQPHDVDVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUE5</accession>
    <name>A0A075MUE5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUE5"/>
    <dbReference type="STRING" id="1459636.NTE_03247"/>
    <dbReference type="KEGG" id="nev:NTE_03247"/>
    <dbReference type="eggNOG" id="arCOG02889">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_530841_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M14" evidence="1">
        <location>
            <begin position="1"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="470" mass="53188" checksum="F3560F3E313697F0" modified="2014-10-29" version="1">MDHIMLEQEHGFSHPGSSSEIIGYSEKGRPLVVGYYYNNEGSHLDSGKKNPKVRVFVLAGQHGDERYGRKAVGRLVNILDDNSSIYQREFQSLQIAILQDANPDGASMRSRANASGIDLNRDHQFLNAAETRAMHSFIRKWRPHLVIDVHNYPSKRKHLLKKGLVLHHDVFVDVPTSPCVFANPCMNQKTLDQFLHEIRADLQLHGFSCERYCMIRPSGRVRHSTPDVIDARNFLTLRYNAMTVLLEGRTPTRKDGELKRELLVAAQLQALLSILAWSVRNGSHLRSISNYIPVKGERVPIQSRYAAARQALRMSFKTVKSDNIEILSLPNYTPYLEISRYVDLPAAYAVPKENKKLLNLLHRHGFVSMSLDSPCAERAAVQRYYIQSRGSKRENKPQSRAPAMAAIVTAAGPEKRALCDDSYEIFPSSQLGGHSLAILLEPKSKYGLCRNKRFGLSLLPESYYPILRVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUL5</accession>
    <name>A0A075MUL5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02329</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700963.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUL5"/>
    <dbReference type="STRING" id="1459636.NTE_02329"/>
    <dbReference type="GeneID" id="41598045"/>
    <dbReference type="KEGG" id="nev:NTE_02329"/>
    <dbReference type="eggNOG" id="arCOG08657">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_152985_0_0_2"/>
    <dbReference type="OrthoDB" id="10488at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="109" mass="12089" checksum="6E6F30E2E6AF470F" modified="2014-10-29" version="1">MTITKSDVEPGRIRGPPAKSKVLMSDMAMQNQGFVITKVEMCQYVERTDEKLGDYSLLIAIVHTDRGTVEMKYDEGFRGPDAFDSAVTMLLQYVGLSALINRALIALSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUP4</accession>
    <name>A0A075MUP4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Urease, gamma subunit</fullName>
            <ecNumber evidence="3">3.5.1.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_02892</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.1.5" evidence="3"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701418.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUP4"/>
    <dbReference type="STRING" id="1459636.NTE_02892"/>
    <dbReference type="GeneID" id="41598571"/>
    <dbReference type="KEGG" id="nev:NTE_02892"/>
    <dbReference type="eggNOG" id="arCOG04528">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_145825_1_0_2"/>
    <dbReference type="OrthoDB" id="42431at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009039">
        <property type="term" value="F:urease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00390">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.280.10">
        <property type="entry name" value="Urease, gamma-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00739">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012010">
        <property type="entry name" value="Urease_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002026">
        <property type="entry name" value="Urease_gamma/gamma-beta_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036463">
        <property type="entry name" value="Urease_gamma_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050069">
        <property type="entry name" value="Urease_subunit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009712">
        <property type="entry name" value="PRK13241.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00193">
        <property type="entry name" value="urease_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33569">
        <property type="entry name" value="UREASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33569:SF1">
        <property type="entry name" value="UREASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00547">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001223">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54111">
        <property type="entry name" value="Urease, gamma-subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF84930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="100" mass="11214" checksum="5D6C0D13F7DE7885" modified="2014-10-29" version="1">MMLAPREMEKMWIWTAAQIAEGRKKRGIKLNYPETVAYIANYVVEGAREGKTVAQLMQSARTILKKNDVMAGVPDMIHTVQVEATFPDGTKLVTVHDPVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUQ6</accession>
    <name>A0A075MUQ6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Flagellin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NTE_02355</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Archaeal flagellum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the archaeal flagellin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700987.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUQ6"/>
    <dbReference type="STRING" id="1459636.NTE_02355"/>
    <dbReference type="GeneID" id="41598071"/>
    <dbReference type="KEGG" id="nev:NTE_02355"/>
    <dbReference type="eggNOG" id="arCOG01829">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084671_0_0_2"/>
    <dbReference type="OrthoDB" id="12034at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097589">
        <property type="term" value="C:archaeal-type flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097588">
        <property type="term" value="P:archaeal or bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013373">
        <property type="entry name" value="Flagellin/pilin_N_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002774">
        <property type="entry name" value="Flagellin_arc-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02537">
        <property type="entry name" value="arch_flag_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35903">
        <property type="entry name" value="FLAGELLIN B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35903:SF1">
        <property type="entry name" value="FLAGELLIN B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01917">
        <property type="entry name" value="Flagellin_arch-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0974">Archaeal flagellum</keyword>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="6" id="KW-0282">Flagellum</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF84407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="230" mass="23697" checksum="A25F64E1948CA2FE" modified="2014-10-29" version="1">MEVRRTPNNNRNRHNRRGVVGIESAIVLIAFVIVAAALSFVVLNMGFSTTQKAKSTITSGLGEASSAIEIAGQVTGKGNTTASKVDAYTIPIKLASGGSSVDITASKTAVKYFSKSVTYDNIFKGTLTSGTYTDINSALTAAKTAGYINEIPGVGAGSNSTAAFIYFTANVNNNSIVDAGEQAVLAIAYKNGDRPAALDTVNTEIIVSAGAPLTVVRSVPTITDAVLNLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUU0</accession>
    <name>A0A075MUU0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUU0"/>
    <dbReference type="STRING" id="1459636.NTE_02385"/>
    <dbReference type="KEGG" id="nev:NTE_02385"/>
    <dbReference type="HOGENOM" id="CLU_3227635_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="43" mass="4776" checksum="8FA2F5B8EA731E91" modified="2014-10-29" version="1">MRGLKKMDTVALPGYQLYHNYFREHEGLNGKTPAEIAGIKIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MV99</accession>
    <name>A0A075MV99_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sulfite reductase, beta subunit (Hemoprotein)</fullName>
            <ecNumber evidence="10">1.8.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NTE_03053</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SR1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.8.1.2" evidence="10"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701552.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MV99"/>
    <dbReference type="STRING" id="1459636.NTE_03053"/>
    <dbReference type="GeneID" id="41598721"/>
    <dbReference type="KEGG" id="nev:NTE_03053"/>
    <dbReference type="eggNOG" id="arCOG02055">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015667_1_1_2"/>
    <dbReference type="OrthoDB" id="15347at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004783">
        <property type="term" value="F:sulfite reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.480.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="entry name" value="Sulfite Reductase Hemoprotein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051329">
        <property type="entry name" value="NIR_SIR_4Fe-4S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006066">
        <property type="entry name" value="NO2/SO3_Rdtase_FeS/sirohaem_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32439:SF9">
        <property type="entry name" value="BLR3264 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32439">
        <property type="entry name" value="FERREDOXIN--NITRITE REDUCTASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00397">
        <property type="entry name" value="SIROHAEM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="Nitrite and sulphite reductase 4Fe-4S domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="Nitrite/Sulfite reductase N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitrite/Sulfite reductase ferredoxin-like" evidence="9">
        <location>
            <begin position="71"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Nitrite/sulphite reductase 4Fe-4S" evidence="8">
        <location>
            <begin position="140"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Nitrite/Sulfite reductase ferredoxin-like" evidence="9">
        <location>
            <begin position="355"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="Nitrite/sulphite reductase 4Fe-4S" evidence="8">
        <location>
            <begin position="434"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIF85088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="621" mass="68402" checksum="33D867DAB2ABC595" modified="2014-10-29" version="1">MSKSRVATTTAANSKQKGISPPKPNPRWGREEETEFFAKKVKLFRQGKISEDDFRRFRLQHGAYGSRLHADYSMVRIKVPSGEITAEQVEKIASLSEAFSIGSAHVSTRQNIQLHWVQLEDVSEVMRGLVEAGLTTREACGNTVRNVMCSHFAGVCPDEAFDATPYAMAIARFFLRNPMCQNLPRKFKINFGCCEKHGLVKVADIGLVPTVKEGENGAKVRGFRIYLGGGLGAASFIGHALEDFTPEDRVLATCMATVRLFDRHGNRENMARNRMRYLVHETGWEKFQKMVLKERTAVEMTTSLATASMYDVKSQEDKRQLPKAPSSRMAKLPMFDKVTKDGPAFERWLHSNTVPQKQEGYFTVFVTLGAGDITASQLRVLASAIRDFSAEGAARNTPQQNFAIRYVRGTDLRDFYNRLATAGLANPGALTIASSVGCSGTTSCNLAITNSHRLAKEVQRKFLELGLDTDDDLRDATIKISGCPNSCGQHEIATIGFFGGASRIGNAMSPTYTMLFGGSAGEQGELGRSVMRVPAKRVIDAILKIIEMYRSERVQGETLHQWVVKVVKGQGTGAIKSLEDIKNALVPVIQLPAIEQDPDAYRDYGSDAKFTAKTARGECAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVA3</accession>
    <name>A0A075MVA3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YdhG-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01131</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700014.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVA3"/>
    <dbReference type="STRING" id="1459636.NTE_01131"/>
    <dbReference type="GeneID" id="41596945"/>
    <dbReference type="KEGG" id="nev:NTE_01131"/>
    <dbReference type="eggNOG" id="arCOG09457">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128703_3_0_2"/>
    <dbReference type="OrthoDB" id="350500at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014922">
        <property type="entry name" value="YdhG-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08818">
        <property type="entry name" value="DUF1801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159888">
        <property type="entry name" value="YdhG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YdhG-like" evidence="1">
        <location>
            <begin position="44"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="152" mass="17412" checksum="5A568AEDBAD1DA79" modified="2014-10-29" version="1">MVGKLDSLTFAKKINMRKENFFQPTTSMPTTVDEYLATLPGDVRDALEKLRRTIKSIVPGAEERIAYRIPIFRLERDLVGFSAQRNPQKRLCSFYTMSPPLVKAMKKDLQNYRVSGATIHFIPEKPLPAALVKKIVRARVKELSVKARKYKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVB0</accession>
    <name>A0A075MVB0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Arsenite efflux ATP-binding protein ArsA</fullName>
            <ecNumber evidence="4">3.6.3.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_03163</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arsA ATPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.16" evidence="4"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385617.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVB0"/>
    <dbReference type="STRING" id="1459636.NTE_03163"/>
    <dbReference type="GeneID" id="41598821"/>
    <dbReference type="KEGG" id="nev:NTE_03163"/>
    <dbReference type="eggNOG" id="arCOG01833">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG02849">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040761_1_0_2"/>
    <dbReference type="OrthoDB" id="46198at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02035">
        <property type="entry name" value="ArsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025723">
        <property type="entry name" value="ArsA/GET3_ATPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040612">
        <property type="entry name" value="ArsA_HSP20-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016300">
        <property type="entry name" value="ATPase_ArsA/GET3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00345">
        <property type="entry name" value="GET3_arsA_TRC40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803">
        <property type="entry name" value="ARSENICAL PUMP-DRIVING ATPASE ARSENITE-TRANSLOCATING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803:SF3">
        <property type="entry name" value="ATPASE GET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02374">
        <property type="entry name" value="ArsA_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17886">
        <property type="entry name" value="ArsA_HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ArsA/GET3 Anion-transporting ATPase-like" evidence="2">
        <location>
            <begin position="1"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="ArsA HSP20-like" evidence="3">
        <location>
            <begin position="325"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF85195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="391" mass="42994" checksum="4676780E2B4364C6" modified="2014-10-29" version="1">MRLIIYTGKGGTGKTVTSCATGLKLARRGHRTLVLSADPAHTLADAFMMPEVAYEPRQITDNLVAQQIDPVTEMSKQYNTILSYMASVFSAKGIDETLAYEIAMLPGMTQLFSLLKIQEVSKTGEFDAVVLDMPASGEALRYLYFPKLVGSIGRKLTGLAGLFSGFAKVFQPLAKIPAPSRSVIQSEMDLIDRLDLLADIIRDSNATSLRLVANPDTFSIENAKRALMSASLYGINVDMAVVNKIMAGSSDAYYDRWASFQHGKVEEAKANFYPLPVKEVQLYATELRGMEMLAKHGDQLFGDEDPAKVFYRGQPYVFEKEDAATIRMTVQVPFSEKDDFAIERYGDSLTVSVKTAAGKIVNIVPLPVATAGMKLAKARLQDKQLLVLFEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVC1</accession>
    <name>A0A075MVC1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701641.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVC1"/>
    <dbReference type="GeneID" id="41598831"/>
    <dbReference type="KEGG" id="nev:NTE_03173"/>
    <dbReference type="HOGENOM" id="CLU_1709040_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="153" mass="16738" checksum="E90075FD22794D84" modified="2014-10-29" version="1">MQPATLGHHNPVGSGLIAVIPPIAGQPRRDPLEIAFVYPSSPPQPRPVIGEAYYFVIDILLLLLSIISGIGLLKRQRWAWFSAIGLFALVIFVHVAASIAVGPDEAGQGFIGTFDSSYGRLASIAISLTGFYLLSRRGVRNYLNNKTITWRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVK8</accession>
    <name>A0A075MVK8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03166</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701635.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVK8"/>
    <dbReference type="GeneID" id="41598824"/>
    <dbReference type="KEGG" id="nev:NTE_03166"/>
    <dbReference type="HOGENOM" id="CLU_1472033_0_0_2"/>
    <dbReference type="OrthoDB" id="5753at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="183" mass="21163" checksum="F3D8CDE617D2AD5C" modified="2014-10-29" version="1">MPLYECNEHQFVENLRRLLEAGEKFIVNRRTTMHDDAKYGPATLPEEEFARYETLCTRKAVNSTVYAKVPFIDVYHGGRMHDAEENLHSSTALKFPRMSIPYFRIEYSVNVWGGTYFFAFDALFDPEIVIEKRSGRRLGKGALVHVLRYNPPKEQVLSVNLPKGVVVLDVKHMVRVIDHTSNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVL6</accession>
    <name>A0A075MVL6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ABC-type multidrug transport system, ATPase and permease component</fullName>
            <ecNumber evidence="12">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NTE_03246</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="12"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701706.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVL6"/>
    <dbReference type="STRING" id="1459636.NTE_03246"/>
    <dbReference type="GeneID" id="41598901"/>
    <dbReference type="KEGG" id="nev:NTE_03246"/>
    <dbReference type="eggNOG" id="arCOG02841">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_1_2"/>
    <dbReference type="OrthoDB" id="24644at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07346">
        <property type="entry name" value="ABC_6TM_exporters"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000221">
        <property type="entry name" value="Multidrug ABC transporter ATP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF1">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="52"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="382"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIF85275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="640" mass="71098" checksum="717E08D2C6BD07D6" modified="2014-10-29" version="1">MMMARMTMTIFRLRRRRAATTTSVENAHQKEPSISAARYVLTHLKKDRLRLIWAVFWSVVFVIIPMQVPILTGTLIDGIHHTAHPRIYGMIDLSSLTPQETVTYAVIGLMVVAGLYGTAAYFRTTSIAKVSRHFVSEIRKTLIQKLEVLSLDIHSKYGSGELLNRALLDTQSLRTFIESSFIKTVVRVVQMSYPILLLFLLDPFLAAIALSVLPAQWLIVSRLQKKLHRTSRRAKKSRARLTTVIKETLDGIETVQTSTAESRSFEKVSSLAEKIESNQVQTQKYVGMITGVVWAFTSFGLALIWWQGGLRVLDGHMTVGNLIQCSGLSLFIYQPYRSFTKAINDYQKGIVAAERIQEILETPSSIQESPDATHLDIQHGSIEFRNVAFSYSLSSSSNSSSSSAAPVHQEEQQRYDQEVLRGIDLKIPAHSLTAIVGRSGSGKSTLLKLVSRLYDPSSGQVLIDDQDIKKIKLDSLRSQIAVVPQTPFIFSGTISENIKLAKPDATDEELRQACESADCLHFILKQKKGFETRLGQGGISLSGGQAQRIAIARALIRRPVILLLDEPSSALDSESESAIMATLYNLKSTITIILVGHHLKAISKADRLVVMNDGKIVQDGTHTELISSQGLYNMLYVEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVN0</accession>
    <name>A0A075MVN0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03271</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701730.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVN0"/>
    <dbReference type="STRING" id="1459636.NTE_03271"/>
    <dbReference type="GeneID" id="41598926"/>
    <dbReference type="KEGG" id="nev:NTE_03271"/>
    <dbReference type="HOGENOM" id="CLU_635547_0_0_2"/>
    <dbReference type="OrthoDB" id="386129at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="431" mass="48921" checksum="E9D1AEA247502699" modified="2014-10-29" version="1">MVPVFILGNQIMVSIAVNKVFLMPKSSASVARESYQQHLESLDYLKKILDEEWISKQSQTKPPKLNRKQIDNMSFLRIGTHKHPLVLLIEDAERDLESMLTTNASPTEAILKASKIAESLRILTDNGIARVAEKIESIKNATDDTYQKTIYEIEVGAAYLKKGHKVEFVATQHKAGKRTFDLLVDCAIELECKKKDRASNSGKRNKDYWTTIATRANKLMTYLGLNYMIIIKTLLNLEEEDMEFISKKLDELIRAKKEGSFSYLEKGVSIFLTRTGEKDQDIEATELEFRTSEPLDFTIGPKGELMKRDDGKTYWRNTRFFGFKTSHLRDRAGSVIDSIADASGQFSGTRPAIIYIDLNIFMASDLEKDLQVIIPMIMAILAKTTSIAAVVITNEVLTEDRQKITFIKRILINENAKHRLPESFGIPEDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVY9</accession>
    <name>A0A075MVY9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03392</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701833.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVY9"/>
    <dbReference type="STRING" id="1459636.NTE_03392"/>
    <dbReference type="GeneID" id="41599038"/>
    <dbReference type="KEGG" id="nev:NTE_03392"/>
    <dbReference type="HOGENOM" id="CLU_2949095_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="59" mass="6663" checksum="4D91EDD14579FA90" modified="2014-10-29" version="1">MATKIRIIFELTCQCGKCSSDLKHFKAHVKDCREFKSLPPKLQGLFETLIHSAGEMAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MW55</accession>
    <name>A0A075MW55_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dehydrogenase, PQQ-dependent, s-GDH family</fullName>
            <ecNumber evidence="3">1.1.5.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_03457</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.5.2" evidence="3"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MW55"/>
    <dbReference type="STRING" id="1459636.NTE_03457"/>
    <dbReference type="KEGG" id="nev:NTE_03457"/>
    <dbReference type="eggNOG" id="arCOG02796">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012253_4_1_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008876">
        <property type="term" value="F:quinoprotein glucose dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012938">
        <property type="entry name" value="Glc/Sorbosone_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH_b-prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019893">
        <property type="entry name" value="SndH-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03606">
        <property type="entry name" value="non_repeat_PQQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19328">
        <property type="entry name" value="HEDGEHOG-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19328:SF13">
        <property type="entry name" value="HIPL1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07995">
        <property type="entry name" value="GSDH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="Soluble quinoprotein glucose dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose/Sorbosone dehydrogenase" evidence="2">
        <location>
            <begin position="77"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose/Sorbosone dehydrogenase" evidence="2">
        <location>
            <begin position="393"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF85485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="505" mass="55291" checksum="7D3754812820D332" modified="2014-10-29" version="1">MPNSKLRTGMAVTFGLIVLLSLMPTILGTFRPTALAQPIPPPSGSNQNATDMQAGAGEPRLPTQDGFTIRVLASNFSAPYNILYGPDGALWITERTGKNITRVDPNNGLRLNSMSVPGVYQSAGQDGLMGMAFDPEFNSTRHIFVAYTYANETAEEVDRRTKITRFTYDSGTGTIKDPVDLIRGLPASIDHNSGRMTFGPDGKLYYTIGDQGNNQFTRYCLNIRAQALPTAEQVASHDWSTYQGKVLRINPDGSIPEDNPQINGVRSHIFTYGHRNAQGIAVGPDGDLYAVEHGPNSDDEFNHLRAGGNFGWPYIAGFQDDKAYRYMNWSAADNCQDLSWTQTGPAPEGVPVMNESDFKAENLVEPIATFYTVETGYNFTNPACGELRSVCFPTVAPSSLHMYSFDKIPDWNGTFLMTTLKSGRIFHLVLNENGTALAGEPQELFRSENRYRDLAFGPDGRTIYVITDSFGFAQNLEGGATTSLWTPGALIEFKYIGQGNGSPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MW61</accession>
    <name>A0A075MW61_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03462</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701887.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MW61"/>
    <dbReference type="STRING" id="1459636.NTE_03462"/>
    <dbReference type="GeneID" id="41599096"/>
    <dbReference type="KEGG" id="nev:NTE_03462"/>
    <dbReference type="HOGENOM" id="CLU_2695536_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="73" mass="7905" checksum="044473194AD2FA9E" modified="2014-10-29" version="1">MPRYLDPIGNNSTTRSQDNALICLIPPLLTKSQNNLSPVNLPIFPVGDGKILIKNIAKAYDIGSKQEGEEAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MW75</accession>
    <name>A0A075MW75_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701806.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MW75"/>
    <dbReference type="GeneID" id="41599011"/>
    <dbReference type="KEGG" id="nev:NTE_03365"/>
    <dbReference type="eggNOG" id="arCOG14335">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1631561_0_0_2"/>
    <dbReference type="OrthoDB" id="3301at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="162" mass="18040" checksum="2CE66713EE215BD0" modified="2014-10-29" version="1">MASLTFLAFTVTIASIHFQTANAECLRDEDWPEKPCFDVGSSAPSDAELRQIWNKYYEMKGQAWMEMKKAEMDKAINDGTFGDWLSDPVKGSANKNVYAYYRVYDAVPNMVLDPYSGNYVVQGSEPPRGEWYTSTMGIAAIIGMGAVAAVASFFVFRKAGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MW92</accession>
    <name>A0A075MW92_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Elongator complex protein 3</fullName>
            <ecNumber evidence="15">2.3.1.311</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">tRNA uridine(34) acetyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">NTE_02879</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>uridine(34) in tRNA + acetyl-CoA + S-adenosyl-L-methionine + H2O = 5-(carboxymethyl)uridine(34) in tRNA + 5'-deoxyadenosine + L-methionine + CoA + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:61020"/>
            <dbReference type="Rhea" id="RHEA-COMP:10407"/>
            <dbReference type="Rhea" id="RHEA-COMP:11727"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74882"/>
            <dbReference type="EC" id="2.3.1.311"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:61021"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="17">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ELP3 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.311" evidence="15"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987013.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MW92"/>
    <dbReference type="STRING" id="1459636.NTE_02879"/>
    <dbReference type="GeneID" id="41598559"/>
    <dbReference type="KEGG" id="nev:NTE_02879"/>
    <dbReference type="eggNOG" id="arCOG01361">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025983_2_1_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106261">
        <property type="term" value="F:tRNA uridine(34) acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002926">
        <property type="term" value="P:tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="entry name" value="tm_1862 like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039661">
        <property type="entry name" value="ELP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034687">
        <property type="entry name" value="ELP3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056591">
        <property type="entry name" value="ELP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032432">
        <property type="entry name" value="Radical_SAM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01211">
        <property type="entry name" value="ELP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135:SF0">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23613">
        <property type="entry name" value="ELP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16199">
        <property type="entry name" value="Radical_SAM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005669">
        <property type="entry name" value="Hist_AcTrfase_ELP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01082">
        <property type="entry name" value="B12-binding_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01086">
        <property type="entry name" value="elongater_protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00344">
        <property type="entry name" value="ELP3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="13 19" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="11 17" id="KW-0408">Iron</keyword>
    <keyword evidence="12 17" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="5" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Radical SAM core" evidence="18">
        <location>
            <begin position="79"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR005669-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="AIF84917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="534" mass="59906" checksum="84E85D1790371459" modified="2014-10-29" version="1">MLATAADSDPNYQQACRTIAALIAEKQSSLLLSAGEVRQIVRDVASSFHLSTMPKNEHIISYLPRGSRYRKLLMVKPAKTASGVAVIAVMPKPYECPHGKCIYCPGGIEFNTPLSYTGTEPATRAAQKFQFDPYEQVSSKMKQLQARGHDTGKSEIVIVGGTFPFMPEDYQREFAKSCYDALNGSRSQSLQDAIAANERAENRCVGFTVETKPDYCKEPHVNLMLELGVTRVEIGVQSLDNKVYRLVNRGHTLDDVIDAFRIARDSGYKIVAHMMPGLPGSSPDKDIADFKRLFEDEAFKPDMLKVYPTLVLEHTGLYQLYNAGKYHAYSDDDLVSVIVEMKKMVPQYVRIMRVQREIESDDIMAGPKSGNLRQIVLARLKREGHNCACIRCREAGLQRRYPAEDEVVMKRADYAASGGREIFLSYESADSETILGFLRLRKVNRPHRQELQDDAAIVRELHVYGQALGVGLEADSSSYQHRGYGMKLMQEAERIARDELGAKKIAVISAVGTREYYKTRLGYRQDGPYVSKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWH7</accession>
    <name>A0A075MWH7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01566</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385235.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWH7"/>
    <dbReference type="GeneID" id="43502614"/>
    <dbReference type="KEGG" id="nev:NTE_01566"/>
    <dbReference type="HOGENOM" id="CLU_198711_0_0_2"/>
    <dbReference type="OrthoDB" id="7737at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036648">
        <property type="entry name" value="CN_Hdrase_a/SCN_Hdrase_g_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56209">
        <property type="entry name" value="Nitrile hydratase alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="58" mass="6600" checksum="2C0C0F9A55DF16D7" modified="2014-10-29" version="1">MEPKEKEAEIISEILLKAASEPEFRNSLIRDPAAVLEMYNVSPQAKMVIKRTIIDLTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWM8</accession>
    <name>A0A075MWM8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoglycolate phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03017</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.18" evidence="1"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701521.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWM8"/>
    <dbReference type="STRING" id="1459636.NTE_03017"/>
    <dbReference type="GeneID" id="41598687"/>
    <dbReference type="KEGG" id="nev:NTE_03017"/>
    <dbReference type="eggNOG" id="arCOG01213">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044146_2_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008967">
        <property type="term" value="F:phosphoglycolate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1070.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01487">
        <property type="entry name" value="Pglycolate_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01482">
        <property type="entry name" value="SPP-subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10000:SF8">
        <property type="entry name" value="HAD SUPERFAMILY HYDROLASE-LIKE, TYPE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10000">
        <property type="entry name" value="PHOSPHOSERINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="NCBIfam" id="TIGR01487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="238" mass="25896" checksum="BFF72202D8885FE5" modified="2014-10-29" version="1">MADNNIKVFAVDIDGTLTENGGGAVHMPALSKLRYLDKLGYPVIYVTGRSSIEAYVLAVFGGTTRVAVGENGGAITVAPQEHKLLASRERCMAGYELLKKSLDGVQEKPVFPRMTEVVMLRTFDIKEGQKILDEHGLQLYLNDSKYAFHINEKGVDKALGLREALKILKAEPEETVAIGDSETDIPMYDICGCSIALAHAEDNVKEKAKHVVAGREGTGLIDAIDYVAQNYLGVKAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWW2</accession>
    <name>A0A075MWW2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nicotinate-nucleotide pyrophosphorylase [carboxylating]</fullName>
            <ecNumber evidence="9">2.4.2.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Quinolinate phosphoribosyltransferase [decarboxylating]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NTE_01703</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Involved in the catabolism of quinolinic acid (QA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>nicotinate beta-D-ribonucleotide + CO2 + diphosphate = quinolinate + 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12733"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29959"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from quinolinate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 9">Hexamer formed by 3 homodimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the NadC/ModD family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.19" evidence="9"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700474.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWW2"/>
    <dbReference type="STRING" id="1459636.NTE_01703"/>
    <dbReference type="GeneID" id="41597473"/>
    <dbReference type="KEGG" id="nev:NTE_01703"/>
    <dbReference type="eggNOG" id="arCOG01482">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039622_2_0_2"/>
    <dbReference type="OrthoDB" id="115072at2157"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00331"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034213">
        <property type="term" value="P:quinolinate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01572">
        <property type="entry name" value="QPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.20:FF:000001">
        <property type="entry name" value="Nicotinate-nucleotide diphosphorylase (Carboxylating)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000030">
        <property type="entry name" value="Nicotinate-nucleotide pyrophosphorylase, carboxylating"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.20">
        <property type="entry name" value="Quinolinate phosphoribosyl transferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004393">
        <property type="entry name" value="NadC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027277">
        <property type="entry name" value="NadC/ModD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037128">
        <property type="entry name" value="Quinolinate_PRibosylTase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002638">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022412">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00078">
        <property type="entry name" value="nadC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32179">
        <property type="entry name" value="NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE [CARBOXYLATING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32179:SF3">
        <property type="entry name" value="NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE [CARBOXYLATING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01729">
        <property type="entry name" value="QRPTase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02749">
        <property type="entry name" value="QRPTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006250">
        <property type="entry name" value="NadC_ModD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54675">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 9" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Quinolinate phosphoribosyl transferase N-terminal" evidence="11">
        <location>
            <begin position="27"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Quinolinate phosphoribosyl transferase C-terminal" evidence="10">
        <location>
            <begin position="113"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR006250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIF83764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="290" mass="31087" checksum="E6B3AB28038F67E3" modified="2014-10-29" version="1">MPASLDTVLDIRQALASFIQEDVGTGDITSNTTVPADRNAKAEIVCKTGNAVVCGLEEAGIIFEMCGCSARALVRDGSRASKGKRVMIIEGNARAILKAERVALNLIMRMSGIATETRALADKAKPVKIAATRKTAPGLRYFDKKAVVIGRGLAHRMRLDDMVLIKDNHIALAGGEPDKCVRLAREGAGTAIKVECEAKSEKEAIVAIRAGADIVMLDNFTPAQAAKTIRNLAKLGLRKKTIIEISGGVNHKNIKQYAKAKPDYVSMGYITHSPKAVDFSLEIMTAKTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MX13</accession>
    <name>A0A075MX13_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glycosyl transferase</fullName>
            <ecNumber evidence="9">2.4.1.212</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NTE_03155</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NodC/HAS family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.212" evidence="9"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MX13"/>
    <dbReference type="STRING" id="1459636.NTE_03155"/>
    <dbReference type="KEGG" id="nev:NTE_03155"/>
    <dbReference type="eggNOG" id="arCOG01389">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029695_1_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050501">
        <property type="term" value="F:hyaluronan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085029">
        <property type="term" value="P:extracellular matrix assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030213">
        <property type="term" value="P:hyaluronan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06423">
        <property type="entry name" value="CESA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22913">
        <property type="entry name" value="HYALURONAN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22913:SF12">
        <property type="entry name" value="MANNURONAN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="385"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="413"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="451"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="8">
        <location>
            <begin position="104"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF85187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="479" mass="54582" checksum="5EB402F2E9BA1199" modified="2014-10-29" version="1">MESIGMMDAAQGDALAKTLSQKCQQRVNSSGRIQVSKKAWAVRIITIVATLILISFTIQLGITLQDPFVTAGIIVPAHSLAYLIIGWLLFKSPATGTPGNDLVSVIVPVYNQKGMIELVIDAIYRSTYRNIEVIAVNDGSKDGTAEILDGLVKKYPTLKVIHKKNEGKRKAVASAFYNSRGRYLVLIDSDSVVEEHAVMELMKAFKADERVGGVVGFAKVWNADKNILTRCQDVWYDYSFNIRKCAESYFGSVMCLSGCLAAYRREAIADYIPYWINARLKDSEDRELTTYVITPPKAKPLMTPGTKKVMQWMSRYDDAEDRGLTGQALVDWKAVYAPSAIVYTDVPENFKVFLRQQKRWKKGTLRVSFFVSGFFWRRNPIMSFLLFYVEFMLMFTNPLILLLAFVWEPVFLNNYWVPVIFFIGSLLTSLGHGADYKFRDRTSKTWFYKPLMNMITAFVISWIIFPAIWSLRKNEWGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MX26</accession>
    <name>A0A075MX26_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701634.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MX26"/>
    <dbReference type="GeneID" id="41598823"/>
    <dbReference type="KEGG" id="nev:NTE_03165"/>
    <dbReference type="HOGENOM" id="CLU_1340767_0_0_2"/>
    <dbReference type="OrthoDB" id="6320at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="194" mass="22081" checksum="7CD80C5CD4E5EA9C" modified="2014-10-29" version="1">MPVLSDSYMGLFMPADIPSRITRFIAGQADFPYIKREETIGAFFIFGKDGGVHGDSEVGEARDLAKRTVEQAAKDIRMYASMPGRLDSAFTRENYTKRMLQIAVDSRGLKQEEINERVAGDPTILSDCFAQHVAFYKQEFYFEIFGPLKKYQLPPSLQQRMESRMILLGYNAKNARALPFANSLEAFFAWLKSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MX30</accession>
    <name>A0A075MX30_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01778</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700538.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MX30"/>
    <dbReference type="STRING" id="1459636.NTE_01778"/>
    <dbReference type="GeneID" id="41597545"/>
    <dbReference type="KEGG" id="nev:NTE_01778"/>
    <dbReference type="HOGENOM" id="CLU_2747967_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="70" mass="7086" checksum="D29677D871D2F4A5" modified="2014-10-29" version="1">MSKYNTNANKITASKVVAAVATGALIFGTAYGAATLHTPLGAPILTASVFSLGLLMGTTFKGKRKAEVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MXA5</accession>
    <name>A0A075MXA5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01874</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MXA5"/>
    <dbReference type="KEGG" id="nev:NTE_01874"/>
    <dbReference type="HOGENOM" id="CLU_2447522_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="89" mass="10536" checksum="B364FED1183D4B57" modified="2014-10-29" version="1">MLAPKYSSFFHNMLYIIIISRLVKCGLWIIGWYQKNNACAHQILWERKNLQMQRQKGSKMNGHCDTLNPLEGNSCVFYHLSAEFKEVHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MXH8</accession>
    <name>A0A075MXH8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11 12">Chorismate synthase</fullName>
            <shortName evidence="11">CS</shortName>
            <ecNumber evidence="3 11 12">4.2.3.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">5-enolpyruvylshikimate-3-phosphate phospholyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">aroC</name>
        <name evidence="14" type="ORF">NTE_01951</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 13">
            <text>5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21020"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="EC" id="4.2.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 13">
            <name>FMNH2</name>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
        </cofactor>
        <text evidence="11 13">Reduced FMN (FMNH(2)).</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 11 13">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 13">Belongs to the chorismate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.5" evidence="3 11 12"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700666.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MXH8"/>
    <dbReference type="STRING" id="1459636.NTE_01951"/>
    <dbReference type="GeneID" id="41597698"/>
    <dbReference type="KEGG" id="nev:NTE_01951"/>
    <dbReference type="eggNOG" id="arCOG04133">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034547_0_2_2"/>
    <dbReference type="OrthoDB" id="33049at2157"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004107">
        <property type="term" value="F:chorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07304">
        <property type="entry name" value="Chorismate_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.150.10:FF:000002">
        <property type="entry name" value="Chorismate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.150.10">
        <property type="entry name" value="Chorismate synthase AroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00300">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000453">
        <property type="entry name" value="Chorismate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035904">
        <property type="entry name" value="Chorismate_synth_AroC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020541">
        <property type="entry name" value="Chorismate_synthase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00033">
        <property type="entry name" value="aroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003793">
        <property type="entry name" value="PRK05382.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085">
        <property type="entry name" value="CHORISMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085:SF0">
        <property type="entry name" value="CHORISMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01264">
        <property type="entry name" value="Chorismate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001456">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103263">
        <property type="entry name" value="Chorismate synthase, AroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00787">
        <property type="entry name" value="CHORISMATE_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00788">
        <property type="entry name" value="CHORISMATE_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00789">
        <property type="entry name" value="CHORISMATE_SYNTHASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11 13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 11 13" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7 11" id="KW-0274">FAD</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 11" id="KW-0288">FMN</keyword>
    <keyword evidence="10 11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 11" id="KW-0521">NADP</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="127"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="305"/>
            <end position="309"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="NCBIfam" id="TIGR00033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AIF84009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="373" mass="39374" checksum="73887EAADB041603" modified="2014-10-29" version="1">MVGGNIIGERFVAVSFGESHGRCVGMLVDGCPAGLLLSEDDIQGQLDRRKPGQSAVTTQRKEEDRVEILSGVFNGFTTGAPICMLIWNKDADSRAYEAIKNIPRPGHADYPAMVKYGGFADYRGSGRFSGRLTATLVMAGAVAQKLLKETLGIETVAYTSEIGGIKAAGNNITAENIARRYDNDVRCPDPAAAEKMRDAILAARRDGDSLGGVVECTTSNLPVGLGEPIFASLEADLSKALFGIPAVKAVEFGSGFEGSKRRGSENNDAYYIKNDGKIVTRTNNSGGILGGLSNGMPLIVRVAFKPAASIAKSQDTLDISTKSQARLTVPGRHDPCVVPRAPPIVECVVSMVLADHAIRAGLVPPVLKKKGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MYI2</accession>
    <name>A0A075MYI2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02275</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700924.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MYI2"/>
    <dbReference type="STRING" id="1459636.NTE_02275"/>
    <dbReference type="GeneID" id="41597990"/>
    <dbReference type="KEGG" id="nev:NTE_02275"/>
    <dbReference type="eggNOG" id="arCOG06055">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2204197_0_0_2"/>
    <dbReference type="OrthoDB" id="55755at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="108" mass="12143" checksum="5F4741328051C8F2" modified="2014-10-29" version="1">MKFEYEEFGTIEDVFLYLVSVAPYGKQVMPISSYKGYVFSLIPLSPLTGELLMMVYTKGNLDAGLVEFDVSTKKFRMVPAVERADRNYFIVLTPKTATLADEAINGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MZG6</accession>
    <name>A0A075MZG6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">3-methyl-2-oxobutanoate hydroxymethyltransferase</fullName>
            <ecNumber evidence="5">2.1.2.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ketopantoate hydroxymethyltransferase</fullName>
            <shortName evidence="5">KPHMT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">panB</name>
        <name evidence="10" type="ORF">NTE_02601</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = 2-dehydropantoate + (6S)-5,6,7,8-tetrahydrofolate</text>
            <dbReference type="Rhea" id="RHEA:11824"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5 8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 1/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; coenzyme A biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodecamer; pentamer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the PanB family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.11" evidence="5"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701178.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MZG6"/>
    <dbReference type="STRING" id="1459636.NTE_02601"/>
    <dbReference type="GeneID" id="41598294"/>
    <dbReference type="KEGG" id="nev:NTE_02601"/>
    <dbReference type="eggNOG" id="arCOG00584">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036645_1_0_2"/>
    <dbReference type="OrthoDB" id="8414at2157"/>
    <dbReference type="UniPathway" id="UPA00241"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003864">
        <property type="term" value="F:3-methyl-2-oxobutanoate hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06557">
        <property type="entry name" value="KPHMT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000003">
        <property type="entry name" value="3-methyl-2-oxobutanoate hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00156">
        <property type="entry name" value="PanB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003700">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00222">
        <property type="entry name" value="panB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001452">
        <property type="entry name" value="PRK00311.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881">
        <property type="entry name" value="3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881:SF0">
        <property type="entry name" value="3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02548">
        <property type="entry name" value="Pantoate_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000388">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5 6">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <begin position="59"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>3-methyl-2-oxobutanoate</name>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>3-methyl-2-oxobutanoate</name>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>3-methyl-2-oxobutanoate</name>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000388-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000388-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000388-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIF84644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="295" mass="31579" checksum="C9AADD2561590348" modified="2014-10-29" version="1">MTQEAATSSAPKKNKKVSVSDLALLKSEGKEKISVLTAYDYSTALICDRAGVDVLLVGDSAGMVVLGHPSTVPVNMQEMLMFCGAVSRGAKRAMIIGDMPFGSYQPSTSMAIENAVQFIKGGCDAVKLEGGAEIADKVKAIVDAGVPVMGHIGLKPQTSSLWEGYRLQGRTAESAQRLVQDAQALEKAGVFSIVLEMVASEVAEVITRKVSVPTIGIGSGPECDGQVLVLHDLLGIYEDIKPKFVKRYAELAKPILDAVSSYTRDVKAGKFPDEQNTFHMNPEELEKFQGKGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N088</accession>
    <name>A0A075N088_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02876</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701406.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N088"/>
    <dbReference type="STRING" id="1459636.NTE_02876"/>
    <dbReference type="GeneID" id="41598556"/>
    <dbReference type="KEGG" id="nev:NTE_02876"/>
    <dbReference type="HOGENOM" id="CLU_1754605_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="148" mass="16096" checksum="51216C228DFC4215" modified="2014-10-29" version="1">MIDKIVLAMALGLAAIVSLILASQFLPIQITIANNDVGSWQSMSAGASCIDSGCGERIIRNCEAPNKIAILRENGRAWVITVEGVTNDSCKIIMLDTALQNYNSRFADFTMYECLVSMTELSSELRGDSFDQLVSNIIDRDRCGVSVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N0E2</accession>
    <name>A0A075N0E2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">phosphoribosylglycinamide formyltransferase 1</fullName>
            <ecNumber evidence="2">2.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">5'-phosphoribosylglycinamide transformylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">GAR transformylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NTE_02921</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(1)-(5-phospho-beta-D-ribosyl)glycinamide + (6R)-10-formyltetrahydrofolate = N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + (6S)-5,6,7,8-tetrahydrofolate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15053"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="EC" id="2.1.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the GART family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.2" evidence="2"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701443.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N0E2"/>
    <dbReference type="STRING" id="1459636.NTE_02921"/>
    <dbReference type="GeneID" id="41598599"/>
    <dbReference type="KEGG" id="nev:NTE_02921"/>
    <dbReference type="eggNOG" id="arCOG02825">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038395_1_0_2"/>
    <dbReference type="OrthoDB" id="27277at2157"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00126"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004644">
        <property type="term" value="F:phosphoribosylglycinamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd08645">
        <property type="entry name" value="FMT_core_GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.170">
        <property type="entry name" value="Formyl transferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01930">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004607">
        <property type="entry name" value="GART"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001555">
        <property type="entry name" value="GART_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00639">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43369">
        <property type="entry name" value="PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43369:SF2">
        <property type="entry name" value="PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="Formyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00373">
        <property type="entry name" value="GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl transferase N-terminal" evidence="9">
        <location>
            <begin position="7"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIF84959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="206" mass="22394" checksum="E2471406B980B9FC" modified="2014-10-29" version="1">MTTNLGILISGRGSNMDAILAAIKAGRIPSARPRIVISNKPDAAGLKTASEKYGVPTKVIPSEGLKGWDYDKKLVAALEEAGVTPENGLVCLAGFMRIISPEFVRHFKMRILNIHPALLPSFPGLHAQRQAVDYGVKVSGCTVHFVDEGVDSGPVILQRTVPVMEGDTEETLSARILEQEHQAYQEAVRLFAEGRLKVEGRKVRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N0R2</accession>
    <name>A0A075N0R2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF192 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03024</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N0R2"/>
    <dbReference type="STRING" id="1459636.NTE_03024"/>
    <dbReference type="KEGG" id="nev:NTE_03024"/>
    <dbReference type="eggNOG" id="arCOG03116">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097039_2_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1140">
        <property type="entry name" value="Protein of unknown function DUF192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003795">
        <property type="entry name" value="DUF192"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038695">
        <property type="entry name" value="Saro_0823-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37953">
        <property type="entry name" value="UPF0127 PROTEIN MJ1496"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37953:SF1">
        <property type="entry name" value="UPF0127 PROTEIN MJ1496"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02643">
        <property type="entry name" value="DUF192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="178" mass="19279" checksum="31548757CEBB3D97" modified="2014-10-29" version="1">MLFVVQATRLAIAIGAAAAAGAIAFAVLYFTPALRMVEGTPDNISAVAGAGLPGYNHTVVSIADARILADIADTPDKKTKGLAVRSNMTEGEGMLFLFDNDYPHPFWMNGMKFPIDIIWLDSNKTVVHIEHSLPPCPNQFDCPNHQPDHNARYVLETVAGFSERHGVKDGTQAQFSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N1R3</accession>
    <name>A0A075N1R3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_03371</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N1R3"/>
    <dbReference type="STRING" id="1459636.NTE_03371"/>
    <dbReference type="KEGG" id="nev:NTE_03371"/>
    <dbReference type="eggNOG" id="arCOG04793">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_680785_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018547">
        <property type="entry name" value="AbiEi_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048301">
        <property type="entry name" value="NucS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09407">
        <property type="entry name" value="AbiEi_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01939">
        <property type="entry name" value="NucS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease NucS C-terminal" evidence="1">
        <location>
            <begin position="28"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="AbiEi antitoxin C-terminal" evidence="2">
        <location>
            <begin position="224"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF85399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="404" mass="46239" checksum="4691F3B2A959D7C1" modified="2014-10-29" version="1">MCAMHIATSHPESTISDLLRSLTGNAKVTIEREAKIANIGTLDYRLRDEHGQEYFVEVKSRRITKLDVGQLATYATLLHKKIPSAKLVLIAKKVDSIHKEVLKEIGVEVIELEHNLSNSNQTLRIIPSKRINKKLELSPKEQESYFLLLRKGIVVVTPELLSKELMVPNGYSKNILSSLARKGMLSRFGRGKYVIISPDVVYGRKGYTIDPIVMLEQLVGDEPYYLAYTSALYIHGLSLQLPFETTVAVTKQKRSVKVGHNSIIKFVRIMAEAMFGYKQQRYLNSYTSVSDLEKTIIDCIDRHDLCGGISEVTRILSESLQQIDRDKLLNYLKKFNKQVVIQRLGFILEKLTQEGFEVDPKLLQNMENLKFRHVYRLDFTKPKSGTMSKKWKIIENADCMSWKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N273</accession>
    <name>A0A075N273_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Membrane protease subunit, stomatin/prohibitin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NTE_03516</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701924.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N273"/>
    <dbReference type="STRING" id="1459636.NTE_03516"/>
    <dbReference type="GeneID" id="41599138"/>
    <dbReference type="KEGG" id="nev:NTE_03516"/>
    <dbReference type="eggNOG" id="arCOG01915">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024949_3_3_2"/>
    <dbReference type="OrthoDB" id="10752at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08826">
        <property type="entry name" value="SPFH_eoslipins_u1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000004">
        <property type="entry name" value="Putative membrane protease family, stomatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043202">
        <property type="entry name" value="Band-7_stomatin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264:SF19">
        <property type="entry name" value="AT06885P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264">
        <property type="entry name" value="BAND 7 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="Band 7" evidence="5">
        <location>
            <begin position="46"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="315"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="318"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="349"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF85544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="359" mass="39335" checksum="255BFF0CAAED616B" modified="2014-10-29" version="1">MSTSQLSSLSASSPSLSPSLILEQLALPELIGIGIVVIIFLVVVASSIRIIREYERAIVFRLGRLIGAKGPGLIILIPFIDRALKVDLRVITLDVPKQKIITLDNVTVDVDAVVYLRVSDPSNAVVKVNNYLMASSLLSQTTLRDLIGQTSFDDLLSRREDLNKRMQEILDTATDPWGVKVSSVAIRDVSLPENMHRAIAKQAEAEREKRGRIIIAEGELIAAEKMALAADYYTKNIAALRLRELQTWAEVAREKNMIVVTAGGSGAVGANSGSGDNQRDLGSLLGIIKERTPVAEQVDAERIREIAREELASIISERGGEGERRRPQETKGRTGRNKNHNDNNIINDRTVNSDDLSEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ML32</accession>
    <name>A0A075ML32_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein-tyrosine-phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_00057</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699202.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ML32"/>
    <dbReference type="STRING" id="1459636.NTE_00057"/>
    <dbReference type="GeneID" id="41596008"/>
    <dbReference type="KEGG" id="nev:NTE_00057"/>
    <dbReference type="eggNOG" id="arCOG04425">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071415_3_3_2"/>
    <dbReference type="OrthoDB" id="295776at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046685">
        <property type="term" value="P:response to arsenic-containing substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16345">
        <property type="entry name" value="LMWP_ArsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43428">
        <property type="entry name" value="ARSENATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43428:SF1">
        <property type="entry name" value="ARSENATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="Phosphotyrosine protein phosphatases I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0059">Arsenical resistance</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphotyrosine protein phosphatase I" evidence="2">
        <location>
            <begin position="11"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF82141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="143" mass="16125" checksum="F815F75BD7DBFD03" modified="2014-10-29" version="1">MNDQQQRQQEKTVLFVCVENAGRSQMAEGFFRKYAPKGYRAISAGTRPAQEINPLAVQAMKEAGVDISRQRSKVIDDDMVRGCAVAVNMGCMDKSECPLLFLNNPVDWGIEDPKGKPIEKVRLIRDDIERRVKELVRDLENSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLH1</accession>
    <name>A0A075MLH1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-type Mn2+/Zn2+ transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NTE_00034</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC-3 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987077.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLH1"/>
    <dbReference type="STRING" id="1459636.NTE_00034"/>
    <dbReference type="GeneID" id="41595986"/>
    <dbReference type="KEGG" id="nev:NTE_00034"/>
    <dbReference type="eggNOG" id="arCOG01006">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028808_3_1_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="entry name" value="ABC transporter involved in vitamin B12 uptake, BtuC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001626">
        <property type="entry name" value="ABC_TroCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30477">
        <property type="entry name" value="ABC-TRANSPORTER METAL-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30477:SF0">
        <property type="entry name" value="METAL TRANSPORT SYSTEM MEMBRANE PROTEIN TM_0125-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00950">
        <property type="entry name" value="ABC-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="ABC transporter involved in vitamin B12 uptake, BtuC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF82118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="291" mass="30001" checksum="45CC25415922B920" modified="2014-10-29" version="1">MALEILEFGFMQRALIAGVAVAITTSVIGLFLVLRRNSLFGDALSHVAFGGIAVGLVAGIYPLWTGLALSIAGALGITKLRQSAKIPADATVAILLSSGLALGILLVSASGGFTLDLFSFLFGSILLVSVNDTLAILALAGVILAIIVTLHKKFMYITFDEEQARVSGLPISKLNYLFVVLASVAAVVSMRLVGILLVSALIVIPNVTALLFGRGFKKTALISVAVSVFSVLTGIAVSYAFNLAPAGTIVLVSAAVFVAALAGRQTMAVKRRQAAASAEAATAPAEEISRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLH8</accession>
    <name>A0A075MLH8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00234</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699326.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLH8"/>
    <dbReference type="STRING" id="1459636.NTE_00234"/>
    <dbReference type="GeneID" id="41596152"/>
    <dbReference type="KEGG" id="nev:NTE_00234"/>
    <dbReference type="eggNOG" id="arCOG01245">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2067694_0_0_2"/>
    <dbReference type="OrthoDB" id="10001at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="118" mass="13620" checksum="D35873E0A5237465" modified="2014-10-29" version="1">MMLAENDGIIIKDWREFWMGHKGSIEAVYTVNKGLPEDVIERMRSAYAKAAEKYLITSKNHDHSFDKLREETNKRFLQISGFSDKQIQDIVKEHGDLGTISDEKYRSSSPAITNKLWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLL6</accession>
    <name>A0A075MLL6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ORC1-type DNA replication protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NTE_00084</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in regulation of DNA replication.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the CDC6/cdc18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699221.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLL6"/>
    <dbReference type="STRING" id="1459636.NTE_00084"/>
    <dbReference type="GeneID" id="41596032"/>
    <dbReference type="KEGG" id="nev:NTE_00084"/>
    <dbReference type="eggNOG" id="arCOG00467">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025112_3_1_2"/>
    <dbReference type="OrthoDB" id="195574at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08768">
        <property type="entry name" value="Cdc6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18139">
        <property type="entry name" value="HLD_clamp_RarA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000073">
        <property type="entry name" value="ORC1-type DNA replication protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01407">
        <property type="entry name" value="ORC1_type_DNA_replic_protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049945">
        <property type="entry name" value="AAA_22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015163">
        <property type="entry name" value="Cdc6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055237">
        <property type="entry name" value="Cdc6_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050311">
        <property type="entry name" value="ORC1/CDC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014277">
        <property type="entry name" value="Orc1/Cdc6_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02928">
        <property type="entry name" value="orc1/cdc6 family replication initiation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763:SF26">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13401">
        <property type="entry name" value="AAA_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22703">
        <property type="entry name" value="Cdc6_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09079">
        <property type="entry name" value="WHD_Cdc6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01074">
        <property type="entry name" value="Cdc6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="57"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc6 C-terminal" evidence="7">
        <location>
            <begin position="311"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="69"/>
            <end position="73"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF82168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="403" mass="44676" checksum="8BF50CC347504B38" modified="2014-10-29" version="1">MSSGDIDNIFDRAASGKSLVKKRETLTIDYVPEKLPFRDREATALAQTLSTVFKGARPSNLLLFGKPGTGKTAVVRTVVDRLKKKSGELGITVNVPIINAKLANSAYKMLFEIAENLGLNKEEKKVVHFTGLSMGEATDRILQFIQNKKMHVILVIDEIDSLVDRNGDDVLYSFTRANERMGKGGFVSLIGISNSLTFKDKLDPRVRSSLSEEETVFNPYTVEQLRQILSERARLAFNEGAITDAAINLCAAMAGREHGDARKAIDLLRVAAELAEREHVLKVEEKHVRAAQEKIEKDTNLEVIRNATTHTKFVMLAITKSKNGNTGEVYETYSSLCKQVEQEPLTQRRVTQIISELDQLGLVSTDVVSQGRYGRSQKIKVAVPLATVQDALKDDPTFSDLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLP7</accession>
    <name>A0A075MLP7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protease HtpX homolog</fullName>
            <ecNumber evidence="11">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">htpX</name>
        <name evidence="13" type="ORF">NTE_00121</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SR1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the peptidase M48B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="11"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLP7"/>
    <dbReference type="STRING" id="1459636.NTE_00121"/>
    <dbReference type="KEGG" id="nev:NTE_00121"/>
    <dbReference type="eggNOG" id="arCOG01331">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042266_0_2_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.10">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00188">
        <property type="entry name" value="Pept_M48_protease_HtpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050083">
        <property type="entry name" value="HtpX_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022919">
        <property type="entry name" value="Pept_M48_protease_HtpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002669">
        <property type="entry name" value="PRK02391.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43221">
        <property type="entry name" value="PROTEASE HTPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43221:SF2">
        <property type="entry name" value="PROTEASE HTPX HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 11 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 11" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0346">Stress response</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 11" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M48" evidence="12">
        <location>
            <begin position="62"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIF82203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="290" mass="31611" checksum="2547359DEBAA50C5" modified="2014-10-29" version="1">MILSFAILSVLYLVFLGVLAYLGVGYIPIAIIASLMVLAQWYFSDKIVLWSSGAKVVTKDQYPRLHAIVERLAAENGLPMPKIAVMNTQVPNAFATGKSPKSAVVAVTAGIMNTLDDDELEGVLAHELTHVRNRDVLVITLASLFSIVAFSLMRFGLFSSMFYGGGYGYYGGGRNSNNGAGAMVIIIVVAAVTWLVSFLIIRAISRYREFAADKGSAQMTRKPEKLASALLKISGKMKAAPQRELEQAASLNTFFIIPALSKSSLSNLFSTHPPVEERVRRLMEMQSLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLV9</accession>
    <name>A0A075MLV9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00141</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLV9"/>
    <dbReference type="STRING" id="1459636.NTE_00141"/>
    <dbReference type="KEGG" id="nev:NTE_00141"/>
    <dbReference type="HOGENOM" id="CLU_2662136_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="75" mass="8428" checksum="00488B6CA3F8BB5E" modified="2014-10-29" version="1">MENVGSKGIMYMDSICTCKTCNHKLTKNCIEASCSCCTEENHSMVLDGIEGFAPLTNKKEKKEAKRNARAQKRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MM35</accession>
    <name>A0A075MM35_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Family 3 adenylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00469</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699501.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MM35"/>
    <dbReference type="STRING" id="1459636.NTE_00469"/>
    <dbReference type="GeneID" id="41596344"/>
    <dbReference type="KEGG" id="nev:NTE_00469"/>
    <dbReference type="eggNOG" id="arCOG07810">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057456_0_0_2"/>
    <dbReference type="OrthoDB" id="9201at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009190">
        <property type="term" value="P:cyclic nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050697">
        <property type="entry name" value="Adenylyl/Guanylyl_Cyclase_3/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43081:SF1">
        <property type="entry name" value="ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43081">
        <property type="entry name" value="ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="1">
        <location>
            <begin position="121"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="323" mass="36008" checksum="FFE7369C3FE3ED82" modified="2014-10-29" version="1">MQSKLKQTVFNLYNAGIFPEVIATQLDISEEEVNRIIKDRISKEAEEEKEKTSVKQTSSSSFDRALLGMFYLDAVVNIGNIIKSAQLAMWNSLKGEMEFNISDEDTRDILEKMAGSKATFVILYIDIVGSTKLSMTLPADKLAAIVRGFTYEISLVVSAYGGFVLKYLGDAILAFFVIPDKSNPYMPCTNAVHCARSMIRAVKEGFNVILNQEGYSELDVRIGIDLGENVVVEYGWDLHSLVMDGKQITIRKVRHDILGYTISIASKITGLAQPNQIVIGQYVYEELDKQQKDAFKLLSTPPETWSYVGSKTGNLYSLYASSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MM43</accession>
    <name>A0A075MM43_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved protein implicated in secretion</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699235.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MM43"/>
    <dbReference type="STRING" id="1459636.NTE_00108"/>
    <dbReference type="GeneID" id="41596050"/>
    <dbReference type="KEGG" id="nev:NTE_00108"/>
    <dbReference type="eggNOG" id="arCOG00452">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1324054_0_0_2"/>
    <dbReference type="OrthoDB" id="9831at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="203" mass="22340" checksum="213A6746837660E4" modified="2014-10-29" version="1">MVERQQLVNQLNNATAVVYNQLGRLQMLDKRFASMESLYMQQITTSIKTGNNPRARILANELSNVKKLRRTTQHTGMALEALVIRFSTMNEFAMILDTIDPTVDMIKGIQAELSKAIPAAGDALSEVSSVTADMLASANVRAADAKISTPMDADALSILNEIEGALETEAKAKLPEIPADMPTHRQEEKEEGEKQQQQEEVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMA3</accession>
    <name>A0A075MMA3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Glycosyl transferase</fullName>
            <ecNumber evidence="10">2.4.1.212</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NTE_00306</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NodC/HAS family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.212" evidence="10"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987104.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMA3"/>
    <dbReference type="STRING" id="1459636.NTE_00306"/>
    <dbReference type="GeneID" id="41596210"/>
    <dbReference type="KEGG" id="nev:NTE_00306"/>
    <dbReference type="eggNOG" id="arCOG01389">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029695_1_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050501">
        <property type="term" value="F:hyaluronan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085029">
        <property type="term" value="P:extracellular matrix assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030213">
        <property type="term" value="P:hyaluronan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06423">
        <property type="entry name" value="CESA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22913">
        <property type="entry name" value="HYALURONAN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22913:SF12">
        <property type="entry name" value="MANNURONAN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="404"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="433"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="465"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="9">
        <location>
            <begin position="116"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIF82388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="496" mass="56123" checksum="B013A358C38D0930" modified="2014-10-29" version="1">MTLSEEKEEGEEDKKIITTSTTTTPNKSRFQTGCLQQVSQDGRIRTTRKGWALRVATLSGMSIIMAFTLYTGIMSGDALLVFSNILPLNSILSMYIAWFHYKSPITGKLEDQDVVSVIIPVYNQKEMIETVIDAIFQSTYRSIEVVAVNDGSRDGSKEILDRLAGKYSNLKVIHKKNEGKRKAVASGIFASKGEYVLLLDSDSVLDPNAVAEMVRAFKSDSKIGGAVGHVKVWNANKNLLTRVQDAWYDFAFNVGKSSESVFGSVTCCSGCLAGYRRDVIKDFVAYWAGAKMHSSDDRELTSYVLGSKWGKEKIIEIMGKPISRQLFESAASYDDAEDRVLTASALEKWKTVYVASAIVYTDVPEKFRGFLKQQERWKKGYIRTNFFVSSFFWHQRNPLMTFSFYTDFMATFSSPLIMIAVFVYAPIVHGQYYYSLSFLSSLFLKGIAIGLDYKYRDASSKNWKYYPLTIVMTNFVLSWVLFPALLRFKVNKWGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMG4</accession>
    <name>A0A075MMG4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nitrososphaera output domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699332.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMG4"/>
    <dbReference type="GeneID" id="41596158"/>
    <dbReference type="KEGG" id="nev:NTE_00243"/>
    <dbReference type="HOGENOM" id="CLU_160434_0_0_2"/>
    <dbReference type="OrthoDB" id="13402at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041226">
        <property type="entry name" value="NitrOD2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18550">
        <property type="entry name" value="NitrOD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitrososphaera output" evidence="1">
        <location>
            <begin position="5"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="103" mass="11589" checksum="A6A64D199021D7FB" modified="2014-10-29" version="1">MFQTNISVLVDAMLQNVRATLGREAYDVVMSKIIGDYFGESMDIREAIMCRPELFETAFLELLGQMGIILLSKSLAETCPESIGMQYSKRGDFARYITALYST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMM5</accession>
    <name>A0A075MMM5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699466.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMM5"/>
    <dbReference type="STRING" id="1459636.NTE_00426"/>
    <dbReference type="GeneID" id="41596305"/>
    <dbReference type="KEGG" id="nev:NTE_00426"/>
    <dbReference type="eggNOG" id="arCOG08809">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2379513_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="96" mass="10527" checksum="31563C743D8B1689" modified="2014-10-29" version="1">MTHNGVDIVDFVLYTIYPTAAFFAIGIAAKKTGLRQLYVYLIQAFVCFAFSIAYIAFIPLGGGQGIAILLAMFGALLLFMARKQKVQPAEEEQKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMN5</accession>
    <name>A0A075MMN5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00323</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMN5"/>
    <dbReference type="KEGG" id="nev:NTE_00323"/>
    <dbReference type="HOGENOM" id="CLU_2730138_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="71" mass="7904" checksum="8D26425DCFCB7A65" modified="2014-10-29" version="1">MQRSYSPSVDVRVPYSCFSTVSTIKCSLKQLKISKLALSGKAEVGEAAEGFNEAMARLIVKFCSIFRYSKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMS3</accession>
    <name>A0A075MMS3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">T4 bacteriophage base plate protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00497</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699525.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMS3"/>
    <dbReference type="STRING" id="1459636.NTE_00497"/>
    <dbReference type="GeneID" id="41596370"/>
    <dbReference type="KEGG" id="nev:NTE_00497"/>
    <dbReference type="HOGENOM" id="CLU_076891_1_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="31630" checksum="D7408C47FC544F49" modified="2014-10-29" version="1">MSQAIAAAVVSLPRGIPRPDGSWIAEATLREPVGHDEQFLLDLPAETPIYRRAIALLGRLAHFKDVPPENSEEITRQLCLGDRSALLLNIRRSMLGDRISLVLPCTNCGNNLSADLSITQLLEGGARERREVYEVQAGKYQLAIHPVTGADQDALFAKAHSRTDFQATLVRMCIRSCVPSLPATDGIPDEVYEAVSSTLEEVDPLSDTIIRVSCPECNRSFSASVPIERLFFQDTGIAARNQLEKDIHWLAFHYHWSEKDILSLPIKKRKAYIDLINATISGEMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMV9</accession>
    <name>A0A075MMV9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Precorrin-2 C20-methyltransferase</fullName>
            <ecNumber evidence="9">2.1.1.130</ecNumber>
            <ecNumber evidence="9">2.1.1.151</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NTE_00413</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.130" evidence="9"/>
    <dbReference type="EC" id="2.1.1.151" evidence="9"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699455.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMV9"/>
    <dbReference type="STRING" id="1459636.NTE_00413"/>
    <dbReference type="GeneID" id="41596293"/>
    <dbReference type="KEGG" id="nev:NTE_00413"/>
    <dbReference type="eggNOG" id="arCOG00648">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076014_2_1_2"/>
    <dbReference type="OrthoDB" id="23546at2157"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043781">
        <property type="term" value="F:cobalt-factor II C20-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030788">
        <property type="term" value="F:precorrin-2 C20-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11645">
        <property type="entry name" value="Precorrin_2_C20_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="entry name" value="Cobalt-precorrin-4 Transmethylase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="entry name" value="Methyltransferase, Cobalt-precorrin-4 Transmethylase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012382">
        <property type="entry name" value="CobI/CbiL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006364">
        <property type="entry name" value="CobI/CbiL/CobIJ_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01467">
        <property type="entry name" value="cobI_cbiL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43467">
        <property type="entry name" value="COBALT-PRECORRIN-2 C(20)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43467:SF2">
        <property type="entry name" value="COBALT-PRECORRIN-2 C(20)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036427">
        <property type="entry name" value="Precrrn-2_mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="Tetrapyrrole methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="4 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tetrapyrrole methylase" evidence="8">
        <location>
            <begin position="2"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR036427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF82495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="241" mass="26374" checksum="E7A81E4BF9043779" modified="2014-10-29" version="1">MKLYCVGCGPGDPELLTVRAVNLIRAAEVIFAPTAREGKPSIALSVVEQYVDKAAKAVSLVFPMVKDRESLKDYWIRNAGEIASAVRSGKKVVYLTVGDPALYSTWIYIHRELKKNHPDVEVEIVPGVTSIFAIANKAKISLAEGDETVAVVPACYDMERVKRTAAACDTVIFLKDGRYFDNVISTLGEAGFPDDASLAIAQDVDSEGEILEMTTLAEQRGRKGPTEKYFSIMVAKKNARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNY5</accession>
    <name>A0A075MNY5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699476.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNY5"/>
    <dbReference type="STRING" id="1459636.NTE_00440"/>
    <dbReference type="GeneID" id="41596316"/>
    <dbReference type="KEGG" id="nev:NTE_00440"/>
    <dbReference type="HOGENOM" id="CLU_1237954_0_0_2"/>
    <dbReference type="OrthoDB" id="7764at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="224" mass="25233" checksum="1006A16431460D96" modified="2014-10-29" version="1">MNNVHTTQFNVQLYFRRPALDSELLGTMFSSAQGFEAKPVTDDYGTHPMQGAMSFYREGFRIAPVQSNVLPFRILQVMSYPNVLKEPDSETLACLRFAVSKLQEHLHIDIENDIYAVRVVSHAIVDGSKQYVLSKLTTIENVPALAGRYVAHKNPMDALQIVTKTGSELSQKSWSDIRVSQFKESSYVVTIFHEAESLALALDWIAQVKQFVATMIQEMEQAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MP54</accession>
    <name>A0A075MP54_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Plastocyanin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_01241</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700100.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MP54"/>
    <dbReference type="STRING" id="1459636.NTE_01241"/>
    <dbReference type="GeneID" id="41597047"/>
    <dbReference type="KEGG" id="nev:NTE_01241"/>
    <dbReference type="eggNOG" id="arCOG02926">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1500326_0_0_2"/>
    <dbReference type="OrthoDB" id="11836at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000923">
        <property type="entry name" value="BlueCu_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052721">
        <property type="entry name" value="ET_Amicyanin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36507">
        <property type="entry name" value="BLL1555 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36507:SF1">
        <property type="entry name" value="BLL1555 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00127">
        <property type="entry name" value="Copper-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="Blue (type 1) copper" evidence="4">
        <location>
            <begin position="89"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF83311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="170" mass="18050" checksum="A619ED6E74307040" modified="2014-10-29" version="1">MARPGVIAFPVLLVLGAITGYLTYNWMIVDSVPKPGDFSDSPYYKPISAVSADQKNSTGNASGPVDESKFSNIVKISILSGASVQGSPDYDPDAPTVPKDALIKWVNNDNVPHSATSGKGFSDADYGKLFDSGFLDPGKDYSVPAEKVGAGDHVYFCQVHPFMTGTVKVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MP73</accession>
    <name>A0A075MP73_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00932</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699863.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MP73"/>
    <dbReference type="STRING" id="1459636.NTE_00932"/>
    <dbReference type="GeneID" id="41596767"/>
    <dbReference type="KEGG" id="nev:NTE_00932"/>
    <dbReference type="HOGENOM" id="CLU_2930025_0_0_2"/>
    <dbReference type="OrthoDB" id="373872at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="60" mass="7300" checksum="2B70FBD0BF79DF8A" modified="2014-10-29" version="1">MELHELFGLKGDDVWFRKGDYFYTLEQVQKIIREVLRTEPERAQRILDKFVPSDKPVYKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPQ9</accession>
    <name>A0A075MPQ9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter, substrate-binding protein, aliphatic sulfonates family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NTE_01036</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the bacterial solute-binding protein SsuA/TauA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699938.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPQ9"/>
    <dbReference type="STRING" id="1459636.NTE_01036"/>
    <dbReference type="GeneID" id="41596859"/>
    <dbReference type="KEGG" id="nev:NTE_01036"/>
    <dbReference type="eggNOG" id="arCOG01803">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028871_10_0_2"/>
    <dbReference type="OrthoDB" id="10037at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13553">
        <property type="entry name" value="PBP2_NrtA_CpmA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010067">
        <property type="entry name" value="ABC_SsuA_sub-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044527">
        <property type="entry name" value="NrtA/CpmA_ABC-bd_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01728">
        <property type="entry name" value="SsuA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30024">
        <property type="entry name" value="ALIPHATIC SULFONATES-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30024:SF47">
        <property type="entry name" value="TAURINE-BINDING PERIPLASMIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13379">
        <property type="entry name" value="NMT1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF83110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="350" mass="37759" checksum="F5D04DEDD374891D" modified="2014-10-29" version="1">MDFRLKLGIAAALVAFVIGTSVALNDQPLARYSGASGPSDVLRLGYFPNVNHAQAVIGVGNGDYQKALGNIQLETQVFTSGPSAIDGFFGNRIDCSYVGPNPAVNGYLRSEGSLKVVSGVSSGGTVFVVRNDAGIDSPADFAGKKLASPQVGNTQDVALRNYLKEHGYEVKREGGNPEIRQVKPADMLTLMAKKELDGAWVAEPWGARLVREAGARVFVNEQDLWQDGKFATSLLVCKADYIKSNPETVKRLIEAHVSETQWINSHKEEAIKSFNTAVSKILGSGFNEDDLRTSLTRMEFTYDPLEETVQKAADDAYALGLLDKKPGLSGMFDLQILNGVLQERGLATIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPR9</accession>
    <name>A0A075MPR9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4242 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700008.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPR9"/>
    <dbReference type="GeneID" id="41596939"/>
    <dbReference type="KEGG" id="nev:NTE_01125"/>
    <dbReference type="eggNOG" id="arCOG13015">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2534794_0_0_2"/>
    <dbReference type="OrthoDB" id="8127at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3090">
        <property type="entry name" value="ORF SCO4226, nickel-binding ferredoxin-like monomer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042557">
        <property type="entry name" value="SCO4226"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025336">
        <property type="entry name" value="SCO4226-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14026">
        <property type="entry name" value="SCO4226-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="92" mass="10322" checksum="690BCFC89F43AB76" modified="2014-10-29" version="1">MPTFLDVHKVPFSESNLKELCMSPTDEFGVRHVNLFYNKDSGVCFCLLEGPDMDAIEKHHSKVNIKCEWITEVTLARPSPPPDSSDKPTTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPW5</accession>
    <name>A0A075MPW5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Large ribosomal subunit protein eL21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpl21e</name>
        <name evidence="6" type="ORF">NTE_01092</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the eukaryotic ribosomal protein eL21 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699981.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPW5"/>
    <dbReference type="STRING" id="1459636.NTE_01092"/>
    <dbReference type="GeneID" id="41596908"/>
    <dbReference type="KEGG" id="nev:NTE_01092"/>
    <dbReference type="eggNOG" id="arCOG04129">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103610_1_1_2"/>
    <dbReference type="OrthoDB" id="6295at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.70">
        <property type="entry name" value="Ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00369">
        <property type="entry name" value="Ribosomal_eL21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001147">
        <property type="entry name" value="Ribosomal_eL21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022856">
        <property type="entry name" value="Ribosomal_eL21_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036948">
        <property type="entry name" value="Ribosomal_eL21_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20981">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01157">
        <property type="entry name" value="Ribosomal_L21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF83165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="99" mass="11317" checksum="645653D944DD703B" modified="2014-10-29" version="1">MPRSHGTRRKARSILTKDNVVKGISYLLHDYKVGDKVIIEVDPREHDTTPHRRFHGRIGVVKEVRKRTLKVSVMFGSKEKILQTRLNHIKPLAAPEASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQ32</accession>
    <name>A0A075MQ32_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LPXTG cell wall anchor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01211</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700075.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQ32"/>
    <dbReference type="GeneID" id="41597020"/>
    <dbReference type="KEGG" id="nev:NTE_01211"/>
    <dbReference type="HOGENOM" id="CLU_1607072_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01167">
        <property type="entry name" value="LPXTG_anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="165" mass="17262" checksum="C89168C23DC9B338" modified="2014-10-29" version="1">MTATISFSGNGFDFDINMYGFTPGELVTIVFTNVNNSNDMYSIDTYVGYNPVHVLQQHFPAEAEGNYHVTAVGSTGTKAENTLTIGYPTVQGILPNTEVPLENITNQGGETVPIFGQLENIGGAAIPAAIPTQTSQNNSIPLVLAGGALLGGLLLISGGKKKVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQ46</accession>
    <name>A0A075MQ46_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00921</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385075.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQ46"/>
    <dbReference type="GeneID" id="41596757"/>
    <dbReference type="KEGG" id="nev:NTE_00921"/>
    <dbReference type="HOGENOM" id="CLU_1067943_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="260" mass="29603" checksum="181A00AC53C4B677" modified="2014-10-29" version="1">MRIGRTVGTISLVVIVLTGATVLVLLSTWNIAESGSAFASEMTDIQTESNDEEKVPTSVNEFYPVITERWTGPNVTAVTNEMEATYTANFDVKFPREMPSSNYKLQLGLVSHEYGNHNYDDNNHVFLFYSEERITNKLTLNQFWEQGGIWVVYNKNLTMVQNNFPESKGSENYGEWNPTWFNLTDTLIAAKESGMDVYETEINGHYVVAIEAQDREFQGFTVHDPAQVEFMAGNTHVMLRGYQDTEELIEIAESMWFDPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQ78</accession>
    <name>A0A075MQ78_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_00962</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQ78"/>
    <dbReference type="STRING" id="1459636.NTE_00962"/>
    <dbReference type="KEGG" id="nev:NTE_00962"/>
    <dbReference type="eggNOG" id="arCOG10586">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_165871_0_0_2"/>
    <dbReference type="OrthoDB" id="2187at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="11"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF83037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="109" mass="11712" checksum="8D0077582D054287" modified="2014-10-29" version="1">MLYLYSRMTLPKGYGSGGRKGGSGGGGGESRDDIERMIGRRVENMKGIYILGFALCWAATAGGVYVGVTVYPWAYPLPSGLYALSVLTVIEALGFFFIMKITGEKTVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQ95</accession>
    <name>A0A075MQ95_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA/RNA-binding protein Alba</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">albA</name>
        <name evidence="7" type="ORF">NTE_01650</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds double-stranded DNA tightly but without sequence specificity. Involved in DNA compaction.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="5">Acetylated. Acetylation at Lys-21 decreases DNA-binding affinity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the histone-like Alba family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987231.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQ95"/>
    <dbReference type="STRING" id="1459636.NTE_01650"/>
    <dbReference type="GeneID" id="41597425"/>
    <dbReference type="KEGG" id="nev:NTE_01650"/>
    <dbReference type="eggNOG" id="arCOG01753">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110989_1_1_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.20">
        <property type="entry name" value="Alba-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01122">
        <property type="entry name" value="AlbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036882">
        <property type="entry name" value="Alba-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013795">
        <property type="entry name" value="DNA/RNA-bd_Alba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002775">
        <property type="entry name" value="DNA/RNA-bd_Alba-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01918">
        <property type="entry name" value="Alba"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028732">
        <property type="entry name" value="Alba"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82704">
        <property type="entry name" value="AlbA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="2 5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="3 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA/RNA-binding protein Alba-like" evidence="6">
        <location>
            <begin position="15"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="5">
        <location>
            <position position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF83711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="102" mass="11104" checksum="89C0AABCAA3DDEDB" modified="2014-10-29" version="1">MSTSTNTTRPPKASNEIFIGKKPLMTYVTATLVQLANEPTVVIKARGKSITRAVDVAQIIVKRMDTIGYKIGPIKLGSEQVTSEDGKMRNVSTIDVPISRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQE4</accession>
    <name>A0A075MQE4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Probable thymidylate kinase</fullName>
            <ecNumber evidence="7">2.7.4.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">dTMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tmk</name>
        <name evidence="9" type="ORF">NTE_01028</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>dTMP + ATP = dTDP + ADP</text>
            <dbReference type="Rhea" id="RHEA:13517"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58369"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the thymidylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.9" evidence="7"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699932.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQE4"/>
    <dbReference type="STRING" id="1459636.NTE_01028"/>
    <dbReference type="GeneID" id="41596851"/>
    <dbReference type="KEGG" id="nev:NTE_01028"/>
    <dbReference type="eggNOG" id="arCOG01891">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049131_3_2_2"/>
    <dbReference type="OrthoDB" id="43083at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004798">
        <property type="term" value="F:dTMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006233">
        <property type="term" value="P:dTDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006227">
        <property type="term" value="P:dUDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01672">
        <property type="entry name" value="TMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00165">
        <property type="entry name" value="Thymidylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039430">
        <property type="entry name" value="Thymidylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018094">
        <property type="entry name" value="Thymidylate_kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00041">
        <property type="entry name" value="DTMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10344">
        <property type="entry name" value="THYMIDYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10344:SF1">
        <property type="entry name" value="THYMIDYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02223">
        <property type="entry name" value="Thymidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate kinase-like" evidence="8">
        <location>
            <begin position="11"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF83102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="198" mass="22415" checksum="B0BB1DA7180540E5" modified="2014-10-29" version="1">MAVAKGKIIVIEGTDKAGKTTQSRMLQEAIKALGKICVVIDFPDYTTPIGMEIRAFLDGKRDYPAEVKHLLFSANRWEKKKEIESMVENGTIIIMNRYWQSNLVYGISNGMDAGWLQKLDKGLPKEDMVLILLVNPSVSKNRAEVLDAFEGDARLAEAAYKNYQKLARQFKWKVLDGSKSKEQVHQEILKTVRKALKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQF1</accession>
    <name>A0A075MQF1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_01370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700209.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQF1"/>
    <dbReference type="STRING" id="1459636.NTE_01370"/>
    <dbReference type="GeneID" id="41597167"/>
    <dbReference type="KEGG" id="nev:NTE_01370"/>
    <dbReference type="HOGENOM" id="CLU_2662140_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="42"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF83438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="75" mass="9237" checksum="A394F7E711AC6908" modified="2014-10-29" version="1">MIDKMEELNHKHVEDEMAKGRNPDESIVMQVNEMYRLLLRGWLRSEKELLEVEERIRELEKKSRKQNTTRKKRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQH7</accession>
    <name>A0A075MQH7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Small nuclear ribonucleoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_01725</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_075053799.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQH7"/>
    <dbReference type="STRING" id="1459636.NTE_01725"/>
    <dbReference type="GeneID" id="41597494"/>
    <dbReference type="KEGG" id="nev:NTE_01725"/>
    <dbReference type="eggNOG" id="arCOG00998">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076902_11_0_2"/>
    <dbReference type="OrthoDB" id="371816at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01726">
        <property type="entry name" value="LSm6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016487">
        <property type="entry name" value="Lsm6/sSmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021:SF0">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F SNRNP-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006609">
        <property type="entry name" value="snRNP_SmF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Sm" evidence="2">
        <location>
            <begin position="11"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF83786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="83" mass="9472" checksum="26FC270DC7120ABD" modified="2014-10-29" version="1">MSSPSSQQPKRPLSILQRSLNRKVAVRLKSEIEYKGRMNNVDSYMNLILTDAEEFNGADVMANYGKVVIRGNNVLFIRLEKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQK1</accession>
    <name>A0A075MQK1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699967.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQK1"/>
    <dbReference type="STRING" id="1459636.NTE_01074"/>
    <dbReference type="GeneID" id="41596892"/>
    <dbReference type="KEGG" id="nev:NTE_01074"/>
    <dbReference type="eggNOG" id="arCOG10529">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1607071_0_0_2"/>
    <dbReference type="OrthoDB" id="10920at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="165" mass="18620" checksum="28B6DE1F427C8BBF" modified="2014-10-29" version="1">MSGKEEKQQGFFKRYREAIKFNRNIVIAGLGAFFTGALVAQLYSSFDKSGNNLANSAFTLASEYAVYIPAFAFLYYWDNRYKYVDPSTGRRDSKKLRADVKKLLATFSVSEVAFSLTKVGVQFQLLQSSNDAYISAMAASIVAWAVFFVLVNYMARLVRLFRNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQM9</accession>
    <name>A0A075MQM9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_01780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700539.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQM9"/>
    <dbReference type="STRING" id="1459636.NTE_01780"/>
    <dbReference type="GeneID" id="41597546"/>
    <dbReference type="KEGG" id="nev:NTE_01780"/>
    <dbReference type="HOGENOM" id="CLU_270823_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="917"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1117"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1182"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="130"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="696"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="917"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1120"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1187"/>
            <end position="1198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF83841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="1206" mass="128002" checksum="A572309C28E2B2D6" modified="2014-10-29" version="1">MSSPMEIAYKKYQELNAQKQAQFLQTGKTESITAADIAAAPSPAPTNTNSNGLSDEAQRTLATQTFLEAQRRAQDQALYSGQTQNLSDFLPEARQAVEDSYTVAITPGFGKLGGGSRYEEGPMRTMSIPIHDKAAEAKRLEKNYAAYQSQNLAAQRQSLAQSGQNGASQRVYVSRLALGDNILQFVREQEKGGKVKYAGQVEVSPTGDITPLFVDVAESKKNYADFMSVQRQNGAIRAANEKAQADYDAWISDMQAKGFGGLVETKDSSGKTTAKFTTFTSGGKTVGVRDDGTFEIPDPYKDAKLNLDAAEQVWRFGVEGFGAAGAGLVSLGGNLISKAEDALGFKAQAERTRNNSAAASQAIKSATDLGAFSTLTESIGRTFGSDTFYAESSKAAQDKKIIDAQNIPVGSIVGLGAAYGVKELEKSGMKQSVESATGLSFGSGDEAIAQQYKALQERPVEFIGGTIADILTFGNPVKIVKGVSKVASGLKLTRSVEKEAQAAAKRAGVEGDVSVRPIEQRKIPATGEVVDVPLQPTRFANVAVASRNVKIPLVGGKKIDLGIMQNETPIASINIPESISVKKLTINPTREVVTQEGTPIGIISPRSNTAVIQNPSPLPLAAKADLVGQDVKSVAAVQDTTQWIKNQAKAPSAEEIKLKATDPYYNSPKIQEMIEGYALKNDFTLNSKSAKLSKKLEPLYSKADNLRMQKEQLQSELSDINDHIAVASNQKSENMFAVDSSTDAATSKEVADLTSQKSDLLQKISGIDEKLTGIESEISSTTTAFGIKRADALGALQHASEFFYKVGGKGRINPAKGGAPADVMFPKVQNAPKSSNLIASSTTDVYNLEQNPALPSARLSRLAGYDLARDSEGLDPLSGNYFITKGGKAIKLMKEQVATDVEFDLNKVSKFVKEDTKRSKAVSDEARTKKPSTPFTFNVEPGRTPSAELPKTNGGKLIEVSSAKEAPSFASVKNTIFEAESSARVKGLGLGGNAGAYTNIGAIGLGGLTGAERVSKKKTSQNVSESTEFLRYPGESLSHKTKQDTRTDSLLNLGSLSSTANPFNLKPQKGGLDVANPFSHGTGSKTGGKADIIMTPRDITSTGSRLDQGTITDLNFRLDTTTGRPPRSPPTSRKVPPIAIPTFMPGGVAASQGSKGGVSSFKQRGVKNILFGAGAFDIQEGGQKQVKAGKSKGKKKSKGLWGGGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQV6</accession>
    <name>A0A075MQV6_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cell division protein SepF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01416</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700241.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQV6"/>
    <dbReference type="STRING" id="1459636.NTE_01416"/>
    <dbReference type="GeneID" id="41597210"/>
    <dbReference type="KEGG" id="nev:NTE_01416"/>
    <dbReference type="eggNOG" id="arCOG02263">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2406201_0_0_2"/>
    <dbReference type="OrthoDB" id="6148at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.150">
        <property type="entry name" value="SepF-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007561">
        <property type="entry name" value="Cell_div_SepF/SepF-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038594">
        <property type="entry name" value="SepF-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04472">
        <property type="entry name" value="SepF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="97" mass="10949" checksum="8858CF197D07DB01" modified="2014-10-29" version="1">MTDRPTTTQKAPVYLKALTLRDITDAQGVKEDIKKHMIVILRVTPLAQKDVEELRKVVEELYSYAQSVGGDIARLGEERIVITPPGVKIWRGAYDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MR29</accession>
    <name>A0A075MR29_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NTE_01492</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700304.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MR29"/>
    <dbReference type="STRING" id="1459636.NTE_01492"/>
    <dbReference type="GeneID" id="41597281"/>
    <dbReference type="KEGG" id="nev:NTE_01492"/>
    <dbReference type="eggNOG" id="arCOG02358">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015921_0_0_2"/>
    <dbReference type="OrthoDB" id="342253at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050736">
        <property type="entry name" value="Sensor_HK_Regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43711:SF1">
        <property type="entry name" value="HISTIDINE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43711">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="505"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF83555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="749" mass="84858" checksum="7209906C62D6C08E" modified="2014-10-29" version="1">MMSQQLSDESSTERHEAGTTRVLYGAEKAVGMGIKFMSNVKKRMDISFDSRGASIVVEVPAYWNGYLDIKSRGGQIRVVTEITKANLHYCKRLAKIAQVRHLNGMTGGIAVNETEYMATTTLEEAKPLTQVIYSNVEEVVRQGHCLFEILWENSIPAQDRFREIEEGVEPERTRVLYGADRILNQVVECFSSIKYTFDNCTDSAGPSIFLGNEPLKTEYSKLKDRGVKLRFITEITRDNVSYCKQLMRVADVRHLNKVRGNFGIVDKRLYAASGVEHQGKIPSRLVTSTIRAFVEQQQYFFETLWKKAMPAEQKIREIEEGVKPEYIVTINDPDKVQKIAFDLANSAKSEILVMFSTANAFHRQERAGGVQLLMDAARKRNVKVRILTPFDDRIGEVSRNVREELVMRRHDLEKTAAGDIDIKYTEPTLQTKISLLIVDSRFSLAVELEDDAKETTSEAIGLATLSNSKATVSSYVSMFESMWRQNELLEKLKAHSKMQQEFINIAAHELRSPIQPIMGLSELLYFKATNDQQRELADIIRRNAERLHRLAENILDVTRIESQSLRLDKEQFSLKELLEDTIRDYKKSPDYNNNNNNNSIQLIYPSEKIDDDIFVQADKERIKQVISNLLSNAFGFTRGEGTVLVTVEREKRDDGSGQFVIVSVRDSGSGIAPEILPIMFEKFTTKSEKGTGLGLFISKGIIEAHGGRIWGKNNDDDDRKKGATFTFTLPTTIIVTDQQQDPVPGCKQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MR39</accession>
    <name>A0A075MR39_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01502</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700312.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MR39"/>
    <dbReference type="GeneID" id="41597290"/>
    <dbReference type="KEGG" id="nev:NTE_01502"/>
    <dbReference type="HOGENOM" id="CLU_851570_0_0_2"/>
    <dbReference type="OrthoDB" id="11671at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="274" mass="29259" checksum="AC0DC41C35BC6DA1" modified="2014-10-29" version="1">MKTILMALAIFASVILLGSAIALGPVNRAYAHTFQGSENVEFLTMVQQIKVETSLAGNNTSDKEVANHHMEHAAEALTNSTLKEIAEKNKRIATDLPSSIEQLKTAIDSGASADEVKQDVQAVSDLLDEAVQIRIEKSQVDNSTIQAAVVANLVNEALEHYGEAVGFEGNMTDMSAMQSENSSMQGNTTTTSTVVSVPNYQSSLAFAEKAQELYQQIKSKALSGTDNAVTGLDGAFPSFVNAIKGKASPMDIMEIAHTKIHPNLITAYNLQVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MR68</accession>
    <name>A0A075MR68_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nitroreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NTE_01998</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nitroreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700705.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MR68"/>
    <dbReference type="STRING" id="1459636.NTE_01998"/>
    <dbReference type="GeneID" id="41597745"/>
    <dbReference type="KEGG" id="nev:NTE_01998"/>
    <dbReference type="eggNOG" id="arCOG00288">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070764_7_1_2"/>
    <dbReference type="OrthoDB" id="287850at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="entry name" value="NADH Oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43673">
        <property type="entry name" value="NAD(P)H NITROREDUCTASE YDGI-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43673:SF2">
        <property type="entry name" value="NITROREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="FMN-dependent nitroreductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="6">
        <location>
            <begin position="12"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="Nitroreductase" evidence="6">
        <location>
            <begin position="70"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF84056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="168" mass="18387" checksum="A045813AB3E03EB0" modified="2014-10-29" version="1">MDIFDGIATKLDVRQYSPQNVSSEIKQSVLEAARLTGTGLNTQHWRFILVEGKDRLATLAEDSTSGGWVAGANFAVIVLTNPDYKFHMIDAGRVLQNMQLAAWNHGVASGIFTGVKEEKLRKDFAIPKELNITLIAGFGYPAKKLAGKKSRVPLNELVYYGKYGNAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRD8</accession>
    <name>A0A075MRD8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01314</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700164.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRD8"/>
    <dbReference type="STRING" id="1459636.NTE_01314"/>
    <dbReference type="GeneID" id="41597116"/>
    <dbReference type="KEGG" id="nev:NTE_01314"/>
    <dbReference type="HOGENOM" id="CLU_158398_0_0_2"/>
    <dbReference type="OrthoDB" id="7164at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="131" mass="14896" checksum="766CAC987F6B873C" modified="2014-10-29" version="1">MMKSGFYDELSEKTYNEIPRIPASNRVMLHVSQFSVGQSYVTAKVENRHGNTVNINIEGGRLGVDLQETLFRLGDRLPKYAYIVTTVNETGKILARKVPVLGVKDWLLIYEDDLFLLAVKDAYDEIEIMVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRF0</accession>
    <name>A0A075MRF0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01324</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRF0"/>
    <dbReference type="KEGG" id="nev:NTE_01324"/>
    <dbReference type="HOGENOM" id="CLU_3227631_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="43" mass="5255" checksum="C914544C876E63C9" modified="2014-10-29" version="1">MMVLLLLQFYAFWNSLYEESCRTVLDFFGYEKENLSSEFIDYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRL3</accession>
    <name>A0A075MRL3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative phosphohydrolase</fullName>
            <ecNumber evidence="5">3.1.3.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_01390</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="5"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385179.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRL3"/>
    <dbReference type="STRING" id="1459636.NTE_01390"/>
    <dbReference type="GeneID" id="41597186"/>
    <dbReference type="KEGG" id="nev:NTE_01390"/>
    <dbReference type="eggNOG" id="arCOG01143">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004962_0_10_2"/>
    <dbReference type="OrthoDB" id="303721at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00144">
        <property type="entry name" value="MPP_PPP_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051134">
        <property type="entry name" value="PPP_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668:SF5">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="4">
        <location>
            <begin position="121"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF83457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="311" mass="34230" checksum="A9E0B5CBC3C242DB" modified="2014-10-29" version="1">MSQIVRLSATAGPSEFSQVLEQGISALKEEQKRGAIAGGTVTGGLVEIKDYDQLVVLSDLHGDSQALFQILDAVNYEKFLSGPENKMVFLGDYVDRGSDSIGVLYAICYLKHAHPDSVILMRGNHEAPSEFPFPSHDLPYDIEDRFGAGAKAIYGRILALFGLLTLATVVQGRLLLVHGGLPTDALGDWRQAIATAQKSHLKNRVMEELLWNDPRPLGEEWEPSWRGIGRHFGSAVTKRWLADTNTKVVVRGHEPCHGYRIDHHSMMLTLFSCRQAYPGFGAAYISAGKNDLDSVNDADDLAKFVKKLPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRW4</accession>
    <name>A0A075MRW4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_01774</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700535.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRW4"/>
    <dbReference type="STRING" id="1459636.NTE_01774"/>
    <dbReference type="GeneID" id="41597542"/>
    <dbReference type="KEGG" id="nev:NTE_01774"/>
    <dbReference type="eggNOG" id="arCOG06914">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG08578">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_358883_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04859">
        <property type="entry name" value="Prim_Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015330">
        <property type="entry name" value="DNA_primase/pol_bifunc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045455">
        <property type="entry name" value="NrS-1_pol-like_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051620">
        <property type="entry name" value="ORF904-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014818">
        <property type="entry name" value="Phage/plasmid_primase_P4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35372">
        <property type="entry name" value="ATP BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35372:SF2">
        <property type="entry name" value="SF3 HELICASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08706">
        <property type="entry name" value="D5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19263">
        <property type="entry name" value="DUF5906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09250">
        <property type="entry name" value="Prim-Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00885">
        <property type="entry name" value="D5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00943">
        <property type="entry name" value="Prim-Pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56747">
        <property type="entry name" value="Prim-pol domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA primase/polymerase bifunctional N-terminal" evidence="3">
        <location>
            <begin position="9"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Bacteriophage/plasmid primase P4 C-terminal" evidence="2">
        <location>
            <begin position="327"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF83835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="780" mass="88692" checksum="FF6853BC5204E284" modified="2014-10-29" version="1">MSSNIAEEAARYVSMGINLVPLAARSKIPEAGIDLDKYFNELFPADRLQEMIAKGCNIAVICGKISLVIVIDIDGEPATQMWADTISKVPTLKEKLEAKDTQLVKTSGGYHIYLRFNLSEFEDGIGRIKLWKGTGAHEEIVIRGNGSYVVGAGSIHPDTGKVYERRGQTIPTITKAEYEQLLNAFNIASKSSTASRQQTAGVTKVSPLHIAALADCAKSIYSEGSRNDVGLRLIGDLRHKGFPEDAVKEFVIKLHGDDRDKIVKAVDATFRKDIAQINSRAELERELLANHDYKTVQRFFKQWDKLIKEALAASRKVQDWEDSEERIVALTEDVKSKFIVKATGQDRRLCIYNDGVYEEKDAEQAIERYLEEISPGINNHDVNEVLNKLRRREYVNEVEFDNNPYMINFRNVWYNWLEDKTYPHSPDLLSMHQLPYPYPEVKQVPKNFYRFMAGVRYPEDGNREIKGIHYPHEVKTAMDWMAYTFMKENKFELVCFKIGYGKNGKTTEDSLLKALHGGKSEKGSFVGGSVTGFSLRQIIENRFATYRMKGKALNIDAETDGRAIDMTELKRLASRDTIHEVEGKGTNFESVILNTKFQMNFNKDPIIINQSDGDIRRLLMLSYPHQFEGKSDDTDILQKLLTEEELSNIFAWVIAPALRRLNTAKSLYMKYNKIEDRRTRYELVTNPMKAATDAIFLSSSTSEDYVTKAEAYDAYKKFCAKNNLAVQSKKLFGTYLHKEMMVQDGYRGPKGKQDEVWLGLRVNPAYTVDLKQAQFTPAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MS42</accession>
    <name>A0A075MS42_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphatidylglycerophosphate synthase</fullName>
            <ecNumber evidence="4">2.7.8.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_01924</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.5" evidence="4"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700646.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MS42"/>
    <dbReference type="STRING" id="1459636.NTE_01924"/>
    <dbReference type="GeneID" id="41597672"/>
    <dbReference type="KEGG" id="nev:NTE_01924"/>
    <dbReference type="eggNOG" id="arCOG00670">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080384_1_2_2"/>
    <dbReference type="OrthoDB" id="9904at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF83983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="203" mass="21045" checksum="2C99B5E1BDCBD9BA" modified="2014-10-29" version="1">MLNRLRDSLQPTMEKLGSGFASTGLSANFWTGVGLALALAAGVAYASASFGFGIDKYPAAVIGGVLLLVSGFFDMIDGAVARATKQASKKGAFLDSSFDKIAEVVIFIGIAVGGLANPVWCMVGLGMSLLVSYTRARAESLGVELKGIGIGERAERMLILAIIGFIPYDGMANDGAPDWAVIIVSIVAGITLVQRIVATAKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MS82</accession>
    <name>A0A075MS82_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01916</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700642.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MS82"/>
    <dbReference type="STRING" id="1459636.NTE_01916"/>
    <dbReference type="GeneID" id="41597665"/>
    <dbReference type="KEGG" id="nev:NTE_01916"/>
    <dbReference type="eggNOG" id="arCOG04056">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2392996_0_0_2"/>
    <dbReference type="OrthoDB" id="8193at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="96" mass="10810" checksum="55AE159C99F96BF9" modified="2014-10-29" version="1">MSDIETGLGSIGKIKIIRALAQEGRMATIYLLHKKTGLKREDIKNNLDDLVKIGWVKQAKYASVMYGLGESENVIKLVQFFRDVGYVDGGRHHHQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MS86</accession>
    <name>A0A075MS86_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Archaeal histone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NTE_02374</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the archaeal histone HMF family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MS86"/>
    <dbReference type="STRING" id="1459636.NTE_02374"/>
    <dbReference type="KEGG" id="nev:NTE_02374"/>
    <dbReference type="eggNOG" id="arCOG02144">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_192667_0_0_2"/>
    <dbReference type="OrthoDB" id="7514at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22909">
        <property type="entry name" value="HFD_archaea_histone-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050947">
        <property type="entry name" value="Archaeal_histone_HMF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050004">
        <property type="entry name" value="HmfB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF043032">
        <property type="entry name" value="archaea_histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47828">
        <property type="entry name" value="ARCHAEAL HISTONE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47828:SF1">
        <property type="entry name" value="ARCHAEAL HISTONE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="7">
        <location>
            <begin position="3"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF84426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="63" mass="7125" checksum="DD38CB5E2D9F4087" modified="2014-10-29" version="1">MYRIMKKSGAERVSDDAADELRKVLEEAAERIAKQAAEFSIHAGRKTIKPEDIRLASKNVIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MS87</accession>
    <name>A0A075MS87_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD kinase</fullName>
            <ecNumber evidence="5">2.7.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP-dependent NAD kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nadK</name>
        <name evidence="6" type="ORF">NTE_01921</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>NAD(+) + ATP = ADP + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18629"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NAD kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.23" evidence="5"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700644.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MS87"/>
    <dbReference type="STRING" id="1459636.NTE_01921"/>
    <dbReference type="GeneID" id="41597669"/>
    <dbReference type="KEGG" id="nev:NTE_01921"/>
    <dbReference type="eggNOG" id="arCOG00394">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG01348">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008831_0_2_2"/>
    <dbReference type="OrthoDB" id="350804at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275:SF0">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20143">
        <property type="entry name" value="NAD_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5 6" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="124"/>
            <end position="125"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="165"/>
            <end position="170"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF83980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="333" mass="36708" checksum="894C5C04BAC40DFA" modified="2014-10-29" version="1">MKVALWGVDSRDGALLTKMKKTLDSLGIKSQIMKDGDYGTASEVDMVLVAGGDRGILEYFHKVTAASAPVLGIYETDSTGFLAQLDVRDLEKATSRLKRGEYKVDEVFRLAVRVDGKEVDPVLNDVAVFPSKSATLMEHVLKIDGRDIWHDNSDGVIISTPTGSTAYTMSAGGPMVIQKSQVFVVVSVNSLDNTRRPLVVPNDASIEIADITSRYHCEVVLDGGRRVRVKNTLECTRHAFPARLVRTADDSAASLMAKKVRLAEDMLKMPPSAKLILKTLEYEGALSQKDLATRTMLPERTIRLSLSHLIDGGYVKKKTSLRDARQRIYELKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSA3</accession>
    <name>A0A075MSA3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02399</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701023.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSA3"/>
    <dbReference type="GeneID" id="41598110"/>
    <dbReference type="KEGG" id="nev:NTE_02399"/>
    <dbReference type="HOGENOM" id="CLU_2766243_0_0_2"/>
    <dbReference type="OrthoDB" id="373372at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="69" mass="7825" checksum="6D17B7A93C218DFA" modified="2014-10-29" version="1">MQEVVDSVRRLVSECRNDNDIDRQVSILIRANAMLPPSMQLKIPSLITADYIRKALSDIEEQIEAIPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSA6</accession>
    <name>A0A075MSA6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative DHD superfamily phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_02404</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSA6"/>
    <dbReference type="STRING" id="1459636.NTE_02404"/>
    <dbReference type="KEGG" id="nev:NTE_02404"/>
    <dbReference type="eggNOG" id="arCOG00424">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071985_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052968">
        <property type="entry name" value="Nucleotide_metab_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42146">
        <property type="entry name" value="3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42146:SF1">
        <property type="entry name" value="OLIGORIBONUCLEASE NRNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="DHH phosphoesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDH" evidence="1">
        <location>
            <begin position="2"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="DHHA1" evidence="2">
        <location>
            <begin position="237"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF84456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="323" mass="34988" checksum="4DFB3199256E9B3D" modified="2014-10-29" version="1">MSHKEDVDGLASAALAKAAFDAQTVILSDYPALIPKLEKLATSEKKIDSLFICDLGLSKKNEQRFVELLAKITGKGTKVTYVDHHDISKETVAGLKKAKVTLVHTVKECTSVQVYRKYKKKLPESATFLAAMGALTDYMEKKPAAAKLVPRYDRQFLMLEATSLSYMISASQKDEDFLVRIVDTLSKGRYPHDVKGGFELAERYAKKVANAVESIRSGIVKLDNLAHAPSTVELSSSMVVNFVLGSSGKPAAMVYKLKEDIGSYVVSIRGSKSCKVHLGRLVNDIASGLGGSGGGHDKACGAVIPKDRLNEFIKTLDSKMVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSB1</accession>
    <name>A0A075MSB1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acyl-CoA synthetase (NDP forming)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NTE_01631</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700416.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSB1"/>
    <dbReference type="STRING" id="1459636.NTE_01631"/>
    <dbReference type="GeneID" id="41597407"/>
    <dbReference type="KEGG" id="nev:NTE_01631"/>
    <dbReference type="eggNOG" id="arCOG01338">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG01340">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007415_2_2_2"/>
    <dbReference type="OrthoDB" id="18103at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043758">
        <property type="term" value="F:acetate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053579">
        <property type="entry name" value="3HP/4HB_CoA_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051538">
        <property type="entry name" value="Acyl-CoA_Synth/Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043938">
        <property type="entry name" value="Ligase_CoA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032875">
        <property type="entry name" value="Succ_CoA_lig_flav_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF045492">
        <property type="entry name" value="HydPropCoALig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43334:SF1">
        <property type="entry name" value="3-HYDROXYPROPIONATE--COA LIGASE [ADP-FORMING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43334">
        <property type="entry name" value="ACETATE--COA LIGASE [ADP-FORMING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13549">
        <property type="entry name" value="ATP-grasp_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19045">
        <property type="entry name" value="Ligase_CoA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13607">
        <property type="entry name" value="Succ_CoA_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="5">
        <location>
            <begin position="27"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF83692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="707" mass="76862" checksum="594C1B159E0EBE5D" modified="2014-10-29" version="1">MANQKVQKIFDDVFATKEKVITEELAKQVLTEYGVKVPPYALVTSEADAAAKAKAMGFPLVAKIVSPEILHKTDVKGVKVGLQNEAQVKDAFSDMHGRLSEQYNTVKGVLLEKMVPQGAELIVGLQNDPQFGPIIMVGIGGIYTEVFKDVAFRVLPITKQDALDMINDLKGKKILEGFRGAAPVDKDMIASALVSIGNLGTEMAPYYESIDFNPVIFYEKDYYVVDAKIILRQAVDANAVSKVQPDSSYMDLFFNAKSIALIGASPEAGKVGNSVLESMVKHDYKGKVFPVNAKGYPEIMGIKAYKSLDDIQENVELVVVTVDLKFVPDLMRSAAKKNIHNFVVISGGGKELGGERAAIEAEVKKLSQELKIRIIGPNCIGMFNGANRLDCAFQGHARMLRPKNGNVAFLSQSGTVGIAFMESSDVFGMSKMISYGNRSDVDEADMIWYLSEDPNTKVIGLYVEGLGDGRKFMNTAKKVITERKKPIVVFKNGRSARGAKQAASHTGSLGGSYGVVKGALDQAGIISVDGYEELTAALKALNWQPVPKGSRVAMVTNGAGPIIAAIDNFERLGLQVAELSEQTKKAFKEHYPPTYVIGNPCDITGSANADDYRFAIQAFMDDPNVDIIMPWFVFQDDPLEETIVDVLASFQKQKKKPILIGAMGGPFTKNISKRIEDANVPVYHSVIEWVTAAGAVAKWAKVSDATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSG2</accession>
    <name>A0A075MSG2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative membrane-associated Zn-dependent protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NTE_02003</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700709.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSG2"/>
    <dbReference type="STRING" id="1459636.NTE_02003"/>
    <dbReference type="GeneID" id="41597750"/>
    <dbReference type="KEGG" id="nev:NTE_02003"/>
    <dbReference type="eggNOG" id="arCOG04064">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042134_1_0_2"/>
    <dbReference type="OrthoDB" id="15212at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031293">
        <property type="term" value="P:membrane protein intracellular domain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05709">
        <property type="entry name" value="S2P-M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001193">
        <property type="entry name" value="MBTPS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13325:SF3">
        <property type="entry name" value="MEMBRANE-BOUND TRANSCRIPTION FACTOR SITE-2 PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13325">
        <property type="entry name" value="PROTEASE M50 MEMBRANE-BOUND TRANSCRIPTION FACTOR SITE 2 PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01000">
        <property type="entry name" value="SREBPS2PTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M50" evidence="6">
        <location>
            <begin position="99"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF84060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="414" mass="44009" checksum="135AE749983F41DF" modified="2014-10-29" version="1">MEQQRKVRAEVKLPLILIHTPFGLDFFDKVARAPGAKAWAKVNTYLMPAITVLAIFLIIGSLAVLFANSEARTSIRGVGPTANLLIPGLNPYLPITYGWAALVITIIIHEAGHGIIARVYNIRVDSTGLVLFLGIPIGAFVNIERDELAKATFKQKSAVLTAGPLNNMILAGASLLALFLVMTTLSPLPPAPGEPQFGVAVVSVNPDSLAQSIGLPQGAVIQEVAGQQVRKIEDLGPMLRANLGQTIDITWVERSTGDGNIASFATVTKSVTLPDAVEPGKGTLGIGVATLDTTGAVLERYKGAFGSNPLAILLPPTIQEGVVPYSDLMTPKYESTIGPVWSPLANMLFWLWFVNFNVGIFNALPIGPLDGGQLYSALIEKKIKSQVMAKNAATMLTILMAVIVAAAILLPYVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSJ3</accession>
    <name>A0A075MSJ3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MEDS: MEthanogen/methylotroph, DcmR Sensory domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSJ3"/>
    <dbReference type="STRING" id="1459636.NTE_02072"/>
    <dbReference type="KEGG" id="nev:NTE_02072"/>
    <dbReference type="HOGENOM" id="CLU_1307773_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025847">
        <property type="entry name" value="MEDS_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14417">
        <property type="entry name" value="MEDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MEDS" evidence="1">
        <location>
            <begin position="30"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="210" mass="24417" checksum="8FFEE2D804635EA7" modified="2014-10-29" version="1">MFLLGERWGFMSAKNYRPIKFLDRMEGNNHIVLLYDNPKYADVVIARYLLNGLQKGESCIFFSPDEPKTIEERLSAKGIDVDSYKQANSLRIYRTERSDAGKLDMLSTLRRIREESTKGMRPPYRFVGRTITDTETKEGMTLGLAVEKSGHEHFEEFDCSQMCYYDISGIEQSRRDEWIRGLLKNHHHVIYASEPDKAVAFETMLLEDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSM7</accession>
    <name>A0A075MSM7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02084</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385356.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSM7"/>
    <dbReference type="STRING" id="1459636.NTE_02084"/>
    <dbReference type="GeneID" id="43502637"/>
    <dbReference type="KEGG" id="nev:NTE_02084"/>
    <dbReference type="HOGENOM" id="CLU_113174_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="144" mass="16244" checksum="16C6DCA291E16B82" modified="2014-10-29" version="1">MSSLTAKKTAFLLALLAVGFAVASSAVTMPTAAFASGYNNSYKWTSYDDDDDDNCDDDDDDKNDYHWSSYNNDDDDDNCGCDDDDDDDDDDDNGKDYWSSSNSNGNWADYKNISYNDDDDDDDNCDDDDDDDDDNGHDHYWKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSM8</accession>
    <name>A0A075MSM8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02534</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701127.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSM8"/>
    <dbReference type="STRING" id="1459636.NTE_02534"/>
    <dbReference type="GeneID" id="41598233"/>
    <dbReference type="KEGG" id="nev:NTE_02534"/>
    <dbReference type="HOGENOM" id="CLU_1507319_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="184" mass="19126" checksum="82167903A7C00CEB" modified="2014-10-29" version="1">MTSLTNLGSNDVVQLALGAVGGFAVNQIANSQPVLNSPIIPLTGMVSLTKADALTGGLGLAAAGTGYVLKQKTFVNLGAGAVVGTVISKMASAAGFNLQNHVTSAVSQARAIWDRTFTPSQAYASAPQGNLRKMTPRDIRAQNDGRANSFLYSFTPTSNGGSYRANELSRSVNSKISYADFSYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSM9</accession>
    <name>A0A075MSM9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00272</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSM9"/>
    <dbReference type="STRING" id="1459636.NTE_00272"/>
    <dbReference type="KEGG" id="nev:NTE_00272"/>
    <dbReference type="HOGENOM" id="CLU_2406202_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="92" mass="10116" checksum="95F3C78CD379555A" modified="2014-10-29" version="1">MPLIHLRCLEEKKVVGLSDEDCALQRENDPLALQDACAFMLYRPCDHEIVLSDTAHALAVVGGARNIVLGDDHLISLGSFREIKILTVASIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSQ6</accession>
    <name>A0A075MSQ6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02128</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700805.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSQ6"/>
    <dbReference type="STRING" id="1459636.NTE_02128"/>
    <dbReference type="GeneID" id="41597856"/>
    <dbReference type="KEGG" id="nev:NTE_02128"/>
    <dbReference type="HOGENOM" id="CLU_1472032_0_0_2"/>
    <dbReference type="OrthoDB" id="11131at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="183" mass="19392" checksum="0CBBDC09796AEFEC" modified="2014-10-29" version="1">MMTILAAIVAHISAAKCRKFLAGDGITSPDFVLLPLLGVIEEGVSVDARAARKSVPALGETFSIAKNLDEYQSKICALAPSLADKNPVKVQLQKYRIGIIAAFARLGPLVMAGDVAEWNRQARLLLEEASNAYVASAAPGQRKYYAASMAEVFSFFGVPEGQVDAALAQMYGSSAASLHDDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSQ8</accession>
    <name>A0A075MSQ8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acetyltransferase (GNAT) family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_02567</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701152.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSQ8"/>
    <dbReference type="GeneID" id="41598263"/>
    <dbReference type="KEGG" id="nev:NTE_02567"/>
    <dbReference type="eggNOG" id="arCOG04971">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1544139_0_0_2"/>
    <dbReference type="OrthoDB" id="12207at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36449:SF1">
        <property type="entry name" value="ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36449">
        <property type="entry name" value="ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF84611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="173" mass="20094" checksum="8D0961EA8EE4511B" modified="2014-10-29" version="1">MKLDPIKFNVRLWQESDDLSHLNCKEPDGSDPLGVQEFLEKKAVQYHKSRLCSLFVTTYEQKPVGFFALCMSAIESPRLAADEKVNGYTPRSYPAMLLAQMGVNLPFRNQGIGIEIRDFCLGIAVDIGERVACRYVILQTNEHLSNYYRKYWEFIKQENPPHRGKVWMYRRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSR2</accession>
    <name>A0A075MSR2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative xylanase/chitin deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_00307</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699382.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSR2"/>
    <dbReference type="STRING" id="1459636.NTE_00307"/>
    <dbReference type="GeneID" id="41596211"/>
    <dbReference type="KEGG" id="nev:NTE_00307"/>
    <dbReference type="eggNOG" id="arCOG02876">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1127116_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0858">Xylan degradation</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="2">
        <location>
            <begin position="32"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF82389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="268" mass="29595" checksum="06C95B704EDE72F2" modified="2014-10-29" version="1">MKAAHVGMITTAIVVVLSVVTIIPAFTQQNAKPEVPVMLVFDINDDNAQNLPAWCTDLSASLEGHNVRATVFISGKLAEQYPQCVAIFSSSSSADKETMMIDVGSKTYSYANLILMQDYTQALEEVRKGKDAVDRAGGDIDSRLFRAPYGSTDQNIYSMLSRSGIVADFSYSDHYNTYRDGNFVRFNVTSFEGAKAGPEPLLNLDSRQPVMVIFDNNSVPISEVDKFIDRVMTGHHAQYDPKFVNASDLAQMQLTLREKAEEGEGREP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MST3</accession>
    <name>A0A075MST3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AN1-like Zinc finger</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700825.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MST3"/>
    <dbReference type="GeneID" id="41597880"/>
    <dbReference type="KEGG" id="nev:NTE_02156"/>
    <dbReference type="HOGENOM" id="CLU_2875209_0_0_2"/>
    <dbReference type="OrthoDB" id="8731at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="65" mass="7748" checksum="B0B37A1F3E2E2CFA" modified="2014-10-29" version="1">MRPPQKPQKQQTPKSSRKDYDYNKPIGKCVVCYTLSGWHCYECGNDFCQAHYHEHKDRNQCKPMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSX5</accession>
    <name>A0A075MSX5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00357</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699414.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSX5"/>
    <dbReference type="STRING" id="1459636.NTE_00357"/>
    <dbReference type="GeneID" id="41596249"/>
    <dbReference type="KEGG" id="nev:NTE_00357"/>
    <dbReference type="HOGENOM" id="CLU_084395_0_0_2"/>
    <dbReference type="OrthoDB" id="12176at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13412">
        <property type="entry name" value="HTH_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="242" mass="26642" checksum="25BB4B10818A1A87" modified="2014-10-29" version="1">MPSDGQKASIVEATIYAPPSSSSSNKNNNNNTSRLALEQELAKIDVNPEFFKTLTVDQLADLLFGLNRAINANAGSAAGRRITKKLAGSTLSSIDKKILKALLELRGNPSSLQLSRELDIPLSTVQRRRKRLEDEFVNEFYSLQYEKFGKRQVTFIVSLGAVDKNAIANEILGLEKVIAVARTFGDGADLKVEAILESNQEFMETSEKIKAIPGIQKVCWFESLELLGRKKELDLSIVEGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MT06</accession>
    <name>A0A075MT06_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fe-S oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02276</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MT06"/>
    <dbReference type="STRING" id="1459636.NTE_02276"/>
    <dbReference type="KEGG" id="nev:NTE_02276"/>
    <dbReference type="eggNOG" id="arCOG01357">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032214_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="entry name" value="tm_1862 like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42731:SF4">
        <property type="entry name" value="RADICAL SAM DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42731">
        <property type="entry name" value="SLL1084 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01082">
        <property type="entry name" value="B12-binding_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Elp3/MiaA/NifB-like radical SAM core" evidence="1">
        <location>
            <begin position="216"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="527" mass="59219" checksum="5D18A82BB8A1E4B8" modified="2014-10-29" version="1">MVVSGGKRIVLTADRSLMTNYRGNFLYGFIACGPYELVPEFVFDKIFCPSVETDNATGGVKVAQCGLRRIEGALLKEYRRDDIFLAHPEMLEKCIGPETKVVGINVMDPLGMAPVTTTMSPEKLSYVAMKFKKMCASIIQLKKKYNFKVVVGGNGSWELAKPDRMKIHGIDTVVIGEADELALDLFHDLEAGDAPELLHTFVRNIENVPMMQGPTVNSLIEAMRGCGRGCDFCDVNKRTKKDFPLERLQQEAKLNLDYGFDSIWLQSDEMLLYGCDNKDFVPNADAITHLWSGLKSTGARFVGTTHMTLSAVASSPDLIKKLSQINEMDVAGGRWLATNLGIETVAPRMVKKHLGVKTKPFQPEEWGAVVREGCKVLNDNHWFPALTLIIGWPDETPDETQYTIDLIEDFKQTNMRGIVAPLLYQDFSEKNSMHFGNLNEAQFTLFWMCWQHNLRVINDIIPIIIRNKSYGPMMKVFMALLIKAGTWAIMKYLRGLSKDLFAGQLPEDIVARYTNKRSVTAPLPKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MT11</accession>
    <name>A0A075MT11_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02287</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_144239470.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MT11"/>
    <dbReference type="STRING" id="1459636.NTE_02287"/>
    <dbReference type="GeneID" id="41598002"/>
    <dbReference type="KEGG" id="nev:NTE_02287"/>
    <dbReference type="HOGENOM" id="CLU_2645694_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="76" mass="8205" checksum="F01D7B263C22407E" modified="2014-10-29" version="1">MLTFFCKRDRHVDCPGEWPVGESCGPDHDCSFDMRMMKCACKCHVEKKNVAAQPSTTTAAAKRATAASKRAGAAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MT15</accession>
    <name>A0A075MT15_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01878</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700616.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MT15"/>
    <dbReference type="GeneID" id="41597637"/>
    <dbReference type="KEGG" id="nev:NTE_01878"/>
    <dbReference type="HOGENOM" id="CLU_2177771_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="109" mass="12766" checksum="689828BC233056B6" modified="2014-10-29" version="1">MRNLQLDNAEKASINEYLDKSIRDLKVAKPQHPEAQKVDEEFLGSTSRAAEMWFIENDVIHDIRHGYVLIFRCRHGRFPMDMEFQAIMREIGKREPEIRSLVRSLGAHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MT47</accession>
    <name>A0A075MT47_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01918</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MT47"/>
    <dbReference type="KEGG" id="nev:NTE_01918"/>
    <dbReference type="HOGENOM" id="CLU_1472031_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="183" mass="18873" checksum="95E5E42A49AB6376" modified="2014-10-29" version="1">MVGMEETVETAEIAATTVLTIAIVAAAMVETAAMAEMEATHSVQAATTIAAVETAAQVEMEAMVVMVEMTVPITAIAAVETVETAAMAEMEATHSVQAATMTVAAAMEVREAMAEMEAMAATTVLTIAIAAAAMEVMEATVETVETHSVQAATTIVAARNSVQVTTGIVPTDAETKSRNTRYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MT53</accession>
    <name>A0A075MT53_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Endonuclease III</fullName>
            <ecNumber evidence="12">4.2.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">DNA-(apurinic or apyrimidinic site) lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">nth</name>
        <name evidence="14" type="ORF">NTE_02683</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Hydrolyzes mismatched double-stranded DNA and polynucleotides, releasing free thymine.</text>
            <dbReference type="EC" id="3.2.2.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the Nth/MutY family.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="12"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MT53"/>
    <dbReference type="STRING" id="1459636.NTE_02683"/>
    <dbReference type="KEGG" id="nev:NTE_02683"/>
    <dbReference type="eggNOG" id="arCOG00459">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012862_3_4_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141016">
        <property type="term" value="F:G/T mismatch-specific thymine-DNA glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000703">
        <property type="term" value="F:oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.30:FF:000001">
        <property type="entry name" value="Endonuclease III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00942">
        <property type="entry name" value="Nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004036">
        <property type="entry name" value="Endonuclease-III-like_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003651">
        <property type="entry name" value="Endonuclease3_FeS-loop_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005759">
        <property type="entry name" value="Nth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43286">
        <property type="entry name" value="ENDONUCLEASE III-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43286:SF1">
        <property type="entry name" value="ENDONUCLEASE III-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00525">
        <property type="entry name" value="FES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01155">
        <property type="entry name" value="ENDONUCLEASE_III_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="14" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 12" id="KW-0408">Iron</keyword>
    <keyword evidence="7 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="13">
        <location>
            <begin position="59"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00052915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AIF84726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="242" mass="27319" checksum="6457EB819A68E748" modified="2014-10-29" version="1">MAKKGRTATTKNKKMAMGEILRRMEAALYRENPPRLTALRGLQKEENGDPFRILIGTILSARSRDEYTTKVVNKLFATYRTPEELASADLDDLKKLIHSIGFYNVKAARIKQVAQAIVEKFGGIVPSDIDKLLELPGVGRKTANCVLVYAFDKPAIPVDIHVHRISNRLGLVETKTPEQTEEELSRMVDRRLWTKVNDTFVMYGQNICLPVKPNCRVCDLKSVCRYYATTTTISSSSTKERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTA1</accession>
    <name>A0A075MTA1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02744</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTA1"/>
    <dbReference type="STRING" id="1459636.NTE_02744"/>
    <dbReference type="KEGG" id="nev:NTE_02744"/>
    <dbReference type="HOGENOM" id="CLU_3263611_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="41" mass="4935" checksum="3F96CEB16E59C46A" modified="2014-10-29" version="1">MIEERRVNAEERDTRIFAAKACNRLKNILWTFDGQYIVVYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTB4</accession>
    <name>A0A075MTB4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GYD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701320.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTB4"/>
    <dbReference type="GeneID" id="41598459"/>
    <dbReference type="KEGG" id="nev:NTE_02770"/>
    <dbReference type="eggNOG" id="arCOG11305">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_178999_0_0_2"/>
    <dbReference type="OrthoDB" id="7321at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="102" mass="11390" checksum="2CB9742AB569D5DA" modified="2014-10-29" version="1">MALFGVFATHSPESCPLNNKQSKDTMIMIDDKIKSITEKFHVRKIHGFYMSVLEHEWVIIVEADSPHEIEAMCIEAGISAFNTVKIVPLSNFDAVVKKVKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTE2</accession>
    <name>A0A075MTE2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02821</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701363.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTE2"/>
    <dbReference type="STRING" id="1459636.NTE_02821"/>
    <dbReference type="GeneID" id="41598506"/>
    <dbReference type="KEGG" id="nev:NTE_02821"/>
    <dbReference type="HOGENOM" id="CLU_117972_0_0_2"/>
    <dbReference type="OrthoDB" id="12047at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="209" mass="21658" checksum="F9F54995CE97074D" modified="2014-10-29" version="1">MTRMSQGDSGTKIKASMMTKHRFLATAMTGILLTAAFSAAWVTTTIGTANAQVVVGESTIARDSVLLTGPLTIPAGGFMHVYDATPYHIMKGHIALQVPCDAQHNASVQVLIGQAPDLKPANLEFVSQLSTPGEQCMYHVDIASHDDPNNPIITDVAIKNAGSEDVQLTDTSTVFVGVDEIMPNLAAAEQGGAEGGGGGGMNMTEGGGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTK2</accession>
    <name>A0A075MTK2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Urease, beta subunit</fullName>
            <ecNumber evidence="2">3.5.1.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02913</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
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    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="KEGG" id="nev:NTE_02913"/>
    <dbReference type="eggNOG" id="arCOG04527">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129707_2_1_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035550">
        <property type="term" value="C:urease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009039">
        <property type="term" value="F:urease activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="P:urea catabolic process"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00407">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.150.10">
        <property type="entry name" value="Urease, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002019">
        <property type="entry name" value="Urease_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036461">
        <property type="entry name" value="Urease_betasu_sf"/>
    </dbReference>
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        <property type="entry name" value="Urease_subunit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009682">
        <property type="entry name" value="PRK13203.1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UREASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33569:SF1">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00699">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51278">
        <property type="entry name" value="Urease, beta-subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="121" mass="13147" checksum="7FBF8CE719796081" modified="2014-10-29" version="1">MPGEYFIISDKLVMANPGRRTTRVSVSNTGSRPVQVGSHTHFFEVNKALSFPREKAYGFHLNIPAGTSLRFEPGDTREVELVEYGGRKIVHGFSGLVNGKLSAAKKKEALAKARARGFAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTM7</accession>
    <name>A0A075MTM7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02071</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTM7"/>
    <dbReference type="KEGG" id="nev:NTE_02071"/>
    <dbReference type="HOGENOM" id="CLU_2550072_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="82" mass="9591" checksum="C1817680307598DB" modified="2014-10-29" version="1">MRVSDMFGKTQSFLFRQIRDITQNIEYDTVATIFDNCRHPGCGSETCAMNWIVRVPLNIAIHTILFYIFKQHGFKCYGLVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTN7</accession>
    <name>A0A075MTN7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Formate hydrogenlyase subunit 3/multisubunit Na+/H+ antiporter, MnhD subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NTE_02453</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701068.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTN7"/>
    <dbReference type="STRING" id="1459636.NTE_02453"/>
    <dbReference type="GeneID" id="41598160"/>
    <dbReference type="KEGG" id="nev:NTE_02453"/>
    <dbReference type="eggNOG" id="arCOG01537">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007100_10_1_2"/>
    <dbReference type="OrthoDB" id="19089at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052175">
        <property type="entry name" value="ComplexI-like_HydComp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003918">
        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42682">
        <property type="entry name" value="HYDROGENASE-4 COMPONENT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42682:SF5">
        <property type="entry name" value="HYDROGENASE-4 COMPONENT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01437">
        <property type="entry name" value="NUOXDRDTASE4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="391"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="433"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="485"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="NADH:quinone oxidoreductase/Mrp antiporter transmembrane" evidence="8">
        <location>
            <begin position="143"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF84503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="540" mass="57965" checksum="F992586FB7B2AA7D" modified="2014-10-29" version="1">MTEWALLVGATSAAFPTASSVLIFSLLLTPVAGALFVTLFRKKRAAELITVVSASLILIQALGLVADVIVEKKISAFGELFFFDAFGALIMLPIAGVGFVSALYSINYMGRQYEHGLVDDKHIIRYYQGFNVFLLTMLLVPVSNNMGAMWVAIEATTLVSVLLIMLYTKESAIEAAWKYLIIATVGLSFALFGTVFFYYANVTAISPSAEAEPSSAMNWTDMVSHSKLLNPDIVKIAFIFILVGFGTKAGLAPMHTWLPDAHSEAPTPVSALLSGVLLNCSIYSIIRYHIITSGTVGSAFSNQLLIILGVVSVGIAAASIYFQKDMKRMLAYSSVEHMGIVSLAMGFGGFIGIYGALLHIINHAIAKPLMFFASGTISQKYETKTMSGIRGIIKIMPITGVLFLIGGLAIVGMPPFNIFVSEFMILSSGFGSGQFVASSLVITFLVIIFAAFMRHLIKMVFGSPKESGRGMSEDSIAKKDEMGKLAIIPMIILAIFAVILGFYIPSPIQTLANDVMQIFNQGSIAAAFPTSDLVSGVESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTQ0</accession>
    <name>A0A075MTQ0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00578</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTQ0"/>
    <dbReference type="STRING" id="1459636.NTE_00578"/>
    <dbReference type="KEGG" id="nev:NTE_00578"/>
    <dbReference type="HOGENOM" id="CLU_2695530_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="73" mass="8199" checksum="B8AAE98233BB73E1" modified="2014-10-29" version="1">MTIIIANRTCVILVMSTLVVQALLISAPRIARIVSFTFMAASHLILLFFPSSVFRMVIAETTYKTDWLVIIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTY6</accession>
    <name>A0A075MTY6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycogen debranching enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03092</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987035.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTY6"/>
    <dbReference type="STRING" id="1459636.NTE_03092"/>
    <dbReference type="GeneID" id="41598753"/>
    <dbReference type="KEGG" id="nev:NTE_03092"/>
    <dbReference type="eggNOG" id="arCOG03287">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_591361_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="462" mass="51685" checksum="BE945B3AFDCCCBF3" modified="2014-10-29" version="1">MGDVTVPPPVDGLWHSFSANAGAFVESTEQFVQEGVNPGGYYKAVWCRDASYILKDWFLSGRFEDVMHELLFIWSHQVTAGGEKVIYGRGSPEMRYISQVADPETHKKFEGALPSTIFRGFSEIYGRNPDIDSTALMISTTAWIFNVYLKSGMVIPAPSSPSHGNIELKMSSLVSSPSIVMEYVVPRMLMAMDYLASRDIDGDGLLEQGHNEDWMDTVLRSGKIVYSQACWILALSNLSSLLLELDRKDEAKRAMSMAYRTIKAVESRLWSEKDGVYIDYLQDSGGDGDGQHGTLTQDIALYLVAVTENTTQDILGSGQIREEPAQDEKARPEFGSRAGRALDTLRARIWKDKWPLVTESALERTGPWILNPNQYHNHTFWPWTTGIEMLARSRFSRVHECHELLSMLASNDCQSNKRAFYEWVNPVTNTGSGAHPFRTGISAIRIAIADILGQMGKPSLTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTZ9</accession>
    <name>A0A075MTZ9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00649</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699642.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTZ9"/>
    <dbReference type="STRING" id="1459636.NTE_00649"/>
    <dbReference type="GeneID" id="41596512"/>
    <dbReference type="KEGG" id="nev:NTE_00649"/>
    <dbReference type="eggNOG" id="arCOG04151">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048986_0_1_2"/>
    <dbReference type="OrthoDB" id="31282at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007254">
        <property type="entry name" value="DUF373"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38815:SF1">
        <property type="entry name" value="DUF373 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38815">
        <property type="entry name" value="HYPOTHETICAL MEMBRANE PROTEIN, CONSERVED, DUF373 FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04123">
        <property type="entry name" value="DUF373"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="326"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="400" mass="43098" checksum="BBE20AF52C1F981A" modified="2014-10-29" version="1">MPSQPDYYARNHKLEVPKSQDSSQSRLLVLCIDRDDDIGTKGGIETPIVGRDQCINAGTRLAIEDPEDADGNAIFGAVKTYEELVSKGYNVEVAVVAGKFNRGVEADEKISREVQAILEKYNATGAVIVSDGEDDETVLPVIQSRVPVVSVQRIIIRHSRSVEYSYAVFGRYLKAMMYDPQYSKFFLGVPGTLLLAGGLAVAFDATKWLTVMILAILGGAFMVRAFDVDRAISSLGKMGPTDFIKIFSIIGGVLMMLAAIANGISSIPHDIPVSQMDALQIITNKTIVGSFTKGMITMMWIGIATVMAGVLLSNWLKGSSHAMADILRLVVLGLLYIPVLQFTDVLTLSTSPFTLVSSLLIGLAVSLVAAAFLYQHFRHRRGGEQVKANGGSSGSNNGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MU66</accession>
    <name>A0A075MU66_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Menaquinone biosynthesis decarboxylase, SCO4490 family</fullName>
            <ecNumber evidence="5">4.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_00786</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UbiD family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699751.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MU66"/>
    <dbReference type="STRING" id="1459636.NTE_00786"/>
    <dbReference type="GeneID" id="41596636"/>
    <dbReference type="KEGG" id="nev:NTE_00786"/>
    <dbReference type="eggNOG" id="arCOG01671">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023348_4_1_2"/>
    <dbReference type="OrthoDB" id="8480at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1670.10:FF:000002">
        <property type="entry name" value="Menaquinone biosynthesis decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1670.10">
        <property type="entry name" value="UbiD C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022390">
        <property type="entry name" value="HBDC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002830">
        <property type="entry name" value="UbiD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049381">
        <property type="entry name" value="UbiD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049383">
        <property type="entry name" value="UbiD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048304">
        <property type="entry name" value="UbiD_Rift_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03701">
        <property type="entry name" value="mena_SCO4490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00148">
        <property type="entry name" value="UbiD family decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30108">
        <property type="entry name" value="3-OCTAPRENYL-4-HYDROXYBENZOATE CARBOXY-LYASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30108:SF17">
        <property type="entry name" value="FERULIC ACID DECARBOXYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01977">
        <property type="entry name" value="UbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20696">
        <property type="entry name" value="UbiD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20695">
        <property type="entry name" value="UbiD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143968">
        <property type="entry name" value="UbiD C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-octaprenyl-4-hydroxybenzoate carboxy-lyase-like N-terminal" evidence="3">
        <location>
            <begin position="10"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="3-octaprenyl-4-hydroxybenzoate carboxy-lyase-like Rift-related" evidence="2">
        <location>
            <begin position="121"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="3-octaprenyl-4-hydroxybenzoate carboxy-lyase-like C-terminal" evidence="4">
        <location>
            <begin position="324"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF82864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="484" mass="53967" checksum="951E5A263A64E365" modified="2014-10-29" version="1">MPFESLGEYVDALERAGELKRVRAKVSADLEIAEVMRRLMYKGDQPAVLFENVEGSDMQVLGNAFGTMKRLKLALESEDFVDIGQRIVDLTRMKMPSGMFNKLKMLPKLSEIGEYGPKYEDKGPVTEVVEGGDKASFNSLPILQSFAGDAGRFITFGMTVTKHPETEIRNLGVYRVQIVDDKHAIMHWQTHKRGAQHYKMLKEQNKKIQAAIVIGADPATVFSAVAPVPEGMDKYLFAGITRKKGVKLVKCRTVDLEVPANAEIVLEGYVDPNDMRMEGPFGDHTGYYTPAEPFPTFTLTGIMRRRNPIYLTTVVGKPVLEDAYIGKVIERSFLPLIQMFHPEVVDFSMPGAGWFQGLAVISIKKTYPGQAKKVMMGLWGMGQLALTKMFVVVDSDVDVHDANDVIWAVTTRADAARDTVIINNAPTDTLDPASPLVNLGSKMGIDATQKTREEGYMREIQQLAVVDDKTKALVDRRWQEYFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MU80</accession>
    <name>A0A075MU80_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00811</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MU80"/>
    <dbReference type="KEGG" id="nev:NTE_00811"/>
    <dbReference type="HOGENOM" id="CLU_1280731_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="215" mass="23531" checksum="B6674069C65F876F" modified="2014-10-29" version="1">MEETRKKQNNKISQPSNSLVLLRKGWSIRRLWILSIIGVAGLGLDASFHTLANGTPLSIIFDGADFSTNQIILTTTPAIATLSWTGHITFLTAFTLLGILPVLFFEKFAPARSSDQGGRRWAILKKGRNIKQMWIIGLIGVAGLALDVSFHWLQDGDPSKVVLNGFEDPRPLVSMLAISAHMMFLGAFALLIFLPKILIAAQHPPTTTVAMSPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUA9</accession>
    <name>A0A075MUA9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00848</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUA9"/>
    <dbReference type="KEGG" id="nev:NTE_00848"/>
    <dbReference type="eggNOG" id="arCOG03910">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1178160_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="202" mass="22760" checksum="02BA31078E8E0738" modified="2014-10-29" version="1">MESASKAQRAVAEHVVAREVPPNRRQEILEYLKLFGYKPERTVIQVHITGFFGKKGGGAAAPREAAKREAAAKRYGGTTFVVVGRTHDPAIMEQVTKPRKSAKDASPGYVGYLWQNRDPQLRPPHEAIPLDFTPVHVPYPKDWKDVFATKGFLLAMHVPSSFAKEKSSLTRALYRLGKNADAREPWTFLKELKNFGYKPEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUB0</accession>
    <name>A0A075MUB0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02248</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUB0"/>
    <dbReference type="STRING" id="1459636.NTE_02248"/>
    <dbReference type="KEGG" id="nev:NTE_02248"/>
    <dbReference type="HOGENOM" id="CLU_3263610_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="41" mass="4790" checksum="9C74C36A1F8D802E" modified="2014-10-29" version="1">MIDFVGKSAYAILDSLIAIYHTSIESMFKNIWHRQFRNNSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUP2</accession>
    <name>A0A075MUP2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00954</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUP2"/>
    <dbReference type="STRING" id="1459636.NTE_00954"/>
    <dbReference type="KEGG" id="nev:NTE_00954"/>
    <dbReference type="HOGENOM" id="CLU_2299211_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="100" mass="11065" checksum="085EF0FD8031A26E" modified="2014-10-29" version="1">MTLSDSDRGKLDKAIDTAVSLAPVYTELATSQIGKDTMKITNGRDFVLGCAFATVIRLLYFTGKSEDVFTSDHAVEMLAVMRRRFFAEIDILKVPKSNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUU7</accession>
    <name>A0A075MUU7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03408</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701848.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUU7"/>
    <dbReference type="STRING" id="1459636.NTE_03408"/>
    <dbReference type="GeneID" id="41599053"/>
    <dbReference type="KEGG" id="nev:NTE_03408"/>
    <dbReference type="HOGENOM" id="CLU_1551750_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019668">
        <property type="entry name" value="Uncharacterised_YtzC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10732">
        <property type="entry name" value="DUF2524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="172" mass="17948" checksum="609C125B3202F18C" modified="2014-10-29" version="1">MMSSTSKSTRSKKTILLSAIFAMAVLLLGASSSAISAKAWAQAPTADIKSKAKEIENTVISALKSYATGIGAKYIDLDLLTQAPPTTGNNTGGGVPTVVNQTAYTDAMNMIAKAQNQLQSLSQTANPQQATLIAKAQGGVEALKTLMERKAPINLAEDVAQSPIVNNLRQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUW9</accession>
    <name>A0A075MUW9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03428</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701864.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUW9"/>
    <dbReference type="STRING" id="1459636.NTE_03428"/>
    <dbReference type="GeneID" id="41599069"/>
    <dbReference type="KEGG" id="nev:NTE_03428"/>
    <dbReference type="HOGENOM" id="CLU_1912247_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="132" mass="14232" checksum="856A47A3D8A58C9D" modified="2014-10-29" version="1">MGIGIPPIVGLLSGAKCNPVTDYPKINGMSAAVTDWECKNNDQVSLSFKQKTIGLQTDKHTIVFLYMSSAPVYYDKHLTEFNRSIETLKIPDTIGPPSTPEFSSGTMLGVTTAATIGFIAFFLPCRSGLIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MV01</accession>
    <name>A0A075MV01_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AAA+ family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NTE_03020</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701524.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MV01"/>
    <dbReference type="STRING" id="1459636.NTE_03020"/>
    <dbReference type="GeneID" id="41598690"/>
    <dbReference type="KEGG" id="nev:NTE_03020"/>
    <dbReference type="eggNOG" id="arCOG01307">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_21_2_2"/>
    <dbReference type="OrthoDB" id="77269at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001054">
        <property type="entry name" value="ATPase, AAA family, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007330">
        <property type="entry name" value="MIT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF83">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00745">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIT" evidence="7">
        <location>
            <begin position="5"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="165"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="76"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="77"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="97"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF85055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="409" mass="45448" checksum="7B96D6C217051E89" modified="2014-10-29" version="1">MSLAPQELENSASKYAAEAIRLDSQGSRGMAIQSYQRAIEALVKLVQIYPDYKLNKVYMERANAYQNRIKALQMSHGLDDDRPTPIEDNRVEPANGNGKGSAPSGGSGSKSGNVETLKADFDDLVMKDKPKVSWDEVIGLDDAKRAIRESIVYPMKRPDLFPLGWPRGILLYGPPGCGKTLLAAAAAAEIDGYFINVDAASMMSKWLGEAEKNISKLFTMARKLNESEGVPVLLFIDEIDSLLGQRNSEVGGEVRVKNQFLTEMDGINGKSKESQLYVIGATNKPWSLEAGFLRRFQKRIYVTLPDNASRTNLFNQYTRPLNTESALKIDELAKITDGYSASDIKDICQSVQLRVVNELFESGKAMEANANPRPVGTTDFREILKIRKPSVSVDMIRAYMRWSDQFKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MV38</accession>
    <name>A0A075MV38_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peroxiredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_02473</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701081.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MV38"/>
    <dbReference type="STRING" id="1459636.NTE_02473"/>
    <dbReference type="GeneID" id="41598178"/>
    <dbReference type="KEGG" id="nev:NTE_02473"/>
    <dbReference type="eggNOG" id="arCOG00314">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076204_1_0_2"/>
    <dbReference type="OrthoDB" id="334137at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02969">
        <property type="entry name" value="PRX_like1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047262">
        <property type="entry name" value="PRX-like1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43640">
        <property type="entry name" value="OS07G0260300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43640:SF1">
        <property type="entry name" value="THIOREDOXIN-DEPENDENT PEROXIREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="11"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF84522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="182" mass="20113" checksum="04301470C80CE0ED" modified="2014-10-29" version="1">MARTLSSPQVLKTGASAPSFQLKGVDGKTHSLSEYKSKATLVVFICNHCPFVKARIGDIVALQSKFKPSELQVIGINSNDPSYQDEGFDNMVKFSKEYGLNFPYLIDESQDVARAYGAVCTPDPFLFVDGKLAFHGRINDAMEPEAKPTVPVMENNIRALFTGKKLEKDFDPSIGCSIKWKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MV53</accession>
    <name>A0A075MV53_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03503</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701914.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MV53"/>
    <dbReference type="GeneID" id="41599126"/>
    <dbReference type="KEGG" id="nev:NTE_03503"/>
    <dbReference type="HOGENOM" id="CLU_1269866_0_0_2"/>
    <dbReference type="OrthoDB" id="387476at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="217" mass="25312" checksum="56E1189153574335" modified="2014-10-29" version="1">MSKQTLKRRRIVTLVLIVLGAASIMSLAVAPTSAHASKGSEYYYKNCGYWKETEKSTDYEYKLKKSHDSKENEKESGFGKSYEGDEKSEDDDKNDRDSGGHYHKDKDASYDNNRNDDKNDDNGKDHKDKSSYDYSSGSGSKDSSDYEKYKGDHTYRYEFEKKNTMERHDGDKWCDTEDDNDKDRYHGDRDRDHDHYGKEHNNKHDDEEDDKENDDDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MV78</accession>
    <name>A0A075MV78_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zinc-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03033</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987029.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MV78"/>
    <dbReference type="STRING" id="1459636.NTE_03033"/>
    <dbReference type="GeneID" id="41598702"/>
    <dbReference type="KEGG" id="nev:NTE_03033"/>
    <dbReference type="eggNOG" id="arCOG08820">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2949111_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.30">
        <property type="entry name" value="RNA polymerase ii, chain L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="60" mass="6954" checksum="3E1719802FD7FD42" modified="2014-10-29" version="1">MLEAKCPKCGKRAQVDDDMANVRCDFCGYSATYDEYIELMKGKAVTMADDYQMNWDRNPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MV93</accession>
    <name>A0A075MV93_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700004.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MV93"/>
    <dbReference type="STRING" id="1459636.NTE_01121"/>
    <dbReference type="GeneID" id="41596935"/>
    <dbReference type="KEGG" id="nev:NTE_01121"/>
    <dbReference type="HOGENOM" id="CLU_119856_0_0_2"/>
    <dbReference type="OrthoDB" id="381940at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="164" mass="18049" checksum="E3E526CEF02327FB" modified="2014-10-29" version="1">MSGKLRDIRETASDAIEIIHEIGTPEVRSSLDKIKDTTKEVREIIQALSTPEMVKNMENMRLTAESMQDAASRMENTFKELKESGVLDEVKKTSESARNVMDSFGSAAGGNNSEVMQASKETVQAVKELVQELKLAISDSRKSGVIKNVNETVKEISSLKDTVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVB5</accession>
    <name>A0A075MVB5_9ARCH</name>
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        <submittedName>
            <fullName evidence="6">NADH dehydrogenase subunit H</fullName>
            <ecNumber evidence="6">1.6.5.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NTE_02555</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.6.5.3" evidence="6"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701143.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVB5"/>
    <dbReference type="STRING" id="1459636.NTE_02555"/>
    <dbReference type="GeneID" id="41598250"/>
    <dbReference type="KEGG" id="nev:NTE_02555"/>
    <dbReference type="eggNOG" id="arCOG01546">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015134_0_1_2"/>
    <dbReference type="OrthoDB" id="15253at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01350">
        <property type="entry name" value="NDH1_NuoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001694">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su1/FPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018086">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11432">
        <property type="entry name" value="NADH DEHYDROGENASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11432:SF3">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00146">
        <property type="entry name" value="NADHdh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00668">
        <property type="entry name" value="COMPLEX1_ND1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="393"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF84602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="421" mass="46356" checksum="146061A4C3033D80" modified="2014-10-29" version="1">MAYTESFRFGEFIGSVLWLVFWILIIFSLVGLPLLFVVLFYVPLPPVNGAPLTPYLFLTMTVDPTRTIPIIKYMIHTDLFRVAAFPGFTYAALFAAVTIFVERKFLAKMQLRYGPLYVGKIEGWLQLIADGLKLISKEIIVPSGADKPLFWAAPIAFVSTAAAVTALIPVAPGWVVANVDVGLLAVFAILGFFPLIALLFSWASNSKYPFIGGLRALHQIIAFEIPFIISALSVVILAGTLNLTGIVNAQISSYWYIFFLPISAFVFYLSSLAELERIPFDLPEAESEIVAGWITETSGMIYGLIQLGSYVKTYALAALFVVLFLGGWAGPVIFPQEIIPGYTGDKIYNPVTLSAIVWFTVKTFGVIMLMLLPRGISPRIRIDILLHTGWYKLIVLSFINMFVALALIYGGILGPGGLLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVG2</accession>
    <name>A0A075MVG2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02609</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVG2"/>
    <dbReference type="STRING" id="1459636.NTE_02609"/>
    <dbReference type="KEGG" id="nev:NTE_02609"/>
    <dbReference type="eggNOG" id="arCOG08800">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="165" mass="18082" checksum="F97B6ECA8DE1A50C" modified="2014-10-29" version="1">MARDSIPVKVLSIGLAGCILGIFCTVSNMSPAYASDFEVIRLNHDPIVTTIENADEKITKLERGQQTVIEIAAHNNMAASQHFVMVVEVRDGRGVTEYLAWQEGVAEPDSDFEIKFSWSPEQTCEFYEDCAKREIRSFAMSSLTEPRSVSSIATTGGITISGIST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVG3</accession>
    <name>A0A075MVG3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01176</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700045.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVG3"/>
    <dbReference type="GeneID" id="41596987"/>
    <dbReference type="KEGG" id="nev:NTE_01176"/>
    <dbReference type="HOGENOM" id="CLU_1253520_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="220" mass="23698" checksum="7FCCF233B1394EFD" modified="2014-10-29" version="1">MQKKTTTIVMAALIACVVAIGAIYASNNLALQPNGTGSKAVGSDFQTVSAEQFCQTREEALAKTEGKIQVKEPTYLPAEYKFVCGDGSPDVVLMFYGGGRPLEKSQLNRNGLIESGAVLVATKHAEPDIPDRKAEIEASFQGVNPDLKTRITEINGNVAAVREQCQDCGKGFLTYENGTTVQTGSFGLTSIIVFYDGNQKYLLEAYMPSDELEKIAKSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVL2</accession>
    <name>A0A075MVL2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01249</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700108.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVL2"/>
    <dbReference type="GeneID" id="41597055"/>
    <dbReference type="KEGG" id="nev:NTE_01249"/>
    <dbReference type="HOGENOM" id="CLU_3003267_0_0_2"/>
    <dbReference type="OrthoDB" id="6503at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="59" mass="6806" checksum="4F0669732AAFF87A" modified="2014-10-29" version="1">MGIITMQLVCDTCKKVILEKEGEEHLMNERFPITGEEAKKLDLEHRGHECHIEAVEKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVL4</accession>
    <name>A0A075MVL4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">3-isopropylmalate dehydratase, small subunit</fullName>
            <ecNumber evidence="4">4.2.1.33</ecNumber>
            <ecNumber evidence="4">4.2.1.35</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_01254</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LeuD family. LeuD type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="4"/>
    <dbReference type="EC" id="4.2.1.35" evidence="4"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700112.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVL4"/>
    <dbReference type="STRING" id="1459636.NTE_01254"/>
    <dbReference type="GeneID" id="41597060"/>
    <dbReference type="KEGG" id="nev:NTE_01254"/>
    <dbReference type="eggNOG" id="arCOG02230">
        <property type="taxonomic scope" value="Archaea"/>
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    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047508">
        <property type="term" value="F:(R)-2-methylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01577">
        <property type="entry name" value="IPMI_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033940">
        <property type="entry name" value="IPMI_Swivel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050075">
        <property type="entry name" value="LeuD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011827">
        <property type="entry name" value="LeuD_type2/HacB/DmdB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02087">
        <property type="entry name" value="LEUD_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43345:SF2">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDRATASE SMALL SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43345">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDRATASE SMALL SUBUNIT 2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="3">
        <location>
            <begin position="47"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF83324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="166" mass="18538" checksum="740AA6C9039F39AE" modified="2014-10-29" version="1">MNKTLRGRVHKYERDNIDTDVIIPGPYLKIHDHKELAKHAMEGIDPKFPEKVQQGDFLVTGSNFGCGSSREHAPIALSQTGIKAILAPTFARIFYRNAVDGGYLLPIEIDAATVKKISDKDELEIDLARNRITNVTKNEQYSMKPFPELIAKIVEAGGLMKYKPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVR0</accession>
    <name>A0A075MVR0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03311</name>
    </gene>
    <organism evidence="1 2">
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        <lineage>
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            <taxon>Nitrososphaerales</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
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    </dbReference>
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    </dbReference>
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    <dbReference type="STRING" id="1459636.NTE_03311"/>
    <dbReference type="GeneID" id="41598962"/>
    <dbReference type="KEGG" id="nev:NTE_03311"/>
    <dbReference type="eggNOG" id="arCOG08782">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_202921_0_0_2"/>
    <dbReference type="OrthoDB" id="5631at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="73" mass="8409" checksum="A9CE0E5DE789D17B" modified="2014-10-29" version="1">MVRKFDDWWKTVPADLKAKARKGDESNKPLLNQVNYVLLHLHLAGKHDAKPTHEELKDWLHSGQVDVLRQGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWA5</accession>
    <name>A0A075MWA5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWA5"/>
    <dbReference type="STRING" id="1459636.NTE_03390"/>
    <dbReference type="KEGG" id="nev:NTE_03390"/>
    <dbReference type="HOGENOM" id="CLU_2165144_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="110" mass="12631" checksum="0B6A471BCAFA66FD" modified="2014-10-29" version="1">MSRMMKLSSCARLRRCSVMTESTLSDIEARLRIYSALKKANDKDDELEPITAEIINRIGERTRVMAGVRKLLKQDLKTCINMLEFPADYKDEVKSLQLVRNTANLIIKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWE9</accession>
    <name>A0A075MWE9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWE9"/>
    <dbReference type="KEGG" id="nev:NTE_01541"/>
    <dbReference type="HOGENOM" id="CLU_213585_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="11"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="53" mass="6254" checksum="0D3296911B3B95DE" modified="2014-10-29" version="1">MRLLPMAVSGYRHTDKSRQELIEEIARLKEKLKAKDEEIGLLKKRLALYKTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWH1</accession>
    <name>A0A075MWH1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01561</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700361.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWH1"/>
    <dbReference type="STRING" id="1459636.NTE_01561"/>
    <dbReference type="GeneID" id="41597343"/>
    <dbReference type="KEGG" id="nev:NTE_01561"/>
    <dbReference type="HOGENOM" id="CLU_2490576_0_0_2"/>
    <dbReference type="OrthoDB" id="378087at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="87" mass="9324" checksum="FB5900058B284749" modified="2014-10-29" version="1">MQAKYLVTGIALVAVGGGLALFLNFQGYSCLSQLARIDRSTYPPAALDELERNCFIVTNSYVYSLFAVVAGAIVLAVGYKKSKSDNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWM7</accession>
    <name>A0A075MWM7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1326 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701912.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWM7"/>
    <dbReference type="STRING" id="1459636.NTE_03500"/>
    <dbReference type="GeneID" id="41599124"/>
    <dbReference type="KEGG" id="nev:NTE_03500"/>
    <dbReference type="eggNOG" id="arCOG11393">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092801_1_0_2"/>
    <dbReference type="OrthoDB" id="6311at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009758">
        <property type="entry name" value="DUF1326"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014581">
        <property type="entry name" value="UCP033303"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07040">
        <property type="entry name" value="DUF1326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033303">
        <property type="entry name" value="UCP033303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="220" mass="24168" checksum="242B649FC5EE44CF" modified="2014-10-29" version="1">MSTTTSQAASQSSVSEIPKWQMKANYVEACNCDHGCPCNFNGFPTYGFCRALVLYAIKSGSYYGNVKLDGIDVVMAASWPKAIHEGNGTAQLYISKDTTQEQRDAILKIFSGQAKGEGPFTIFASTFKYLLEPQFVDIKKNIDGKKSTFSVPSVLDVQVETFKNPVTGEEQDTQIHLPKGFIWKLGHAAKSKLMKISTPSLNFDDSGQNVIVSEVEYKGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MX87</accession>
    <name>A0A075MX87_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 11 13">1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase</fullName>
            <ecNumber evidence="5 11 13">5.3.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">hisA</name>
        <name evidence="14" type="ORF">NTE_03203</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11 13">
            <text>1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:15469"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="5.3.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 11 13">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11 12">Belongs to the HisA/HisF family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.16" evidence="5 11 13"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701668.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MX87"/>
    <dbReference type="STRING" id="1459636.NTE_03203"/>
    <dbReference type="GeneID" id="41598860"/>
    <dbReference type="KEGG" id="nev:NTE_03203"/>
    <dbReference type="eggNOG" id="arCOG00618">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048577_1_1_2"/>
    <dbReference type="OrthoDB" id="52866at2157"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00009"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003949">
        <property type="term" value="F:1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04732">
        <property type="entry name" value="HisA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000009">
        <property type="entry name" value="1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01014">
        <property type="entry name" value="HisA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023016">
        <property type="entry name" value="HisA/PriA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006063">
        <property type="entry name" value="HisA_bact_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044524">
        <property type="entry name" value="Isoase_HisA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00007">
        <property type="entry name" value="1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43090">
        <property type="entry name" value="1-(5-PHOSPHORIBOSYL)-5-[(5-PHOSPHORIBOSYLAMINO)METHYLIDENEAMINO] IMIDAZOLE-4-CARBOXAMIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43090:SF2">
        <property type="entry name" value="1-(5-PHOSPHORIBOSYL)-5-[(5-PHOSPHORIBOSYLAMINO)METHYLIDENEAMINO] IMIDAZOLE-4-CARBOXAMIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11 12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 11 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11 12" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="10 11 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AIF85232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="236" mass="24514" checksum="C4D84B8084A11B7E" modified="2014-10-29" version="1">MKVIPAIDIMGGTVVRLVKGDAQNKVVYGSDPAEMAIKWEAAGADMLHVVDLDAAFGTGSNAEAIAKVVSAVKTPVQVAGGIRTPEAAREALEKKAARVVIGTMAYSDPEAVRKLAKRHPGRVVVSIDQAGGMVMVKGWKESAGVKVNDAISQFVAIGIEDFLLTSIERDGTLAGPDIETLASAVAFSEKARIIASGGISSLEDTIRAKSVGCAAVILGKAMYDGRVSIERVKAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MXA9</accession>
    <name>A0A075MXA9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA polymerase alpha subunit C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MXA9"/>
    <dbReference type="STRING" id="1459636.NTE_03228"/>
    <dbReference type="KEGG" id="nev:NTE_03228"/>
    <dbReference type="HOGENOM" id="CLU_180000_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47789">
        <property type="entry name" value="C-terminal domain of RNA polymerase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="126" mass="14159" checksum="10EE1D3B093073C6" modified="2014-10-29" version="1">MAERRKSRTGDLDRSKPARTAKGKLKTCSRGHKFYRSCDCPVCPVCWSGYYRKQQSQNDFPDSLAALALRALLNAKITKLAQLAKHTEDEILELHGMGPKAIGQLKIAMRKHGLSFAQSRKKYSPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MXI3</accession>
    <name>A0A075MXI3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01956</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700671.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MXI3"/>
    <dbReference type="STRING" id="1459636.NTE_01956"/>
    <dbReference type="GeneID" id="41597704"/>
    <dbReference type="KEGG" id="nev:NTE_01956"/>
    <dbReference type="HOGENOM" id="CLU_1623513_0_0_2"/>
    <dbReference type="OrthoDB" id="378735at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="165" mass="17788" checksum="79D11F806A208F84" modified="2014-10-29" version="1">MVLPKSLLIVAGAVGVASILAAVFISSPSIVAAKEPFVNVTIDGLKETYKAGEPVDFVVKVKGYGCDMGFPTVVIMKQENQTQIPVWSRMGEIRLSAIGSVCESTDFYKERHIGDVQKYNKDEQERLRTVGSVPIILNGGKYAVTVEGGVVSTTVTKEFFVGATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MXP5</accession>
    <name>A0A075MXP5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03354</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701797.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MXP5"/>
    <dbReference type="STRING" id="1459636.NTE_03354"/>
    <dbReference type="GeneID" id="41599002"/>
    <dbReference type="KEGG" id="nev:NTE_03354"/>
    <dbReference type="eggNOG" id="ENOG502N58J">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_616500_0_0_2"/>
    <dbReference type="OrthoDB" id="191516at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="411" mass="46798" checksum="DFF8238510A810D7" modified="2014-10-29" version="1">MIRESSAFVKLIDEWVLEATSSGIRRFDSLLAILPGIYPVTVLESIQRLVQNNKVKSTLATEVLAYVGGKARKSQRGQILPIPHPLDFDWRFSERGIKCAMHHCKIYSKKGDMICLLGAPSLFHESSQLPDRKFILVDRNPTIASSKTGKSFYRCDLIREKLPKVSAKLVFADPPWYLEEIKSFLWAATQICEIDGHVLIVLPPVGARPGIHQEIKSVFQWARKLGLTLLDFLSGELKYQSPFFERNALRIQGINAIPSDWRKGDLAIFSKTKMRDVSRPRSSAKEPWREINVKGVRILIRNDKSNSYLDPSLISIVPSDILDSVSRRDSRRDLADVWTSGNRIFACKGRNILITILEALACGHSPVCEVESRINRRLKSDQRKKILLTVAQIIDIVDKESNERMEFERFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MXS9</accession>
    <name>A0A075MXS9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03389</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701829.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MXS9"/>
    <dbReference type="STRING" id="1459636.NTE_03389"/>
    <dbReference type="GeneID" id="41599034"/>
    <dbReference type="KEGG" id="nev:NTE_03389"/>
    <dbReference type="HOGENOM" id="CLU_1084178_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="256" mass="28366" checksum="9CCFE714C591EDB8" modified="2014-10-29" version="1">MGKYSYKNRVYVYPADDLYEKIKAEAKAQGKSLNEYVKGAIEAFANGEIVQTSKLFTGEPSTACVYGLEACTACPLRKAYPELQKPENALALLKFCNGCHIKKLAIELEKAKIKARDRINASAPPRTTTPAAVPVQQASTAPPRRIFDCINGCGCKLYWPAGPTKDNPKCRPLEAETNIVHFCPLYKPKPKTESQQVAAMVMGRVTCSVCKQGFSADSYGELERDFLDHIDKDEHRDVKDDEVEQLRKAAEVLGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MXW2</accession>
    <name>A0A075MXW2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03434</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MXW2"/>
    <dbReference type="KEGG" id="nev:NTE_03434"/>
    <dbReference type="eggNOG" id="arCOG08677">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_153621_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="138" mass="15976" checksum="3A58585508A2EF5F" modified="2014-10-29" version="1">MATTYYYTERGTKDMPMTKGDKQIVIHRDLVARLQSKWEERKVRLPQTNKTFNGFVNELLSDVIEKDEFLQKYAPALSLEGHSYNVLFIRDAKRKALAEIYRHDNKIKCALCNTFDCEHVHFALAVPEVAKLGLRNAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MY36</accession>
    <name>A0A075MY36_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_03544</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701943.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MY36"/>
    <dbReference type="STRING" id="1459636.NTE_03544"/>
    <dbReference type="GeneID" id="41599162"/>
    <dbReference type="KEGG" id="nev:NTE_03544"/>
    <dbReference type="eggNOG" id="arCOG00280">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG00371">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG02777">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_324078_0_0_2"/>
    <dbReference type="OrthoDB" id="10575at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd01127">
        <property type="entry name" value="TrwB_TraG_TraD_VirD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002789">
        <property type="entry name" value="HerA_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051162">
        <property type="entry name" value="T4SS_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30121:SF6">
        <property type="entry name" value="SLR6007 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30121">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YJGR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01935">
        <property type="entry name" value="DUF87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase HerA central" evidence="3">
        <location>
            <begin position="5"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="443"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="652"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="452"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF85572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="891" mass="99288" checksum="228E8737AC15FF43" modified="2014-10-29" version="1">MPKLHVGRQAADDNNKFEIDVASLTKHAIILGATGSGKTVLSKVLVEEAALQGIPTFAIDPKGDIGNLAFKSANFDFSRWSEKEADALKTDRVEYAKSLQKAYADRMAEFAVRQDAQAEFAKTVTVRIFTPKSSAGLPVGISPDLSAPKDFSKLLENDVSATADLLDLTSYNLLRLAGYGEGDRKEITFVSALLEDAWKSGQSVTVKDLIRKIESPPISTVGSLHVSDVLGDKDRRKLVTRINLLVSDPKLRSWSAAESLDFSELMKGPSINVLDLRNIQSEQEKHLFVELVLQRLFQWLIKQGSAQTLRYLLYFDEIAGYCPPVREPPSKKLLLLLIKQARAFGLGLLLASQNAVDLDYKVISNANVRFIGRLGAQRDIQRVSVGLELDSFAEKEISRLKAGEFFCNMFDPKFRGVIKSRWTLTYHRGPLENGEIAELMEGMKEKEKEKSQPSAAEQQEKITTTVALEEEKSAEEEEEKLLPKPEEKEIHHDPLVAAAGGAHATTFVQLERKFEPKNLQSFAKLGNNVSSIKVLSTEQEEVFHPVFELSASVFEKGYARQSLDKLEELAAFESQLVPLPAAHTLAPQRAVPAEARRKAEEKWNGELEKRTATLKADLQAKFDVIMEEKRVEHIAEKQARPKAKIANIDASIARLQEALNAELDSIKDQERLYKQLKKEKAKKSRLISAENRIETKKQKAVATRRKIEQLHTDRQALEDKLAEIEEEENEKFHDALSQVKSKSGFAVTGWLIETVYRARITVNDNKEHAGDVRWSSYTGRGTWGRCSVCSVPLESGSACNCGNLMCNHHLAYCKACLEPACMDHRALCYICNSTFCARHSAKCELCSLSACTSHSGACSVCNRKVCSNCSQKRGLIKREIVCRSCLSSSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MZT9</accession>
    <name>A0A075MZT9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02707</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701265.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MZT9"/>
    <dbReference type="STRING" id="1459636.NTE_02707"/>
    <dbReference type="GeneID" id="41598396"/>
    <dbReference type="KEGG" id="nev:NTE_02707"/>
    <dbReference type="HOGENOM" id="CLU_156997_0_0_2"/>
    <dbReference type="OrthoDB" id="5745at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="109" mass="12744" checksum="A236E80B6139B7E3" modified="2014-10-29" version="1">MKANNYAMKDWHLEHVEKVIVRYVKGVSPDASSFEKRNYKKYSTVSSCAKQIEYDIKHGVTHEEVMAVVRKVRHDKSFKDLQKNPESLQRLDELERQICAPKKVAASFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N0G8</accession>
    <name>A0A075N0G8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02943</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N0G8"/>
    <dbReference type="KEGG" id="nev:NTE_02943"/>
    <dbReference type="HOGENOM" id="CLU_1536712_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="174" mass="19172" checksum="3EB3F12CE431EBD3" modified="2014-10-29" version="1">MGCSKLLIRQYISYLADNARKYRTFNKQLVVGELAGIAAGLLVAELAIAIALDEAGVSIASSAADYLAALAGFLAIFYFDSRKEFMQFGRGKRVQKVCVMALRLWPSVAAADIVFIFVRPYVQYLLLGANIEAGVTSVIAHFVAFAAFNLTAIFSRSIMDFWQSTKKQRQQQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N1I5</accession>
    <name>A0A075N1I5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Polyketide cyclase / dehydrase and lipid transport</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701754.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N1I5"/>
    <dbReference type="GeneID" id="41598954"/>
    <dbReference type="KEGG" id="nev:NTE_03300"/>
    <dbReference type="HOGENOM" id="CLU_1667531_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="130" mass="14861" checksum="51DE575D57E2E966" modified="2014-10-29" version="1">MPDAAPWCFKIGVPTPKECRIVGEAKGVGSHRQCRTGKGFIDQQITEWNPPYRLAFVATSDTIGMYKHIKQMQDTFLLEAVEDSTRLTRLTQFETKGAFDFVKAFLFKLAVRRLHKYVMEGFKTLAEAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLD0</accession>
    <name>A0A075MLD0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rad51</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_00004</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLD0"/>
    <dbReference type="STRING" id="1459636.NTE_00004"/>
    <dbReference type="KEGG" id="nev:NTE_00004"/>
    <dbReference type="eggNOG" id="arCOG00415">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1154378_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000730">
        <property type="term" value="P:DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042148">
        <property type="term" value="P:DNA strand invasion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942:SF66">
        <property type="entry name" value="RE19845P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942">
        <property type="entry name" value="RECA/RAD51/RADA DNA STRAND-PAIRING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad51-like C-terminal" evidence="2">
        <location>
            <begin position="97"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF82088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="283" mass="31762" checksum="E1E1764BA71D9B3C" modified="2014-10-29" version="1">MLNRNQTLQYFCSKCNSLLRCTTANVDPSKIIEPCPNCGNSLAESLEIRRPKQKDDEVLLPEFQIAQAVPALTFDLKQIDAFFLGSRIGDILCIVGSRETLLASRLSVRALLPKRLGGLESHVLFIDGGNNSDIYQCVNFARQYGLDIKKVLEGIVVSRTFTIHQLAWLVIHELPKAIERFGSKLVIISGILTLFTQDPQVDQKEARRLLREMMIAIKRISGKALVVITADSIHGYEDIFAKLKNRIKIQNAESGIIKLFASTPYRSKEIVLPEKSLKLVKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLG3</accession>
    <name>A0A075MLG3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00204</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLG3"/>
    <dbReference type="STRING" id="1459636.NTE_00204"/>
    <dbReference type="KEGG" id="nev:NTE_00204"/>
    <dbReference type="HOGENOM" id="CLU_3075135_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="52" mass="5826" checksum="2F86903F5F0BD947" modified="2014-10-29" version="1">MQQQLLFFSQKGMTKTTSTEAITRRSVITIVVVVAAAKLFFRIHGAEKKEQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLQ3</accession>
    <name>A0A075MLQ3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699249.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLQ3"/>
    <dbReference type="STRING" id="1459636.NTE_00126"/>
    <dbReference type="GeneID" id="41596066"/>
    <dbReference type="KEGG" id="nev:NTE_00126"/>
    <dbReference type="HOGENOM" id="CLU_2839204_0_0_2"/>
    <dbReference type="OrthoDB" id="375948at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="65" mass="6773" checksum="5FB88D4E8E131862" modified="2014-10-29" version="1">MGLLTWIVIAVVIVLIIGIGVEAFFSGLISGAEKLGNNPVIKNATEEGKNFAKDAIQNATSGMVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MM77</accession>
    <name>A0A075MM77_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00281</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MM77"/>
    <dbReference type="KEGG" id="nev:NTE_00281"/>
    <dbReference type="HOGENOM" id="CLU_473814_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="538"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="301"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="363"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="558"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="575" mass="63763" checksum="0A82D92301F4A82D" modified="2014-10-29" version="1">MRVWQCGICGYWSERIRNVERHNKSIHAGAAVVLPAYATLVIEPSYRITLLGSPPLAAHDTRMVPATLDGERASAAKKPFSLAEHMNSQFEKHIKPIEEFQKTLNRIQRLRGIEGFSASIPIQPAAFPIHYSPVKTVGIEGTICDKCFTIVLTHIPHSPRPEEFQLPIESSHGCKGEREFPSKIAREDEKLLVQEKMVNKLFEEVKMWLKDKEIVLEVEKLEDDYTPHSSASVITYKPESADLDLLAREACTMPINDEELKSFLKDAHSTIGIYKEVAKDSEINHYYRLSIQGKAREEPPTTGDAATGAGNNTTTTNATAAIASASNGTPENKWEEHKKATTATLKEKQQEATDDPSSGGGSSKTSNETTKTAAEATTSPKFGGIDLVVCNECCNPYVIPIFIPRNPELEKLFHYQCPGKAMFESEEARLERVRKSEADGVQLLFEAARICMPEGKIALAVTKIEPRNPSLAKYAIQHDGKDPGHYLSRAAKDGIASLDENELRDFLAHNKSTYGYYEIPSNGEQYFAAIIQNQTKEANATKSLPGDREVTTTSTTKEANRVPNKDMKSEQGELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MM87</accession>
    <name>A0A075MM87_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00291</name>
        <name evidence="2" type="ORF">NTE_01137</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MM87"/>
    <dbReference type="STRING" id="1459636.NTE_00291"/>
    <dbReference type="KEGG" id="nev:NTE_00291"/>
    <dbReference type="KEGG" id="nev:NTE_01137"/>
    <dbReference type="HOGENOM" id="CLU_971826_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="286" mass="32945" checksum="D9199EC19BA42103" modified="2014-10-29" version="1">MPVNTEIPERLWLPLLILDKSDGVIHGKTKFQKLTFLTQVLAHIDEYDFRKYHYGPFSDLLELDLSAYSGLVTIVENESMMNYGQHYFSFYLTSNGKKEIEKMKKELLPRTLEKVENIIESRLARTRCELLDEVYSKFGIDPKDSLKLAAEVKKELENILPPLIECSRTYNNRQSAFVLSTLEIIGNILKALESVSDTAKRGVALYLSRELIHKIADTSKDVRPPANSELLRPRFLEIAELESYLLGYCDKRKIYNNPFERTLDEAFTEEEAKRLAQSLSNLNLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MM91</accession>
    <name>A0A075MM91_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Erythromycin esterase-like enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00143</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987091.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MM91"/>
    <dbReference type="STRING" id="1459636.NTE_00143"/>
    <dbReference type="GeneID" id="41596082"/>
    <dbReference type="KEGG" id="nev:NTE_00143"/>
    <dbReference type="eggNOG" id="arCOG08208">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026490_1_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14728">
        <property type="entry name" value="Ere-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1660.10">
        <property type="entry name" value="EreA-like (biosynthetic domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1870.10">
        <property type="entry name" value="EreA-like, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007815">
        <property type="entry name" value="Emycin_Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052036">
        <property type="entry name" value="Hydrolase/PRTase-associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014622">
        <property type="entry name" value="UCP036794_erythomycin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31299">
        <property type="entry name" value="ESTERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31299:SF0">
        <property type="entry name" value="ESTERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05139">
        <property type="entry name" value="Erythro_esteras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036794">
        <property type="entry name" value="UCP_erythr_ester"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159501">
        <property type="entry name" value="EreA/ChaN-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="499" mass="57905" checksum="CF72FC9BBB00E7AB" modified="2014-10-29" version="1">MMTVYKLENASNLDPLLEHIGDARYVLLGEASHGTSEFYAWRTEITKRLIAEKDFSFVAVEGDWPDCYRVNRYVKGMAEAGSSAFEVLHAFSRWPTWMWANREIIELVGWLRFYNDRRVAGRNNRERRRDRKATTTTAAGFYGLDVYSLWESLDAVMQYLKKNYPDSLKAAINAYSCFEPYGRDVEEYARATAFIPESCEDEVVEMLVELRQKEQRKERNLASGGYKSDEEEKEAYFDAEQNAVVAKNAELYYRTMMKGSAASWNVRDHHMMNTLERLMRFHGSDSKCIVWAHNTHVGDARATDMQRAKMVNLGQLAREQAGHDNVVLVGFGTYEGTVIAAKEWGEKMEKMPVPPAIDGSWDSFLHKYDEAAERYDDDGSDSRSNNDNDNRKTIKDKLFIFSNRGKEGYSTFLVPRGQRAIGVVYNPSYERYGNYVETILPERYDALLFILIKQMRSDQYTCQYRQTRNFQRLFLLVHDDISTHACVCMRACMCYCYYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMD9</accession>
    <name>A0A075MMD9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMD9"/>
    <dbReference type="KEGG" id="nev:NTE_00560"/>
    <dbReference type="eggNOG" id="arCOG08684">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128582_1_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="147"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="179" mass="20703" checksum="D614824F57B1CE2D" modified="2014-10-29" version="1">MVVDYQFLNSLCEQILARANSIRWTAIASDNGVILSSKQRPGLLPLLTQEENEEYVLSAISRHKTRTKFETKIGKLRYAFGKYEGLNRATIPITKHHYLLLTIDKEEKNFDSIITEKILPLIDNNINRFTDSPMEKDPASEYELGTFRCITCAKEFLTKEDADEHHYETHKQESIHANE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMH5</accession>
    <name>A0A075MMH5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699594.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMH5"/>
    <dbReference type="STRING" id="1459636.NTE_00590"/>
    <dbReference type="GeneID" id="41596453"/>
    <dbReference type="KEGG" id="nev:NTE_00590"/>
    <dbReference type="HOGENOM" id="CLU_992469_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="280" mass="31708" checksum="F1CA9FA04E0F7CEF" modified="2014-10-29" version="1">MPWNGDGKKSVIGKDEEKKKRRAAAIIVAVLFLAVPLVFPATTLPILLPSYAATPDSKENLSNELFVKYEQLAWHYSYQESETQNLESFKEWWCQDPADDSCALAKNPDFIFMMRYFEQNRDAVIWNLTQQAPQVNVLPRHIKYLVSRDYADATNVEGTFAAPWKSFVTWNQLAFHFDFAKNETQNLQAFEKWWCEGPATGSSGNVACNSNAAASGQLVPMMWFNEQHRDNILAAKVIKQLDALANKSKIAGWISMDYQCAIEKNANACDMMTAADDKVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMQ0</accession>
    <name>A0A075MMQ0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00466</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699498.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMQ0"/>
    <dbReference type="STRING" id="1459636.NTE_00466"/>
    <dbReference type="GeneID" id="41596341"/>
    <dbReference type="KEGG" id="nev:NTE_00466"/>
    <dbReference type="HOGENOM" id="CLU_2406204_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="92" mass="10865" checksum="3BAB528AD6BA6436" modified="2014-10-29" version="1">MAELITDAEKEKIWLVYIQAWNNPTFRKEFVENPAQAIDRHQDKFGFNYTNLSEHAKKVVSAATMEELEAVAKFREKMRSVHCWIPEPVSYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMS8</accession>
    <name>A0A075MMS8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00063</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699206.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMS8"/>
    <dbReference type="STRING" id="1459636.NTE_00063"/>
    <dbReference type="GeneID" id="41596014"/>
    <dbReference type="KEGG" id="nev:NTE_00063"/>
    <dbReference type="HOGENOM" id="CLU_2366315_0_0_2"/>
    <dbReference type="OrthoDB" id="9004at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="100" mass="11380" checksum="101DA586DECDCCF9" modified="2014-10-29" version="1">MSESRYPVSATFKVLDGYDLYRSDNLIVALVVVESQYGRDLRLYRWMKRKEQWKVDLCRMSVKRWKWAEVAAKASEFIEKYNVKGGGGGGAAAGPEPEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMU5</accession>
    <name>A0A075MMU5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YVTN family beta-propeller repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMU5"/>
    <dbReference type="STRING" id="1459636.NTE_00676"/>
    <dbReference type="KEGG" id="nev:NTE_00676"/>
    <dbReference type="eggNOG" id="arCOG02562">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009318_2_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051200">
        <property type="entry name" value="Host-pathogen_enzymatic-act"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011964">
        <property type="entry name" value="YVTN_b-propeller_repeat"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02276">
        <property type="entry name" value="beta_rpt_yvtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47197:SF3">
        <property type="entry name" value="DIHYDRO-HEME D1 DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47197">
        <property type="entry name" value="PROTEIN NIRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="426"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="453" mass="47906" checksum="C6E9E88814586581" modified="2014-10-29" version="1">MLQNKMRCAFCILLLKGGSNSSGQQTLTSRPLHSCLDRTKTLFLLSATILMTSVIAVAPLHLQQQLAFASSSDAAATDSDNNSTFVGSNSQIIAATTSVRPESIAVNPNTGIVYVANWIDYLANTTGAFGASGSISVINGSSTELMSYIALDGAPLKMAVNPNTGMVYVTESRNNLVAVIDGTANKVIDTIRVGNRPAGVAVNPNTNMVYVANWNYPDGFVSVINGSTNSIVANVTLGTGASYGIAVNPNTNKVYVDSFAYSRNGSNIVSVIDGSTNKVVANVTVGALNYVVRTGVSTFPDAFRYGVDIAVNPKTNMIYTDNNYVSVIDGAVNKVVANVTLDSLPLRAISVNPETNLVYVPNSEGNIQVIDGSTNEVMGMMKLGGVISDVVFNPNTDKLFVASETSVNKASVIITDDSNIQRVPEFPAYFLTIISLAIPLAISVGYARYRKLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMY4</accession>
    <name>A0A075MMY4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Iron-binding zinc finger CDGSH type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NTE_00743</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699716.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMY4"/>
    <dbReference type="STRING" id="1459636.NTE_00743"/>
    <dbReference type="GeneID" id="41596595"/>
    <dbReference type="KEGG" id="nev:NTE_00743"/>
    <dbReference type="eggNOG" id="arCOG03174">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1233392_0_0_2"/>
    <dbReference type="OrthoDB" id="5781at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.90">
        <property type="entry name" value="CDGSH iron-sulfur domain, mitoNEET-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052950">
        <property type="entry name" value="CISD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010693">
        <property type="entry name" value="Divergent_4Fe-4S_mono-cluster"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018967">
        <property type="entry name" value="FeS-contain_CDGSH-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042216">
        <property type="entry name" value="MitoNEET_CISD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016548">
        <property type="entry name" value="UCP009180"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46491">
        <property type="entry name" value="CDGSH IRON SULFUR DOMAIN PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46491:SF3">
        <property type="entry name" value="CDGSH IRON-SULFUR DOMAIN-CONTAINING PROTEIN 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06902">
        <property type="entry name" value="Fer4_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09360">
        <property type="entry name" value="zf-CDGSH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009180">
        <property type="entry name" value="UCP009180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00704">
        <property type="entry name" value="ZnF_CDGSH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iron-binding zinc finger CDGSH type" evidence="5">
        <location>
            <begin position="47"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Iron-binding zinc finger CDGSH type" evidence="5">
        <location>
            <begin position="197"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF82821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="238" mass="26502" checksum="92804AFACEE33144" modified="2014-10-29" version="1">MRKEDQNVDKSLEKKIIVSKNGPYLVSGGIPLSMQIITPNKEGFSWDWTEGRSFDTQSEYALCRCGQSKNKPFCDGTHEKIGFEGKETATRRPYVRQAKKYDGPTMVLSDAENLCAFARFCDPAGQIWNLIEQTDNSAARDLVIREANHCPAGRLVVHDKKTGKEIEHKLPPSIGVVEDPALECSGPLWIRGGIPIESHDGKRYEVRNRATLCRCGASSNMPFCNGSHASIKFRDGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MN73</accession>
    <name>A0A075MN73_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transposase, IS605 OrfB family, central region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NTE_00623</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the transposase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MN73"/>
    <dbReference type="STRING" id="1459636.NTE_00623"/>
    <dbReference type="KEGG" id="nev:NTE_00623"/>
    <dbReference type="eggNOG" id="arCOG00684">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032903_0_1_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Cas12f1-like_TNB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051399">
        <property type="entry name" value="RNA-guided_DNA_endo/Transpos"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040570">
        <property type="entry name" value="guided_TnpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01766">
        <property type="entry name" value="IS200/IS605 family accessory protein TnpB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30405:SF25">
        <property type="entry name" value="RNA-GUIDED DNA ENDONUCLEASE INSQ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30405">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="Cas12f1-like_TNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Probable transposase IS891/IS1136/IS1341" evidence="7">
        <location>
            <begin position="130"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Cas12f1-like TNB" evidence="8">
        <location>
            <begin position="242"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF82703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="360" mass="41620" checksum="9807177DB1B205B6" modified="2014-10-29" version="1">MSEYDMNYALTELKEQHPWLRNYYAKMLQMVAKQVAAARKATSSLKRNGCKTGRLSYRYNDDFHAFAYNQKGFKIEENRLVLAKIGRIKIILHRKPINIKQVTICRKNGKWYAVVGCEILRRSCSTIVYKKPVGIDVGITKFAHDSDNHVVENPQFSTRMSRPLKRAHRRLSRKKLGSNNRKKARRMLARLYERINNKRSDFLHKTSAYYCRNYDLIFLERLRMANLTKNHKLAHKILDASWYTFKIMCQYKANRVVEVDPAYSSLDCSRCGHRVPKSLAVRIHSCPKCGALLDRDYNSAINHLQNGLTLLQLPVERREVTPVEPQSKVIETGTLYGDMQLTRGTGASLSGKPVPSPRAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MN83</accession>
    <name>A0A075MN83_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2-nitropropane dioxygenase-like enzyme</fullName>
            <ecNumber evidence="4">1.13.12.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_00534</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.13.12.16" evidence="4"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699552.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MN83"/>
    <dbReference type="STRING" id="1459636.NTE_00534"/>
    <dbReference type="GeneID" id="41596406"/>
    <dbReference type="KEGG" id="nev:NTE_00534"/>
    <dbReference type="eggNOG" id="arCOG00635">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038732_1_1_2"/>
    <dbReference type="OrthoDB" id="304666at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332:SF20">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF82615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="328" mass="35033" checksum="D6962A78C5731D9B" modified="2014-10-29" version="1">MIRTPLCDVLNIQYPIIQAAIAPYTTAELVSAVSNAGGMGSIGSALRSMDDLRMQVARTKELTSRPFAINFTITTFNEDIFNYVVSEAKPRIVSSALGNPKELVKRVHDAGLLFMHQVHTVKQARQAAELGVDVIIAQGSEAGGFTGNVSSLSLVPQVVDAVADKKIPVIAAGGIADGRGLAAALMLGAQGVNMGTRFLASSEASLVGPEWQKQIISAESEDAIKVNFLDSVFPVANPDAYGEIAPRALRTRFIEEWNIKSGEAKSQAPQLRSTILTGIKEGRSHELVPFSGQSAGLIRNVLPAKEIITNIMNEAEERIRSLKANALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNC9</accession>
    <name>A0A075MNC9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Trk-type K+ transport system, membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">NTE_00230</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TrkH potassium transport family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699323.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNC9"/>
    <dbReference type="STRING" id="1459636.NTE_00230"/>
    <dbReference type="GeneID" id="41596149"/>
    <dbReference type="KEGG" id="nev:NTE_00230"/>
    <dbReference type="eggNOG" id="arCOG00606">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG04145">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_451740_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32024">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN TRKG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32024:SF2">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN TRKG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="153"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="418"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="508"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="619"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="680"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="12">
        <location>
            <begin position="14"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="12">
        <location>
            <begin position="79"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="544"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="546"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIF82312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="706" mass="76445" checksum="0F2D1631D4669EE5" modified="2014-10-29" version="1">MQNDVLERPITSYMNRLYVVLDENTNVASAVRQMNSQNAETIIVSKNGRPAGIVTDSDILDQVVMKGEDSDQVFLKAIMSKPLVTISPRGTIRQALQLMRINQVKRLPVVADGSEVLGIVTQVALANAVRTSVLEKTFSHYRSGMFTEKYKPILGNLGILLQFSGVLLVVPAFIGAALGESTSATGILFAVIGLSFAGFFLTHIGEKGPMNLKQASIFIVSGFLLLSLFGSIPYIYLDPFRPSDEMSLSSLFVNSFFESASGFTTTGLSIISNPQDLPKSLDFYHSYTQWVGGLSFMYLVMIIFFPERKLNAMKSVLGGGMLRVKELLITIVVIFTAYTIILVLAMVFVGQTDVLNATALVFSSITGGGFLPDTDLISPLHPERMTFVAVGMILSALPFAFHYYIFAAKSGLRERRTISLEVAVFFLVMAASIPIFYVLAGGLDNTIDPAGVATATAEGSDSSNRRSSSGDVVVDIYSAAFHVLSSATTTGFQYLNIQSLSPVAKMSLILLMLVGGTAFSTAGGIKIGRFVILYQELAKKAKEKTTTTASSPSPPIATGSTSTSTSISSTANPYRSSEFFEGLQEHNQKKQIDAEEEKIDRQKATHFVKRVKVTTSKKIVREILLVISLYISISVATGYIISVVTGSSLEDALFESVSAISTAGLTAGITSVDLDPFSKLILAANMIVGRFEIIAILYIFFSYFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNH5</accession>
    <name>A0A075MNH5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative unusual protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_01032</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNH5"/>
    <dbReference type="STRING" id="1459636.NTE_01032"/>
    <dbReference type="KEGG" id="nev:NTE_01032"/>
    <dbReference type="eggNOG" id="arCOG01189">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006533_0_3_2"/>
    <dbReference type="OrthoDB" id="8087at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05121">
        <property type="entry name" value="ABC1_ADCK3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050154">
        <property type="entry name" value="UbiB_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10566">
        <property type="entry name" value="CHAPERONE-ACTIVITY OF BC1 COMPLEX CABC1 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10566:SF113">
        <property type="entry name" value="PROTEIN ACTIVITY OF BC1 COMPLEX KINASE 7, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="526"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="120"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF83106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="549" mass="61477" checksum="520ABCC8D766EDBA" modified="2014-10-29" version="1">MAGQGREIAAAPSSSSSSVQDVVPVYSRPSRLRVVRVILKLLPVALALRRDRREWVRKEGKGVDEAKYRRHAEKALSTFISLGPSYIKLGQWLSSRADILPQPYLEVLARLQDDVPPAPFSEIKPIIEGELGRIEDVFEEFDSIAKSGASLGQVYLAKHHGGQVIVKVGRPNIERIIADDVYVLQKILPLATRFIDPNLRFSAEGMLAQFIETIHEEMDYRIEAENLATIKRNLAGDSMVRIPDVFLDRTSRHVLTMEYVPGIKITDIAALDARGIDRAKLVINIHHLFFKMLLRHSVFHADPHPGNISVEDSDKARLILYDFGMVGRLDNETRLRLIRLYLGLLDKDPERTVNVLIELGTLEPTVNRYIVEKGIALSIQTMYGRQVDKMEVKALMDLANKTMSRFPFRLPKNLALYMRMASILEGIYQHHKVKFQFVKVLGNLLEEEGLVRDAYIEEVKVSARRIAKGIEASATVGPLLKSYLENQPMFGTEKRQQSSSPMLPASILASALFVGSAFMLAQNPAFSYAGFAAAAAAIIVGTIKGKRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNJ4</accession>
    <name>A0A075MNJ4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00693</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699676.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNJ4"/>
    <dbReference type="GeneID" id="41596549"/>
    <dbReference type="KEGG" id="nev:NTE_00693"/>
    <dbReference type="HOGENOM" id="CLU_084395_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043200">
        <property type="term" value="P:response to amino acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30154">
        <property type="entry name" value="LEUCINE-RESPONSIVE REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30154:SF34">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR AZLB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13412">
        <property type="entry name" value="HTH_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="227" mass="25169" checksum="630F6C941E4FA267" modified="2014-10-29" version="1">MSDAESAAVVEYKAQTYNSSRQALEEELSKLEINPEFFKTLTVDQLADLLFGLNRAMNANAGSAAANKIAKKVSSGLSSIDKKILKALLESNGSPSSLQLSRELDIPITTVQRRRKRLEDEFVNEFYSLQYEKFGKRQVTFIVSLGAVDKNAIANEILGLEKVIAVARTFGDGADLKIEAILESNQEFMETSEKIKAIQGIQKVCWFESLEILGRKKELDQAIVESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNL3</accession>
    <name>A0A075MNL3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00718</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385047.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNL3"/>
    <dbReference type="STRING" id="1459636.NTE_00718"/>
    <dbReference type="GeneID" id="41596570"/>
    <dbReference type="KEGG" id="nev:NTE_00718"/>
    <dbReference type="HOGENOM" id="CLU_124803_5_2_2"/>
    <dbReference type="OrthoDB" id="7611at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="120" mass="13886" checksum="F7BF32CAD9929C22" modified="2014-10-29" version="1">MRAIERESLKQAIMVAMADKEMVRILDSCTLRSKSVSDVIRETGISHSTAYRKIKWMLEEGLLFTEKIEITPDGKKFSLFRSTIKSINAKYEHGKLDVEIEYNINRLERTAERLFSLEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNN0</accession>
    <name>A0A075MNN0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01088</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699979.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNN0"/>
    <dbReference type="STRING" id="1459636.NTE_01088"/>
    <dbReference type="GeneID" id="41596904"/>
    <dbReference type="KEGG" id="nev:NTE_01088"/>
    <dbReference type="eggNOG" id="arCOG08763">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2257459_0_0_2"/>
    <dbReference type="OrthoDB" id="6477at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="100" mass="11855" checksum="CBE446BD40B78A54" modified="2014-10-29" version="1">MADFFEIDRLIDELARLYATACATAWFKIEKKKPAQDEYRAKVVEFMRHFEYTLSTFQKTPEADSFRAHAKKALEAEIEKVLAGQNKEVEKRYKYFVDYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNN1</accession>
    <name>A0A075MNN1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_00740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699714.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNN1"/>
    <dbReference type="STRING" id="1459636.NTE_00740"/>
    <dbReference type="GeneID" id="41596592"/>
    <dbReference type="KEGG" id="nev:NTE_00740"/>
    <dbReference type="eggNOG" id="arCOG01792">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1028971_0_0_2"/>
    <dbReference type="OrthoDB" id="10070at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050447">
        <property type="entry name" value="Erg6_SMT_methyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068:SF11">
        <property type="entry name" value="GERANYL DIPHOSPHATE 2-C-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068">
        <property type="entry name" value="ZGC:194242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="2">
        <location>
            <begin position="48"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF82818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="260" mass="28645" checksum="88333156A99F3963" modified="2014-10-29" version="1">MTIAAGGRMLNFGYWDDSSSAKTPLEAQQMLCAAVGELAELASSMTVLDVGSGLGAPAAYWKSCYKSLQVACVNINFSQLQNSKDAQASLVNATSTALPFASNSVDRVIALESAQHFRPLGRFVQESARVLDSGGLLVMAIPVLKLRKKRLLHFLSLGILAVTWSSEHYDPEYVERAITGAGLSIESSRYIGKNVYGPLADYYLKNRENLRPRILAAYPAYLEKILYRSILKMKQLSDKGDIEYVLLKARKTDTLTREKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNR0</accession>
    <name>A0A075MNR0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Translation initiation factor 5A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Hypusine-containing protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 11">eIF-5A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">eif5a</name>
        <name evidence="13" type="ORF">NTE_00770</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Functions by promoting the formation of the first peptide bond.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the eIF-5A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_193354097.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNR0"/>
    <dbReference type="STRING" id="1459636.NTE_00770"/>
    <dbReference type="GeneID" id="41596621"/>
    <dbReference type="KEGG" id="nev:NTE_00770"/>
    <dbReference type="eggNOG" id="arCOG04277">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102600_3_0_2"/>
    <dbReference type="OrthoDB" id="23689at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045901">
        <property type="term" value="P:positive regulation of translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045905">
        <property type="term" value="P:positive regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04467">
        <property type="entry name" value="S1_aIF5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00085">
        <property type="entry name" value="eIF_5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001884">
        <property type="entry name" value="IF5A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048670">
        <property type="entry name" value="IF5A-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020189">
        <property type="entry name" value="IF5A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019769">
        <property type="entry name" value="Trans_elong_IF5A_hypusine_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022847">
        <property type="entry name" value="Transl_elong_IF5A_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00037">
        <property type="entry name" value="eIF_5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003076">
        <property type="entry name" value="PRK03999.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11673">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 5A FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01287">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21485">
        <property type="entry name" value="IF5A-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003025">
        <property type="entry name" value="eIF5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01376">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00302">
        <property type="entry name" value="IF5A_HYPUSINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11" id="KW-0385">Hypusine</keyword>
    <keyword evidence="6 11 13" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translation initiation factor 5A C-terminal" evidence="12">
        <location>
            <begin position="64"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="modified residue" description="Hypusine" evidence="11">
        <location>
            <position position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIF82848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="129" mass="14413" checksum="0C49D8EAF69C5C34" modified="2014-10-29" version="1">MELGALKIGSYIIIDGEPCRIVSYDHSKPGKHGSAKARINAVGVFDGNTHPFVGPVTTRVEVPLIDKRNGQIISKNGDTLQIMDLETFEVFETSSVEDEIKDKLQDNVNGREVEYWKVMDRIKIVRVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNS2</accession>
    <name>A0A075MNS2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699683.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNS2"/>
    <dbReference type="GeneID" id="41596556"/>
    <dbReference type="KEGG" id="nev:NTE_00700"/>
    <dbReference type="HOGENOM" id="CLU_2067695_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="118" mass="13541" checksum="6C0085D9665A6F67" modified="2014-10-29" version="1">MRYFAYAVMRLKILSAFLCVGWITNDLPLLIAYDDPIVLLPLVINAFWALLPWGVGTVVSFTANSLFVELRCSHCKDSFRRHEKPSGEVHACKGWHFDIRHFRLTRWGCPAFIASKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNT1</accession>
    <name>A0A075MNT1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative stress protein (General stress protein 26)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_01128</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNT1"/>
    <dbReference type="STRING" id="1459636.NTE_01128"/>
    <dbReference type="KEGG" id="nev:NTE_01128"/>
    <dbReference type="eggNOG" id="arCOG00516">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140794_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070967">
        <property type="term" value="F:coenzyme F420 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052019">
        <property type="entry name" value="F420H2_bilvrd_red/Heme_oxyg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35176">
        <property type="entry name" value="HEME OXYGENASE HI_0854-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35176:SF6">
        <property type="entry name" value="HEME OXYGENASE HI_0854-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="PNPOx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine 5'-phosphate oxidase N-terminal" evidence="2">
        <location>
            <begin position="29"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF83201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="170" mass="19610" checksum="4A221F99B115A5D1" modified="2014-10-29" version="1">MFISKLDPNVRTHMKLIQAMPDMPSPVTEAEVERFLESKLNIQLATIDEEGYPNIQPIWFYYDKESGKIYTGTQKTTKKIQNIRRNPGKIYFSIDDENFPYKGVKGRGEASISEDRQKNLAIVEKINLKYLGTLEHPLAKMLMDNTRNGTELVIQITPKFFSAWDFGKAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MP09</accession>
    <name>A0A075MP09_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00817</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
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    <dbReference type="STRING" id="1459636.NTE_00817"/>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="56" mass="6365" checksum="17587DCE6D7668C1" modified="2014-10-29" version="1">MECLGDNDVRWELHVIKMLDVLNVAASSASQRCLKTQMSDIVQLIICSKYCVLKNH</sequence>
</entry>
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    <accession>A0A075MP23</accession>
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    </organism>
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        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
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    </reference>
    <dbReference type="EMBL" id="CP007174">
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    <dbReference type="KEGG" id="nev:NTE_00887"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="136" mass="14804" checksum="F13979BC0680B76C" modified="2014-10-29" version="1">MLAFMLIANAVNGLVLWNFFPLHMRGAEMTFTDTMHVILAAMGGIFGSLAIGFGAVTFGKRFLFYSVAAVVMLFAPTILAFSFVPQVAANFSVVRALGAYRICGLYAMADSTICRSFAREEWSSTTSYRGTSKEAQ</sequence>
</entry>
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    <accession>A0A075MP70</accession>
    <name>A0A075MP70_9ARCH</name>
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        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">NTE_01267</name>
    </gene>
    <organism evidence="1 2">
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        </lineage>
    </organism>
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        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700123.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MP70"/>
    <dbReference type="GeneID" id="41597072"/>
    <dbReference type="KEGG" id="nev:NTE_01267"/>
    <dbReference type="HOGENOM" id="CLU_200166_0_0_2"/>
    <dbReference type="OrthoDB" id="9048at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
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    </dbReference>
    <proteinExistence type="predicted"/>
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            <dbReference type="EMBL" id="AIF83336.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="61" mass="6735" checksum="C02D57666231F239" modified="2014-10-29" version="1">MVVATRPFATRPVQLALRKKVAFCIECDKAVATTEALFKVEGAIIVRKYCDACIKDAVYKA</sequence>
</entry>
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    <accession>A0A075MP93</accession>
    <name>A0A075MP93_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00953</name>
    </gene>
    <organism evidence="1 2">
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="KEGG" id="nev:NTE_00953"/>
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    <dbReference type="Proteomes" id="UP000028194">
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="37" mass="4183" checksum="EE67D9EE2D5BA8A0" modified="2014-10-29" version="1">MSKAIFLKFSPPTTFVVNFAKVYKTKVDDFITVPSKS</sequence>
</entry>
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    <accession>A0A075MP96</accession>
    <name>A0A075MP96_9ARCH</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">NTE_00904</name>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MP96"/>
    <dbReference type="KEGG" id="nev:NTE_00904"/>
    <dbReference type="HOGENOM" id="CLU_2447521_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
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    </dbReference>
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    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="94" mass="10283" checksum="8FDE40E622144707" modified="2014-10-29" version="1">MLTLLTKNKKVVQNTGMFFLVLGTSIHAFNVANLMTPGLSHTWSAIAIMGFVPTAGSQVGGKIRKQAANVRRRKRLYSKLSMLGSEDRNVVPLP</sequence>
</entry>
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    <accession>A0A075MPD6</accession>
    <name>A0A075MPD6_9ARCH</name>
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        <submittedName>
            <fullName evidence="2">Peptidase propeptide domain-containing protein</fullName>
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        <name evidence="2" type="ORF">NTE_01004</name>
    </gene>
    <organism evidence="2 3">
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">SR1</strain>
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    </reference>
    <dbReference type="EMBL" id="CP007174">
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    <dbReference type="STRING" id="1459636.NTE_01004"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="154" mass="16764" checksum="418461A34A4627C1" modified="2014-10-29" version="1">MKFIIGLIVLPIAGMVLTLSIVAYMAASPLVEVPKPADYNSTRITTIIGETEAEKASRDALDESYQRSGYEKGAVRGGALGSTALIYVGKDGTNFAVDKDDGTLGDKMPHSLDNTQPDHYYWKVVLNFENTTKPEYDFVVDANTGRVLQRGVTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPT1</accession>
    <name>A0A075MPT1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
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    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPT1"/>
    <dbReference type="STRING" id="1459636.NTE_00779"/>
    <dbReference type="KEGG" id="nev:NTE_00779"/>
    <dbReference type="HOGENOM" id="CLU_2747965_0_0_2"/>
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        <property type="component" value="Chromosome"/>
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    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="70" mass="7396" checksum="ECAFFF73B1B83E6D" modified="2014-10-29" version="1">MCVSKKEGGGVDVILSSYHASPAFTSYVIPRVSNRIGLLVAVVIVVVIVVVVMQYAYNGVLSIFIVLAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPY3</accession>
    <name>A0A075MPY3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC-type transport system, involved in lipoprotein release, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NTE_01102</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ABC-4 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699989.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPY3"/>
    <dbReference type="STRING" id="1459636.NTE_01102"/>
    <dbReference type="GeneID" id="41596917"/>
    <dbReference type="KEGG" id="nev:NTE_01102"/>
    <dbReference type="eggNOG" id="arCOG02312">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_8_0_2"/>
    <dbReference type="OrthoDB" id="11469at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050250">
        <property type="entry name" value="Macrolide_Exporter_MacB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30572:SF4">
        <property type="entry name" value="ABC TRANSPORTER PERMEASE YTRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30572">
        <property type="entry name" value="MEMBRANE COMPONENT OF TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="330"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="MacB-like periplasmic core" evidence="9">
        <location>
            <begin position="21"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="ABC3 transporter permease C-terminal" evidence="8">
        <location>
            <begin position="288"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIF83175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="416" mass="44155" checksum="2F98C0B771674A57" modified="2014-10-29" version="1">MNIKEIFALSIDALRERKTRSALTIMMVVVGSSLMVALNGMTAGFSNFISFQFSKLAPNVLFVTSAQAQSGGDPFGGGPPPVPKITLNEAVVSRIRSLPFVSDVIPSYQGAITLEAGGRKHDTTVFSIDPQKLYVIAPTTTFFEGSSIRQNDPSAIILAERVANPPGDSTPFAVVGQTLRATYTFVDPDTGKQEKETRSFVVSGIMKATGNPTIDNAVVFNRIAGNQMLHKAGKYDALLVAADSGDFVDAVEKEIRRLYGKDIGITTPKAILETIQQFIGGFSSFTTSIALVALLVGAVGIITTLYTSVTERIREIGTMKAIGAQNSFILVLFLVEALTIGVIGATAGMGVGIMGGYVLIAGFASQDPSSQNMTPVFLPQDMGTVWGLSVGLSVLAGMYPAWRASRTAPIVALRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQ23</accession>
    <name>A0A075MQ23_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00886</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699825.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQ23"/>
    <dbReference type="GeneID" id="41596726"/>
    <dbReference type="KEGG" id="nev:NTE_00886"/>
    <dbReference type="HOGENOM" id="CLU_149772_0_0_2"/>
    <dbReference type="OrthoDB" id="12152at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="129" mass="14592" checksum="5351C49412A25419" modified="2014-10-29" version="1">MSETKLVALEDVRSQFTKLRETYEKVLPKVDPALLNDFLEREGVTSDPKSYTIEVFTREGVDVETARQYILAKTGMAPAIFDNGTHYVTNQKLTLEMLKEISDSEDVVEVRGNYCGGLGMKGAYFERRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQ85</accession>
    <name>A0A075MQ85_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Bicupin, oxalate decarboxylase family</fullName>
            <ecNumber evidence="4">4.1.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_01157</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.1.1.2" evidence="4"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700027.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQ85"/>
    <dbReference type="STRING" id="1459636.NTE_01157"/>
    <dbReference type="GeneID" id="41596969"/>
    <dbReference type="KEGG" id="nev:NTE_01157"/>
    <dbReference type="HOGENOM" id="CLU_030515_2_0_2"/>
    <dbReference type="OrthoDB" id="190812at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046564">
        <property type="term" value="F:oxalate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033609">
        <property type="term" value="P:oxalate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20305">
        <property type="entry name" value="cupin_OxDC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20304">
        <property type="entry name" value="cupin_OxDC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017774">
        <property type="entry name" value="Bicupin_oxalate_deCO2ase/Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006045">
        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051610">
        <property type="entry name" value="GPI/OXD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03404">
        <property type="entry name" value="bicupin_oxalic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35848">
        <property type="entry name" value="OXALATE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35848:SF9">
        <property type="entry name" value="SLL1358 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00190">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00835">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-1" evidence="3">
        <location>
            <begin position="60"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin type-1" evidence="3">
        <location>
            <begin position="236"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF83230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="388" mass="43820" checksum="94ABA5932DB1B981" modified="2014-10-29" version="1">MTRRLNDEDELDKVPQPIRGNEGYVDKGPRNVMLDRQNPDILSPPATDHGTLPNMKFSFSMAHQRLQEGGWTRQVTQRELPVATTIAGVDMCLKPGGIRELHWHKEAEWAYLLWGTARISGVDQNGQNFLDDVGPGDMWNFPSGIPHSIHGLQGGCEFLLLFDDGRFSEDSTFLITDWFNCTPKEVLARNFGVSESDFADLPINVDHTRYIFQGEVPGPLSSDKVKNHLGERKFSYRISDLKPVKTSGGTVRIIDSTIFPAASTIAVGIVEVEPGGMRELHWHPNTDEWQYHLEGTARMTVFAAEHNARTFDYGPGDVGAVPFAYGHYVENTSDDTLRFLEVFKSPQFQDVSLNQWMALTPPELVKQHLEVNDNFMRALRKEKRPIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQM6</accession>
    <name>A0A075MQM6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA/RNA helicase, superfamily II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NTE_01454</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQM6"/>
    <dbReference type="STRING" id="1459636.NTE_01454"/>
    <dbReference type="KEGG" id="nev:NTE_01454"/>
    <dbReference type="eggNOG" id="arCOG00874">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_558539_0_0_2"/>
    <dbReference type="OrthoDB" id="8379at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140097">
        <property type="term" value="F:catalytic activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050615">
        <property type="entry name" value="ATP-dep_DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11274:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11274">
        <property type="entry name" value="RAD25/XP-B DNA REPAIR HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="22"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="269"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="409"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="409"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF83518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="435" mass="48890" checksum="BAC16618A559D9D1" modified="2014-10-29" version="1">MPAIASLQFPFELKRDQTEAAEAWMQNGRRGSVIFSTGTGKTEIAWECARQAAIQSGKKRYAILFIVPRIVLISQNVRRLLSYGIDEGAIGTYYGERKDASREITISTYQSVINNFDLVRQADMVVLDEVHLVSETAVEFDRIFDVIVEDPGKAILGLTATIDERDPRYGTILVVAPPVKKYMIKDAVSDGRLARPVVKEVEVKFTDEEQKIYDEATGAIKEISRKLQVYDPARMTKVLMRGGARASLAKQWFAMVRKRKELLSSTKQKLYATVDIVKQHPKERIMIFSETVDSIQQLRDMLESSGIPARTIHNGVPRYEREEILGSWGKDYYPLLSVHTLEIGYDVPQVGIAIILASAANANRVAQRIGRVVRKAEGKDHALVYVVHVRDTKDKNIVKMVNAAIEKSSLSEESRSARTPRDSGKRPARGQRTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQP9</accession>
    <name>A0A075MQP9_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9 10">Prefoldin subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">GimC subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pfdB</name>
        <name evidence="13" type="ORF">NTE_01347</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 9">Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 9">Heterohexamer of two alpha and four beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700189.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQP9"/>
    <dbReference type="STRING" id="1459636.NTE_01347"/>
    <dbReference type="GeneID" id="41597145"/>
    <dbReference type="KEGG" id="nev:NTE_01347"/>
    <dbReference type="eggNOG" id="arCOG01342">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131909_1_0_2"/>
    <dbReference type="OrthoDB" id="11287at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23162">
        <property type="entry name" value="Prefoldin_beta_GimC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00307">
        <property type="entry name" value="PfdB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012713">
        <property type="entry name" value="PfdB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02338">
        <property type="entry name" value="gimC_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20903:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20903">
        <property type="entry name" value="PREFOLDIN SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="10"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="NCBIfam" id="TIGR02338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AIF83415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="133" mass="14650" checksum="4173F41FB3DD3E58" modified="2014-10-29" version="1">MSEQELPPWLREQVSRLQQLQQNLQAIMMQKQQLEVEAVETDRALEELKKAGPEDAVYKAAGSVMVKAKKDDVVKELEEKKELSATRVKVLEKQEGRVKDNLKEVESKINEMIRGGGGGPGAAGAAGPKPKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQS3</accession>
    <name>A0A075MQS3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein uS3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rps3</name>
        <name evidence="10" type="ORF">NTE_01831</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Binds the lower part of the 30S subunit head.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226986917.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQS3"/>
    <dbReference type="STRING" id="1459636.NTE_01831"/>
    <dbReference type="GeneID" id="41597595"/>
    <dbReference type="KEGG" id="nev:NTE_01831"/>
    <dbReference type="eggNOG" id="arCOG04097">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058591_1_1_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02411">
        <property type="entry name" value="KH-II_30S_S3_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.20:FF:000001">
        <property type="entry name" value="30S ribosomal protein S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.32">
        <property type="entry name" value="Ribosomal protein S3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01309_A">
        <property type="entry name" value="Ribosomal_uS3_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057258">
        <property type="entry name" value="Ribosomal_uS3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027488">
        <property type="entry name" value="Ribosomal_uS3_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001351">
        <property type="entry name" value="Ribosomal_uS3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005703">
        <property type="entry name" value="Ribosomal_uS3_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003219">
        <property type="entry name" value="PRK04191.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01008">
        <property type="entry name" value="uS3_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11760">
        <property type="entry name" value="30S/40S RIBOSOMAL PROTEIN S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11760:SF32">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00189">
        <property type="entry name" value="Ribosomal_S3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="Prokaryotic type KH domain (KH-domain type II)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="Ribosomal protein S3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="KH type-2" evidence="9">
        <location>
            <begin position="17"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="197"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIF83891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="221" mass="23916" checksum="D6703B6402F0DDCA" modified="2014-10-29" version="1">MSAVKNVMKNTYRNMEIDEFLRSELKDAGYGGVEIQKTPVGARITVFVTRPGLVIGRKGTGIKDLMAKIEQKFGFPNPQISVLEVTNPELNPNIMCNRIAQLIERGTAFRRASMWALNTIMSQGALGVEVTISGKLRTERAHFEKHTVGVVPKSGDVAGKIVQTGVSSVLTKMGLMGIQLRIASKSELPQEFQMVEGGAQATQEPAQEVTAQTGAETNGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MR51</accession>
    <name>A0A075MR51_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative phosphoribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_01512</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385221.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MR51"/>
    <dbReference type="STRING" id="1459636.NTE_01512"/>
    <dbReference type="GeneID" id="41597301"/>
    <dbReference type="KEGG" id="nev:NTE_01512"/>
    <dbReference type="eggNOG" id="arCOG00040">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1913051_0_0_2"/>
    <dbReference type="OrthoDB" id="4952at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43363">
        <property type="entry name" value="HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43363:SF1">
        <property type="entry name" value="HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="3">
        <location>
            <begin position="20"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF83575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="151" mass="17301" checksum="F1D50AE1797F3936" modified="2014-10-29" version="1">MRTYMQQTGNAAGDVEYCSWQEIQELTRKIATSLHDKAAKHDCILAIANGGIIPAKLLAEELGIDQIMLIPIRNKQIIEAEMPSLQKGKKYLVVDDIYDTGDIYQKVARVMQGFDCTFAFCMSRYHQEFGIYGKLLNHKRWIVFPWEKAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MR91</accession>
    <name>A0A075MR91_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700119.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MR91"/>
    <dbReference type="GeneID" id="41597068"/>
    <dbReference type="KEGG" id="nev:NTE_01263"/>
    <dbReference type="eggNOG" id="arCOG01055">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_159725_0_0_2"/>
    <dbReference type="OrthoDB" id="140255at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038723">
        <property type="entry name" value="ArnR1-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14947">
        <property type="entry name" value="HTH_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ArnR1-like winged helix-turn-helix" evidence="1">
        <location>
            <begin position="5"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="96" mass="11320" checksum="CAA9B06838474A45" modified="2014-10-29" version="1">MKKYRNRMDIAATILDIAQGSSGVLKTRIMYNAFLSFPQLKEYIALLTENQLLEHTPQNRNLYRTTEKGKRFLNNYREMQRMLYSAKEKAVRDAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRE8</accession>
    <name>A0A075MRE8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385340.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRE8"/>
    <dbReference type="GeneID" id="41597805"/>
    <dbReference type="KEGG" id="nev:NTE_02070"/>
    <dbReference type="eggNOG" id="arCOG01055">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_159725_0_1_2"/>
    <dbReference type="OrthoDB" id="140255at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038723">
        <property type="entry name" value="ArnR1-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14947">
        <property type="entry name" value="HTH_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ArnR1-like winged helix-turn-helix" evidence="1">
        <location>
            <begin position="2"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="100" mass="11457" checksum="882E5F9B5FF03733" modified="2014-10-29" version="1">MRGKVEITHDILQLCANEPKKRTHIMYKANLTYEQLNDYVSPLLSRGLLAKRHGHREPTDCDKVGGHAYYITTEMGRQVLQDLAKAVRHVNSLFNKPQAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRR1</accession>
    <name>A0A075MRR1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Response regulator with CheY-like receiver, AAA-type ATPase, and DNA-binding domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01443</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRR1"/>
    <dbReference type="STRING" id="1459636.NTE_01443"/>
    <dbReference type="KEGG" id="nev:NTE_01443"/>
    <dbReference type="eggNOG" id="arCOG02391">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1040581_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00156">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052048">
        <property type="entry name" value="ST_Response_Regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43228">
        <property type="entry name" value="TWO-COMPONENT RESPONSE REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43228:SF1">
        <property type="entry name" value="TWO-COMPONENT RESPONSE REGULATOR ARR22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="1">
        <location>
            <begin position="141"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="267" mass="29647" checksum="C7D5694CF0B2950C" modified="2014-10-29" version="1">MFLKSKGNSFSTPNIETDYTSRCKTILAENKQLDLVMVTDKYANIMAKAARQLPQSSIRQLSPEDIVKTALRTNIAKGAFNVNSPTTGITSNIHVQYNAMDIIMYPLENDLTLIAIGIVDPGAIADIYSSVGRHFPTKLKKAIIVDDEEDIRSSIREVLKKRGFDVETAESGPACVKAIENATSNGAEYGMAIMDIRMPGMDGFEAYKKIHPISPNTKVIFITAFEYTQEEIAKKVQNNNVKVLRKPFTRADLLQLITDETNPTPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRR7</accession>
    <name>A0A075MRR7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01797</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRR7"/>
    <dbReference type="STRING" id="1459636.NTE_01797"/>
    <dbReference type="KEGG" id="nev:NTE_01797"/>
    <dbReference type="HOGENOM" id="CLU_1465031_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="184" mass="21111" checksum="5C389F83A0196645" modified="2014-10-29" version="1">MEIEILNQIISSGYLTTGITLGVIVLFSWLLLPRFARQMRQRLTVKNDGINETLGAFAVIIRNGDILKKAKGRFTREGYLLADKRAWPMVDVRPYLLKDGWSTRPCFIVDAQKQVYYRFNNVDNEKQRQLAGFASDPELLKRFTDSTIVQKLTSAKADKTMMIMVFIMGMFAFFLIQQFLPKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRS7</accession>
    <name>A0A075MRS7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cobyrinate a,c-diamide synthase</fullName>
            <ecNumber evidence="7">6.3.5.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Cobyrinic acid a,c-diamide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">cbiA</name>
        <name evidence="10" type="ORF">NTE_01734</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>cob(II)yrinate + 2 L-glutamine + 2 ATP + 2 H2O = cob(II)yrinate a,c diamide + 2 L-glutamate + 2 ADP + 2 phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:26289"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58537"/>
            <dbReference type="ChEBI" id="CHEBI:58894"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cofactor biosynthesis; adenosylcobalamin biosynthesis; cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 10/10.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP and cobyrinate and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="7">The a and c carboxylates of cobyrinate are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the CobB/CbiA family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.11" evidence="7"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987242.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRS7"/>
    <dbReference type="STRING" id="1459636.NTE_01734"/>
    <dbReference type="GeneID" id="41597503"/>
    <dbReference type="KEGG" id="nev:NTE_01734"/>
    <dbReference type="eggNOG" id="arCOG00106">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022752_2_0_2"/>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00231"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042242">
        <property type="term" value="F:cobyrinic acid a,c-diamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05388">
        <property type="entry name" value="CobB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03130">
        <property type="entry name" value="GATase1_CobB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00027">
        <property type="entry name" value="CobB_CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004484">
        <property type="entry name" value="CbiA/CobB_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011698">
        <property type="entry name" value="GATase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00379">
        <property type="entry name" value="cobB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002204">
        <property type="entry name" value="PRK01077.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43873">
        <property type="entry name" value="COBYRINATE A,C-DIAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43873:SF1">
        <property type="entry name" value="COBYRINATE A,C-DIAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07685">
        <property type="entry name" value="GATase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51274">
        <property type="entry name" value="GATASE_COBBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="2 7 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobQ/CobB/MinD/ParA nucleotide binding" evidence="8">
        <location>
            <begin position="9"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="CobB/CobQ-like glutamine amidotransferase" evidence="9">
        <location>
            <begin position="255"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="338"/>
        </location>
    </feature>
    <feature type="site" description="Increases nucleophilicity of active site Cys" evidence="7">
        <location>
            <position position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIF83795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="465" mass="50075" checksum="96C13B824EABE591" modified="2014-10-29" version="1">MATVAVPRIVVAGVTSGVGKTTVAVAIMHTLRKKKGLAVQPFKVGPDFIDPSYHTFVTGRKSRNLDVWLMGRQGVIDCFNSACESADVAVIEGVMGLFDGMSGKDNFASTAHVAKILGAPVVLVVDASKSARSIAAIALGFTHFDRSVRIAGIILNNVASDRHAGYLSEALAGKVRRVPVLGVIRRNSEIKMDERHLGLVPAQELQKKKRAAILDAAKYVSEQIDIDSILKACGTGPLPASSSAMKKAPKKKATTIAVALDESFNFYYADNLDALRRAGARLVFFSPVNDARLPEGIDGVMLGGGFPEVLADKLEKNRPMIKSVAKAVNAGMPVYGECGGLMYLTRSISGYKGEKKTRRMAGLIDADTVMTSRLTLNYTEADCDGPVFGRANLRGHEFHYSAIEDISRDSRFAYAMKKGKGVTDGRDGFVIGETGLAAYMHLHFASKNNVLAERLVRSCASYLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRT4</accession>
    <name>A0A075MRT4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Neurotransmitter-gated ion-channel transmembrane region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_00040</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158384849.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRT4"/>
    <dbReference type="STRING" id="1459636.NTE_00040"/>
    <dbReference type="GeneID" id="41595992"/>
    <dbReference type="KEGG" id="nev:NTE_00040"/>
    <dbReference type="eggNOG" id="arCOG09466">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075232_0_0_2"/>
    <dbReference type="OrthoDB" id="11176at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
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        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="303"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="3">
        <location>
            <begin position="205"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF82124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="320" mass="35533" checksum="3BECB1F50B09F8DC" modified="2014-10-29" version="1">MYKIAATSLSLAALAAAFFSISMSGAATTTNLAFAQEEEKEKPESRTVGVYLVNVGKVDLQAGSYDIDFYIWFSSDDPNANFTKSAPRFDFMNAFNATITPSQVEPGYYEARVEGTFVKNMDFRQYPFDTQRLTVEVEGFEPVEKLVFKPDTASSGFDDLINVPGWTLDGSSSEVINHHYREGTFSRYIFAFAIERAPLSAFLKTIFPVLIITAIAMLAFWMSPAHFAARVSLAASTLLAAVAAHLSAANQLPPIGYLTFMDKIMIIVYALFLNNLLSLVLQMRLVDRGKEQEALRVNARMRRLMPVIIVVILAILVPFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRV4</accession>
    <name>A0A075MRV4_9ARCH</name>
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        <submittedName>
            <fullName evidence="3">F5/8 type C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_02182</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1459636.NTE_02182"/>
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        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FA58C"/>
    </dbReference>
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        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F5/8 type C" evidence="2">
        <location>
            <begin position="38"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF84236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="582" mass="62818" checksum="41ACD5F491FBE27E" modified="2014-10-29" version="1">MRISATVNHLMKMPDRGGISKRLVFLSVGAMLVLSLPAAAGAIPYASAAPACVALQVTKVSASGNDGNVPKNTIDGKLGTRWSNLGKGSWISMDLGGIVNVCYVDIAWYKGDTRQNTFVISHSPDGRTYIQDYSAKSSGTTASLQRYNFADVSARFVRITVNGNTENNWASITEIKVYGYVSGGTQDTIRPFVTIDQPADRSEIVTSSSTATTATVNIMGKASDSTSGVKLVEVRTDNNAYQPASPASPGDWSTWTNSRTLAVGNHEIAARATDNAGNQQVFTISVKVSQKPADTPSPPTTPPGPGPTPTKDRFGITKINPTAAGGMEWSSSWDNGHARTIGNAIDPDDKWFDAAHGEGRYAIDGKGTLTASGDFVRMYVHDPAKEREWSENLEITMYIKRISETRTVDYSGLQVFARTNHGTNGNEESNLCDDRGYGGLVNINGEWSFEKETAHHLDNGYAGAAGERPSGDLPKNTWVGFKYVLRNMDDNTKVKLELYRDTTGGANGGNWQKVTEFVDSGKNFGNGHGACRSGVNPALPLIHSFINSSSESKEPMLTVYARHEYGTMAYSDFTIREIDPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRV8</accession>
    <name>A0A075MRV8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700852.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRV8"/>
    <dbReference type="STRING" id="1459636.NTE_02187"/>
    <dbReference type="GeneID" id="41597909"/>
    <dbReference type="KEGG" id="nev:NTE_02187"/>
    <dbReference type="HOGENOM" id="CLU_201545_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="72" mass="7649" checksum="F2E0CFA8450CD1A8" modified="2014-10-29" version="1">MERINGETIAGAALALLGALFMFAAQMNTTWAAAVPAALVLIAVGIALVVLGRYTTKKSNRSHPHTEEHSHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRW0</accession>
    <name>A0A075MRW0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Response regulator with CheY-like receiver, AAA-type ATPase, and DNA-binding domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NTE_01494</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700306.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRW0"/>
    <dbReference type="STRING" id="1459636.NTE_01494"/>
    <dbReference type="GeneID" id="41597283"/>
    <dbReference type="KEGG" id="nev:NTE_01494"/>
    <dbReference type="eggNOG" id="arCOG02391">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1096739_0_0_2"/>
    <dbReference type="OrthoDB" id="9652at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032993">
        <property type="term" value="C:protein-DNA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00156">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038723">
        <property type="entry name" value="ArnR1-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="REGULATOR OF RPOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111:SF67">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN TCTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14947">
        <property type="entry name" value="HTH_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="143"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="93"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="110"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF83557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="270" mass="30018" checksum="B63A0825552AD451" modified="2014-10-29" version="1">MASGTEDITGSFSFDVTKRILEALETSGPMKKTNLATKTGLNYNVCLRYIKMLKLLEWIEVSSDKWDYVSITEVGRQVNGKLLSPSAVVNASVPDAKNKQAEEEGRGGFQFQQRPPQSSGRSLSEKAAVRSDDRADTAHEFRSIMLVDDEPDILVTYQSFLSLEGYSVGAFLDAYSALRDFAARPTYYDLVILDIRMPDLNGLQIYQSLKAMNPSCKVIFITALDAAKEMISILPGVTSEDIMKKPIDKEVFLKKVRHILSKNSVGTRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MS12</accession>
    <name>A0A075MS12_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01539</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MS12"/>
    <dbReference type="STRING" id="1459636.NTE_01539"/>
    <dbReference type="KEGG" id="nev:NTE_01539"/>
    <dbReference type="HOGENOM" id="CLU_2839204_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="65" mass="6931" checksum="440CFE3E7EFC1115" modified="2014-10-29" version="1">MGLLTWIVVGIVVLAIIGLGWQTFFSGIIQGAKKIGDNPVIENVTNAAKDRLDDLTGDIVIIRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MS66</accession>
    <name>A0A075MS66_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Plastocyanin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_00132</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699255.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MS66"/>
    <dbReference type="STRING" id="1459636.NTE_00132"/>
    <dbReference type="GeneID" id="41596073"/>
    <dbReference type="KEGG" id="nev:NTE_00132"/>
    <dbReference type="eggNOG" id="arCOG02926">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_848877_0_0_2"/>
    <dbReference type="OrthoDB" id="11836at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000923">
        <property type="entry name" value="BlueCu_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052721">
        <property type="entry name" value="ET_Amicyanin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36507">
        <property type="entry name" value="BLL1555 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36507:SF1">
        <property type="entry name" value="BLL1555 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00127">
        <property type="entry name" value="Copper-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Blue (type 1) copper" evidence="4">
        <location>
            <begin position="245"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="210"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="220"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF82214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="327" mass="34892" checksum="3B543E52C95BABFF" modified="2014-10-29" version="1">MNTKKHMMLLATVAAAVLVVGMISVASLNGASFAYADKEQMQHPGSSMTMTAAPSSPAKGAALGTISSIQNDEKGQPAWIAAGGWKLFLMPSESKNNSTTSAAPDAKFSARFIMTKLDGTSKHEHAISDFVLTNMSDDGNTTTLTGNATMTMKDAPQKNIPMTIKIMNHNIISIMLDPHVNSHLGNTPLYGTVLRANNGYHTMAHMGENKTMMSDNSNSSDKDKEKSSAKEEGRATTIDIVSGAANKGDKSFSPNPVAIKAGTEVTWKNADSALHTVTSGKNSTPDNVFDSSILVPKKDFTFKFNSAGTYDYFCQLHPTMIGEVTVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MS76</accession>
    <name>A0A075MS76_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Flagellin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NTE_02354</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Archaeal flagellum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the archaeal flagellin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700986.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MS76"/>
    <dbReference type="STRING" id="1459636.NTE_02354"/>
    <dbReference type="GeneID" id="41598070"/>
    <dbReference type="KEGG" id="nev:NTE_02354"/>
    <dbReference type="eggNOG" id="arCOG01829">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084671_0_0_2"/>
    <dbReference type="OrthoDB" id="19112at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097589">
        <property type="term" value="C:archaeal-type flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097588">
        <property type="term" value="P:archaeal or bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013373">
        <property type="entry name" value="Flagellin/pilin_N_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002774">
        <property type="entry name" value="Flagellin_arc-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02537">
        <property type="entry name" value="arch_flag_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35903">
        <property type="entry name" value="FLAGELLIN B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35903:SF1">
        <property type="entry name" value="FLAGELLIN B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01917">
        <property type="entry name" value="Flagellin_arch-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0974">Archaeal flagellum</keyword>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="6" id="KW-0282">Flagellum</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF84406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="218" mass="22557" checksum="6FE65FF06C9B2583" modified="2014-10-29" version="1">MIPRRGVTGVESAIVLIAFVIVAAAIAYVVLNSGFQTTEKAKSAITSGLSEASSGIEVAGAATGKGNVTNAVVAAYTIPAKLAAGGSSIDIAPDKMIIRYSSKAVSYDNIYSGIMSNTTFASMDDAIQQAKDENMIVRKPGEGAGPANTAAIVYFTTNTNNNKVLDPAEQIMILVVFKDAERPAALDVARLEVIPASGAPLSVERTIPPVADAVIRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MS97</accession>
    <name>A0A075MS97_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dienelactone hydrolase-like enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699262.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MS97"/>
    <dbReference type="STRING" id="1459636.NTE_00142"/>
    <dbReference type="GeneID" id="41596081"/>
    <dbReference type="KEGG" id="nev:NTE_00142"/>
    <dbReference type="eggNOG" id="arCOG06847">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082991_0_0_2"/>
    <dbReference type="OrthoDB" id="12087at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041127">
        <property type="entry name" value="PET_hydrolase/cutinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12740">
        <property type="entry name" value="PETase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PET hydrolase/cutinase-like" evidence="1">
        <location>
            <begin position="129"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="267" mass="29474" checksum="267566B4FF2ED3DA" modified="2014-10-29" version="1">MQGRRRDYDNDDDDDKNEQSVDISLDSGVLLHGNLKVFDDDNNSLSKIVLFAHGSGSGRYSPRNRYVASVLNKTRIGTLLFDLLTEEEEIVDEQTRHYRFDISLLADRLVRVTDWLLLQNGGFANNNHLRIGYFGASTGAAAALVAAAERPNAVQAVVSRGGRPDLATTKSLAQVRAPTLLIVGQNDEPVIELNWEAFGNLQLLANDKKELVIIPGATHLFEEPGKLEQVAQLATSWFARFLGGDIKEKNHDEDGTKKSDMAAEATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSD7</accession>
    <name>A0A075MSD7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02446</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSD7"/>
    <dbReference type="KEGG" id="nev:NTE_02446"/>
    <dbReference type="HOGENOM" id="CLU_2044302_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="120" mass="13315" checksum="9401F6EAC486AC8B" modified="2014-10-29" version="1">MSVKSGFLANHGHATPEYDIQSSSRKGKEEKDWISCCQPIATGSELGSPSLFMVHAKPYDCGLHNPAMCLERYNTCYLICGPATESLFATSPNFSKFFMNIDASFLACFSYSSFSFHILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSH7</accession>
    <name>A0A075MSH7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mg-chelatase subunit ChlD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700750.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSH7"/>
    <dbReference type="STRING" id="1459636.NTE_02056"/>
    <dbReference type="GeneID" id="41597795"/>
    <dbReference type="KEGG" id="nev:NTE_02056"/>
    <dbReference type="eggNOG" id="arCOG02902">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_472995_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00198">
        <property type="entry name" value="vWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051266">
        <property type="entry name" value="CLCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041523">
        <property type="entry name" value="post_COAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10579">
        <property type="entry name" value="CALCIUM-ACTIVATED CHLORIDE CHANNEL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10579:SF43">
        <property type="entry name" value="ZINC FINGER (C3HC4-TYPE RING FINGER) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17963">
        <property type="entry name" value="Big_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="77"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="576" mass="58815" checksum="8A9EE611A079F3A7" modified="2014-10-29" version="1">MRASQQLLAVAVIGVLVFAATGAVRPAAAASDNQVLVSKTASPADIFVQGAGSPDSTQVTLTVQGFGGTLTETVPIDVVFAIDSSGSMTINDPSNLRIAAAKSFVDKLNSTRDQGGVVSWDDNVDFAFGLTQDFGALKTNINSVDASGGTNLNAGLNGAISMLDGNTRSGSSTEVIIFLTDGVGTYTPAGSGGPAANAAGKGYKIYSIALGGASTGPLTDMASATGGQFFNAPSAANLDAIFNAILQQIVINTAPFNVNLVETTQDYIVDESSFSIAPDSIVTLPGGQTQITWNNVAQHVGDGDNKLLATETFAVTFDASSTLAGNNLPVDDLAESHVQYTNPDGTPGTADIPQAFINVQGPPVAVDDSANTLEDTPVTIGVLANDSDPNGDALTVISVSPPAQGTAVINGDGTITYTPDPSIFGASDTFTYTIDDGHGLTDTATVTVNVQGLTSTPGKVTGGQANLDNNTNAGFNVQSGDGTTFKGQLQFNDKLEDIKLHSQSMTALAIDPTGTTATFKGTAEVNGVSGYTFKAIVKDNGEPGTNDSFLIVIKDLSNTTIYMRGGTLSGGNIQIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSI1</accession>
    <name>A0A075MSI1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00222</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158384929.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSI1"/>
    <dbReference type="STRING" id="1459636.NTE_00222"/>
    <dbReference type="GeneID" id="43502549"/>
    <dbReference type="KEGG" id="nev:NTE_00222"/>
    <dbReference type="HOGENOM" id="CLU_3112872_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="50" mass="5818" checksum="A065FBFD44B8CA11" modified="2014-10-29" version="1">MRVDSLDDTIKFCKDNIYAFEPALEMLDEEYNLKLGGAKYRETKTNVAAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSI3</accession>
    <name>A0A075MSI3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lactoylglutathione lyase-like lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02028</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSI3"/>
    <dbReference type="STRING" id="1459636.NTE_02028"/>
    <dbReference type="KEGG" id="nev:NTE_02028"/>
    <dbReference type="HOGENOM" id="CLU_046006_10_4_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36437">
        <property type="entry name" value="GLYOXALASE/BLEOMYCIN RESISTANCE PROTEIN/DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36437:SF2">
        <property type="entry name" value="GLYOXALASE_BLEOMYCIN RESISTANCE PROTEIN_DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="12"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="131" mass="14653" checksum="514532A87629BCB1" modified="2014-10-29" version="1">MNFKFTMEIIRQLKMLSVPVTNMVNAKKFYVDALGLKMINDFRQDDSHWWVSLILPEGGVTITLATHHENMKPGTMKVYFATSDVAAAHKELSNKGVKVGEVKDDLFGPGSGVKWFNLEDPDGNQVLLVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSM4</accession>
    <name>A0A075MSM4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02079</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700766.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSM4"/>
    <dbReference type="STRING" id="1459636.NTE_02079"/>
    <dbReference type="GeneID" id="41597814"/>
    <dbReference type="KEGG" id="nev:NTE_02079"/>
    <dbReference type="HOGENOM" id="CLU_196478_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="85" mass="9369" checksum="6F1B50F1EC953BC1" modified="2014-10-29" version="1">MQETTATFSREKEEGDNLYFALCESCYWAASVLGSKCCLCTCPSCRNDRVAFIPLCGDESYRYALSETQGLNLQFSTRPGSATTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MT32</accession>
    <name>A0A075MT32_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Iron (Metal) dependent repressor, DtxR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NTE_02317</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DtxR/MntR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MT32"/>
    <dbReference type="STRING" id="1459636.NTE_02317"/>
    <dbReference type="KEGG" id="nev:NTE_02317"/>
    <dbReference type="eggNOG" id="arCOG02099">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069532_4_1_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050536">
        <property type="entry name" value="DtxR_MntR_Metal-Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001367">
        <property type="entry name" value="Fe_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036421">
        <property type="entry name" value="Fe_dep_repressor_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022687">
        <property type="entry name" value="HTH_DTXR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022689">
        <property type="entry name" value="Iron_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33238">
        <property type="entry name" value="IRON (METAL) DEPENDENT REPRESSOR, DTXR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33238:SF7">
        <property type="entry name" value="IRON-DEPENDENT TRANSCRIPTIONAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02742">
        <property type="entry name" value="Fe_dep_repr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01325">
        <property type="entry name" value="Fe_dep_repress"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00529">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47979">
        <property type="entry name" value="Iron-dependent repressor protein, dimerization domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50944">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH dtxR-type" evidence="5">
        <location>
            <begin position="21"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF84370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="154" mass="17636" checksum="63F10AC552BD7687" modified="2014-10-29" version="1">MESLKSRKSDDEELFIGTAESEHVEMYLKAIWYIREKGEEVKVSSIAKLLNVTQPSVVQMLRKLNDLDLVHYTKGSVELTSEGDRIGKQMIRNTRLLEVLMKDALKIEIDEEMVCGIEHHMKNIFTDALCTLLKHPRKCPHGHNIPRGRCCSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MT75</accession>
    <name>A0A075MT75_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">YtkA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02709</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MT75"/>
    <dbReference type="STRING" id="1459636.NTE_02709"/>
    <dbReference type="KEGG" id="nev:NTE_02709"/>
    <dbReference type="eggNOG" id="arCOG08800">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1792194_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="145" mass="15922" checksum="70AD1D59E187E80B" modified="2014-10-29" version="1">MRLSQYRLAVALISMISTISLIPLAFASYIVLMTPSIPKAITIDNLSVKEAIVGQQLVITTTVQSNLKEARSYAIIIEARDYDGVTMAMNWQTGNMDAHGSTSMGMSWIPQKAGTYQLRTFVMSGIHNAQVYSAVESSEIKISTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTD9</accession>
    <name>A0A075MTD9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701039.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTD9"/>
    <dbReference type="STRING" id="1459636.NTE_02420"/>
    <dbReference type="GeneID" id="41598129"/>
    <dbReference type="KEGG" id="nev:NTE_02420"/>
    <dbReference type="HOGENOM" id="CLU_114820_0_0_2"/>
    <dbReference type="OrthoDB" id="5955at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="179" mass="20238" checksum="22D2ED207DBA9093" modified="2014-10-29" version="1">MSSGRYFNKGVKALDLPHVGHVVRESENAIVVFGEGGDRYDIPKQAIRFAAANVLVDLPFSEIVKRYKVSRDAPLPSGMKVHEEAPGDVDLATYEKKYPKPLFNKGVRSQDEEHVGHVMKETDEMIIVWGHRDWRFDIPKSKIIATGRNVIVGLDYKDVFQYRVDRDAPIPSEEATAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTK4</accession>
    <name>A0A075MTK4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Electron transfer flavoprotein beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02476</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701084.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTK4"/>
    <dbReference type="STRING" id="1459636.NTE_02476"/>
    <dbReference type="GeneID" id="41598181"/>
    <dbReference type="KEGG" id="nev:NTE_02476"/>
    <dbReference type="eggNOG" id="arCOG00446">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060196_2_1_2"/>
    <dbReference type="OrthoDB" id="6635at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012255">
        <property type="entry name" value="ETF_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN BETA-SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294:SF17">
        <property type="entry name" value="PROTEIN FIXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000090">
        <property type="entry name" value="Beta-ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Electron transfer flavoprotein alpha/beta-subunit N-terminal" evidence="1">
        <location>
            <begin position="26"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="292" mass="31881" checksum="F63E522A65E366BE" modified="2014-10-29" version="1">MPNLNVAVIIKLEPDFSEGNVSYNADGTLNRAETKSILGPHSAIACQAAFYARVKFGAKVSVGTMGPPNADAALAQAQLICDAEELHLYSDRTFAGADTLATAETLRAGIAKMDGKMDIVFSGHRASDGETGQTGPQTAWKLGFTFLGHVVSYDIDLERRVVRARRLISLQGVYDVIEEVEAPLPVFIAIDPSYKPSFDTVSQRLALEKYQKEAKERSADYKRHLKTFNAQQLQVDPKMVGLPGSPTIVYKVEKIPKAKASRKAEVIDGTNREQLHRVAAKIHEVLGGMVIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTS5</accession>
    <name>A0A075MTS5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02538</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTS5"/>
    <dbReference type="KEGG" id="nev:NTE_02538"/>
    <dbReference type="HOGENOM" id="CLU_2565544_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="81" mass="9334" checksum="4C4AB52BC2055D28" modified="2014-10-29" version="1">MMVSHFDAERRIDHIGINGEVITIYSTDGCETPISVAYGTSLQKIHQLIEERCNLYNIWYASVEHIRILFRTAMLHAVKVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTS7</accession>
    <name>A0A075MTS7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcriptional regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00609</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1459636.NTE_00609"/>
    <dbReference type="KEGG" id="nev:NTE_00609"/>
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    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="74" mass="7597" checksum="6379AD7069210A1C" modified="2014-10-29" version="1">MGAVKGNKGAGAALLAAAIIVFFAYAYAMFGTQYSMIIMKATMVGAVGVLLAVLGWIGYTMLTAPKEDKTATSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTT5</accession>
    <name>A0A075MTT5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH dehydrogenase subunit J</fullName>
            <ecNumber evidence="2">1.6.5.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02553</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.6.5.3" evidence="2"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701141.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTT5"/>
    <dbReference type="STRING" id="1459636.NTE_02553"/>
    <dbReference type="GeneID" id="41598248"/>
    <dbReference type="KEGG" id="nev:NTE_02553"/>
    <dbReference type="eggNOG" id="arCOG04654">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085957_2_2_2"/>
    <dbReference type="OrthoDB" id="10566at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1200">
        <property type="entry name" value="NADH-ubiquinone/plastoquinone oxidoreductase chain 6, subunit NuoJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001457">
        <property type="entry name" value="NADH_UbQ/plastoQ_OxRdtase_su6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042106">
        <property type="entry name" value="Nuo/plastoQ_OxRdtase_6_NuoJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33269">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33269:SF17">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00499">
        <property type="entry name" value="Oxidored_q3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="175" mass="18436" checksum="9C5378515EFB60D9" modified="2014-10-29" version="1">MVDPVFVGLAVLTVGSAIIALETRELIYGAIGLAISMLGIAGFFLILDAPFVAMFQIAVYVGAVAVLLIFTVMLVRTQALFTTKEDKGRKAGGIVLMLFIMGGLGALLLASGLNSSNSFAAPPVNFMKIGQEMLTYYAPVLIVLGLVLAGSVIAALALARREDIVTEQEEGQQQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTU0</accession>
    <name>A0A075MTU0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NADH dehydrogenase subunit B</fullName>
            <ecNumber evidence="7">1.6.5.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NTE_02558</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the complex I 20 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.3" evidence="7"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_075054412.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTU0"/>
    <dbReference type="STRING" id="1459636.NTE_02558"/>
    <dbReference type="GeneID" id="41598253"/>
    <dbReference type="KEGG" id="nev:NTE_02558"/>
    <dbReference type="eggNOG" id="arCOG01554">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055737_4_1_2"/>
    <dbReference type="OrthoDB" id="5740at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12280:FF:000002">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006138">
        <property type="entry name" value="NADH_UQ_OxRdtase_20Kd_su"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01957">
        <property type="entry name" value="nuoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005012">
        <property type="entry name" value="PRK06411.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11995">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11995:SF14">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56770">
        <property type="entry name" value="HydA/Nqo6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-1278">Translocase</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase-like 20kDa subunit" evidence="6">
        <location>
            <begin position="53"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF84605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="173" mass="19291" checksum="4275919578BF723F" modified="2014-10-29" version="1">MNKELVSPTPNNFNVLVTKLSDVLVRALDRPLGYAINWGRIWSLWPVHLETACCSVEFGAASSPRYDVERFGIIEAFGSLRMCDLIVVQGTVTRKMAPRLRMVYDQMPEPKYVIAMGACAITGGLYIDSYNVLPGCDGIIPVDVYVPGCPPRPETLIQGCMLLQEKIKRQKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MU24</accession>
    <name>A0A075MU24_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative xylanase/chitin deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_00704</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699686.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MU24"/>
    <dbReference type="STRING" id="1459636.NTE_00704"/>
    <dbReference type="GeneID" id="41596559"/>
    <dbReference type="KEGG" id="nev:NTE_00704"/>
    <dbReference type="eggNOG" id="arCOG02876">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_580889_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0858">Xylan degradation</keyword>
    <feature type="domain" description="NodB homology" evidence="2">
        <location>
            <begin position="86"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF82784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="470" mass="52387" checksum="DE36943579ADE7EF" modified="2014-10-29" version="1">MYTSYRPIDDSKDRRKRVGAKVKITARTLLAVSAALVLVLGILVSVPRSAYADDESSNNSNNNPEACNCVIFRLDDVQDYWLSDVQVAVMEKFISEHEKLTLGIITNYIGEDDNVVNAVKHGLDSGNFEVVNHSQNHESYADMSAEEQYNDLSNANGNITSLFGISPVGAFIPPFHEYNEDTLAALQDLDMKVISAQFNLELPEIYNPGNPDSPDNKIYRAFEGSDIKDDFGIYHLPQTIGYYDHGTFPHEKVEIENIMASIDEAISSYGYAVVTLHPQDFAVKDNDGNATEEVSTSELGDLDQLFSDITDRGYTTKTFSQAVTPGSDGWSGDNDSNSNGSNSSQNGIGRRPVYNDYLAYFITTYVAGNGTANLPAHDNEANYNNNFLMRAYPIDYLFTIEATYKTHDENILQWNNQYKVVKIDDGPIMHWHDLTDGQKVWLIQTFDHIYSTADVDKLIAGLMTKASEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUD9</accession>
    <name>A0A075MUD9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701243.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUD9"/>
    <dbReference type="GeneID" id="41598370"/>
    <dbReference type="KEGG" id="nev:NTE_02680"/>
    <dbReference type="eggNOG" id="arCOG01055">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_159725_0_1_2"/>
    <dbReference type="OrthoDB" id="140255at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038723">
        <property type="entry name" value="ArnR1-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14947">
        <property type="entry name" value="HTH_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ArnR1-like winged helix-turn-helix" evidence="1">
        <location>
            <begin position="8"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="100" mass="11645" checksum="D377EAA3BF8BAAF9" modified="2014-10-29" version="1">MSERKNNRGKIEIMADVLTLSTVGIKKTHIMYKANLSYEQILYYLNELLGKGLLTQDIMEGSPVYRTTEKGREFLHYFNRMADLIKGYPEEQQKVQLVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUI5</accession>
    <name>A0A075MUI5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GINS complex protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUI5"/>
    <dbReference type="STRING" id="1459636.NTE_02736"/>
    <dbReference type="KEGG" id="nev:NTE_02736"/>
    <dbReference type="eggNOG" id="arCOG00552">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128581_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd11714">
        <property type="entry name" value="GINS_A_archaea"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038437">
        <property type="entry name" value="GINS_Psf3_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GINS subunit" evidence="1">
        <location>
            <begin position="131"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="211" mass="23663" checksum="38B7F5ABB3660146" modified="2014-10-29" version="1">MSYKSSRKLAESSAKIVLTKDITEHQLLQFANMADSPAADSRIEAIQDAYHVGYMNEEVRISYKRDVKLAVGAVAIDAKEGDMSSLPRWVAKILSEQGAIEIQSNDIAGYISRTLNRERIARPHDLSGIDIDFYVRVNDHLDTLRERERENLAVSLNTFVASRLEKIVKLAAASPLSAELEGRLAAEEKELYRTIHEASTKFKRGVLKKFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUL1</accession>
    <name>A0A075MUL1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">7-cyano-7-deazaguanine synthase</fullName>
            <ecNumber evidence="9">6.3.4.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NTE_02762</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>7-carboxy-7-carbaguanine + NH4(+) + 2 ATP = 7-cyano-7-carbaguanine + 2 AMP + 2 diphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:27982"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:45075"/>
            <dbReference type="ChEBI" id="CHEBI:61036"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; 7-cyano-7-deazaguanine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the QueC family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.20" evidence="9"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701313.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUL1"/>
    <dbReference type="STRING" id="1459636.NTE_02762"/>
    <dbReference type="GeneID" id="41598451"/>
    <dbReference type="KEGG" id="nev:NTE_02762"/>
    <dbReference type="eggNOG" id="arCOG00039">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081854_1_0_2"/>
    <dbReference type="OrthoDB" id="6532at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01995">
        <property type="entry name" value="QueC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018317">
        <property type="entry name" value="QueC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42914">
        <property type="entry name" value="7-CYANO-7-DEAZAGUANINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42914:SF1">
        <property type="entry name" value="7-CYANO-7-DEAZAGUANINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06508">
        <property type="entry name" value="QueC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006293">
        <property type="entry name" value="ExsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIF84803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="234" mass="25643" checksum="6EDBB049AB1CC2CA" modified="2014-10-29" version="1">MPRQAAAVCIVSGGLDSVCYAATLARDYDIYMITFAYGQRARREIDAARYFARVLKAKEHRIVDISFMKGLYGKSNALTDGRQELSKDFSQSLVVPIRNAIFIAIAGAWAMSINARAVAYGAHSGDVPHYADCRPEFAKAMAEALNIADIDSIRSGQRQQIEIASPAVQGLSKSELLKAGRATLGDSLFRTWSCYSNGVRRAGKYVHCGACESCISRKKAFTDAQIHDRTRYAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUP3</accession>
    <name>A0A075MUP3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02813</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_264357912.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUP3"/>
    <dbReference type="STRING" id="1459636.NTE_02813"/>
    <dbReference type="GeneID" id="75933633"/>
    <dbReference type="KEGG" id="nev:NTE_02813"/>
    <dbReference type="HOGENOM" id="CLU_3282992_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="40" mass="4744" checksum="3C1A9EA41E72799C" modified="2014-10-29" version="1">MMLVRCYTCNRVFDIDKPAERKEAIKHSQACHEMTRGFRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUT1</accession>
    <name>A0A075MUT1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03393</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701834.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUT1"/>
    <dbReference type="STRING" id="1459636.NTE_03393"/>
    <dbReference type="GeneID" id="41599039"/>
    <dbReference type="KEGG" id="nev:NTE_03393"/>
    <dbReference type="HOGENOM" id="CLU_2747971_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="70" mass="7993" checksum="79B063FD288616D4" modified="2014-10-29" version="1">MKGGYRHGNYFLHRVNVVNGSVVGKLPEVPAMRKAYLKYYAHAKTVRELEAHVFWRFELAAAGVLESMMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUY8</accession>
    <name>A0A075MUY8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphosulfolactate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphosulfolactate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987179.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUY8"/>
    <dbReference type="STRING" id="1459636.NTE_01035"/>
    <dbReference type="GeneID" id="41596858"/>
    <dbReference type="KEGG" id="nev:NTE_01035"/>
    <dbReference type="eggNOG" id="arCOG00394">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG04896">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062679_2_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003830">
        <property type="entry name" value="ComA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036112">
        <property type="entry name" value="ComA_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48413">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48413:SF1">
        <property type="entry name" value="PROTEIN HEAT-STRESS-ASSOCIATED 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02679">
        <property type="entry name" value="ComA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102110">
        <property type="entry name" value="(2r)-phospho-3-sulfolactate synthase ComA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="353" mass="39458" checksum="718E5C7C2B5FBBE8" modified="2014-10-29" version="1">MTLNAQYATDNLEICAESAYIAYSNMLDGLAKNRLDAKKPRKEGLTCTIDKFQGLDRENFATIAPFVDVVKVYGALPMLVSDESLRKKIEYYHGFDIKVSTGSTITEFAVVESSLERFAREAAKVGFDMVEIGESSIDLSIAQKKKITEAVKAAGLEYQWKVGKKDPRHQLGIDDTLKKIDEAVKLDSKKVVIEANEGYNVGIYDEKGLVKWSFVGAMTNEYPPSTFIFEAPLESQQSALMAEFGQRVNLAEVHPEAIASVESQRRGFLAKSAFGVSYIRKDPEGGPASKFIYYIIRTKHPVEQGELISLSHLPRRTVQAAVDDLKRQGLIIERSSLEDARKKVYQPVQSEWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MV20</accession>
    <name>A0A075MV20_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02457</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MV20"/>
    <dbReference type="KEGG" id="nev:NTE_02457"/>
    <dbReference type="eggNOG" id="arCOG02749">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG03065">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_468229_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="551"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="559"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="582" mass="66181" checksum="F9076C8EFD0C6D41" modified="2014-10-29" version="1">MAVHGKDYCVKAVLTALADGRPKSARDVVTTTGIDEKTTFHLLSNMWRKRLILRTDKPLFEYNKQFKGRAGFRSNTRMFHLYVINGQRGQGEVEGERARTEDTPFVIDGHRFVQFSSEYSDKRGNRGSKSKAQLVLNFLKENSDRAFYSTEIFNALKEKGVTMPDIMTTARRYERKGLLYVRGYQTHDSQSPFQEGYLITWIEQQDGGDDLDALKQAVMRTNEALKSKASTNPLVQRVLAIRNLVVSETELGRIASINQIKDALRATDNEVESAIARATKLYPSIREVKLFDAYRYFYHESMNEEVLNAALEMAKNYIRISKGRANRIGHNWEACVEWFIDKFTIGAEFRTQNHRNNGTGRMDPRRITLHLIKSVGDRRQNAEVDRVWTVTPSVFARPVTYVLECKWGLVRRKDLDDFFNVLKWSTDFGVDTPEERQVKNGVVGVFAGGAFEDIHVKVSTVNSKDNSDSTITLAQYAERLNVQLLRAANFNEKLRDKGVPKDATVQKICKAARDERDVRRMLDAVWEKPEDATDVLDRAIKTNSSVFKFEEELEAGDNEGSKGKEKGETLPTGPLSTAAAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MV44</accession>
    <name>A0A075MV44_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Type 2 DNA topoisomerase 6 subunit B</fullName>
            <ecNumber evidence="6">5.6.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Type II DNA topoisomerase VI subunit B</fullName>
            <shortName evidence="6">TopoVI-B</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">top6B</name>
        <name evidence="10" type="ORF">NTE_01081</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Relaxes both positive and negative superturns and exhibits a strong decatenase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer. Heterotetramer of two Top6A and two Top6B chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TOP6B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="6"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385118.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MV44"/>
    <dbReference type="STRING" id="1459636.NTE_01081"/>
    <dbReference type="GeneID" id="41596898"/>
    <dbReference type="KEGG" id="nev:NTE_01081"/>
    <dbReference type="eggNOG" id="arCOG01165">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006403_0_0_2"/>
    <dbReference type="OrthoDB" id="65493at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00322">
        <property type="entry name" value="Top6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005734">
        <property type="entry name" value="TopoVI_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015320">
        <property type="entry name" value="TopoVI_B_transducer"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003218">
        <property type="entry name" value="PRK04184.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48444">
        <property type="entry name" value="DNA TOPOISOMERASE 6 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48444:SF1">
        <property type="entry name" value="DNA TOPOISOMERASE 6 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09239">
        <property type="entry name" value="Topo-VIb_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Histidine kinase/HSP90-like ATPase" evidence="8">
        <location>
            <begin position="58"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="DNA topoisomerase VI subunit B transducer" evidence="9">
        <location>
            <begin position="340"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="618"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="630"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="650"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="135"/>
            <end position="142"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="495"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIF83154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="660" mass="73693" checksum="AC63E232AD8A5D78" modified="2014-10-29" version="1">MTQKVTTAEVASSAAVVKPADVPASQTRAVHRGRVKYDKKAESEFFVDNSALAGFTGERILYMAVRELIENSLDSCESSHILPRISLSLRMVDPANEMWTITCQDNGIGIPSDKVPVAVCSFLTSGKYVEKQQRGLFGVGLKMIAAFSTKDTDHPLKVWSKSLEEGEEYYFELRTDISTNRPIVLAKRQVKEDAAMSGDSGFRVEAMLRAKLSPITKSRIYDYISQTSVVNPYAHIEFETDDGKVAFDRRTDRMPEPAKEVLPHPADMDLKTLKKAIMNFMNQKTTLQGVLSDSFQKLSSEKARQIISEAGLENKPADKYDEHELIKVVNICKQTKFHMPNTDHLSPIGEEILTAGMTQEYTIITNKDEATQQGTQPQLSIKVLKPSLTAYSSRTCVINNRPTIVECGIAYGGDIGSFKLYRFANKIPLLYDEGSDVAREVVSEVEINKMGISKKEVKEQFANPDAKSDRAVELLPLHIFFHICSTKIPYKTAGKESIASEGELKRYMKACLSDLYRKVSAQIRKELRMKEAQSRLSLYKYYIPLIVNAISESIKIDPQKLEQAFTQLAEKHVAGEITSMPVPEKEDEITGERIADEADEEVVAEEIDGEVVKRSKSQIAINAARRKGERSKPMSKKKEGGGQTTLDSVMTKKDSGGRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MV55</accession>
    <name>A0A075MV55_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alanine dehydrogenase</fullName>
            <ecNumber evidence="4">1.4.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_02488</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.4.1.1" evidence="4"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987276.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MV55"/>
    <dbReference type="STRING" id="1459636.NTE_02488"/>
    <dbReference type="GeneID" id="41598192"/>
    <dbReference type="KEGG" id="nev:NTE_02488"/>
    <dbReference type="eggNOG" id="arCOG06678">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003376_3_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000286">
        <property type="term" value="F:alanine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006524">
        <property type="term" value="P:alanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42795">
        <property type="entry name" value="ALANINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42795:SF1">
        <property type="entry name" value="ALANINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01262">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal" evidence="3">
        <location>
            <begin position="4"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding" evidence="2">
        <location>
            <begin position="178"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF84537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="399" mass="42919" checksum="8127BC47AAA51453" modified="2014-10-29" version="1">MTIGVPKEIKDHENRVALTPRSVASLVSSGIKVAVERNAGAKSGFSDADYASAGAQVASDAAELYSKADLVVKVKEIQVGKGEHAHILQKHIIFGYNHFESSRELTSAAIRSGATFISFEKVTDGNGQTPLLMPMSRIAGTLAGIWAGFFHNYAFRHDKSLRMKAGADQVKARFIEDFERIIDGKLDAATANSLSLHDKQVVIFGGGTAGEMASRTCHALGAKLTIVEKRDSRRKYLQGLGLGRCSVVASADYDAIKGASAVIGATYDKEKADRMIDEMTLKNASEVRKKVIIDISIDQGGNFPFVDSTGKYAPESMGTIMSPAQMDYFGNVFVRVPNMPSIVPRYASMALSNAITDHVKAIATNQTRPELVRATSIAGGKVLDEAVARAHSLPYAKTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVI7</accession>
    <name>A0A075MVI7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 13">Valine--tRNA ligase</fullName>
            <ecNumber evidence="2 13">6.1.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">NTE_03216</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>tRNA(Val) + L-valine + ATP = L-valyl-tRNA(Val) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:10704"/>
            <dbReference type="Rhea" id="RHEA-COMP:9672"/>
            <dbReference type="Rhea" id="RHEA-COMP:9708"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78537"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="2 13"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701680.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVI7"/>
    <dbReference type="STRING" id="1459636.NTE_03216"/>
    <dbReference type="GeneID" id="41598873"/>
    <dbReference type="KEGG" id="nev:NTE_03216"/>
    <dbReference type="eggNOG" id="arCOG00808">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001493_0_2_2"/>
    <dbReference type="OrthoDB" id="23906at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004832">
        <property type="term" value="F:valine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006438">
        <property type="term" value="P:valyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07962">
        <property type="entry name" value="Anticodon_Ia_Val"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000192">
        <property type="entry name" value="Valine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033705">
        <property type="entry name" value="Anticodon_Ia_Val"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002303">
        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009687">
        <property type="entry name" value="PRK13208.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00422">
        <property type="entry name" value="valS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946:SF93">
        <property type="entry name" value="VALINE--TRNA LIGASE, CHLOROPLASTIC_MITOCHONDRIAL 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="VALYL-TRNA SYNTHETASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00986">
        <property type="entry name" value="TRNASYNTHVAL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="14">
        <location>
            <begin position="18"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="15">
        <location>
            <begin position="612"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00055630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00061452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="NCBIfam" id="TIGR00422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AIF85245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="786" mass="90371" checksum="044140036AEF2386" modified="2014-10-29" version="1">MEPKIETKSWNHEIESAILKKWQDENTYRFEITSSNKPAFVIDTPPPYPSGKPWHIGAAAHYAQIDMIARTARMSGKNVLFPIGIDRNGLPVEIYTEKKYKVRMRQMDRQKFLDLCKGALDDLEAEMLQIMKNMGLSGDFARYYRTDSDEYRALTQATFIELWKRGLVYLANRPNNYCPDCGTTIADAEIIYDDLPTKLVHMKFQVAGSGDSIVIASTRPELLFACQAVIVNPEDERYLDYQGKSVVLPLFNREVPIKTHHSAKPEFGSGAVMVCSYGDQNDVQVFRELGLKEIVALNENGVTTEAAGAYAGLRVNQARTKVIEDLKAANLVEKEESIMHRTPLCERSKTPIEIIPLHDYYVKQLEYVPQLRELAMQLKFHPEMHRQILLNWLDSVAIDWPVSRRRFYGTEIPIWYCNSCKAPLLPEPGRYYRPWKESPPFEKCPKCGHAEFTGEDRTFDTWMDSSISPLYVTKFNNDQKLFNYAYPTAVRPQAKDIIRTWLHYTMLRCVQLTGKMPWTDAWIMGYGVDEKGEKMSKSKGNVIDPFPIIQQYGADTFRFWSASEANLGYDFRCSEQRIASSQKFLSKLWNVGRFLSSFDVVKDKPANLEASDRWILAELAKLVQECRRGYDEYNFFVPANAIRDFTWNVFAAHYIEMVKGRAYDPSQQGHASALYTLHKVFSTILLLLAPMTPFISEELWVKMYLEKSSIHHQQLPSVIEEQDLEFAKYTKAITDFNSQVWNKKKETISKGTGKPMSLKDPIEIAVPEELEPFAADLVSMHNLISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVK9</accession>
    <name>A0A075MVK9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01239</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385151.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVK9"/>
    <dbReference type="GeneID" id="43502599"/>
    <dbReference type="KEGG" id="nev:NTE_01239"/>
    <dbReference type="HOGENOM" id="CLU_3038864_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="54" mass="5733" checksum="ABFBE88EB0CCDB5D" modified="2014-10-29" version="1">MLGQLFLKICAGSPMCGPVDYQMVLLVLTAVIGSASVGLIGFQRFRKAKPATFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVL5</accession>
    <name>A0A075MVL5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02654</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701222.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVL5"/>
    <dbReference type="STRING" id="1459636.NTE_02654"/>
    <dbReference type="GeneID" id="41598346"/>
    <dbReference type="KEGG" id="nev:NTE_02654"/>
    <dbReference type="eggNOG" id="arCOG08758">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_170065_0_0_2"/>
    <dbReference type="OrthoDB" id="10612at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="117" mass="13686" checksum="9A9DB1D09A1DA476" modified="2014-10-29" version="1">MSASTTPKVSRQDIRQIISDNFNDTDYRFSNDEILGYLNEMDRYKAANLDVLDFEDVLLEMEESGFLRPIAQNFNTRYYKIMTELESKTCKDCNTVSWFAEAEEPKLCPRCRSKNMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVM8</accession>
    <name>A0A075MVM8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Preprotein translocase subunit Sss1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700134.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVM8"/>
    <dbReference type="STRING" id="1459636.NTE_01280"/>
    <dbReference type="GeneID" id="41597083"/>
    <dbReference type="KEGG" id="nev:NTE_01280"/>
    <dbReference type="HOGENOM" id="CLU_2875221_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.820">
        <property type="entry name" value="Preprotein translocase SecE subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023391">
        <property type="entry name" value="Prot_translocase_SecE_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103456">
        <property type="entry name" value="Preprotein translocase SecE subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="62" mass="6680" checksum="CDBF3FB5ABBDEF93" modified="2014-10-29" version="1">MSVVERKIGEIIQTLRLAKKTSRQDYTQHLRLVGLGLGAVGGIAFIIKLVSEFITIGLGGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVX8</accession>
    <name>A0A075MVX8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ribose-phosphate diphosphokinase</fullName>
            <ecNumber evidence="1">2.7.6.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">NTE_01392</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="1"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987204.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVX8"/>
    <dbReference type="STRING" id="1459636.NTE_01392"/>
    <dbReference type="GeneID" id="41597188"/>
    <dbReference type="KEGG" id="nev:NTE_01392"/>
    <dbReference type="eggNOG" id="arCOG00067">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033546_2_2_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000007">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF32">
        <property type="entry name" value="RIBOSE-PHOSPHATE PYROPHOSPHOKINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribose-phosphate pyrophosphokinase N-terminal" evidence="10">
        <location>
            <begin position="8"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AIF83459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="297" mass="30845" checksum="63452C31A8601EE5" modified="2014-10-29" version="1">MAADISSIVAGPSSPELAAGIAKHLGAKLVSAELRVFSDGESKIRLTASIGKKCAVVQSAYPPTDTHLLQAMMMIKKCADDGAEVCAVIPYLAYARQDRAFLEGESVSVALVAKLLAAAGAKSVVTVDIHSEAALAFFSSITNVSSMPLLAAHAASLKLKDALVVSPDTGGIPRAQQFARLLKTDMTALKKSRDRTTGEVTVEQRIDMDVSGRDAILIDDMISSGGSIVKAAEVLRKNGAGKIYAMCAHALLIGDAASKIAAAGVQEIIATNSIPGRHAKVDLSKALAEAVRKALLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MW20</accession>
    <name>A0A075MW20_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Zn-dependent hydrolase of beta-lactamase fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_02776</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701326.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MW20"/>
    <dbReference type="STRING" id="1459636.NTE_02776"/>
    <dbReference type="GeneID" id="41598465"/>
    <dbReference type="KEGG" id="nev:NTE_02776"/>
    <dbReference type="eggNOG" id="arCOG00497">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051050_1_0_2"/>
    <dbReference type="OrthoDB" id="28313at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050114">
        <property type="entry name" value="UPF0173_UPF0282_UlaG_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43546:SF9">
        <property type="entry name" value="L-ASCORBATE-6-PHOSPHATE LACTONASE ULAG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43546">
        <property type="entry name" value="UPF0173 METAL-DEPENDENT HYDROLASE MJ1163-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="2">
        <location>
            <begin position="24"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF84817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="264" mass="28743" checksum="41032F7D3ADE1AF1" modified="2014-10-29" version="1">MNDLKLRFTYIGGPTALIELGGLRFLTDPTFDPPGEYRTSLYVLRKTRGPAIGHDAIGSLDAVLLSHDQHLDNLDTMGRASLDHSARVLTTPAAAKRLGDRAIGLSPWQTIGIPARDGGNSRVLQITGTPARHGPVHADRGPVTGFVLAFADAPEYAVYISGDTVWHEGLVEVSRRFSIRVAVLFMGAARVTEVGPWHLTLTAAEGVKAAHAFSRATTIIPLHFEGWAHYSESRDDIEQAFTAAGLEHRLKWMEPGRPTDLCIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MW35</accession>
    <name>A0A075MW35_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MW35"/>
    <dbReference type="KEGG" id="nev:NTE_03437"/>
    <dbReference type="eggNOG" id="arCOG01471">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2257229_0_0_2"/>
    <dbReference type="OrthoDB" id="10087at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.520">
        <property type="entry name" value="nmb1532 protein domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="103" mass="12509" checksum="8954BCCC0BE15CA4" modified="2014-10-29" version="1">MEEFVDVFHHGKEENAYFPLTKEKNDYSEEIRKFLIEHELGRRIAYMLRRELDTLNDNHDDNDKNRKKGPKWNKDKSKEPVARFLKSYAVFRLTAPFHLRKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWF5</accession>
    <name>A0A075MWF5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701869.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWF5"/>
    <dbReference type="GeneID" id="41599074"/>
    <dbReference type="KEGG" id="nev:NTE_03435"/>
    <dbReference type="HOGENOM" id="CLU_2433703_0_0_2"/>
    <dbReference type="OrthoDB" id="379791at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="90" mass="10196" checksum="4E5389CCCB9BDC24" modified="2014-10-29" version="1">MPTVGAKVSQKEFDAITEYANLCGETVSNLIRKIVVADATILHGGWVDEHPEYECSIPMPQNVSGEEENRILEEKTNKIRRILGWRDIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWT2</accession>
    <name>A0A075MWT2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03073</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWT2"/>
    <dbReference type="STRING" id="1459636.NTE_03073"/>
    <dbReference type="KEGG" id="nev:NTE_03073"/>
    <dbReference type="eggNOG" id="arCOG08805">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100103_1_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="Ribbon-helix-helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="185" mass="21424" checksum="FA318D5F6CA141DF" modified="2014-10-29" version="1">MNKSTANDHDVKKKERTETITFRLPSALIDELRTDAELEGVSLNNYAAKIFSNHVQWERYERKVGLLPMTEAFLKETLGQLTDEQVINLAQKIEKQKFKNILAFMKDSHDVADFVELIRTWLNVSWMQQNVELRNGTYQFKIQHNLGSKWSLYVKTLIAELAQDVLGKKAVIKTMAETISFSFPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MX05</accession>
    <name>A0A075MX05_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein NTE_01748</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_01748</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987244.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MX05"/>
    <dbReference type="STRING" id="1459636.NTE_01748"/>
    <dbReference type="GeneID" id="41597518"/>
    <dbReference type="KEGG" id="nev:NTE_01748"/>
    <dbReference type="eggNOG" id="arCOG01336">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095686_1_1_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.700.20">
        <property type="entry name" value="Hypothetical protein ph0010, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.150">
        <property type="entry name" value="Hypothetical protein ph0010, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00645">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023473">
        <property type="entry name" value="AMMECR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036071">
        <property type="entry name" value="AMMECR1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002733">
        <property type="entry name" value="AMMECR1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027485">
        <property type="entry name" value="AMMECR1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027623">
        <property type="entry name" value="AmmeMemoSam_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023472">
        <property type="entry name" value="Uncharacterised_MJ0810"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04335">
        <property type="entry name" value="AmmeMemoSam_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00296">
        <property type="entry name" value="TIGR00296 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13016:SF0">
        <property type="entry name" value="AMME SYNDROME CANDIDATE GENE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13016">
        <property type="entry name" value="AMMECR1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01871">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143447">
        <property type="entry name" value="AMMECR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51112">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMMECR1" evidence="2">
        <location>
            <begin position="6"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF83809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="208" mass="23221" checksum="D5198BE6420EC41D" modified="2014-10-29" version="1">MMISDAEGAELVRLARLAVEKYVVESVVVKKPAMELPKSGVFVTINYLTRNGEDLRGCIGFPLPYKELHQSVIEAAIAAAVDDPRFPPVDGKELEHLTFEVSVLTEPEEIPGGPVERKKRIAIGRDGLLLKWKHGSGLLLPQVPVELGWDIDEYLANICYKAGAPPDVWLDPSSKLFTFQAAIFKEERPKGDIVRLGTDDRYYYNNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MXP0</accession>
    <name>A0A075MXP0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Site-specific recombinase XerD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_03349</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MXP0"/>
    <dbReference type="STRING" id="1459636.NTE_03349"/>
    <dbReference type="KEGG" id="nev:NTE_03349"/>
    <dbReference type="eggNOG" id="arCOG01242">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027562_2_2_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00397">
        <property type="entry name" value="DNA_BRE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050090">
        <property type="entry name" value="Tyrosine_recombinase_XerCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30349">
        <property type="entry name" value="PHAGE INTEGRASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30349:SF87">
        <property type="entry name" value="TRANSPOSASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="2">
        <location>
            <begin position="182"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF85377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="462" mass="52861" checksum="983DC15EC122B9C3" modified="2014-10-29" version="1">MLTPGLKKPREAYESQTFLEKADETRTSGRFKATRRSGGVIDSDAIYNYTGKLKAIQRQFKGKEAKLVSDFLNALSDHGLSKGRITYYACRLPKIMKWFRKRRIALKDATKEDCKQCLRDVNSSGDYGGETKSAYAKTLKRLIHFAKTSEIGEKKEGQDYVQEVAWIRPTAYLKQGEKQEIKPSDILTYQELEMLVEAVNKISRYPVRDSAMVICMYEGAFRSGELLRMAIGGVLFKDKVAVISTTGKTGSKTVPLLLSYKPLLEWLQQHPEKDNPDAAVWMGMTRRKVLHYQYLRNLVKDAARQAGIKKKVWNYLLRHTRLTDVARKHPDQILKKYENWKGNTRMVEVYIHLSESDLEDAVLREHGLQQEEKEEKLTLKKCPRCGEGNTIGVKRCVKCGFIIDEQLAMKTVQEEQDVFGSLSKRIERQEEVQDKILEVLGSIARDVEGMKAAEEDDITTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MXR6</accession>
    <name>A0A075MXR6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02032</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MXR6"/>
    <dbReference type="KEGG" id="nev:NTE_02032"/>
    <dbReference type="HOGENOM" id="CLU_2985813_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="59" mass="6933" checksum="69DA7CD7F49FD911" modified="2014-10-29" version="1">MLFVREAELVNMHWDIVKLLSLGVDEKFLQESNITPEQARDLVKGLLYLRERYADQIGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MXU3</accession>
    <name>A0A075MXU3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03409</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MXU3"/>
    <dbReference type="STRING" id="1459636.NTE_03409"/>
    <dbReference type="KEGG" id="nev:NTE_03409"/>
    <dbReference type="HOGENOM" id="CLU_2911322_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="61" mass="6903" checksum="9EF7CAF52401870D" modified="2014-10-29" version="1">MCNPIIKQTAETTEQTIKVYNKVRAKLRLPDITNDTTNCITQYGSLKRSLEKVSANVGRTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MY08</accession>
    <name>A0A075MY08_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03504</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MY08"/>
    <dbReference type="KEGG" id="nev:NTE_03504"/>
    <dbReference type="HOGENOM" id="CLU_1811359_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="142" mass="15925" checksum="361EF091E1659C9C" modified="2014-10-29" version="1">MMQAVRSFEIRTTSAVPSSKIVHRTNFAIAIIGFLASTLPGYFIAANTTSASQEEGRPPNLVREGFVLLTTGRCKISKNDDCYYNDFAVVRHLAIQKHKRAPICTRCRDKASFEVLHETEACYLMRRFCTRCLAGAGYDLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MYK8</accession>
    <name>A0A075MYK8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phosphosugar isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02296</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
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        <property type="protein sequence ID" value="AIF84349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="KEGG" id="nev:NTE_02296"/>
    <dbReference type="eggNOG" id="arCOG00059">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077866_0_0_2"/>
    <dbReference type="OrthoDB" id="34358at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006047">
        <property type="term" value="P:UDP-N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937">
        <property type="entry name" value="GLUCOSAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE, ISOMERIZING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF17">
        <property type="entry name" value="GLUCOSAMINE-FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF01380">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIS" evidence="1">
        <location>
            <begin position="28"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="303" mass="32663" checksum="25C0AF07A5D06E50" modified="2014-10-29" version="1">MNSIEAMAQDVRRQLDDLPRLVLPAPVENNIAFVGSGDSYAAALAACHLSSGQATCWHPADVVFNPLLLAGRSAYFVSISGRTRANVQAASAARKAGIATVALTADKKSPLARACDSVFELDFKGAGRTSGTIGFAASVLACTHLATQGRIGCPANLKEIYAKASRAASRLADKISIAGSTIMLADSFLYPAAMYGALKFNEVFGSRAQAYPLEEFFHAPLFGLKRSDQVLVLGTKDKDAALARRIRGLFVDCTTTPAPVESLFYAMFFIQHLVLAIARKRKLKECYFIRNKKLLRTSSDVIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MYR8</accession>
    <name>A0A075MYR8_9ARCH</name>
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        <submittedName>
            <fullName evidence="2">Archaebacterial flagellin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385435.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MYR8"/>
    <dbReference type="STRING" id="1459636.NTE_02357"/>
    <dbReference type="GeneID" id="41598073"/>
    <dbReference type="KEGG" id="nev:NTE_02357"/>
    <dbReference type="eggNOG" id="arCOG01822">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108339_0_0_2"/>
    <dbReference type="OrthoDB" id="135845at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097588">
        <property type="term" value="P:archaeal or bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002774">
        <property type="entry name" value="Flagellin_arc-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01917">
        <property type="entry name" value="Flagellin_arch-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0282">Flagellum</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="156" mass="16315" checksum="F31E43AE961E9C46" modified="2014-10-29" version="1">MVSAGITEGILLVASVIVAASLSGMVISKTGALNSSFTISAEAQKDVILTKIKTVYVSGNSSSPAVTVWAKNIGSTPITNTDKLDVYFGKVGSTAKIPYNAGSAPKWAYSANMTQWQIKDTVQIDITTASNLSPGSTYVVRLVAPNGVTDEYLFST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MZM2</accession>
    <name>A0A075MZM2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02646</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
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            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_258914178.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MZM2"/>
    <dbReference type="STRING" id="1459636.NTE_02646"/>
    <dbReference type="GeneID" id="75933632"/>
    <dbReference type="KEGG" id="nev:NTE_02646"/>
    <dbReference type="HOGENOM" id="CLU_3245176_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="42" mass="4745" checksum="78A5811524EB5F44" modified="2014-10-29" version="1">MSLFELELEAPAPLTICPKCGRQVRIDGHCECEAIFLTKPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MZS8</accession>
    <name>A0A075MZS8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02692</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MZS8"/>
    <dbReference type="STRING" id="1459636.NTE_02692"/>
    <dbReference type="KEGG" id="nev:NTE_02692"/>
    <dbReference type="HOGENOM" id="CLU_094456_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="257" mass="27836" checksum="8AF1905C3A71F32B" modified="2014-10-29" version="1">MSIKCAECQCDPQDCMKVEHAQRCGTCTKEACCCIAIHNSAKKYASKLTLTKMNDDCCASGVCKNDSIPQKTTSQSGLLQFLRNAKALYAAALGIEILCIVATEIGENTGLYLFGFNQIGIPIAYAMGYALAGFTTFATILGRYNYGSNDRIDGCCSVLEQGAGTGFTSNLKTTFKNLAIGMTKLPQLHRQPNKKYMLKTSAYILVTAESACILTAETIDLVFYQYSLLLSIPLALLAGAFTVVAPEAYRKTKRKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N082</accession>
    <name>A0A075N082_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nitrogen regulatory protein P-II family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02871</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701401.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N082"/>
    <dbReference type="STRING" id="1459636.NTE_02871"/>
    <dbReference type="GeneID" id="41598551"/>
    <dbReference type="KEGG" id="nev:NTE_02871"/>
    <dbReference type="eggNOG" id="arCOG02305">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082268_3_1_2"/>
    <dbReference type="OrthoDB" id="10960at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006808">
        <property type="term" value="P:regulation of nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002187">
        <property type="entry name" value="N-reg_PII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30115">
        <property type="entry name" value="NITROGEN REGULATORY PROTEIN P-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30115:SF11">
        <property type="entry name" value="NITROGEN REGULATORY PROTEIN P-II HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00543">
        <property type="entry name" value="P-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00340">
        <property type="entry name" value="PIIGLNB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00938">
        <property type="entry name" value="P-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="GlnB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51343">
        <property type="entry name" value="PII_GLNB_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="114" mass="12721" checksum="EFE74687F81609AA" modified="2014-10-29" version="1">MKRLDLIIPHERLEEVNEILHKHKVGGMSFYDIKGRGRAKREPVAVGRGVMRYVPEFGFRTKIEVLVADSMAKPIIDDILKNISTGSASDGKIFVYDVAEAYDIGSKETGDEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N0D8</accession>
    <name>A0A075N0D8_9ARCH</name>
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        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">NTE_02916</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987018.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N0D8"/>
    <dbReference type="STRING" id="1459636.NTE_02916"/>
    <dbReference type="GeneID" id="68225779"/>
    <dbReference type="KEGG" id="nev:NTE_02916"/>
    <dbReference type="eggNOG" id="ENOG502N56G">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027719_2_1_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055898">
        <property type="entry name" value="DUF7475"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34315">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34315:SF1">
        <property type="entry name" value="INTRADIOL RING-CLEAVAGE DIOXYGENASES DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24287">
        <property type="entry name" value="DUF7475"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Intradiol ring-cleavage dioxygenases" evidence="2">
        <location>
            <begin position="200"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF84954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="400" mass="43124" checksum="0CA4514CDA87388B" modified="2014-10-29" version="1">MAYSSALYYVAAAATAIAGVLHLTLGPGSLEFNAAGGILFVVGGIAQVFWIIPVVRRWGRPWYYTGIAGTLVLIALWAITRMPGNPITGRGGPVNPIAIAIEVSQAAFVGLLAAILVYEIRKQVVDYRAAPAEKKNNNQLLALVGVVAAIILAGSFVPMSMGRPMGPTSQPGSASQPVAAVQKCTLTPSLIEVEDTPQQIEGPYFVDEKLERSDIRPDPSDGSVQDGVPLRLLLNVYDVDNGSCIPLRNAQVDIWQTNSQGLYSDIASIGTEGKKFLRGYQLTDGNGTVRFTTVYPGWYEGRALHIHVKVRTFEGSAKTFEWTSQFYLDDSVSDKIEAQAPYSDHGPRPLKNNQDFIYTGPSTDGMLQSNTGSHLMLNLTKDNGPGYLGTFNIGVEANRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N0I4</accession>
    <name>A0A075N0I4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UPF0056 membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NTE_02959</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cell membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the UPF0056 (MarC) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N0I4"/>
    <dbReference type="STRING" id="1459636.NTE_02959"/>
    <dbReference type="KEGG" id="nev:NTE_02959"/>
    <dbReference type="eggNOG" id="arCOG01997">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079909_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002771">
        <property type="entry name" value="Multi_antbiot-R_MarC"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00427">
        <property type="entry name" value="NAAT family transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33508">
        <property type="entry name" value="UPF0056 MEMBRANE PROTEIN YHCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33508:SF1">
        <property type="entry name" value="UPF0056 MEMBRANE PROTEIN YHCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01914">
        <property type="entry name" value="MarC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF84994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="212" mass="22664" checksum="83FDFEF0B9530EDD" modified="2014-10-29" version="1">MILCCFYQMVEFLYSPEHFLQDLVRSTITLLVVIDPIGIVPIFMSLTRQMEKAGRAEVSKTVVITAAGLLFVFALAGTQIFGIFGISISSFMVAGGVLLFILAIELLTGGWRFIGSDTTGDTGVVPLAFPLLAGPGAITAVIISLETTGLVATVLSIVFAIAATYATLRYSDRIYRILGRRGSLIVTRVFAVFVAAIAIQYVVEGAKALFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N0I8</accession>
    <name>A0A075N0I8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Archaeal flagellin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_02964</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701473.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N0I8"/>
    <dbReference type="STRING" id="1459636.NTE_02964"/>
    <dbReference type="GeneID" id="41598635"/>
    <dbReference type="KEGG" id="nev:NTE_02964"/>
    <dbReference type="eggNOG" id="arCOG02926">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_184935_0_0_2"/>
    <dbReference type="OrthoDB" id="374564at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="19"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF84999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="94" mass="10144" checksum="D20343BFA21DBE51" modified="2014-10-29" version="1">MPDKEVGESQDAYQKNMKVVAVCILVMGVSIAIVVVMYLAFGHIGSTFSTGVMSNQQDKLRMQYDLPPCKPVPKSLAEVPPSLRNETGLCGSTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N0Q0</accession>
    <name>A0A075N0Q0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03014</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701518.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N0Q0"/>
    <dbReference type="STRING" id="1459636.NTE_03014"/>
    <dbReference type="GeneID" id="41598684"/>
    <dbReference type="KEGG" id="nev:NTE_03014"/>
    <dbReference type="eggNOG" id="arCOG01720">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_684461_0_0_2"/>
    <dbReference type="OrthoDB" id="11002at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="406" mass="43713" checksum="B33F5E8828501A56" modified="2014-10-29" version="1">MAGARFAVYAVAAVAASLALIAVSLSVVPALTTSALSRGEEKRVVAFEQRYNYSLGQETWTARNLKMGDIPPNSSVVILNPFSADMDNFVREKIASATTADQVRKFWARTEPYSHYNLVRLPAWLGGQKDDVSSLRAYSAVAISSGCLIKYFGNDGRWAIEDPCHSDRYRPWDGLAFAGAASMGMTSPSVPSSAGPLALATLDLSVDKDGYITAKKPDISANGSPGQGRRLSQDELTLSNREMLDAASRNAGYALPFPAAGTYGKHLLTITPAQVQWGMRVTGDLRAFEALYADYYLGSNYHRTEIAVCPVALCPDLALGDSPADLAKNMVNVAPAEDRRVESGPDIAGRYAVLIANEGLDPGYAEAKLWGKGADRTDLFVTIRAYDMTMDELTLFAKSLGLSPED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N1D3</accession>
    <name>A0A075N1D3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701710.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N1D3"/>
    <dbReference type="STRING" id="1459636.NTE_03250"/>
    <dbReference type="GeneID" id="41598905"/>
    <dbReference type="KEGG" id="nev:NTE_03250"/>
    <dbReference type="HOGENOM" id="CLU_583441_0_0_2"/>
    <dbReference type="OrthoDB" id="384198at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="468" mass="51542" checksum="B3FE0DB70E3C8987" modified="2014-10-29" version="1">MASALATSAIVICGVVVAIVLFQIYTGAEKSSAATIGYNGVEYDDMVARNVYVSVARTTETIPDRNCFGVTSRNMDEFPHGLARSIAQADNNYADEKQEVQGNQQKTTSSSDVEGVSNDQAIALLQKYHFNATVETTRQNFQRISDNAYTFECYFGYGDGGQYLMRVFFDTYYPRYVRFVTVNFTASNGGSPAISSPNIVVSSGDVNATVLFVNKLGSAVRLVYEDPSLLLSSSNGKTEPRTSEKTIPAGKMFQVNYGRYSPQDKEDNNNDVDNPHNNRTFTYTVEPYGISGTVSYRPHPSCIDSISSAKSYYAPDGALLKFPAYVPDGYSFACGVHASNYSFIATYANDRLRAKFQDREGAFSDKFLVDGGIRISYNNFLIFSGWDESLLTYDKSKVPEEWANVTGVTIDNINGNPVILGSRAATNSYGQEVGGKINTLQIFMDTEKYYIQSSLPHNELLKMAKSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N1G8</accession>
    <name>A0A075N1G8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Zn-dependent hydrolase of beta-lactamase fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N1G8"/>
    <dbReference type="STRING" id="1459636.NTE_03285"/>
    <dbReference type="KEGG" id="nev:NTE_03285"/>
    <dbReference type="eggNOG" id="arCOG00499">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_711005_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="1">
        <location>
            <begin position="60"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="417" mass="45496" checksum="3541C7FD6F2AA0AC" modified="2014-10-29" version="1">MYDAVLFALMMNNSNSGNATFFVRINGVLPDTNNGATTAAGEGKEAHTSISVFSDGFHLLVDAGGGVADSVKKGASDLGYKEEPDAILVTHGRREHTIDLASFSKSKIFCTSECAGQIAKESPQIDKSRFANIVPGQPFEAGPFSIVPVAADNAGDSPGFPGSVIYVIRAGDRKVIAGWDFLSLQNASADLMWNPDLVVLGTETYNDHPSTGMISVTQAYHTVKTWNAKDCYVLHYSGEKDKEDAKNQWHRGPAGPLPPDELQKTIDDYLRMSGLDGKISIKVARQAMVWRPAATVAAESVTEDDNSPVGNKIEIEALEKYVFGIEKRPDNKLMFVLEDSISRQENEFVNPRRKSSDSLHADPIKSMMMKGPELDLVVSGTTVKTSIIKGKKPMFAGDIRVSERDAKKLSRYIQENF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N1P6</accession>
    <name>A0A075N1P6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD-specific glutamate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03356</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N1P6"/>
    <dbReference type="STRING" id="1459636.NTE_03356"/>
    <dbReference type="KEGG" id="nev:NTE_03356"/>
    <dbReference type="eggNOG" id="arCOG08255">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1313077_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020378">
        <property type="entry name" value="DUF4186"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13811">
        <property type="entry name" value="DUF4186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="209" mass="24379" checksum="317F1D1CF00A6A61" modified="2014-10-29" version="1">MHKEEVPDWQNTKPLGRLTCTSSDCKRGLHSFIHDFRGKKLDDAISYRSQTCVDCGKQLIDWDRLDSHNIDDADYTTSMLRMEAFRLGYWERDIERKIVESAKKKGLGMLRQEAENRLRKYVNKCSNENPWDGRQTPLEGNIIYYSQHATATCCRKCIEAWHGINRNHPLSDEEIQYLVGLMMYYVEKKLPALAVEASDDINAKEKDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N296</accession>
    <name>A0A075N296_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_03536</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701938.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N296"/>
    <dbReference type="STRING" id="1459636.NTE_03536"/>
    <dbReference type="GeneID" id="41599154"/>
    <dbReference type="KEGG" id="nev:NTE_03536"/>
    <dbReference type="eggNOG" id="arCOG01586">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_907939_0_0_2"/>
    <dbReference type="OrthoDB" id="6995at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043200">
        <property type="term" value="P:response to amino acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30154">
        <property type="entry name" value="LEUCINE-RESPONSIVE REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30154:SF34">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR AZLB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13412">
        <property type="entry name" value="HTH_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="6"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF85564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="320" mass="36131" checksum="DAD0FED49E9884F0" modified="2014-10-29" version="1">MERLTLDKTDLDILAILGRDCRTSYNSMGSQIGLTSKSVKARVKNMVRNGVIEKFVVRVNPAAFGCKTAHILARTNNGITKDDVVRRVRQFGDLTYHVHQMGRNSGAGLVIKDESWNHGTIQSLKDCLKPATISNIAVTHVPVSMEPSETDLRIIKCLLQSGARMEISEIARELGISEKTATRRLDRMKEERLLDFTLQCDPAAMIGYVQFCIIMFVAKSHYRSVYERMYSEFQQSILYRPSVVDPDDRLIFVLFGENAVRVDSVLARVDSFEGVKTADAFIVTKLQYYDDWIIREIDKRLSSSSPLSRKSIKIADALNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075ML56</accession>
    <name>A0A075ML56_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dinucleotide-utilizing enzyme possibly involved in molybdopterin or thiamin biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_00077</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HesA/MoeB/ThiF family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699215.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075ML56"/>
    <dbReference type="STRING" id="1459636.NTE_00077"/>
    <dbReference type="GeneID" id="41596025"/>
    <dbReference type="KEGG" id="nev:NTE_00077"/>
    <dbReference type="eggNOG" id="arCOG00536">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG01676">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013325_5_1_2"/>
    <dbReference type="OrthoDB" id="7915at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00757">
        <property type="entry name" value="ThiF_MoeB_HesA_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000080">
        <property type="entry name" value="Thiazole biosynthesis adenylyltransferase ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF102">
        <property type="entry name" value="ADENYLYLTRANSFERASE AND SULFURTRANSFERASE MOCS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="MoaD/ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="2">
        <location>
            <begin position="103"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF82161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="444" mass="48041" checksum="D554B10F26D3AAE4" modified="2014-10-29" version="1">MAKVEFTVPSVLNKGQGEKKLPIEAADLQDAFNKVSEQMGDDFKRRVFDHNGKPRSLINIYVNGKNMRFSGGMTTALKDGDNVYILPAVAGGAELTSEELQRYSRQVMLEEIGFEGMEKLRAAKVCVVGAGGIGNPVLTQLVGMGVGKIRVVDRDVIEVTNLHRQHLYTDEDIGRVKVEAAADRLRKMNPNVEIEPVPTSVTKYTAESIVKGFDIVIDALDSIDARYALNDACIKLNIPLIYAGAIGVTGSVCTILPNKSACIRCRFPELNEEEMPACSTEGVHPSILYLVAGVEVSEAVKIIIGKEPSLVNTLLIMDLEGPSFERFQIARAEECPACGTTRTISGQQQVTAKELIIEELCGRDRGKRTWTITPANPVPVNLGGISKTAETLGYQVRTRGTLGITATNASKMSVSFLSSGAATIVGAKDEEEAVTVYNNFIKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLD5</accession>
    <name>A0A075MLD5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF2795 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00144</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987092.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLD5"/>
    <dbReference type="STRING" id="1459636.NTE_00144"/>
    <dbReference type="GeneID" id="68225745"/>
    <dbReference type="KEGG" id="nev:NTE_00144"/>
    <dbReference type="eggNOG" id="arCOG03593">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045837_0_1_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021527">
        <property type="entry name" value="DUF2795"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34776">
        <property type="entry name" value="F17F16.3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34776:SF1">
        <property type="entry name" value="F17F16.3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11387">
        <property type="entry name" value="DUF2795"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="358" mass="40307" checksum="EBE71CBCCDE286FF" modified="2014-10-29" version="1">MAEKEKPGIVEQGDIFFFYRPKVGKEEVEEIKDVQRFYMVTSPEEGKQRRLFILGQKQLPKIVEGKSTSEERNWALNVLTTSNTEDIRKELLPAEYETETRGKRRVGPATPAGEGKYSIVKHDNHTELAYVLELPPVPGPTQKEFEIKKEASYIISVKNPDIQVPGFKAFEERKPQYPSSVKEKFGDRRWINVEDPDLLNYENTQVLLIGARKRDVEEELGIDLNEEKETTNTAELFNELKIRKDQVPLKPLLKGDFPGKEEMPSEREVQQLSSEEAPGRGGKAGGRAAASRAPSAAAIAKILAGTDFPKKKDELVRVAEKNAGRVESAQDIVQTVRDLPDRKYNSMADVEKALGKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLD8</accession>
    <name>A0A075MLD8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00149</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699267.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLD8"/>
    <dbReference type="GeneID" id="41596088"/>
    <dbReference type="KEGG" id="nev:NTE_00149"/>
    <dbReference type="HOGENOM" id="CLU_1056086_0_0_2"/>
    <dbReference type="OrthoDB" id="11913at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="277" mass="28189" checksum="E551E5F01A1113BF" modified="2014-10-29" version="1">MNDKAKVFSAAIAAVLVSAIVAGSFSVAKSYAQNPIQDLIGNATKAGKSLVGNVTGSGNQTSTTGNQTGNQTATTGNQTGTAPTGNQTGLKMQDGRLTGRIASIQQEANKPAWILAGIWKLEEVKSNATAATGGNATVTAGNATVTTQGNATVTTDGNKTTVTGNATSMTGQNNTSTSAGSNLSFVAKIEMVRPDGTAPHEHEVSDLKVTQIKNDESGNPTINGTVTVTMSKGPVQDVPVTIKIIGNSAIAMTLGPDKIDNHFGTEPIYGTVAKERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MLF7</accession>
    <name>A0A075MLF7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MEDS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00194</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699297.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MLF7"/>
    <dbReference type="STRING" id="1459636.NTE_00194"/>
    <dbReference type="GeneID" id="41596119"/>
    <dbReference type="KEGG" id="nev:NTE_00194"/>
    <dbReference type="HOGENOM" id="CLU_1418635_0_0_2"/>
    <dbReference type="OrthoDB" id="12057at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="184" mass="20754" checksum="A730C12AAC0CB917" modified="2014-10-29" version="1">MSQELDSLDKTGHVLLLYDSELEREYTISEFIHNTLGRGHTAVLASISNDTFAQSSKYQTITASHDGKSERGCFILLDIRDCYEDALNGDFHGASKMREKLERILTEQSSDNDFVIIVVDCAEHLSLNEKFEECGILEKSLQNSFKSWERRGLKVLLICPHLASVLDAGEKKMLEKNHTAIAMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MM26</accession>
    <name>A0A075MM26_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00459</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MM26"/>
    <dbReference type="KEGG" id="nev:NTE_00459"/>
    <dbReference type="HOGENOM" id="CLU_1418634_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="191" mass="21439" checksum="FE7963F0E7CAE07F" modified="2014-10-29" version="1">MGQLYRVTTATNQVVQLLKDDSFSVDVITRILSILSDEGDMKRTVLAGRARLNYSALIRYLRLLKTLRWIDSKDSDSSIIAITNVGRSFNKLLEQTGGGPSDTSEEALERLLAFSREQNLAEGNLGKHLPKNAVTKAKTMTGSRSCSFCGNTLGSHEVTREIDGERYSFDRRECAILFMRFRDAYGKEFTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMF5</accession>
    <name>A0A075MMF5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">NTE_00233</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699325.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMF5"/>
    <dbReference type="STRING" id="1459636.NTE_00233"/>
    <dbReference type="GeneID" id="41596151"/>
    <dbReference type="KEGG" id="nev:NTE_00233"/>
    <dbReference type="eggNOG" id="arCOG02358">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG03644">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031353_0_0_2"/>
    <dbReference type="OrthoDB" id="8127at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00075">
        <property type="entry name" value="HATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18773">
        <property type="entry name" value="PDC1_HK_sensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033479">
        <property type="entry name" value="dCache_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050736">
        <property type="entry name" value="Sensor_HK_Regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43711:SF1">
        <property type="entry name" value="HISTIDINE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43711">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02743">
        <property type="entry name" value="dCache_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="371"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="15">
        <location>
            <begin position="443"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="470"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="395"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="470"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AIF82315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="698" mass="77119" checksum="2A2C5C4D3876CB0F" modified="2014-10-29" version="1">MNDPVRKRETEEYGGAAHRMTEDGASGQDRKDYALPSSSKRKKTFFLVVLVAATAIILGIVSYKYYQYTIDRIAELAKDEIQYNTQVQSAAISRMLGKDIQKVEGNLQTLTLSPVVFGNEVARFPAIFGSRQDLTEDLTDFYILADRNGKIEWISFGDNSSGVSLAKNAASTTLSNNNNATALKIIGSDVSMEEWYAETKKTLRPYQSPPIITPFDNVRRLYISYPLVDDNGVFQGVVAAGIPLDKVDRVLQSDLFPRYQSRVAMIDRNGIVLSSDDPERIGTSVFSDTFKERVSPTLAKGEPQLLDDFFRKSVSGQPATVQLTFSGVKAVFTGYPIFADNSSQNHFGTITVRTYYALATNVEGILGEQRIFGLAAPAIIGGVASAVIVLLLSWNKNLEKAVDKKTIELKESNELLQKKTRQLEAANEQLRLHDKMQTEFINIAAHELRTPIQPMMGVVDLLKERLMLRNSNSNSNSNSNSSNNDHPESVAISSKHLAILERNAKRLQKLSTEILDATRIEAGTLKLDREIMDINQKVRNVIADTKSWIPKDANIDIQFKPAVKEDAEGNPAPLLVNIDRLRMFEVISNLIRNAIKFSDNNNDSSSGADGTPKIVTITTEKKGNEVVVSVKDQGAGISADIFPRLFTRFSADRERGGTGLGLFIAKNIVEAHGGRIWAENNNKDGERGATFAFTLPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MMV3</accession>
    <name>A0A075MMV3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00522</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MMV3"/>
    <dbReference type="STRING" id="1459636.NTE_00522"/>
    <dbReference type="KEGG" id="nev:NTE_00522"/>
    <dbReference type="HOGENOM" id="CLU_2968582_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="58" mass="6564" checksum="48BF0389A04F2516" modified="2014-10-29" version="1">MPMLMLKCKSCGEVFPGIYVPEGSTDNFKSIATSSDPLHICSRGHKNMYLTEDYMDWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MN66</accession>
    <name>A0A075MN66_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative signal-transduction protein containing cAMP-binding and CBS domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_00900</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699838.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MN66"/>
    <dbReference type="STRING" id="1459636.NTE_00900"/>
    <dbReference type="GeneID" id="41596739"/>
    <dbReference type="KEGG" id="nev:NTE_00900"/>
    <dbReference type="eggNOG" id="arCOG00606">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040681_12_2_2"/>
    <dbReference type="OrthoDB" id="43333at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051257">
        <property type="entry name" value="Diverse_CBS-Domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43080:SF2">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43080">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN CBSX3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="8"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="3">
        <location>
            <begin position="75"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF82976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="145" mass="15746" checksum="ADBF768CB1E18D2D" modified="2014-10-29" version="1">MSAVSEIMSSKIVTVDADSDPSVLDVVEAMVKHKEGAIIILEKRRPVGIITERDVLKKVSAQNKKPKEISAKSIMSSPLITVKAYDSVDTAAQAMTKNKIKRLPVVETGGSLVGMMSATDITRRLAKILADDYSRYRSLGDALEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MN71</accession>
    <name>A0A075MN71_9ARCH</name>
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        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">NTE_00519</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MN71"/>
    <dbReference type="KEGG" id="nev:NTE_00519"/>
    <dbReference type="HOGENOM" id="CLU_3227628_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="43" mass="5202" checksum="9F8708A5A1466A3D" modified="2014-10-29" version="1">MMRTEKNKGNIITKMNLLFAHLAFKGYSFTFSKYILDYNKLFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MN81</accession>
    <name>A0A075MN81_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
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            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MN81"/>
    <dbReference type="KEGG" id="nev:NTE_00175"/>
    <dbReference type="HOGENOM" id="CLU_2257224_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="103" mass="11687" checksum="699C47EA930226F0" modified="2014-10-29" version="1">MSLARRMFLGIALASAVIIIMPTAVFSAAAENVDDNNKMTATMYIDGSSDCWKWVRYPHGFGEWQQFKTFSPCESYECHLPRYELDEVCHNVLGEKRMKATTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNQ0</accession>
    <name>A0A075MNQ0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
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            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
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    </dbReference>
    <dbReference type="RefSeq" id="WP_148699731.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNQ0"/>
    <dbReference type="STRING" id="1459636.NTE_00760"/>
    <dbReference type="GeneID" id="41596611"/>
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    <dbReference type="HOGENOM" id="CLU_2056128_0_0_2"/>
    <dbReference type="OrthoDB" id="10186at2157"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="124" mass="13030" checksum="EAC01F6E1E3D5E99" modified="2014-10-29" version="1">MRVSAVAIVLAAIAVTGAIAIPSGNPAFLDRAIALECVFIALAVLTFAGYKKQLYACIPLAVIVMVGNSLAPPHVEIMTTFSKPLNAIVLITGGYILQIALIATAVLELQKRRKVATASSQKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MNX9</accession>
    <name>A0A075MNX9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00435</name>
    </gene>
    <organism evidence="1 2">
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        <lineage>
            <taxon>Archaea</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158384980.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MNX9"/>
    <dbReference type="STRING" id="1459636.NTE_00435"/>
    <dbReference type="GeneID" id="43502560"/>
    <dbReference type="KEGG" id="nev:NTE_00435"/>
    <dbReference type="HOGENOM" id="CLU_3093923_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="51" mass="5420" checksum="62B0C8DDC4ADAAF9" modified="2014-10-29" version="1">MKTSASLAKLNGLKTADIDTAASFIVQEDPGYPAIEKYVDGGYTLARLGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MP03</accession>
    <name>A0A075MP03_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00807</name>
    </gene>
    <organism evidence="2 3">
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        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MP03"/>
    <dbReference type="KEGG" id="nev:NTE_00807"/>
    <dbReference type="HOGENOM" id="CLU_3075491_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="53" mass="6208" checksum="830700ECAF5A70A1" modified="2014-10-29" version="1">MLENLAYPIMGFAFTYLALETAWHFAVCRIHDPKLQPCVFKEVKMLVAHNRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MP47</accession>
    <name>A0A075MP47_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
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            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699519.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MP47"/>
    <dbReference type="STRING" id="1459636.NTE_00491"/>
    <dbReference type="GeneID" id="41596364"/>
    <dbReference type="KEGG" id="nev:NTE_00491"/>
    <dbReference type="eggNOG" id="arCOG10307">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003211_0_0_2"/>
    <dbReference type="OrthoDB" id="148404at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011749">
        <property type="entry name" value="CHP02243"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02243">
        <property type="entry name" value="putative baseplate assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="956" mass="104179" checksum="036C660786769998" modified="2014-10-29" version="1">MEGNCCSCGHSTNCGCPERKKYTPARIYNPAGQSSLSYRVGTHAQFKADMVSSIASQTRLQALKTRDDSDLSIAILDSWALVADVLSFYQERIANEGFLRTATERRSVLELARSIGYELGPGVAASAHLAFSMETSPGSPRRAKIPSGSKVQSIPAQDELPQTFETMEDIEARKEWNAILPRQVKKQDLKTALKEGRVVLEGTSTLVRVGDGLLFVISKAGKAEAAFVIAREVLVDAPKRQTVVLFDTAGAGFEPVKNPPPAKGDSATKPDDSVIDSETHFTYGDLRSLISFQSLEESELQALATLKGWSVDKVVDAVNSERESDTSASGSVYAFRVKCGVFGNSAPLWSSLPPEMRFDYTDPTKRFPNKIEAPYPHDWDTYPVPVNRSSRKKMKASRRDMSDLAFYNENGHLIYLDNVYPSVKKESWVILANPSRVSAYYVAETADASLAEFAQSAKATGTLLDDTLANLKVTKKDEKGHKTKHIASKDPIVDDLGYFFFRDTVVYCAPEKVELADVAVTGDIQDSQNAVILDGMVGNLVADRPVIVSGELAQQPGVMGREVATVSKIVHFDRVSMLTTMYLSKLQYSYRRETVTINANVALATHGETKQVPIGSGDPAQRFQAFELSDSPLTFVPAANASGAASTLKVVIDGVEWEEKESFENLDHRDKAFVTRRSDGGKTTVIFGDGVTGRLPPAGAENIQATYRVGIGMKGLLKADQLSQLLTRPLGVSKVTNPLATSGAGDPEKLDDARKNAPRTVLTMDRIVSLEDYKNFAQGFQGIGKAGSYPIRIGNDNVVLVAVATASGAELKKTDNLYSKLEQAIENYKDPASRFILSSFKARLFDVDARIKVSSDRKFEDVQAELKSALKETFSFEKRNFGQAVTLSEVVSVMQGVEGVVAVEVKSIYDHDIKEPTDVVRARDPNGVQSDGIPVPVLLLINADGISLDKMEASPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPB3</accession>
    <name>A0A075MPB3_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF2024 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01318</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700167.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPB3"/>
    <dbReference type="STRING" id="1459636.NTE_01318"/>
    <dbReference type="GeneID" id="41597120"/>
    <dbReference type="KEGG" id="nev:NTE_01318"/>
    <dbReference type="eggNOG" id="arCOG08720">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_188388_0_0_2"/>
    <dbReference type="OrthoDB" id="5685at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.510.10">
        <property type="entry name" value="NE1680-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018592">
        <property type="entry name" value="DUF2024"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023122">
        <property type="entry name" value="NE1680-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09630">
        <property type="entry name" value="DUF2024"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160766">
        <property type="entry name" value="NE1680-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="87" mass="10000" checksum="30429F88FE1C56D2" modified="2014-10-29" version="1">MECAVYDTYVQKKDGKIMHFDVVVEANTPHEKAIQYGQEWLSTVGQAGQKMTSEECQFCHIQEAPPFVEKSIKQQGYWIQKMEGCPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPB9</accession>
    <name>A0A075MPB9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nitroreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NTE_01328</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nitroreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700174.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPB9"/>
    <dbReference type="STRING" id="1459636.NTE_01328"/>
    <dbReference type="GeneID" id="41597127"/>
    <dbReference type="KEGG" id="nev:NTE_01328"/>
    <dbReference type="eggNOG" id="arCOG00288">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070764_7_1_2"/>
    <dbReference type="OrthoDB" id="287850at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02062">
        <property type="entry name" value="Nitro_FMN_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="entry name" value="NADH Oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43673">
        <property type="entry name" value="NAD(P)H NITROREDUCTASE YDGI-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43673:SF2">
        <property type="entry name" value="NITROREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="FMN-dependent nitroreductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="6">
        <location>
            <begin position="50"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Nitroreductase" evidence="6">
        <location>
            <begin position="111"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF83396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="210" mass="23326" checksum="E229596DE2FCAADE" modified="2014-10-29" version="1">MSSSYPSDVFSRLYAGEESDKLYPKEEAAEQAPEGVEDVLQTNIFNVMLNRRSQRKFEDRPVEDSKMEMIFAAADTAPTAGGFQGFEIFNVKKADVKAKLVEAANKQPYVNAPEVLVFCMNPQRVKLNFPPEIIRKFSVQDATLAAAYAQLAAHALGLSTVWIGMIDEKKVMSALGTDLVPSSILCIGYPQKMLQPKPKRNLVELIHTVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPC8</accession>
    <name>A0A075MPC8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00993</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699907.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPC8"/>
    <dbReference type="STRING" id="1459636.NTE_00993"/>
    <dbReference type="GeneID" id="41596821"/>
    <dbReference type="KEGG" id="nev:NTE_00993"/>
    <dbReference type="eggNOG" id="arCOG08825">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_775269_0_0_2"/>
    <dbReference type="OrthoDB" id="10528at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="324"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="359" mass="39217" checksum="93659DCE01E98C27" modified="2014-10-29" version="1">MRRYAFALAAVVTAAAATLFAATVFASAQNAYAHFEHFGHYNAKGDAIGPYYAYEQLDPDYAKPGEPAAIQFSIQDHDGRDTKDLVTMVEVYSGITGERLAAFPWTKQDTGDFQLFYTFPDVGYYQIVLSMATGPANNLNGVDPPRTTLSGTAGCNCDRAVFNAAISNNFGEIWSTAMIASVLIPLGIIGVVLGLVYKRKRKELHANSSEEFVKWSLLLLAIAGGMVHFAIYSEHASLRLEYSIFLITAGIAQVSYGLMYILLTMVGAEESRINPRRYYRKTVVLNLFGLIGTAVLLGLYAYAITFPPPLSPNPVPEDVDLAGILAKSAEAILVVGIIYLMRLEKRRLASRLAETPSKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPF7</accession>
    <name>A0A075MPF7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Arabinose efflux permease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NTE_00949</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699877.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPF7"/>
    <dbReference type="STRING" id="1459636.NTE_00949"/>
    <dbReference type="GeneID" id="41596784"/>
    <dbReference type="KEGG" id="nev:NTE_00949"/>
    <dbReference type="eggNOG" id="arCOG00144">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_34_0_2"/>
    <dbReference type="OrthoDB" id="117970at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17504">
        <property type="entry name" value="MFS_MMR_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF192">
        <property type="entry name" value="TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
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        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
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        <location>
            <begin position="53"/>
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        </location>
    </feature>
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        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
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        <location>
            <begin position="252"/>
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        <location>
            <begin position="294"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="338"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="423"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="465"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="19"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AIF83025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="497" mass="52803" checksum="F981A4A36B5A75CE" modified="2014-10-29" version="1">MEKEKSQNPDKIPLSAWKTLAILSSIATMVMYVETMLVPSLPHIMREFSLPYSISPWILTTYLIAGAVMTPIASSLANLHGKKKVLMCIMLVYAAGVVVGGITNDFYSFIVARGMQGVGMAMFPLAFSIIREQFPRSRLAIGQGIITSMFASGSILGLLVGAGIAEAFGWRMTFLSIVPITGLLLFVIMRSIREGQVHPQWRQQQQGSAEQAGPKPSLDVYGAIALAIVITSFLLLLTYIRPDAGAGGNSSSSMPTLLAISGVCAASLAAFVLIERKATNPVVDYRLFKNKTLLFGNVMIVVIGFSMFMVFQTIPILAESPKPIGFGANVTEAATIQLPFAVILLIFGPTSGFIVSKMGSIRPAIIGSAVNVLGFVLLATFHSIPWMVSISLAIISTGLSLGSVGIMNIILLSTPQRQMVSSLGNTTLFRIIGSSVGPAVAGVLMQTHLVAADGVSGTFPAPETYTMIFVGAAVMAVLSVVISVLLRKELPVSLRAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPQ3</accession>
    <name>A0A075MPQ3_9ARCH</name>
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        <submittedName>
            <fullName evidence="10">Large conductance mechanosensitive channel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NTE_01477</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPQ3"/>
    <dbReference type="STRING" id="1459636.NTE_01477"/>
    <dbReference type="GeneID" id="41597269"/>
    <dbReference type="KEGG" id="nev:NTE_01477"/>
    <dbReference type="eggNOG" id="arCOG05213">
        <property type="taxonomic scope" value="Archaea"/>
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    <dbReference type="OrthoDB" id="137361at2157"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive monoatomic ion channel activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.120">
        <property type="entry name" value="Large-conductance mechanosensitive channel, MscL, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001185">
        <property type="entry name" value="MS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037673">
        <property type="entry name" value="MSC/AndL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036019">
        <property type="entry name" value="MscL_channel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00220">
        <property type="entry name" value="mscL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30266:SF2">
        <property type="entry name" value="LARGE-CONDUCTANCE MECHANOSENSITIVE CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30266">
        <property type="entry name" value="MECHANOSENSITIVE CHANNEL MSCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01741">
        <property type="entry name" value="MscL"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF81330">
        <property type="entry name" value="Gated mechanosensitive channel"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0407">Ion channel</keyword>
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    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIF83541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="130" mass="13928" checksum="60C0E92FB0965638" modified="2014-10-29" version="1">MSDSNSSAAPPPEKKSLMTEFIIFLRTFGVIGLAIAFVIGAAASKLVTAFVNDIVTPIVGLALPSGDLKTMAYNVTNSVTGATTTFSYGDLISNIIDFLIIAFIVFLMYKLLSRYKVFGVEDKTKPAPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPS6</accession>
    <name>A0A075MPS6_9ARCH</name>
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        <submittedName>
            <fullName evidence="5">ATPase component of various ABC-type transport systems with duplicated ATPase domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_00774</name>
    </gene>
    <organism evidence="5 6">
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        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
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            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148702005.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPS6"/>
    <dbReference type="STRING" id="1459636.NTE_00774"/>
    <dbReference type="GeneID" id="41596625"/>
    <dbReference type="KEGG" id="nev:NTE_00774"/>
    <dbReference type="eggNOG" id="arCOG00184">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_2"/>
    <dbReference type="OrthoDB" id="18209at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03257">
        <property type="entry name" value="ABC_NikE_OppD_transporters"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050319">
        <property type="entry name" value="ABC_transp_ATP-bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43776:SF8">
        <property type="entry name" value="ABC TRANSPORTER, ATP-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43776">
        <property type="entry name" value="TRANSPORT ATP-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF82852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="277" mass="31038" checksum="6F561CFF8DD8C34D" modified="2014-10-29" version="1">MAAPLLEVRDLRKYFAVKRSFRQMLHQKGRDFVKAVDGVSFTLERGKVLVLAGESGSGKTTVARLVLRATDPDAGSIIFEGNDVTLYTGSQLKHFRSSVHMVYQDPYASLNPRMKIMDIVMEPLSIHDRASTKEQKEEKVLKALEEVRLVPAQEIARRLPHMLSGGQRQRVALARALVMRPALIVADEPVSMLDVSVRGEILDLMQTLRRRFSLSYIYITHDLSTARYVGDDIAIMNAGKIVETGPIDRVLLSPAHQYTKSLIEAIPDPDRGRTYAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPT0</accession>
    <name>A0A075MPT0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_01135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPT0"/>
    <dbReference type="KEGG" id="nev:NTE_01135"/>
    <dbReference type="eggNOG" id="arCOG08661">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075307_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038762">
        <property type="entry name" value="ABM_predict"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40057">
        <property type="entry name" value="SLR1162 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40057:SF1">
        <property type="entry name" value="SLR1162 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="ABM" evidence="2">
        <location>
            <begin position="17"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF83208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="189" mass="21867" checksum="4F5CF7EF0BA0E8AE" modified="2014-10-29" version="1">MFMANVSKGVTRIYSRNIKPGHEQQYDDWLRRYLTYERQARGYLGTTVIVPGGTNSNLRYIIHHFANSDSLDEWERSEQAIKMLEEVNNYSTRHYETATGLETWFTVPDLHAVAAPPKWKMAVIVFAAAFAISTSARYLLNHYLESTSLFISNVVYTAILVLLLTYLAMPALSRLLRKWLYSKKENEYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MPW8</accession>
    <name>A0A075MPW8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Isocitrate dehydrogenase (NADP)</fullName>
            <ecNumber evidence="8">1.1.1.42</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NTE_01097</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.42" evidence="8"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699986.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MPW8"/>
    <dbReference type="STRING" id="1459636.NTE_01097"/>
    <dbReference type="GeneID" id="41596913"/>
    <dbReference type="KEGG" id="nev:NTE_01097"/>
    <dbReference type="eggNOG" id="arCOG01163">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031953_0_1_2"/>
    <dbReference type="OrthoDB" id="6813at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004449">
        <property type="term" value="F:isocitrate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004450">
        <property type="term" value="F:isocitrate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019298">
        <property type="term" value="P:coenzyme B biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000019">
        <property type="entry name" value="Homoisocitrate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF77">
        <property type="entry name" value="ISOCITRATE_ISOPROPYLMALATE DEHYDROGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="7">
        <location>
            <begin position="6"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF83170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="342" mass="37797" checksum="B59668A7375ADF5E" modified="2014-10-29" version="1">MAKKTTAAIIRGDGTGPELVNAMVKVLKACNTKIELVQCDAGSEWWEKNGGNSYISPEVWKLLEDSDACFKGPTTTVPVPNAPRSVAVSIRQKFQLYGNLRPIKTYANAEKQLDFICVREATEGLYAGIEFKTSDDSAIAIRKTTRKGCDRIARKAFEVAKDYGWKKVVAITKRNILKETDGIFWSSIENAAKDFKGIEYEEYYIDNMTQQLVKNPERFNKNVLVSTNLFMDVISECASGNVGSIGNVYSGNYGDDYAMFEPAHGSAPKYAGKDKVNPVATVLSGAWMADYLGEREICKAIFKATEDVINENKYVTYDLGGTASLSKMADQIATRSAKLLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQ08</accession>
    <name>A0A075MQ08_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF72 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00871</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699813.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQ08"/>
    <dbReference type="STRING" id="1459636.NTE_00871"/>
    <dbReference type="GeneID" id="41596713"/>
    <dbReference type="KEGG" id="nev:NTE_00871"/>
    <dbReference type="eggNOG" id="arCOG04291">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046519_3_1_2"/>
    <dbReference type="OrthoDB" id="35747at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.410">
        <property type="entry name" value="Protein of unknown function UPF0759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002763">
        <property type="entry name" value="DUF72"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036520">
        <property type="entry name" value="UPF0759_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30348:SF4">
        <property type="entry name" value="DUF72 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30348">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YECE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01904">
        <property type="entry name" value="DUF72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117396">
        <property type="entry name" value="TM1631-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="271" mass="31793" checksum="63F49F82D1B4DC52" modified="2014-10-29" version="1">MLLGTCGWSYQEWVGLFYPNNRVAKLPFYAKVFDTVEVDSSFYRMPTKMMVRGWEKATGPLFKFSLKLPKTITHDKRLTEGAEDDLAKFLDVIKPLEESDKLGCLLVQLAPSFSYDEADVLESFLELLPSYIHFAVEFRHESWDRKETWDLLKKYNVANTITESPIEFLSKIVVTSSTHAYVRWHGRGKPIWYDYTYSEEELMPWVDKLKEMEAKVPVTYAYFNNHYNAGAPHNALQFLAMRGELDEMQEKTITRIERKIRRKPSRITDFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQ50</accession>
    <name>A0A075MQ50_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00926</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQ50"/>
    <dbReference type="STRING" id="1459636.NTE_00926"/>
    <dbReference type="KEGG" id="nev:NTE_00926"/>
    <dbReference type="HOGENOM" id="CLU_145173_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="141" mass="16585" checksum="3A4FB7479BEFB735" modified="2014-10-29" version="1">MRRAIRELSSDEGKSHKSENLFKIIDGIIFELNRTKRLFIVMVLTGMIVPPLTFLIVNALTEPFMPGPGGFREIHQERVFLRQLPWIVSIVWLGIGIRQWLVLSKWTKKYDRYKKLQEEIDKKFDEDEPANNNNNNSSNNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQK6</accession>
    <name>A0A075MQK6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription factor Pcc1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CTAG/PCC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700518.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQK6"/>
    <dbReference type="STRING" id="1459636.NTE_01755"/>
    <dbReference type="GeneID" id="41597525"/>
    <dbReference type="KEGG" id="nev:NTE_01755"/>
    <dbReference type="eggNOG" id="arCOG01354">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_184184_0_0_2"/>
    <dbReference type="OrthoDB" id="381817at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015419">
        <property type="entry name" value="CTAG/Pcc1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09341">
        <property type="entry name" value="Pcc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="95" mass="9997" checksum="B6B9641B8A5781BB" modified="2014-10-29" version="1">MTRNSQQHPDVPTAVDAQVSVSFPTAARARAAVKALIPDNVNMPAGLTVDIFSRGRTVLVRVGGNDGVSIATVASTLDEILEHLSVAWKVMTTNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQN2</accession>
    <name>A0A075MQN2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal RNA methyltransferase NOP2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">NTE_01459</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700281.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQN2"/>
    <dbReference type="STRING" id="1459636.NTE_01459"/>
    <dbReference type="GeneID" id="41597253"/>
    <dbReference type="KEGG" id="nev:NTE_01459"/>
    <dbReference type="eggNOG" id="arCOG00973">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005316_7_0_2"/>
    <dbReference type="OrthoDB" id="14725at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009383">
        <property type="term" value="F:rRNA (cytosine-C5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1170">
        <property type="entry name" value="Sun protein, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011023">
        <property type="entry name" value="Nop2p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054728">
        <property type="entry name" value="RsmB-like_ferredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00446">
        <property type="entry name" value="nop2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807:SF30">
        <property type="entry name" value="28S RRNA (CYTOSINE(4447)-C(5))-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22458">
        <property type="entry name" value="RsmF-B_ferredox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="5">
        <location>
            <begin position="38"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF83523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="320" mass="35330" checksum="494E02DC058BAFD8" modified="2014-10-29" version="1">MTLLFDRSARSTALADKYGYGEWLVGRFLQHVPEVERFMEKMEQPPSQYIRVNTLKTTRDDLESRLAAKGFELEPTALSEVLKVTKAPMATGATNEYLLGHYYIQDLSSCMAVEALDAQKSQSALDMAAAPGGKTTHIAQRMQNTGSIVALEPNTKRARSMSFNLDRLGVANTCILCADALCATAGLGKEKFDRVLLDAPCSCEGVIAKDKTRKTSHSPQDVDYCAGRQEKMLEAAVGACKRGGIIVYSTCSFAPEENEVIVDRMVRKFGVSVEPMLHGSEGLAHFGNMEFDKSVRNARRFYPHIHDTTGFFVARMRVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQQ3</accession>
    <name>A0A075MQQ3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01119</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700002.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQQ3"/>
    <dbReference type="STRING" id="1459636.NTE_01119"/>
    <dbReference type="GeneID" id="41596933"/>
    <dbReference type="KEGG" id="nev:NTE_01119"/>
    <dbReference type="HOGENOM" id="CLU_2010004_0_0_2"/>
    <dbReference type="OrthoDB" id="377351at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="123" mass="14585" checksum="EAECAA618D5B65E1" modified="2014-10-29" version="1">MDQIFIEPNQELIEIAKDVCAEEAIDFDSLDARQVRGLIYYWCSSCNRIYPLTNLVVSKRKNICEHCKEKVKIYSNSNKYGKLRRRIFNKILDMRKKRSTAEYASVPYDTRRIIFLPEKTGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MQW5</accession>
    <name>A0A075MQW5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01882</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700618.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MQW5"/>
    <dbReference type="STRING" id="1459636.NTE_01882"/>
    <dbReference type="GeneID" id="41597639"/>
    <dbReference type="KEGG" id="nev:NTE_01882"/>
    <dbReference type="HOGENOM" id="CLU_2103382_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="115" mass="13078" checksum="B9C93C7347AE57AB" modified="2014-10-29" version="1">MTSQETTSNGPDYSIKSTDNDIKGKSDSKGQTEIQWYGIVVACRGGKKIVFYSRWTKITVRYNKLKAVMYNSDDPRADFYQVCQDVGLIVDSTRWSEDECGVPMVECRIKEYGPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MR07</accession>
    <name>A0A075MR07_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Diphthine synthase</fullName>
            <ecNumber evidence="8">2.1.1.98</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">NTE_01580</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">SR1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the diphthine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.98" evidence="8"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700376.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MR07"/>
    <dbReference type="STRING" id="1459636.NTE_01580"/>
    <dbReference type="GeneID" id="41597360"/>
    <dbReference type="KEGG" id="nev:NTE_01580"/>
    <dbReference type="eggNOG" id="arCOG01224">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG04161">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066040_0_0_2"/>
    <dbReference type="OrthoDB" id="39139at2157"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004164">
        <property type="term" value="F:diphthine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd11647">
        <property type="entry name" value="DHP5_DphB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.90">
        <property type="entry name" value="AF1782-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="entry name" value="Cobalt-precorrin-4 Transmethylase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="entry name" value="Methyltransferase, Cobalt-precorrin-4 Transmethylase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036809">
        <property type="entry name" value="AF1782-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004551">
        <property type="entry name" value="Dphthn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023140">
        <property type="entry name" value="DUF357"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00522">
        <property type="entry name" value="dph5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10882:SF0">
        <property type="entry name" value="DIPHTHINE METHYL ESTER SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10882">
        <property type="entry name" value="DIPHTHINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04010">
        <property type="entry name" value="DUF357"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158372">
        <property type="entry name" value="AF1782-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="Tetrapyrrole methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tetrapyrrole methylase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="DUF357" evidence="7">
        <location>
            <begin position="277"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AIF83643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="358" mass="39222" checksum="14AA16A64D36A3BF" modified="2014-10-29" version="1">MLWLVGAGISGHRGLSLEAVQVLKKCDIVFVERFTSALSDSDLEGINAAIGKSAKPVQRWFVEDGREMLDAAKEKQVALVAYGDPLLATTHTELRARAAKASIETGVLHAASGITAIMGECGLHMYKFGRTVTMMSEPKSAVSVYNTVFDNLLLGSHTLILTEYSHDEKTGEPFFLDPTAVLKMLLDCERDLRHHVFSEETFVVVASRLGSSDSRIVSGRIKSLAGVGFGAGPHSVIVPAGLHFTEEEALEALTVCLDSPADNAASVKRISSQMIERYAPKAKEAVRHMRDILRKEGAKEKENNKGMHEVLDNAEYYIDDAERFLRQGKHELAVLSIGYAEGLLDALRFQKGINPWNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MR32</accession>
    <name>A0A075MR32_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700392.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MR32"/>
    <dbReference type="GeneID" id="41597378"/>
    <dbReference type="KEGG" id="nev:NTE_01600"/>
    <dbReference type="HOGENOM" id="CLU_2392995_0_0_2"/>
    <dbReference type="OrthoDB" id="6968at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="93" mass="10452" checksum="EB6E41A21ED2540F" modified="2014-10-29" version="1">MTVDLSQYLTNTLNPKVFLAPNTSDQEVVEKAKKLLVQNGLREDLIQVNYDMQQLDVGDLNVSYDPPDLVVRAVYDKKPSGIVKMKSVAMIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRA4</accession>
    <name>A0A075MRA4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4256 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02029</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRA4"/>
    <dbReference type="STRING" id="1459636.NTE_02029"/>
    <dbReference type="KEGG" id="nev:NTE_02029"/>
    <dbReference type="HOGENOM" id="CLU_2712612_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025352">
        <property type="entry name" value="DUF4256"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14066">
        <property type="entry name" value="DUF4256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="72" mass="8305" checksum="B009D3C8B77A1EE2" modified="2014-10-29" version="1">MGIELLTEEQYRELQKLGNFDTKTSSWVRTPSDIRKLGGALFADFRYGHVFVYHNGAQSYYGVRAFRGSLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRA5</accession>
    <name>A0A075MRA5_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700133.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRA5"/>
    <dbReference type="GeneID" id="41597082"/>
    <dbReference type="KEGG" id="nev:NTE_01278"/>
    <dbReference type="HOGENOM" id="CLU_2379521_0_0_2"/>
    <dbReference type="OrthoDB" id="373404at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="24"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="96" mass="11075" checksum="F36BAEC46BDB342E" modified="2014-10-29" version="1">MMATHSAAKWKLVYMLAQTYALDMLEAVSKKPMRFTDLESHSPNERTRSQRLKDLEDAGLITTISLKINKRYFVHYTATNKGRQVLQKARELADMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRD3</accession>
    <name>A0A075MRD3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_01309</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700159.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRD3"/>
    <dbReference type="STRING" id="1459636.NTE_01309"/>
    <dbReference type="GeneID" id="41597111"/>
    <dbReference type="KEGG" id="nev:NTE_01309"/>
    <dbReference type="HOGENOM" id="CLU_658252_0_0_2"/>
    <dbReference type="OrthoDB" id="386830at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF83377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="417" mass="47455" checksum="3DDA80570975FE85" modified="2014-10-29" version="1">MKKEFLVDYQAKEIAEYENYRKQIDSGIDGVVFPNTQRFANARLPLVRAETSYDLIKEKIWSQIPFAGTLLIPLFNVSKENLLDMNGFEIQDIPKLIDLSKETGRVQFVLNMTPIEYEGLDHLDPILEELKPPMLQPIPLDKFASRKTWDTWHDEFDELASRSYLKFMYQRITSNGESRAYYSALMNNHAFTYGKLKMLKMDDVVAMISDTMISDPDMASRLFFAYSLLTGPQFEALPANYNLAFLKAQLLGAQDNKSPKYPVEIGSFLMEKMTLNPSSYYGCVSVIERYKQNDLYKVLESVDKAIRDREQTKTLSDINELGIVMDNVWKDAEKIKRTDEITKAGISIGVAAIGSFATSLLGAGVGITEGALAGMGFNVADRLLEKFDSSLSNKLLKWLNKDYMINIYNFQKRLPAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRJ9</accession>
    <name>A0A075MRJ9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative threonine efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NTE_01649</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRJ9"/>
    <dbReference type="STRING" id="1459636.NTE_01649"/>
    <dbReference type="KEGG" id="nev:NTE_01649"/>
    <dbReference type="eggNOG" id="arCOG01947">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104651_0_0_2"/>
    <dbReference type="OrthoDB" id="121309at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001123">
        <property type="entry name" value="LeuE-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38825">
        <property type="entry name" value="LYSINE EXPORTER PROTEIN (LYSE/YGGA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38825:SF1">
        <property type="entry name" value="TRANSPORTER, LYSE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01810">
        <property type="entry name" value="LysE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF83710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="218" mass="23036" checksum="8C71ED13AF3D8708" modified="2014-10-29" version="1">MDVLAFGAEVVAVSASGVLAPGPLFVANMMYGTRQGALSGIKVAHGHAVVEIVVIAVIAAGLFSASAFIADYASVIAIIGGVSIIGFAILQIVGIITTARKSKQERKTETVRRKNGPFAAGVMFSALNPFFLVWWLTVGLKLVSDSAAFGAVAGPALLFGMHVWMDYVWLAATAYLASKGSSVLKSKYYRVLMLVLAGLLLYYGVQFLINGVMMIIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRM2</accession>
    <name>A0A075MRM2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pyruvoyl-dependent arginine decarboxylase</fullName>
            <shortName evidence="6">PvlArgDC</shortName>
            <ecNumber evidence="6">4.1.1.19</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="6">Pyruvoyl-dependent arginine decarboxylase subunit beta</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="6">Pyruvoyl-dependent arginine decarboxylase subunit alpha</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="6" type="primary">pdaD</name>
        <name evidence="7" type="ORF">NTE_02137</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>L-arginine + H(+) = agmatine + CO2</text>
            <dbReference type="Rhea" id="RHEA:17641"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:58145"/>
            <dbReference type="EC" id="4.1.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="6">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the PdaD family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.19" evidence="6"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226986939.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRM2"/>
    <dbReference type="STRING" id="1459636.NTE_02137"/>
    <dbReference type="GeneID" id="41597865"/>
    <dbReference type="KEGG" id="nev:NTE_02137"/>
    <dbReference type="eggNOG" id="arCOG04490">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114389_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008792">
        <property type="term" value="F:arginine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006527">
        <property type="term" value="P:L-arginine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.20.10">
        <property type="entry name" value="Pyruvoyl-Dependent Histidine Decarboxylase, subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01404">
        <property type="entry name" value="PvlArgDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016104">
        <property type="entry name" value="Pyr-dep_his/arg-deCO2ase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016105">
        <property type="entry name" value="Pyr-dep_his/arg-deCO2ase_sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002724">
        <property type="entry name" value="Pyruvoyl-dep_arg_deCO2ase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00286">
        <property type="entry name" value="pyruvoyl-dependent arginine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40438">
        <property type="entry name" value="PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40438:SF1">
        <property type="entry name" value="PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01862">
        <property type="entry name" value="PvlArgDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005216">
        <property type="entry name" value="Pyruvoyl-dep_arg_deCO2ase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01170">
        <property type="entry name" value="Pyruvoyl-dependent_arginine_de"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00055">
        <property type="entry name" value="Pyruvoyl-Dependent_Histidine/A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56271">
        <property type="entry name" value="Pyruvoyl-dependent histidine and arginine decarboxylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="3 6 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 6" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_5023254953" description="Pyruvoyl-dependent arginine decarboxylase subunit beta" evidence="6">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023254954" description="Pyruvoyl-dependent arginine decarboxylase subunit alpha" evidence="6">
        <location>
            <begin position="55"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage (non-hydrolytic)" evidence="6">
        <location>
            <begin position="54"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser)" evidence="6">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF84191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="194" mass="21234" checksum="FEE9AD1F628EF21D" modified="2014-10-29" version="1">MESSSNMPVASPLLYVPKMMFFTKGKGIHKDNLTSFELALRDAEIADLNLVAVSSIKPPHCKITSTKEGRTHLRPGQIVFTIMARSATNEPNRLIAASIGLAMPADDSQYGYLSEHHSTGETAQKAGDYAEDMAMEMLATTLGLPNDPSLTWDQKEEQWKLSGKIYKTQNFTQSAEGNKDGLWTTVVSAAVLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MRY4</accession>
    <name>A0A075MRY4_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DNA polymerase II small subunit</fullName>
            <shortName evidence="15">Pol II</shortName>
            <ecNumber evidence="15">2.7.7.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Exodeoxyribonuclease small subunit</fullName>
            <ecNumber evidence="15">3.1.11.1</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">polB</name>
        <name evidence="18" type="ORF">NTE_00085</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 15">Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 15">Heterodimer of a large subunit and a small subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the DNA polymerase delta/II small subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="15"/>
    <dbReference type="EC" id="3.1.11.1" evidence="15"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987085.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MRY4"/>
    <dbReference type="STRING" id="1459636.NTE_00085"/>
    <dbReference type="GeneID" id="41596033"/>
    <dbReference type="KEGG" id="nev:NTE_00085"/>
    <dbReference type="eggNOG" id="arCOG04455">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027850_1_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008310">
        <property type="term" value="F:single-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00325">
        <property type="entry name" value="DNApol_II_A_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024826">
        <property type="entry name" value="DNA_pol_delta/II_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011149">
        <property type="entry name" value="Pol2_small_arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003118">
        <property type="entry name" value="PRK04036.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10416">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10416:SF0">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000803">
        <property type="entry name" value="Arc_Pol2_small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15" id="KW-0235">DNA replication</keyword>
    <keyword evidence="11 15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 15" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="9 15" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="8 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7 15" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5 15 18" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15 18" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="17">
        <location>
            <begin position="306"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="AIF82169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="498" mass="54420" checksum="1C4AF2F7B80334AE" modified="2014-10-29" version="1">MVLQSEIVNALSYATSKGYQIHPDAFAMLKGLETDVLKAVQEIIKQKKQTKMIVVDDVKNVVNPGRQEALAPVEQIAKVLVDPTPNVNTGEGVDGYALLFKSRFEKTMRILAQRPDSKRMTKISTVKQMGKGSTGPRPAGAAGERSLANAGTYVVSGLLMSRRTKKNGIELEVDDYTGRLQVTAASEDAKKQAANLALDQVVMLELENAKGVQGLAIKNVFSPDIPDHLPNKSRSEAYAVLISDLHVGSKYFMQQEFLRFLDWLASGDDDDVVRKIKFLCIGGDLIDGIGIFPNQDKELLMMNAAAQMAHTAKLLSKIPKHIKTFIIPGNHDPGRRALPQPIFPEATSGGLYNLENCTMLGNPAYIELNGVKVLMFHGQSLDDVIATTPGMSYQRPAEAMKVLLKARHLSPTYGGRTPVAPESEDMMVMTEVPDIFHAGHVHVTDVDSYRGTLVVNSGAWQAQTKFQQTMGITPSPGIAIVVNLATLQPFKQDFNLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MS36</accession>
    <name>A0A075MS36_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Diadenosine 5',5'''-P1,P4-tetraphosphate asymmetrical hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NTE_02277</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385419.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MS36"/>
    <dbReference type="STRING" id="1459636.NTE_02277"/>
    <dbReference type="GeneID" id="41597992"/>
    <dbReference type="KEGG" id="nev:NTE_02277"/>
    <dbReference type="eggNOG" id="arCOG01078">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037162_14_4_2"/>
    <dbReference type="OrthoDB" id="25379at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004081">
        <property type="term" value="F:bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006167">
        <property type="term" value="P:AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006754">
        <property type="term" value="P:ATP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03428">
        <property type="entry name" value="NUDIX_Ap4A_Nudt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051325">
        <property type="entry name" value="Nudix_hydrolase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003565">
        <property type="entry name" value="Tetra_PHTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21340:SF0">
        <property type="entry name" value="BIS(5'-NUCLEOSYL)-TETRAPHOSPHATASE [ASYMMETRICAL]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21340">
        <property type="entry name" value="DIADENOSINE 5,5-P1,P4-TETRAPHOSPHATE PYROPHOSPHOHYDROLASE MUTT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="6">
        <location>
            <begin position="9"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF84331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="145" mass="16718" checksum="070E742E709FD9C0" modified="2014-10-29" version="1">MNTVVRKVALEQSVGAVIKFLPDDTVAEFLLLRNRRGFWGFPQGHKEKGETDIQTLVREVKEETGISQLEIHNYIGKITYSYFKGDGMRSEKQVSFYFATTPTREIKISEEHADSRWATLKDAFSLLDHAKLRQILDRGHQKGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSA8</accession>
    <name>A0A075MSA8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148699269.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSA8"/>
    <dbReference type="STRING" id="1459636.NTE_00152"/>
    <dbReference type="GeneID" id="41596090"/>
    <dbReference type="KEGG" id="nev:NTE_00152"/>
    <dbReference type="HOGENOM" id="CLU_149772_0_0_2"/>
    <dbReference type="OrthoDB" id="12152at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="141" mass="15828" checksum="89CE93A0A9372231" modified="2014-10-29" version="1">MPAVDEVRVAFENLQQKYKEHLPKVDTVLIENLLKRKMEDPSNDPIFMVEVFTKPGLDPQQVRSYIIQKTGMSPEIYDNGTHYVTNQKLNLKILKEISDSDDVLEVTGEYTGRIGAYGASHEHRETEDTPGAATGRGKPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSG9</accession>
    <name>A0A075MSG9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Exosortase/archaeosortase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NTE_01676</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987234.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSG9"/>
    <dbReference type="STRING" id="1459636.NTE_01676"/>
    <dbReference type="GeneID" id="41597449"/>
    <dbReference type="KEGG" id="nev:NTE_01676"/>
    <dbReference type="eggNOG" id="arCOG08669">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076510_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026392">
        <property type="entry name" value="Exo/Archaeosortase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027561">
        <property type="entry name" value="Thauma_sortase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04178">
        <property type="entry name" value="exo_archaeo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04297">
        <property type="entry name" value="thauma_sortase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="265"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF83737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="346" mass="37753" checksum="D14F70093F51D34E" modified="2014-10-29" version="1">MSGDRAAPSPSQQAAAPTIFGINSSVAVTLVLISPIIFTLVVYPDSFNLSWNEGRGGFIFAMAFIAAELVGVRQPVSKRKFLVVAGLAALTIGYFAALPYGLHDSIRDTGLSYGIRSEVIGSWMFMWDFVVMALFVGASLVVLFGKKWYKIAPAGAIYLAGSAVILSLDAFFPYDTLGPLQIIVPAYLQIDQAVIRFIDTNIMDIGKGVVATARGNLLVLNGLHGPFALQVFWPSAGVHSMIIYTLVMLAFLLKMEIPLKRKLIYFAIGTLGTVAVNVVRIISLTMYALIVTANPREWEAFHSVAGEIMFLPWLGIYLGIVMYTEGRRLRRMRQQQASTTPSSTSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSM5</accession>
    <name>A0A075MSM5_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00267</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSM5"/>
    <dbReference type="STRING" id="1459636.NTE_00267"/>
    <dbReference type="KEGG" id="nev:NTE_00267"/>
    <dbReference type="HOGENOM" id="CLU_3056944_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="53" mass="6061" checksum="AD7A5FABB6537E40" modified="2014-10-29" version="1">MPGIRCQFCGIPLDNEKQFIGHYIIGHELTLESARSIWNSESGLIVMNEKERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSR0</accession>
    <name>A0A075MSR0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Seryl-tRNA synthetase</fullName>
            <shortName evidence="7">SerRS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Seryl-tRNA(Ser/Sec) synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">serS</name>
        <name evidence="12" type="ORF">NTE_01756</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>tRNA(Sec) + L-serine + ATP = L-seryl-tRNA(Sec) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42580"/>
            <dbReference type="Rhea" id="RHEA-COMP:9742"/>
            <dbReference type="Rhea" id="RHEA-COMP:10128"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>tRNA(Ser) + L-serine + ATP = L-seryl-tRNA(Ser) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12292"/>
            <dbReference type="Rhea" id="RHEA-COMP:9669"/>
            <dbReference type="Rhea" id="RHEA-COMP:9703"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; L-seryl-tRNA(Sec) from L-serine and tRNA(Sec): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer. The tRNA molecule binds across the dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="7"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700519.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSR0"/>
    <dbReference type="STRING" id="1459636.NTE_01756"/>
    <dbReference type="GeneID" id="41597526"/>
    <dbReference type="KEGG" id="nev:NTE_01756"/>
    <dbReference type="eggNOG" id="arCOG00403">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023797_0_1_2"/>
    <dbReference type="OrthoDB" id="35932at2157"/>
    <dbReference type="UniPathway" id="UPA00906">
        <property type="reaction ID" value="UER00895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016260">
        <property type="term" value="P:selenocysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00770">
        <property type="entry name" value="SerRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000048">
        <property type="entry name" value="Serine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="entry name" value="Serine-tRNA synthetase, tRNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00176">
        <property type="entry name" value="Ser_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033729">
        <property type="entry name" value="SerRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="SERYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="tRNA-binding arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="11">
        <location>
            <begin position="138"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="30"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="229"/>
            <end position="231"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <begin position="260"/>
            <end position="262"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="276"/>
            <end position="279"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <begin position="347"/>
            <end position="350"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="381"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="383"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for serine binding" evidence="8">
        <location>
            <position position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIF83817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="425" mass="48552" checksum="8F111CA9EDC4BB17" modified="2014-10-29" version="1">MLDPKLLKDNPDAVHEMLNKRNVEFPLDELVALERRRRELITESQEYRSRKNKLSEAVAAKKKAKQDASAELEQMKEVGTNMERVEQEKVAAEDKYRKLAALLPNMLHESVPVGKDEKDNVVVKTASGKIRSIDKPKDHVDIATALDLFDIERAAKVSGARFYFLKNELVRMNTALVHFALDYLTEKGYTLVQPPYMIHREPMEGAVILGDFEDVIYKIENEDLYMIGTSEHAIAGMHMDEILEGKQLPVRYAGVSPCFRKEAGAHGKDMKGIFRVHQFEKVEQFVYCRPEDSWKEHEHMLEVSQGFFDALGIPYRVMLLCSGDTGKISAKTYDIEAWMPGQGAYREIVSCSNCTDYQARRLAIRFRDKTNEETRFVHTLNSTLVAVQRTLVAIMENYQTPSGTVQVPEVLQKYMGDLKEIKPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSU9</accession>
    <name>A0A075MSU9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_00347</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSU9"/>
    <dbReference type="KEGG" id="nev:NTE_00347"/>
    <dbReference type="HOGENOM" id="CLU_2874899_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF82429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="63" mass="7474" checksum="D959699F95BEF0EB" modified="2014-10-29" version="1">MSLQYYSCINFNSLFQKEDSRPNFGYILPAFLAVVLRIDMMFKDAGSFLILTKYYPYSTMDFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MSW7</accession>
    <name>A0A075MSW7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Enoyl-CoA hydratase/carnithine racemase</fullName>
            <ecNumber evidence="4">4.2.1.55</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_02211</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.55" evidence="4"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MSW7"/>
    <dbReference type="STRING" id="1459636.NTE_02211"/>
    <dbReference type="KEGG" id="nev:NTE_02211"/>
    <dbReference type="eggNOG" id="arCOG00249">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_7_6_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000009">
        <property type="entry name" value="Carnitinyl-CoA dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF54">
        <property type="entry name" value="ENOYL-COA HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF84265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="286" mass="30546" checksum="B03F71C006C64DA2" modified="2014-10-29" version="1">MSTMKYIQLEPHGDIAVVRINRPEALNAMNVDVISELSRTIDILAADDGIKCVIITGAGERAFCAGADIAFMVNIEPMAAEKYASAAQAVLNKIEKLEKPVIAAVNGFALGGGCELAMVCDIRIASENAKIGQPEVTIGIPPGWGGTQRLLRIVGPAKAKEMIYTGKMITADEAASIGLVNKVVKLGADDQLPPEAPKGDAAAEKARAAEVAKILNKKLMADCMALAKEITKNSFTAVKVSKMLINRGMDSDIETGLRLEIYGWALCFAHEDRKNMMSAFLNKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTB1</accession>
    <name>A0A075MTB1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01979</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700690.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTB1"/>
    <dbReference type="STRING" id="1459636.NTE_01979"/>
    <dbReference type="GeneID" id="41597727"/>
    <dbReference type="KEGG" id="nev:NTE_01979"/>
    <dbReference type="HOGENOM" id="CLU_193460_0_0_2"/>
    <dbReference type="OrthoDB" id="11987at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="73" mass="8362" checksum="EF79C3386DD58036" modified="2014-10-29" version="1">MVAASPETKLEGLEAKEEKENENDESKEESVALLMEQDIECPRCHGSMVLCSDFDSLYYSCEECDFTLYTIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTC2</accession>
    <name>A0A075MTC2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Arabinose efflux permease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NTE_02785</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701335.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTC2"/>
    <dbReference type="STRING" id="1459636.NTE_02785"/>
    <dbReference type="GeneID" id="41598474"/>
    <dbReference type="KEGG" id="nev:NTE_02785"/>
    <dbReference type="eggNOG" id="arCOG00132">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025894_2_0_2"/>
    <dbReference type="OrthoDB" id="56622at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23520">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G04000)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23520:SF5">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G04000)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="371"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF84826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="413" mass="44550" checksum="98B559A655845E9E" modified="2014-10-29" version="1">MGWLSADGKLVFSARIVRTFAYGFLSIVLAIYLKLLGFDDILIGIVLTATLVNSVIFTLFASFYADRIGRRKTLILFGALMSIAGAIFLASESYLALIAAALIGTINVTGSETGAFLSLEQALLPQTVNDSRKRNTVFALYNMAGTFAMSGGILLSGLPAILQQQYGWNPVESIKPLFLLYSVLGIVATAIYFMLSNKIEATTRDITNKKKPVTQALSPQSKHLVGKLSGLFAVDSFAGGFVIQSIVSFWFFTKFNVDLAVLSLIFSVAGVLTAFSFLAAAKIADRIGLVNTMVFTHIPSNVFLILVGFAPSLPLAIAFYLTRMALSQMDVPTRQSYIVAVVSEEERTPAAGITNMSRNISQAVSPSLTGYILQVLPVLSAPFVLGGALKIAYDIALYLNFRNVRPVEGKNSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTN8</accession>
    <name>A0A075MTN8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_00568</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF82649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Integrin alpha, N-terminal"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF82649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="324" mass="34878" checksum="85B9849FE28B7777" modified="2014-10-29" version="1">MNNTIINNKKRYKTPAIVISMMLVSGMFSIAATQEPNLAAAQTPSPDLFAFKKSGTKSNSTEVYAIPGTNPQQLLLQTGTALPETDETYEFAVDDWNHDGTADIVAIKMSDTKSNSTEVEVLDGASNFTTFLLDTGTALPDTDETYDFGFDDWNNDGSSDLVAIKMTNTATNSTEVQVLDGASNFTAFLVQTSTALPETGDGFDFAVDDWNNDGTADVIAIKMANTQSNSTEIQVVSGADPQKFLVQTSTALPQAGEEFDFAADDWNNDGTSDLVAIKMIDTETNGTELHVISGANPQQFLVQTGTALPETGETYDFDTWKARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTQ2</accession>
    <name>A0A075MTQ2_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02966</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701475.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTQ2"/>
    <dbReference type="STRING" id="1459636.NTE_02966"/>
    <dbReference type="GeneID" id="41598637"/>
    <dbReference type="KEGG" id="nev:NTE_02966"/>
    <dbReference type="HOGENOM" id="CLU_2534789_0_0_2"/>
    <dbReference type="OrthoDB" id="10720at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="84" mass="9132" checksum="55A695187F48403C" modified="2014-10-29" version="1">MSSQNNNNNYIAELVDSLHGLIESRQAPADVAIAGLISTAGEIALGMAVARPEHKEAYLKAFNSAVEQVRRQLRKELKSRGLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTX1</accession>
    <name>A0A075MTX1_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4386 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02592</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701171.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTX1"/>
    <dbReference type="GeneID" id="41598286"/>
    <dbReference type="KEGG" id="nev:NTE_02592"/>
    <dbReference type="eggNOG" id="ENOG502N5B3">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1131774_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="251" mass="27394" checksum="0126139BDDD5023A" modified="2014-10-29" version="1">MQSSKMRNWSPLLRIGAILAFAGVVTYGVSWPIHPGVPDASDWARSAQAYAESDNWVTIHLAQLSGLLFLFLGLAILAEALRREYRGTIVEALAFLALVTTILTASVFATLQAVDGISLKAMVDRWANAPANEKAVAFRVSESVRYIEIGLNSPFRFLQAISAFLIGAAIALTFNKENPYPKARILGGVAIAIGIGMALRGYAISYTGFSEQNPLYSQTHLFILILLLWMVAIGIAMWKRRSPALLAPVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MTX6</accession>
    <name>A0A075MTX6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2H2-type zinc finger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_03072</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_193354077.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MTX6"/>
    <dbReference type="GeneID" id="59387795"/>
    <dbReference type="KEGG" id="nev:NTE_03072"/>
    <dbReference type="eggNOG" id="arCOG10404">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_214142_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF85106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="52" mass="5812" checksum="BCE0F317994B4541" modified="2014-10-29" version="1">MEDIISGGNNNRSNGVSCPYCQSKFATSEEMSKHVDRMHHGSGLLEGDSRRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MU00</accession>
    <name>A0A075MU00_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA-directed RNA polymerase subunit Rpo10</fullName>
            <ecNumber evidence="5">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">DNA-directed RNA polymerase subunit N</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpo10</name>
        <name evidence="5" type="synonym">rpoN</name>
        <name evidence="6" type="ORF">NTE_02590</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the RNA polymerase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="5"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_075054423.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MU00"/>
    <dbReference type="STRING" id="1459636.NTE_02590"/>
    <dbReference type="GeneID" id="41598284"/>
    <dbReference type="KEGG" id="nev:NTE_02590"/>
    <dbReference type="eggNOG" id="arCOG04244">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_143122_2_1_2"/>
    <dbReference type="OrthoDB" id="371754at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00250">
        <property type="entry name" value="RNApol_arch_Rpo10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023580">
        <property type="entry name" value="RNA_pol_su_RPB10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020789">
        <property type="entry name" value="RNA_pol_suN_Zn-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000268">
        <property type="entry name" value="RPABC5/Rpb10"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003089">
        <property type="entry name" value="PRK04016.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23431:SF3">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23431">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01194">
        <property type="entry name" value="RNA_pol_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005653">
        <property type="entry name" value="RNA_pol_N/8_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46924">
        <property type="entry name" value="RNA polymerase subunit RPB10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01112">
        <property type="entry name" value="RNA_POL_N_8KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 5 6" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AIF84633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="78" mass="9050" checksum="B9551758DBB1FF06" modified="2014-10-29" version="1">MLVPVRCFTCGGLIADKYGEYSNRVKAGEDPAKVMDSLGVKRYCCRRMFISTVETIYQIIPYYEALRRRMSEVQTEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MU33</accession>
    <name>A0A075MU33_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SnoaL-like domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701195.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MU33"/>
    <dbReference type="GeneID" id="41598314"/>
    <dbReference type="KEGG" id="nev:NTE_02620"/>
    <dbReference type="HOGENOM" id="CLU_153137_0_0_2"/>
    <dbReference type="OrthoDB" id="374898at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="18"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="124" mass="14277" checksum="D0DA0513F83AE9DA" modified="2014-10-29" version="1">MQKQHESSAKNAKEIVMEYLQALTERRDFESARSYLKDNVSYVSPLNSFDNAEAYLKYNESLHLPKPDIKKIFTDGDDVCLLYEMTLTTQPAPLFVSFWAHVDSGKISSINVNFDPRPFIRPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MU42</accession>
    <name>A0A075MU42_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein GrpE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NTE_03149</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GrpE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701624.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MU42"/>
    <dbReference type="STRING" id="1459636.NTE_03149"/>
    <dbReference type="GeneID" id="41598808"/>
    <dbReference type="KEGG" id="nev:NTE_03149"/>
    <dbReference type="eggNOG" id="arCOG04772">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057217_6_0_2"/>
    <dbReference type="OrthoDB" id="372230at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00446">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.22.10:FF:000001">
        <property type="entry name" value="Protein GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="entry name" value="Head domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01151">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013805">
        <property type="entry name" value="GrpE_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237">
        <property type="entry name" value="GRPE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237:SF23">
        <property type="entry name" value="GRPE PROTEIN HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00773">
        <property type="entry name" value="GRPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58014">
        <property type="entry name" value="Coiled-coil domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="Head domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01071">
        <property type="entry name" value="GRPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 10" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIF85181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="203" mass="22667" checksum="E06A6C9B0E666410" modified="2014-10-29" version="1">MVAEEEAAAEEKVNAGKEREEAEEEEMQQQIDEIEKLRKELAAAKEAAEGYLNKLKYLMADFDNYRKQMEKHAASRVETIKAELLLKFLNIRDDYQRAVESARQKKSEPAVIEGLEGILKNIDSLLSSEGVMPIEAVGTPFDPSVHDAIAFSPREDAKENTVTAEIRRGYMLNGKVLRPSMVEIARKIVKNSDVANNGGAGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUA8</accession>
    <name>A0A075MUA8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02723</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701281.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUA8"/>
    <dbReference type="STRING" id="1459636.NTE_02723"/>
    <dbReference type="GeneID" id="41598413"/>
    <dbReference type="KEGG" id="nev:NTE_02723"/>
    <dbReference type="HOGENOM" id="CLU_2165143_0_0_2"/>
    <dbReference type="OrthoDB" id="9081at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="110" mass="12606" checksum="719EAD9F674A7DDF" modified="2014-10-29" version="1">MSHRPKPVRDHYTESLAVNSENLGKQLSAESVPREQVQKILDSISRLYLAETEKIVHECEKDMMALERVPSPLRLFIDSIAQVMTMKSNAISPAAFTLLKRYASAWEDWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUI8</accession>
    <name>A0A075MUI8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02842</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701378.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUI8"/>
    <dbReference type="STRING" id="1459636.NTE_02842"/>
    <dbReference type="GeneID" id="41598524"/>
    <dbReference type="KEGG" id="nev:NTE_02842"/>
    <dbReference type="HOGENOM" id="CLU_851570_0_0_2"/>
    <dbReference type="OrthoDB" id="11292at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="310" mass="32920" checksum="E3EE79379950EB33" modified="2014-10-29" version="1">MERKSTTALLLAAMMVGGLAYASAGQQRAFAHNFSGDESAAFLANVDTLKIHLMLVGGNYVGNHDSARQHAEHAAEHLSAATIKEIAERNQRLGTDLPAALGKLKTSVEGNSPRSEIVQQIKDINGLLGETVAARIDKSQLTNSTVNALVFADLVNEILESYQGAYGVMEEGDHDHSSGSMNMTGSSSSAMEEGAHDKVVNMPAYQSARWLALKASSMYYKLSAVAPAGSEASMAKLRSGLDELKNAVDGQSSLEAVTVIVHGKVHQNLMDAFSLPMEEEGSSSDHDQETEISGNMTGNMTGSMEGNMTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUM0</accession>
    <name>A0A075MUM0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_158385651.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUM0"/>
    <dbReference type="STRING" id="1459636.NTE_03332"/>
    <dbReference type="GeneID" id="43502677"/>
    <dbReference type="KEGG" id="nev:NTE_03332"/>
    <dbReference type="HOGENOM" id="CLU_3113201_0_0_2"/>
    <dbReference type="OrthoDB" id="374884at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="19"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="51" mass="5842" checksum="A4B5701957D8FBE0" modified="2014-10-29" version="1">MQDYQSNIPKDRDKSGIPVVCSKCNATFASDSAYMSHYNQEHEKDEEQQTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUN0</accession>
    <name>A0A075MUN0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02787</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701337.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUN0"/>
    <dbReference type="STRING" id="1459636.NTE_02787"/>
    <dbReference type="GeneID" id="41598476"/>
    <dbReference type="KEGG" id="nev:NTE_02787"/>
    <dbReference type="HOGENOM" id="CLU_1067996_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="243" mass="25470" checksum="F3C8DA4B2C437F75" modified="2014-10-29" version="1">MIAKTAAASIMMGIVFATALSFAGILIPTQIQAQNMTEPTNNMTAMNNSNSNSSVLAGGAVNSTGLDTFSAAGPIAGLILPASPAESNSTGSNMTLPSSSSQNTTALASVVPAKTFILSGAWHLNAENGKVTFFDARFTKVHLDASNRHVHEISNFRPASNDTSIRLNANGTTTIMGTTDVALNHAITWTNVKTAIVIDKLSTITIMLDPKDTSNHFVGQSIYGTVSMLKDKNGNHVAMFARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUQ1</accession>
    <name>A0A075MUQ1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUQ1"/>
    <dbReference type="KEGG" id="nev:NTE_03368"/>
    <dbReference type="HOGENOM" id="CLU_1202583_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="230" mass="25376" checksum="70788C04BD6A5979" modified="2014-10-29" version="1">MELLGLVSLGTASAYFGLSDWKTRVVDHRAILACYVLAVCVNSAIILTAAFTTIDKSTSSHESTISEWLAIIKESAIATILRAHGSIFAVLFLACTLFVFYRLNLLALGDALAIPAMLVMLLLAARPIEIIVYFVSALVFVLAISVGRNLGNNVRCREALNGPLRRRLYLLLFCYYGDGAACRYSFRYTGGTRRNYDRESYYVGTEKTWLVPGIPMLSGFMPAILVLLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUT8</accession>
    <name>A0A075MUT8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Urease subunit alpha</fullName>
            <ecNumber evidence="5">3.5.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">NTE_02890</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SR1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Ni cation</name>
            <dbReference type="ChEBI" id="CHEBI:25516"/>
        </cofactor>
        <text evidence="7">Binds 2 nickel ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (urease route): step 1/1.</text>
    </comment>
    <comment type="PTM">
        <text evidence="6">Carbamylation allows a single lysine to coordinate two nickel ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.5" evidence="5"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701416.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MUT8"/>
    <dbReference type="STRING" id="1459636.NTE_02890"/>
    <dbReference type="GeneID" id="41598569"/>
    <dbReference type="KEGG" id="nev:NTE_02890"/>
    <dbReference type="eggNOG" id="arCOG00698">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000980_0_0_2"/>
    <dbReference type="OrthoDB" id="42542at2157"/>
    <dbReference type="UniPathway" id="UPA00258">
        <property type="reaction ID" value="UER00370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009039">
        <property type="term" value="F:urease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00375">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01953">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011612">
        <property type="entry name" value="Urease_alpha_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050112">
        <property type="entry name" value="Urease_alpha_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005848">
        <property type="entry name" value="Urease_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017951">
        <property type="entry name" value="Urease_asu_c"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009686">
        <property type="entry name" value="PRK13207.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01792">
        <property type="entry name" value="urease_alph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43440">
        <property type="entry name" value="UREASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43440:SF1">
        <property type="entry name" value="UREASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00449">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01752">
        <property type="entry name" value="UREASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="135"/>
            <end position="575"/>
        </location>
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        <location>
            <position position="328"/>
        </location>
    </feature>
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        <location>
            <position position="140"/>
        </location>
        <ligand>
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        <ligand>
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        <ligand>
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            <label>1</label>
        </ligand>
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        <location>
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        </location>
        <ligand>
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        <location>
            <position position="254"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
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        <location>
            <position position="280"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:49786"/>
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            <position position="368"/>
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        <ligand>
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            <label>1</label>
        </ligand>
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        <location>
            <position position="225"/>
        </location>
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        <source>
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        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="575" mass="61917" checksum="7E280F5DAECBAAD5" modified="2014-10-29" version="1">MVLKLTRKQYTDLFGPTTGDKVRIGDTDLVIQIEKDLITPGDECVFGGGKTLRDGLAQTSGVTNKNGALDFVITNAVILDPVLGIVKADIGIKDGKIAGVGKAGNPLTMDGVNPNMVVSACTEATAGEHTICTAGHFDTHIHMISPQQYIDGISGGICNMIGGGTGPADGTNATTCTPGVYNISRMMEAVEDTPMNWGFLGKGNDSHPTLATQLEQIDAGACGLKDHEDWGTTAAVLDASLRAADLTDTQVAIHTDSINECAYVEDTINAIDGRVVHTYHTEGAGGGHAPDIMKIAGEMFALPSSTNPTRPYTKNTVDEHLDMLMFCHHLNPAVAEDVAFADSRIRAETIAAEDVLHDEGVLSMYSSDSQAMGRIGEVVIRAWQTADKMKKMKGRLPQETGDNDNFRAKRYIAKTTINPAITHGVSDYLGSLEVGKYADIVMYPMAFFPAKPKMVLKGGFIAWSIMGDPNASLPTPEPVYYRPMFGAFGKAVHKTSYTFTSKRAMELGVPQKLGLEKVCLPVKNCRNISKKNMMWNDETPKITIDPETYEVKLDGKIATVGPADELSLAQRYFMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MUV2</accession>
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        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
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    </reference>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="91" mass="10109" checksum="DA1F248B3E5EC918" modified="2014-10-29" version="1">MKGGSTSRVVRATAGADKTLMKTTFLSYYISMYNTVNEKVGYPNAPVTVDEIYDFLQDLKHEAGEPIPDIAKEDISFSFYVLKMLGICKCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MV02</accession>
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        <submittedName>
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        <name evidence="3" type="ORF">NTE_03458</name>
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        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
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                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
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                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
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    </reference>
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        <text evidence="1">Belongs to the SsuE family. Isf subfamily.</text>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="3"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF85486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="81" mass="9376" checksum="FAF1AFF550D4F8FA" modified="2014-10-29" version="1">MLKVAIILGSTRPGRNGEAVAKWVYDIAKKRTDAEFEYVDIKDYKISRCWMNRFCLRKGNTPKTIPKLGRPRLIPLTHLCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MV35</accession>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">NTE_03488</name>
    </gene>
    <organism evidence="1 2">
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MV35"/>
    <dbReference type="KEGG" id="nev:NTE_03488"/>
    <dbReference type="HOGENOM" id="CLU_3371269_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="34" mass="3704" checksum="8884EEC60FB18B7F" modified="2014-10-29" version="1">MLNPMADPIFISVVMLVDPTKCCDSSKSIAHLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MV81</accession>
    <name>A0A075MV81_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Family 3 adenylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02513</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MV81"/>
    <dbReference type="STRING" id="1459636.NTE_02513"/>
    <dbReference type="KEGG" id="nev:NTE_02513"/>
    <dbReference type="eggNOG" id="arCOG07810">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057456_1_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009190">
        <property type="term" value="P:cyclic nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050697">
        <property type="entry name" value="Adenylyl/Guanylyl_Cyclase_3/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43081:SF1">
        <property type="entry name" value="ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43081">
        <property type="entry name" value="ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="1">
        <location>
            <begin position="73"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="260" mass="28504" checksum="F9823BAA39FBFF8B" modified="2014-10-29" version="1">MFYVKGIHFRFGQIFLPAKGNVGSGALLSPTIDLKQIQARAERTIEKGVQIDLSTALCKRYLRRHANQKTSVVVLYVDIDGSTKLTQSVPSTQLALILQLFSQEMSLLVSNYGGYVLKYVGDAVIALFPAEHDVERACKNALECGWTMLEAIGGGINPALKSHGLPELGIKVSMDYGEVLVVLYGKSLENSHIDIIGSNISMAAKMLAFAPSGSIIMGMRARDNLGKAGGKDIQEIHDPDWSYTDEKTGGRYRLYRSSRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVA6</accession>
    <name>A0A075MVA6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701135.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVA6"/>
    <dbReference type="STRING" id="1459636.NTE_02545"/>
    <dbReference type="GeneID" id="41598241"/>
    <dbReference type="KEGG" id="nev:NTE_02545"/>
    <dbReference type="HOGENOM" id="CLU_1880966_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="135" mass="15511" checksum="4338F87A5FC1F3A7" modified="2014-10-29" version="1">MGDINSFNVDDIPLSKKSSNVVAGDINVGKKSPAELEQVHIEEDLQTQLAVTDSIFSLQSLDDKTQRELAEFAGYYYERGRITQPTIQALIQYHFDKIMDSIRSEYESHIFNKQLEEAMMRSMGIKPEDIDKFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVK1</accession>
    <name>A0A075MVK1_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative PLP-dependent enzyme possibly involved in cell wall biogenesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_03161</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DegT/DnrJ/EryC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987043.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVK1"/>
    <dbReference type="STRING" id="1459636.NTE_03161"/>
    <dbReference type="GeneID" id="41598819"/>
    <dbReference type="KEGG" id="nev:NTE_03161"/>
    <dbReference type="eggNOG" id="arCOG00118">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033332_7_2_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00616">
        <property type="entry name" value="AHBA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244:SF34">
        <property type="entry name" value="DTDP-4-AMINO-4,6-DIDEOXYGALACTOSE TRANSAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="TRANSAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000390">
        <property type="entry name" value="PLP_StrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF85193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="372" mass="40228" checksum="C85A820FE2AEB042" modified="2014-10-29" version="1">MIPINKPQLGEEEKREVMSVMEENALTSAASDGGKRVRDFESLMREYLGCKHVVAVNSGTAALHAALLAAEIGPGDEVLVPSFTFVATANAVVASGAKPVFVDVNKQDYTIDVSDAKRKTTKKTKAVIPVHLYGHPCDMDAVSELAQKRSLAVIEDACQSLGSTYKKRQTGTFGQMGCFSMYASKVLTSGEGGAITTDDSDLADKLKMIRNHGMVKGYDTRILGLNMRLPELAAAIAKVQMTKLAAMLAARRKNAELMSELLQGAAAKEVSLPQESDDRVFNWYLYTICFAKGAARDSVMARLQKEGIGATVYYDPPVHKTPYYRKFAARLPATEWCAGRVLSLPVHPGVQDGDVRRTAAEMALALSSPMAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVP0</accession>
    <name>A0A075MVP0_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-hydroxy-3-methylglutaryl coenzyme A reductase</fullName>
            <shortName evidence="3">HMG-CoA reductase</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">NTE_03194</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the HMG-CoA reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_226987045.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVP0"/>
    <dbReference type="STRING" id="1459636.NTE_03194"/>
    <dbReference type="GeneID" id="41598851"/>
    <dbReference type="KEGG" id="nev:NTE_03194"/>
    <dbReference type="eggNOG" id="arCOG04260">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033422_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004420">
        <property type="term" value="F:hydroxymethylglutaryl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015936">
        <property type="term" value="P:coenzyme A metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00644">
        <property type="entry name" value="HMG-CoA_reductase_classII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.770.10">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl-coenzyme A Reductase, Chain A, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002202">
        <property type="entry name" value="HMG_CoA_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004553">
        <property type="entry name" value="HMG_CoA_Rdtase_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023074">
        <property type="entry name" value="HMG_CoA_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023076">
        <property type="entry name" value="HMG_CoA_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009023">
        <property type="entry name" value="HMG_CoA_Rdtase_NAD(P)-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009029">
        <property type="entry name" value="HMG_CoA_Rdtase_sub-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00532">
        <property type="entry name" value="HMG_CoA_R_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572:SF24">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00368">
        <property type="entry name" value="HMG-CoA_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00071">
        <property type="entry name" value="HMGCOARDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55035">
        <property type="entry name" value="NAD-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56542">
        <property type="entry name" value="Substrate-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01192">
        <property type="entry name" value="HMG_COA_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50065">
        <property type="entry name" value="HMG_COA_REDUCTASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AIF85223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="419" mass="44526" checksum="EF5CD7BDEC7FCBD4" modified="2014-10-29" version="1">MSQEKRKFYEMDREERLAFLKESAGLTDEEAASFGQPLAFDSANRMVENAVGIMSIPLGIATNFVINGVERLVPMAIEEPSVIAAASKAAKIAKAKGGFVAETDEPLMIGQVQVVSLANIGAAKRKVLARKKEILAIANSKSRSVSAAGLQAREVKDSSKNKMGRMLVVELVIDAKDAMGANAVNTMCEAIAPRVAEITGGEVVLKILSNYATKRMVRCKAVFDRDELGGKDIVERILYAYALAHSDVYRAVTHNKGVMNGVDAVALATGQDFRAIEAGAHAWAARDGTYRSLTRWWRTKNGDLAGEIELPLAVGVVGGVANVHPTAKVALKVLSASNNAKELAMAIAAAGLAQNLAAMRALASEGIQKGHMRLHARNIAVMAGAKGADVDRVAKKIADEGQVNVEKAREVLASLRKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVQ0</accession>
    <name>A0A075MVQ0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RecA-superfamily ATPase possibly involved in signal transduction</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">NTE_03296</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVQ0"/>
    <dbReference type="STRING" id="1459636.NTE_03296"/>
    <dbReference type="KEGG" id="nev:NTE_03296"/>
    <dbReference type="eggNOG" id="arCOG01171">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_551677_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009190">
        <property type="term" value="P:cyclic nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014774">
        <property type="entry name" value="KaiC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010624">
        <property type="entry name" value="KaiC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43637">
        <property type="entry name" value="UPF0273 PROTEIN TM_0370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06745">
        <property type="entry name" value="ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51146">
        <property type="entry name" value="KAIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KaiC" evidence="4">
        <location>
            <begin position="7"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="3">
        <location>
            <begin position="296"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF85325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="485" mass="52281" checksum="452AD492CA1140B4" modified="2014-10-29" version="1">MHDDGDVAVVESIPGLRHVFFKGALPKGAFLLTGPAGSGKTMYCMQFLRDGIAAGERCLYVSFDPLFSKEKFRESLGSQKDDYEESFIAPTTASFFKSGKKDPGRAAALLEQVRRAVDSGAPARVAVDSVTHLLPHFSEGEVLEIVAELASVLRGASAMAIITLTTVPSKGDLSDTIASLLDGTLQIKLEDEGKDLARSLRLLAVRGTYHNPAWARFSITEKGTLMFGQEEQEDDGQAQAEPAITCKLCDKPIAGKVAYDADAPFHPHCLETYRKLSDIYGSSVVYAIPVGVINASFFFIDIVGLSDPSLSVEKQIKKIENLNRLISSCDAVARAPKDKRIILPTGDGMAIGFLMNPELPLQLSMQLHRKLGAFNKSAGAGEAIGVRIGLSAGPVFVVSDINGNQNVWGPGIILARRVMDIGDDRHILLADSLAEQLINLKDEYRRIIKLVSPKFTIKHGQAIKVYSASSADFGNPKVPARLAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MVY8</accession>
    <name>A0A075MVY8_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">A-type ATP synthase subunit A</fullName>
            <ecNumber evidence="10">7.1.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">atpA</name>
        <name evidence="12" type="ORF">NTE_03279</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the A-type ATP synthase that produces ATP from ADP in the presence of a proton gradient across the membrane. The A chain is the catalytic subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O + 4 H(+)(in) = ADP + phosphate + 5 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Has multiple subunits with at least A(3), B(3), C, D, E, F, H, I and proteolipid K(x).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="10"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701736.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MVY8"/>
    <dbReference type="STRING" id="1459636.NTE_03279"/>
    <dbReference type="GeneID" id="41598933"/>
    <dbReference type="KEGG" id="nev:NTE_03279"/>
    <dbReference type="eggNOG" id="arCOG00868">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008162_3_1_2"/>
    <dbReference type="OrthoDB" id="115235at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18111">
        <property type="entry name" value="ATP-synt_V_A-type_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18119">
        <property type="entry name" value="ATP-synt_V_A-type_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01134">
        <property type="entry name" value="V_A-ATPase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.20:FF:000002">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="entry name" value="Bovine Mitochondrial F1-atpase, Atp Synthase Beta Chain, Chain D, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00309">
        <property type="entry name" value="ATP_synth_A_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031686">
        <property type="entry name" value="ATP-synth_a_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022878">
        <property type="entry name" value="V-ATPase_asu"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003220">
        <property type="entry name" value="PRK04192.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607:SF1">
        <property type="entry name" value="H(+)-TRANSPORTING TWO-SECTOR ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607">
        <property type="entry name" value="V-TYPE PROTON ATPASE CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16886">
        <property type="entry name" value="ATP-synt_ab_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 10" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="227"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="235"/>
            <end position="242"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AIF85308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="600" mass="66209" checksum="111A295A7117A3B1" modified="2014-10-29" version="1">MVAKGRIVWVSGPAVKADGMSAAKMYETVEVGDSKLIGEVIRLTGDVAFIQVYESTSGLKPGEPVVGTGQPLSVLLGPGVIGKIYDGIQRPLDEIAAKSGAFIGRGIQTTPVDMKKKYHFKPVMKKGDEVGPGFILGTVEETPLLVNKILVPPDHAKGAKLVDIVPEGDYDIEHIIATTEKDGNKAQLKMYHKWPVRKPRPYAERYDPTVPLVTGQRVIDTYFPIAKGGTGAIPGGFGTGKTVTMHQIAKWADSKVVVYIGCGERGNEMTEVLVEFPHLIDPRSGRPLMERTVLVANTSNMPVAAREASIYTGVTMAEYYRDMGYDVVLVADSTSRWAEALREMSGRLEEMPAEEGYPSYLASRLAEFYERAGRVRALGSPDRAGSVTLVGAVSPSGADFTEPVTTHTIRFIKTFWALDTRLAYSRHYPSINWMQSYSGYLEDVAKWWKENVSGDWYELRGESYHILQREDTLKEIVRLLGPEALPDEEKLVLEVARMIKIGILQQNSFDKVDTYCSPEKQVKLVKLMVKFFKEAQKALKAEVPLADIRAMPIIPQLLKAKFDIPEDQLAKLADLDKALDEGFRKLGAGGAKTEEVKVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MW15</accession>
    <name>A0A075MW15_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BNR repeat-like domain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03314</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MW15"/>
    <dbReference type="STRING" id="1459636.NTE_03314"/>
    <dbReference type="KEGG" id="nev:NTE_03314"/>
    <dbReference type="eggNOG" id="arCOG02527">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_926230_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd15482">
        <property type="entry name" value="Sialidase_non-viral"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="Sialidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="300" mass="32084" checksum="4FAC92F2903FD0EF" modified="2014-10-29" version="1">MRRSISAIMLAVVMSLLLANIAGQAIPATDALCFAHGVYNMQAISQGDNLYILWEHDTVANNGQGDHYILFKRSTDNGKTFGETTSLYHSSPLCTAYPHMAVEGSNVYVMWEGGDGNVLFKASNDDGTSFGSTIPLGKGILGSAGTAGYIADGGKVLASGNRAYVVWNDDQFDIILRKSDDGGKRFGDPVNISKNVAESINPRIAISSDDVYVVWLEDMECAFQSEPVCSSKALFAKSDDSGRSFGDPVPLDKLIGSSLSMPRLFSVAADGTMFISCGRKKTTISIFPQVATAARHLAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MW16</accession>
    <name>A0A075MW16_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pyruvate oxidase</fullName>
            <ecNumber evidence="7">1.2.3.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">NTE_01425</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EC" id="1.2.3.3" evidence="7"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700249.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MW16"/>
    <dbReference type="STRING" id="1459636.NTE_01425"/>
    <dbReference type="GeneID" id="41597220"/>
    <dbReference type="KEGG" id="nev:NTE_01425"/>
    <dbReference type="eggNOG" id="arCOG01999">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013748_3_0_2"/>
    <dbReference type="OrthoDB" id="6837at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047112">
        <property type="term" value="F:pyruvate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044272">
        <property type="term" value="P:sulfur compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02014">
        <property type="entry name" value="TPP_POX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07039">
        <property type="entry name" value="TPP_PYR_POX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000007">
        <property type="entry name" value="Acetolactate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047211">
        <property type="entry name" value="POXB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047212">
        <property type="entry name" value="TPP_POXB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047210">
        <property type="entry name" value="TPP_PYR_POXB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42981">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE [UBIQUINONE]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42981:SF2">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE [UBIQUINONE]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="6">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="4">
        <location>
            <begin position="195"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="5">
        <location>
            <begin position="384"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AIF83489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="601" mass="65017" checksum="5D13E2BA3A476E3A" modified="2014-10-29" version="1">MKTADIVAEALMDWGVDVIFGLPGDGINGFIEALRRRASKIRFVLVRHEESAAFMACAYAKYTGKLGACVATSGPGAVHLLTGLYDAKADGAPVIAITGRTYSDMMGSNYQQDVDLLALFSDVSVYNNMINSPEHAEMAVDIACRTALAKKGVSHLTIPIDVQERELRGMYSRHKVAGHTSDALVAYAMPDPKLLEKAAEILNAGRRVVMLVGQGALDATDEVIAVAERLGAPIVKALLGKAVVPDDHPLCTGGIGLLGTSPSSDAMAEADTLLMVGTSFPYIDYLPKPGQARGVQIDLFAEKIGLRYPVEVGLVGDSRLALSALLPLLKEKSHDFARSKQAAMKEWNNLLRERSSRIEMPMKPQFIARIISEELQDNAILSVDSGTNTIWAAQYIDLRKGMKFSLSGTLATMACALPYAIAAQIAYPERQSVAFVGDGGFTMLMGEFATAVKYQLPIKVVIIKNNSLGMIRWEQLAFLGNPEFGVEFAPIDFAKFAEACGAKGYSISDPRDARSLVQEAMSQDGPAIIEALVDPFEPPMPPKVDLDFVSNMAESFARGQPHARRIGLTIFRDQVHEALRKVHSHNDNNNDDGGSSNKTQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MW50</accession>
    <name>A0A075MW50_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">NTE_03452</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701881.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MW50"/>
    <dbReference type="STRING" id="1459636.NTE_03452"/>
    <dbReference type="GeneID" id="41599087"/>
    <dbReference type="KEGG" id="nev:NTE_03452"/>
    <dbReference type="eggNOG" id="arCOG04548">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1507315_0_0_2"/>
    <dbReference type="OrthoDB" id="23833at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050572">
        <property type="entry name" value="Fe-S_Ferredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43687">
        <property type="entry name" value="ADENYLYLSULFATE REDUCTASE, BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43687:SF6">
        <property type="entry name" value="L-ASPARTATE SEMIALDEHYDE SULFURTRANSFERASE IRON-SULFUR SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13187">
        <property type="entry name" value="Fer4_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="9">
        <location>
            <begin position="62"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="9">
        <location>
            <begin position="123"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AIF85480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="166" mass="18443" checksum="342015FEABEB1238" modified="2014-10-29" version="1">MPIDPEFPKNHQVIGKHKHADGQHFHFVWGPGRAAEASENEEVKKSYEARGEQILPLGVHGTAVAVDWDSCISDGACIEACPVQVYQWYRTEQDVPAIEMQNATSEGSGENSLRDGRKDYTDKSDPIREHDCIWCMACVSVCPPQAIKVEESSLKFHEQAASSFKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWA8</accession>
    <name>A0A075MWA8_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative divalent heavy-metal cations transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01506</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWA8"/>
    <dbReference type="STRING" id="1459636.NTE_01506"/>
    <dbReference type="KEGG" id="nev:NTE_01506"/>
    <dbReference type="eggNOG" id="arCOG00576">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015114_6_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="254" mass="26233" checksum="A708EA0E7EC07C48" modified="2014-10-29" version="1">MAENALLQSLLWGFVSSLSLLLGAVTGLTFRLPRKVIASIMAFGSGVLVVALTFSLLGEAFRSSQDILPLMAGFVAGGFAYNFANLLLGKVTGVPRRRRPDGEKKSTDAAAPPGLALLVGSVMDNIPENIALGISIVAAGTANPVLAVAIFLSNYPEALSSVEGMKSDGMSKKFILVSWSVVVAVGTVASAIGFALLAGSNPAVISFFLSFASGAILVMLIESMIPEAFREGGSQIGLATLAGFALAFVVHHFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWD9</accession>
    <name>A0A075MWD9_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWD9"/>
    <dbReference type="KEGG" id="nev:NTE_03420"/>
    <dbReference type="eggNOG" id="arCOG07592">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_468992_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="581" mass="66789" checksum="79E81CC0F6D07716" modified="2014-10-29" version="1">MIPKLNPSSIALLRALKEGLSNLKEIRKAVGVQEWQFNETVKALISQDYIEKKGSVLAFKQNPKTILFRDVSSQYNIEKLLRYSNEQVLVHLVDGPVSAKDIQRSTKLGIATIHRSISDLKSIGAIHKQEEGGDKISIKRDNEDKLYLFARLLKTENERKKIEPYAEVIYRNHSVTIKKVPTGKIADGELTGFSLFSEYGIEYHTAHDYYVKQTSPLTLQDVLLHSIITAAKNSDRNAMSVAMLFYLKNRSRFDPLAIRAAARGYGMSKVWLDVESFIRNGPLRNPSLFPSRKDFEEKARLYDTSSDEYDLPKAYPQLFQEIGDKAPFKISAYLIGGENMRIKGLKDKTKDCDIVTLDTKTFTAVVKVLKEMGYRSINESNLSEDDKRLNAGDILIHSERSSRMDVFNRNIGRNQLYLSERMVKRAKMESFKKLDLGILDDSDIFLLKSIAGRTGDIDDMLKIVNEGQLDWNIVWDEMVKQEDETNANLSGLLLEAIEDLKERKGIEPPFYKKLIRRVLDRNIYWQVRKGKNTLREIVDLLQGADISEKTIRHRIDYLEKKGYLKKLRKRNNEVILEIRNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWF7</accession>
    <name>A0A075MWF7_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02952</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWF7"/>
    <dbReference type="STRING" id="1459636.NTE_02952"/>
    <dbReference type="KEGG" id="nev:NTE_02952"/>
    <dbReference type="HOGENOM" id="CLU_3210585_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="44" mass="5174" checksum="BE4AFC040E6C136E" modified="2014-10-29" version="1">MNNSSWVRKYDYLCEECGMAFASFQEYLEHHKLHHPKSIGTAIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MWJ3</accession>
    <name>A0A075MWJ3_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Universal stress protein UspA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_03470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MWJ3"/>
    <dbReference type="STRING" id="1459636.NTE_03470"/>
    <dbReference type="KEGG" id="nev:NTE_03470"/>
    <dbReference type="eggNOG" id="arCOG02053">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049301_11_1_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00293">
        <property type="entry name" value="USP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46268">
        <property type="entry name" value="STRESS RESPONSE PROTEIN NHAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46268:SF6">
        <property type="entry name" value="UNIVERSAL STRESS PROTEIN UP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UspA" evidence="2">
        <location>
            <begin position="11"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF85498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="163" mass="17941" checksum="44CB22B21583368A" modified="2014-10-29" version="1">MRYMETKKNEIQRILVPIDGSEPAFDAASLAITIARRFDGAQLYLLHVVHIDQILRALGIHSTSESYSKVVDEQVTKARKEADKWFERISKEAEAQEGMKITNIDVKGTSLSIAGEIVDYAEKNNIDLIVIGTRGLGGFTKLLMGSVATGVVNYAPCSVLTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MX40</accession>
    <name>A0A075MX40_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved protein implicated in secretion</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_01788</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF83849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MX40"/>
    <dbReference type="STRING" id="1459636.NTE_01788"/>
    <dbReference type="KEGG" id="nev:NTE_01788"/>
    <dbReference type="eggNOG" id="arCOG00452">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095961_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF83849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="245" mass="26653" checksum="D324B55A9FED10D4" modified="2014-10-29" version="1">MLPRLQHASVQPPFYLIASKTLLGAIIVKMSFGNKWVKPQGESVGHKLIEGIKPQTPLKPRIEEAQKKLQMQIQKLDAINSRINEKDQVIFKRVVLAMQSHDAQHARVLSGELSQIRKMGKMISSAKLALEQIQLRLNTITELGDVVVTLSPAMSVIKGLQGGLSGMMPEADQSFAQISDLLGNIMTDSGQIPSGEIGGYTAVNDDTARIMEEASAIVEMNMKNKFPDLPSTGSSQRSAAEASGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MXZ4</accession>
    <name>A0A075MXZ4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148700781.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MXZ4"/>
    <dbReference type="GeneID" id="41597832"/>
    <dbReference type="KEGG" id="nev:NTE_02099"/>
    <dbReference type="HOGENOM" id="CLU_1187737_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="233" mass="26467" checksum="C5B26E4758C6AC03" modified="2014-10-29" version="1">MITDKQAEMAVSKHKNFGIIAILLTAALVGLTYTYFGDIKSASGFDVYAFDFNILVAVSLGFYFWYLQKQDGDKLQKVANEIREHIEQQRQIQDSIRLNSLNGIKVSLAYTGTTIEHIMKEVVKKQSNTNDLIATAEYLDHLLVIYHSLKPPVDSTLQQLAILRPYIRGEFANKIESVTKHIRYTGLASGDESNDGRPFAVESQGTVMQWLRFAKETIDKIDQLDKEIQDYKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MY05</accession>
    <name>A0A075MY05_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative metal-binding integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_03499</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MY05"/>
    <dbReference type="STRING" id="1459636.NTE_03499"/>
    <dbReference type="KEGG" id="nev:NTE_03499"/>
    <dbReference type="eggNOG" id="arCOG10678">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065506_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018688">
        <property type="entry name" value="PpoB2-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09948">
        <property type="entry name" value="PpoB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF85527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="361" mass="38488" checksum="6CADBFBADC3BAE95" modified="2014-10-29" version="1">MVNKSQKAVIASLIGTSAIAWIASIEQPDMMVAMTTYNPLAISLFTASWTAGMAAMMFPAIAPMVLLYNRFVANSNKEGKEVNQSALIVQEEEGEKPRSSSSIHSLRVILFIGCYLLVWALTGIALLLGWSLVMNNTIMMTTTASAGNNSQLIASIYGVLLIIAGAYQFTPLKRVCIGYCESPLSFFMRRWKDGTSGAVRMGLWHGLYCLGCCWPYFLLMVALGWMNLLWMGLFAGIIFAEKMWSRGIWVARTAGIGLVITGILVISGMLPSLVLSSAASLMSGESGSGGSSDGMVMDNGGIGAMSGVEGTSSMTNDNSSEGSMQMQNPVNNMGNNSEAVVSSPVNSDAMSEMKMPSSASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MY23</accession>
    <name>A0A075MY23_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03529</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MY23"/>
    <dbReference type="KEGG" id="nev:NTE_03529"/>
    <dbReference type="HOGENOM" id="CLU_3394436_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="31" mass="3588" checksum="EEDC7CB9DDE37DF7" modified="2014-10-29" version="1">MMFIRNVLAITMTPKAIKPRVATYIIECFDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MYR4</accession>
    <name>A0A075MYR4_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATPase, type IV secretory pathway VirB11 component like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_02352</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_193354070.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MYR4"/>
    <dbReference type="STRING" id="1459636.NTE_02352"/>
    <dbReference type="GeneID" id="41598068"/>
    <dbReference type="KEGG" id="nev:NTE_02352"/>
    <dbReference type="eggNOG" id="arCOG01817">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005379_2_2_2"/>
    <dbReference type="OrthoDB" id="33500at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01130">
        <property type="entry name" value="VirB11-like_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050921">
        <property type="entry name" value="T4SS_GSP_E_ATPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30486:SF14">
        <property type="entry name" value="FLAGELLA ACCESSORY PROTEIN I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30486">
        <property type="entry name" value="TWITCHING MOTILITY PROTEIN PILT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bacterial type II secretion system protein E" evidence="2">
        <location>
            <begin position="232"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF84404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="559" mass="62174" checksum="4B400958A1ED0654" modified="2014-10-29" version="1">MELAAQASSSSTIIDKKLLELARRVPHLSDYLQKLSGTGIPMPTFYEKLDGGMKNFKVLNLIYPVTDQICIHINSIGTSDGYTEYVIVDPPEPNVLLSSAVDRNFAINSAATEPASEFQQKMVYLEEFLKKICTISKAEVDYGKLDPKAKTLPVYEKDFTSLVYHFIRKRAGLGLLEPFLTDPYLEDISIIGQGNVFVVHKVFGPLKSPVWLTNDDIDGLVIGMSEQFGKTVSHARPVIDATLPEGSRINIVFGKDVSRKGTNATIRRFASVPLSITQIISSKTLDKREAAYMWMMVSEGMSCFINGETASGKTTTMMGITLFIPPTWKVVTIEDTPEITLPHNNWISEVTRDTGSASSSVTMFDLLKAALRQRPNYILVGEIRGVEGNIAFQAMQTGHPVVSTFHAAQMSSLIQRLTGDPIKVPKPNVENLNIALFQAAVQGKEGKPIRRVLSINEIVGYNSGSDSVMFIPIFTWDPSTDSVTFRGRGSSNLFVSKLLLKRGMARKDEGLLYDELELRAAFLERLIQKKIFNYYEVYDHLVKTREIGLEAAYKELGKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MYV6</accession>
    <name>A0A075MYV6_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701015.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MYV6"/>
    <dbReference type="STRING" id="1459636.NTE_02392"/>
    <dbReference type="GeneID" id="41598102"/>
    <dbReference type="KEGG" id="nev:NTE_02392"/>
    <dbReference type="HOGENOM" id="CLU_159725_0_0_2"/>
    <dbReference type="OrthoDB" id="372983at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038723">
        <property type="entry name" value="ArnR1-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14947">
        <property type="entry name" value="HTH_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ArnR1-like winged helix-turn-helix" evidence="1">
        <location>
            <begin position="6"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="86" mass="10120" checksum="97E7AB0542515189" modified="2014-10-29" version="1">MYMKNRSRDEILTEILSGLDEPESRTAIMYKSRLSYAQLQFYHKYLLEKKLIREEDRRWVSTDKGKAFLKASLAASQILNDDNISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MZ57</accession>
    <name>A0A075MZ57_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Excinuclease ABC subunit C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">NTE_02485</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701091.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MZ57"/>
    <dbReference type="STRING" id="1459636.NTE_02485"/>
    <dbReference type="GeneID" id="41598189"/>
    <dbReference type="KEGG" id="nev:NTE_02485"/>
    <dbReference type="eggNOG" id="arCOG04753">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014841_3_2_2"/>
    <dbReference type="OrthoDB" id="121419at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10434">
        <property type="entry name" value="GIY-YIG_UvrC_Cho"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UvrABC system protein C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="entry name" value="GIY-YIG endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.340">
        <property type="entry name" value="UvrC, RNAse H endonuclease domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047296">
        <property type="entry name" value="GIY-YIG_UvrC_Cho"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036876">
        <property type="entry name" value="UVR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050066">
        <property type="entry name" value="UvrABC_protein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004791">
        <property type="entry name" value="UvrC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001162">
        <property type="entry name" value="UvrC_RNase_H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038476">
        <property type="entry name" value="UvrC_RNase_H_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00194">
        <property type="entry name" value="uvrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30562:SF1">
        <property type="entry name" value="UVRABC SYSTEM PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30562">
        <property type="entry name" value="UVRC/OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22920">
        <property type="entry name" value="UvrC_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08459">
        <property type="entry name" value="UvrC_RNaseH_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00465">
        <property type="entry name" value="GIYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46600">
        <property type="entry name" value="C-terminal UvrC-binding domain of UvrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="GIY-YIG endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50165">
        <property type="entry name" value="UVRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0228">DNA excision</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GIY-YIG" evidence="7">
        <location>
            <begin position="15"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="6">
        <location>
            <begin position="205"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="UvrC family homology region profile" evidence="8">
        <location>
            <begin position="297"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AIF84534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="534" mass="60861" checksum="C43596DA69F961EB" modified="2014-10-29" version="1">MMITTAVLREKRIPKNPGVYLMKDTKGQIIYIGKAKDLNKRVTSYFTKHDHDAKTARLVEEIADIEFMVTDNETEAFLLESNLIKRYRPVFNIALKDNSHYSYLKITDEPFPRLLVARRNRNGEFSDPRGRIYGPFVRGSSKYLTVGLLRKLFKVRVCTRLPKVPCLQYFIKNCDAPCIANVTREKYMEGIDALRDILEGKSSVERFAQEMEAEMKRASDVGDYERAKEIRDTLYRLSDLRIRQKMEKANKRPHEEYVGIMRDEKKGVAHVMALKRTHGVISDRRKFEFEMVADNSFSSFLLQYYSSAPAIPQIICTSEEPEEKDVLLMSLEKLAGHTVKIVTAGSSGERRQLVNLIMKNLAMYVERGYAPAVVELKQVLALSVMPETIDCFDVSNLGTDIAVGSSVRFVNGKPYKSGYRKFRIETVPGQNDFAMIAELVRRRYKEPRDLPDLVVIDGGRGQLGAATSALASAGLIISCIGLAKENEEIYVQGQKEPIALPRRNLALRMLQHARDEAHRFGLAYNKSLRRLTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MZ89</accession>
    <name>A0A075MZ89_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Universal stress protein UspA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">NTE_02515</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">SR1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MZ89"/>
    <dbReference type="STRING" id="1459636.NTE_02515"/>
    <dbReference type="KEGG" id="nev:NTE_02515"/>
    <dbReference type="eggNOG" id="arCOG02053">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049301_11_2_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00293">
        <property type="entry name" value="USP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46268">
        <property type="entry name" value="STRESS RESPONSE PROTEIN NHAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46268:SF6">
        <property type="entry name" value="UNIVERSAL STRESS PROTEIN UP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UspA" evidence="2">
        <location>
            <begin position="18"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIF84564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="165" mass="17975" checksum="B9B649B5E3DC3B4A" modified="2014-10-29" version="1">MAMSRKYRRVNCHLVVSRILVPHDGTEMSDRALEKATEFARALKADIIIAHIVDSRFVPPSATLSYISDRTSLEGAKTELVEILKSGAEQMLKEKMAKIKAEGIGVDFILGVGSPADEIVSIARSTESDLIVMGSRQLKSNIIASLGSVARKVLDTAHCPVMIIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MZR7</accession>
    <name>A0A075MZR7_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alkylmercury lyase</fullName>
            <ecNumber evidence="1">4.99.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_02676</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.99.1.2" evidence="1"/>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701239.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MZR7"/>
    <dbReference type="STRING" id="1459636.NTE_02676"/>
    <dbReference type="GeneID" id="41598366"/>
    <dbReference type="KEGG" id="nev:NTE_02676"/>
    <dbReference type="HOGENOM" id="CLU_101685_0_0_2"/>
    <dbReference type="OrthoDB" id="375805at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018836">
        <property type="term" value="F:alkylmercury lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004927">
        <property type="entry name" value="MerB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053717">
        <property type="entry name" value="MerB_lyase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009710">
        <property type="entry name" value="PRK13239.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03243">
        <property type="entry name" value="MerB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01699">
        <property type="entry name" value="ORGNOHGLYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160387">
        <property type="entry name" value="NosL/MerB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF84719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="227" mass="25427" checksum="7CFCD1AA17C77C2F" modified="2014-10-29" version="1">MAKTNQKKMNGNEVQQAIDKIATDIFESLIPEQEQRRIFGQTLQLLANGCPVPPDEIAIRLQVLTDKVISTLRGFGAEFDKDGNVLGVGLTLVPTPHVYKVDGRKLYTWCAADALLFPVMLNHTAYIESPDPVTGEKIRVGVTPDRVVEIEPKSAVVSWVKNVDATNIRGSGCCHVHFFSSPETASRWIEKHPDKMFYPANDVYQAMKHIILNKYGDMTVRQERICC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075MZS0</accession>
    <name>A0A075MZS0_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">NTE_02681</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF84724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075MZS0"/>
    <dbReference type="STRING" id="1459636.NTE_02681"/>
    <dbReference type="KEGG" id="nev:NTE_02681"/>
    <dbReference type="eggNOG" id="arCOG10414">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_643434_0_0_2"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="385"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AIF84724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="459" mass="48703" checksum="1B25D923DCC6900C" modified="2014-10-29" version="1">MRLLSHFYGGTAVSRVPEISASPIKSRNMVGGVKGLGLPFVALLLAAAILPGAYGQSSASSSSSSSSSSSSSSSSSFVVTTNKSVFDSGDRVIVAGTVDLGDNNDNSNKDKAKFVTVKVAKDDVICGQQFVRVERDGSFISRPMKVDCGSGNYTVTAAYRAQLATTGFRIVDEENVVEHSDELAQVRDTVMQATDRVNARIKELVQAGASIPTQAVEKYQLGASEASLAIQSAEYGETSSAHKHMDAALAYFADALDLLSPENTKALLQPQADEDEERRLAAANDRYDRLANIYRTLAGLAEKNGVTDAIFDDIQSLLVEAKRLIGVKDLNSAEPTLALTESMLDKARAKLVEQAASSGNYGDDASVVAATSHENNAAAVNSPEARNLSASADRLEKRAEKLLADAAGNAQAENQIREAISLINVARTAIDDGNYQSARESLSTASKTLIDVNRLIHSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N198</accession>
    <name>A0A075N198_9ARCH</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">NTE_03205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">SR1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701670.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N198"/>
    <dbReference type="STRING" id="1459636.NTE_03205"/>
    <dbReference type="GeneID" id="41598862"/>
    <dbReference type="KEGG" id="nev:NTE_03205"/>
    <dbReference type="eggNOG" id="arCOG10515">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2115372_0_0_2"/>
    <dbReference type="OrthoDB" id="11787at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AIF85234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="114" mass="12648" checksum="D172735A61F158A2" modified="2014-10-29" version="1">MNLGFLPSSSGGGGRSFEAHLAGLQEPAKSIMADLRRFALSLGASVIEEVRPHRVVYAKTLTFRTFLDIEPAVDHLVIEVRTSRQSPPTRIVVKMQEEAEQAKRAIAEAYEKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-10-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A075N1G2</accession>
    <name>A0A075N1G2_9ARCH</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">A-type ATP synthase subunit E</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">atpE</name>
        <name evidence="5" type="ORF">NTE_03280</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candidatus Nitrososphaera evergladensis SR1</name>
        <dbReference type="NCBI Taxonomy" id="1459636"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Nitrososphaerota</taxon>
            <taxon>Nitrososphaeria</taxon>
            <taxon>Nitrososphaerales</taxon>
            <taxon>Nitrososphaeraceae</taxon>
            <taxon>Nitrososphaera</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="PLoS ONE" volume="9" first="E101648" last="E101648">
            <title>Genome Sequence of Candidatus Nitrososphaera evergladensis from Group I.1b Enriched from Everglades Soil Reveals Novel Genomic Features of the Ammonia-Oxidizing Archaea.</title>
            <authorList>
                <person name="Zhalnina K.V."/>
                <person name="Dias R."/>
                <person name="Leonard M.T."/>
                <person name="Dorr de Quadros P."/>
                <person name="Camargo F.A."/>
                <person name="Drew J.C."/>
                <person name="Farmerie W.G."/>
                <person name="Daroub S.H."/>
                <person name="Triplett E.W."/>
            </authorList>
            <dbReference type="PubMed" id="24999826"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">SR1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the A-type ATP synthase that produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Has multiple subunits with at least A(3), B(3), C, D, E, F, H, I and proteolipid K(x).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the V-ATPase E subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP007174">
        <property type="protein sequence ID" value="AIF85309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_148701737.1">
        <property type="nucleotide sequence ID" value="NZ_CP007174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A075N1G2"/>
    <dbReference type="STRING" id="1459636.NTE_03280"/>
    <dbReference type="GeneID" id="41598934"/>
    <dbReference type="KEGG" id="nev:NTE_03280"/>
    <dbReference type="eggNOG" id="arCOG00869">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1335010_0_0_2"/>
    <dbReference type="OrthoDB" id="4691at2157"/>
    <dbReference type="Proteomes" id="UP000028194">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033178">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, catalytic domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2320.30">
        <property type="entry name" value="ATP synthase, E subunit, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.620">
        <property type="entry name" value="F1F0 ATP synthase subunit B, membrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00311">
        <property type="entry name" value="ATP_synth_E_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038495">
        <property type="entry name" value="ATPase_E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002842">
        <property type="entry name" value="ATPase_V1_Esu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45715">
        <property type="entry name" value="ATPASE H+-TRANSPORTING V1 SUBUNIT E1A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01991">
        <property type="entry name" value="vATP-synt_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160527">
        <property type="entry name" value="V-type ATPase subunit E-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AIF85309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000028194"/>
        </source>
    </evidence>
    <sequence length="208" mass="23055" checksum="1C5233BC853653E3" modified="2014-10-29" version="1">MSSNSALERTINKVLSQKETELISQIDSAFQESLKNLEASRGKLDAERARIIESAKKQAENLKRQIVGSSRLSARNKELVMIETDVNEAFERAKAWLASSSKDESYRALLAKVVEEAIPSVGSDDVIVECNKNDTEQVKKIVADLSKKNPKLKARVSDQPINAIGGVRVKSADGTMSFDNTLDSRIERLKPLIRKNIARMLRGEAGEE</sequence>
</entry>
<copyright>
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License
</copyright>
</uniprot>